C2CD4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.68437741
2COPI coating of Golgi vesicle (GO:0048205)8.68437741
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.51667714
4exocrine pancreas development (GO:0031017)8.35611756
5protein retention in ER lumen (GO:0006621)7.97516029
6endocrine pancreas development (GO:0031018)6.70972078
7protein maturation by protein folding (GO:0022417)6.34468688
8intestinal cholesterol absorption (GO:0030299)6.02589846
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.32277096
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.29207032
11COPII vesicle coating (GO:0048208)5.25500923
12digestion (GO:0007586)5.21286764
13glandular epithelial cell differentiation (GO:0002067)5.20850315
14positive regulation of nuclease activity (GO:0032075)5.05009555
15peptide hormone processing (GO:0016486)4.72652381
16regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.72027732
17regulation of nuclease activity (GO:0032069)4.58640352
18endoplasmic reticulum unfolded protein response (GO:0030968)4.54717597
19cellular response to unfolded protein (GO:0034620)4.48093756
20lymphangiogenesis (GO:0001946)4.45796943
21regulation of type B pancreatic cell apoptotic process (GO:2000674)4.45625354
22type B pancreatic cell development (GO:0003323)4.42602797
23cellular response to topologically incorrect protein (GO:0035967)4.30461289
24blood vessel maturation (GO:0001955)4.24338970
25ER overload response (GO:0006983)4.23175844
26ER-nucleus signaling pathway (GO:0006984)4.23029137
27signal peptide processing (GO:0006465)4.17577245
28glandular epithelial cell development (GO:0002068)4.11168839
29inner ear receptor cell development (GO:0060119)4.10645369
30insulin secretion (GO:0030073)4.10300657
31cellular ketone body metabolic process (GO:0046950)4.09133073
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.06054689
33positive regulation of insulin secretion (GO:0032024)4.05293833
34regulation of secondary heart field cardioblast proliferation (GO:0003266)4.03938200
35regulation of cardioblast proliferation (GO:0003264)4.03938200
36intestinal absorption (GO:0050892)3.96612552
37embryonic heart tube development (GO:0035050)3.95749009
38response to endoplasmic reticulum stress (GO:0034976)3.89533933
39pancreas development (GO:0031016)3.87742674
40sequestering of metal ion (GO:0051238)3.86904949
41vesicle coating (GO:0006901)3.82277771
42intestinal epithelial cell development (GO:0060576)3.79592914
43columnar/cuboidal epithelial cell development (GO:0002066)3.78407522
44glycerophospholipid catabolic process (GO:0046475)3.75651466
45positive regulation of gluconeogenesis (GO:0045722)3.73740774
46positive regulation of calcium ion import (GO:0090280)3.70832640
47dendritic spine morphogenesis (GO:0060997)3.68619398
48regulation of insulin secretion (GO:0050796)3.67706094
49nephron tubule morphogenesis (GO:0072078)3.62592412
50nephron epithelium morphogenesis (GO:0072088)3.62592412
51response to unfolded protein (GO:0006986)3.61968513
52left/right pattern formation (GO:0060972)3.58395443
53ketone body metabolic process (GO:1902224)3.56994176
54response to topologically incorrect protein (GO:0035966)3.49099797
55proline biosynthetic process (GO:0006561)3.45114240
56inositol phosphate catabolic process (GO:0071545)3.43860740
57mRNA transcription from RNA polymerase II promoter (GO:0042789)3.43710587
58auditory receptor cell differentiation (GO:0042491)3.42748222
59maintenance of protein localization in organelle (GO:0072595)3.41048959
60morphogenesis of an endothelium (GO:0003159)3.37132344
61endothelial tube morphogenesis (GO:0061154)3.37132344
62protein localization to Golgi apparatus (GO:0034067)3.36216588
63negative regulation of inclusion body assembly (GO:0090084)3.35153698
64regulation of peptide hormone secretion (GO:0090276)3.33311737
65L-ascorbic acid metabolic process (GO:0019852)3.33250153
66inositol phosphate dephosphorylation (GO:0046855)3.32928368
67phosphorylated carbohydrate dephosphorylation (GO:0046838)3.32928368
68negative regulation of norepinephrine secretion (GO:0010700)3.31811884
69L-alpha-amino acid transmembrane transport (GO:1902475)3.31721306
70glycolipid catabolic process (GO:0019377)3.30223640
71nucleoside diphosphate catabolic process (GO:0009134)3.29828752
72regulation of peptide secretion (GO:0002791)3.27651870
73regulation of calcium ion-dependent exocytosis (GO:0017158)3.27330791
74negative regulation of execution phase of apoptosis (GO:1900118)3.26058140
75protein N-linked glycosylation via asparagine (GO:0018279)3.25604213
76peptidyl-asparagine modification (GO:0018196)3.25396067
77kidney morphogenesis (GO:0060993)3.23151196
78cerebellar Purkinje cell layer development (GO:0021680)3.21544431
79negative regulation of protein autophosphorylation (GO:0031953)3.21501058
80endothelium development (GO:0003158)3.21455348
81protein localization to cilium (GO:0061512)3.20812825
82negative regulation of insulin secretion (GO:0046676)3.19979429
83positive regulation of peptide hormone secretion (GO:0090277)3.19780677
84renal tubule morphogenesis (GO:0061333)3.19501503
85potassium ion export (GO:0071435)3.19297165
86negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17281408
87negative regulation of catecholamine secretion (GO:0033604)3.17252701
88epithelial cell fate commitment (GO:0072148)3.15683671
89GDP-mannose metabolic process (GO:0019673)3.13875902
90negative regulation of digestive system process (GO:0060457)3.12002586
91regulation of calcium ion import (GO:0090279)3.11892688
92intra-Golgi vesicle-mediated transport (GO:0006891)3.11508638
93mitotic cell cycle arrest (GO:0071850)3.11506346
94negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.11309173
95astrocyte differentiation (GO:0048708)3.11197171
96positive regulation of peptide secretion (GO:0002793)3.09964111
97positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.06489961
98heme transport (GO:0015886)3.06253133
99transcytosis (GO:0045056)3.01772443
100peptide hormone secretion (GO:0030072)3.01694102
101positive regulation of glomerulus development (GO:0090193)2.99583699
102pharyngeal system development (GO:0060037)2.99496471
103detection of calcium ion (GO:0005513)2.99084476
104negative regulation of blood vessel endothelial cell migration (GO:0043537)2.98238534
105endothelial cell chemotaxis (GO:0035767)2.98152727
106protein N-linked glycosylation (GO:0006487)2.97920438
107regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97636655
108regulation of endothelial cell differentiation (GO:0045601)2.97208044
109neuron fate determination (GO:0048664)2.95347727
110cellular response to hepatocyte growth factor stimulus (GO:0035729)2.95275567
111response to hepatocyte growth factor (GO:0035728)2.95275567
112mRNA transcription (GO:0009299)2.95032296
113ceramide catabolic process (GO:0046514)2.94698301
114peptide secretion (GO:0002790)2.93908248
115response to hexose (GO:0009746)2.92963500
116intraciliary transport (GO:0042073)2.86885135
117negative regulation of activin receptor signaling pathway (GO:0032926)2.86477369
118polyol catabolic process (GO:0046174)2.86248674
119regulation of hormone secretion (GO:0046883)2.85737459
120response to glucose (GO:0009749)2.84925058
121water-soluble vitamin biosynthetic process (GO:0042364)2.84745223
122nitric oxide mediated signal transduction (GO:0007263)2.84043737
123chemosensory behavior (GO:0007635)2.83092779
124regulation of hexokinase activity (GO:1903299)2.83059582
125regulation of glucokinase activity (GO:0033131)2.83059582
126alanine transport (GO:0032328)2.82768857
1274-hydroxyproline metabolic process (GO:0019471)2.82141967
128membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.82018150
129ER to Golgi vesicle-mediated transport (GO:0006888)2.82006932
130positive regulation of receptor internalization (GO:0002092)2.81341478
131zinc ion transport (GO:0006829)2.80874699
132Golgi organization (GO:0007030)2.78444726
133neuron fate specification (GO:0048665)2.77771287
134peptidyl-proline hydroxylation (GO:0019511)2.76595285
135cellular response to vitamin D (GO:0071305)2.76547098
136response to monosaccharide (GO:0034284)2.76219332
137protein targeting to Golgi (GO:0000042)2.76151185
138negative regulation of peptide hormone secretion (GO:0090278)2.75530001
139negative regulation of glycoprotein biosynthetic process (GO:0010561)2.75415250
140zinc ion homeostasis (GO:0055069)2.68208036
141cellular response to hexose stimulus (GO:0071331)2.67391758
142cobalamin metabolic process (GO:0009235)2.66977988
143regulation of extracellular matrix disassembly (GO:0010715)2.66806903
144negative regulation of peptide secretion (GO:0002792)2.66106727
145regulation of glucocorticoid secretion (GO:2000849)2.65923677
146nitric oxide biosynthetic process (GO:0006809)2.64438409
147calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.63645062
148iron coordination entity transport (GO:1901678)2.61706664
149regulation of acrosome reaction (GO:0060046)2.60619663
150regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.59614747
151ovulation from ovarian follicle (GO:0001542)2.58470127
152regulation of inclusion body assembly (GO:0090083)2.55999625
153endothelial cell differentiation (GO:0045446)2.54439986
154leukocyte tethering or rolling (GO:0050901)2.51440405
155regulation of energy homeostasis (GO:2000505)2.51319161
156regulation of heart rate by cardiac conduction (GO:0086091)2.51017288
157positive regulation of glycolytic process (GO:0045821)2.49470803
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.48768288
159L-phenylalanine catabolic process (GO:0006559)2.48768288
160sphingomyelin metabolic process (GO:0006684)2.48676311
161dentate gyrus development (GO:0021542)2.48529570
162regulation of cell proliferation involved in kidney development (GO:1901722)2.47281507
163negative regulation of gluconeogenesis (GO:0045721)2.44622040
164inositol phosphate-mediated signaling (GO:0048016)2.43979549
165cytochrome complex assembly (GO:0017004)2.43791914
166macroautophagy (GO:0016236)2.43411167
167membrane repolarization during action potential (GO:0086011)2.42439513
168cellular response to zinc ion (GO:0071294)2.42279197
169cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41571767
170cellular zinc ion homeostasis (GO:0006882)2.40806013
171vitamin transport (GO:0051180)2.40322670
172respiratory chain complex IV assembly (GO:0008535)2.36674530
173magnesium ion transport (GO:0015693)2.34917910
174L-phenylalanine metabolic process (GO:0006558)2.34244866
175erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34244866
176retinol metabolic process (GO:0042572)2.32951989
177urate metabolic process (GO:0046415)2.31272475
178purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.30663757
1793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.30663757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.68433374
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.76629163
3EZH2_22144423_ChIP-Seq_EOC_Human3.54250805
4DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.48313343
5GATA1_22025678_ChIP-Seq_K562_Human3.02835578
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.48972347
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26580289
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21141300
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.16052350
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98155906
11REST_21632747_ChIP-Seq_MESCs_Mouse1.93684736
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84517564
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81499660
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79447470
