C2CD4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)7.10964270
2COPII vesicle coating (GO:0048208)6.99163263
3regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.85157025
4protein maturation by protein folding (GO:0022417)6.80714544
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.62641921
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.54811504
7signal peptide processing (GO:0006465)6.48002406
8endocrine pancreas development (GO:0031018)6.43950073
9positive regulation of nuclease activity (GO:0032075)6.40798167
10regulation of nuclease activity (GO:0032069)5.81262380
11sequestering of metal ion (GO:0051238)5.77731922
12regulation of type B pancreatic cell apoptotic process (GO:2000674)5.76504813
13endoplasmic reticulum unfolded protein response (GO:0030968)5.65399062
14ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.59309855
15peptide hormone processing (GO:0016486)5.52813758
16glandular epithelial cell differentiation (GO:0002067)5.49357342
17cellular response to unfolded protein (GO:0034620)5.47725645
18cellular response to topologically incorrect protein (GO:0035967)5.29481083
19vesicle coating (GO:0006901)5.22857843
20ER-nucleus signaling pathway (GO:0006984)5.15195294
21GDP-mannose metabolic process (GO:0019673)4.83988051
22response to endoplasmic reticulum stress (GO:0034976)4.71877896
23ER overload response (GO:0006983)4.61493926
24signal transduction involved in regulation of gene expression (GO:0023019)4.58794083
25positive regulation of insulin secretion (GO:0032024)4.50900842
26negative regulation of norepinephrine secretion (GO:0010700)4.36816005
27protein N-linked glycosylation via asparagine (GO:0018279)4.33523374
28peptidyl-asparagine modification (GO:0018196)4.29237612
29negative regulation of glycoprotein biosynthetic process (GO:0010561)4.23994409
30response to unfolded protein (GO:0006986)4.17418609
31negative regulation of catecholamine secretion (GO:0033604)4.15066624
32ER to Golgi vesicle-mediated transport (GO:0006888)4.09687543
33maintenance of protein localization in organelle (GO:0072595)4.06103871
34response to topologically incorrect protein (GO:0035966)4.04550109
35cellular zinc ion homeostasis (GO:0006882)3.98718797
36protein N-linked glycosylation (GO:0006487)3.98079748
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.97520461
38cellular ketone body metabolic process (GO:0046950)3.95836967
39nucleoside diphosphate catabolic process (GO:0009134)3.90582774
40regulation of insulin secretion (GO:0050796)3.89953502
41proline biosynthetic process (GO:0006561)3.87947841
42axoneme assembly (GO:0035082)3.83515840
43protein autoprocessing (GO:0016540)3.65407891
44water-soluble vitamin biosynthetic process (GO:0042364)3.62866280
45respiratory chain complex IV assembly (GO:0008535)3.62038760
46positive regulation of peptide hormone secretion (GO:0090277)3.61580624
47inositol phosphate catabolic process (GO:0071545)3.57623028
48ketone body metabolic process (GO:1902224)3.55350734
49cell redox homeostasis (GO:0045454)3.55087250
50cytochrome complex assembly (GO:0017004)3.54517688
51positive regulation of glycolytic process (GO:0045821)3.53557199
52regulation of peptide hormone secretion (GO:0090276)3.53522261
533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.52639035
54purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.52639035
55adenosine receptor signaling pathway (GO:0001973)3.52632569
56negative regulation of insulin secretion (GO:0046676)3.51411746
57regulation of memory T cell differentiation (GO:0043380)3.50877899
58maintenance of gastrointestinal epithelium (GO:0030277)3.49908750
59positive regulation of peptide secretion (GO:0002793)3.49829379
604-hydroxyproline metabolic process (GO:0019471)3.48453157
61regulation of peptide secretion (GO:0002791)3.46819915
62regulation of glucokinase activity (GO:0033131)3.46073328
63regulation of hexokinase activity (GO:1903299)3.46073328
64glycerophospholipid catabolic process (GO:0046475)3.44765312
65phosphorylated carbohydrate dephosphorylation (GO:0046838)3.40557684
66inositol phosphate dephosphorylation (GO:0046855)3.40557684
67indole-containing compound catabolic process (GO:0042436)3.38051077
68indolalkylamine catabolic process (GO:0046218)3.38051077
69tryptophan catabolic process (GO:0006569)3.38051077
70interferon-gamma secretion (GO:0072643)3.32865309
71insulin secretion (GO:0030073)3.32669362
72zinc ion transport (GO:0006829)3.29144163
73glandular epithelial cell development (GO:0002068)3.25016269
74response to hexose (GO:0009746)3.24653294
75intestinal epithelial cell development (GO:0060576)3.23976564
76prostate gland growth (GO:0060736)3.22916653
77polyol catabolic process (GO:0046174)3.22317443
78negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.21973519
79Golgi organization (GO:0007030)3.18769883
80columnar/cuboidal epithelial cell development (GO:0002066)3.17667172
81folic acid-containing compound biosynthetic process (GO:0009396)3.16548178
82response to glucose (GO:0009749)3.16185651
83L-fucose catabolic process (GO:0042355)3.15326519
84fucose catabolic process (GO:0019317)3.15326519
85L-fucose metabolic process (GO:0042354)3.15326519
86negative regulation of glycoprotein metabolic process (GO:1903019)3.13681215
87response to pheromone (GO:0019236)3.12275109
88auditory receptor cell differentiation (GO:0042491)3.12212603
89regulation of autophagic vacuole assembly (GO:2000785)3.11614753
90indolalkylamine metabolic process (GO:0006586)3.09750895
91intra-Golgi vesicle-mediated transport (GO:0006891)3.09006205
92response to monosaccharide (GO:0034284)3.08531199
93negative regulation of execution phase of apoptosis (GO:1900118)3.07737900
94regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.07206288
95maternal placenta development (GO:0001893)3.06863645
96regulation of hormone secretion (GO:0046883)3.05585220
97epithelial cell maturation (GO:0002070)3.05006962
98positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.03038940
99kidney morphogenesis (GO:0060993)2.99688261
100negative regulation of peptide hormone secretion (GO:0090278)2.99648636
101toxin metabolic process (GO:0009404)2.97109252
102epithelial structure maintenance (GO:0010669)2.96322992
103adaptation of signaling pathway (GO:0023058)2.95284391
104Golgi vesicle transport (GO:0048193)2.94821047
105positive regulation of hormone secretion (GO:0046887)2.93885228
106basic amino acid transport (GO:0015802)2.93649268
