C2CD2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61107280
2synaptic vesicle maturation (GO:0016188)5.24062693
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14952936
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04616289
5locomotory exploration behavior (GO:0035641)4.87828483
6vocalization behavior (GO:0071625)4.49871075
7synaptic vesicle exocytosis (GO:0016079)4.32166275
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30622804
9negative regulation of cell killing (GO:0031342)4.30622804
10glutamate secretion (GO:0014047)4.21953303
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17416535
12regulation of synaptic vesicle exocytosis (GO:2000300)4.11287072
13protein localization to synapse (GO:0035418)4.08748004
14regulation of glutamate receptor signaling pathway (GO:1900449)4.07689839
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.07443780
16regulation of neuronal synaptic plasticity (GO:0048168)3.97295129
17regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93122957
18positive regulation of gamma-delta T cell activation (GO:0046645)3.84624206
19neurotransmitter secretion (GO:0007269)3.80932692
20regulation of synaptic vesicle transport (GO:1902803)3.79817301
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.75772860
22regulation of synapse structural plasticity (GO:0051823)3.71698358
23neurotransmitter-gated ion channel clustering (GO:0072578)3.67201039
24positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64197924
25exploration behavior (GO:0035640)3.58948195
26cellular potassium ion homeostasis (GO:0030007)3.54678077
27positive regulation of membrane potential (GO:0045838)3.51502856
28gamma-aminobutyric acid transport (GO:0015812)3.50109589
29layer formation in cerebral cortex (GO:0021819)3.49502285
30dendritic spine morphogenesis (GO:0060997)3.48254618
31tolerance induction (GO:0002507)3.48031120
32neuronal action potential propagation (GO:0019227)3.44746078
33negative regulation of erythrocyte differentiation (GO:0045647)3.43834966
34sodium ion export (GO:0071436)3.43222007
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41059562
36synaptic transmission, glutamatergic (GO:0035249)3.40396622
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39505712
38negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.37777790
39long-term memory (GO:0007616)3.35725609
40modulation by symbiont of host immune response (GO:0052553)3.34029451
41positive regulation by symbiont of host defense response (GO:0052509)3.34029451
42modulation by symbiont of host defense response (GO:0052031)3.34029451
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34029451
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34029451
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.34029451
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32135611
47neuron-neuron synaptic transmission (GO:0007270)3.31947564
48macrophage activation involved in immune response (GO:0002281)3.28148482
49regulation of gamma-delta T cell activation (GO:0046643)3.28134610
50glutamate receptor signaling pathway (GO:0007215)3.27064978
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26490936
52regulation of postsynaptic membrane potential (GO:0060078)3.23056691
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19833541
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17822992
55neurotransmitter transport (GO:0006836)3.17075525
56regulation of dendritic spine morphogenesis (GO:0061001)3.17027329
57activation of protein kinase A activity (GO:0034199)3.16605332
58prepulse inhibition (GO:0060134)3.16564845
59behavioral response to cocaine (GO:0048148)3.14487046
60regulation of synaptic plasticity (GO:0048167)3.14034775
61neuromuscular process controlling balance (GO:0050885)3.10146901
62antigen processing and presentation of endogenous antigen (GO:0019883)3.09543746
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.09301572
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08788004
65positive regulation of neurotransmitter transport (GO:0051590)3.07870118
66neuron cell-cell adhesion (GO:0007158)3.03791542
67glycine transport (GO:0015816)3.03757055
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02183854
69neuromuscular process controlling posture (GO:0050884)3.01111695
70proline transport (GO:0015824)2.99782113
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98281521
72chemosensory behavior (GO:0007635)2.97857069
73regulation of female receptivity (GO:0045924)2.97525703
74regulation of rhodopsin mediated signaling pathway (GO:0022400)2.97280472
75response to histamine (GO:0034776)2.97105849
76signal complex assembly (GO:0007172)2.95942674
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95871547
78activated T cell proliferation (GO:0050798)2.95738328
79dopamine receptor signaling pathway (GO:0007212)2.95716027
80regulation of gamma-delta T cell differentiation (GO:0045586)2.95386366
81striatum development (GO:0021756)2.95139781
82synaptic transmission, dopaminergic (GO:0001963)2.93362505
83regulation of ARF protein signal transduction (GO:0032012)2.92044708
84long-term synaptic potentiation (GO:0060291)2.91937685
85regulation of neurotransmitter levels (GO:0001505)2.91720714
86positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90727260
87cilium or flagellum-dependent cell motility (GO:0001539)2.90039188
88membrane hyperpolarization (GO:0060081)2.89886749
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89211896
90regulation of vesicle fusion (GO:0031338)2.88339852
91behavioral fear response (GO:0001662)2.86741719
92behavioral defense response (GO:0002209)2.86741719
93rhodopsin mediated signaling pathway (GO:0016056)2.86481458
94adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.85629610
95regulation of clathrin-mediated endocytosis (GO:2000369)2.85373576
