ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	9.54557342
2	regulation of cilium movement (GO:0003352)	8.04333383
3	primary alcohol catabolic process (GO:0034310)	6.86619386
4	left/right axis specification (GO:0070986)	6.59373812
5	ventricular system development (GO:0021591)	6.51991313
6	intraciliary transport (GO:0042073)	6.37808903
7	vitamin transmembrane transport (GO:0035461)	6.02058342
8	microtubule bundle formation (GO:0001578)	6.01977078
9	cilium organization (GO:0044782)	5.91669169
10	cilium assembly (GO:0042384)	5.74816947
11	centriole assembly (GO:0098534)	5.56802039
12	ethanol metabolic process (GO:0006067)	5.53077848
13	diterpenoid biosynthetic process (GO:0016102)	5.35064629
14	regulation of germinal center formation (GO:0002634)	5.03668906
15	negative regulation of T cell differentiation in thymus (GO:0033085)	4.93594779
16	protein localization to cilium (GO:0061512)	4.93100176
17	tolerance induction (GO:0002507)	4.83416498
18	response to xenobiotic stimulus (GO:0009410)	4.61363127
19	regulation of microtubule-based movement (GO:0060632)	4.50425213
20	cellular component assembly involved in morphogenesis (GO:0010927)	4.43733010
21	cilium morphogenesis (GO:0060271)	4.41155638
22	lung epithelium development (GO:0060428)	4.36231947
23	sperm capacitation (GO:0048240)	4.33731367
24	one-carbon compound transport (GO:0019755)	4.33545056
25	microtubule-based movement (GO:0007018)	4.30220838
26	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.27367057
27	negative regulation of B cell mediated immunity (GO:0002713)	4.18090605
28	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.18090605
29	establishment of apical/basal cell polarity (GO:0035089)	4.14361305
30	nucleoside diphosphate phosphorylation (GO:0006165)	4.12761527
31	cell projection assembly (GO:0030031)	4.05970884
32	ethanol oxidation (GO:0006069)	4.04863027
33	terpenoid biosynthetic process (GO:0016114)	3.90841629
34	hyperosmotic salinity response (GO:0042538)	3.88892362
35	regulation of interleukin-5 production (GO:0032674)	3.85889324
36	microtubule depolymerization (GO:0007019)	3.85672466
37	negative regulation of humoral immune response (GO:0002921)	3.80980801
38	positive regulation of tolerance induction (GO:0002645)	3.74379545
39	glomerular epithelial cell development (GO:0072310)	3.66498965
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.63933225
41	retinoic acid metabolic process (GO:0042573)	3.62214079
42	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.54150122
43	establishment of monopolar cell polarity (GO:0061162)	3.54150122
44	lateral ventricle development (GO:0021670)	3.52439456
45	regulation of interleukin-13 production (GO:0032656)	3.51984444
46	glutathione derivative biosynthetic process (GO:1901687)	3.50365615
47	glutathione derivative metabolic process (GO:1901685)	3.50365615
48	aldehyde catabolic process (GO:0046185)	3.48274336
49	centriole replication (GO:0007099)	3.44837826
50	exogenous drug catabolic process (GO:0042738)	3.34860376
51	microtubule polymerization or depolymerization (GO:0031109)	3.28105418
52	cytoplasmic microtubule organization (GO:0031122)	3.18112661
53	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.16382815
54	hydrogen peroxide catabolic process (GO:0042744)	3.15775747
55	pyrimidine nucleotide catabolic process (GO:0006244)	3.14972007
56	sperm motility (GO:0030317)	3.09391211
57	primary alcohol metabolic process (GO:0034308)	3.04430944
58	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	3.02134617
59	axonemal dynein complex assembly (GO:0070286)	21.6917756
60	drug catabolic process (GO:0042737)	2.99069322
61	epithelial cell differentiation involved in kidney development (GO:0035850)	2.97567180
62	base-excision repair, AP site formation (GO:0006285)	2.96853109
63	retinol metabolic process (GO:0042572)	2.89120599
64	carnitine metabolic process (GO:0009437)	2.82374975
65	negative regulation of inclusion body assembly (GO:0090084)	2.82281849
66	determination of left/right symmetry (GO:0007368)	2.81816958
67	O-glycan processing (GO:0016266)	2.80717005
68	hydrogen peroxide biosynthetic process (GO:0050665)	2.73249481
69	regulation of tolerance induction (GO:0002643)	2.72442390
70	L-ascorbic acid metabolic process (GO:0019852)	2.69796202
71	lateral sprouting from an epithelium (GO:0060601)	2.68603858