107peptidyl-proline hydroxylation (GO:0019511)2.93079047
108epithelial cell fate commitment (GO:0072148)2.91154475
109type B pancreatic cell development (GO:0003323)2.90915725
110positive regulation of meiosis (GO:0045836)2.90748563
111peptide biosynthetic process (GO:0043043)2.90575943
112pyrimidine-containing compound transmembrane transport (GO:0072531)2.89997939
113astrocyte differentiation (GO:0048708)2.88942776
114platelet dense granule organization (GO:0060155)2.88811775
115regulation of calcium ion-dependent exocytosis (GO:0017158)2.87659196
116negative regulation of peptide secretion (GO:0002792)2.86932965
117positive regulation of calcium ion import (GO:0090280)2.84729521
118positive regulation of gluconeogenesis (GO:0045722)2.84289283
119behavioral response to nicotine (GO:0035095)2.83946989
120protein localization to Golgi apparatus (GO:0034067)2.83803720
121polarized epithelial cell differentiation (GO:0030859)2.83431898
122cellular response to hexose stimulus (GO:0071331)2.82574130
123pteridine-containing compound biosynthetic process (GO:0042559)2.82202357
124regulation of peptide transport (GO:0090087)2.80513358
125regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.80234613
126regulation of neurotransmitter uptake (GO:0051580)2.78888128
127preassembly of GPI anchor in ER membrane (GO:0016254)2.78579738
128peptide metabolic process (GO:0006518)2.77732629
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.77471838
130growth hormone secretion (GO:0030252)2.77425591
131protein complex biogenesis (GO:0070271)2.77335538
132digestion (GO:0007586)2.76647710
133DNA deamination (GO:0045006)2.76374138
134cornea development in camera-type eye (GO:0061303)2.75135461
135nitric oxide mediated signal transduction (GO:0007263)2.74726122
136positive regulation of p38MAPK cascade (GO:1900745)2.74288822
137aromatic amino acid family catabolic process (GO:0009074)2.74251742
138regulation of oxidative phosphorylation (GO:0002082)2.73720971
139tryptophan metabolic process (GO:0006568)2.73429270
140positive regulation of meiotic cell cycle (GO:0051446)2.71437791
141inositol phosphate-mediated signaling (GO:0048016)2.70496271
142nitric oxide biosynthetic process (GO:0006809)2.69957426
143regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.63719098
144alanine transport (GO:0032328)2.63293210
145kynurenine metabolic process (GO:0070189)2.62316687
146nephron epithelium morphogenesis (GO:0072088)2.62115513
147nephron tubule morphogenesis (GO:0072078)2.62115513
148regulation of acrosome reaction (GO:0060046)2.61858543
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60693364
150macroautophagy (GO:0016236)2.58664612
151magnesium ion transport (GO:0015693)2.57876165
152intestinal cholesterol absorption (GO:0030299)2.56784477
153detection of light stimulus involved in visual perception (GO:0050908)2.56168325
154detection of light stimulus involved in sensory perception (GO:0050962)2.56168325
155protein localization to cilium (GO:0061512)2.55803744
156epithelial cilium movement (GO:0003351)2.52896591
157embryonic epithelial tube formation (GO:0001838)2.50540908
158regulation of action potential (GO:0098900)2.50249740
159establishment of protein localization to Golgi (GO:0072600)2.48750498
160indole-containing compound metabolic process (GO:0042430)2.47431419
161piRNA metabolic process (GO:0034587)2.46966351
162amine catabolic process (GO:0009310)2.44422535
163cellular biogenic amine catabolic process (GO:0042402)2.44422535
164auditory receptor cell stereocilium organization (GO:0060088)2.43427027
165cilium morphogenesis (GO:0060271)2.43264880
166UDP-N-acetylglucosamine metabolic process (GO:0006047)2.42880701
167dopamine transport (GO:0015872)2.42760917
168mannosylation (GO:0097502)2.41398648
169negative regulation of complement activation (GO:0045916)2.40855434
170C4-dicarboxylate transport (GO:0015740)2.40774078
171regulation of glycolytic process (GO:0006110)2.40659341
172S-adenosylmethionine metabolic process (GO:0046500)2.40350480
173parturition (GO:0007567)2.39504451
174photoreceptor cell maintenance (GO:0045494)2.39154620
175keratinocyte development (GO:0003334)2.39145401
176negative regulation of neurological system process (GO:0031645)2.38750615
177mitochondrial respiratory chain complex assembly (GO:0033108)2.38507893
178protein targeting to Golgi (GO:0000042)2.37956214
179negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.37815811
180positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.35412724
181zinc ion homeostasis (GO:0055069)2.34572522
182renal tubule morphogenesis (GO:0061333)2.33717338
183lactate metabolic process (GO:0006089)2.32598151
184nephron tubule formation (GO:0072079)2.31989190
185Golgi transport vesicle coating (GO:0048200)12.2534390
186COPI coating of Golgi vesicle (GO:0048205)12.2534390
187maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.9067741
188protein retention in ER lumen (GO:0006621)10.0498482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.83174891
2PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.72762042
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.65001569
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.33759596
5ZNF274_21170338_ChIP-Seq_K562_Hela3.07205468
6GBX2_23144817_ChIP-Seq_PC3_Human3.04575901
7GATA1_22025678_ChIP-Seq_K562_Human2.75554558
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61803196
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58072112
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.54560598
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.50149505
12CLOCK_20551151_ChIP-Seq_293T_Human2.44710578
13ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.34476961
14VDR_22108803_ChIP-Seq_LS180_Human2.28533466
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05748187
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04693468
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03961959
18P300_19829295_ChIP-Seq_ESCs_Human1.98628059
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92131323
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90648017
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88847405
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.87196480
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82967333
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79876872
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77936484
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77324665