96regulation of neurotransmitter secretion (GO:0046928)2.83762874
97auditory behavior (GO:0031223)2.83396448
98positive regulation of synapse maturation (GO:0090129)2.82706113
99transmission of nerve impulse (GO:0019226)2.80922244
100positive regulation of mast cell activation (GO:0033005)2.79240512
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.79030975
102positive regulation of neurotransmitter secretion (GO:0001956)2.78476851
103response to auditory stimulus (GO:0010996)2.75717277
104cell communication by electrical coupling (GO:0010644)2.75614980
105regulation of voltage-gated calcium channel activity (GO:1901385)2.75607651
106regulation of B cell receptor signaling pathway (GO:0050855)2.75606687
107response to peptidoglycan (GO:0032494)2.75419977
108cellular sodium ion homeostasis (GO:0006883)2.74207043
109cerebellar Purkinje cell differentiation (GO:0021702)2.72281775
110female mating behavior (GO:0060180)2.71724792
111negative regulation of T cell mediated immunity (GO:0002710)2.70849105
112mating behavior (GO:0007617)2.70560134
113retinal cone cell development (GO:0046549)2.70216796
114fear response (GO:0042596)2.69534777
115axonemal dynein complex assembly (GO:0070286)2.67792298
116regulation of neurotransmitter transport (GO:0051588)2.66911131
117regulation of regulated secretory pathway (GO:1903305)2.66103976
118neuronal ion channel clustering (GO:0045161)2.64993863
119membrane depolarization (GO:0051899)2.64112355
120neuron recognition (GO:0008038)2.63870719
121negative regulation of leukocyte mediated immunity (GO:0002704)2.63763808
122positive regulation of synaptic transmission (GO:0050806)2.60924669
123long term synaptic depression (GO:0060292)2.60864585
124neutrophil activation involved in immune response (GO:0002283)2.59461801
125cellular extravasation (GO:0045123)2.59291645
126regulation of glutamate secretion (GO:0014048)2.59290647
127synaptic vesicle endocytosis (GO:0048488)2.58509406
128regulation of dendritic spine development (GO:0060998)2.57882647
129dendritic spine organization (GO:0097061)2.57801162
130negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56927048
131L-amino acid import (GO:0043092)2.56861765
132dendrite morphogenesis (GO:0048813)2.56692805
133vesicle transport along microtubule (GO:0047496)2.55554884
134neuromuscular process (GO:0050905)2.55509759
135positive regulation of vesicle fusion (GO:0031340)2.53670392
136germinal center formation (GO:0002467)2.52927679
137regulation of mast cell degranulation (GO:0043304)2.48111102
138mannose metabolic process (GO:0006013)2.46478276
139positive regulation of regulated secretory pathway (GO:1903307)2.45586743
140detection of other organism (GO:0098543)2.44725920
141motile cilium assembly (GO:0044458)2.43782759
142microglial cell activation (GO:0001774)2.40827986
143detection of bacterium (GO:0016045)2.39985871
144negative regulation of immunoglobulin mediated immune response (GO:0002890)2.39705719
145negative regulation of B cell mediated immunity (GO:0002713)2.39705719
146membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.38409062
147negative regulation of interleukin-12 production (GO:0032695)2.37979859
148regulation of interferon-beta biosynthetic process (GO:0045357)2.36899806
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.36012388
150myeloid cell activation involved in immune response (GO:0002275)2.35417142
151positive regulation of Rap GTPase activity (GO:0032854)2.33919924
152regulation of leukocyte degranulation (GO:0043300)2.32882329
153regulation of mast cell activation (GO:0033003)2.31692896
154positive regulation of mast cell degranulation (GO:0043306)2.30899049
155positive regulation of mast cell activation involved in immune response (GO:0033008)2.30899049
156B cell receptor signaling pathway (GO:0050853)2.30565890
157interferon-gamma secretion (GO:0072643)2.30542061
158regulation of mast cell activation involved in immune response (GO:0033006)2.29442056
159macrophage activation (GO:0042116)2.29282327
160neutrophil activation (GO:0042119)2.29206234
161negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26978068
162response to muramyl dipeptide (GO:0032495)2.24767393
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.24064031
164response to host immune response (GO:0052572)2.24064031
165regulation of T-helper 2 cell differentiation (GO:0045628)2.23847135
166peptidyl-tyrosine autophosphorylation (GO:0038083)2.22174682
167regulation of ARF GTPase activity (GO:0032312)2.20890353
168potassium ion import (GO:0010107)2.19222719
169cerebellar granule cell differentiation (GO:0021707)2.18968922
170negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.18719324
171gamma-aminobutyric acid signaling pathway (GO:0007214)2.18110539
172positive regulation of CREB transcription factor activity (GO:0032793)2.17320778
173actin filament polymerization (GO:0030041)2.17186408
174T cell selection (GO:0045058)2.15500211
175negative thymic T cell selection (GO:0045060)2.14547901
176regulation of synapse maturation (GO:0090128)2.13538778
177membrane repolarization during action potential (GO:0086011)2.12238187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67088767
2* RARB_27405468_Chip-Seq_BRAIN_Mouse2.86447570
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76171975
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73733779
5GBX2_23144817_ChIP-Seq_PC3_Human2.60950697
6DROSHA_22980978_ChIP-Seq_HELA_Human2.55872739
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53742856
8REST_21632747_ChIP-Seq_MESCs_Mouse2.50280515
9* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44485793
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42232657
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42232657
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41597087
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37775736
