ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	respiratory chain complex IV assembly (GO:0008535)	4.05717249
2	cytochrome complex assembly (GO:0017004)	3.47046378
3	protein localization to cilium (GO:0061512)	3.46384123
4	DNA double-strand break processing (GO:0000729)	3.45111491
5	behavioral response to nicotine (GO:0035095)	3.42114989
6	fucose catabolic process (GO:0019317)	3.38251888
7	L-fucose metabolic process (GO:0042354)	3.38251888
8	L-fucose catabolic process (GO:0042355)	3.38251888
9	response to pheromone (GO:0019236)	3.34441973
10	nonmotile primary cilium assembly (GO:0035058)	3.33019869
11	retinal cone cell development (GO:0046549)	3.27048016
12	protein complex biogenesis (GO:0070271)	3.26557027
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.21914958
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16913355
15	NADH dehydrogenase complex assembly (GO:0010257)	3.16913355
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16913355
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16834593
18	axoneme assembly (GO:0035082)	3.15032728
19	cullin deneddylation (GO:0010388)	3.13723435
20	replication fork processing (GO:0031297)	3.11049612
21	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.10659943
22	negative regulation of telomere maintenance (GO:0032205)	3.09115783
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.07579389
24	cellular ketone body metabolic process (GO:0046950)	3.07270691
25	piRNA metabolic process (GO:0034587)	3.06578550
26	platelet dense granule organization (GO:0060155)	3.05078628
27	epithelial cilium movement (GO:0003351)	3.00003010
28	mannosylation (GO:0097502)	2.94435880
29	telomere maintenance via telomerase (GO:0007004)	2.92594681
30	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.91771254
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89591820
32	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.89579421
33	ATP synthesis coupled proton transport (GO:0015986)	2.89579421
34	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.89012578
35	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.89012578
36	proteasome assembly (GO:0043248)	2.88599613
37	regulation of glucokinase activity (GO:0033131)	2.86122642
38	regulation of hexokinase activity (GO:1903299)	2.86122642
39	regulation of meiosis I (GO:0060631)	2.83899579
40	detection of light stimulus involved in sensory perception (GO:0050962)	2.83229105
41	detection of light stimulus involved in visual perception (GO:0050908)	2.83229105
42	protein polyglutamylation (GO:0018095)	2.83157806
43	centriole replication (GO:0007099)	2.83076475
44	photoreceptor cell maintenance (GO:0045494)	2.82978737
45	protein K6-linked ubiquitination (GO:0085020)	2.79809803
46	single strand break repair (GO:0000012)	2.79805699
47	protein deneddylation (GO:0000338)	2.78537203
48	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.77285741
49	regulation of mitotic spindle checkpoint (GO:1903504)	2.77285741
50	synapsis (GO:0007129)	2.76394393
51	cilium morphogenesis (GO:0060271)	2.75999338
52	ketone body metabolic process (GO:1902224)	2.74810741
53	resolution of meiotic recombination intermediates (GO:0000712)	2.71820954
54	regulation of cilium movement (GO:0003352)	2.69932431
55	pseudouridine synthesis (GO:0001522)	2.68284367
56	neural tube formation (GO:0001841)	2.68246551
57	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67545433
58	dopamine transport (GO:0015872)	2.66613805
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65784484
60	intraciliary transport (GO:0042073)	2.65085958
61	cilium organization (GO:0044782)	2.64948107
62	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62891727
63	cilium assembly (GO:0042384)	2.60526826
64	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.56048096
65	DNA replication-dependent nucleosome assembly (GO:0006335)	2.55641133
66	DNA replication-dependent nucleosome organization (GO:0034723)	2.55641133
67	GPI anchor metabolic process (GO:0006505)	2.55437368
68	regulation of helicase activity (GO:0051095)	2.53865015
69	DNA methylation involved in gamete generation (GO:0043046)	2.53453174
70	chromatin remodeling at centromere (GO:0031055)	2.53267365
71	male meiosis (GO:0007140)	2.53106448
72	DNA catabolic process, exonucleolytic (GO:0000738)	2.51483860
73	cilium movement (GO:0003341)	2.50765359