27BCAT_22108803_ChIP-Seq_LS180_Human1.76754542
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74260630
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73074030
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.72895937
31FUS_26573619_Chip-Seq_HEK293_Human1.71133920
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70760235
33ER_23166858_ChIP-Seq_MCF-7_Human1.70314368
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69406647
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.66109492
36GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.65577989
37LXR_22292898_ChIP-Seq_THP-1_Human1.65553496
38SMAD4_21799915_ChIP-Seq_A2780_Human1.61392159
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60956413
40IGF1R_20145208_ChIP-Seq_DFB_Human1.60459079
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60384696
42GATA4_25053715_ChIP-Seq_YYC3_Human1.57985226
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57706278
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.56565048
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55164106
46EWS_26573619_Chip-Seq_HEK293_Human1.55036188
47TAF15_26573619_Chip-Seq_HEK293_Human1.53718197
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.52628955
49STAT3_23295773_ChIP-Seq_U87_Human1.52043275
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51267503
51CHD1_26751641_Chip-Seq_LNCaP_Human1.50306501
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.48799730
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48630228
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48449501
55AR_25329375_ChIP-Seq_VCAP_Human1.47183393
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46370598
57CBP_20019798_ChIP-Seq_JUKART_Human1.45857807
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45857807
59* TP53_22573176_ChIP-Seq_HFKS_Human1.44750655
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43905851
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43204884
62TCF4_22108803_ChIP-Seq_LS180_Human1.43001848
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.42363996
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.41669848
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41566526
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41500205
67GATA6_25053715_ChIP-Seq_YYC3_Human1.41296783
68RACK7_27058665_Chip-Seq_MCF-7_Human1.41249799
69TCF4_23295773_ChIP-Seq_U87_Human1.41130766
70TFEB_21752829_ChIP-Seq_HELA_Human1.40839083
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40690100
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40086382
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37830461
74CDX2_22108803_ChIP-Seq_LS180_Human1.37292340
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37047519
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35625587
77SOX2_20726797_ChIP-Seq_SW620_Human1.34814077
78GATA1_19941826_ChIP-Seq_K562_Human1.33258348
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33111842
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33018867
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.32929586
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32485355
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31920721
84ATF3_27146783_Chip-Seq_COLON_Human1.31663182
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31635896
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31070128
87* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30755533
88CREB1_26743006_Chip-Seq_LNCaP_Human1.29662461
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.29390613
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29292566
91* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28872988
92MYC_22102868_ChIP-Seq_BL_Human1.28797329
93* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.28086412
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.28025722
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28025722
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27858759
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27622684
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27570509
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26563267
100P53_22387025_ChIP-Seq_ESCs_Mouse1.26225138
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.25692471
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25461618
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24397927
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.24076146
105HTT_18923047_ChIP-ChIP_STHdh_Human1.23333409
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23243929
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22610609
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22050824
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21975757
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21829030
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21679205
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21550427
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.21163917
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20673402
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20527803
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20345158
117SOX2_19829295_ChIP-Seq_ESCs_Human1.19808290
118NANOG_19829295_ChIP-Seq_ESCs_Human1.19808290
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.19691013
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19224924
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.18905661
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18154954
123CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18151324
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17909850
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17849869
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17062721
127RUNX2_22187159_ChIP-Seq_PCA_Human1.16353329
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16017417
129ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15526816
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.15406636
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.15337982
132E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15256760
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15130003
134LXR_22158963_ChIP-Seq_LIVER_Mouse1.15117447
135ERG_21242973_ChIP-ChIP_JURKAT_Human1.13945065
136AR_20517297_ChIP-Seq_VCAP_Human1.13854767
137SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12597046
138ARNT_22903824_ChIP-Seq_MCF-7_Human1.10459057