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32571603
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28985108
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16269445
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15923052
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15114666
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13398198
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.13027828
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.12572270
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10029574
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05333580
24VDR_21846776_ChIP-Seq_THP-1_Human2.03181202
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.00935738
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93716600
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89680844
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.88041716
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.81891000
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.79568108
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75538226
32* KDM2B_26808549_Chip-Seq_DND41_Human1.72778474
33SPI1_23127762_ChIP-Seq_K562_Human1.68239597
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.67073830
35P68_20966046_ChIP-Seq_HELA_Human1.66941073
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62652569
37VDR_24763502_ChIP-Seq_THP-1_Human1.62393577
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.62361330
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59674967
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55971281
41AR_21572438_ChIP-Seq_LNCaP_Human1.55834817
42RUNX_20019798_ChIP-Seq_JUKART_Human1.55826760
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52388615
44GATA1_19941826_ChIP-Seq_K562_Human1.51196110
45BCOR_27268052_Chip-Seq_Bcells_Human1.49167531
46TCF7_22412390_ChIP-Seq_EML_Mouse1.48900886
47BCL6_27268052_Chip-Seq_Bcells_Human1.48389972
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47105168
49KDM2B_26808549_Chip-Seq_K562_Human1.44210191
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.43989108
51SCL_19346495_ChIP-Seq_HPC-7_Human1.42905558
52* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42645436
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41617470
54* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37733779
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35358462
56MAF_26560356_Chip-Seq_TH1_Human1.34426607
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34351319
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32955635
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31674365
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30902075
61SMAD4_21799915_ChIP-Seq_A2780_Human1.27886660
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27285826
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.26507018
64OCT4_19829295_ChIP-Seq_ESCs_Human1.26291414
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.25896892
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25757051
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25569795
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24723213
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.24500738
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.23834219
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23699016
72* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22399489
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22274399
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21954142
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21087168
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20950484
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20875287
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19704600
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.19426822
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19426198
81RACK7_27058665_Chip-Seq_MCF-7_Human1.19343205
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19175584
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18464628
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.17636525
85AR_19668381_ChIP-Seq_PC3_Human1.17598706
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17257856
87E2F1_20622854_ChIP-Seq_HELA_Human1.16692240
88* UTX_26944678_Chip-Seq_JUKART_Human1.15974966
89CTCF_27219007_Chip-Seq_Bcells_Human1.15854906
90SA1_27219007_Chip-Seq_Bcells_Human1.15742370
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.15244121
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14279892
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12855141
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12664138
95MAF_26560356_Chip-Seq_TH2_Human1.12214896
96GATA2_19941826_ChIP-Seq_K562_Human1.12080213
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11582671
98* RXR_22158963_ChIP-Seq_LIVER_Mouse1.11494140
99MYC_22102868_ChIP-Seq_BL_Human1.10491783
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.09940238
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09656106
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09606423
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09099933
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07815087
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07154658
106PHF8_20622854_ChIP-Seq_HELA_Human1.06805527
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06548949
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05481096
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.05234344
110VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05069492
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04701221
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04272990
113* CTCF_20526341_ChIP-Seq_ESCs_Human1.03543392
114LXR_22158963_ChIP-Seq_LIVER_Mouse1.03337431
115TP63_22573176_ChIP-Seq_HFKS_Human1.02833641