15SOX2_27498859_Chip-Seq_STOMACH_Mouse1.78092602
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77861464
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77061295
18* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73485953
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73391039
20ZNF274_21170338_ChIP-Seq_K562_Hela1.68577109
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.60167017
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57112688
23HTT_18923047_ChIP-ChIP_STHdh_Human1.50204190
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.48511934
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48272607
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.46717879
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.45960115
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45675272
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45259220
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.43889443
31* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43889053
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.43570873
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42604276
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42469893
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42385261
36OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.41457097
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40772737
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.40360733
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38792654
40SOX2_20726797_ChIP-Seq_SW620_Human1.38240787
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.37904021
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36406000
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36358764
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34963782
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34112419
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32895716
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28422319
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.28039400
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.27400587
50FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.24637306
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24477173
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.24399953
53CTCF_27219007_Chip-Seq_Bcells_Human1.24345607
54* BCAT_22108803_ChIP-Seq_LS180_Human1.21671320
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.19254783
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19233983
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19113334
58EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19065170
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18472182
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18220973
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17272470
62RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15209832
63AR_25329375_ChIP-Seq_VCAP_Human1.15138912
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14953241
65CDX2_22108803_ChIP-Seq_LS180_Human1.12143658
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.11950670
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11795569
68DROSHA_22980978_ChIP-Seq_HELA_Human1.11194077
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11016014
70AHR_22903824_ChIP-Seq_MCF-7_Human1.10579256
71* SMAD4_21799915_ChIP-Seq_A2780_Human1.10578698
72* P300_19829295_ChIP-Seq_ESCs_Human1.10116981
73LXR_22292898_ChIP-Seq_THP-1_Human1.09916711
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09287414
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.07898106
76GATA4_25053715_ChIP-Seq_YYC3_Human1.07287166
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.06301455
78RNF2_27304074_Chip-Seq_NSC_Mouse1.06276727
79TP53_22573176_ChIP-Seq_HFKS_Human1.06130001
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.04659548
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04590614
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04551258
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.04386313
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.02652563
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02560655
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02500646
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.02391426
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.01974807
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.01884229
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01728195
91CREB1_26743006_Chip-Seq_LNCaP_Human1.01191258
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01089808
93EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01088362
94RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01088362
95* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00660981
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99397960
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99326855
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98536519
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.97861075
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96802100
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96314433
102PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96160840
103CBX2_27304074_Chip-Seq_ESCs_Mouse0.95970997
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95951860
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95542980
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94998648
107KDM2B_26808549_Chip-Seq_K562_Human0.94685684
108* SOX2_19829295_ChIP-Seq_ESCs_Human0.94042473
109* NANOG_19829295_ChIP-Seq_ESCs_Human0.94042473
110RUNX2_22187159_ChIP-Seq_PCA_Human0.93980950
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93970303
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93889270
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93012508