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10053354
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10048069
141* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09477800
142TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09477298
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.09179402
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08824569
145P300_18555785_Chip-Seq_ESCs_Mouse1.08129037
146GABP_19822575_ChIP-Seq_HepG2_Human1.07424299
147EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06696153
148GATA3_24758297_ChIP-Seq_MCF-7_Human1.06529128
149HOXB7_26014856_ChIP-Seq_BT474_Human1.06420086
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06083037
151SOX2_18555785_Chip-Seq_ESCs_Mouse1.05971341
152REST_19997604_ChIP-ChIP_NEURONS_Mouse1.05398012
153NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05239848
154SOX17_20123909_ChIP-Seq_XEN_Mouse1.04957558
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04729208
156FOXA1_25552417_ChIP-Seq_VCAP_Human1.03786456
157SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03738835
158NCOR_22424771_ChIP-Seq_293T_Human1.03409969
159NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03194301
160STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03170475
161SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03127581
162NMYC_18555785_Chip-Seq_ESCs_Mouse1.02723623
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02473793
164TET1_21451524_ChIP-Seq_MESCs_Mouse1.02103128
165IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01200513
166CTCF_20526341_ChIP-Seq_ESCs_Human1.00739691
167DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00654508
168SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00532181
169JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00288586
170* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00158547
171RUNX1_27514584_Chip-Seq_MCF-7_Human0.99917394
172TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99657716
173TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99608788
174ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98982313
175TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98829141
176GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97884387
177GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97853476
178YY1_22570637_ChIP-Seq_MALME-3M_Human0.97852112
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.97708777
180SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97176104
181SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97005987
182GATA3_21878914_ChIP-Seq_MCF-7_Human0.96594792
183HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96368204
184CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96075710
185RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95373718
186BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93465676
187ERG_20517297_ChIP-Seq_VCAP_Human0.92258194
188KDM5A_27292631_Chip-Seq_BREAST_Human0.91308320
189PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90543553
190TET1_21490601_ChIP-Seq_MESCs_Mouse0.89609472
191TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89023935
192SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88469961
193CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87106056
194XRN2_22483619_ChIP-Seq_HELA_Human0.87051745
195CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85919806
196TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85146837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.36902554
2MP0002877_abnormal_melanocyte_morpholog4.70979918
3MP0009780_abnormal_chondrocyte_physiolo4.35290500
4MP0004043_abnormal_pH_regulation4.24874231
5MP0002693_abnormal_pancreas_physiology3.99727476
6MP0005220_abnormal_exocrine_pancreas3.90232793
7MP0001944_abnormal_pancreas_morphology3.70570417
8MP0002909_abnormal_adrenal_gland3.32396071
9MP0000013_abnormal_adipose_tissue3.29646677
10MP0000372_irregular_coat_pigmentation3.06952632
11MP0002254_reproductive_system_inflammat2.90727691
12MP0002163_abnormal_gland_morphology2.88942290
13MP0000462_abnormal_digestive_system2.85920833
14MP0003195_calcinosis2.79851553
15MP0002876_abnormal_thyroid_physiology2.71030207
16MP0004264_abnormal_extraembryonic_tissu2.64766851
17MP0010386_abnormal_urinary_bladder2.59749591
18MP0001666_abnormal_nutrient_absorption2.58844459
19MP0008877_abnormal_DNA_methylation2.47347441
20MP0010234_abnormal_vibrissa_follicle2.44956958
21MP0005310_abnormal_salivary_gland2.20246749
22MP0005646_abnormal_pituitary_gland2.17515840
23MP0002078_abnormal_glucose_homeostasis2.14017147
24MP0002928_abnormal_bile_duct2.13843508
25MP0008875_abnormal_xenobiotic_pharmacok2.05538504
26MP0000003_abnormal_adipose_tissue2.00895700
27MP0009643_abnormal_urine_homeostasis1.95616881
28MP0006072_abnormal_retinal_apoptosis1.93732457
29MP0005365_abnormal_bile_salt1.93635594
30MP0000678_abnormal_parathyroid_gland1.91908856
31MP0003119_abnormal_digestive_system1.91511576
32MP0001765_abnormal_ion_homeostasis1.85496778
33MP0003183_abnormal_peptide_metabolism1.84416077
34MP0005551_abnormal_eye_electrophysiolog1.83208708
35MP0009046_muscle_twitch1.83136023
36MP0002938_white_spotting1.82425095
37MP0002837_dystrophic_cardiac_calcinosis1.80360113
38MP0005084_abnormal_gallbladder_morpholo1.78075928
39MP0008004_abnormal_stomach_pH1.74650131
40MP0003300_gastrointestinal_ulcer1.73105348
41MP0003122_maternal_imprinting1.70096866
42MP0008872_abnormal_physiological_respon1.66930480
43MP0000569_abnormal_digit_pigmentation1.66102479
44MP0001664_abnormal_digestion1.64725361
45MP0005379_endocrine/exocrine_gland_phen1.62331873
46MP0005636_abnormal_mineral_homeostasis1.61172096
47MP0006054_spinal_hemorrhage1.57601558
48MP0005253_abnormal_eye_physiology1.57334412
49MP0005332_abnormal_amino_acid1.55642373
50MP0005174_abnormal_tail_pigmentation1.54869438
51MP0005083_abnormal_biliary_tract1.53975947
52MP0003866_abnormal_defecation1.53728712
53MP0002896_abnormal_bone_mineralization1.53120066
54MP0010329_abnormal_lipoprotein_level1.52502001
55MP0009672_abnormal_birth_weight1.52285844
56MP0003123_paternal_imprinting1.51351085
57MP0002102_abnormal_ear_morphology1.44421519
58MP0001501_abnormal_sleep_pattern1.44323347
59MP0000427_abnormal_hair_cycle1.38979814
60MP0001756_abnormal_urination1.38722229
61MP0002234_abnormal_pharynx_morphology1.37197977
62MP0002277_abnormal_respiratory_mucosa1.32202918
63MP0004147_increased_porphyrin_level1.32082008
