ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	5.98362314
2	sperm motility (GO:0030317)	5.48884091
3	response to pheromone (GO:0019236)	5.05942484
4	calcium ion-dependent exocytosis (GO:0017156)	4.97378769
5	cellular ketone body metabolic process (GO:0046950)	4.92924523
6	pyrimidine nucleobase catabolic process (GO:0006208)	4.73767212
7	protein polyglutamylation (GO:0018095)	4.63146911
8	protein targeting to Golgi (GO:0000042)	4.40827473
9	fusion of sperm to egg plasma membrane (GO:0007342)	4.37684025
10	ketone body metabolic process (GO:1902224)	4.34378501
11	establishment of protein localization to Golgi (GO:0072600)	4.32149235
12	single strand break repair (GO:0000012)	4.24459741
13	behavioral response to nicotine (GO:0035095)	4.22074743
14	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.21803870
15	nucleobase catabolic process (GO:0046113)	4.18960310
16	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.96596839
17	rRNA catabolic process (GO:0016075)	3.84433476
18	axonemal dynein complex assembly (GO:0070286)	3.80183756
19	microtubule depolymerization (GO:0007019)	3.79880028
20	auditory behavior (GO:0031223)	3.77127611
21	mitochondrion degradation (GO:0000422)	3.66849001
22	protein localization to synapse (GO:0035418)	3.63636650
23	rRNA methylation (GO:0031167)	3.56584862
24	regulation of cilium movement (GO:0003352)	3.53850828
25	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.53013117
26	multicellular organism reproduction (GO:0032504)	3.49083203
27	epithelial cilium movement (GO:0003351)	3.48414711
28	spermatid development (GO:0007286)	3.46743397
29	peptidyl-threonine dephosphorylation (GO:0035970)	3.45060913
30	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.39804706
31	protein localization to Golgi apparatus (GO:0034067)	3.39591387
32	plasma membrane fusion (GO:0045026)	3.37260454
33	positive regulation of mitochondrial fission (GO:0090141)	3.35301603
34	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.30494943
35	calcium ion import (GO:0070509)	3.26012664
36	startle response (GO:0001964)	3.23941065
37	microtubule severing (GO:0051013)	3.23661817
38	sperm-egg recognition (GO:0035036)	3.20850625
39	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.19604078
40	mechanosensory behavior (GO:0007638)	3.18954910
41	regulation of microtubule-based movement (GO:0060632)	3.17941428
42	RNA destabilization (GO:0050779)	3.14432213
43	detection of calcium ion (GO:0005513)	3.09435854
44	spermatid nucleus differentiation (GO:0007289)	3.04867945
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.03920746
46	urinary tract smooth muscle contraction (GO:0014848)	3.02695147
47	regulation of synapse structural plasticity (GO:0051823)	3.02124611
48	growth hormone secretion (GO:0030252)	3.01541539
49	sperm capacitation (GO:0048240)	3.00514133
50	microtubule polymerization or depolymerization (GO:0031109)	3.00023960
51	positive regulation of glycolytic process (GO:0045821)	2.97635884
52	rRNA modification (GO:0000154)	2.94304194
53	short-term memory (GO:0007614)	2.91926043
54	reproduction (GO:0000003)	2.91904239
55	axoneme assembly (GO:0035082)	2.90826208
56	membrane depolarization during action potential (GO:0086010)	2.90674103
57	cilium or flagellum-dependent cell motility (GO:0001539)	2.89339545
58	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.88800919
59	L-fucose metabolic process (GO:0042354)	2.86996416
60	L-fucose catabolic process (GO:0042355)	2.86996416
61	fucose catabolic process (GO:0019317)	2.86996416
62	neuronal action potential (GO:0019228)	2.85919683
63	cilium movement (GO:0003341)	2.84168201
64	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.84134779
65	regulation of glucokinase activity (GO:0033131)	2.83039013
66	regulation of hexokinase activity (GO:1903299)	2.83039013
67	spermatogenesis (GO:0007283)	2.82918917
68	male gamete generation (GO:0048232)	2.82452417
69	dendritic spine morphogenesis (GO:0060997)	2.81832398
70	phosphatidylethanolamine metabolic process (GO:0046337)	2.80073879
71	detection of light stimulus involved in visual perception (GO:0050908)	2.79392803
72	detection of light stimulus involved in sensory perception (GO:0050962)	2.79392803
73	cochlea development (GO:0090102)	2.78859858
74	spinal cord motor neuron differentiation (GO:0021522)	2.76055110