116* ELK3_25401928_ChIP-Seq_HUVEC_Human1.02799644
117STAT3_23295773_ChIP-Seq_U87_Human1.02757595
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01237081
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01155786
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.00939984
121STAT1_20625510_ChIP-Seq_HELA_Human1.00781039
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00559365
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00208955
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99262978
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99009346
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98928599
127ZNF274_21170338_ChIP-Seq_K562_Hela0.98693793
128ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97718884
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.96263481
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.96169529
131STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95779242
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95492214
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95339008
134AHR_22903824_ChIP-Seq_MCF-7_Human0.94810199
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.94620691
136LXR_22292898_ChIP-Seq_THP-1_Human0.94590458
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94325371
138TAF15_26573619_Chip-Seq_HEK293_Human0.94214994
139* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93773773
140FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93161984
141AR_25329375_ChIP-Seq_VCAP_Human0.92452214
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91167017
143* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90951892
144VDR_24787735_ChIP-Seq_THP-1_Human0.90889158
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.90141320
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.88843836
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88452482
148KLF4_19829295_ChIP-Seq_ESCs_Human0.88273895
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88262236
150RXR_22108803_ChIP-Seq_LS180_Human0.87930570
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.85791967
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85654562
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85230409
154SMC4_20622854_ChIP-Seq_HELA_Human0.84469792
155P300_19829295_ChIP-Seq_ESCs_Human0.84304253
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83594060
157TCF4_23295773_ChIP-Seq_U87_Human0.82492221
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81899529
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81536864
160BCAT_22108803_ChIP-Seq_LS180_Human0.81157632
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80911982
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.78996211
163SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78318137
164CREB1_26743006_Chip-Seq_LNCaP_Human0.78245028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.04754269
2MP0002822_catalepsy4.48871285
3MP0003880_abnormal_central_pattern3.74077042
4MP0003635_abnormal_synaptic_transmissio3.71694921
5MP0004270_analgesia3.46983846
6MP0009745_abnormal_behavioral_response3.14076416
7MP0002063_abnormal_learning/memory/cond3.00413398
8MP0003436_decreased_susceptibility_to2.91158582
9MP0002064_seizures2.86032580
10MP0005551_abnormal_eye_electrophysiolog2.82557309
11MP0005423_abnormal_somatic_nervous2.55786769
12MP0009046_muscle_twitch2.45228287
13MP0002572_abnormal_emotion/affect_behav2.41911637
14MP0003724_increased_susceptibility_to2.40452927
15MP0001968_abnormal_touch/_nociception2.31097821
16MP0003303_peritoneal_inflammation2.28705690
17MP0001486_abnormal_startle_reflex2.27942120
18MP0002272_abnormal_nervous_system2.25194144
19MP0005360_urolithiasis2.14921893
20MP0002734_abnormal_mechanical_nocicepti2.12513136
21MP0003183_abnormal_peptide_metabolism2.10566986
22MP0001501_abnormal_sleep_pattern2.08729671
23MP0009780_abnormal_chondrocyte_physiolo2.07023234
24MP0002909_abnormal_adrenal_gland2.04726845
25MP0003329_amyloid_beta_deposits2.00421180
26MP0003011_delayed_dark_adaptation1.91422421
27MP0001790_abnormal_immune_system1.84411387
28MP0005387_immune_system_phenotype1.84411387
29MP0001835_abnormal_antigen_presentation1.84240270
30MP0002653_abnormal_ependyma_morphology1.79662457
31MP0002139_abnormal_hepatobiliary_system1.79034268
32MP0001440_abnormal_grooming_behavior1.72863804
33MP0005000_abnormal_immune_tolerance1.70394507
34MP0005025_abnormal_response_to1.69709089
35MP0002419_abnormal_innate_immunity1.69552551
36MP0005671_abnormal_response_to1.66860775
37MP0002733_abnormal_thermal_nociception1.63476305
38MP0001800_abnormal_humoral_immune1.63251315
39MP0004885_abnormal_endolymph1.62758253
40MP0005310_abnormal_salivary_gland1.62626932
41MP0000685_abnormal_immune_system1.60745808
42MP0005085_abnormal_gallbladder_physiolo1.60215674
43MP0001970_abnormal_pain_threshold1.59235286
44MP0002736_abnormal_nociception_after1.59195848
45MP0006082_CNS_inflammation1.58549107
46MP0001986_abnormal_taste_sensitivity1.56571226
47MP0005253_abnormal_eye_physiology1.55085821
48MP0002735_abnormal_chemical_nociception1.53958617
49MP0003866_abnormal_defecation1.52482087
50MP0002723_abnormal_immune_serum1.51651792
51MP0004924_abnormal_behavior1.51477492
52MP0005386_behavior/neurological_phenoty1.51477492
53MP0002067_abnormal_sensory_capabilities1.51065876
54MP0004858_abnormal_nervous_system1.50874436
55MP0002090_abnormal_vision1.50437872
56MP0008569_lethality_at_weaning1.50388836
57MP0003879_abnormal_hair_cell1.49996639
58MP0002229_neurodegeneration1.48136376
59MP0001984_abnormal_olfaction1.47367548
60MP0005058_abnormal_lysosome_morphology1.46934045
61MP0010155_abnormal_intestine_physiology1.45281042
62MP0006072_abnormal_retinal_apoptosis1.43951340
63MP0004811_abnormal_neuron_physiology1.42190363
64MP0002420_abnormal_adaptive_immunity1.42131678
65MP0001819_abnormal_immune_cell1.41595845