64MP0001968_abnormal_touch/_nociception1.29370483
65MP0000383_abnormal_hair_follicle1.28753840
66MP0010678_abnormal_skin_adnexa1.28597647
67MP0003953_abnormal_hormone_level1.27848195
68MP0009745_abnormal_behavioral_response1.27708256
69MP0002139_abnormal_hepatobiliary_system1.20931711
70MP0000613_abnormal_salivary_gland1.20866734
71MP0003693_abnormal_embryo_hatching1.20854961
72MP0002160_abnormal_reproductive_system1.20032240
73MP0002638_abnormal_pupillary_reflex1.16671712
74MP0004133_heterotaxia1.16521136
75MP0003136_yellow_coat_color1.16270126
76MP0009703_decreased_birth_body1.07480796
77MP0002272_abnormal_nervous_system1.06743929
78MP0001270_distended_abdomen1.06724687
79MP0004233_abnormal_muscle_weight1.05378557
80MP0005367_renal/urinary_system_phenotyp1.01350551
81MP0000516_abnormal_urinary_system1.01350551
82MP0004272_abnormal_basement_membrane1.01340861
83MP0000470_abnormal_stomach_morphology1.00381956
84MP0005076_abnormal_cell_differentiation0.98090960
85MP0002269_muscular_atrophy0.97465741
86MP0004885_abnormal_endolymph0.97457077
87MP0003959_abnormal_lean_body0.95083969
88MP0005085_abnormal_gallbladder_physiolo0.94661554
89MP0004215_abnormal_myocardial_fiber0.94118773
90MP0002970_abnormal_white_adipose0.93087825
91MP0003045_fibrosis0.90233589
92MP0001348_abnormal_lacrimal_gland0.89225540
93MP0005075_abnormal_melanosome_morpholog0.89205042
94MP0002557_abnormal_social/conspecific_i0.89061090
95MP0001502_abnormal_circadian_rhythm0.88518199
96MP0003011_delayed_dark_adaptation0.88370102
97MP0001984_abnormal_olfaction0.86211784
98MP0005058_abnormal_lysosome_morphology0.86074032
99MP0002736_abnormal_nociception_after0.85985752
100MP0005257_abnormal_intraocular_pressure0.85917607
101MP0001764_abnormal_homeostasis0.85900506
102MP0000631_abnormal_neuroendocrine_gland0.85450327
103MP0000538_abnormal_urinary_bladder0.85324825
104MP0008961_abnormal_basal_metabolism0.84822581
105MP0002168_other_aberrant_phenotype0.84553307
106MP0004019_abnormal_vitamin_homeostasis0.81187664
107MP0002229_neurodegeneration0.81025601
108MP0002095_abnormal_skin_pigmentation0.80531638
109MP0004142_abnormal_muscle_tone0.80378017
110MP0001485_abnormal_pinna_reflex0.80312155
111MP0005381_digestive/alimentary_phenotyp0.79727701
112MP0003890_abnormal_embryonic-extraembry0.79722169
113MP0002090_abnormal_vision0.79435829
114MP0005375_adipose_tissue_phenotype0.79093480
115MP0005645_abnormal_hypothalamus_physiol0.77630126
116MP0002064_seizures0.77392774
117MP0005408_hypopigmentation0.77356980
118MP0005448_abnormal_energy_balance0.76381457
119MP0000015_abnormal_ear_pigmentation0.76262711
120MP0001970_abnormal_pain_threshold0.74838976
121MP0003633_abnormal_nervous_system0.74687765
122MP0003638_abnormal_response/metabolism_0.74683032
123MP0003787_abnormal_imprinting0.74672016
124MP0003795_abnormal_bone_structure0.73986709
125MP0006036_abnormal_mitochondrial_physio0.73181143
126MP0002118_abnormal_lipid_homeostasis0.72335122
127MP0002098_abnormal_vibrissa_morphology0.71460596
128MP0003938_abnormal_ear_development0.69537915
129MP0004957_abnormal_blastocyst_morpholog0.69374490
130MP0003252_abnormal_bile_duct0.69147600
131MP0004924_abnormal_behavior0.68548926
132MP0005386_behavior/neurological_phenoty0.68548926
133MP0005334_abnormal_fat_pad0.67614689
134MP0006292_abnormal_olfactory_placode0.66578226
135MP0000647_abnormal_sebaceous_gland0.66550970
136MP0005452_abnormal_adipose_tissue0.64327419
137MP0002138_abnormal_hepatobiliary_system0.63637564
138MP0001849_ear_inflammation0.63428460
139MP0003656_abnormal_erythrocyte_physiolo0.60702573
140MP0009642_abnormal_blood_homeostasis0.60004681
141MP0003879_abnormal_hair_cell0.58043238
142MP0005187_abnormal_penis_morphology0.57385436
143MP0000230_abnormal_systemic_arterial0.56631408
144MP0005535_abnormal_body_temperature0.54280767
145MP0000639_abnormal_adrenal_gland0.52680346
146MP0002971_abnormal_brown_adipose0.52405864
147MP0004270_analgesia0.50365610
148MP0003943_abnormal_hepatobiliary_system0.50005546
149MP0000163_abnormal_cartilage_morphology0.49547700
150MP0001661_extended_life_span0.47620017
151MP0000609_abnormal_liver_physiology0.47509892
152MP0003942_abnormal_urinary_system0.46391976
153MP0005389_reproductive_system_phenotype0.46191722
154MP0003868_abnormal_feces_composition0.45902212
155MP0003566_abnormal_cell_adhesion0.45885064
156MP0004858_abnormal_nervous_system0.45785406
157MP0001919_abnormal_reproductive_system0.44106685
158MP0001727_abnormal_embryo_implantation0.44087472

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.17597870
2Hypoglycemic seizures (HP:0002173)7.47063334
3Hypoglycemic coma (HP:0001325)7.20606526
4Symptomatic seizures (HP:0011145)6.42895735
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.27040590
6Hyperglycemia (HP:0003074)5.09808566
7Ketoacidosis (HP:0001993)4.95979281
8Abnormality of the pancreatic islet cells (HP:0006476)4.79796125
9Abnormality of endocrine pancreas physiology (HP:0012093)4.79796125
10Insulin-resistant diabetes mellitus (HP:0000831)4.52534739
11Abnormal pancreas size (HP:0012094)4.39525426
12Thoracolumbar scoliosis (HP:0002944)4.33584268
13Late onset (HP:0003584)4.13397091
14Hypothermia (HP:0002045)4.11943136
15Abnormality of calcium-phosphate metabolism (HP:0100530)3.93346333
16Pancreatic islet-cell hyperplasia (HP:0004510)3.93291764
17Agitation (HP:0000713)3.82697473
18Abnormality of the renal cortex (HP:0011035)3.81212630
19Gout (HP:0001997)3.63042803
20Congenital stationary night blindness (HP:0007642)3.59587516
21Large for gestational age (HP:0001520)3.46100240
22Pancreatic cysts (HP:0001737)3.46000450
23Abnormality of small intestinal villus morphology (HP:0011472)3.44976472
24Villous atrophy (HP:0011473)3.44976472
25Hyperparathyroidism (HP:0000843)3.44236348
26Insulin resistance (HP:0000855)3.43706538
27Decreased circulating renin level (HP:0003351)3.42315429
28Pancreatic fibrosis (HP:0100732)3.39155662
29Mucopolysacchariduria (HP:0008155)3.36476092
30Urinary glycosaminoglycan excretion (HP:0003541)3.36476092
31Retinal atrophy (HP:0001105)3.31365577
32Molar tooth sign on MRI (HP:0002419)3.27126437
33Abnormality of midbrain morphology (HP:0002418)3.27126437
34Polydipsia (HP:0001959)3.20824657
35Abnormal drinking behavior (HP:0030082)3.20824657
36Generalized aminoaciduria (HP:0002909)3.18737499
37Exocrine pancreatic insufficiency (HP:0001738)3.17640486
38Nephronophthisis (HP:0000090)3.12413085
39Renal cortical cysts (HP:0000803)3.12398027