75	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.73275461
76	positive regulation of growth hormone secretion (GO:0060124)	2.73186720
77	synapse assembly (GO:0007416)	2.71733505
78	centriole replication (GO:0007099)	2.71322018
79	regulation of transcription involved in cell fate commitment (GO:0060850)	2.70962236
80	response to auditory stimulus (GO:0010996)	2.66560467
81	coenzyme catabolic process (GO:0009109)	2.65889075
82	nitric oxide mediated signal transduction (GO:0007263)	2.65824753
83	cilium assembly (GO:0042384)	2.64730932
84	cell-cell recognition (GO:0009988)	2.64604900
85	cilium morphogenesis (GO:0060271)	2.63359131
86	insulin secretion (GO:0030073)	2.62627485
87	cilium organization (GO:0044782)	2.61682094
88	chemosensory behavior (GO:0007635)	2.59823506
89	neuromuscular synaptic transmission (GO:0007274)	2.59130153
90	gamete generation (GO:0007276)	2.58457734
91	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.57350590
92	regulation of feeding behavior (GO:0060259)	2.57272249
93	negative regulation of gluconeogenesis (GO:0045721)	2.56868729
94	negative regulation of membrane potential (GO:0045837)	2.55314063
95	regulation of dopamine secretion (GO:0014059)	2.54996917
96	regulation of Rab GTPase activity (GO:0032313)	2.54787486
97	positive regulation of Rab GTPase activity (GO:0032851)	2.54787486
98	binding of sperm to zona pellucida (GO:0007339)	2.54454931
99	regulation of vesicle fusion (GO:0031338)	2.54430220
100	intra-Golgi vesicle-mediated transport (GO:0006891)	2.54320225

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.54746467
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.09668057
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.90589005
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.86838310
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.55343947
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54255267
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35977172
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29322766
9	REST_21632747_ChIP-Seq_MESCs_Mouse	2.25270006
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14772757
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07191410
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02981368
13	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.99126660
14	CBP_20019798_ChIP-Seq_JUKART_Human	1.99126660
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98242198
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90748129
17	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.89460037
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84673083
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.84673083
20	P300_19829295_ChIP-Seq_ESCs_Human	1.82411912
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81915845
22	FUS_26573619_Chip-Seq_HEK293_Human	1.80341976
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.72825569
24	DROSHA_22980978_ChIP-Seq_HELA_Human	1.66718549
25	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.64034383
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.61881985
27	VDR_22108803_ChIP-Seq_LS180_Human	1.57965397
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55808200
29	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.54311131
30	AR_25329375_ChIP-Seq_VCAP_Human	1.53982512
31	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.53005464
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52232259
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51874691
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.48805034
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45059729
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41943147
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.41688098
38	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.41230118
39	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.40781515
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40491675
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37986841
42	STAT3_23295773_ChIP-Seq_U87_Human	1.36381007
43	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.35729691
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34747672
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34341076
46	TCF4_23295773_ChIP-Seq_U87_Human	1.31734476