114VDR_22108803_ChIP-Seq_LS180_Human0.92111733
115RXR_22158963_ChIP-Seq_LIVER_Mouse0.91741089
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91669403
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.91131497
118FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91002664
119STAT3_18555785_Chip-Seq_ESCs_Mouse0.90804722
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90665969
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90577298
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90576115
123TCF4_22108803_ChIP-Seq_LS180_Human0.90285174
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89365056
125SOX2_18555785_Chip-Seq_ESCs_Mouse0.89225671
126* CJUN_26792858_Chip-Seq_BT549_Human0.89044507
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.89000981
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88349778
129EZH2_27304074_Chip-Seq_ESCs_Mouse0.87902023
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87821431
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87470675
132FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85866277
133FOXA1_25329375_ChIP-Seq_VCAP_Human0.85866277
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.85608589
135* KLF4_19829295_ChIP-Seq_ESCs_Human0.85543129
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.84545086
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84166546
138TP63_23658742_ChIP-Seq_EP156T_Human0.84091420
139GBX2_23144817_ChIP-Seq_PC3_Human0.84085479
140P53_22387025_ChIP-Seq_ESCs_Mouse0.83934496
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83659051
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83480194
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.83375292
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83145284
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82959484
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82925332
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82896776
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82693001
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.82558706
150GATA1_19941826_ChIP-Seq_K562_Human0.82557302
151STAT3_23295773_ChIP-Seq_U87_Human0.82446517
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.81351619
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81288643
154FOXH1_21741376_ChIP-Seq_ESCs_Human0.81140382
155SMC4_20622854_ChIP-Seq_HELA_Human0.79748397
156GF1_26923725_Chip-Seq_HPCs_Mouse0.79256765
157ERG_20517297_ChIP-Seq_VCAP_Human0.78452224
158REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78340698
159GATA6_25053715_ChIP-Seq_YYC3_Human0.78024514
160TP63_22573176_ChIP-Seq_HFKS_Human0.77084670
161GATA3_21867929_ChIP-Seq_CD8_Mouse0.76794626
162JARID2_20064375_ChIP-Seq_MESCs_Mouse0.76629590
163ETS1_21867929_ChIP-Seq_TH2_Mouse0.75870410
164* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74024091
165AR_19668381_ChIP-Seq_PC3_Human0.73980813
166LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73628855
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.73533723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005220_abnormal_exocrine_pancreas4.81804215
2MP0004043_abnormal_pH_regulation4.43617966
3MP0002693_abnormal_pancreas_physiology4.39792327
4MP0001944_abnormal_pancreas_morphology3.76655961
5MP0002877_abnormal_melanocyte_morpholog3.75946393
6MP0000678_abnormal_parathyroid_gland3.75844556
7MP0001666_abnormal_nutrient_absorption3.52196817
8MP0002909_abnormal_adrenal_gland3.47908034
9MP0003283_abnormal_digestive_organ3.38623698
10MP0005083_abnormal_biliary_tract3.37500039
11MP0005365_abnormal_bile_salt2.92354024
12MP0009780_abnormal_chondrocyte_physiolo2.83215250
13MP0003195_calcinosis2.82104452
14MP0002254_reproductive_system_inflammat2.78842428
15MP0000013_abnormal_adipose_tissue2.77519406
16MP0001879_abnormal_lymphatic_vessel2.77458367
17MP0002163_abnormal_gland_morphology2.61271900
18MP0002837_dystrophic_cardiac_calcinosis2.48548868
19MP0010386_abnormal_urinary_bladder2.43153385
20MP0004264_abnormal_extraembryonic_tissu2.34709554
21MP0005167_abnormal_blood-brain_barrier2.32390098
22MP0003868_abnormal_feces_composition2.14246685
23MP0001849_ear_inflammation2.14171570
24MP0002078_abnormal_glucose_homeostasis2.12438887
25MP0003724_increased_susceptibility_to2.11448806
26MP0006072_abnormal_retinal_apoptosis2.08379422
27MP0010368_abnormal_lymphatic_system2.07685542
28MP0005379_endocrine/exocrine_gland_phen2.04024730
29MP0003183_abnormal_peptide_metabolism1.95809674
30MP0005084_abnormal_gallbladder_morpholo1.80636018
31MP0005646_abnormal_pituitary_gland1.78397735
32MP0004019_abnormal_vitamin_homeostasis1.76265896
33MP0002234_abnormal_pharynx_morphology1.74652000
34MP0000516_abnormal_urinary_system1.73374973
35MP0005367_renal/urinary_system_phenotyp1.73374973
36MP0002928_abnormal_bile_duct1.67237232
37MP0000003_abnormal_adipose_tissue1.65178520
38MP0003172_abnormal_lysosome_physiology1.61213133
39MP0002638_abnormal_pupillary_reflex1.56879419
40MP0010329_abnormal_lipoprotein_level1.54049412
41MP0005409_darkened_coat_color1.51084629
42MP0008961_abnormal_basal_metabolism1.47617264
43MP0000631_abnormal_neuroendocrine_gland1.44157175
44MP0008004_abnormal_stomach_pH1.43269734
45MP0003953_abnormal_hormone_level1.42930402
46MP0001765_abnormal_ion_homeostasis1.39791446
47MP0002876_abnormal_thyroid_physiology1.38663480
48MP0009840_abnormal_foam_cell1.35308582
49MP0004133_heterotaxia1.34862597
50MP0003959_abnormal_lean_body1.34495400
51MP0001986_abnormal_taste_sensitivity1.34329107
52MP0003303_peritoneal_inflammation1.33477692
53MP0004270_analgesia1.32616243
54MP0001664_abnormal_digestion1.31504689
55MP0001501_abnormal_sleep_pattern1.29971077
56MP0010234_abnormal_vibrissa_follicle1.29591853
57MP0003122_maternal_imprinting1.28771781
58MP0005645_abnormal_hypothalamus_physiol1.26375021
59MP0009046_muscle_twitch1.26299690
