ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA replication checkpoint (GO:0000076)	4.83172716
2	meiotic chromosome segregation (GO:0045132)	4.15716308
3	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.13129333
4	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.13129333
5	histone H2A acetylation (GO:0043968)	4.11741872
6	nuclear pore organization (GO:0006999)	3.96259199
7	synapsis (GO:0007129)	3.91851250
8	resolution of meiotic recombination intermediates (GO:0000712)	3.86391911
9	pseudouridine synthesis (GO:0001522)	3.80601720
10	mitotic nuclear envelope disassembly (GO:0007077)	3.61644546
11	nuclear pore complex assembly (GO:0051292)	3.58310112
12	regulation of centriole replication (GO:0046599)	3.57448941
13	DNA topological change (GO:0006265)	3.54033659
14	proteasome assembly (GO:0043248)	3.45586890
15	replication fork processing (GO:0031297)	3.32943074
16	DNA strand renaturation (GO:0000733)	3.30748463
17	mitotic sister chromatid segregation (GO:0000070)	3.28955079
18	amino acid activation (GO:0043038)	3.28133336
19	tRNA aminoacylation (GO:0043039)	3.28133336
20	nuclear envelope disassembly (GO:0051081)	3.27246218
21	membrane disassembly (GO:0030397)	3.27246218
22	DNA strand elongation involved in DNA replication (GO:0006271)	3.25681130
23	maturation of 5.8S rRNA (GO:0000460)	3.22717327
24	tRNA aminoacylation for protein translation (GO:0006418)	3.22702240
25	regulation of translational fidelity (GO:0006450)	3.16434556
26	DNA strand elongation (GO:0022616)	3.15254706
27	nucleobase biosynthetic process (GO:0046112)	3.13952832
28	sister chromatid segregation (GO:0000819)	3.10800943
29	DNA double-strand break processing (GO:0000729)	3.06749060
30	DNA replication initiation (GO:0006270)	3.05786361
31	telomere maintenance via semi-conservative replication (GO:0032201)	3.04749278
32	regulation of centrosome cycle (GO:0046605)	3.02197065
33	attachment of spindle microtubules to kinetochore (GO:0008608)	2.97649383
34	kinetochore organization (GO:0051383)	2.96764414
35	pore complex assembly (GO:0046931)	2.92286915
36	purine nucleobase biosynthetic process (GO:0009113)	2.91877278
37	kinetochore assembly (GO:0051382)	2.90857925
38	double-strand break repair via homologous recombination (GO:0000724)	2.87731747
39	peptidyl-histidine modification (GO:0018202)	2.86842056
40	recombinational repair (GO:0000725)	2.86258529
41	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.84153219
42	mismatch repair (GO:0006298)	2.83597602
43	regulation of centrosome duplication (GO:0010824)	2.83320099
44	mRNA cleavage (GO:0006379)	2.82335944
45	tRNA modification (GO:0006400)	2.80039100
46	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.79287834
47	regulation of translation, ncRNA-mediated (GO:0045974)	2.79287834
48	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.79287834
49	tRNA metabolic process (GO:0006399)	2.77498308
50	biotin metabolic process (GO:0006768)	2.76807186
51	regulation of histone H3-K4 methylation (GO:0051569)	2.74131688
52	DNA catabolic process, exonucleolytic (GO:0000738)	2.73151839
53	mitotic metaphase plate congression (GO:0007080)	2.72741736
54	respiratory chain complex IV assembly (GO:0008535)	2.72011391
55	metaphase plate congression (GO:0051310)	2.71140662
56	telomere maintenance via recombination (GO:0000722)	2.69386597
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.69088026
58	mitochondrial RNA metabolic process (GO:0000959)	2.68813422
59	mitotic recombination (GO:0006312)	2.66946486
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.66368531
61	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.66368531
62	mannosylation (GO:0097502)	2.65701996
63	lactate metabolic process (GO:0006089)	2.65666777
64	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.65320196
65	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.64304759
66	branched-chain amino acid catabolic process (GO:0009083)	2.63622822
67	tRNA processing (GO:0008033)	2.63607284
68	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.62785137
69	aspartate family amino acid biosynthetic process (GO:0009067)	2.62318609
70	non-recombinational repair (GO:0000726)	2.61704570
71	double-strand break repair via nonhomologous end joining (GO:0006303)	2.61704570
72	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.61130336