47	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.30479026
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.28994324
49	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.28451694
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24262891
51	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.23405570
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23198757
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22385756
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21664912
55	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.20014588
56	ERA_21632823_ChIP-Seq_H3396_Human	1.19723260
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18869462
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.17634328
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16428879
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16081804
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.15802241
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14875853
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.14717744
64	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.13880291
65	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.13678358
66	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13565863
67	EWS_26573619_Chip-Seq_HEK293_Human	1.12876574
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12547023
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12214402
70	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11647613
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11521999
72	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10645040
73	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.09408790
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.09133750
75	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.07890184
76	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.07890184
77	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.07200880
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05389840
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03819501
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03578222
81	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03306184
82	TBL1_22424771_ChIP-Seq_293T_Human	1.03065078
83	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02233435
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01407563
85	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00734840
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00185731
87	NCOR_22424771_ChIP-Seq_293T_Human	0.99732432
88	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.97523035
89	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.97348413
90	RAC3_21632823_ChIP-Seq_H3396_Human	0.96793468
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96492718
92	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.96452346
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95984589
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95770408
95	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.95731962
96	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95227712
97	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.94553046
98	* NANOG_20526341_ChIP-Seq_ESCs_Human	0.94543563
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93855975
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93261380

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	4.12701650
2	MP0005410_abnormal_fertilization	3.75994629
3	MP0003122_maternal_imprinting	3.61197413
4	MP0003195_calcinosis	3.49365779
5	MP0003787_abnormal_imprinting	3.38320992
6	MP0008877_abnormal_DNA_methylation	2.69327942
7	MP0004859_abnormal_synaptic_plasticity	2.50579203
8	MP0005423_abnormal_somatic_nervous	2.19461563
9	MP0002928_abnormal_bile_duct	2.17634625
10	MP0005645_abnormal_hypothalamus_physiol	2.17453396
11	MP0003880_abnormal_central_pattern	2.10632958
12	MP0003121_genomic_imprinting	2.07968838
13	MP0009745_abnormal_behavioral_response	2.00997237
14	MP0003123_paternal_imprinting	1.98350325
15	MP0003635_abnormal_synaptic_transmissio	1.92835758
16	MP0002572_abnormal_emotion/affect_behav	1.92484776
17	MP0002735_abnormal_chemical_nociception	1.91381831
18	MP0006276_abnormal_autonomic_nervous	1.90825586
19	MP0005646_abnormal_pituitary_gland	1.90532998
20	MP0002909_abnormal_adrenal_gland	1.88834933
