C2CD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid metabolic process (GO:0008211)7.88932340
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.17689160
3L-phenylalanine catabolic process (GO:0006559)7.17689160
4low-density lipoprotein particle clearance (GO:0034383)7.11603285
5L-phenylalanine metabolic process (GO:0006558)6.81871275
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.81871275
7androgen biosynthetic process (GO:0006702)6.62894696
8aromatic amino acid family catabolic process (GO:0009074)6.51131931
9C21-steroid hormone biosynthetic process (GO:0006700)6.41795890
10cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.02277275
11indole-containing compound catabolic process (GO:0042436)5.94201742
12indolalkylamine catabolic process (GO:0046218)5.94201742
13tryptophan catabolic process (GO:0006569)5.94201742
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82664654
15kynurenine metabolic process (GO:0070189)5.78167637
16bile acid biosynthetic process (GO:0006699)5.74428493
17tryptophan metabolic process (GO:0006568)5.62446782
18alpha-linolenic acid metabolic process (GO:0036109)5.46954133
19glyoxylate metabolic process (GO:0046487)5.44835006
20urea metabolic process (GO:0019627)5.29996236
21urea cycle (GO:0000050)5.29996236
22high-density lipoprotein particle remodeling (GO:0034375)5.24033033
23complement activation, alternative pathway (GO:0006957)5.22721616
24negative regulation of fibrinolysis (GO:0051918)5.21098484
25peptidyl-glutamic acid carboxylation (GO:0017187)5.15607578
26protein carboxylation (GO:0018214)5.15607578
27cysteine metabolic process (GO:0006534)5.14621979
28regulation of protein activation cascade (GO:2000257)5.14261801
29sulfur amino acid catabolic process (GO:0000098)5.07860786
30regulation of fibrinolysis (GO:0051917)5.04617722
31cellular response to antibiotic (GO:0071236)5.02382543
32progesterone metabolic process (GO:0042448)5.00732423
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93815900
34response to follicle-stimulating hormone (GO:0032354)4.90490180
35bile acid metabolic process (GO:0008206)4.87565047
36nitrogen cycle metabolic process (GO:0071941)4.87172910
37cellular response to epinephrine stimulus (GO:0071872)4.85740251
38serine family amino acid catabolic process (GO:0009071)4.83392862
39regulation of complement activation (GO:0030449)4.83245499
40homocysteine metabolic process (GO:0050667)4.74488128
41estrogen biosynthetic process (GO:0006703)4.74184737
42C21-steroid hormone metabolic process (GO:0008207)4.73360174
43aromatic amino acid family metabolic process (GO:0009072)4.69743733
44regulation of triglyceride catabolic process (GO:0010896)4.66645759
45tyrosine metabolic process (GO:0006570)4.57104764
46cellular response to growth hormone stimulus (GO:0071378)4.57059454
47reverse cholesterol transport (GO:0043691)4.55186712
48lysine metabolic process (GO:0006553)4.53308322
49lysine catabolic process (GO:0006554)4.53308322
50amino-acid betaine metabolic process (GO:0006577)4.53009912
51acylglycerol homeostasis (GO:0055090)4.47277659
52triglyceride homeostasis (GO:0070328)4.47277659
53plasma lipoprotein particle remodeling (GO:0034369)4.46163993
54protein-lipid complex remodeling (GO:0034368)4.46163993
55macromolecular complex remodeling (GO:0034367)4.46163993
56alpha-amino acid catabolic process (GO:1901606)4.46002792
57cellular response to gonadotropin stimulus (GO:0071371)4.45656452
58phospholipid efflux (GO:0033700)4.44784164
59regulation of cholesterol esterification (GO:0010872)4.40517452
60bile acid and bile salt transport (GO:0015721)4.34021450
61coenzyme catabolic process (GO:0009109)4.32929188
62indolalkylamine metabolic process (GO:0006586)4.23767982
63cellular ketone body metabolic process (GO:0046950)4.20720241
64plasma lipoprotein particle clearance (GO:0034381)4.19363377
65cellular biogenic amine catabolic process (GO:0042402)4.15657416
66amine catabolic process (GO:0009310)4.15657416
67cellular glucuronidation (GO:0052695)4.13438724
68imidazole-containing compound metabolic process (GO:0052803)4.13275561
69negative regulation of sterol transport (GO:0032372)4.12981722
70negative regulation of cholesterol transport (GO:0032375)4.12981722
71cellular amino acid catabolic process (GO:0009063)4.11871198
72ethanol oxidation (GO:0006069)4.06330512
73Leydig cell differentiation (GO:0033327)4.05082935
74glycine metabolic process (GO:0006544)4.01595110
75cholesterol efflux (GO:0033344)3.99526337
76glutamate metabolic process (GO:0006536)3.95423230
77cellular modified amino acid catabolic process (GO:0042219)3.93875792
78benzene-containing compound metabolic process (GO:0042537)3.91454044
79response to epinephrine (GO:0071871)3.90684337
80serine family amino acid metabolic process (GO:0009069)3.88808859
81response to gonadotropin (GO:0034698)3.87647987
82fibrinolysis (GO:0042730)3.86770550
83acetyl-CoA metabolic process (GO:0006084)3.77642562
84dicarboxylic acid biosynthetic process (GO:0043650)3.77227468
85low-density lipoprotein particle remodeling (GO:0034374)3.74304329
86phospholipid homeostasis (GO:0055091)3.74106697
87negative regulation of lipase activity (GO:0060192)3.72698787
88arginine metabolic process (GO:0006525)3.72518377
89short-chain fatty acid metabolic process (GO:0046459)3.71881894
90positive regulation of hormone biosynthetic process (GO:0046886)3.71324065
91protein heterotrimerization (GO:0070208)3.69333133
92glucuronate metabolic process (GO:0019585)3.68053183
93uronic acid metabolic process (GO:0006063)3.68053183
94positive regulation of lipid catabolic process (GO:0050996)3.67914289
95plasma lipoprotein particle assembly (GO:0034377)3.67067033
96drug catabolic process (GO:0042737)3.66951507
97carboxylic acid catabolic process (GO:0046395)3.66457908
98organic acid catabolic process (GO:0016054)3.66457908
99aldehyde catabolic process (GO:0046185)3.65228820
100regulation of transforming growth factor beta2 production (GO:0032909)3.64503809
101serine family amino acid biosynthetic process (GO:0009070)3.62790605
102ketone body metabolic process (GO:1902224)3.62447477
103hemidesmosome assembly (GO:0031581)3.61651688
104blood coagulation, intrinsic pathway (GO:0007597)3.61501334
105cytolysis (GO:0019835)3.61409288
106cofactor catabolic process (GO:0051187)3.61011605
