ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.27073759
2	NADH dehydrogenase complex assembly (GO:0010257)	4.27073759
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.27073759
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21996422
5	protein complex biogenesis (GO:0070271)	4.16272717
6	behavioral response to nicotine (GO:0035095)	4.12298630
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.96097332
8	ATP synthesis coupled proton transport (GO:0015986)	3.96097332
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.90169411
10	mitochondrial respiratory chain complex assembly (GO:0033108)	3.86119367
11	respiratory electron transport chain (GO:0022904)	3.74220878
12	electron transport chain (GO:0022900)	3.73419785
13	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.66058471
14	protein neddylation (GO:0045116)	3.64300861
15	neuronal action potential propagation (GO:0019227)	3.51476832
16	ubiquinone biosynthetic process (GO:0006744)	3.33212967
17	protein-cofactor linkage (GO:0018065)	3.24855003
18	regulation of skeletal muscle contraction (GO:0014819)	3.19535095
19	DNA methylation involved in gamete generation (GO:0043046)	3.18371155
20	respiratory chain complex IV assembly (GO:0008535)	3.14603250
21	pyrimidine nucleobase catabolic process (GO:0006208)	3.09940230
22	establishment of mitochondrion localization (GO:0051654)	3.09820980
23	ubiquinone metabolic process (GO:0006743)	3.08325877
24	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.07642924
25	positive regulation of mitochondrial fission (GO:0090141)	3.06868724
26	protein polyglutamylation (GO:0018095)	3.06722925
27	ATP biosynthetic process (GO:0006754)	2.96439155
28	creatine metabolic process (GO:0006600)	2.96029547
29	oxidative phosphorylation (GO:0006119)	2.94822631
30	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.93358580
31	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.93347619
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.93128843
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.93128843
34	nonmotile primary cilium assembly (GO:0035058)	2.92190940
35	metallo-sulfur cluster assembly (GO:0031163)	2.91872417
36	iron-sulfur cluster assembly (GO:0016226)	2.91872417
37	cytochrome complex assembly (GO:0017004)	2.91157412
38	muscle filament sliding (GO:0030049)	2.89827031
39	actin-myosin filament sliding (GO:0033275)	2.89827031
40	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.89349942
41	negative regulation of response to food (GO:0032096)	2.85896832
42	negative regulation of appetite (GO:0032099)	2.85896832
43	regulation of cilium movement (GO:0003352)	2.76627039
44	chaperone-mediated protein transport (GO:0072321)	2.72276417
45	DNA integration (GO:0015074)	2.71163296
46	pyrimidine nucleotide catabolic process (GO:0006244)	2.65591189
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.65090650
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.62663657
49	DNA deamination (GO:0045006)	2.61173873
50	piRNA metabolic process (GO:0034587)	2.60486814
51	gamma-aminobutyric acid transport (GO:0015812)	2.58149562
52	neurotransmitter catabolic process (GO:0042135)	2.58083030
53	succinate metabolic process (GO:0006105)	2.58031980
54	axoneme assembly (GO:0035082)	2.56835943
55	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.55117914
56	mitochondrion transport along microtubule (GO:0047497)	2.55117914
57	DNA replication checkpoint (GO:0000076)	2.54009577
58	hydrogen ion transmembrane transport (GO:1902600)	2.53965421
59	synaptic vesicle maturation (GO:0016188)	2.50971719
60	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.50599917
61	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.48092245
62	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.47674106
63	L-methionine salvage (GO:0071267)	2.47431470
64	L-methionine biosynthetic process (GO:0071265)	2.47431470
65	amino acid salvage (GO:0043102)	2.47431470
66	nucleobase catabolic process (GO:0046113)	2.45244495
67	neuromuscular synaptic transmission (GO:0007274)	2.45223441
68	peptidyl-histidine modification (GO:0018202)	2.44900821
69	resolution of meiotic recombination intermediates (GO:0000712)	2.44161312
70	platelet dense granule organization (GO:0060155)	2.43672893
71	oxygen transport (GO:0015671)	2.40928001
72	response to pheromone (GO:0019236)	2.40318032