21	MP0003011_delayed_dark_adaptation	1.88688523
22	MP0005377_hearing/vestibular/ear_phenot	1.87445149
23	MP0003878_abnormal_ear_physiology	1.87445149
24	MP0009046_muscle_twitch	1.83137978
25	MP0001529_abnormal_vocalization	1.81827367
26	MP0002272_abnormal_nervous_system	1.81425888
27	MP0002064_seizures	1.78154484
28	MP0005084_abnormal_gallbladder_morpholo	1.75832657
29	MP0010386_abnormal_urinary_bladder	1.75698034
30	MP0001984_abnormal_olfaction	1.75480884
31	MP0002557_abnormal_social/conspecific_i	1.75393005
32	MP0001188_hyperpigmentation	1.69967194
33	MP0003698_abnormal_male_reproductive	1.67412975
34	MP0005379_endocrine/exocrine_gland_phen	1.64280886
35	MP0001968_abnormal_touch/_nociception	1.61917244
36	MP0005551_abnormal_eye_electrophysiolog	1.61273099
37	MP0002837_dystrophic_cardiac_calcinosis	1.59459600
38	MP0002063_abnormal_learning/memory/cond	1.53634391
39	MP0001970_abnormal_pain_threshold	1.53330409
40	MP0003283_abnormal_digestive_organ	1.51011072
41	MP0001486_abnormal_startle_reflex	1.50384271
42	MP0001905_abnormal_dopamine_level	1.48858106
43	MP0003879_abnormal_hair_cell	1.47941388
44	MP0002733_abnormal_thermal_nociception	1.45435204
45	MP0002693_abnormal_pancreas_physiology	1.39800588
46	MP0002102_abnormal_ear_morphology	1.37897835
47	MP0004885_abnormal_endolymph	1.36398304
48	MP0006072_abnormal_retinal_apoptosis	1.35550307
49	MP0004270_analgesia	1.35217848
50	MP0001501_abnormal_sleep_pattern	1.33886081
51	MP0002734_abnormal_mechanical_nocicepti	1.33578044
52	MP0002067_abnormal_sensory_capabilities	1.33404346
53	MP0004133_heterotaxia	1.30725634
54	MP0004742_abnormal_vestibular_system	1.28952484
55	MP0005253_abnormal_eye_physiology	1.26890562
56	MP0001929_abnormal_gametogenesis	1.26684992
57	MP0002163_abnormal_gland_morphology	1.23884289
58	MP0001944_abnormal_pancreas_morphology	1.23664568
59	MP0001440_abnormal_grooming_behavior	1.23368416
60	MP0004142_abnormal_muscle_tone	1.20248298
61	MP0000955_abnormal_spinal_cord	1.16191450
62	MP0002638_abnormal_pupillary_reflex	1.14586110
63	MP0004924_abnormal_behavior	1.13945874
64	MP0005386_behavior/neurological_phenoty	1.13945874
65	MP0002184_abnormal_innervation	1.12466251
66	MP0002876_abnormal_thyroid_physiology	1.12348173
67	MP0003633_abnormal_nervous_system	1.07336997
68	MP0002138_abnormal_hepatobiliary_system	1.04753803
69	MP0002229_neurodegeneration	1.03536494
70	MP0000778_abnormal_nervous_system	1.02541444
71	MP0002653_abnormal_ependyma_morphology	1.02133849
72	MP0002882_abnormal_neuron_morphology	0.99405052
73	MP0004085_abnormal_heartbeat	0.92397733
74	MP0003718_maternal_effect	0.92296900
75	MP0000631_abnormal_neuroendocrine_gland	0.92062434
76	MP0005670_abnormal_white_adipose	0.91489856
77	MP0001485_abnormal_pinna_reflex	0.91231189
78	MP0004811_abnormal_neuron_physiology	0.90753169
79	MP0005535_abnormal_body_temperature	0.90445442
80	MP0006292_abnormal_olfactory_placode	0.88611248
81	MP0003646_muscle_fatigue	0.88557890
82	MP0002069_abnormal_eating/drinking_beha	0.88253772
83	MP0005310_abnormal_salivary_gland	0.85559264
84	MP0002078_abnormal_glucose_homeostasis	0.84758912
85	MP0002161_abnormal_fertility/fecundity	0.84055515
86	MP0002736_abnormal_nociception_after	0.83697861
87	MP0002210_abnormal_sex_determination	0.82057926
88	MP0005085_abnormal_gallbladder_physiolo	0.81183526
89	MP0005332_abnormal_amino_acid	0.81146835
90	MP0002752_abnormal_somatic_nervous	0.78970221
91	MP0002066_abnormal_motor_capabilities/c	0.77439619
92	MP0003631_nervous_system_phenotype	0.76810401
93	MP0005448_abnormal_energy_balance	0.76702813
94	MP0000026_abnormal_inner_ear	0.75790868
95	MP0001765_abnormal_ion_homeostasis	0.74663140
96	MP0005220_abnormal_exocrine_pancreas	0.73952248
97	MP0008961_abnormal_basal_metabolism	0.72550195
98	MP0000678_abnormal_parathyroid_gland	0.70989837
99	MP0001502_abnormal_circadian_rhythm	0.70568216
100	MP0001963_abnormal_hearing_physiology	0.70066100

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ketoacidosis (HP:0001993)	3.77642456
2	Hyperinsulinemic hypoglycemia (HP:0000825)	3.65673054
3	Limb dystonia (HP:0002451)	3.59315629
4	Hypoglycemic seizures (HP:0002173)	3.55581077
5	Chronic hepatic failure (HP:0100626)	3.52855913
6	Myokymia (HP:0002411)	3.49208566
7	Hypoglycemic coma (HP:0001325)	3.48537785
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.46506687