107cholesterol homeostasis (GO:0042632)3.60779561
108regulation of bile acid biosynthetic process (GO:0070857)3.60368646
109complement activation (GO:0006956)3.57795240
110complement activation, classical pathway (GO:0006958)3.57628848
111very-low-density lipoprotein particle assembly (GO:0034379)3.56570932
112positive regulation of triglyceride lipase activity (GO:0061365)3.56546143
113positive regulation of lipoprotein lipase activity (GO:0051006)3.56546143
114protein activation cascade (GO:0072376)3.55998160
115sterol homeostasis (GO:0055092)3.54543853
116adhesion of symbiont to host (GO:0044406)3.53841771
117regulation of cholesterol homeostasis (GO:2000188)3.51852827
118hormone biosynthetic process (GO:0042446)3.51780821
119fatty acid oxidation (GO:0019395)3.47334013
120retina vasculature morphogenesis in camera-type eye (GO:0061299)3.47313136
121monocarboxylic acid catabolic process (GO:0072329)3.47222000
1222-oxoglutarate metabolic process (GO:0006103)3.46806944
123fatty acid beta-oxidation (GO:0006635)3.46515263
124regulation of cholesterol storage (GO:0010885)3.46405136
125cellular response to toxic substance (GO:0097237)3.42037625
126cellular response to cadmium ion (GO:0071276)3.38330789
127cell-substrate junction assembly (GO:0007044)3.26206587
128cytoskeletal anchoring at plasma membrane (GO:0007016)3.22473698
129cell adhesion mediated by integrin (GO:0033627)3.21685687
130vascular endothelial growth factor signaling pathway (GO:0038084)3.20531853
131regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14078692
132cellular response to hepatocyte growth factor stimulus (GO:0035729)3.13447132
133response to hepatocyte growth factor (GO:0035728)3.13447132
134regulation of gonadotropin secretion (GO:0032276)3.12136132
135regulation of steroid hormone biosynthetic process (GO:0090030)3.09718499
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.09212781
137mesenchymal-epithelial cell signaling (GO:0060638)3.03270805
138androgen metabolic process (GO:0008209)3.02918668
139response to water (GO:0009415)3.02292795
140phagocytosis, recognition (GO:0006910)3.02238028
141mesodermal cell differentiation (GO:0048333)3.02126576
142response to insecticide (GO:0017085)3.01185143
143negative regulation of fatty acid transport (GO:2000192)2.99084584
144endocrine hormone secretion (GO:0060986)2.98490658
145negative regulation of smooth muscle cell migration (GO:0014912)2.97698910
146toxin metabolic process (GO:0009404)2.96531469
147response to corticosterone (GO:0051412)2.95169029
148triglyceride catabolic process (GO:0019433)2.93597669
149protein localization to endosome (GO:0036010)2.92995206
150positive regulation of triglyceride biosynthetic process (GO:0010867)2.91739140
151extracellular matrix assembly (GO:0085029)2.90250784
152biotin metabolic process (GO:0006768)2.84540633
153chondrocyte proliferation (GO:0035988)2.84311002
154stress fiber assembly (GO:0043149)2.82375849
155cellular response to monoamine stimulus (GO:0071868)2.80602669
156cellular response to catecholamine stimulus (GO:0071870)2.80602669
157endothelial cell chemotaxis (GO:0035767)2.79440175
158response to phenylpropanoid (GO:0080184)2.78878406
159skin morphogenesis (GO:0043589)2.76568218
160blood vessel endothelial cell migration (GO:0043534)2.76092297
161regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73455887
162positive regulation of hormone metabolic process (GO:0032352)2.73016319
163regulation of glucose import in response to insulin stimulus (GO:2001273)2.72836377
164desmosome organization (GO:0002934)2.72358148
165adrenal gland development (GO:0030325)2.71904002
166iron ion import (GO:0097286)2.71714181
167adherens junction assembly (GO:0034333)2.69686188
168cellular response to vitamin (GO:0071295)2.68429571
169positive regulation of triglyceride metabolic process (GO:0090208)2.67376478
170focal adhesion assembly (GO:0048041)2.67372309
171cell-substrate adherens junction assembly (GO:0007045)2.67372309
172substrate-dependent cell migration (GO:0006929)2.66362522
173cell migration involved in sprouting angiogenesis (GO:0002042)2.65174339
174apoptotic cell clearance (GO:0043277)2.64917933
175endodermal cell differentiation (GO:0035987)2.61481702
176regulation of triglyceride biosynthetic process (GO:0010866)2.61212350
177regulation of sequestering of triglyceride (GO:0010889)2.60860830
178acylglycerol catabolic process (GO:0046464)2.60593710
179neutral lipid catabolic process (GO:0046461)2.60593710
180regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.59792245
181negative regulation of macrophage differentiation (GO:0045650)2.58876165
182regulation of apoptotic cell clearance (GO:2000425)2.58845210
183response to mineralocorticoid (GO:0051385)2.56707892
184ovulation (GO:0030728)2.56662754
185intracellular lipid transport (GO:0032365)2.51495089
186response to growth hormone (GO:0060416)2.50912604
187import into cell (GO:0098657)2.49555240
188positive regulation of steroid biosynthetic process (GO:0010893)2.48521300
189growth hormone receptor signaling pathway (GO:0060396)2.47943960
190positive regulation of cholesterol efflux (GO:0010875)2.47542344
191cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44247866
192positive regulation of male gonad development (GO:2000020)2.43393836
193protein localization to cell surface (GO:0034394)2.43123581
194cellular response to interferon-alpha (GO:0035457)2.42888358
195regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.41731327
196positive regulation of nitric-oxide synthase activity (GO:0051000)2.41561824
197glucocorticoid biosynthetic process (GO:0006704)10.4460593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.75200225
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.65502305
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.41570423
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.11467705
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.02903815
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.90188921
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.44647819
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93501391
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36054671
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.10456739
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.28209751