73	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.40280935
74	anterograde synaptic vesicle transport (GO:0048490)	2.40249835
75	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.39981416
76	quinone biosynthetic process (GO:1901663)	2.39900798
77	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.39880719
78	negative regulation of telomere maintenance (GO:0032205)	2.39839639
79	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.38217459
80	autophagic vacuole fusion (GO:0000046)	2.36398881
81	short-chain fatty acid metabolic process (GO:0046459)	2.36310191
82	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.36289044
83	regulation of action potential (GO:0098900)	2.35839020
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.35446120
85	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.33439797
86	methionine biosynthetic process (GO:0009086)	2.33420098
87	negative regulation of heart rate (GO:0010459)	2.33077583
88	proton transport (GO:0015992)	2.32365679
89	transmission of nerve impulse (GO:0019226)	2.32252610
90	maturation of SSU-rRNA (GO:0030490)	2.30492424
91	regulation of relaxation of muscle (GO:1901077)	2.30459047
92	aerobic respiration (GO:0009060)	2.29668061
93	dopamine transport (GO:0015872)	2.29663417
94	hydrogen transport (GO:0006818)	2.29587261
95	centriole replication (GO:0007099)	2.27926937
96	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.27381187
97	mannosylation (GO:0097502)	2.26794288
98	2-oxoglutarate metabolic process (GO:0006103)	2.26763366
99	water-soluble vitamin biosynthetic process (GO:0042364)	2.25493501
100	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.25397167

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.02874876
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.41680022
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75594339
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75025833
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.73900926
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.60474147
7	VDR_22108803_ChIP-Seq_LS180_Human	2.52398460
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51335202
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.44250923
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.42683717
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.40262815
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28380623
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10749153
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.02151270
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.98781222
16	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.97073616
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.94484390
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.87009993
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71451208
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68807839
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.68583588
22	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.67891353
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57936295
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57467196
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.56392069
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54675791
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.52930399
28	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.51350589
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51311076
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.50885848
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.50109101
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.48220318
33	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.44733635
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.41776984
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36146144
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.35502198
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32647813
38	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30736657
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29287248
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27248098
41	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26950259
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23089367