72	deoxyribonucleotide catabolic process (GO:0009264)	2.66914972
73	smoothened signaling pathway (GO:0007224)	2.66589026
74	organelle assembly (GO:0070925)	2.66193573
75	determination of bilateral symmetry (GO:0009855)	2.65397366
76	progesterone metabolic process (GO:0042448)	2.61023384
77	establishment of planar polarity (GO:0001736)	2.60878558
78	establishment of tissue polarity (GO:0007164)	2.60878558
79	specification of symmetry (GO:0009799)	2.60147140
80	nonmotile primary cilium assembly (GO:0035058)	2.58197446
81	regulation of collateral sprouting (GO:0048670)	2.57139561
82	glutathione metabolic process (GO:0006749)	2.56429554
83	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.56268816
84	GTP biosynthetic process (GO:0006183)	2.54866154
85	microtubule-based process (GO:0007017)	2.53913916
86	phenol-containing compound catabolic process (GO:0019336)	2.53307686
87	heart looping (GO:0001947)	2.51935187
88	hydrogen peroxide metabolic process (GO:0042743)	2.51831802
89	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.51287463
90	positive regulation of smoothened signaling pathway (GO:0045880)	2.50570948
91	lipoxygenase pathway (GO:0019372)	2.49725917
92	reactive oxygen species biosynthetic process (GO:1903409)	2.48905016
93	multicellular organismal water homeostasis (GO:0050891)	2.41009188
94	deoxyribose phosphate catabolic process (GO:0046386)	2.40927047
95	cilium or flagellum-dependent cell motility (GO:0001539)	17.2529188
96	cilium movement (GO:0003341)	15.7003285
97	motile cilium assembly (GO:0044458)	14.6775035
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.5679915
99	epithelial cilium movement (GO:0003351)	14.2104259
100	axoneme assembly (GO:0035082)	10.1512820

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.77100032
2	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.48426860
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.28270543
4	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	3.23551742
5	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.07884076
6	DROSHA_22980978_ChIP-Seq_HELA_Human	2.94367037
7	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.60671160
8	STAT1_20625510_ChIP-Seq_HELA_Human	2.52573226
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.45972991
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.45525199
11	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.19704038
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.17507812
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.08366812
14	SMC4_20622854_ChIP-Seq_HELA_Human	2.07285122
15	YY1_22570637_ChIP-Seq_MALME-3M_Human	2.05332327
16	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.85273017
17	GATA1_19941826_ChIP-Seq_K562_Human	1.84306912
18	P68_20966046_ChIP-Seq_HELA_Human	1.83785545
19	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.79711862
20	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.72300143
21	TP63_22573176_ChIP-Seq_HFKS_Human	1.69645505
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.69037887
23	PHF8_20622854_ChIP-Seq_HELA_Human	1.64049172
24	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.63973456
25	CTCF_20526341_ChIP-Seq_ESCs_Human	1.63795866
26	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.61658984
27	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.59905022
28	E2F1_20622854_ChIP-Seq_HELA_Human	1.58405756
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54606825
30	P300_27268052_Chip-Seq_Bcells_Human	1.54246886
31	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.50902232
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.50680803
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.50677735
34	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.49956591
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.49194096
36	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.47820317
37	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.46126399
38	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.43670073
39	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.42015398
40	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.38812846
41	* CTCF_27219007_Chip-Seq_Bcells_Human	1.37495695
42	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35619150
43	CEBPB_22108803_ChIP-Seq_LS180_Human	1.35462384
44	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.33238731