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08551316
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8917578
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91731736
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88396902
16* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87550722
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76249260
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75875371
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75576505
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71663373
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71663373
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68047112
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65788676
24CJUN_26792858_Chip-Seq_BT549_Human1.63904362
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.63350294
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61555723
27CLOCK_20551151_ChIP-Seq_293T_Human1.60940867
28GATA1_22025678_ChIP-Seq_K562_Human1.55367981
29HTT_18923047_ChIP-ChIP_STHdh_Human1.51528336
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.47907154
31NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44628849
32BRD4_25478319_ChIP-Seq_HGPS_Human1.41982582
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41715028
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39613464
35PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.37696986
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.37017687
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.35429939
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.33338151
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31360439
40* KDM2B_26808549_Chip-Seq_K562_Human1.30641362
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30050913
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.29998458
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29928599
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29055982
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28156229
46AHR_22903824_ChIP-Seq_MCF-7_Human1.27983079
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27659641
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27596894
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27387712
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26721488
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24892841
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23000474
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22913829
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21026792
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.20888065
56RACK7_27058665_Chip-Seq_MCF-7_Human1.20653041
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19920362
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15729376
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14265269
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09202373
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.08348111
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07139538
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06824121
64TP53_16413492_ChIP-PET_HCT116_Human1.06319707
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05711006
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04100444
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.03638980
68* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03041338
69ATF3_27146783_Chip-Seq_COLON_Human1.02882905
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01752511
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00264589
72WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99766599
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99239388
74ESR1_20079471_ChIP-ChIP_T-47D_Human0.98764571
75GATA4_25053715_ChIP-Seq_YYC3_Human0.98604484
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98324642
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98135269
78SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98119677
79TP53_22127205_ChIP-Seq_IMR90_Human0.97499177
80ARNT_22903824_ChIP-Seq_MCF-7_Human0.97094929
81ESR1_21235772_ChIP-Seq_MCF-7_Human0.93449691
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89067237
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89067237
84SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88876432
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88810759
86* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88589998
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88183001
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87071818
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85837862
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84131746
91MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83969236
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83450266
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83432649
94ZNF263_19887448_ChIP-Seq_K562_Human0.82941701
95* RUNX1_27514584_Chip-Seq_MCF-7_Human0.82564168
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80940869
97CEBPB_22108803_ChIP-Seq_LS180_Human0.72299993
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72270678
99FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72016336
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.71139985
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70290774
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69884273
103BCAT_22108803_ChIP-Seq_LS180_Human0.65585998
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65557122
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65523182
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.64341980
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.64012996
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63740206
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62944979
110EGR1_19032775_ChIP-ChIP_M12_Human0.61774806
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61278933
112CBP_21632823_ChIP-Seq_H3396_Human0.60370969
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.59600200
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59453352
115SOX2_20726797_ChIP-Seq_SW620_Human0.59218740
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58539773