43	ERA_21632823_ChIP-Seq_H3396_Human	1.21573096
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20995184
45	EWS_26573619_Chip-Seq_HEK293_Human	1.20790462
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19898377
47	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.19575338
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19460800
49	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.17992517
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.17667507
51	CIITA_25753668_ChIP-Seq_RAJI_Human	1.13212990
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13035333
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11165191
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11055403
55	NCOR_22424771_ChIP-Seq_293T_Human	1.10162366
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.09253137
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.08830645
58	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.08557964
59	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08079185
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07969932
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05654393
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.05386728
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.04279781
64	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04264209
65	FUS_26573619_Chip-Seq_HEK293_Human	1.03947609
66	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.03293543
67	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03275032
68	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02330737
69	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.01496457
70	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.01199074
71	OCT4_20526341_ChIP-Seq_ESCs_Human	1.01029703
72	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00711991
73	MYC_19829295_ChIP-Seq_ESCs_Human	0.98889194
74	KDM5A_27292631_Chip-Seq_BREAST_Human	0.98531422
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96248529
76	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95436061
77	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.93300336
78	DCP1A_22483619_ChIP-Seq_HELA_Human	0.91094851
79	TAF15_26573619_Chip-Seq_HEK293_Human	0.90579491
80	ELK1_19687146_ChIP-ChIP_HELA_Human	0.89950995
81	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89937332
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88922297
83	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.88772808
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88022431
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.87209667
86	NANOG_19829295_ChIP-Seq_ESCs_Human	0.86720360
87	SOX2_19829295_ChIP-Seq_ESCs_Human	0.86720360
88	CBP_20019798_ChIP-Seq_JUKART_Human	0.85744696
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.85744696
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.85379856
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84022201
92	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.83992913
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.83696773
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.83696773
95	* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.83586332
96	* BCL6_27268052_Chip-Seq_Bcells_Human	0.82990190
97	RAC3_21632823_ChIP-Seq_H3396_Human	0.82408207
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.81847755
99	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.81835659
100	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.79906909

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.91369661
2	MP0004145_abnormal_muscle_electrophysio	3.43948458
3	MP0002837_dystrophic_cardiac_calcinosis	2.82851875
4	MP0004147_increased_porphyrin_level	2.63595769
5	MP0003136_yellow_coat_color	2.17747533
6	MP0002653_abnormal_ependyma_morphology	2.12932432
7	MP0001529_abnormal_vocalization	2.12240278
8	MP0006292_abnormal_olfactory_placode	2.11944753
9	MP0006276_abnormal_autonomic_nervous	2.10776331
10	MP0006036_abnormal_mitochondrial_physio	2.10361821
11	MP0004142_abnormal_muscle_tone	2.09911025
12	MP0005646_abnormal_pituitary_gland	2.07937968
13	MP0001968_abnormal_touch/_nociception	2.00913013
14	MP0003787_abnormal_imprinting	1.96508497
15	MP0009046_muscle_twitch	1.95344140
16	MP0002102_abnormal_ear_morphology	1.95046713
17	MP0008877_abnormal_DNA_methylation	1.93371319
18	MP0003122_maternal_imprinting	1.92551470