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12299276
41Abnormality of polysaccharide metabolism (HP:0011012)3.12299276
42Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12299276
43Hypomagnesemia (HP:0002917)3.03717607
44Ketosis (HP:0001946)3.02660724
45Abnormality of the renal medulla (HP:0100957)3.02224281
46Gaze-evoked nystagmus (HP:0000640)2.98840611
47Type II lissencephaly (HP:0007260)2.92481117
48Abnormality of the intrinsic pathway (HP:0010989)2.91175487
49Abnormal rod and cone electroretinograms (HP:0008323)2.90669909
50Hyperactive renin-angiotensin system (HP:0000841)2.84907410
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.84755020
52True hermaphroditism (HP:0010459)2.81482979
53Testicular neoplasm (HP:0010788)2.79627441
54Hyperventilation (HP:0002883)2.79483801
55Hypercortisolism (HP:0001578)2.78350932
56Chronic bronchitis (HP:0004469)2.76191134
57Dysostosis multiplex (HP:0000943)2.75280606
58Albinism (HP:0001022)2.75131140
59Abnormality of vitamin B metabolism (HP:0004340)2.74195719
60Attenuation of retinal blood vessels (HP:0007843)2.72348106
61Congenital sensorineural hearing impairment (HP:0008527)2.66729582
62Tubular atrophy (HP:0000092)2.65666413
63Polyuria (HP:0000103)2.57857005
64Medial flaring of the eyebrow (HP:0010747)2.57617727
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55722838
66Abnormal protein N-linked glycosylation (HP:0012347)2.55722838
67Abnormal protein glycosylation (HP:0012346)2.55722838
68Abnormal glycosylation (HP:0012345)2.55722838
69Abdominal distention (HP:0003270)2.55626141
70Methylmalonic acidemia (HP:0002912)2.52836485
71Osteomalacia (HP:0002749)2.52767443
72Hemiparesis (HP:0001269)2.47460508
73Aplasia/hypoplasia of the uterus (HP:0008684)2.43132635
74Growth hormone excess (HP:0000845)2.40112166
75Restlessness (HP:0000711)2.39350625
76Hypokalemia (HP:0002900)2.38397647
77Pheochromocytoma (HP:0002666)2.32656628
78Progressive macrocephaly (HP:0004481)2.31900016
79Dysautonomia (HP:0002459)2.30043570
80Type I transferrin isoform profile (HP:0003642)2.25162862
81Methylmalonic aciduria (HP:0012120)2.18601771
82Abnormal albumin level (HP:0012116)2.18112181
83Hypoalbuminemia (HP:0003073)2.18112181
84Reticulocytosis (HP:0001923)2.17945598
85Menstrual irregularities (HP:0000858)2.17749132
86Vacuolated lymphocytes (HP:0001922)2.16980788
87Abnormality of renal excretion (HP:0011036)2.16270896
88Abnormality of magnesium homeostasis (HP:0004921)2.14904468
89Glycosuria (HP:0003076)2.14698292
90Abnormality of urine glucose concentration (HP:0011016)2.14698292
91Progressive inability to walk (HP:0002505)2.14018699
92Type I diabetes mellitus (HP:0100651)2.13724345
93EEG with generalized epileptiform discharges (HP:0011198)2.13433051
94Acute necrotizing encephalopathy (HP:0006965)2.12266815
95Hypsarrhythmia (HP:0002521)2.09819982
96Generalized hyperpigmentation (HP:0007440)2.09733489
97Primary adrenal insufficiency (HP:0008207)2.08740511
98Prominent metopic ridge (HP:0005487)2.08563087
99Hyperphosphatemia (HP:0002905)2.07348381
100Abnormality of macular pigmentation (HP:0008002)2.06933705
101Keratoconus (HP:0000563)2.06096846
102Increased corneal curvature (HP:0100692)2.06096846
103Abnormal urine output (HP:0012590)2.05010942
104Gastrointestinal atresia (HP:0002589)2.03886899
105Cystic liver disease (HP:0006706)2.03376959
106Progressive neurologic deterioration (HP:0002344)2.03347530
107Abnormality of vitamin metabolism (HP:0100508)2.03316436
108Congenital glaucoma (HP:0001087)2.03116353
109Mitochondrial inheritance (HP:0001427)2.03004679
110Abolished electroretinogram (ERG) (HP:0000550)2.02138406
111Decreased subcutaneous fat (HP:0001002)2.01770565
112Disproportionate short-trunk short stature (HP:0003521)2.01636240
113Epileptiform EEG discharges (HP:0011182)2.01202908
114Irregular vertebral endplates (HP:0003301)2.00293514
115Adrenal overactivity (HP:0002717)1.99941856
116Short middle phalanx of the 5th finger (HP:0004220)1.99751298
117Increased CSF lactate (HP:0002490)1.97646488
118Metaphyseal dysplasia (HP:0100255)1.96035770
119Chronic hepatic failure (HP:0100626)1.95765153
120Neuroendocrine neoplasm (HP:0100634)1.95624992
121Congenital primary aphakia (HP:0007707)1.93205239
122Cortical visual impairment (HP:0100704)1.92818070
1233-Methylglutaconic aciduria (HP:0003535)1.92594926
124Furrowed tongue (HP:0000221)1.92102000
125Glucose intolerance (HP:0000833)1.90628158
126Widely spaced teeth (HP:0000687)1.90460935
127Fair hair (HP:0002286)1.90006635
128Missing ribs (HP:0000921)1.89573221
129Protuberant abdomen (HP:0001538)1.88821019
130Hypoplasia of the fovea (HP:0007750)1.88797069
131Aplasia/Hypoplasia of the fovea (HP:0008060)1.88797069
132Acute encephalopathy (HP:0006846)1.88165619
133Abnormality of chloride homeostasis (HP:0011422)1.88141737
134Polycythemia (HP:0001901)1.88024980
135Gait imbalance (HP:0002141)1.87511225
136Tetany (HP:0001281)1.87449169
137Vascular calcification (HP:0004934)1.87274611
138Abnormality of glycolipid metabolism (HP:0010969)1.86750353
139Abnormality of liposaccharide metabolism (HP:0010968)1.86750353
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.86750353
141Abnormality of the distal phalanges of the toes (HP:0010182)1.86685765
142Stomach cancer (HP:0012126)1.86042976
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85845537
144Amelogenesis imperfecta (HP:0000705)1.85419104
145Pendular nystagmus (HP:0012043)1.84972191
146Hyperkalemia (HP:0002153)1.84853810
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.83854757
148Inability to walk (HP:0002540)1.82289865
149Hypoproteinemia (HP:0003075)1.82094561
150Hypokalemic alkalosis (HP:0001949)1.82079458
151Broad-based gait (HP:0002136)1.81718209
152Abnormality of purine metabolism (HP:0004352)1.80785326
153Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80760045
154Tinnitus (HP:0000360)1.80393607
155Intestinal atresia (HP:0011100)1.79745552
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79447240
157Thyroid-stimulating hormone excess (HP:0002925)1.78149811
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.77873358
159Abnormality of renin-angiotensin system (HP:0000847)1.77774561
160Hepatic necrosis (HP:0002605)1.76549422
161Tachypnea (HP:0002789)1.76435728
162Lipid accumulation in hepatocytes (HP:0006561)1.75903237
163Genital tract atresia (HP:0001827)1.74612463
164Neoplasm of the adrenal cortex (HP:0100641)1.73256990
165Hypoplasia of the pons (HP:0012110)1.72773321
166Enlarged penis (HP:0000040)1.72570624