60MP0005448_abnormal_energy_balance1.25685877
61MP0000681_abnormal_thyroid_gland1.25018628
62MP0002138_abnormal_hepatobiliary_system1.24747633
63MP0004147_increased_porphyrin_level1.24687528
64MP0005332_abnormal_amino_acid1.23319173
65MP0000613_abnormal_salivary_gland1.22268720
66MP0000462_abnormal_digestive_system1.22154025
67MP0003119_abnormal_digestive_system1.19807874
68MP0001270_distended_abdomen1.19576193
69MP0003638_abnormal_response/metabolism_1.18974565
70MP0001348_abnormal_lacrimal_gland1.18114051
71MP0004782_abnormal_surfactant_physiolog1.13447207
72MP0004185_abnormal_adipocyte_glucose1.12561130
73MP0002896_abnormal_bone_mineralization1.11322929
74MP0004484_altered_response_of1.09554554
75MP0009643_abnormal_urine_homeostasis1.06742132
76MP0003879_abnormal_hair_cell1.06400530
77MP0004215_abnormal_myocardial_fiber1.05824148
78MP0005535_abnormal_body_temperature1.04566430
79MP0005375_adipose_tissue_phenotype1.03351535
80MP0004858_abnormal_nervous_system1.02291350
81MP0003300_gastrointestinal_ulcer1.02284603
82MP0005187_abnormal_penis_morphology0.98911898
83MP0002277_abnormal_respiratory_mucosa0.98644352
84MP0005085_abnormal_gallbladder_physiolo0.98581603
85MP0001851_eye_inflammation0.98019716
86MP0009745_abnormal_behavioral_response0.96925439
87MP0005058_abnormal_lysosome_morphology0.96431233
88MP0005253_abnormal_eye_physiology0.90757293
89MP0000343_altered_response_to0.90052792
90MP0003011_delayed_dark_adaptation0.88010018
91MP0001502_abnormal_circadian_rhythm0.87563775
92MP0005408_hypopigmentation0.85536954
93MP0000015_abnormal_ear_pigmentation0.85421209
94MP0002118_abnormal_lipid_homeostasis0.84890224
95MP0005551_abnormal_eye_electrophysiolog0.84767292
96MP0010678_abnormal_skin_adnexa0.84719798
97MP0004885_abnormal_endolymph0.84149592
98MP0003943_abnormal_hepatobiliary_system0.83690278
99MP0004145_abnormal_muscle_electrophysio0.83003391
100MP0002139_abnormal_hepatobiliary_system0.82983079
101MP0000049_abnormal_middle_ear0.80979917
102MP0010352_gastrointestinal_tract_polyps0.80668642
103MP0002127_abnormal_cardiovascular_syste0.80609564
104MP0003045_fibrosis0.80410215
105MP0000767_abnormal_smooth_muscle0.79934663
106MP0004085_abnormal_heartbeat0.79594906
107MP0003787_abnormal_imprinting0.79575680
108MP0003633_abnormal_nervous_system0.78293451
109MP0004859_abnormal_synaptic_plasticity0.77713308
110MP0006292_abnormal_olfactory_placode0.75451619
111MP0005389_reproductive_system_phenotype0.75042771
112MP0000230_abnormal_systemic_arterial0.74594488
113MP0005636_abnormal_mineral_homeostasis0.74581238
114MP0002177_abnormal_outer_ear0.74100636
115MP0001764_abnormal_homeostasis0.73476030
116MP0003075_altered_response_to0.72877874
117MP0002295_abnormal_pulmonary_circulatio0.72228790
118MP0004510_myositis0.71342882
119MP0002064_seizures0.70059534
120MP0002069_abnormal_eating/drinking_beha0.67614661
121MP0001177_atelectasis0.67587589
122MP0003279_aneurysm0.64509794
123MP0000465_gastrointestinal_hemorrhage0.64386070
124MP0001299_abnormal_eye_distance/0.63432442
125MP0003252_abnormal_bile_duct0.62704289
126MP0001905_abnormal_dopamine_level0.62664928
127MP0001756_abnormal_urination0.62009846
128MP0002751_abnormal_autonomic_nervous0.61616252
129MP0003329_amyloid_beta_deposits0.61315218
130MP0006054_spinal_hemorrhage0.61118783
131MP0005334_abnormal_fat_pad0.60926492
132MP0005257_abnormal_intraocular_pressure0.60184268
133MP0003635_abnormal_synaptic_transmissio0.59954953
134MP0000955_abnormal_spinal_cord0.59702874
135MP0003186_abnormal_redox_activity0.59408351
136MP0002971_abnormal_brown_adipose0.58624617
137MP0002733_abnormal_thermal_nociception0.58593146
138MP0000470_abnormal_stomach_morphology0.56216600
139MP0002098_abnormal_vibrissa_morphology0.56070176
140MP0005166_decreased_susceptibility_to0.55849574
141MP0002557_abnormal_social/conspecific_i0.55446546
142MP0002160_abnormal_reproductive_system0.54574106
143MP0005310_abnormal_salivary_gland0.53400283
144MP0002090_abnormal_vision0.52817529
145MP0005670_abnormal_white_adipose0.52678157
146MP0009672_abnormal_birth_weight0.52327023

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)7.12040932
2Hyperinsulinemic hypoglycemia (HP:0000825)7.02010523
3Symptomatic seizures (HP:0011145)6.34108170
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.42912012
5Hypoglycemic coma (HP:0001325)5.30387673
6Abnormality of the pancreatic islet cells (HP:0006476)4.54274849
7Abnormality of endocrine pancreas physiology (HP:0012093)4.54274849
8Hemiparesis (HP:0001269)4.49383939
9Insulin-resistant diabetes mellitus (HP:0000831)4.48735756
10Ketoacidosis (HP:0001993)4.44817482
11Hyperglycemia (HP:0003074)4.37070622
12Vascular calcification (HP:0004934)4.19061443
13Large for gestational age (HP:0001520)4.15117176
14Pancreatic islet-cell hyperplasia (HP:0004510)4.01790572
15Late onset (HP:0003584)3.95362569
16Decreased circulating renin level (HP:0003351)3.89554889
17Hyperkalemia (HP:0002153)3.85950954
18Abnormality of calcium-phosphate metabolism (HP:0100530)3.77428764
19Cardiovascular calcification (HP:0011915)3.66314690
20Hypothermia (HP:0002045)3.64352854
21Hematochezia (HP:0002573)3.63895619
22Abnormal pancreas size (HP:0012094)3.56920221
23Polydipsia (HP:0001959)3.46830971
24Abnormal drinking behavior (HP:0030082)3.46830971
25Tubulointerstitial nephritis (HP:0001970)3.42770053
26Gout (HP:0001997)3.35342862
27Abnormality of vitamin B metabolism (HP:0004340)3.19757760
28Congenital stationary night blindness (HP:0007642)3.16835676
29Vacuolated lymphocytes (HP:0001922)3.09959935
30Increased CSF protein (HP:0002922)3.09190678
31Tubular atrophy (HP:0000092)3.03348188
32Abnormality of potassium homeostasis (HP:0011042)3.02845385
33Hypokalemia (HP:0002900)3.01646604
34Congenital, generalized hypertrichosis (HP:0004540)3.01612397
35Abnormality of the intrinsic pathway (HP:0010989)3.01496760