19	MP0003880_abnormal_central_pattern	1.91359638
20	MP0005645_abnormal_hypothalamus_physiol	1.91109735
21	MP0008995_early_reproductive_senescence	1.86093464
22	MP0001984_abnormal_olfaction	1.75674945
23	MP0006035_abnormal_mitochondrial_morpho	1.73678678
24	MP0004859_abnormal_synaptic_plasticity	1.66951051
25	MP0002272_abnormal_nervous_system	1.63416186
26	MP0004130_abnormal_muscle_cell	1.62070144
27	MP0005423_abnormal_somatic_nervous	1.60019282
28	MP0009745_abnormal_behavioral_response	1.58915374
29	MP0002638_abnormal_pupillary_reflex	1.51330460
30	MP0005551_abnormal_eye_electrophysiolog	1.46718745
31	MP0002736_abnormal_nociception_after	1.45919499
32	MP0000749_muscle_degeneration	1.43889821
33	MP0003635_abnormal_synaptic_transmissio	1.42147945
34	MP0008789_abnormal_olfactory_epithelium	1.40179281
35	MP0002064_seizures	1.37259139
36	MP0001986_abnormal_taste_sensitivity	1.37038863
37	MP0005394_taste/olfaction_phenotype	1.32743910
38	MP0005499_abnormal_olfactory_system	1.32743910
39	MP0003137_abnormal_impulse_conducting	1.27533790
40	MP0001502_abnormal_circadian_rhythm	1.25016589
41	MP0000372_irregular_coat_pigmentation	1.24625357
42	MP0002063_abnormal_learning/memory/cond	1.24176027
43	MP0003011_delayed_dark_adaptation	1.21134076
44	MP0001486_abnormal_startle_reflex	1.20082885
45	MP0003121_genomic_imprinting	1.19425530
46	MP0008058_abnormal_DNA_repair	1.19304808
47	MP0002733_abnormal_thermal_nociception	1.17025586
48	MP0001970_abnormal_pain_threshold	1.15841743
49	MP0002572_abnormal_emotion/affect_behav	1.14910218
50	MP0000631_abnormal_neuroendocrine_gland	1.14897138
51	MP0008872_abnormal_physiological_respon	1.14649471
52	MP0004215_abnormal_myocardial_fiber	1.13145023
53	MP0001188_hyperpigmentation	1.11840816
54	MP0002067_abnormal_sensory_capabilities	1.10962667
55	MP0002106_abnormal_muscle_physiology	1.10020636
56	MP0002234_abnormal_pharynx_morphology	1.09945058
57	MP0005253_abnormal_eye_physiology	1.09045114
58	MP0002557_abnormal_social/conspecific_i	1.07573045
59	MP0005386_behavior/neurological_phenoty	1.07358749
60	MP0004924_abnormal_behavior	1.07358749
61	MP0004036_abnormal_muscle_relaxation	1.04478728
62	MP0008775_abnormal_heart_ventricle	1.02030106
63	MP0004270_analgesia	1.01124628
64	MP0002876_abnormal_thyroid_physiology	0.99216965
65	MP0002160_abnormal_reproductive_system	0.99046712
66	MP0002095_abnormal_skin_pigmentation	0.97158634
67	MP0002735_abnormal_chemical_nociception	0.96793323
68	MP0004043_abnormal_pH_regulation	0.95903961
69	MP0006072_abnormal_retinal_apoptosis	0.94512012
70	MP0002938_white_spotting	0.92813989
71	MP0005083_abnormal_biliary_tract	0.92687899
72	MP0002734_abnormal_mechanical_nocicepti	0.92521270
73	MP0005174_abnormal_tail_pigmentation	0.91709473
74	MP0004885_abnormal_endolymph	0.91496769
75	MP0001764_abnormal_homeostasis	0.91078021
76	MP0005670_abnormal_white_adipose	0.91055980
77	MP0002163_abnormal_gland_morphology	0.90406754
78	MP0001905_abnormal_dopamine_level	0.89189894
79	MP0001485_abnormal_pinna_reflex	0.88684483
80	MP0002269_muscular_atrophy	0.88505646
81	MP0002210_abnormal_sex_determination	0.86680293
82	MP0002822_catalepsy	0.86345670
83	MP0003698_abnormal_male_reproductive	0.86255592
84	MP0005535_abnormal_body_temperature	0.84072040
85	MP0003786_premature_aging	0.83832910
86	MP0005171_absent_coat_pigmentation	0.81602997
87	MP0005369_muscle_phenotype	0.81475649
88	MP0000955_abnormal_spinal_cord	0.79698752
89	MP0001929_abnormal_gametogenesis	0.78889893
90	MP0003879_abnormal_hair_cell	0.78656794
91	MP0005266_abnormal_metabolism	0.78446964
92	MP0001501_abnormal_sleep_pattern	0.77987331
93	MP0002229_neurodegeneration	0.77503535
94	MP0004085_abnormal_heartbeat	0.75472649
95	MP0000778_abnormal_nervous_system	0.75019974
96	MP0000015_abnormal_ear_pigmentation	0.74623334
97	MP0005620_abnormal_muscle_contractility	0.73404863
98	MP0004742_abnormal_vestibular_system	0.73344955
99	MP0002066_abnormal_motor_capabilities/c	0.73108307
100	MP0004484_altered_response_of	0.72743413

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.06392294
2	Abnormal mitochondria in muscle tissue (HP:0008316)	3.93281415
3	Acute encephalopathy (HP:0006846)	3.77400130
4	Mitochondrial inheritance (HP:0001427)	3.68022204
5	Progressive macrocephaly (HP:0004481)	3.40403844
6	Hepatocellular necrosis (HP:0001404)	3.33602624