167Abnormality of alkaline phosphatase activity (HP:0004379)1.71829392
168Hypoplasia of the uterus (HP:0000013)1.71712082
169Nephrogenic diabetes insipidus (HP:0009806)1.71652714
170Abnormality of the pons (HP:0007361)1.71007933
171Increased hepatocellular lipid droplets (HP:0006565)1.70242679
172Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.69681340
173Unilateral renal agenesis (HP:0000122)1.69063165
174Abnormality of the vitamin B12 metabolism (HP:0004341)1.68928646
175Tongue fasciculations (HP:0001308)1.68751664
176Decreased central vision (HP:0007663)1.68686503
177Acute hepatic failure (HP:0006554)1.68576236
178Myoglobinuria (HP:0002913)1.68225161
179Stomatitis (HP:0010280)1.67980264
180Abnormality of the fovea (HP:0000493)1.67627842
181Abnormality of the metopic suture (HP:0005556)1.67145814
182Hypotension (HP:0002615)1.67127325
183Abnormal biliary tract morphology (HP:0012440)1.66438302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK6.27536660
2INSRR5.76457440
3MAPK155.74275746
4ERN15.35037607
5MAP4K23.14284187
6GRK12.79262856
7HIPK22.72700952
8ADRBK22.70559121
9SCYL22.32781504
10BCKDK2.32616468
11EPHA22.22343537
12BMPR1B2.21541524
13NUAK12.04661491
14TRIB32.04434244
15FLT32.04208679
16DAPK22.00185183
17PINK11.99338229
18CCNB11.86049004
19WNK41.84559373
20MAP3K41.82051315
21MAP2K21.79337450
22FGFR21.77167614
23NTRK11.73596731
24ACVR1B1.69464860
25PAK31.68469635
26STK391.68165594
27EPHA31.64415931
28ZAK1.59496185
29PRKD31.59394729
30MAP3K21.55915405
31CASK1.51072148
32CSNK1G11.50443072
33DYRK1B1.43369705
34TLK11.42325690
35PHKG11.42232308
36PHKG21.42232308
37STK38L1.40418190
38PTK61.36834642
39PTK21.36209766
40BRSK11.36108592
41PIK3CG1.36025294
42TXK1.35096568
43MET1.30902712
44EIF2AK31.29628394
45TRIM281.26616774
46OXSR11.21439442
47PDGFRA1.19546712
48MAP3K11.17262626
49NME11.16643111
50TESK11.16267309
51ARAF1.16142865
52TAOK31.15050918
53DYRK31.13927954
54UHMK11.09921565
55FER1.09347989
56MAP3K101.09226892
57TRPM71.08390618
58CSNK1G31.05310129
59BRAF1.04844791
60PIK3CA1.03480260
61MAPK131.02648658
62BRSK21.01094066
63EPHB11.01069221
64CSNK1G20.97507119
65MKNK20.96869322
66FGFR40.95522849
67IRAK10.94551948
68MAP3K120.92183168
69MST40.88248856
70NEK10.87160305
71ERBB40.85884923
72MAP2K60.85302340
73ADRBK10.84255151
74STK30.81213685
75PKN20.79848627
76NTRK30.79507603
77PDK20.79410461
78TNIK0.78780860
79PTK2B0.78363289
80IKBKB0.78166732
81PRKCI0.77320316
82TNK20.77117660
83SIK10.74985621
84KSR20.72807282
85TSSK60.70313176
86MAP2K10.69077853
87MAPKAPK30.65120585
88PRKCG0.64901079
89TIE10.64501805
90CSNK1A10.62831426
91SGK20.60064688
92MAP2K70.59891346
93BUB10.59157967
94PRKCH0.57988535
95CDC42BPA0.57644381
96TGFBR10.56459305
97STK240.55073991
98CSNK1A1L0.53666822
99PRKCQ0.52653094
100RET0.52004760
101MAP3K90.51798648
102MTOR0.51722467
103CSK0.50871396
104PRKD10.50805498
105PRKCE0.50364417
106TESK20.50053141
107PRKAA20.49935821
108CAMK2A0.49102316
109BCR0.48899605
110FGFR30.47936635
111ERBB30.47752908
112WNK30.47607805
113PLK20.46922672
114NEK20.46405942
115AKT30.46100100
116MUSK0.44369747
117RPS6KA20.44045543
118PAK20.43747774
119AURKA0.43189971
120PRKACA0.43059527
121RPS6KA50.40549234
122IKBKE0.39748034
123JAK30.39611531
124PNCK0.39508591
125PAK40.38277636
126MST1R0.38090234
127STK160.37917534
128FRK0.36909522
129CAMK2D0.36408848
130RIPK10.35792179
131IGF1R0.35319527
132PIM20.34516866
133MAPKAPK20.33118388
134TEC0.32894575
135PLK30.32251216
136LMTK20.31938192
137CSNK1D0.31709462
138SGK2230.31708795
139SGK4940.31708795
140PRKG10.31469493
141PRKAA10.31409712
142PRKCA0.31151146
143RPS6KB20.30411422
144JAK10.30037040
145MAP3K110.29091143
146DAPK10.28747293
147LATS10.28486054
148JAK20.27962080
149MAPK30.27812825
150VRK10.27801667
151CAMKK20.27258985
152CHUK0.26662566
153STK110.26401623
154MAPK90.25655635
155PRKACB0.25532990
156PRKCZ0.25462281
157ALK0.24370043
158GSK3A0.23613012
159ERBB20.22352502
160PRKD20.21351357
161DYRK20.20457130
162PRKDC0.20249546
163PDPK10.19125211
164LRRK20.17771056
165CAMKK10.17363657
166CAMK2B0.17163181
167RPS6KA10.17062186
168CHEK20.16468512
169ZAP700.16035932
170MAPK140.13335205
171PRKACG0.13126012
172MAPK10.12948964
173CDK50.12631868
174NLK0.12597708

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.46572379
2Protein export_Homo sapiens_hsa030606.52543317
3Sulfur metabolism_Homo sapiens_hsa009204.36082980
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.21179997
5Vibrio cholerae infection_Homo sapiens_hsa051103.07002787
6N-Glycan biosynthesis_Homo sapiens_hsa005102.33879134
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32358158
8Caffeine metabolism_Homo sapiens_hsa002322.30168892
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28388768
10Insulin secretion_Homo sapiens_hsa049112.24317216
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15363671
12Vitamin B6 metabolism_Homo sapiens_hsa007502.12119902
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09744470
14Selenocompound metabolism_Homo sapiens_hsa004502.07339036
15Nitrogen metabolism_Homo sapiens_hsa009101.96407466
16Oxidative phosphorylation_Homo sapiens_hsa001901.88521079
17Phototransduction_Homo sapiens_hsa047441.82798698
18Ether lipid metabolism_Homo sapiens_hsa005651.79877900
19Type II diabetes mellitus_Homo sapiens_hsa049301.68812399
20Pancreatic secretion_Homo sapiens_hsa049721.63780887
21Folate biosynthesis_Homo sapiens_hsa007901.61444998
22Lysosome_Homo sapiens_hsa041421.52703700
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48348639
24Propanoate metabolism_Homo sapiens_hsa006401.47932777
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42929672
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42686181
27Histidine metabolism_Homo sapiens_hsa003401.41094896
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37160431
29Cocaine addiction_Homo sapiens_hsa050301.26755721
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22889981
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21848000
32Thyroid hormone synthesis_Homo sapiens_hsa049181.20759282
33Peroxisome_Homo sapiens_hsa041461.18917336
34Chemical carcinogenesis_Homo sapiens_hsa052041.13735519
35Prion diseases_Homo sapiens_hsa050201.13138709
36Retinol metabolism_Homo sapiens_hsa008301.12786866
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11345820
38Galactose metabolism_Homo sapiens_hsa000521.11296355
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08201565
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.06355405