74	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50540645
75	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50540645
76	recombinational repair (GO:0000725)	2.50094599
77	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.49508282
78	righting reflex (GO:0060013)	2.49356496
79	double-strand break repair via homologous recombination (GO:0000724)	2.48546805
80	regulation of acrosome reaction (GO:0060046)	2.47555873
81	protein-cofactor linkage (GO:0018065)	2.45417461
82	reciprocal DNA recombination (GO:0035825)	2.44939747
83	reciprocal meiotic recombination (GO:0007131)	2.44939747
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.44492913
85	somite rostral/caudal axis specification (GO:0032525)	2.43647036
86	DNA replication checkpoint (GO:0000076)	2.42341388
87	CENP-A containing nucleosome assembly (GO:0034080)	2.42110152
88	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.39312843
89	DNA damage response, detection of DNA damage (GO:0042769)	2.38900067
90	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.38888454
91	kidney morphogenesis (GO:0060993)	2.38463996
92	protein neddylation (GO:0045116)	2.38060898
93	reflex (GO:0060004)	2.36664814
94	DNA integration (GO:0015074)	2.35850631
95	maturation of 5.8S rRNA (GO:0000460)	2.32513655
96	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.29518959
97	rRNA modification (GO:0000154)	2.28798380
98	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.28614676
99	regulation of timing of cell differentiation (GO:0048505)	2.28099944
100	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.27515693

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.56420099
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.14617546
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.71337193
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69149750
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.59795876
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.53870950
7	VDR_22108803_ChIP-Seq_LS180_Human	2.48917053
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43053731
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.42834155
10	EWS_26573619_Chip-Seq_HEK293_Human	2.30673134
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30315487
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.29118074
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.28369840
14	FUS_26573619_Chip-Seq_HEK293_Human	2.24678223
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.23061945
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20276534
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.14465567
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.05897873
19	EZH2_22144423_ChIP-Seq_EOC_Human	2.00228477
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.97353028
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93877497
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.93414148
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.92000585
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91183677
25	P300_19829295_ChIP-Seq_ESCs_Human	1.90086859
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87893915
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74618822
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.73596915
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.71565407
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71011211
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.68546161
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66278467
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.66149740
34	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.65539414
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.61480196
36	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.61314090
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59637650
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.57349893
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51628650
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49284419
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.48640965
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48640965
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46045608
44	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.43750982