36Urinary glycosaminoglycan excretion (HP:0003541)2.99310632
37Mucopolysacchariduria (HP:0008155)2.99310632
38Lymphangioma (HP:0100764)2.95683615
39Chronic bronchitis (HP:0004469)2.90569133
40Congenital sensorineural hearing impairment (HP:0008527)2.87965596
41Dysostosis multiplex (HP:0000943)2.86298089
42Aplasia/hypoplasia of the uterus (HP:0008684)2.85136914
43Lip pit (HP:0100267)2.82023181
44Insulin resistance (HP:0000855)2.80692847
45Unilateral renal agenesis (HP:0000122)2.79365792
46Ketosis (HP:0001946)2.74884283
47Renal salt wasting (HP:0000127)2.70192989
48Delayed CNS myelination (HP:0002188)2.68320014
49Enlarged penis (HP:0000040)2.67723778
50Double outlet right ventricle (HP:0001719)2.67708386
51Congenital malformation of the right heart (HP:0011723)2.67708386
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66443462
53Abnormality of polysaccharide metabolism (HP:0011012)2.66443462
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66443462
55Abnormality of vitamin metabolism (HP:0100508)2.65211908
56Absent eyebrow (HP:0002223)2.62641664
57Hypokalemic alkalosis (HP:0001949)2.60694306
58Hyperphosphatemia (HP:0002905)2.59148125
59Tongue fasciculations (HP:0001308)2.57880731
60Hyperparathyroidism (HP:0000843)2.57831312
61Conjugated hyperbilirubinemia (HP:0002908)2.55199863
62Agitation (HP:0000713)2.53909956
63Exocrine pancreatic insufficiency (HP:0001738)2.53586917
64Abnormality of renin-angiotensin system (HP:0000847)2.53261646
65Intestinal atresia (HP:0011100)2.50486294
66Hyperactive renin-angiotensin system (HP:0000841)2.50247195
67Abnormality of the renal cortex (HP:0011035)2.48969427
68Osteomalacia (HP:0002749)2.46407373
69Abnormality of chloride homeostasis (HP:0011422)2.44660159
70Epileptiform EEG discharges (HP:0011182)2.42669537
71Pancreatic fibrosis (HP:0100732)2.40266240
72EEG with generalized epileptiform discharges (HP:0011198)2.39282105
73Hypsarrhythmia (HP:0002521)2.38628016
74Congenital glaucoma (HP:0001087)2.37964707
75Retinal atrophy (HP:0001105)2.35625569
76Muscle fibrillation (HP:0010546)2.34992348
77Stenosis of the external auditory canal (HP:0000402)2.33460711
78Polyuria (HP:0000103)2.32007976
79Maternal diabetes (HP:0009800)2.31930383
80Pancreatic cysts (HP:0001737)2.31255230
81Prominent metopic ridge (HP:0005487)2.29719662
82Hyperthyroidism (HP:0000836)2.28241461
83Visual hallucinations (HP:0002367)2.26211565
84Chronic hepatic failure (HP:0100626)2.25935697
85Cortical visual impairment (HP:0100704)2.25530967
86Progressive neurologic deterioration (HP:0002344)2.24493961
87Syncope (HP:0001279)2.22990083
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21623723
89Diplopia (HP:0000651)2.18377267
90Abnormality of binocular vision (HP:0011514)2.18377267
91Prolonged QT interval (HP:0001657)2.17123249
92Hypotension (HP:0002615)2.16895493
93Enlarged kidneys (HP:0000105)2.15537567
94Hyperaldosteronism (HP:0000859)2.15126257
95Hypoplasia of the uterus (HP:0000013)2.14825542
96Renal cortical cysts (HP:0000803)2.13419459
97Abnormality of urine glucose concentration (HP:0011016)2.13328572
98Glycosuria (HP:0003076)2.13328572
99Facial shape deformation (HP:0011334)2.13312808
100Potter facies (HP:0002009)2.13312808
101Episodic fever (HP:0001954)2.13145246
102Xanthomatosis (HP:0000991)2.12435506
103Chronic sinusitis (HP:0011109)2.12340383
104Type I diabetes mellitus (HP:0100651)2.12312803
105Tetraparesis (HP:0002273)2.11747645
106Absence seizures (HP:0002121)2.11273907
107Hydroureter (HP:0000072)2.11258821
108Tubulointerstitial abnormality (HP:0001969)2.10312707
109Adrenal overactivity (HP:0002717)2.09880532
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09111469
111Abnormal protein N-linked glycosylation (HP:0012347)2.09111469
112Abnormal protein glycosylation (HP:0012346)2.09111469
113Abnormal glycosylation (HP:0012345)2.09111469
114Nonimmune hydrops fetalis (HP:0001790)2.06091965
115Abnormality of magnesium homeostasis (HP:0004921)2.05061540
116Hypercortisolism (HP:0001578)2.04634807
117Ventricular fibrillation (HP:0001663)2.03343867
118Decreased subcutaneous fat (HP:0001002)2.02986543
119Abnormal urine output (HP:0012590)2.00797715
120Methylmalonic acidemia (HP:0002912)1.98926383
121Hypomagnesemia (HP:0002917)1.97846245
122Abnormal biliary tract morphology (HP:0012440)1.97806451
123Cystic liver disease (HP:0006706)1.97473249
124Hypokinesia (HP:0002375)1.96963637
125Dysautonomia (HP:0002459)1.95859285
126Urethral obstruction (HP:0000796)1.95427420
127Hypotrichosis (HP:0001006)1.95075415
128Methylmalonic aciduria (HP:0012120)1.94785348
129Abdominal distention (HP:0003270)1.91712989
130Decreased central vision (HP:0007663)1.91172795
131Testicular neoplasm (HP:0010788)1.90483780
132Popliteal pterygium (HP:0009756)1.90262792
133Hypoplasia of the fovea (HP:0007750)1.89518631
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.89518631
135Abnormal EKG (HP:0003115)1.87867455
136Increased circulating renin level (HP:0000848)1.86351733
137Postural tremor (HP:0002174)1.85226949
138Generalized aminoaciduria (HP:0002909)1.84730285
139Villous atrophy (HP:0011473)1.84692603
140Abnormality of small intestinal villus morphology (HP:0011472)1.84692603
141Dialeptic seizures (HP:0011146)1.83638574
142Tubulointerstitial fibrosis (HP:0005576)1.83628793
143Abnormality of the metopic suture (HP:0005556)1.83526794
144Bone cyst (HP:0012062)1.82594696
145Abnormal sex determination (HP:0012244)1.81180303
146Sex reversal (HP:0012245)1.81180303
147Confusion (HP:0001289)1.81121576
148Type II diabetes mellitus (HP:0005978)1.80935546
149Mixed hearing impairment (HP:0000410)1.80683846
150Palpebral edema (HP:0100540)1.80604671
151Metaphyseal dysplasia (HP:0100255)1.80271896
152Alkalosis (HP:0001948)1.79801897
153Progressive macrocephaly (HP:0004481)1.79525077
154Abnormality of purine metabolism (HP:0004352)1.79207041