73	termination of RNA polymerase III transcription (GO:0006386)	2.61130336
74	intra-S DNA damage checkpoint (GO:0031573)	2.59944183
75	folic acid metabolic process (GO:0046655)	2.59333380
76	L-serine metabolic process (GO:0006563)	2.57695493
77	nuclear envelope organization (GO:0006998)	2.57636093
78	ncRNA 3-end processing (GO:0043628)	2.56475093
79	regulation of mitochondrial translation (GO:0070129)	2.56308599
80	DNA recombination (GO:0006310)	2.55290741
81	postreplication repair (GO:0006301)	2.54544370
82	DNA ligation (GO:0006266)	2.52493005
83	methionine biosynthetic process (GO:0009086)	2.50937277
84	telomere maintenance via telomere lengthening (GO:0010833)	2.50912381
85	chromosome segregation (GO:0007059)	2.49885396
86	base-excision repair (GO:0006284)	2.49607530
87	homocysteine metabolic process (GO:0050667)	2.49357031
88	folic acid-containing compound biosynthetic process (GO:0009396)	2.48236063
89	base-excision repair, AP site formation (GO:0006285)	2.47250348
90	regulation of mitotic spindle checkpoint (GO:1903504)	2.46408420
91	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.46408420
92	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.46269487
93	cytochrome complex assembly (GO:0017004)	2.44704989
94	DNA methylation involved in gamete generation (GO:0043046)	2.44693660
95	terpenoid biosynthetic process (GO:0016114)	2.44220767
96	viral mRNA export from host cell nucleus (GO:0046784)	2.42169383
97	centriole replication (GO:0007099)	2.42141060
98	snRNA processing (GO:0016180)	2.41966454
99	positive regulation of megakaryocyte differentiation (GO:0045654)	2.41464700
100	rRNA modification (GO:0000154)	2.41208999

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.69117183
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.42440451
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.58982637
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.52246871
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.51774575
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.46876948
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.25659501
8	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.24112556
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17206959
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.07077772
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.76985870
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.76542984
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.68089179
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53369226
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.47621934
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.42720053
17	* DCP1A_22483619_ChIP-Seq_HELA_Human	2.41071654
18	GABP_19822575_ChIP-Seq_HepG2_Human	2.30326511
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.28913041
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.28755839
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.25439672
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.25261718
23	XRN2_22483619_ChIP-Seq_HELA_Human	2.24967167
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.22237577
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19416829
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.17588497
27	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16357660
28	VDR_23849224_ChIP-Seq_CD4+_Human	2.13938684
29	KDM5A_27292631_Chip-Seq_BREAST_Human	2.10851172
30	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09020628
31	FOXP3_21729870_ChIP-Seq_TREG_Human	2.07427486
32	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.97315072
33	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.96116925
34	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.91330816
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.87939428
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.87559580
37	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.87070159
38	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.86448347
39	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.86267938
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.82297218
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.79707753
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.78889013
43	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.77341407
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73572325