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43444620
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.41802118
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.40777506
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40445749
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37755100
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35417674
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.34419883
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32134422
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.31779325
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31069289
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30442074
56	STAT3_23295773_ChIP-Seq_U87_Human	1.28615873
57	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.28533923
58	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27617909
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27295614
60	AR_25329375_ChIP-Seq_VCAP_Human	1.26491302
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25129835
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24184604
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24047200
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23592528
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22555593
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22555593
67	TCF4_23295773_ChIP-Seq_U87_Human	1.21682921
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20363064
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19860745
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19860745
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18640447
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.16682788
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15039411
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14537943
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14158384
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.13561041
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12766529
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11714545
79	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.10592570
80	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09535257
81	NCOR_22424771_ChIP-Seq_293T_Human	1.09483937
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.07172163
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05510769
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05048574
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02554668
86	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00138215
87	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99713888
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99703510
89	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99565316
90	AR_20517297_ChIP-Seq_VCAP_Human	0.98012916
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97890427
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97706319
93	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96556100
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96290272
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95759293
96	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95550399
97	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95550399
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95165445
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93042708
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92872593

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.83290045
2	MP0003787_abnormal_imprinting	3.32462148
3	MP0003195_calcinosis	2.51155666
4	MP0003122_maternal_imprinting	2.45006546
5	MP0002102_abnormal_ear_morphology	2.32743291
6	MP0003718_maternal_effect	2.29287470
7	MP0001529_abnormal_vocalization	2.25711159
8	MP0006292_abnormal_olfactory_placode	2.24480827
9	MP0002163_abnormal_gland_morphology	2.19097854
10	MP0003121_genomic_imprinting	2.17553848
11	MP0001984_abnormal_olfaction	2.06190443
12	MP0008789_abnormal_olfactory_epithelium	2.05131988
13	MP0005551_abnormal_eye_electrophysiolog	1.99514271
14	MP0008058_abnormal_DNA_repair	1.85847735
15	MP0003880_abnormal_central_pattern	1.83581350
16	MP0002938_white_spotting	1.83566242
17	MP0002638_abnormal_pupillary_reflex	1.69200023
18	MP0004133_heterotaxia	1.68344957
19	MP0005394_taste/olfaction_phenotype	1.63291306