155Aplasia/Hypoplasia of the spleen (HP:0010451)1.78935473
156Abnormality of the renal medulla (HP:0100957)1.77907885
157Hyponatremia (HP:0002902)1.76941610
158Abnormality of renal excretion (HP:0011036)1.75503440
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74363062
160Morphological abnormality of the middle ear (HP:0008609)1.72352385
161Abnormality of the common coagulation pathway (HP:0010990)1.71831788
162Renal dysplasia (HP:0000110)1.71534565
163Bronchitis (HP:0012387)1.71236307
164Tachypnea (HP:0002789)1.70208972
165Turricephaly (HP:0000262)1.69406971
166Fat malabsorption (HP:0002630)1.67876061
167Deep palmar crease (HP:0006191)1.66871685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.03747279
2INSRR5.97478948
3MAPK155.82894821
4TSSK64.89088298
5PASK4.31343273
6ERN13.36466574
7PRKD33.23514039
8WNK43.20933747
9MAP3K23.07867781
10GRK13.07431750
11TAOK32.82156252
12HIPK22.45621909
13NTRK32.45061065
14BCKDK2.18108413
15DAPK22.14481021
16MAP4K22.14026154
17MST42.08625800
18CAMKK22.03282044
19FGFR21.82617170
20FER1.77443127
21PHKG21.77003701
22PHKG11.77003701
23MAP3K11.66801310
24IRAK31.61655073
25PINK11.61473712
26EIF2AK31.58551024
27FLT31.58268150
28MAP2K21.55289164
29TRIB31.54101885
30PTK61.51712399
31BCR1.49621609
32NTRK11.48502644
33ADRBK21.47288057
34EPHA31.46981019
35FRK1.45942575
36TRPM71.45298611
37CDC42BPA1.39438552
38STK241.38352544
39FGFR31.37692747
40NME11.37334455
41PTK21.35658543
42MAPKAPK31.34443724
43OXSR11.31153504
44BMPR1B1.23848996
45STK31.16562864
46CAMKK11.15333699
47MARK21.14533478
48IRAK11.12036660
49WNK31.11847490
50PAK31.09613856
51UHMK11.07770648
52PDGFRA1.03687811
53PRKD21.01989817
54EPHB20.99993587
55PDGFRB0.99518357
56EPHA20.98261633
57SIK10.95417081
58STK38L0.88665666
59TAOK10.87701641
60TESK10.85025550
61MAP3K40.84454321
62PRKCH0.81705867
63CSNK1G10.80523266
64TEC0.77981978
65CDK120.76938718
66TLK10.74713927
67DYRK1B0.74065882
68CAMK1G0.73563773
69PRKCI0.73118717
70EPHB10.72206089
71PRKCE0.70922383
72RPS6KA50.69139891
73SCYL20.68527008
74IKBKB0.67316993
75RIPK40.66897883
76MAP3K30.65579131
77MET0.64734847
78TBK10.64349709
79CDK30.63472291
80RIPK10.63260415
81WNK10.63088037
82ZAP700.61720446
83MAP3K70.61332877
84PRKAA20.61330081
85TNK20.61060737
86ITK0.60635634
87CAMK2B0.60569804
88PIK3CG0.60323642
89CAMK2D0.59926360
90NLK0.59819111
91BRSK20.56441855
92PRKCQ0.55278778
93VRK10.53906777
94CAMK10.52583860
95MAP3K90.52446820
96RET0.51472163
97KDR0.50815353
98GSK3A0.50521100
99MAP3K120.50226749
100IRAK20.49269066
101PRKD10.48319860
102NEK60.47760654
103ABL20.47589586
104MAP3K140.46428812
105MAP2K60.46036031
106MAP2K10.44371091
107AKT30.43207529
108KSR20.43011766
109IKBKE0.42739951
110STK110.42538976
111DDR20.40578888
112DYRK1A0.37939480
113EPHA40.37383820
114PRKCG0.36795000
115PTK2B0.36600837
116MARK30.35200901
117CASK0.35011894
118PIK3CA0.34582688
119OBSCN0.34346410
120MYLK0.34188636
121IRAK40.34132086
122CSNK1A1L0.34090390
123STK40.33918721
124CSNK1G20.33103701
125PRKACA0.32553499
126CDK50.32013370
127BRAF0.31816787
128CAMK2A0.31584534
129RPS6KA20.31316413
130IGF1R0.30853240
131ACVR1B0.30556356
132PKN20.30438232
133STK390.30406279
134ERBB30.28178506
135MTOR0.26969290
136CHUK0.26595609
137CSNK1G30.25977439
138FGFR40.25595910
139BMPR20.25573761
140PRKACB0.24431931
141SGK10.23971410
142JAK20.23683150
143CSNK1A10.23647397
144EGFR0.23601293
145PRKACG0.23293629
146PNCK0.22118949
147PRKAA10.21727850
148ADRBK10.20988511
149STK380.20954893
150PDPK10.19996070
151GRK50.19780926
152PRKCA0.19029037
153RPS6KA30.18662438
154RPS6KB10.18528605
155ERBB20.17688996

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.38060381
2Protein export_Homo sapiens_hsa030604.71278507
3Pancreatic secretion_Homo sapiens_hsa049723.78352574
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.09860136
5Insulin secretion_Homo sapiens_hsa049113.08886739
6Vibrio cholerae infection_Homo sapiens_hsa051102.20044307
7Sulfur metabolism_Homo sapiens_hsa009202.15822136
8Protein digestion and absorption_Homo sapiens_hsa049742.07065508
9Vitamin B6 metabolism_Homo sapiens_hsa007502.05626624
10Type II diabetes mellitus_Homo sapiens_hsa049302.04423552
11Fat digestion and absorption_Homo sapiens_hsa049752.01960297
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99872731
13Type I diabetes mellitus_Homo sapiens_hsa049401.83318762
14Butanoate metabolism_Homo sapiens_hsa006501.77490872
15Cocaine addiction_Homo sapiens_hsa050301.69712623
16Folate biosynthesis_Homo sapiens_hsa007901.66779949
17African trypanosomiasis_Homo sapiens_hsa051431.62061244
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.59908349
19Amphetamine addiction_Homo sapiens_hsa050311.58567628
20N-Glycan biosynthesis_Homo sapiens_hsa005101.52468626
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45667150
22Selenocompound metabolism_Homo sapiens_hsa004501.41920956
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.41230716
24Phototransduction_Homo sapiens_hsa047441.40426010
25Collecting duct acid secretion_Homo sapiens_hsa049661.31586047
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29256512
27Ether lipid metabolism_Homo sapiens_hsa005651.27518103
28Other glycan degradation_Homo sapiens_hsa005111.25314580
29Taste transduction_Homo sapiens_hsa047421.21686921
30Legionellosis_Homo sapiens_hsa051341.15347352
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14620295
32Nitrogen metabolism_Homo sapiens_hsa009101.09498807
33Rheumatoid arthritis_Homo sapiens_hsa053231.09171250
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09080994
35Lysosome_Homo sapiens_hsa041421.07161467
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04665864
37Synaptic vesicle cycle_Homo sapiens_hsa047211.04205082
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04162716
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96519735