45	SMRT_27268052_Chip-Seq_Bcells_Human	1.32313180
46	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.30544493
47	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29878540
48	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.28372681
49	KLF5_25053715_ChIP-Seq_YYC3_Human	1.28059946
50	SOX2_21211035_ChIP-Seq_LN229_Human	1.27712130
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27382512
52	ETV1_20927104_ChIP-Seq_GIST48_Human	1.26778013
53	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.23743296
54	PHF8_20622853_ChIP-Seq_HELA_Human	1.23685409
55	ERG_20517297_ChIP-Seq_VCAP_Human	1.23354860
56	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.22972368
57	RBPJ_21746931_ChIP-Seq_IB4_Human	1.22277052
58	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.20821668
59	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.19675751
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18301755
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18301755
62	TP63_23658742_ChIP-Seq_EP156T_Human	1.18254133
63	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.17796952
64	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16862996
65	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.16645399
66	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.14892476
67	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.14857956
68	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.13597714
69	AR_20517297_ChIP-Seq_VCAP_Human	1.13096971
70	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.12697219
71	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.12045619
72	VDR_22108803_ChIP-Seq_LS180_Human	1.10668893
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09795900
74	CREB1_26743006_Chip-Seq_LNCaP_Human	1.08889562
75	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.08824598
76	SPI1_20517297_ChIP-Seq_HL60_Human	1.07633710
77	AHR_22903824_ChIP-Seq_MCF-7_Human	1.06855624
78	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.06287052
79	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.04168924
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03590060
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03343197
82	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.02913543
83	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01066527
84	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.00805667
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.00296194
86	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.00149574
87	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.99319009
88	ZNF263_19887448_ChIP-Seq_K562_Human	0.97815464
89	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97458352
90	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96571947
91	SOX2_20726797_ChIP-Seq_SW620_Human	0.96511960
92	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.96198630
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94998445
94	GATA2_19941826_ChIP-Seq_K562_Human	0.94997076
95	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94757317
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94688372
97	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.94529576
98	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.94515944
99	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.93578622
100	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.93167791

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	7.24610316
2	MP0008875_abnormal_xenobiotic_pharmacok	6.35582160
3	MP0002132_abnormal_respiratory_system	6.13935464
4	MP0008789_abnormal_olfactory_epithelium	3.80231069
5	MP0001984_abnormal_olfaction	3.76613770
6	MP0004133_heterotaxia	3.32158830
7	MP0002277_abnormal_respiratory_mucosa	3.29465819
8	MP0004043_abnormal_pH_regulation	3.10140072
9	MP0005499_abnormal_olfactory_system	2.60440780
10	MP0005394_taste/olfaction_phenotype	2.60440780
11	MP0002282_abnormal_trachea_morphology	2.53778423
12	MP0003806_abnormal_nucleotide_metabolis	2.50406662
13	MP0005623_abnormal_meninges_morphology	2.47626260
14	MP0000566_synostosis	2.25628862
15	MP0003136_yellow_coat_color	2.12362711
16	MP0004019_abnormal_vitamin_homeostasis	2.09709879
17	MP0005083_abnormal_biliary_tract	2.09313710
18	MP0005377_hearing/vestibular/ear_phenot	1.93491214
19	MP0003878_abnormal_ear_physiology	1.93491214