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.57641519
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57574032
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56704246
120STAT1_17558387_ChIP-Seq_HELA_Human0.54941560
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.53701810
122TAF15_26573619_Chip-Seq_HEK293_Human0.53280884
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53176304
124* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53002047
125* AR_20517297_ChIP-Seq_VCAP_Human0.52874220
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.52039704
127* TBX20_22328084_ChIP-Seq_HEART_Mouse0.52008883
128* TBX20_22080862_ChIP-Seq_HEART_Mouse0.52008883
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.51855013
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.51409801
131P53_21459846_ChIP-Seq_SAOS-2_Human0.50846671
132ESET_19884257_ChIP-Seq_ESCs_Mouse0.50089235
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.49536830
134* GATA2_19941826_ChIP-Seq_K562_Human0.49446647
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.49376360
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.49254176
137CDX2_22108803_ChIP-Seq_LS180_Human0.48997436
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48900431
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.48208902
140* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.48079873
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.47618964
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.46920741
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46602887
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46599248
145* TP63_23658742_ChIP-Seq_EP156T_Human0.46346903
146MYC_19915707_ChIP-ChIP_AK7_Human0.46010001
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.45934165
148LXR_22292898_ChIP-Seq_THP-1_Human0.45775052
149TAF2_19829295_ChIP-Seq_ESCs_Human0.45576654
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45105246
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.44988767
152GATA6_25053715_ChIP-Seq_YYC3_Human0.44410248
153ZNF217_24962896_ChIP-Seq_MCF-7_Human0.44368627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.00073010
2MP0005360_urolithiasis7.12215709
3MP0005085_abnormal_gallbladder_physiolo6.17957530
4MP0005365_abnormal_bile_salt5.98626549
5MP0008875_abnormal_xenobiotic_pharmacok4.73571475
6MP0008438_abnormal_cutaneous_collagen4.60015204
7MP0003806_abnormal_nucleotide_metabolis4.00502415
8MP0003252_abnormal_bile_duct3.80456006
9MP0010329_abnormal_lipoprotein_level3.44444438
10MP0005083_abnormal_biliary_tract3.11252112
11MP0003566_abnormal_cell_adhesion3.06862668
12MP0004272_abnormal_basement_membrane2.88770945
13MP0009840_abnormal_foam_cell2.88500649
14MP0008004_abnormal_stomach_pH2.86828753
15MP0003279_aneurysm2.73139985
16MP0003195_calcinosis2.70550292
17MP0001666_abnormal_nutrient_absorption2.57782866
18MP0005332_abnormal_amino_acid2.57546018
19MP0003191_abnormal_cellular_cholesterol2.40275281
20MP0003950_abnormal_plasma_membrane2.14959848
21MP0002118_abnormal_lipid_homeostasis2.09684696
22MP0000609_abnormal_liver_physiology2.07891841
23MP0010352_gastrointestinal_tract_polyps2.04882851
24MP0002138_abnormal_hepatobiliary_system2.04266574
25MP0004019_abnormal_vitamin_homeostasis2.03631576
26MP0005375_adipose_tissue_phenotype1.98644893
27MP0002909_abnormal_adrenal_gland1.97961823
28MP0000013_abnormal_adipose_tissue1.91405141
29MP0003868_abnormal_feces_composition1.86722049
30MP0005503_abnormal_tendon_morphology1.85484718
31MP0009780_abnormal_chondrocyte_physiolo1.85454455
32MP0005451_abnormal_body_composition1.81009811
33MP0005319_abnormal_enzyme/_coenzyme1.77675464
34MP0003091_abnormal_cell_migration1.74373792
35MP0005023_abnormal_wound_healing1.73574400
36MP0006138_congestive_heart_failure1.66608046
37MP0001879_abnormal_lymphatic_vessel1.63906755
38MP0005409_darkened_coat_color1.63082076
39MP0002896_abnormal_bone_mineralization1.63029615
40MP0001958_emphysema1.61818958
41MP0009697_abnormal_copulation1.56751042
42MP0005584_abnormal_enzyme/coenzyme_acti1.52774358
43MP0000003_abnormal_adipose_tissue1.49919372
44MP0002166_altered_tumor_susceptibility1.49361961
45MP0001764_abnormal_homeostasis1.47901220
46MP0002006_tumorigenesis1.44774322
47MP0005623_abnormal_meninges_morphology1.40591843
48MP0003011_delayed_dark_adaptation1.40350729
49MP0000751_myopathy1.39981955
50MP0005595_abnormal_vascular_smooth1.37920756
51MP0003941_abnormal_skin_development1.37319527
52MP0003705_abnormal_hypodermis_morpholog1.33242564
53MP0005076_abnormal_cell_differentiation1.31137507
54MP0000767_abnormal_smooth_muscle1.30887770
55MP0002998_abnormal_bone_remodeling1.26036553
56MP0003959_abnormal_lean_body1.26015184
57MP0005164_abnormal_response_to1.25702777
58MP0004130_abnormal_muscle_cell1.25349257
59MP0003656_abnormal_erythrocyte_physiolo1.25257531
60MP0002933_joint_inflammation1.23936095
61MP0002877_abnormal_melanocyte_morpholog1.22677483
62MP0004084_abnormal_cardiac_muscle1.21000020
63MP0002254_reproductive_system_inflammat1.20775493
64MP0005508_abnormal_skeleton_morphology1.19307944
65MP0005647_abnormal_sex_gland1.18347034
66MP0002009_preneoplasia1.17477909
67MP0003186_abnormal_redox_activity1.17405988
68MP0009643_abnormal_urine_homeostasis1.16969580
69MP0002108_abnormal_muscle_morphology1.16227652
70MP0005670_abnormal_white_adipose1.14753230
71MP0010368_abnormal_lymphatic_system1.14552508
72MP0002796_impaired_skin_barrier1.14343600
73MP0002970_abnormal_white_adipose1.12491112
74MP0009764_decreased_sensitivity_to1.08284989
75MP0000598_abnormal_liver_morphology1.07156132
76MP0001881_abnormal_mammary_gland0.99105055
77MP0003828_pulmonary_edema0.98246357
78MP0005257_abnormal_intraocular_pressure0.97126410
79MP0002971_abnormal_brown_adipose0.96917492
80MP0002295_abnormal_pulmonary_circulatio0.96511591
81MP0009763_increased_sensitivity_to0.92526738
82MP0000762_abnormal_tongue_morphology0.91955302
83MP0003300_gastrointestinal_ulcer0.91477931
84MP0006036_abnormal_mitochondrial_physio0.90981741
85MP0000627_abnormal_mammary_gland0.90436816
86MP0000604_amyloidosis0.89533830
87MP0000249_abnormal_blood_vessel0.89077315
88MP0004381_abnormal_hair_follicle0.88677746
89MP0005636_abnormal_mineral_homeostasis0.88466973
90MP0004858_abnormal_nervous_system0.88094103
91MP0001915_intracranial_hemorrhage0.84001084