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.43885744
10	Agitation (HP:0000713)	3.42772258
11	Bony spicule pigmentary retinopathy (HP:0007737)	3.33634925
12	Abnormal drinking behavior (HP:0030082)	3.28259633
13	Polydipsia (HP:0001959)	3.28259633
14	Abnormality of midbrain morphology (HP:0002418)	3.22827356
15	Molar tooth sign on MRI (HP:0002419)	3.22827356
16	Ketosis (HP:0001946)	3.11780014
17	Pancreatic fibrosis (HP:0100732)	2.95309440
18	Nephronophthisis (HP:0000090)	2.94985236
19	Polyphagia (HP:0002591)	2.90421916
20	Chronic bronchitis (HP:0004469)	2.82197928
21	Attenuation of retinal blood vessels (HP:0007843)	2.81274069
22	Prominent metopic ridge (HP:0005487)	2.78453187
23	Progressive cerebellar ataxia (HP:0002073)	2.78382720
24	Abnormality of the pancreatic islet cells (HP:0006476)	2.77636178
25	Abnormality of endocrine pancreas physiology (HP:0012093)	2.77636178
26	Hypomagnesemia (HP:0002917)	2.77259465
27	Abnormality of the metopic suture (HP:0005556)	2.75721846
28	Pancreatic cysts (HP:0001737)	2.75483667
29	EEG with generalized epileptiform discharges (HP:0011198)	2.74798508
30	Hypsarrhythmia (HP:0002521)	2.72229603
31	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.71046738
32	Abnormal respiratory motile cilium physiology (HP:0012261)	2.68267642
33	Epileptiform EEG discharges (HP:0011182)	2.68100468
34	Large for gestational age (HP:0001520)	2.64471500
35	True hermaphroditism (HP:0010459)	2.64221113
36	Atonic seizures (HP:0010819)	2.59850693
37	Severe visual impairment (HP:0001141)	2.57732666
38	Hypothermia (HP:0002045)	2.55206526
39	Late onset (HP:0003584)	2.54695481
40	Dialeptic seizures (HP:0011146)	2.52764447
41	Polyuria (HP:0000103)	2.49372456
42	Increased circulating renin level (HP:0000848)	2.48561833
43	Gait imbalance (HP:0002141)	2.48263441
44	Febrile seizures (HP:0002373)	2.39682308
45	Poor suck (HP:0002033)	2.38341601
46	Abnormality of the renal medulla (HP:0100957)	2.37123478
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.34014733
48	Medial flaring of the eyebrow (HP:0010747)	2.33734721
49	Decreased circulating renin level (HP:0003351)	2.30689801
50	Abnormal urine output (HP:0012590)	2.29258558
51	Insulin-resistant diabetes mellitus (HP:0000831)	2.27065849
52	Absence seizures (HP:0002121)	2.26055027
53	Failure to thrive in infancy (HP:0001531)	2.23809962
54	Methylmalonic acidemia (HP:0002912)	2.21589334
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21262963
56	Absent/shortened dynein arms (HP:0200106)	2.21262963
57	Drooling (HP:0002307)	2.20046190
58	Epileptic encephalopathy (HP:0200134)	2.19434601
59	Focal seizures (HP:0007359)	2.18637508
60	Tetany (HP:0001281)	2.17156044
61	Decreased central vision (HP:0007663)	2.16283127
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13389476
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.13389476
64	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.12503561
65	Abnormality of renin-angiotensin system (HP:0000847)	2.11945563
66	Hyperkalemia (HP:0002153)	2.11752099
67	Rhinitis (HP:0012384)	2.10062944
68	Congenital stationary night blindness (HP:0007642)	2.09434268
69	Type II lissencephaly (HP:0007260)	2.08650756
70	Abnormality of magnesium homeostasis (HP:0004921)	2.08601426
71	Hyperventilation (HP:0002883)	2.08351379
72	Glycosuria (HP:0003076)	2.07801134
73	Abnormality of urine glucose concentration (HP:0011016)	2.07801134
74	Renal Fanconi syndrome (HP:0001994)	2.07799122
75	Pendular nystagmus (HP:0012043)	2.06504285
76	Tubulointerstitial nephritis (HP:0001970)	2.05674494
77	Generalized aminoaciduria (HP:0002909)	2.05654421
78	Hepatoblastoma (HP:0002884)	2.05398696
79	Congenital primary aphakia (HP:0007707)	2.02530380
80	Abnormality of renal excretion (HP:0011036)	2.01533055
81	Abnormality of the renal cortex (HP:0011035)	2.00988762
82	Hypokalemia (HP:0002900)	2.00498791
83	Abnormality of macular pigmentation (HP:0008002)	1.99204234
84	Excessive salivation (HP:0003781)	1.98879993
85	Abnormal pancreas size (HP:0012094)	1.98450623
86	Inability to walk (HP:0002540)	1.98355462
87	Tachypnea (HP:0002789)	1.98073096
88	Abnormal ciliary motility (HP:0012262)	1.96929349
89	Occipital encephalocele (HP:0002085)	1.96020083
90	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.95623152
91	Cystic liver disease (HP:0006706)	1.94669001
92	Amblyopia (HP:0000646)	1.94095176