20	MP0002160_abnormal_reproductive_system	1.76839440
21	MP0001765_abnormal_ion_homeostasis	1.70115273
22	MP0000383_abnormal_hair_follicle	1.67100903
23	MP0009379_abnormal_foot_pigmentation	1.59110132
24	MP0000465_gastrointestinal_hemorrhage	1.58133380
25	MP0002168_other_aberrant_phenotype	1.54669234
26	MP0009780_abnormal_chondrocyte_physiolo	1.48267149
27	MP0002249_abnormal_larynx_morphology	1.45881249
28	MP0010155_abnormal_intestine_physiology	1.40418266
29	MP0009278_abnormal_bone_marrow	1.38543322
30	MP0005395_other_phenotype	1.38048666
31	MP0003656_abnormal_erythrocyte_physiolo	1.37072026
32	MP0005464_abnormal_platelet_physiology	1.31977320
33	MP0005165_increased_susceptibility_to	1.30532079
34	MP0000678_abnormal_parathyroid_gland	1.21147490
35	MP0005636_abnormal_mineral_homeostasis	1.11326968
36	MP0005365_abnormal_bile_salt	1.08071933
37	MP0005085_abnormal_gallbladder_physiolo	1.06166636
38	MP0010030_abnormal_orbit_morphology	1.06065316
39	MP0003718_maternal_effect	1.05253782
40	MP0001849_ear_inflammation	1.02243266
41	MP0010678_abnormal_skin_adnexa	1.01675879
42	MP0002233_abnormal_nose_morphology	0.97208657
43	MP0008995_early_reproductive_senescence	0.96754094
44	MP0001346_abnormal_lacrimal_gland	0.96696028
45	MP0008004_abnormal_stomach_pH	0.96420657
46	MP0009765_abnormal_xenobiotic_induced	0.94285128
47	MP0001293_anophthalmia	0.94279850
48	MP0006036_abnormal_mitochondrial_physio	0.93669452
49	MP0001929_abnormal_gametogenesis	0.93256377
50	MP0002735_abnormal_chemical_nociception	0.91543850
51	MP0002405_respiratory_system_inflammati	0.90525223
52	MP0000681_abnormal_thyroid_gland	0.90101567
53	MP0005397_hematopoietic_system_phenotyp	0.89737018
54	MP0001545_abnormal_hematopoietic_system	0.89737018
55	MP0001485_abnormal_pinna_reflex	0.88371899
56	MP0005220_abnormal_exocrine_pancreas	0.86627058
57	MP0009643_abnormal_urine_homeostasis	0.86229843
58	MP0000490_abnormal_crypts_of	0.85345737
59	MP0005646_abnormal_pituitary_gland	0.81916507
60	MP0002638_abnormal_pupillary_reflex	0.81299266
61	MP0008872_abnormal_physiological_respon	0.79122309
62	MP0008007_abnormal_cellular_replicative	0.77191844
63	MP0003698_abnormal_male_reproductive	0.76592896
64	MP0009763_increased_sensitivity_to	0.76037471
65	MP0005551_abnormal_eye_electrophysiolog	0.75198438
66	MP0002909_abnormal_adrenal_gland	0.73147569
67	MP0002136_abnormal_kidney_physiology	0.72357659
68	MP0002139_abnormal_hepatobiliary_system	0.71647650
69	MP0005389_reproductive_system_phenotype	0.69418497
70	MP0002734_abnormal_mechanical_nocicepti	0.68116250
71	MP0005387_immune_system_phenotype	0.67910956
72	MP0001790_abnormal_immune_system	0.67910956
73	MP0000372_irregular_coat_pigmentation	0.65329855
74	MP0002098_abnormal_vibrissa_morphology	0.63207036
75	MP0002876_abnormal_thyroid_physiology	0.62599205
76	MP0004883_abnormal_blood_vessel	0.59035601
77	MP0001835_abnormal_antigen_presentation	0.58996431
78	MP0003303_peritoneal_inflammation	0.58911296
79	MP0002019_abnormal_tumor_incidence	0.55879644
80	MP0002009_preneoplasia	0.55100945
81	MP0003866_abnormal_defecation	0.54840164
82	MP0008873_increased_physiological_sensi	0.51579246
83	MP0002822_catalepsy	0.49888076
84	MP0001663_abnormal_digestive_system	0.49596782
85	MP0009333_abnormal_splenocyte_physiolog	0.48889572
86	MP0002928_abnormal_bile_duct	0.48880554
87	MP0005376_homeostasis/metabolism_phenot	0.47943077
88	MP0000026_abnormal_inner_ear	0.47877229
89	MP0005409_darkened_coat_color	0.47282559
90	MP0005164_abnormal_response_to	0.46772053
91	MP0001764_abnormal_homeostasis	0.46133748
92	MP0001664_abnormal_digestion	0.45782540
93	MP0001324_abnormal_eye_pigmentation	0.45553388
94	MP0003763_abnormal_thymus_physiology	0.44919150
95	MP0006276_abnormal_autonomic_nervous	0.43314041
96	MP0002135_abnormal_kidney_morphology	0.43043830
97	MP0005195_abnormal_posterior_eye	0.42376796
98	MP0005253_abnormal_eye_physiology	0.42127790
99	MP0003937_abnormal_limbs/digits/tail_de	0.42074150
100	MP0001270_distended_abdomen	0.41722246

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rhinitis (HP:0012384)	9.87750530
2	Chronic bronchitis (HP:0004469)	7.48835988
3	Bronchiectasis (HP:0002110)	7.22136540
4	Nasal polyposis (HP:0100582)	6.52216982
5	Abnormality of the nasal mucosa (HP:0000433)	5.36654327
6	Chronic sinusitis (HP:0011109)	4.73127287
7	Recurrent sinusitis (HP:0011108)	4.46760311