92MP0008469_abnormal_protein_level0.83383279
93MP0005165_increased_susceptibility_to0.81891084
94MP0002876_abnormal_thyroid_physiology0.81758997
95MP0000733_abnormal_muscle_development0.81446454
96MP0002128_abnormal_blood_circulation0.81262996
97MP0001614_abnormal_blood_vessel0.80387167
98MP0009642_abnormal_blood_homeostasis0.80221186
99MP0002078_abnormal_glucose_homeostasis0.79361934
100MP0005334_abnormal_fat_pad0.79273184
101MP0004233_abnormal_muscle_weight0.78407815
102MP0001299_abnormal_eye_distance/0.77892276
103MP0004883_abnormal_blood_vessel0.77390132
104MP0002837_dystrophic_cardiac_calcinosis0.76782147
105MP0000163_abnormal_cartilage_morphology0.76601793
106MP0000467_abnormal_esophagus_morphology0.76336766
107MP0005390_skeleton_phenotype0.76025911
108MP0005408_hypopigmentation0.75988997
109MP0005220_abnormal_exocrine_pancreas0.74497425
110MP0004036_abnormal_muscle_relaxation0.74071919
111MP0005376_homeostasis/metabolism_phenot0.73231761
112MP0005084_abnormal_gallbladder_morpholo0.73062042
113MP0009250_abnormal_appendicular_skeleto0.73033702
114MP0000579_abnormal_nail_morphology0.72570731
115MP0005666_abnormal_adipose_tissue0.72409843
116MP0001533_abnormal_skeleton_physiology0.72178976
117MP0010771_integument_phenotype0.70828390
118MP0001849_ear_inflammation0.70704312
119MP0001661_extended_life_span0.70592699
120MP0006054_spinal_hemorrhage0.70140232
121MP0000343_altered_response_to0.69719850
122MP0004782_abnormal_surfactant_physiolog0.69615972
123MP0002115_abnormal_skeleton_extremities0.68779694
124MP0005535_abnormal_body_temperature0.68042821
125MP0009765_abnormal_xenobiotic_induced0.67585062
126MP0005266_abnormal_metabolism0.66373006
127MP0003724_increased_susceptibility_to0.64785248
128MP0002060_abnormal_skin_morphology0.60559680
129MP0004185_abnormal_adipocyte_glucose0.60007835
130MP0010234_abnormal_vibrissa_follicle0.58655305
131MP0002269_muscular_atrophy0.58530344
132MP0003690_abnormal_glial_cell0.57933667
133MP0006035_abnormal_mitochondrial_morpho0.57905247
134MP0005448_abnormal_energy_balance0.56801300
135MP0000427_abnormal_hair_cycle0.52553066
136MP0009053_abnormal_anal_canal0.51937938
137MP0001756_abnormal_urination0.51696643
138MP0005275_abnormal_skin_tensile0.50164742
139MP0005501_abnormal_skin_physiology0.48864239
140MP0003646_muscle_fatigue0.48769861
141MP0003453_abnormal_keratinocyte_physiol0.45677545
142MP0001243_abnormal_dermal_layer0.45593989
143MP0003329_amyloid_beta_deposits0.43359215
144MP0004947_skin_inflammation0.42990849
145MP0000639_abnormal_adrenal_gland0.42227588
146MP0002928_abnormal_bile_duct0.41990881
147MP0000749_muscle_degeneration0.41883727
148MP0005395_other_phenotype0.41594620
149MP0000747_muscle_weakness0.41120014
150MP0000647_abnormal_sebaceous_gland0.40914629
151MP0002136_abnormal_kidney_physiology0.39901061
152MP0005464_abnormal_platelet_physiology0.39842619
153MP0009115_abnormal_fat_cell0.39684333
154MP0004145_abnormal_muscle_electrophysio0.39239240
155MP0003638_abnormal_response/metabolism_0.38714517
156MP0000230_abnormal_systemic_arterial0.37279856
157MP0009672_abnormal_birth_weight0.37089715
158MP0003436_decreased_susceptibility_to0.36559826
159MP0005248_abnormal_Harderian_gland0.36225675
160MP0009384_cardiac_valve_regurgitation0.36199020
161MP0008874_decreased_physiological_sensi0.34797588
162MP0002168_other_aberrant_phenotype0.34377881
163MP0003953_abnormal_hormone_level0.34140760
164MP0001216_abnormal_epidermal_layer0.34062608
165MP0003075_altered_response_to0.33939388
166MP0008873_increased_physiological_sensi0.33124739

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.14250884
2Deep venous thrombosis (HP:0002625)7.02210071
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.78289070
4Prolonged partial thromboplastin time (HP:0003645)6.18028960
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.17415793
6Xanthomatosis (HP:0000991)6.02024628
7Hypobetalipoproteinemia (HP:0003563)5.95722755
8Hyperlipoproteinemia (HP:0010980)5.29793798
9Complement deficiency (HP:0004431)5.23312181
10Protrusio acetabuli (HP:0003179)4.87074287
11Hypolipoproteinemia (HP:0010981)4.69321560
12Joint hemorrhage (HP:0005261)4.54703604
13Epidermoid cyst (HP:0200040)4.52581938
14Hyperammonemia (HP:0001987)4.41796937
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32479212
16Hypoalphalipoproteinemia (HP:0003233)4.29318180
17Hyperglycinemia (HP:0002154)4.26423317
18Ketosis (HP:0001946)4.23993672
19Abnormality of the common coagulation pathway (HP:0010990)4.13987330
20Cervical subluxation (HP:0003308)4.09366589
21Premature rupture of membranes (HP:0001788)4.04815695
22Fat malabsorption (HP:0002630)4.02795375
23Vascular tortuosity (HP:0004948)4.00893422
24Arterial tortuosity (HP:0005116)3.97159527
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.95551697
26Abnormality of methionine metabolism (HP:0010901)3.95344578
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92273929
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.86673098
29Hyperglycinuria (HP:0003108)3.83550580
30Abnormality of glycine metabolism (HP:0010895)3.81545230
31Abnormality of serine family amino acid metabolism (HP:0010894)3.81545230
32Hypoglycemic coma (HP:0001325)3.80732697
33Abnormality of complement system (HP:0005339)3.77692945
34Abnormality of the intrinsic pathway (HP:0010989)3.61266478
35Conjugated hyperbilirubinemia (HP:0002908)3.61010385
36Hypercholesterolemia (HP:0003124)3.42376634
37Enlarged penis (HP:0000040)3.41979824
38Renal salt wasting (HP:0000127)3.34931482
39Abnormality of fatty-acid metabolism (HP:0004359)3.32903476
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29638488
41Ankle contracture (HP:0006466)3.24973993
42Decreased circulating renin level (HP:0003351)3.24101877
43Abnormality of pyrimidine metabolism (HP:0004353)3.21090382
44Hyperbilirubinemia (HP:0002904)3.15901971
45Acanthosis nigricans (HP:0000956)3.15083913
46Aortic aneurysm (HP:0004942)3.11612951
47Ketoacidosis (HP:0001993)3.08457841
48Steatorrhea (HP:0002570)3.07055907
49Abnormality of carpal bone ossification (HP:0006257)3.05669392
50Spinal rigidity (HP:0003306)3.00249464
51Overgrowth (HP:0001548)2.99407125
52Wormian bones (HP:0002645)2.99200205
53Abnormality of nucleobase metabolism (HP:0010932)2.97779418
54Myocardial infarction (HP:0001658)2.95598880