20	MP0005499_abnormal_olfactory_system	1.63291306
21	MP0003283_abnormal_digestive_organ	1.62675457
22	MP0002234_abnormal_pharynx_morphology	1.61183434
23	MP0006276_abnormal_autonomic_nervous	1.60319992
24	MP0006072_abnormal_retinal_apoptosis	1.59989052
25	MP0000631_abnormal_neuroendocrine_gland	1.58338779
26	MP0005379_endocrine/exocrine_gland_phen	1.57080442
27	MP0005645_abnormal_hypothalamus_physiol	1.56826105
28	MP0001986_abnormal_taste_sensitivity	1.55157484
29	MP0002160_abnormal_reproductive_system	1.51585556
30	MP0001968_abnormal_touch/_nociception	1.51406741
31	MP0004043_abnormal_pH_regulation	1.50001033
32	MP0008995_early_reproductive_senescence	1.49657827
33	MP0002837_dystrophic_cardiac_calcinosis	1.45401161
34	MP0003136_yellow_coat_color	1.45358243
35	MP0005646_abnormal_pituitary_gland	1.44252283
36	MP0005253_abnormal_eye_physiology	1.42552677
37	MP0009046_muscle_twitch	1.42387781
38	MP0000427_abnormal_hair_cycle	1.42058708
39	MP0009745_abnormal_behavioral_response	1.38600800
40	MP0003890_abnormal_embryonic-extraembry	1.37505208
41	MP0001293_anophthalmia	1.37408094
42	MP0008057_abnormal_DNA_replication	1.36862402
43	MP0010094_abnormal_chromosome_stability	1.35908533
44	MP0002736_abnormal_nociception_after	1.32996299
45	MP0002928_abnormal_bile_duct	1.31066027
46	MP0003693_abnormal_embryo_hatching	1.30525340
47	MP0002909_abnormal_adrenal_gland	1.29305074
48	MP0000372_irregular_coat_pigmentation	1.28645197
49	MP0008875_abnormal_xenobiotic_pharmacok	1.26543252
50	MP0004142_abnormal_muscle_tone	1.24142690
51	MP0000566_synostosis	1.21712820
52	MP0002557_abnormal_social/conspecific_i	1.21348377
53	MP0002272_abnormal_nervous_system	1.20565703
54	MP0002876_abnormal_thyroid_physiology	1.19768052
55	MP0005389_reproductive_system_phenotype	1.18843020
56	MP0002751_abnormal_autonomic_nervous	1.18059869
57	MP0003011_delayed_dark_adaptation	1.14332474
58	MP0002572_abnormal_emotion/affect_behav	1.13157467
59	MP0008872_abnormal_physiological_respon	1.10097276
60	MP0003119_abnormal_digestive_system	1.07576828
61	MP0002735_abnormal_chemical_nociception	1.07518794
62	MP0001905_abnormal_dopamine_level	1.07443953
63	MP0002734_abnormal_mechanical_nocicepti	1.07158680
64	MP0002210_abnormal_sex_determination	1.06879607
65	MP0002233_abnormal_nose_morphology	1.06794180
66	MP0002090_abnormal_vision	1.05490962
67	MP0004147_increased_porphyrin_level	1.05463723
68	MP0003123_paternal_imprinting	1.04929251
69	MP0005075_abnormal_melanosome_morpholog	1.02085574
70	MP0001929_abnormal_gametogenesis	1.01836351
71	MP0003937_abnormal_limbs/digits/tail_de	1.01324101
72	MP0000516_abnormal_urinary_system	1.00680046
73	MP0005367_renal/urinary_system_phenotyp	1.00680046
74	MP0003567_abnormal_fetal_cardiomyocyte	1.00548981
75	MP0001324_abnormal_eye_pigmentation	0.99935124
76	MP0001486_abnormal_startle_reflex	0.99822942
77	MP0001764_abnormal_homeostasis	0.96552075
78	MP0001485_abnormal_pinna_reflex	0.96229922
79	MP0000647_abnormal_sebaceous_gland	0.95185528
80	MP0000653_abnormal_sex_gland	0.92737739
81	MP0005195_abnormal_posterior_eye	0.91441827
82	MP0000383_abnormal_hair_follicle	0.91335569
83	MP0005395_other_phenotype	0.89689620
84	MP0003698_abnormal_male_reproductive	0.89524130
85	MP0002184_abnormal_innervation	0.89483151
86	MP0000778_abnormal_nervous_system	0.89288444
87	MP0004019_abnormal_vitamin_homeostasis	0.89003396
88	MP0005332_abnormal_amino_acid	0.88005127
89	MP0001145_abnormal_male_reproductive	0.84134525
90	MP0010386_abnormal_urinary_bladder	0.83001073
91	MP0003786_premature_aging	0.82948089
92	MP0001919_abnormal_reproductive_system	0.81928783
93	MP0002752_abnormal_somatic_nervous	0.80440704
94	MP0010678_abnormal_skin_adnexa	0.79176026
95	MP0006035_abnormal_mitochondrial_morpho	0.78850326
96	MP0003635_abnormal_synaptic_transmissio	0.78360628
97	MP0001970_abnormal_pain_threshold	0.78119081
98	MP0004270_analgesia	0.77940467
99	MP0002067_abnormal_sensory_capabilities	0.77625042
100	MP0005084_abnormal_gallbladder_morpholo	0.76191579

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.89039118
2	Pancreatic fibrosis (HP:0100732)	3.77360419
3	True hermaphroditism (HP:0010459)	3.57922582
4	Abnormality of midbrain morphology (HP:0002418)	3.55923023
5	Molar tooth sign on MRI (HP:0002419)	3.55923023
6	Medial flaring of the eyebrow (HP:0010747)	3.04618623