8	Infertility (HP:0000789)	4.31508205
9	Bronchitis (HP:0012387)	4.13227457
10	Recurrent otitis media (HP:0000403)	3.86195417
11	Male infertility (HP:0003251)	3.84323485
12	Pancreatic fibrosis (HP:0100732)	3.69400324
13	True hermaphroditism (HP:0010459)	3.67581578
14	Occipital encephalocele (HP:0002085)	3.60373691
15	Chronic otitis media (HP:0000389)	3.37808319
16	Pancreatic cysts (HP:0001737)	3.15627843
17	Abnormality of midbrain morphology (HP:0002418)	3.12036729
18	Molar tooth sign on MRI (HP:0002419)	3.12036729
19	Cystic liver disease (HP:0006706)	2.99304209
20	Nephronophthisis (HP:0000090)	2.97070048
21	Atelectasis (HP:0100750)	2.80952648
22	Hyperactive renin-angiotensin system (HP:0000841)	2.73003189
23	Tubulointerstitial nephritis (HP:0001970)	2.58023628
24	Postaxial foot polydactyly (HP:0001830)	2.36586486
25	Chronic hepatic failure (HP:0100626)	2.36158852
26	Abnormality of the renal medulla (HP:0100957)	2.25149479
27	Congenital hepatic fibrosis (HP:0002612)	2.21044312
28	Anencephaly (HP:0002323)	2.14411875
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03881971
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	11.9877003
31	Abnormal respiratory epithelium morphology (HP:0012253)	11.2682977
32	Abnormal respiratory motile cilium morphology (HP:0005938)	11.2682977
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.9448754
34	Absent/shortened dynein arms (HP:0200106)	10.9448754
35	Abnormal respiratory motile cilium physiology (HP:0012261)	10.8543889
36	Abnormal ciliary motility (HP:0012262)	10.7599476
37	Medial flaring of the eyebrow (HP:0010747)	1.97223278
38	Male pseudohermaphroditism (HP:0000037)	1.96960696
39	Bell-shaped thorax (HP:0001591)	1.94905287
40	Congenital primary aphakia (HP:0007707)	1.83488246
41	Decreased circulating renin level (HP:0003351)	1.83092893
42	Recurrent bronchitis (HP:0002837)	1.82496591
43	Sclerocornea (HP:0000647)	1.81381789
44	Tubular atrophy (HP:0000092)	1.77953804
45	Gait imbalance (HP:0002141)	1.77562210
46	Oculomotor apraxia (HP:0000657)	1.73040858
47	Renal salt wasting (HP:0000127)	1.68416796
48	Asplenia (HP:0001746)	1.68258886
49	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.67636772
50	Furrowed tongue (HP:0000221)	1.67309957
51	Decreased central vision (HP:0007663)	1.63028656
52	Nephrogenic diabetes insipidus (HP:0009806)	1.62313230
53	Nephropathy (HP:0000112)	1.58101495
54	Postaxial hand polydactyly (HP:0001162)	1.50699504
55	Bile duct proliferation (HP:0001408)	1.48176358
56	Abnormal biliary tract physiology (HP:0012439)	1.48176358
57	Absent frontal sinuses (HP:0002688)	1.47365675
58	Preaxial hand polydactyly (HP:0001177)	1.44148587
59	Dyschromatopsia (HP:0007641)	1.42991028
60	Short nail (HP:0001799)	1.39274728
61	Hyperkalemia (HP:0002153)	1.39231560
62	Abnormality of renin-angiotensin system (HP:0000847)	1.31558413
63	Abnormality of macular pigmentation (HP:0008002)	1.30048244
64	Tubulointerstitial abnormality (HP:0001969)	1.29233541
65	Hypokalemic alkalosis (HP:0001949)	1.28034590
66	Hyperaldosteronism (HP:0000859)	1.27197875
67	Median cleft lip (HP:0000161)	1.26971887
68	Vaginal atresia (HP:0000148)	1.26471648
69	Genital tract atresia (HP:0001827)	1.23610285
70	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.23592876
71	Poor coordination (HP:0002370)	1.22500312
72	Stage 5 chronic kidney disease (HP:0003774)	1.22436750
73	Abnormality of the dental root (HP:0006486)	1.16689736
74	Taurodontia (HP:0000679)	1.16689736
75	Abnormality of permanent molar morphology (HP:0011071)	1.16689736
76	Short thorax (HP:0010306)	1.13480958
77	Abnormal drinking behavior (HP:0030082)	1.12316457
78	Polydipsia (HP:0001959)	1.12316457
79	Central scotoma (HP:0000603)	1.11230116
80	Aplasia of the musculature (HP:0100854)	1.10777206
81	Carpal bone hypoplasia (HP:0001498)	1.10768314
82	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.10046079
83	Abnormality of chloride homeostasis (HP:0011422)	1.09215169
84	Retinitis pigmentosa (HP:0000510)	1.07607994
85	Abnormality of molar morphology (HP:0011070)	1.05087000
86	Abnormality of molar (HP:0011077)	1.05087000
87	Cone-rod dystrophy (HP:0000548)	1.04274424
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.02420007
89	Abnormality of the dental pulp (HP:0006479)	1.00985548
90	Supernumerary spleens (HP:0009799)	1.00870811
91	Abnormality of dentin (HP:0010299)	0.99679126