45	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.73235147
46	CIITA_25753668_ChIP-Seq_RAJI_Human	1.67211869
47	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.66079239
48	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.63910109
49	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.61474005
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.59332816
51	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.53747525
52	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.53460341
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.40801826
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.40768902
55	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37669770
56	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.36430056
57	AR_21909140_ChIP-Seq_LNCAP_Human	1.35213727
58	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.31483862
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30942270
60	EWS_26573619_Chip-Seq_HEK293_Human	1.29151915
61	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.28329116
62	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.26288328
63	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.21900751
64	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.18804115
65	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.15939496
66	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.13073136
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09766403
68	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.08422402
69	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.05859202
70	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.04547332
71	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99843950
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.99458085
73	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.98657449
74	* NCOR1_26117541_ChIP-Seq_K562_Human	0.93855133
75	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.93432557
76	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.88984832
77	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.88687433
78	VDR_22108803_ChIP-Seq_LS180_Human	0.88394426
79	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.88260023
80	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.87375899
81	CHD1_26751641_Chip-Seq_LNCaP_Human	0.85003211
82	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.84941797
83	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.82260340
84	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.82197116
85	TFEB_21752829_ChIP-Seq_HELA_Human	0.81232089
86	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.79632491
87	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.77123417
88	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.76784703
89	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.76128878
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.75265591
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.74991912
92	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.72049478
93	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.71643692
94	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.71033777
95	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.70459972
96	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.70050230
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.69470359
98	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.68626254
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.68226986
100	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.66180832

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.83087340
2	MP0008058_abnormal_DNA_repair	3.65995417
3	MP0003111_abnormal_nucleus_morphology	3.53450489
4	MP0003693_abnormal_embryo_hatching	3.08143471
5	MP0003786_premature_aging	2.92141714
6	MP0008995_early_reproductive_senescence	2.57096545
7	MP0004147_increased_porphyrin_level	2.39679831
8	MP0004957_abnormal_blastocyst_morpholog	2.34428936
9	MP0008057_abnormal_DNA_replication	2.27014610
10	MP0008932_abnormal_embryonic_tissue	2.16187024
11	MP0008877_abnormal_DNA_methylation	2.15730687
12	MP0000372_irregular_coat_pigmentation	2.05066640
13	MP0003077_abnormal_cell_cycle	2.04620503
14	MP0008007_abnormal_cellular_replicative	2.03317775
15	MP0006292_abnormal_olfactory_placode	1.99391791