7	Nephronophthisis (HP:0000090)	2.96435853
8	Abnormality of the labia minora (HP:0012880)	2.89943890
9	Hypothermia (HP:0002045)	2.78172627
10	Gait imbalance (HP:0002141)	2.67774215
11	Colon cancer (HP:0003003)	2.67282093
12	Chronic hepatic failure (HP:0100626)	2.59161019
13	Lipid accumulation in hepatocytes (HP:0006561)	2.56166916
14	Abnormality of the renal cortex (HP:0011035)	2.53783464
15	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.53267599
16	Increased hepatocellular lipid droplets (HP:0006565)	2.52375986
17	Type II lissencephaly (HP:0007260)	2.51179423
18	Congenital primary aphakia (HP:0007707)	2.49491625
19	Abnormality of the renal medulla (HP:0100957)	2.49310561
20	Mitochondrial inheritance (HP:0001427)	2.44988339
21	Increased CSF lactate (HP:0002490)	2.42867714
22	Nephrogenic diabetes insipidus (HP:0009806)	2.40563037
23	Acute necrotizing encephalopathy (HP:0006965)	2.40408161
24	Polydipsia (HP:0001959)	2.38146551
25	Abnormal drinking behavior (HP:0030082)	2.38146551
26	Genital tract atresia (HP:0001827)	2.36204732
27	Cystic liver disease (HP:0006706)	2.34405493
28	Hepatic necrosis (HP:0002605)	2.32490381
29	Congenital stationary night blindness (HP:0007642)	2.30687598
30	Hypomagnesemia (HP:0002917)	2.28485816
31	Renal Fanconi syndrome (HP:0001994)	2.27000757
32	Hepatocellular necrosis (HP:0001404)	2.26422090
33	Pendular nystagmus (HP:0012043)	2.22978445
34	Vaginal atresia (HP:0000148)	2.22855794
35	Progressive macrocephaly (HP:0004481)	2.21581814
36	Abnormal biliary tract physiology (HP:0012439)	2.19052108
37	Bile duct proliferation (HP:0001408)	2.19052108
38	Postaxial foot polydactyly (HP:0001830)	2.17219148
39	Neoplasm of the adrenal cortex (HP:0100641)	2.16232408
40	Sclerocornea (HP:0000647)	2.15402177
41	Renal cortical cysts (HP:0000803)	2.12831676
42	Acute encephalopathy (HP:0006846)	2.12791872
43	Anencephaly (HP:0002323)	2.12621889
44	Methylmalonic acidemia (HP:0002912)	2.07665405
45	Oligodactyly (hands) (HP:0001180)	2.04148160
46	Large for gestational age (HP:0001520)	2.03654233
47	Supernumerary spleens (HP:0009799)	2.03280094
48	Male pseudohermaphroditism (HP:0000037)	2.03072841
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.00407222
50	Meckel diverticulum (HP:0002245)	1.99742742
51	Hypoglycemic coma (HP:0001325)	1.98927540
52	Abnormality of the ileum (HP:0001549)	1.98677356
53	Tubular atrophy (HP:0000092)	1.98121419
54	Occipital encephalocele (HP:0002085)	1.97229265
55	Abnormal mitochondria in muscle tissue (HP:0008316)	1.96970049
56	Hyperglycinemia (HP:0002154)	1.95636048
57	Preaxial hand polydactyly (HP:0001177)	1.93749375
58	Pancreatic islet-cell hyperplasia (HP:0004510)	1.92596637
59	Intestinal atresia (HP:0011100)	1.91703826
60	Congenital hepatic fibrosis (HP:0002612)	1.90979894
61	Attenuation of retinal blood vessels (HP:0007843)	1.90607132
62	Thyroid-stimulating hormone excess (HP:0002925)	1.88836284
63	Hyperinsulinemic hypoglycemia (HP:0000825)	1.87947167
64	Lissencephaly (HP:0001339)	1.86748133
65	Gaze-evoked nystagmus (HP:0000640)	1.86278715
66	Postaxial hand polydactyly (HP:0001162)	1.85619900
67	Abnormality of chromosome stability (HP:0003220)	1.85150281
68	Hyperglycinuria (HP:0003108)	1.83127057
69	Ketoacidosis (HP:0001993)	1.82269096
70	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81362714
71	Dandy-Walker malformation (HP:0001305)	1.80617920
72	Methylmalonic aciduria (HP:0012120)	1.80361798
73	Abnormality of the pons (HP:0007361)	1.77929954
74	Abnormality of endocrine pancreas physiology (HP:0012093)	1.77385052
75	Abnormality of the pancreatic islet cells (HP:0006476)	1.77385052
76	Hyperventilation (HP:0002883)	1.77132517
77	Chromsome breakage (HP:0040012)	1.77018059
78	Poor coordination (HP:0002370)	1.76654008
79	Inability to walk (HP:0002540)	1.75989879
80	Polyuria (HP:0000103)	1.75879398
81	Abnormality of urine glucose concentration (HP:0011016)	1.75756841
82	Glycosuria (HP:0003076)	1.75756841
83	3-Methylglutaconic aciduria (HP:0003535)	1.75517306
84	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.75321083
85	Increased serum lactate (HP:0002151)	1.74976600
86	Hypoplasia of the pons (HP:0012110)	1.72887452
87	Hypoglycemic seizures (HP:0002173)	1.70413293
88	Optic disc pallor (HP:0000543)	1.69878850
89	Short tibia (HP:0005736)	1.69079206
90	Triphalangeal thumb (HP:0001199)	1.68377226