40Long-term potentiation_Homo sapiens_hsa047200.95265857
41Glucagon signaling pathway_Homo sapiens_hsa049220.93635621
42Glycerolipid metabolism_Homo sapiens_hsa005610.93343408
43Linoleic acid metabolism_Homo sapiens_hsa005910.93338479
44Circadian entrainment_Homo sapiens_hsa047130.93324585
45Insulin resistance_Homo sapiens_hsa049310.91850078
46Ovarian steroidogenesis_Homo sapiens_hsa049130.91824601
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88756289
48Circadian rhythm_Homo sapiens_hsa047100.88596350
49Caffeine metabolism_Homo sapiens_hsa002320.86967309
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84639515
51Thyroid hormone synthesis_Homo sapiens_hsa049180.84373083
52Bile secretion_Homo sapiens_hsa049760.81981840
53Complement and coagulation cascades_Homo sapiens_hsa046100.80392416
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80163237
55beta-Alanine metabolism_Homo sapiens_hsa004100.78979962
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78093079
57Retinol metabolism_Homo sapiens_hsa008300.78088528
58Cholinergic synapse_Homo sapiens_hsa047250.77192969
59Peroxisome_Homo sapiens_hsa041460.76587636
60Dopaminergic synapse_Homo sapiens_hsa047280.76562129
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75041585
62GABAergic synapse_Homo sapiens_hsa047270.73978141
63Galactose metabolism_Homo sapiens_hsa000520.72703127
64Estrogen signaling pathway_Homo sapiens_hsa049150.71789947
65Sphingolipid metabolism_Homo sapiens_hsa006000.70073131
66Malaria_Homo sapiens_hsa051440.69468232
67TNF signaling pathway_Homo sapiens_hsa046680.69460254
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69425330
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68734950
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.68644421
71Tight junction_Homo sapiens_hsa045300.67536040
72Arachidonic acid metabolism_Homo sapiens_hsa005900.65863210
73cAMP signaling pathway_Homo sapiens_hsa040240.62837749
74Fatty acid elongation_Homo sapiens_hsa000620.60336599
75ABC transporters_Homo sapiens_hsa020100.59811305
76Chemical carcinogenesis_Homo sapiens_hsa052040.59810036
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59664581
78Tryptophan metabolism_Homo sapiens_hsa003800.59314672
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58726380
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58463941
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57818120
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57190254
83Pertussis_Homo sapiens_hsa051330.56646616
84Prion diseases_Homo sapiens_hsa050200.56191971
85Prolactin signaling pathway_Homo sapiens_hsa049170.55544107
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54890906
87Gastric acid secretion_Homo sapiens_hsa049710.53257905
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53038153
89Serotonergic synapse_Homo sapiens_hsa047260.52600151
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52259582
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52007171
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51028851
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50187030
94Morphine addiction_Homo sapiens_hsa050320.50082709
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49340023
96Glutamatergic synapse_Homo sapiens_hsa047240.48941985
97Starch and sucrose metabolism_Homo sapiens_hsa005000.46008217
98Renin-angiotensin system_Homo sapiens_hsa046140.45373870
99MAPK signaling pathway_Homo sapiens_hsa040100.45062608
100Histidine metabolism_Homo sapiens_hsa003400.44381575
101Calcium signaling pathway_Homo sapiens_hsa040200.44096048
102Insulin signaling pathway_Homo sapiens_hsa049100.43319500
103Propanoate metabolism_Homo sapiens_hsa006400.43248009
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43079490
105Hepatitis C_Homo sapiens_hsa051600.42905274
106Regulation of autophagy_Homo sapiens_hsa041400.42579424
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.40960729
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.40940072
109Arginine and proline metabolism_Homo sapiens_hsa003300.40317094
110Renin secretion_Homo sapiens_hsa049240.39934734
111Salivary secretion_Homo sapiens_hsa049700.38641688
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38513215
113Salmonella infection_Homo sapiens_hsa051320.38464722
114Alzheimers disease_Homo sapiens_hsa050100.38247958
115Dorso-ventral axis formation_Homo sapiens_hsa043200.37242761
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37206521
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36797651
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33594555
119Oxidative phosphorylation_Homo sapiens_hsa001900.33180183
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31849516
121Thyroid cancer_Homo sapiens_hsa052160.30201687
122Fatty acid degradation_Homo sapiens_hsa000710.29398310
123Melanogenesis_Homo sapiens_hsa049160.28963469
124Alcoholism_Homo sapiens_hsa050340.28640144
125Nicotine addiction_Homo sapiens_hsa050330.27460852
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26723254
127Long-term depression_Homo sapiens_hsa047300.26111808
128Inositol phosphate metabolism_Homo sapiens_hsa005620.25626205
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25498465
130GnRH signaling pathway_Homo sapiens_hsa049120.25205076
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24640198
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22740813
133Gap junction_Homo sapiens_hsa045400.22710783
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22005951
135Lysine degradation_Homo sapiens_hsa003100.21777566
136Mineral absorption_Homo sapiens_hsa049780.20401146
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.20189304
138Vitamin digestion and absorption_Homo sapiens_hsa049770.20079961
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18846601

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