16	MP0001529_abnormal_vocalization	1.95494080
17	MP0003718_maternal_effect	1.87413509
18	MP0002938_white_spotting	1.81101159
19	MP0002234_abnormal_pharynx_morphology	1.79933932
20	MP0005083_abnormal_biliary_tract	1.74158868
21	MP0009697_abnormal_copulation	1.72022327
22	MP0008789_abnormal_olfactory_epithelium	1.61981586
23	MP0002160_abnormal_reproductive_system	1.50121671
24	MP0005367_renal/urinary_system_phenotyp	1.49517761
25	MP0000516_abnormal_urinary_system	1.49517761
26	MP0001764_abnormal_homeostasis	1.27218468
27	MP0003941_abnormal_skin_development	1.24934308
28	MP0002102_abnormal_ear_morphology	1.23988403
29	MP0001929_abnormal_gametogenesis	1.21168510
30	MP0004233_abnormal_muscle_weight	1.20740938
31	MP0003937_abnormal_limbs/digits/tail_de	1.18881742
32	MP0010307_abnormal_tumor_latency	1.18870482
33	MP0006035_abnormal_mitochondrial_morpho	1.18622122
34	MP0005499_abnormal_olfactory_system	1.17140576
35	MP0005394_taste/olfaction_phenotype	1.17140576
36	MP0002210_abnormal_sex_determination	1.16602163
37	MP0000678_abnormal_parathyroid_gland	1.15850292
38	MP0000647_abnormal_sebaceous_gland	1.15039559
39	MP0000358_abnormal_cell_content/	1.13021279
40	MP0000462_abnormal_digestive_system	1.11140839
41	MP0001697_abnormal_embryo_size	1.10935794
42	MP0001661_extended_life_span	1.08461991
43	MP0005075_abnormal_melanosome_morpholog	1.06177888
44	MP0001672_abnormal_embryogenesis/_devel	1.02900781
45	MP0005380_embryogenesis_phenotype	1.02900781
46	MP0008875_abnormal_xenobiotic_pharmacok	1.00876165
47	MP0001145_abnormal_male_reproductive	1.00806395
48	MP0005174_abnormal_tail_pigmentation	1.00023604
49	MP0000350_abnormal_cell_proliferation	0.99515000
50	MP0001293_anophthalmia	0.99301629
51	MP0000653_abnormal_sex_gland	0.98811271
52	MP0010030_abnormal_orbit_morphology	0.97141362
53	MP0005646_abnormal_pituitary_gland	0.96859178
54	MP0000538_abnormal_urinary_bladder	0.96720483
55	MP0002396_abnormal_hematopoietic_system	0.95964506
56	MP0005220_abnormal_exocrine_pancreas	0.95793126
57	MP0008872_abnormal_physiological_respon	0.95686377
58	MP0003136_yellow_coat_color	0.95336169
59	MP0002085_abnormal_embryonic_tissue	0.94802928
60	MP0003755_abnormal_palate_morphology	0.93760326
61	MP0002080_prenatal_lethality	0.93510251
62	MP0003984_embryonic_growth_retardation	0.93184791
63	MP0002233_abnormal_nose_morphology	0.92437321
64	MP0002084_abnormal_developmental_patter	0.91970272
65	MP0004197_abnormal_fetal_growth/weight/	0.91905377
66	MP0004133_heterotaxia	0.91419470
67	MP0005171_absent_coat_pigmentation	0.91284641
68	MP0002088_abnormal_embryonic_growth/wei	0.91216140
69	MP0005332_abnormal_amino_acid	0.90488571
70	MP0003698_abnormal_male_reproductive	0.90380799
71	MP0001984_abnormal_olfaction	0.89707210
72	MP0005645_abnormal_hypothalamus_physiol	0.88900735
73	MP0003942_abnormal_urinary_system	0.87749377
74	MP0003195_calcinosis	0.87125915
75	MP0006036_abnormal_mitochondrial_physio	0.86320326
76	MP0003935_abnormal_craniofacial_develop	0.84552170
77	MP0002132_abnormal_respiratory_system	0.83943304
78	MP0004381_abnormal_hair_follicle	0.83302349
79	MP0000313_abnormal_cell_death	0.82910973
80	MP0000467_abnormal_esophagus_morphology	0.82876712
81	MP0001188_hyperpigmentation	0.82153210
82	MP0003385_abnormal_body_wall	0.81432832
83	MP0000631_abnormal_neuroendocrine_gland	0.81355030
84	MP0002163_abnormal_gland_morphology	0.81272596
85	MP0005389_reproductive_system_phenotype	0.80316367
86	MP0003122_maternal_imprinting	0.80270098
87	MP0005395_other_phenotype	0.80108085
88	MP0001119_abnormal_female_reproductive	0.79232922
89	MP0001730_embryonic_growth_arrest	0.78990729
90	MP0003119_abnormal_digestive_system	0.78290418
91	MP0003121_genomic_imprinting	0.77014660
92	MP0009703_decreased_birth_body	0.76840135
93	MP0001968_abnormal_touch/_nociception	0.75320526
94	MP0010234_abnormal_vibrissa_follicle	0.74470450
95	MP0002751_abnormal_autonomic_nervous	0.72867207
96	MP0002111_abnormal_tail_morphology	0.72373287
97	MP0000427_abnormal_hair_cycle	0.72269899
98	MP0001545_abnormal_hematopoietic_system	0.72116999
99	MP0005397_hematopoietic_system_phenotyp	0.72116999
100	MP0003950_abnormal_plasma_membrane	0.71193485

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.80195647
2	Chromsome breakage (HP:0040012)	3.61947487
3	Abnormal gallbladder physiology (HP:0012438)	3.61621988
4	Cholecystitis (HP:0001082)	3.61621988