66MP0001502_abnormal_circadian_rhythm1.40081546
67MP0005646_abnormal_pituitary_gland1.39575796
68MP0002557_abnormal_social/conspecific_i1.39102974
69MP0005365_abnormal_bile_salt1.36915585
70MP0002452_abnormal_antigen_presenting1.36727503
71MP0004043_abnormal_pH_regulation1.36470069
72MP0008260_abnormal_autophagy1.35666265
73MP0003633_abnormal_nervous_system1.35171465
74MP0008961_abnormal_basal_metabolism1.35069780
75MP0001348_abnormal_lacrimal_gland1.34365794
76MP0003075_altered_response_to1.33384061
77MP0002882_abnormal_neuron_morphology1.33124029
78MP0008875_abnormal_xenobiotic_pharmacok1.31654823
79MP0001533_abnormal_skeleton_physiology1.25497832
80MP0009785_altered_susceptibility_to1.25325449
81MP0004147_increased_porphyrin_level1.21501335
82MP0002066_abnormal_motor_capabilities/c1.21289304
83MP0001873_stomach_inflammation1.21120233
84MP0005535_abnormal_body_temperature1.19740270
85MP0003283_abnormal_digestive_organ1.18772393
86MP0001529_abnormal_vocalization1.18335754
87MP0005464_abnormal_platelet_physiology1.18159187
88MP0002184_abnormal_innervation1.17378157
89MP0000604_amyloidosis1.16866461
90MP0000955_abnormal_spinal_cord1.16525302
91MP0003045_fibrosis1.16455091
92MP0002148_abnormal_hypersensitivity_rea1.14670658
93MP0004947_skin_inflammation1.12505467
94MP0010329_abnormal_lipoprotein_level1.12259051
95MP0000678_abnormal_parathyroid_gland1.11796255
96MP0003690_abnormal_glial_cell1.08835660
97MP0004381_abnormal_hair_follicle1.08165803
98MP0000778_abnormal_nervous_system1.07663605
99MP0005083_abnormal_biliary_tract1.06589235
100MP0003787_abnormal_imprinting1.05772503
101MP0001845_abnormal_inflammatory_respons1.05071282
102MP0003631_nervous_system_phenotype1.03857541
103MP0008874_decreased_physiological_sensi1.03281497
104MP0010234_abnormal_vibrissa_follicle1.01759222
105MP0008872_abnormal_physiological_respon1.01419165
106MP0002069_abnormal_eating/drinking_beha1.00853087
107MP0003656_abnormal_erythrocyte_physiolo1.00384227
108MP0003763_abnormal_thymus_physiology0.98971406
109MP0001664_abnormal_digestion0.98426169
110MP0000716_abnormal_immune_system0.98073805
111MP0005167_abnormal_blood-brain_barrier0.96843831
112MP0005195_abnormal_posterior_eye0.96383981
113MP0004742_abnormal_vestibular_system0.96131180
114MP0003252_abnormal_bile_duct0.95687748
115MP0000015_abnormal_ear_pigmentation0.95589897
116MP0001663_abnormal_digestive_system0.95152352
117MP0004510_myositis0.94604324
118MP0004142_abnormal_muscle_tone0.93483611
119MP0001905_abnormal_dopamine_level0.92359585
120MP0000013_abnormal_adipose_tissue0.91202053
121MP0006276_abnormal_autonomic_nervous0.91019648
122MP0002277_abnormal_respiratory_mucosa0.90790805
123MP0001177_atelectasis0.90379427
124MP0005166_decreased_susceptibility_to0.89503483
125MP0002132_abnormal_respiratory_system0.87867638
126MP0002398_abnormal_bone_marrow0.87804022
127MP0004019_abnormal_vitamin_homeostasis0.85972325
128MP0004085_abnormal_heartbeat0.85301921
129MP0003634_abnormal_glial_cell0.85038217
130MP0009278_abnormal_bone_marrow0.84014105
131MP0009764_decreased_sensitivity_to0.83380465
132MP0005451_abnormal_body_composition0.82890167
133MP0001765_abnormal_ion_homeostasis0.82399258
134MP0001666_abnormal_nutrient_absorption0.82250058
135MP0009333_abnormal_splenocyte_physiolog0.82124496
136MP0002152_abnormal_brain_morphology0.80457054
137MP0000920_abnormal_myelination0.80324600
138MP0002752_abnormal_somatic_nervous0.79809467
139MP0003195_calcinosis0.78740706
140MP0002638_abnormal_pupillary_reflex0.75813834
141MP0005332_abnormal_amino_acid0.75355827
142MP0002118_abnormal_lipid_homeostasis0.74960362
143MP0002876_abnormal_thyroid_physiology0.74168674
144MP0004130_abnormal_muscle_cell0.70244757
145MP0009840_abnormal_foam_cell0.69955334
146MP0003172_abnormal_lysosome_physiology0.69944792
147MP0010386_abnormal_urinary_bladder0.69226423
148MP0002078_abnormal_glucose_homeostasis0.68763267
149MP0000751_myopathy0.68319513
150MP0005645_abnormal_hypothalamus_physiol0.68154849
151MP0005448_abnormal_energy_balance0.66598326
152MP0001324_abnormal_eye_pigmentation0.66019354
153MP0005584_abnormal_enzyme/coenzyme_acti0.65836792
154MP0003632_abnormal_nervous_system0.64206317
155MP0002837_dystrophic_cardiac_calcinosis0.64090176

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.19845567
2Focal motor seizures (HP:0011153)5.85244123
3Focal seizures (HP:0007359)4.55349368
4Visual hallucinations (HP:0002367)4.46723199
5Congenital stationary night blindness (HP:0007642)4.46037317
6Central scotoma (HP:0000603)4.14958952
7Eczematoid dermatitis (HP:0000976)3.88031504
8Recurrent bacterial skin infections (HP:0005406)3.78072234
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.75198632
10Absent/shortened dynein arms (HP:0200106)3.75198632
11Bony spicule pigmentary retinopathy (HP:0007737)3.67832423
12Epileptic encephalopathy (HP:0200134)3.60798388
13Recurrent abscess formation (HP:0002722)3.59909360
14Pigmentary retinal degeneration (HP:0001146)3.55588158
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.53363939
16Abnormality of macular pigmentation (HP:0008002)3.43077570
17Abnormality of binocular vision (HP:0011514)3.39396999
18Diplopia (HP:0000651)3.39396999
19Nasal polyposis (HP:0100582)3.30829613
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.30358919
21Supranuclear gaze palsy (HP:0000605)3.29723353
22Abnormal respiratory motile cilium morphology (HP:0005938)3.24231216
23Abnormal respiratory epithelium morphology (HP:0012253)3.24231216
24Absence seizures (HP:0002121)3.21567952
25Action tremor (HP:0002345)3.21292183
26Abnormal rod and cone electroretinograms (HP:0008323)3.20951220
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.20060789
28Generalized tonic-clonic seizures (HP:0002069)3.18273991
29Scotoma (HP:0000575)3.17113301
30Progressive cerebellar ataxia (HP:0002073)3.12110602