55Abnormality of serum amino acid levels (HP:0003112)2.93510371
56Relative macrocephaly (HP:0004482)2.88315418
57Abnormality of purine metabolism (HP:0004352)2.86123936
58Delayed CNS myelination (HP:0002188)2.85871520
59Aortic dissection (HP:0002647)2.78744610
60Hepatocellular carcinoma (HP:0001402)2.78713563
61Hyperaldosteronism (HP:0000859)2.78277388
62Metabolic acidosis (HP:0001942)2.77236503
63Atrophic scars (HP:0001075)2.69214846
64Systemic lupus erythematosus (HP:0002725)2.68950106
65Hypochromic microcytic anemia (HP:0004840)2.67182594
66Abnormal ossification of hand bones (HP:0005921)2.66129903
67Spontaneous abortion (HP:0005268)2.65266416
68Vascular calcification (HP:0004934)2.65198862
69Abnormal gallbladder morphology (HP:0012437)2.65023860
70Soft skin (HP:0000977)2.63149965
71Skin nodule (HP:0200036)2.62950423
72Cholelithiasis (HP:0001081)2.61081196
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60199869
74Dicarboxylic aciduria (HP:0003215)2.60199869
75Shallow orbits (HP:0000586)2.59872187
76Fragile skin (HP:0001030)2.59352521
77Vertebral compression fractures (HP:0002953)2.59077863
78Follicular hyperkeratosis (HP:0007502)2.57586513
79Gout (HP:0001997)2.55782689
80Increased variability in muscle fiber diameter (HP:0003557)2.54481790
81Osteolytic defects of the hand bones (HP:0009699)2.52984079
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.52984079
83Spinal cord lesions (HP:0100561)2.49815467
84Syringomyelia (HP:0003396)2.49815467
85Bronchomalacia (HP:0002780)2.48222757
86Bladder diverticulum (HP:0000015)2.48078538
87Lethargy (HP:0001254)2.46952260
88Ulnar bowing (HP:0003031)2.42535288
89Hypoglycemic seizures (HP:0002173)2.41781581
90Acanthocytosis (HP:0001927)2.39970722
91Abnormal hand bone ossification (HP:0010660)2.39707044
92Ankyloglossia (HP:0010296)2.39431115
93Cardiovascular calcification (HP:0011915)2.37269741
94Broad face (HP:0000283)2.36808691
95Cerebral edema (HP:0002181)2.34963898
96Cholecystitis (HP:0001082)2.34296429
97Abnormal gallbladder physiology (HP:0012438)2.34296429
98Mitral stenosis (HP:0001718)2.30374518
99Short nail (HP:0001799)2.29811012
100Esophageal varix (HP:0002040)2.29586302
101Neonatal onset (HP:0003623)2.29573360
102Glomerulonephritis (HP:0000099)2.28495865
103Persistence of primary teeth (HP:0006335)2.27040140
104Short humerus (HP:0005792)2.22938073
105Recurrent gram-negative bacterial infections (HP:0005420)2.22679772
106Accelerated skeletal maturation (HP:0005616)2.22246106
107Increased connective tissue (HP:0009025)2.21079098
108Joint laxity (HP:0001388)2.20623091
109Myoglobinuria (HP:0002913)2.20386446
110Spinal cord compression (HP:0002176)2.17219376
111Malnutrition (HP:0004395)2.13105793
112Abnormality of oral frenula (HP:0000190)2.12569359
113Flat acetabular roof (HP:0003180)2.12480805
114Blue sclerae (HP:0000592)2.12467439
115Late onset (HP:0003584)2.12165209
116Abnormality of the gallbladder (HP:0005264)2.11569839
117Spastic diplegia (HP:0001264)2.11328394
118Abnormality of skeletal muscle fiber size (HP:0012084)2.09268529
119Pancreatitis (HP:0001733)2.09204028
120Hemorrhage of the eye (HP:0011885)2.09011464
121Irritability (HP:0000737)2.08655123
122Amyloidosis (HP:0011034)2.08298037
123Short clavicles (HP:0000894)2.07744925
124Cerebral aneurysm (HP:0004944)2.07299538
125Wrist flexion contracture (HP:0001239)2.06200895
126Gingival bleeding (HP:0000225)2.05004167
127Coxa vara (HP:0002812)2.04356369
128Broad metatarsal (HP:0001783)2.01652660
129Hyperinsulinemic hypoglycemia (HP:0000825)2.01310422
130Delayed closure of the anterior fontanelle (HP:0001476)2.00589684
131Exercise-induced myalgia (HP:0003738)2.00583107
132Brushfield spots (HP:0001088)2.00172868
133Menorrhagia (HP:0000132)2.00076166
134Vomiting (HP:0002013)1.99773463
135Aneurysm (HP:0002617)1.99164582
136Large earlobe (HP:0009748)1.97641808
137Increased purine levels (HP:0004368)1.97496029
138Hyperuricemia (HP:0002149)1.97496029
139Enlarged kidneys (HP:0000105)1.96607402
140Sensorimotor neuropathy (HP:0007141)1.96242235
141Hypoplasia of the uterus (HP:0000013)1.95740427
142Opisthotonus (HP:0002179)1.94758731
143Aortic valve stenosis (HP:0001650)1.93444692
144Generalized aminoaciduria (HP:0002909)1.93051912
145Adrenal overactivity (HP:0002717)1.92738337
146Aplasia/Hypoplasia of the clavicles (HP:0006710)1.91611699
147Renal cortical cysts (HP:0000803)1.90452361
148Thrombophlebitis (HP:0004418)1.90136400
149Dilatation of the ascending aorta (HP:0005111)1.90115082
150Abnormality of proline metabolism (HP:0010907)1.89395646
151Hydroxyprolinuria (HP:0003080)1.89395646
152Hyperglycemia (HP:0003074)1.89341225
153Precocious puberty (HP:0000826)1.88597568
154Rhizomelia (HP:0008905)1.88074135
155Mitral valve prolapse (HP:0001634)1.87789050
156Fragile nails (HP:0001808)1.86344027
157Poikilocytosis (HP:0004447)1.86327341
158Obstructive sleep apnea (HP:0002870)1.85752005
159Rickets (HP:0002748)1.85329203
160Vertebral arch anomaly (HP:0008438)1.85049562
161Oligomenorrhea (HP:0000876)1.84931805
162Rhabdomyolysis (HP:0003201)1.83613965
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.82943540
164Aplasia/hypoplasia of the humerus (HP:0006507)1.82523765
165Spondylolisthesis (HP:0003302)1.82216185
166Disproportionate tall stature (HP:0001519)1.81860114
167Abnormality of iron homeostasis (HP:0011031)1.81311573
168Advanced eruption of teeth (HP:0006288)1.80577046
169Genu recurvatum (HP:0002816)1.80387561
170Abnormality of transition element cation homeostasis (HP:0011030)1.78759104
171Neonatal death (HP:0003811)1.78361153
172Growth hormone excess (HP:0000845)1.78354772
173Striae distensae (HP:0001065)1.78200612
174Elevated hepatic transaminases (HP:0002910)1.77925278
175Mitral regurgitation (HP:0001653)1.77285258
176Abnormal enzyme/coenzyme activity (HP:0012379)1.76955630
177Knee flexion contracture (HP:0006380)1.75917462
178Neurofibrillary tangles (HP:0002185)1.75860096
179Hypophosphatemic rickets (HP:0004912)1.74386266
180Cupped ribs (HP:0000887)1.74337602
181Abnormality of the acetabulum (HP:0003170)1.72666798
182Natal tooth (HP:0000695)1.72423222
183Ovoid vertebral bodies (HP:0003300)1.72333850
184Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71561644
185Delayed cranial suture closure (HP:0000270)1.71221693
186Onycholysis (HP:0001806)1.71088806