5	Hyperthyroidism (HP:0000836)	3.52193431
6	Ependymoma (HP:0002888)	3.38089762
7	Birth length less than 3rd percentile (HP:0003561)	3.28288879
8	Poikiloderma (HP:0001029)	3.25089419
9	Truncus arteriosus (HP:0001660)	3.24170966
10	Type I transferrin isoform profile (HP:0003642)	2.95835777
11	Abnormality of DNA repair (HP:0003254)	2.78543302
12	Abnormality of the preputium (HP:0100587)	2.76270193
13	Squamous cell carcinoma (HP:0002860)	2.75522103
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.68934824
15	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.63790869
16	Abnormal protein N-linked glycosylation (HP:0012347)	2.63790869
17	Abnormal protein glycosylation (HP:0012346)	2.63790869
18	Abnormal glycosylation (HP:0012345)	2.63790869
19	Homocystinuria (HP:0002156)	2.53991562
20	Abnormality of homocysteine metabolism (HP:0010919)	2.53991562
21	Astrocytoma (HP:0009592)	2.52614578
22	Abnormality of the astrocytes (HP:0100707)	2.52614578
23	Meckel diverticulum (HP:0002245)	2.47452601
24	Abnormality of the ileum (HP:0001549)	2.46766270
25	Abnormality of the labia minora (HP:0012880)	2.46076139
26	Small intestinal stenosis (HP:0012848)	2.44770992
27	Duodenal stenosis (HP:0100867)	2.44770992
28	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.43498798
29	Abnormality of chromosome stability (HP:0003220)	2.42557045
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.40956023
31	Acute encephalopathy (HP:0006846)	2.36865579
32	Patellar aplasia (HP:0006443)	2.33067882
33	Absent thumb (HP:0009777)	2.32361486
34	Acute necrotizing encephalopathy (HP:0006965)	2.26602873
35	Popliteal pterygium (HP:0009756)	2.23933488
36	Hypoplasia of the pons (HP:0012110)	2.23920045
37	Cerebellar dysplasia (HP:0007033)	2.21761977
38	Type II lissencephaly (HP:0007260)	2.20455282
39	Duplicated collecting system (HP:0000081)	2.20373521
40	Entropion (HP:0000621)	2.19259914
41	Glioma (HP:0009733)	2.19102280
42	Aplasia/Hypoplasia of the patella (HP:0006498)	2.18938611
43	Ectopic kidney (HP:0000086)	2.18286527
44	Sloping forehead (HP:0000340)	2.15493729
45	Methylmalonic acidemia (HP:0002912)	2.11518263
46	Increased CSF lactate (HP:0002490)	2.09514553
47	Microvesicular hepatic steatosis (HP:0001414)	2.08349699
48	Neoplasm of the adrenal cortex (HP:0100641)	2.07843417
49	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.06990733
50	Hypoplastic pelvis (HP:0008839)	2.06672619
51	Progressive macrocephaly (HP:0004481)	2.03107032
52	Hypertensive crisis (HP:0100735)	2.00881528
53	Abnormality of the duodenum (HP:0002246)	1.98750284
54	Seborrheic dermatitis (HP:0001051)	1.97191844
55	Methylmalonic aciduria (HP:0012120)	1.94693258
56	Abnormality of methionine metabolism (HP:0010901)	1.93931016
57	Abnormality of the pons (HP:0007361)	1.91274663
58	Pancreatic cysts (HP:0001737)	1.90367371
59	Abnormality of the carotid arteries (HP:0005344)	1.89825829
60	Colon cancer (HP:0003003)	1.89203609
61	Septate vagina (HP:0001153)	1.89020980
62	Abnormality of the renal collecting system (HP:0004742)	1.88547160
63	Mitochondrial inheritance (HP:0001427)	1.88290391
64	Abnormality of the parathyroid morphology (HP:0011766)	1.86979150
65	Type 2 muscle fiber atrophy (HP:0003554)	1.86618458
66	Dry hair (HP:0011359)	1.86537049
67	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.86491823
68	Pancreatic fibrosis (HP:0100732)	1.86220325
69	Cerebral edema (HP:0002181)	1.85508447
70	Abnormality of glycolysis (HP:0004366)	1.84841841
71	Hepatocellular necrosis (HP:0001404)	1.82079372
72	Overfolded helix (HP:0000396)	1.81532513
73	Hepatic necrosis (HP:0002605)	1.80820848
74	Absent radius (HP:0003974)	1.77802536
75	Horseshoe kidney (HP:0000085)	1.77211528
76	Cerebral hypomyelination (HP:0006808)	1.76342992
77	Brushfield spots (HP:0001088)	1.75847890
78	Hypoparathyroidism (HP:0000829)	1.75755182
79	Adenoma sebaceum (HP:0009720)	1.75687425
80	Angiofibromas (HP:0010615)	1.75687425
81	Short thumb (HP:0009778)	1.75504870
82	Facial hemangioma (HP:0000329)	1.74019566
83	Abnormally folded helix (HP:0008544)	1.72462896
84	Atelectasis (HP:0100750)	1.70886666
85	Abnormality of placental membranes (HP:0011409)	1.69200845
86	Amniotic constriction ring (HP:0009775)	1.69200845
87	Breast hypoplasia (HP:0003187)	1.67316227
88	Aplasia involving forearm bones (HP:0009822)	1.67180496
89	Absent forearm bone (HP:0003953)	1.67180496