31Elevated erythrocyte sedimentation rate (HP:0003565)3.10142377
32Myositis (HP:0100614)3.09708395
33Febrile seizures (HP:0002373)3.05165379
34Increased cerebral lipofuscin (HP:0011813)3.04553290
35Abnormal respiratory motile cilium physiology (HP:0012261)3.03986338
36Atonic seizures (HP:0010819)3.02204634
37Dyschromatopsia (HP:0007641)3.00487502
38Dysdiadochokinesis (HP:0002075)2.99773300
39Abnormal ciliary motility (HP:0012262)2.98720910
40Abnormality of macrophages (HP:0004311)2.97688776
41Dialeptic seizures (HP:0011146)2.96140499
42Impaired social interactions (HP:0000735)2.96069626
43Abnormal social behavior (HP:0012433)2.96069626
44Depression (HP:0000716)2.95908571
45Postural instability (HP:0002172)2.93630072
46Torticollis (HP:0000473)2.92596723
47Abnormality of the lower motor neuron (HP:0002366)2.92368474
48Stomatitis (HP:0010280)2.90132417
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.89969634
50Poor eye contact (HP:0000817)2.89791555
51Abnormality of the nasal mucosa (HP:0000433)2.85486991
52Orchitis (HP:0100796)2.82770025
53Anxiety (HP:0000739)2.82757981
54Impaired vibration sensation in the lower limbs (HP:0002166)2.80464730
55Chorioretinal atrophy (HP:0000533)2.80343120
56Obstructive sleep apnea (HP:0002870)2.80099058
57Ankle clonus (HP:0011448)2.77836928
58Dysmetria (HP:0001310)2.77181271
59Agitation (HP:0000713)2.76094618
60Optic neuritis (HP:0100653)2.72315270
61Retrobulbar optic neuritis (HP:0100654)2.72315270
62Abolished electroretinogram (ERG) (HP:0000550)2.70646405
63Urinary bladder sphincter dysfunction (HP:0002839)2.68475813
64Focal dystonia (HP:0004373)2.62193944
65Neurofibrillary tangles (HP:0002185)2.57042768
66Broad-based gait (HP:0002136)2.56737654
67Hyperventilation (HP:0002883)2.56065377
68Truncal ataxia (HP:0002078)2.55192452
69Status epilepticus (HP:0002133)2.54612997
70Cerebral inclusion bodies (HP:0100314)2.54295365
71Craniofacial dystonia (HP:0012179)2.49481666
72Decreased central vision (HP:0007663)2.49174003
73Intention tremor (HP:0002080)2.48480811
74Abnormal eating behavior (HP:0100738)2.47359399
75Recurrent fungal infections (HP:0002841)2.44796905
76Gaze-evoked nystagmus (HP:0000640)2.43702755
77Bronchiectasis (HP:0002110)2.42392625
78Mediastinal lymphadenopathy (HP:0100721)2.40502142
79Recurrent skin infections (HP:0001581)2.39482122
80Mutism (HP:0002300)2.37162214
81Pustule (HP:0200039)2.36450838
82Recurrent gram-negative bacterial infections (HP:0005420)2.33163164
83Genetic anticipation (HP:0003743)2.33059431
84Increased circulating renin level (HP:0000848)2.32783826
85Decreased circulating renin level (HP:0003351)2.32388103
86Amblyopia (HP:0000646)2.32232824
87Spastic gait (HP:0002064)2.31936799
88Ventricular fibrillation (HP:0001663)2.31193500
89Chronic obstructive pulmonary disease (HP:0006510)2.29765700
90Obstructive lung disease (HP:0006536)2.29765700
91Retinal atrophy (HP:0001105)2.29644473
92Urinary urgency (HP:0000012)2.29573602
93Rhinitis (HP:0012384)2.28541853
94Gastrointestinal infarctions (HP:0005244)2.28083598
95Bradykinesia (HP:0002067)2.24033754
96Type II diabetes mellitus (HP:0005978)2.23302421
97Dysostosis multiplex (HP:0000943)2.22911923
98Recurrent sinusitis (HP:0011108)2.22117226
99Hemiplegia (HP:0002301)2.21989221
100Papilledema (HP:0001085)2.19814635
101Dysmetric saccades (HP:0000641)2.19492743
102Choroideremia (HP:0001139)2.17164685
103Abnormality of glycolipid metabolism (HP:0010969)2.16516973
104Abnormality of liposaccharide metabolism (HP:0010968)2.16516973
105Abnormality of glycosphingolipid metabolism (HP:0004343)2.16516973
106Scanning speech (HP:0002168)2.16430433
107Epileptiform EEG discharges (HP:0011182)2.15955448
108Macular degeneration (HP:0000608)2.15644465
109Posterior subcapsular cataract (HP:0007787)2.14871505
110Impaired smooth pursuit (HP:0007772)2.11499492
111Gout (HP:0001997)2.10487825
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09948099
113EEG with generalized epileptiform discharges (HP:0011198)2.08394405
114Generalized myoclonic seizures (HP:0002123)2.07415332
115Slow saccadic eye movements (HP:0000514)2.06877044
116Resting tremor (HP:0002322)2.06555654
117Gingivitis (HP:0000230)2.05080433
118Annular pancreas (HP:0001734)2.05006685
119Hypochromic anemia (HP:0001931)2.04256893
120Chronic mucocutaneous candidiasis (HP:0002728)2.03725828
121Recurrent cutaneous fungal infections (HP:0011370)2.03725828
122Vasculitis (HP:0002633)2.03075958
123Impaired vibratory sensation (HP:0002495)2.02710585
124Stereotypic behavior (HP:0000733)2.02371279
125Drooling (HP:0002307)2.01545657
126Excessive salivation (HP:0003781)2.01545657
127Hypsarrhythmia (HP:0002521)2.01109765
128Abnormal delayed hypersensitivity skin test (HP:0002963)2.00484585
129Prolonged bleeding time (HP:0003010)1.97988853
130Photophobia (HP:0000613)1.93644661
131Pendular nystagmus (HP:0012043)1.91645161
132Encephalitis (HP:0002383)1.91009651
133Megalencephaly (HP:0001355)1.89837671
134Insomnia (HP:0100785)1.88483806
135Deep venous thrombosis (HP:0002625)1.87564359
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87233117
137Abnormality of ocular smooth pursuit (HP:0000617)1.86271891
138Clumsiness (HP:0002312)1.86139467
139Meningitis (HP:0001287)1.85910079
140Hemiparesis (HP:0001269)1.85270457
141Hyperthyroidism (HP:0000836)1.84568766
142Insidious onset (HP:0003587)1.84452022
143Termporal pattern (HP:0011008)1.84452022
144Attenuation of retinal blood vessels (HP:0007843)1.83923850
145Chronic otitis media (HP:0000389)1.83628063
146Lower limb muscle weakness (HP:0007340)1.82845710
147Recurrent otitis media (HP:0000403)1.82797990
148Clonus (HP:0002169)1.82735962
149Rigidity (HP:0002063)1.82649215
150Spontaneous hematomas (HP:0007420)1.81995208
151Absent speech (HP:0001344)1.81852168
152Neuronal loss in central nervous system (HP:0002529)1.81442066
153Pheochromocytoma (HP:0002666)1.81138032