7	Increased CSF lactate (HP:0002490)	3.23766418
8	Hepatic necrosis (HP:0002605)	3.17666428
9	Hyperthyroidism (HP:0000836)	3.14623867
10	Increased intramyocellular lipid droplets (HP:0012240)	3.04709472
11	Muscle fiber inclusion bodies (HP:0100299)	2.97528381
12	Increased muscle lipid content (HP:0009058)	2.85605288
13	Pancreatic cysts (HP:0001737)	2.84797829
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.79140560
15	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.79140560
16	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.77714535
17	Nemaline bodies (HP:0003798)	2.77251885
18	Lipid accumulation in hepatocytes (HP:0006561)	2.69383859
19	Pancreatic fibrosis (HP:0100732)	2.67578812
20	3-Methylglutaconic aciduria (HP:0003535)	2.67294356
21	Abnormality of midbrain morphology (HP:0002418)	2.58609972
22	Molar tooth sign on MRI (HP:0002419)	2.58609972
23	Truncus arteriosus (HP:0001660)	2.56960303
24	Medial flaring of the eyebrow (HP:0010747)	2.56208988
25	Cerebral edema (HP:0002181)	2.52575237
26	Increased hepatocellular lipid droplets (HP:0006565)	2.47941886
27	Gait imbalance (HP:0002141)	2.47355546
28	Exercise intolerance (HP:0003546)	2.45932006
29	Exercise-induced myalgia (HP:0003738)	2.42125070
30	Lactic acidosis (HP:0003128)	2.40831628
31	True hermaphroditism (HP:0010459)	2.38867190
32	Hyperglycinemia (HP:0002154)	2.36575184
33	Increased serum lactate (HP:0002151)	2.34744209
34	Muscle hypertrophy of the lower extremities (HP:0008968)	2.29965907
35	Myoglobinuria (HP:0002913)	2.27492251
36	Congenital primary aphakia (HP:0007707)	2.24791416
37	Nephrogenic diabetes insipidus (HP:0009806)	2.24785658
38	Optic disc pallor (HP:0000543)	2.24763680
39	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.22339247
40	Abnormality of the labia minora (HP:0012880)	2.21046406
41	Nephronophthisis (HP:0000090)	2.21034438
42	Abnormality of alanine metabolism (HP:0010916)	2.18800618
43	Hyperalaninemia (HP:0003348)	2.18800618
44	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18800618
45	Exercise-induced muscle cramps (HP:0003710)	2.14509463
46	Rimmed vacuoles (HP:0003805)	2.13527481
47	Renal Fanconi syndrome (HP:0001994)	2.11644379
48	Calf muscle hypertrophy (HP:0008981)	2.10222524
49	Focal motor seizures (HP:0011153)	2.10115362
50	Rhabdomyolysis (HP:0003201)	2.09270771
51	Type II lissencephaly (HP:0007260)	2.07896125
52	Respiratory failure (HP:0002878)	2.05215382
53	Polyphagia (HP:0002591)	2.01958432
54	Progressive microcephaly (HP:0000253)	2.01155947
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98551079
56	Abnormality of the renal cortex (HP:0011035)	1.97109070
57	Congenital stationary night blindness (HP:0007642)	1.97053330
58	Abnormal rod and cone electroretinograms (HP:0008323)	1.96998140
59	Type 2 muscle fiber atrophy (HP:0003554)	1.95823232
60	Attenuation of retinal blood vessels (HP:0007843)	1.95694772
61	Cerebral hypomyelination (HP:0006808)	1.92120078
62	Myokymia (HP:0002411)	1.91426503
63	Muscle fiber atrophy (HP:0100295)	1.85044721
64	Reticulocytopenia (HP:0001896)	1.84127058
65	Abnormality of DNA repair (HP:0003254)	1.81457470
66	Abnormality of the renal medulla (HP:0100957)	1.81167409
67	Cerebral palsy (HP:0100021)	1.80604700
68	Broad-based gait (HP:0002136)	1.78592807
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76237593
70	Thyroid-stimulating hormone excess (HP:0002925)	1.75995407
71	Poor coordination (HP:0002370)	1.74793847
72	Lethargy (HP:0001254)	1.72036129
73	Sclerocornea (HP:0000647)	1.71606463
74	Left ventricular hypertrophy (HP:0001712)	1.71344800
75	Anencephaly (HP:0002323)	1.71287835
76	Abnormal number of erythroid precursors (HP:0012131)	1.71083617
77	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.70872105
78	Abnormal drinking behavior (HP:0030082)	1.70506977
79	Polydipsia (HP:0001959)	1.70506977
80	Myopathic facies (HP:0002058)	1.69020469
81	Specific learning disability (HP:0001328)	1.68600489
82	Renal cortical cysts (HP:0000803)	1.67836474
83	Hyperglycinuria (HP:0003108)	1.67756433
84	Aganglionic megacolon (HP:0002251)	1.67669694
85	Lissencephaly (HP:0001339)	1.66946512
86	Pendular nystagmus (HP:0012043)	1.66197076
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.65989690
88	Myotonia (HP:0002486)	1.65406109
89	Retinal dysplasia (HP:0007973)	1.64326914