90	Concave nail (HP:0001598)	1.66823475
91	Retinal dysplasia (HP:0007973)	1.66746736
92	Prominent metopic ridge (HP:0005487)	1.65796459
93	Clubbing of toes (HP:0100760)	1.65744946
94	Breech presentation (HP:0001623)	1.65591299
95	Abnormality of cochlea (HP:0000375)	1.64675350
96	Bowel incontinence (HP:0002607)	1.64318595
97	Abnormality of midbrain morphology (HP:0002418)	1.63982569
98	Molar tooth sign on MRI (HP:0002419)	1.63982569
99	Brittle hair (HP:0002299)	1.63963338
100	Abnormality of the metopic suture (HP:0005556)	1.63812660

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.43228210
2	BUB1	3.10118879
3	TRIM28	3.05292757
4	MAP4K2	2.99016597
5	PLK4	2.89496754
6	EIF2AK1	2.85540616
7	VRK2	2.77623993
8	NEK1	2.73492193
9	TTK	2.36089310
10	CDC7	2.34779863
11	BRSK2	2.22330587
12	SRPK1	2.06003103
13	WEE1	1.95338816
14	NUAK1	1.93732416
15	ZAK	1.90949772
16	BCKDK	1.89765227
17	BMPR1B	1.87201331
18	PLK3	1.74948503
19	TSSK6	1.73221221
20	NME1	1.71828149
21	ATR	1.65342736
22	PBK	1.65065785
23	WNK3	1.63882369
24	PLK1	1.52498722
25	NEK2	1.48963030
26	CLK1	1.48922858
27	MUSK	1.48226435
28	CHEK2	1.48021756
29	BRSK1	1.42902582
30	CCNB1	1.39987024
31	MKNK2	1.33269652
32	WNK4	1.28545920
33	CDK8	1.25213089
34	FLT3	1.23091092
35	FGFR2	1.19680197
36	BCR	1.19558727
37	PLK2	1.14812830
38	VRK1	1.12996484
39	PDK2	1.12808309
40	FER	1.12644029
41	ADRBK2	1.12580306
42	EEF2K	1.10253027
43	MAPK13	1.02010976
44	MKNK1	1.01581259
45	PIM2	0.99199087
46	BRD4	0.97934812
47	ATM	0.94367547
48	CHEK1	0.93144950
49	CSNK1G1	0.92976558
50	STK39	0.92665282
51	RAF1	0.88418367
52	AKT3	0.85966938
53	SIK3	0.84386691
54	AURKB	0.83673114
55	TGFBR1	0.83611393
56	MAPKAPK5	0.83346435
57	EIF2AK3	0.81779972
58	STK16	0.81103982
59	CSNK1G3	0.80748556
60	PRKCI	0.80531859
61	CSNK1A1L	0.76122246
62	CAMK1D	0.75902469
63	STK4	0.71907021
64	CDK7	0.71046912
65	LMTK2	0.67048096
66	EIF2AK2	0.64676165
67	TNIK	0.62011650
68	CDK2	0.60739960
69	CDK1	0.60015360
70	GRK1	0.59914466
71	PRKAA1	0.59698324
72	RPS6KB2	0.59148105
73	STK3	0.57764644
74	SMG1	0.56446188
75	MAP3K10	0.55732303
76	PAK3	0.54826019
77	DAPK1	0.53368449
78	MAPKAPK3	0.52805249
79	MST4	0.52424964
80	ERBB3	0.52163677
81	MET	0.51394536
82	OXSR1	0.47285913
83	ICK	0.45983862
84	MAPK11	0.45056942
85	AURKA	0.44408899
86	NTRK3	0.43234180
87	EPHA2	0.42321544
88	CAMK1G	0.41939516
89	PKN2	0.39039708
90	MAP3K4	0.38962413
91	IRAK1	0.38435736
92	NLK	0.37780866
93	CSNK1G2	0.37568652
94	PRKDC	0.37360254
95	MAP3K2	0.34491208
96	CSNK2A1	0.34398276
97	PAK4	0.33535406
98	CSNK1A1	0.32978460
99	MTOR	0.31435071
100	GSK3B	0.29846647

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.33015550
2	Homologous recombination_Homo sapiens_hsa03440	3.19601817
3	Fanconi anemia pathway_Homo sapiens_hsa03460	3.10183791
4	Mismatch repair_Homo sapiens_hsa03430	2.94239740
5	RNA polymerase_Homo sapiens_hsa03020	2.92873267
6	DNA replication_Homo sapiens_hsa03030	2.76496872
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.70897919
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.64957851
9	Base excision repair_Homo sapiens_hsa03410	2.44305954
10	One carbon pool by folate_Homo sapiens_hsa00670	2.33964427
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13619954
12	Proteasome_Homo sapiens_hsa03050	2.11526116
13	RNA transport_Homo sapiens_hsa03013	2.03717724
14	Steroid biosynthesis_Homo sapiens_hsa00100	2.03087387
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.97909666
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.83670969
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.74251876
18	Cell cycle_Homo sapiens_hsa04110	1.73185373
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.72838081
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.72728756
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64542585
22	Basal transcription factors_Homo sapiens_hsa03022	1.59213030
23	Spliceosome_Homo sapiens_hsa03040	1.58495064
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.58186626
25	Propanoate metabolism_Homo sapiens_hsa00640	1.57567103
26	RNA degradation_Homo sapiens_hsa03018	1.57539979
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51817840
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43473245
29	Butanoate metabolism_Homo sapiens_hsa00650	1.43268157
30	Sulfur relay system_Homo sapiens_hsa04122	1.41284970