154Hemoptysis (HP:0002105)1.80138853
155Episodic fever (HP:0001954)1.80138626
156Abnormality of polysaccharide metabolism (HP:0011012)1.79666799
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79666799
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79666799
159Global brain atrophy (HP:0002283)1.79315408
160Increased IgE level (HP:0003212)1.79305707
161Abnormality of the corticospinal tract (HP:0002492)1.78892663
162Memory impairment (HP:0002354)1.78538455
163Blue irides (HP:0000635)1.78494827
164Abnormal EKG (HP:0003115)1.78063907
165Progressive visual loss (HP:0000529)1.77249821
166Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77134838
167Bundle branch block (HP:0011710)1.76635621
168Hypochromic microcytic anemia (HP:0004840)1.76283219
169Ocular albinism (HP:0001107)1.76221280
170Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76192607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.36331613
2NTRK34.23029179
3MAP3K93.60036331
4DAPK22.67202061
5PRKD32.63859160
6KSR22.58501431
7MAP4K12.39376408
8MAP3K42.23567661
9MINK12.20902518
10CAMKK12.09961447
11PAK62.07932717
12MARK11.98680366
13ERN11.94154031
14NTRK11.93230238
15RIPK41.85997464
16MAP3K21.83306030
17MAP3K111.79823814
18GRK61.77142290
19BLK1.72309492
20NTRK21.69615406
21MAP2K41.68402776
22SIK21.62339781
23FES1.57645899
24CDK51.53770573
25KSR11.53748567
26MAP2K31.53730478
27MAP2K71.53508285
28TYK21.52649248
29MAP3K131.45105222
30STK381.41177457
31TAOK11.40600220
32ZAP701.35179214
33ARAF1.33313667
34IRAK41.32327531
35PINK11.32114849
36CSK1.30730099
37GRK51.26257278
38PRKCH1.24532386
39DAPK11.22585765
40SGK4941.14740638
41SGK2231.14740638
42TYRO31.10536180
43PRKCG1.08932033
44PRPF4B1.08860700
45SYK1.07209331
46BMPR21.06341997
47CAMK1D1.05635599
48TNIK1.04030599
49SIK11.03359870
50MAP2K61.01972934
51STK111.00826216
52BTK1.00798807
53MARK20.97914644
54PDPK10.97824495
55MAPK150.97098926
56GRK10.96756693
57MAP3K10.96413221
58UHMK10.96121007
59SGK30.93925715
60EPHB10.92805255
61CAMKK20.91308228
62RET0.91108950
63CAMK2A0.90827686
64JAK20.90140972
65PDK10.89844124
66HCK0.86330123
67CAMK10.86276691
68RPS6KA20.85392258
69SGK20.84957306
70SMG10.84355494
71JAK10.84019895
72INSRR0.82533207
73SGK10.81140382
74MAP3K30.81061889
75PTK2B0.80240022
76PNCK0.79823115
77CAMK2B0.79472323
78ITK0.78711003
79OXSR10.78057241
80PRKCZ0.76059297
81ACVR1B0.74587014
82MAP3K70.73957584
83TXK0.72943844
84WNK40.72726818
85TRIB30.72252197
86ALK0.72057934
87PLK20.71769552
88SIK30.71631620
89HIPK20.71487641
90CDK150.71117151
91CAMK1G0.69847190
92CDK180.69691033
93TBK10.69073212
94IKBKE0.68848494
95PAK30.68694831
96RAF10.68586072
97CDK140.67841272
98MAP3K60.67602160
99RIPK10.67436053
100PTK60.67075755
101IRAK30.66250665
102MAP3K120.63276475
103PHKG20.63242651
104PHKG10.63242651
105ICK0.63030663
106MAPK130.63003685
107LCK0.62153331
108CSNK1G20.61074681
109SCYL20.60828918
110CDC42BPA0.60444632
111CDK11A0.59324906
112RPS6KA30.58510478
113MAP2K20.55710292
114MAP2K10.55173578
115MAPKAPK30.54516138
116PKN20.54306472
117LYN0.53784511
118MATK0.53256880
119LMTK20.53175269
120PRKD20.52887698
121TNK20.52141513
122ERBB20.52006844
123DYRK1A0.51642464
124IRAK10.51432961
125CAMK2D0.50614153
126FYN0.50232174
127WNK30.49328261
128TAOK30.48922475
129RPS6KA60.48553231
130CAMK2G0.47168183
131PRKCQ0.46978465
132FRK0.46970826
133MAPK120.46457657
134IRAK20.45983120
135CAMK40.45766031
136FGFR20.45360390
137WNK10.45302465
138PRKACG0.43799089
139AKT30.43474857
140CDK190.43393157
141FER0.42730552
142MAPK100.41735537
143PRKCB0.40425026
144PRKCE0.39708612

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.67863413
2Synaptic vesicle cycle_Homo sapiens_hsa047212.78520785
3Nicotine addiction_Homo sapiens_hsa050332.63582614
4Olfactory transduction_Homo sapiens_hsa047402.62238914
5Nitrogen metabolism_Homo sapiens_hsa009102.60684376
6GABAergic synapse_Homo sapiens_hsa047272.40452560
7Circadian entrainment_Homo sapiens_hsa047132.22884124
8Glutamatergic synapse_Homo sapiens_hsa047242.11112163
9Morphine addiction_Homo sapiens_hsa050322.10138369
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10132867
11Long-term potentiation_Homo sapiens_hsa047202.10021303
12Amphetamine addiction_Homo sapiens_hsa050312.06537654
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03694389
14Insulin secretion_Homo sapiens_hsa049111.86915255
15Dopaminergic synapse_Homo sapiens_hsa047281.82502765
16Salivary secretion_Homo sapiens_hsa049701.74232244
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73606448
18Cholinergic synapse_Homo sapiens_hsa047251.70094333
19Cocaine addiction_Homo sapiens_hsa050301.69782723
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63102334
21Osteoclast differentiation_Homo sapiens_hsa043801.61202843
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58669457
23Gastric acid secretion_Homo sapiens_hsa049711.55003167
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53332843
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47832430
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46297061
27B cell receptor signaling pathway_Homo sapiens_hsa046621.43776034
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39358606
29Renin secretion_Homo sapiens_hsa049241.38813014
30Arginine biosynthesis_Homo sapiens_hsa002201.34917640
31Bile secretion_Homo sapiens_hsa049761.34847689
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33749540
33Leishmaniasis_Homo sapiens_hsa051401.31197838
34Oxytocin signaling pathway_Homo sapiens_hsa049211.28416655
35Tuberculosis_Homo sapiens_hsa051521.25390072
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.24686113
37T cell receptor signaling pathway_Homo sapiens_hsa046601.21728049
38Taste transduction_Homo sapiens_hsa047421.19779251
39Serotonergic synapse_Homo sapiens_hsa047261.19709558
40Type II diabetes mellitus_Homo sapiens_hsa049301.19284315
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18319020