92	Popliteal pterygium (HP:0009756)	0.99040962
93	Purpura (HP:0000979)	0.95907432
94	Short femoral neck (HP:0100864)	0.93309382
95	Fetal akinesia sequence (HP:0001989)	0.93290413
96	Abnormality of the renal cortex (HP:0011035)	0.92293258
97	Abnormality of monocarboxylic acid metabolism (HP:0010996)	0.91689445
98	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	0.90921397
99	Optic nerve coloboma (HP:0000588)	0.90676834
100	Elevated erythrocyte sedimentation rate (HP:0003565)	0.90636706

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.94188163
2	EPHA2	3.57278336
3	NME1	2.53442834
4	SMG1	2.31881108
5	TLK1	2.16961678
6	STK16	2.16273126
7	VRK2	2.14316384
8	MAPKAPK3	2.05693180
9	MAPK15	11.7257181
10	BCKDK	1.71027861
11	TTK	1.60733730
12	GRK6	1.57743046
13	STK24	1.56235636
14	VRK1	1.39262301
15	TBK1	1.39028394
16	PTK2B	1.38042255
17	CDK19	1.28778779
18	LRRK2	1.28577801
19	CSK	1.16284839
20	NEK6	1.07728741
21	RIPK4	0.94714924
22	MAP3K11	0.94547627
23	PIM2	0.91489585
24	MAP3K3	0.90168248
25	MAP3K2	0.88908204
26	INSRR	0.83964507
27	BTK	0.78872547
28	ZAK	0.76551777
29	AURKA	0.74774036
30	PASK	0.73227621
31	MAP3K7	0.68675570
32	BCR	0.68038486
33	ERN1	0.67373445
34	SYK	0.66832630
35	FES	0.66158841
36	DYRK1B	0.64860091
37	BRSK2	0.63062459
38	PBK	0.62137714
39	PRKCI	0.60805345
40	TRPM7	0.59920942
41	GRK1	0.53792956
42	PNCK	0.53177048
43	CHEK2	0.52792840
44	TEC	0.52684407
45	NUAK1	0.52180055
46	RPS6KB2	0.52035317
47	ATR	0.51071068
48	PRKCQ	0.49284874
49	ZAP70	0.47018302
50	PRKCD	0.46894791
51	CAMKK1	0.44942944
52	CDK9	0.44620430
53	MAP2K4	0.43829105
54	MST1R	0.43457271
55	MAP3K12	0.43068362
56	CDK3	0.42457307
57	MAP2K2	0.40663582
58	OXSR1	0.40361890
59	TSSK6	0.39497832
60	ABL2	0.38853025
61	ERBB2	0.38654850
62	PLK1	0.38390952
63	WNK3	0.37845198
64	MAPK13	0.37417607
65	TAOK3	0.37311698
66	ABL1	0.36817888
67	CAMK2G	0.36007150
68	MAP4K2	0.35689869
69	STK10	0.35378985
70	TESK1	0.34701180
71	ACVR1B	0.34121905
72	PRKDC	0.33888129
73	ADRBK2	0.32766456
74	MARK2	0.31787638
75	ERBB3	0.31510109
76	IRAK1	0.31422718
77	LYN	0.31071643
78	KIT	0.30660976
79	MAP2K7	0.29977501
80	PRKCA	0.28462369
81	MAP3K6	0.26822572
82	PIK3CG	0.26605101
83	EEF2K	0.26568297
84	TAF1	0.26461064
85	MAPK12	0.26447541
86	ITK	0.26375101
87	IRAK2	0.26262824
88	EPHB1	0.26196279
89	ADRBK1	0.25987602
90	MAPK11	0.25015104
91	IGF1R	0.24984032
92	IKBKE	0.24287210
93	PRKACA	0.24160178
94	AKT2	0.23342789
95	HCK	0.21420863
96	IKBKB	0.20870530
97	BMPR1B	0.20685389
98	MAP3K4	0.19860484
99	BLK	0.19285612
100	DYRK1A	0.18352886

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.25628555
2	Chemical carcinogenesis_Homo sapiens_hsa05204	4.32981171
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.09688634
4	Phenylalanine metabolism_Homo sapiens_hsa00360	4.04603320
5	Histidine metabolism_Homo sapiens_hsa00340	3.67035827
6	Tyrosine metabolism_Homo sapiens_hsa00350	3.42672883
7	Huntingtons disease_Homo sapiens_hsa05016	3.28893591
8	Glutathione metabolism_Homo sapiens_hsa00480	3.00804008
9	beta-Alanine metabolism_Homo sapiens_hsa00410	2.64836376
10	Retinol metabolism_Homo sapiens_hsa00830	2.42029300
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.06839545
12	Caffeine metabolism_Homo sapiens_hsa00232	1.88154197
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.83110114
14	Peroxisome_Homo sapiens_hsa04146	1.80269278
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76076045
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.51538865
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49356728
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.47094999
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.43492038
20	Asthma_Homo sapiens_hsa05310	1.39558712
21	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.34383436
22	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.31739127
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23175030
24	Fatty acid degradation_Homo sapiens_hsa00071	1.13769325
25	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.10170637
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.08791183
27	Allograft rejection_Homo sapiens_hsa05330	1.07308372
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.06851993
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.06448594
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.04682647