187Aortic regurgitation (HP:0001659)1.70403959
188Ectopia lentis (HP:0001083)1.69048835
189Coarse hair (HP:0002208)1.67556611
190Coronal craniosynostosis (HP:0004440)1.67050302
191Broad ribs (HP:0000885)1.66770364
192Urinary glycosaminoglycan excretion (HP:0003541)1.66425833
193Mucopolysacchariduria (HP:0008155)1.66425833
194Limited hip movement (HP:0008800)1.64327492
195Cerebral inclusion bodies (HP:0100314)1.63229365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.33474752
2SIK14.04079397
3ERN13.83772779
4AKT33.80038679
5FGFR43.64974650
6PDGFRA3.54634562
7INSRR3.15755714
8NTRK12.80135613
9PIK3CG2.75320523
10TAOK32.47177309
11DDR22.39615322
12MAP2K42.30062174
13OBSCN2.26709748
14ERBB42.22674613
15EPHA22.04857821
16MYLK1.96123705
17NEK91.93860462
18MST1R1.92981288
19LATS11.88613681
20TRIB31.84518766
21PRPF4B1.71504649
22MAP3K71.69229291
23PKN21.68100195
24MAP2K31.66873332
25MAPK111.65636305
26ICK1.65342394
27EEF2K1.65033513
28TYK21.62571675
29PDGFRB1.61269743
30TIE11.58201595
31KDR1.57078470
32PAK21.49823343
33PINK11.46593980
34TTN1.45289538
35PTK61.45043396
36PRKAA21.42257946
37FRK1.40980120
38PHKG21.32137506
39PHKG11.32137506
40STK381.27583992
41FLT31.26634934
42EPHB11.24965775
43MAPK121.24722856
44MAP3K31.22038300
45FGFR21.21678312
46CDC42BPA1.20539204
47MAP3K131.18843620
48PAK41.13837020
49ABL21.12263245
50MAP3K141.10631435
51JAK21.07281902
52RIPK11.07227765
53JAK11.06865373
54MELK1.05536730
55CDK121.05259156
56TBK11.01731794
57IRAK31.00720906
58EPHA31.00585918
59DAPK21.00217752
60PIK3CA0.98858152
61PRKD20.98364436
62TRPM70.95491912
63MAP2K60.95080158
64STK38L0.94733469
65TGFBR20.92481158
66CAMK1D0.89115902
67MAPK40.87886997
68PRKAA10.86666815
69TAOK20.85713051
70PTK2B0.85092539
71BMX0.81800784
72LMTK20.79191132
73ZAP700.76887150
74PRKD30.75722777
75DMPK0.73862297
76ERBB20.73466704
77MAPK150.73008256
78CDK60.71342961
79MAP3K110.70992759
80PRKCZ0.69667336
81FGFR30.67360849
82GSK3A0.67315905
83JAK30.65730762
84SCYL20.65326079
85CSK0.63524024
86PRKACG0.62859218
87CAMK2G0.62827642
88MAPK70.61673878
89PKN10.61144546
90RPS6KA20.60523878
91GRK10.59348548
92MAP3K100.58956535
93MAP3K50.58762998
94DYRK1B0.58584395
95MAPKAPK30.58235438
96MET0.57959241
97SGK30.57702898
98CAMK10.54301635
99PDK30.53357918
100PDK40.53357918
101PDPK10.48444063
102ROCK10.47746673
103SMG10.46008119
104SGK20.45463275
105PRKCQ0.45304167
106FER0.44297996
107ROCK20.43482769
108CLK10.42891934
109CAMK1G0.42789907
110PRKG20.42774633
111IKBKE0.42513789
112AKT20.42176016
113MAP3K60.39731456
114PDK20.39175149
115MAP2K10.39066283
116IGF1R0.38898838
117MAPK30.38788733
118MAP2K20.38181143
119MAP3K10.37733213
120SGK2230.36829909
121SGK4940.36829909
122STK30.35118276
123IRAK10.33910925
124PTK20.32341832
125KIT0.32201363
126CDK90.30539502
127CDK70.30482060
128RET0.30161252
129CSF1R0.30133590
130FGFR10.30108000
131MARK20.30017618
132MAPK10.29807823
133PRKCH0.29753806
134YES10.28740752
135GRK60.28290890
136MAP3K20.27826605
137WNK10.27786347
138EGFR0.27772951
139MAP3K120.27765943
140EPHB20.27595478
141INSR0.26422502
142SRC0.26377738
143IRAK20.26291014
144PBK0.26179171
145LATS20.26017266
146MTOR0.25893399
147PRKD10.24540100
148PDK10.24439796
149ABL10.23325570

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.43410795
2Nitrogen metabolism_Homo sapiens_hsa009103.31112674
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26550152
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17969019
5ECM-receptor interaction_Homo sapiens_hsa045122.97034233
6Arginine biosynthesis_Homo sapiens_hsa002202.95340986
7Aldosterone synthesis and secretion_Homo sapiens_hsa049252.76121377
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75294435
9Complement and coagulation cascades_Homo sapiens_hsa046102.68040862
10Tryptophan metabolism_Homo sapiens_hsa003802.67261075
11Fatty acid degradation_Homo sapiens_hsa000712.57537094
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55482004
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52108273
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40230909
15Focal adhesion_Homo sapiens_hsa045102.28609897
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20232044
17Propanoate metabolism_Homo sapiens_hsa006402.17781634
18Peroxisome_Homo sapiens_hsa041462.11481477
19Butanoate metabolism_Homo sapiens_hsa006502.09732350
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08921696
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06010850
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.98307947
23Histidine metabolism_Homo sapiens_hsa003401.94144364
24PPAR signaling pathway_Homo sapiens_hsa033201.93972112
25Fatty acid metabolism_Homo sapiens_hsa012121.92347583
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.87203237
27Chemical carcinogenesis_Homo sapiens_hsa052041.87059317
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85407784
29beta-Alanine metabolism_Homo sapiens_hsa004101.83500627
30Staphylococcus aureus infection_Homo sapiens_hsa051501.75098590
31Retinol metabolism_Homo sapiens_hsa008301.73966149
32Caffeine metabolism_Homo sapiens_hsa002321.73297902
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69956226
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62600888
35Fatty acid elongation_Homo sapiens_hsa000621.60290640
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.59595497
37Phenylalanine metabolism_Homo sapiens_hsa003601.57775696
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55625496
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53774607
40Proteoglycans in cancer_Homo sapiens_hsa052051.49089871
41Selenocompound metabolism_Homo sapiens_hsa004501.47817458
42Bile secretion_Homo sapiens_hsa049761.46345279
43Tyrosine metabolism_Homo sapiens_hsa003501.43228165
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41956462
45Starch and sucrose metabolism_Homo sapiens_hsa005001.41383902
46Pyruvate metabolism_Homo sapiens_hsa006201.37479139
47Sulfur metabolism_Homo sapiens_hsa009201.34980010
48ABC transporters_Homo sapiens_hsa020101.33594874
49Steroid biosynthesis_Homo sapiens_hsa001001.31053219
50Fat digestion and absorption_Homo sapiens_hsa049751.22831663
51Small cell lung cancer_Homo sapiens_hsa052221.22125462
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18069533
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.15459025