91	Sloping forehead (HP:0000340)	1.66680971
92	Absent/shortened dynein arms (HP:0200106)	1.66465572
93	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.66465572
94	Abnormality of serine family amino acid metabolism (HP:0010894)	1.66368870
95	Abnormality of glycine metabolism (HP:0010895)	1.66368870
96	Cerebellar dysplasia (HP:0007033)	1.66142671
97	Abnormality of methionine metabolism (HP:0010901)	1.65550691
98	Decreased central vision (HP:0007663)	1.64834668
99	Median cleft lip (HP:0000161)	1.63903982
100	Optic nerve hypoplasia (HP:0000609)	1.63655012

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.28752749
2	WNK3	3.40075850
3	ZAK	3.09938974
4	MAP4K2	3.00695846
5	TRIM28	2.87850192
6	BMPR1B	2.37594497
7	TNIK	2.17429633
8	TSSK6	2.15638354
9	TLK1	2.14089020
10	VRK2	2.07200977
11	ADRBK2	2.03668069
12	STK16	2.00598333
13	NUAK1	1.99234876
14	MAP3K4	1.72493732
15	VRK1	1.67277976
16	PLK3	1.66688949
17	BUB1	1.64507602
18	MAP2K7	1.60206143
19	MAPK13	1.57951198
20	BRSK2	1.54917474
21	GRK1	1.51768945
22	MST4	1.50933050
23	BCR	1.48868702
24	WNK4	1.46049538
25	FGFR2	1.45238799
26	CSNK1G1	1.39750470
27	DYRK2	1.38793970
28	TAF1	1.36806044
29	SRPK1	1.36766042
30	PINK1	1.35395765
31	EIF2AK3	1.34679986
32	OXSR1	1.31609195
33	CASK	1.27793442
34	CSNK1G3	1.23839670
35	MKNK2	1.22994692
36	ACVR1B	1.20933856
37	STK39	1.18604497
38	TAOK3	1.18443646
39	MAP2K6	1.17111593
40	CSNK1G2	1.16064374
41	CDC7	1.13261534
42	PAK3	1.07342200
43	TTK	1.07323067
44	MARK1	1.06829673
45	NME1	1.05064222
46	MKNK1	1.02587867
47	CSNK1A1L	1.00419974
48	PLK1	1.00232790
49	PHKG1	0.99644173
50	PHKG2	0.99644173
51	BCKDK	0.97325556
52	PRKCG	0.96101901
53	PASK	0.96047798
54	PRKCI	0.87399332
55	STK38L	0.86639631
56	NTRK3	0.85316784
57	INSRR	0.84758914
58	PLK2	0.82878244
59	MAPKAPK5	0.80553967
60	STK3	0.79681665
61	SIK2	0.79478750
62	PRKCE	0.78415544
63	FLT3	0.77659212
64	EIF2AK1	0.76820088
65	DAPK2	0.73206830
66	ERBB3	0.72761348
67	ATR	0.71083073
68	EPHA4	0.69613828
69	EIF2AK2	0.67595077
70	PNCK	0.67545825
71	CAMKK2	0.65159934
72	MUSK	0.64682311
73	MAPK15	0.64591401
74	MAPKAPK3	0.60812572
75	BRSK1	0.58798749
76	ATM	0.57343933
77	STK24	0.55970552
78	NLK	0.55769315
79	PRKD3	0.55720526
80	ADRBK1	0.53192569
81	CSNK1A1	0.52098047
82	MINK1	0.49129889
83	DYRK3	0.47634878
84	CHEK2	0.46236999
85	STK4	0.46031603
86	MAP2K4	0.44859999
87	STK11	0.44048112
88	PLK4	0.43633601
89	CSNK1E	0.43393402
90	TGFBR1	0.41828844
91	CAMK2A	0.41449107
92	WEE1	0.41198995
93	DAPK1	0.40736272
94	CSNK1D	0.38312388
95	MAP3K5	0.36848208
96	PRKCZ	0.35883239
97	PIK3CA	0.35736670
98	CSNK2A1	0.34980355
99	SIK3	0.34817708
100	NEK6	0.34359697

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.34323851
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.62457209
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.49819256
4	Butanoate metabolism_Homo sapiens_hsa00650	2.47980559
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47351567
6	Basal transcription factors_Homo sapiens_hsa03022	2.42790255
7	Protein export_Homo sapiens_hsa03060	2.42041887
8	Homologous recombination_Homo sapiens_hsa03440	2.24215271
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.23573770
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.14370308
11	Phototransduction_Homo sapiens_hsa04744	2.06837744
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00379823
13	Parkinsons disease_Homo sapiens_hsa05012	1.96922664
14	Proteasome_Homo sapiens_hsa03050	1.81873205
15	RNA polymerase_Homo sapiens_hsa03020	1.78615577
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.78302844
17	Mismatch repair_Homo sapiens_hsa03430	1.76822457
18	Nicotine addiction_Homo sapiens_hsa05033	1.69301169
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68859879
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.67977313
21	RNA degradation_Homo sapiens_hsa03018	1.66371088
22	Propanoate metabolism_Homo sapiens_hsa00640	1.64601029
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62247570
24	Caffeine metabolism_Homo sapiens_hsa00232	1.54291538
25	Huntingtons disease_Homo sapiens_hsa05016	1.47952932
26	Fatty acid elongation_Homo sapiens_hsa00062	1.44387892
27	One carbon pool by folate_Homo sapiens_hsa00670	1.43953980
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42761018
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.42536594