93	Menstrual irregularities (HP:0000858)	1.93193261
94	Hyperphosphaturia (HP:0003109)	1.92205285
95	Abnormality of potassium homeostasis (HP:0011042)	1.91599883
96	Symptomatic seizures (HP:0011145)	1.90821550
97	Retinal dysplasia (HP:0007973)	1.90308585
98	Hyperglycinemia (HP:0002154)	1.88218406
99	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.87954060
100	Abnormality of the labia minora (HP:0012880)	1.85341770

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.16691729
2	MARK1	3.64789932
3	CASK	3.31735632
4	PINK1	2.87805960
5	MAP3K9	2.68521602
6	TNIK	2.58958604
7	TESK1	2.55812032
8	MAP3K4	2.38801161
9	DYRK2	2.36228025
10	BLK	2.34206589
11	CAMKK2	2.24905895
12	MAP4K2	2.24539206
13	DDR2	2.23556530
14	CAMK1G	2.16026577
15	CAMK1D	2.13358159
16	PLK4	2.07765235
17	INSRR	1.91857734
18	WNK3	1.88149589
19	MAP2K7	1.86191588
20	NTRK3	1.82506351
21	MAPK13	1.49208757
22	PLK2	1.39573785
23	ADRBK2	1.39327218
24	DAPK2	1.37600733
25	TYRO3	1.35622306
26	PRKCG	1.34942423
27	PHKG2	1.33461507
28	PHKG1	1.33461507
29	CSNK1G2	1.29366960
30	DYRK3	1.22944004
31	PAK3	1.22121966
32	CSNK1G3	1.20065188
33	UHMK1	1.10904173
34	MINK1	1.08512572
35	PNCK	1.08487610
36	BCR	1.08357768
37	GRK1	1.08228883
38	STK38L	1.04686374
39	STK38	1.04650688
40	TRIM28	0.99810642
41	MAPK15	0.97944114
42	WNK4	0.95666730
43	CSNK1G1	0.93919580
44	CSNK1A1L	0.90846047
45	PDK1	0.90701450
46	NTRK2	0.89790480
47	SGK223	0.89011766
48	SGK494	0.89011766
49	PASK	0.87803345
50	SIK2	0.87397792
51	CAMK4	0.84734527
52	OXSR1	0.84569100
53	PRKCE	0.84355208
54	GRK7	0.81812866
55	MAP2K4	0.79572994
56	CAMK2A	0.78106179
57	PRKCZ	0.77948676
58	PRKG1	0.77271549
59	SGK2	0.74868769
60	CDK5	0.73608770
61	ERBB3	0.73378232
62	PRKCH	0.71704720
63	SGK1	0.70682413
64	TLK1	0.70596542
65	CAMK1	0.68488038
66	CDK19	0.68244681
67	PDPK1	0.68224272
68	PTK2B	0.66290652
69	FGFR2	0.66205677
70	CSNK1E	0.65432587
71	DYRK1A	0.64908868
72	DYRK1B	0.64506884
73	MARK2	0.63653273
74	ACVR1B	0.62824023
75	PRKAA1	0.59155622
76	BMPR1B	0.58636640
77	PKN1	0.57082485
78	MAP3K2	0.56845670
79	SGK3	0.56295124
80	CAMKK1	0.56232587
81	ADRBK1	0.51388421
82	BCKDK	0.51203749
83	PRKACA	0.49854040
84	STK16	0.48154047
85	ZAK	0.47855841
86	RPS6KA2	0.47482033
87	PRKACB	0.43464384
88	CSNK1A1	0.41857958
89	HIPK2	0.41194538
90	WNK1	0.40172181
91	CAMK2D	0.37624681
92	PRKCI	0.36857394
93	PRKAA2	0.31355265
94	RPS6KA3	0.31086774
95	CAMK2B	0.30862643
96	GSK3B	0.30255239
97	PRKCB	0.29684457
98	PRKCA	0.29260408
99	CSNK1D	0.27256595
100	BRD4	0.25968707

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.19781159
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.05952289
3	Nicotine addiction_Homo sapiens_hsa05033	2.98519880
4	Butanoate metabolism_Homo sapiens_hsa00650	2.83851913
5	Regulation of autophagy_Homo sapiens_hsa04140	2.62270044
6	Insulin secretion_Homo sapiens_hsa04911	2.54646415
7	Taste transduction_Homo sapiens_hsa04742	2.20664646
8	Type II diabetes mellitus_Homo sapiens_hsa04930	2.12765343
9	GABAergic synapse_Homo sapiens_hsa04727	1.97249341
10	Phototransduction_Homo sapiens_hsa04744	1.95263702
11	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.84438294
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.81043911
13	Morphine addiction_Homo sapiens_hsa05032	1.80818775
14	Protein export_Homo sapiens_hsa03060	1.78802458
15	Serotonergic synapse_Homo sapiens_hsa04726	1.73201245
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.71309582
17	Olfactory transduction_Homo sapiens_hsa04740	1.68672801
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63544261
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57817086
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.57471457
21	Cocaine addiction_Homo sapiens_hsa05030	1.56821861
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.56368715
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48372735
24	Circadian entrainment_Homo sapiens_hsa04713	1.47553494
25	Dopaminergic synapse_Homo sapiens_hsa04728	1.45375114
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42724620
27	Propanoate metabolism_Homo sapiens_hsa00640	1.40226558
28	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.38556224
29	Caffeine metabolism_Homo sapiens_hsa00232	1.33075865
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.32630450
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.32392672