54Carbon metabolism_Homo sapiens_hsa012001.13188208
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12949700
56Adherens junction_Homo sapiens_hsa045201.12506573
57Folate biosynthesis_Homo sapiens_hsa007901.11662765
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10966284
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09807557
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08691977
61Biosynthesis of amino acids_Homo sapiens_hsa012301.08586176
62Phospholipase D signaling pathway_Homo sapiens_hsa040721.00346197
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.98543516
64Arginine and proline metabolism_Homo sapiens_hsa003300.98407769
65Protein digestion and absorption_Homo sapiens_hsa049740.97252992
66Chronic myeloid leukemia_Homo sapiens_hsa052200.97065734
67MicroRNAs in cancer_Homo sapiens_hsa052060.97033415
68Prolactin signaling pathway_Homo sapiens_hsa049170.96704586
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95585794
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.94267867
71Dilated cardiomyopathy_Homo sapiens_hsa054140.92857230
72GnRH signaling pathway_Homo sapiens_hsa049120.92567435
73Vitamin digestion and absorption_Homo sapiens_hsa049770.92503149
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.91309081
75Renin secretion_Homo sapiens_hsa049240.90065254
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89163205
77Sulfur relay system_Homo sapiens_hsa041220.88812971
78Vitamin B6 metabolism_Homo sapiens_hsa007500.88346080
79Estrogen signaling pathway_Homo sapiens_hsa049150.85794137
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85744772
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85007655
82Renal cell carcinoma_Homo sapiens_hsa052110.82062701
83Lysine degradation_Homo sapiens_hsa003100.81391481
84Thyroid hormone synthesis_Homo sapiens_hsa049180.77391905
85Thyroid cancer_Homo sapiens_hsa052160.76639117
86Dorso-ventral axis formation_Homo sapiens_hsa043200.75460895
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74740850
88Glycerolipid metabolism_Homo sapiens_hsa005610.74225636
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73319345
90ErbB signaling pathway_Homo sapiens_hsa040120.71752884
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70806239
92Notch signaling pathway_Homo sapiens_hsa043300.70724663
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69311034
94Pathways in cancer_Homo sapiens_hsa052000.68357776
95Gastric acid secretion_Homo sapiens_hsa049710.66952884
96Fatty acid biosynthesis_Homo sapiens_hsa000610.66732204
97VEGF signaling pathway_Homo sapiens_hsa043700.66704605
98TGF-beta signaling pathway_Homo sapiens_hsa043500.63903229
99Rap1 signaling pathway_Homo sapiens_hsa040150.63816706
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.62674695
101Gap junction_Homo sapiens_hsa045400.62157340
102Prostate cancer_Homo sapiens_hsa052150.62034368
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61900429
104Other glycan degradation_Homo sapiens_hsa005110.60902255
105Melanogenesis_Homo sapiens_hsa049160.59746641
106Bladder cancer_Homo sapiens_hsa052190.58408533
107Glutathione metabolism_Homo sapiens_hsa004800.58375182
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58018623
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.57304239
110One carbon pool by folate_Homo sapiens_hsa006700.55222099
111Platelet activation_Homo sapiens_hsa046110.54734490
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54236321
113Inositol phosphate metabolism_Homo sapiens_hsa005620.54218698
114Hippo signaling pathway_Homo sapiens_hsa043900.54014372
115Pentose phosphate pathway_Homo sapiens_hsa000300.53174069
116Melanoma_Homo sapiens_hsa052180.53114924
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52649182
118Long-term potentiation_Homo sapiens_hsa047200.52477465
119Glioma_Homo sapiens_hsa052140.51810845
120Acute myeloid leukemia_Homo sapiens_hsa052210.51050438
121Pancreatic secretion_Homo sapiens_hsa049720.51039169
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50959899
123TNF signaling pathway_Homo sapiens_hsa046680.49520243
124Sphingolipid metabolism_Homo sapiens_hsa006000.48141638
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47096689
126Metabolic pathways_Homo sapiens_hsa011000.44956402
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40826297
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.39249907
129Insulin resistance_Homo sapiens_hsa049310.39044526
130Linoleic acid metabolism_Homo sapiens_hsa005910.34304013
131Prion diseases_Homo sapiens_hsa050200.31183634
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30402467
133Galactose metabolism_Homo sapiens_hsa000520.25451792
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24713615
135Fructose and mannose metabolism_Homo sapiens_hsa000510.21561578
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.19439052
137Glucagon signaling pathway_Homo sapiens_hsa049220.18878437
138AMPK signaling pathway_Homo sapiens_hsa041520.14684023
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02801605
140Ovarian steroidogenesis_Homo sapiens_hsa049130.02772238
141Insulin signaling pathway_Homo sapiens_hsa049100.02463735
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1965532
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1885375
144Pertussis_Homo sapiens_hsa05133-0.1881355
145Renin-angiotensin system_Homo sapiens_hsa04614-0.1743165
146Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1648333
147Amoebiasis_Homo sapiens_hsa05146-0.1522888
148Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1495396
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1474540
150African trypanosomiasis_Homo sapiens_hsa05143-0.1407164
151Ether lipid metabolism_Homo sapiens_hsa00565-0.1353939
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1335145
153Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1327114
154Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1319972
155Circadian rhythm_Homo sapiens_hsa04710-0.1284883
156Regulation of autophagy_Homo sapiens_hsa04140-0.1168749
157Hepatitis C_Homo sapiens_hsa05160-0.1121359
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0658868
159Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0434686

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