42Calcium signaling pathway_Homo sapiens_hsa040201.16790138
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16193764
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.15036170
45Chemokine signaling pathway_Homo sapiens_hsa040621.12816549
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12265228
47Long-term depression_Homo sapiens_hsa047301.11001891
48GnRH signaling pathway_Homo sapiens_hsa049121.10467799
49cAMP signaling pathway_Homo sapiens_hsa040241.06292440
50Collecting duct acid secretion_Homo sapiens_hsa049661.06062887
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01695036
52Butanoate metabolism_Homo sapiens_hsa006500.99922622
53Acute myeloid leukemia_Homo sapiens_hsa052210.99651552
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96417519
55Gap junction_Homo sapiens_hsa045400.95282392
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95038715
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93996625
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92681506
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91379797
60Staphylococcus aureus infection_Homo sapiens_hsa051500.91024171
61Other glycan degradation_Homo sapiens_hsa005110.90555489
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.87950995
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87832586
64Glioma_Homo sapiens_hsa052140.86419829
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86151988
66Estrogen signaling pathway_Homo sapiens_hsa049150.84420783
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84222357
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.82815136
69Thyroid hormone synthesis_Homo sapiens_hsa049180.82382014
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80434327
71Allograft rejection_Homo sapiens_hsa053300.79779838
72Prolactin signaling pathway_Homo sapiens_hsa049170.79739831
73Pancreatic secretion_Homo sapiens_hsa049720.79125102
74Graft-versus-host disease_Homo sapiens_hsa053320.77210484
75Lysosome_Homo sapiens_hsa041420.76719876
76Hepatitis C_Homo sapiens_hsa051600.73891639
77TNF signaling pathway_Homo sapiens_hsa046680.73230768
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72874602
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.72098558
80Dorso-ventral axis formation_Homo sapiens_hsa043200.67872182
81African trypanosomiasis_Homo sapiens_hsa051430.67648546
82Melanogenesis_Homo sapiens_hsa049160.66687458
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.66013409
84Platelet activation_Homo sapiens_hsa046110.65383395
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65106962
86ErbB signaling pathway_Homo sapiens_hsa040120.63577587
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63530672
88Histidine metabolism_Homo sapiens_hsa003400.63035229
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62640387
90Phagosome_Homo sapiens_hsa041450.61914988
91Type I diabetes mellitus_Homo sapiens_hsa049400.61759550
92Vibrio cholerae infection_Homo sapiens_hsa051100.61705009
93Autoimmune thyroid disease_Homo sapiens_hsa053200.61536953
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61526313
95Glucagon signaling pathway_Homo sapiens_hsa049220.59688047
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.58963778
97Linoleic acid metabolism_Homo sapiens_hsa005910.58280270
98Primary immunodeficiency_Homo sapiens_hsa053400.58203190
99Axon guidance_Homo sapiens_hsa043600.57843656
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57103755
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.56970589
102Glycerolipid metabolism_Homo sapiens_hsa005610.54775437
103Choline metabolism in cancer_Homo sapiens_hsa052310.54711995
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53785366
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53049184
106Prion diseases_Homo sapiens_hsa050200.52278654
107Cardiac muscle contraction_Homo sapiens_hsa042600.51455348
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.50764843
109Circadian rhythm_Homo sapiens_hsa047100.50026169
110ABC transporters_Homo sapiens_hsa020100.47832090
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45956267
112PPAR signaling pathway_Homo sapiens_hsa033200.45603824
113Fat digestion and absorption_Homo sapiens_hsa049750.45350572
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45284173
115Tryptophan metabolism_Homo sapiens_hsa003800.45118505
116Inositol phosphate metabolism_Homo sapiens_hsa005620.44680968
117mTOR signaling pathway_Homo sapiens_hsa041500.44566755
118VEGF signaling pathway_Homo sapiens_hsa043700.43373487
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43340402
120Dilated cardiomyopathy_Homo sapiens_hsa054140.41889663
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41776247
122Mineral absorption_Homo sapiens_hsa049780.40714763
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38373898
124MAPK signaling pathway_Homo sapiens_hsa040100.37664776
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35136449
126Non-small cell lung cancer_Homo sapiens_hsa052230.34820728
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34729375
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33284784
129Insulin signaling pathway_Homo sapiens_hsa049100.32881761
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31686304
131Rap1 signaling pathway_Homo sapiens_hsa040150.31631532
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.30454773
133Endocytosis_Homo sapiens_hsa041440.29780727
134Oocyte meiosis_Homo sapiens_hsa041140.29138190
135Ras signaling pathway_Homo sapiens_hsa040140.28998836
136Insulin resistance_Homo sapiens_hsa049310.26469491
137Ovarian steroidogenesis_Homo sapiens_hsa049130.25637748
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.25576412
139Starch and sucrose metabolism_Homo sapiens_hsa005000.25435281

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