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.33850843
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31871420
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27292646
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.22044580
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.21794050
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20439816
36	RNA transport_Homo sapiens_hsa03013	1.18369219
37	Peroxisome_Homo sapiens_hsa04146	1.14895775
38	Alzheimers disease_Homo sapiens_hsa05010	1.14294151
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13857685
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13179567
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11332830
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10547916
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.08669753
44	Taste transduction_Homo sapiens_hsa04742	1.08369197
45	Folate biosynthesis_Homo sapiens_hsa00790	1.07822856
46	Base excision repair_Homo sapiens_hsa03410	1.06086191
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.05755634
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.02937029
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02189203
50	Regulation of autophagy_Homo sapiens_hsa04140	0.97680625
51	Ribosome_Homo sapiens_hsa03010	0.96820021
52	DNA replication_Homo sapiens_hsa03030	0.93804121
53	Purine metabolism_Homo sapiens_hsa00230	0.91905917
54	Insulin secretion_Homo sapiens_hsa04911	0.90830747
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88656271
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87745468
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85526496
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.85509704
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85177078
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84694442
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84238717
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83743538
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.82591029
64	Morphine addiction_Homo sapiens_hsa05032	0.80776040
65	Metabolic pathways_Homo sapiens_hsa01100	0.79526631
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78790364
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78353884
68	Sulfur metabolism_Homo sapiens_hsa00920	0.78254855
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76409380
70	Olfactory transduction_Homo sapiens_hsa04740	0.75516826
71	GABAergic synapse_Homo sapiens_hsa04727	0.75390926
72	Glutathione metabolism_Homo sapiens_hsa00480	0.74752109
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73829030
74	Retinol metabolism_Homo sapiens_hsa00830	0.72443045
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71387062
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66394509
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64749066
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64719161
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.63634388
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.63149828
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62462273
82	Sulfur relay system_Homo sapiens_hsa04122	0.60267126
83	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59536250
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.58272319
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58003528
86	Spliceosome_Homo sapiens_hsa03040	0.57436990
87	ABC transporters_Homo sapiens_hsa02010	0.57132515
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56988455
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55991490
90	Serotonergic synapse_Homo sapiens_hsa04726	0.55615620
91	Fatty acid degradation_Homo sapiens_hsa00071	0.52492746
92	Cell cycle_Homo sapiens_hsa04110	0.52363322
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49134482
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.48057249
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47490111
96	Circadian entrainment_Homo sapiens_hsa04713	0.47026342
97	Histidine metabolism_Homo sapiens_hsa00340	0.46703857
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.44185305
99	Oocyte meiosis_Homo sapiens_hsa04114	0.44118690
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43118893

C2ORF15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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