90	Abnormality of the renal collecting system (HP:0004742)	1.63482004
91	Hyperventilation (HP:0002883)	1.63447432
92	Hypothermia (HP:0002045)	1.63434170
93	Duplicated collecting system (HP:0000081)	1.62847528
94	Abnormality of cells of the erythroid lineage (HP:0012130)	1.61243398
95	Progressive cerebellar ataxia (HP:0002073)	1.60578787
96	Rib fusion (HP:0000902)	1.60467533
97	Cystic liver disease (HP:0006706)	1.60402285
98	Prolonged QT interval (HP:0001657)	1.59754255
99	Hemiparesis (HP:0001269)	1.59194647
100	Emotional lability (HP:0000712)	1.59173340

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	3.67812819
2	MAP4K2	3.05037384
3	BCKDK	3.03078349
4	PINK1	2.97734903
5	MAP3K4	2.77405351
6	PHKG2	2.61995540
7	PHKG1	2.61995540
8	FRK	2.22405217
9	MARK1	2.06934604
10	WNK3	1.97554059
11	MAPK13	1.97163101
12	MAP2K7	1.89375367
13	TLK1	1.81870654
14	DYRK2	1.74825702
15	NME1	1.70737677
16	ADRBK2	1.68248715
17	BMPR1B	1.57592039
18	NUAK1	1.55445891
19	ZAK	1.54689341
20	DAPK2	1.49578184
21	WNK4	1.43980264
22	NTRK3	1.38773893
23	CAMKK2	1.31579895
24	TAOK3	1.31095963
25	RAF1	1.28111977
26	CASK	1.27159988
27	CSNK1G2	1.21514226
28	CDK19	1.19677215
29	MAP2K4	1.19146012
30	CSNK1G3	1.18436088
31	CAMK1	1.17540385
32	DYRK3	1.11861323
33	MAP3K7	1.07481933
34	CCNB1	1.06814895
35	CDC7	1.02494319
36	CSNK1A1L	1.01809753
37	PRKCG	0.95948201
38	ARAF	0.95202556
39	PIK3CA	0.94290217
40	PKN1	0.94289270
41	VRK2	0.92055541
42	PIK3CG	0.90535374
43	GRK1	0.87314433
44	TXK	0.84955967
45	TNK2	0.83969578
46	PAK3	0.83153063
47	MINK1	0.82665992
48	CSNK1G1	0.82545531
49	STK16	0.79578974
50	RIPK4	0.79018084
51	MUSK	0.77361214
52	PRKCQ	0.77241508
53	VRK1	0.76759075
54	MAP3K13	0.75496638
55	NTRK2	0.74008209
56	PLK4	0.73724214
57	PIM2	0.68914279
58	ATR	0.68769126
59	CDK8	0.64235562
60	CAMK4	0.64210416
61	RPS6KA5	0.62503248
62	ADRBK1	0.62314542
63	TRIM28	0.61977624
64	PRKAA1	0.61344815
65	INSRR	0.57829108
66	PRKACA	0.57819056
67	DYRK1B	0.57038516
68	BCR	0.55235541
69	MAP2K6	0.54890183
70	BRAF	0.54324356
71	KSR2	0.53997380
72	MAPK12	0.52852284
73	CAMK2A	0.52577615
74	PDK2	0.51166229
75	STK11	0.48602552
76	PLK2	0.48470148
77	MAP3K11	0.48211815
78	TEC	0.46909306
79	PRKD3	0.45522422
80	DYRK1A	0.43866748
81	ILK	0.43479530
82	OXSR1	0.42236334
83	SGK1	0.42121309
84	SIK2	0.41612518
85	RPS6KA4	0.41055885
86	CSNK1A1	0.40917274
87	ACVR1B	0.40845265
88	PRKG1	0.40483120
89	SYK	0.39676685
90	AURKA	0.39528165
91	MAP2K2	0.39182580
92	EPHA3	0.39115326
93	PLK1	0.39075383
94	SGK494	0.38566884
95	SGK223	0.38566884
96	CDK5	0.38488519
97	GRK7	0.38429231
98	ERBB3	0.37650929
99	UHMK1	0.37413673
100	CAMKK1	0.37088033

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.96021873
2	Parkinsons disease_Homo sapiens_hsa05012	3.66039231
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.79319035
4	Butanoate metabolism_Homo sapiens_hsa00650	2.52413886
5	Huntingtons disease_Homo sapiens_hsa05016	2.48762948
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.47822824
7	RNA polymerase_Homo sapiens_hsa03020	2.38773754
8	Alzheimers disease_Homo sapiens_hsa05010	2.27786876
9	Ribosome_Homo sapiens_hsa03010	2.26778529
10	Homologous recombination_Homo sapiens_hsa03440	2.20619546
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.17792568
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12761007
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.07470608
14	Phototransduction_Homo sapiens_hsa04744	2.04661213
15	Nicotine addiction_Homo sapiens_hsa05033	2.03337132
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.88799534
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.87267951
18	Propanoate metabolism_Homo sapiens_hsa00640	1.85629331
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84308851
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.71973550
21	One carbon pool by folate_Homo sapiens_hsa00670	1.68624251
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65493804
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.55292352
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.50989514
25	Sulfur relay system_Homo sapiens_hsa04122	1.40203284
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.35858578
27	Olfactory transduction_Homo sapiens_hsa04740	1.33386122
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31631519
29	Morphine addiction_Homo sapiens_hsa05032	1.30122817