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31948544
33	Fatty acid degradation_Homo sapiens_hsa00071	1.31905906
34	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.31620627
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23361066
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.23075474
37	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.16828322
38	Amphetamine addiction_Homo sapiens_hsa05031	1.16603645
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.14835134
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11797628
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08706804
42	Cholinergic synapse_Homo sapiens_hsa04725	1.03501442
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.01565790
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99840171
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99379372
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.98032470
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96001382
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.88914574
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.87433246
50	Parkinsons disease_Homo sapiens_hsa05012	0.86977027
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.85774127
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.83669160
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.80536146
54	Renin secretion_Homo sapiens_hsa04924	0.80305153
55	Long-term depression_Homo sapiens_hsa04730	0.76650903
56	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76561714
57	Salivary secretion_Homo sapiens_hsa04970	0.76513569
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69593949
59	ABC transporters_Homo sapiens_hsa02010	0.67537736
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.67120216
61	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.65463252
62	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.65177386
63	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64962511
64	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.60267538
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.59935607
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.57950479
67	Gastric acid secretion_Homo sapiens_hsa04971	0.57329992
68	Huntingtons disease_Homo sapiens_hsa05016	0.57020645
69	Peroxisome_Homo sapiens_hsa04146	0.55409727
70	Alzheimers disease_Homo sapiens_hsa05010	0.54969682
71	Axon guidance_Homo sapiens_hsa04360	0.54555121
72	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53307389
73	Basal transcription factors_Homo sapiens_hsa03022	0.50449332
74	Bile secretion_Homo sapiens_hsa04976	0.49684153
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.47175731
76	PPAR signaling pathway_Homo sapiens_hsa03320	0.46738913
77	Gap junction_Homo sapiens_hsa04540	0.46265884
78	Circadian rhythm_Homo sapiens_hsa04710	0.45739854
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.44015244
80	Mineral absorption_Homo sapiens_hsa04978	0.43433038
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41308398
82	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41297051
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40713441
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.38916887
85	Pancreatic secretion_Homo sapiens_hsa04972	0.38538344
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37945820
87	Retinol metabolism_Homo sapiens_hsa00830	0.37926336
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37309756
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35860092
90	Metabolic pathways_Homo sapiens_hsa01100	0.34994209
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33984663
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33755420
93	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.33040179
94	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32898250
95	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.32525617
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.30700845
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30531617
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.28886873
99	Nitrogen metabolism_Homo sapiens_hsa00910	0.28683543
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27211814

C22ORF42

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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