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05030699
42Ovarian steroidogenesis_Homo sapiens_hsa049131.03748118
43Other glycan degradation_Homo sapiens_hsa005111.03112563
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03106693
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.02208735
46Basal transcription factors_Homo sapiens_hsa030221.02060144
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01258633
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96782546
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96405157
50Arachidonic acid metabolism_Homo sapiens_hsa005900.95609867
51Mineral absorption_Homo sapiens_hsa049780.93723023
52Parkinsons disease_Homo sapiens_hsa050120.93272684
53Tryptophan metabolism_Homo sapiens_hsa003800.92354189
54Type I diabetes mellitus_Homo sapiens_hsa049400.86656590
55Nicotine addiction_Homo sapiens_hsa050330.84820392
56Taste transduction_Homo sapiens_hsa047420.83556930
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81519459
58Arginine and proline metabolism_Homo sapiens_hsa003300.79922999
59Amphetamine addiction_Homo sapiens_hsa050310.76403495
60Collecting duct acid secretion_Homo sapiens_hsa049660.75366148
61Circadian rhythm_Homo sapiens_hsa047100.75350551
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.74295035
63Insulin resistance_Homo sapiens_hsa049310.73882198
64Fat digestion and absorption_Homo sapiens_hsa049750.72326561
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72078830
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71235313
67Starch and sucrose metabolism_Homo sapiens_hsa005000.68583027
68Synaptic vesicle cycle_Homo sapiens_hsa047210.65345383
69Legionellosis_Homo sapiens_hsa051340.64804377
70Glucagon signaling pathway_Homo sapiens_hsa049220.63037874
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62895509
72Regulation of autophagy_Homo sapiens_hsa041400.61329690
73Dorso-ventral axis formation_Homo sapiens_hsa043200.60485834
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58280230
75Antigen processing and presentation_Homo sapiens_hsa046120.57184320
76Estrogen signaling pathway_Homo sapiens_hsa049150.56969391
77Protein digestion and absorption_Homo sapiens_hsa049740.56565648
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54080564
79Glycerolipid metabolism_Homo sapiens_hsa005610.53485097
80beta-Alanine metabolism_Homo sapiens_hsa004100.52996659
81Butanoate metabolism_Homo sapiens_hsa006500.52495292
82Renin secretion_Homo sapiens_hsa049240.52458075
83Prolactin signaling pathway_Homo sapiens_hsa049170.52381658
84Salivary secretion_Homo sapiens_hsa049700.51888977
85Morphine addiction_Homo sapiens_hsa050320.51188029
86Fatty acid metabolism_Homo sapiens_hsa012120.51172877
87Fanconi anemia pathway_Homo sapiens_hsa034600.51128390
88RNA degradation_Homo sapiens_hsa030180.50053881
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49684358
90Lysine degradation_Homo sapiens_hsa003100.49153076
91Glutamatergic synapse_Homo sapiens_hsa047240.48814085
92Bladder cancer_Homo sapiens_hsa052190.48806578
93Phenylalanine metabolism_Homo sapiens_hsa003600.47386802
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46695585
95RNA polymerase_Homo sapiens_hsa030200.46298003
96Fructose and mannose metabolism_Homo sapiens_hsa000510.45961495
97Olfactory transduction_Homo sapiens_hsa047400.43726757
98Alcoholism_Homo sapiens_hsa050340.43268245
99Huntingtons disease_Homo sapiens_hsa050160.43139330
100Purine metabolism_Homo sapiens_hsa002300.43046885
101Cardiac muscle contraction_Homo sapiens_hsa042600.41477492
102Arginine biosynthesis_Homo sapiens_hsa002200.40026965
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38773713
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37836243
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37312518
106Dopaminergic synapse_Homo sapiens_hsa047280.37085157
107ABC transporters_Homo sapiens_hsa020100.36585706
108One carbon pool by folate_Homo sapiens_hsa006700.35750476
109Rheumatoid arthritis_Homo sapiens_hsa053230.35555047
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.34215889
111Long-term potentiation_Homo sapiens_hsa047200.33651849
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33330315
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33200858
114Renin-angiotensin system_Homo sapiens_hsa046140.33064229
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31722343
116Sphingolipid metabolism_Homo sapiens_hsa006000.28460673
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26773966
118Insulin signaling pathway_Homo sapiens_hsa049100.26644967
119GABAergic synapse_Homo sapiens_hsa047270.22312276
120Linoleic acid metabolism_Homo sapiens_hsa005910.21918322
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21704209
122Fatty acid degradation_Homo sapiens_hsa000710.21651770
123Gastric acid secretion_Homo sapiens_hsa049710.20910963
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19582958
125Amoebiasis_Homo sapiens_hsa051460.19513098
126Thyroid cancer_Homo sapiens_hsa052160.18889170
127Circadian entrainment_Homo sapiens_hsa047130.18862086
128Glutathione metabolism_Homo sapiens_hsa004800.17081761
129Phagosome_Homo sapiens_hsa041450.16940146
130Cholinergic synapse_Homo sapiens_hsa047250.16194785
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15909163
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15562402
133Tight junction_Homo sapiens_hsa045300.15004145
134Metabolic pathways_Homo sapiens_hsa011000.14879052
135Serotonergic synapse_Homo sapiens_hsa047260.14375296
136Endocytosis_Homo sapiens_hsa041440.13736613
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13628517
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.12042618
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11798680
140Melanogenesis_Homo sapiens_hsa049160.11538354
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09571859
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08594913
143Prostate cancer_Homo sapiens_hsa052150.07874718
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.06988602
145Renal cell carcinoma_Homo sapiens_hsa052110.06677613
146AMPK signaling pathway_Homo sapiens_hsa041520.06072451
147Fatty acid elongation_Homo sapiens_hsa000620.06003842
148p53 signaling pathway_Homo sapiens_hsa041150.05457299
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.04635882
150Alzheimers disease_Homo sapiens_hsa050100.03879904

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