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.37390877
32	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.34246575
33	Purine metabolism_Homo sapiens_hsa00230	1.26231880
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.23551216
35	Lysine degradation_Homo sapiens_hsa00310	1.23422385
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.23140040
37	Protein export_Homo sapiens_hsa03060	1.21117274
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.14930206
39	Fatty acid elongation_Homo sapiens_hsa00062	1.12407532
40	Carbon metabolism_Homo sapiens_hsa01200	1.03415691
41	Oocyte meiosis_Homo sapiens_hsa04114	0.96795753
42	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96187453
43	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.94562692
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.93314585
45	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.91577749
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89808899
47	Oxidative phosphorylation_Homo sapiens_hsa00190	0.89426632
48	p53 signaling pathway_Homo sapiens_hsa04115	0.88917897
49	Huntingtons disease_Homo sapiens_hsa05016	0.87393432
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87371480
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86252641
52	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.82543353
53	Parkinsons disease_Homo sapiens_hsa05012	0.80924753
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.80499294
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.80214089
56	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.80134373
57	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.78477480
58	Peroxisome_Homo sapiens_hsa04146	0.75216997
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74866650
60	Metabolic pathways_Homo sapiens_hsa01100	0.74715512
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.73695168
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69900794
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69748413
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68763805
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.63068284
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62479348
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61679839
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60535019
69	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.59827519
70	Phototransduction_Homo sapiens_hsa04744	0.59499326
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.57265218
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57072197
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.54064945
74	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.50855960
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.47874807
76	Glutathione metabolism_Homo sapiens_hsa00480	0.47824657
77	Olfactory transduction_Homo sapiens_hsa04740	0.45037778
78	Nicotine addiction_Homo sapiens_hsa05033	0.44681243
79	Arginine biosynthesis_Homo sapiens_hsa00220	0.43781374
80	Sulfur metabolism_Homo sapiens_hsa00920	0.40297899
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37293167
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35263544
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.35001153
84	Regulation of autophagy_Homo sapiens_hsa04140	0.34271944
85	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.32674591
86	Alzheimers disease_Homo sapiens_hsa05010	0.29387175
87	Caffeine metabolism_Homo sapiens_hsa00232	0.28878945
88	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27656619
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.27424302
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26855426
91	MicroRNAs in cancer_Homo sapiens_hsa05206	0.24377654
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22276371
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.21883110
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.21575139
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.21529559
96	mTOR signaling pathway_Homo sapiens_hsa04150	0.21390628
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.18590582
98	Thyroid cancer_Homo sapiens_hsa05216	0.17561680
99	ABC transporters_Homo sapiens_hsa02010	0.17162769
100	Wnt signaling pathway_Homo sapiens_hsa04310	0.16363076

C22ORF29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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