30	Basal transcription factors_Homo sapiens_hsa03022	1.28366570
31	Regulation of autophagy_Homo sapiens_hsa04140	1.28359582
32	GABAergic synapse_Homo sapiens_hsa04727	1.26652383
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24430542
34	Protein export_Homo sapiens_hsa03060	1.23081517
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20384806
36	RNA degradation_Homo sapiens_hsa03018	1.18639682
37	Purine metabolism_Homo sapiens_hsa00230	1.14122404
38	Peroxisome_Homo sapiens_hsa04146	1.12091397
39	Fatty acid elongation_Homo sapiens_hsa00062	1.11032388
40	Base excision repair_Homo sapiens_hsa03410	1.10092501
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05943602
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.05735215
43	DNA replication_Homo sapiens_hsa03030	1.05497906
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.03180023
45	Mismatch repair_Homo sapiens_hsa03430	1.02907291
46	Circadian entrainment_Homo sapiens_hsa04713	1.01961251
47	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00587636
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.99245785
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98479613
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96559219
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96277618
52	Fatty acid metabolism_Homo sapiens_hsa01212	0.94507893
53	Circadian rhythm_Homo sapiens_hsa04710	0.93544668
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93286208
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91464297
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.90665586
57	Insulin secretion_Homo sapiens_hsa04911	0.89507097
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85873709
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83368214
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.81900648
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.80953371
62	Metabolic pathways_Homo sapiens_hsa01100	0.80464571
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.79013974
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78197448
65	Taste transduction_Homo sapiens_hsa04742	0.75861734
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.69798215
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.65712202
68	Proteasome_Homo sapiens_hsa03050	0.65612928
69	Dopaminergic synapse_Homo sapiens_hsa04728	0.64742718
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.63667915
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61672452
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61212660
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60785423
74	Carbon metabolism_Homo sapiens_hsa01200	0.57968776
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.57410729
76	Amphetamine addiction_Homo sapiens_hsa05031	0.54662292
77	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.53490177
78	Serotonergic synapse_Homo sapiens_hsa04726	0.51609214
79	Spliceosome_Homo sapiens_hsa03040	0.51161734
80	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.50962509
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47526802
82	Fatty acid degradation_Homo sapiens_hsa00071	0.47302685
83	Oocyte meiosis_Homo sapiens_hsa04114	0.43499886
84	Cholinergic synapse_Homo sapiens_hsa04725	0.42703313
85	RNA transport_Homo sapiens_hsa03013	0.42106903
86	Phenylalanine metabolism_Homo sapiens_hsa00360	0.40570606
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40131520
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.38613147
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.36334034
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35921834
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.34208731
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33128336
93	Long-term depression_Homo sapiens_hsa04730	0.33108455
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.28064443
95	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.26383114
96	Salivary secretion_Homo sapiens_hsa04970	0.26079630
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.24928155
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.24337707
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.24301019
100	Alcoholism_Homo sapiens_hsa05034	0.22538328

C22ORF39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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