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01876932
32	Sphingolipid metabolism_Homo sapiens_hsa00600	1.00668141
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97979475
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.96216207
35	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95688046
36	Proteasome_Homo sapiens_hsa03050	0.91197550
37	Graft-versus-host disease_Homo sapiens_hsa05332	0.90658174
38	Nucleotide excision repair_Homo sapiens_hsa03420	0.90045859
39	Base excision repair_Homo sapiens_hsa03410	0.88491626
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.85976554
41	Purine metabolism_Homo sapiens_hsa00230	0.85637796
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.84938071
43	Ribosome_Homo sapiens_hsa03010	0.78249462
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77174179
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74535295
46	Metabolic pathways_Homo sapiens_hsa01100	0.71150559
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.70644530
48	Notch signaling pathway_Homo sapiens_hsa04330	0.70210010
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69441330
50	Parkinsons disease_Homo sapiens_hsa05012	0.69266383
51	ABC transporters_Homo sapiens_hsa02010	0.68494955
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67590685
53	Alzheimers disease_Homo sapiens_hsa05010	0.66377681
54	Taste transduction_Homo sapiens_hsa04742	0.64999768
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.64654107
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64182660
57	RNA polymerase_Homo sapiens_hsa03020	0.63131135
58	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.62810679
59	Tight junction_Homo sapiens_hsa04530	0.62388789
60	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.59972696
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.58303028
62	Olfactory transduction_Homo sapiens_hsa04740	0.57856284
63	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56548168
64	Mismatch repair_Homo sapiens_hsa03430	0.54839881
65	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53513833
66	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53084484
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53018029
68	Salivary secretion_Homo sapiens_hsa04970	0.49236015
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45546823
70	Phototransduction_Homo sapiens_hsa04744	0.43822647
71	Fatty acid elongation_Homo sapiens_hsa00062	0.42977975
72	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.42419531
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42145560
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.41532175
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40750266
76	Pentose phosphate pathway_Homo sapiens_hsa00030	0.39597380
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38118375
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36451067
79	Alcoholism_Homo sapiens_hsa05034	0.35321782
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.35149746
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.34552219
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34146391
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33952823
84	Fanconi anemia pathway_Homo sapiens_hsa03460	0.32081661
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.32013995
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.31925435
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31296350
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.30655911
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.30038946
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.29151016
91	One carbon pool by folate_Homo sapiens_hsa00670	0.27649054
92	Butanoate metabolism_Homo sapiens_hsa00650	0.27307212
93	Serotonergic synapse_Homo sapiens_hsa04726	0.25699231
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25509831
95	Complement and coagulation cascades_Homo sapiens_hsa04610	0.24331253
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.24204011
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.22792309
98	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.22417347
99	Spliceosome_Homo sapiens_hsa03040	0.21854840
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.21055448

C22ORF15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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