C2ORF16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.52593367
2acrosome reaction (GO:0007340)8.25830711
3plasma membrane fusion (GO:0045026)8.09216396
4chromosome condensation (GO:0030261)7.72894748
5DNA packaging (GO:0006323)7.47677720
6binding of sperm to zona pellucida (GO:0007339)6.89052344
7sperm-egg recognition (GO:0035036)6.71714743
8sperm capacitation (GO:0048240)6.26825160
9spermatid development (GO:0007286)6.16352491
10microtubule depolymerization (GO:0007019)6.14079284
11spermatid nucleus differentiation (GO:0007289)6.11881974
12rRNA methylation (GO:0031167)5.95465925
13multicellular organism reproduction (GO:0032504)5.66660433
14cell-cell recognition (GO:0009988)5.48897282
15centriole replication (GO:0007099)5.43336913
16spermatogenesis (GO:0007283)5.33036793
17male gamete generation (GO:0048232)5.31635946
18reproduction (GO:0000003)5.19741863
19microtubule polymerization or depolymerization (GO:0031109)5.19294289
20single strand break repair (GO:0000012)5.17416474
21microtubule severing (GO:0051013)5.15383257
22protein targeting to Golgi (GO:0000042)5.08532050
23gamete generation (GO:0007276)4.89131573
24establishment of protein localization to Golgi (GO:0072600)4.86798666
25phosphatidylethanolamine biosynthetic process (GO:0006646)4.83537127
26rRNA modification (GO:0000154)4.79071849
27sexual reproduction (GO:0019953)4.75931021
28protein polyglutamylation (GO:0018095)4.75258520
29centriole assembly (GO:0098534)4.71191872
30retrograde transport, vesicle recycling within Golgi (GO:0000301)4.69579138
31regulation of centriole replication (GO:0046599)4.64591743
32negative regulation of inclusion body assembly (GO:0090084)4.63888928
33nuclear pore complex assembly (GO:0051292)4.58829673
34axonemal dynein complex assembly (GO:0070286)4.48085633
35phosphatidylethanolamine metabolic process (GO:0046337)4.46414249
36positive regulation of action potential (GO:0045760)4.44931191
37response to pheromone (GO:0019236)4.40358335
38regulation of acrosome reaction (GO:0060046)4.27033179
39intra-Golgi vesicle-mediated transport (GO:0006891)4.22186695
40calcium ion-dependent exocytosis (GO:0017156)4.17377388
41nucleus organization (GO:0006997)4.10454804
42regulation of Rab GTPase activity (GO:0032313)4.09557104
43positive regulation of Rab GTPase activity (GO:0032851)4.09557104
44mitotic sister chromatid segregation (GO:0000070)4.07784016
45piRNA metabolic process (GO:0034587)4.01865521
46DNA methylation involved in gamete generation (GO:0043046)3.99706910
47cilium or flagellum-dependent cell motility (GO:0001539)3.98106779
48multicellular organismal reproductive process (GO:0048609)3.96763318
49fertilization (GO:0009566)3.94013656
50single fertilization (GO:0007338)3.93109857
51germ cell development (GO:0007281)3.84964114
52cellular process involved in reproduction in multicellular organism (GO:0022412)3.81809261
53glomerular visceral epithelial cell development (GO:0072015)3.76842548
54pore complex assembly (GO:0046931)3.61703874
55sister chromatid segregation (GO:0000819)3.54094892
56protein localization to Golgi apparatus (GO:0034067)3.47022294
57glomerular epithelial cell development (GO:0072310)3.46079605
58nuclear pore organization (GO:0006999)3.44217053
59musculoskeletal movement (GO:0050881)3.43994670
60multicellular organismal movement (GO:0050879)3.43994670
61motile cilium assembly (GO:0044458)3.39301271
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.32903116
63L-phenylalanine catabolic process (GO:0006559)3.32903116
64regulation of cilium movement (GO:0003352)3.31504886
65negative regulation of autophagy (GO:0010507)3.28308899
66chromatin silencing (GO:0006342)3.26785287
67nucleosome disassembly (GO:0006337)3.23639965
68protein-DNA complex disassembly (GO:0032986)3.23639965
69male meiosis I (GO:0007141)3.22960542
70embryonic body morphogenesis (GO:0010172)3.17325083
71cellular zinc ion homeostasis (GO:0006882)3.16670890
72cytoskeletal anchoring at plasma membrane (GO:0007016)3.13204715
73L-phenylalanine metabolic process (GO:0006558)3.11709883
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.11709883
75negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.07602407
76response to acidic pH (GO:0010447)3.00160809
77male meiosis (GO:0007140)2.99807715
78histone H3-K9 demethylation (GO:0033169)2.97703300
79epithelial cilium movement (GO:0003351)2.96691617
80seminiferous tubule development (GO:0072520)2.93658992
81gene silencing (GO:0016458)2.93440449
82meiotic cell cycle (GO:0051321)2.90634713
83polarized epithelial cell differentiation (GO:0030859)2.89232250
84organic cation transport (GO:0015695)2.88235011
85DNA conformation change (GO:0071103)2.84174992
86cell wall macromolecule catabolic process (GO:0016998)2.81598976
87body morphogenesis (GO:0010171)2.79569217
88polyamine biosynthetic process (GO:0006596)2.79086376
89regulation of inclusion body assembly (GO:0090083)2.78152146
90regulation of histone H3-K9 methylation (GO:0051570)2.76189290
91negative regulation of histone methylation (GO:0031061)2.73754263
92microtubule nucleation (GO:0007020)2.71932594
93cell wall macromolecule metabolic process (GO:0044036)2.71802557
94peptidyl-threonine dephosphorylation (GO:0035970)2.69553367
95cellular ketone body metabolic process (GO:0046950)2.67571214
96regulation of transcription involved in cell fate commitment (GO:0060850)2.64972433
97mitochondrial fission (GO:0000266)2.64472698
98regulation of retinoic acid receptor signaling pathway (GO:0048385)2.64450804
99negative regulation of Rho protein signal transduction (GO:0035024)2.63902446
100fusion of sperm to egg plasma membrane (GO:0007342)10.8436867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.23087436
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.85969841
3E2F7_22180533_ChIP-Seq_HELA_Human2.98537285
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89522590
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.66566987
6EZH2_22144423_ChIP-Seq_EOC_Human2.47008443
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.24651054
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19485303
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16283530
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15393655
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.04921653
12ARNT_22903824_ChIP-Seq_MCF-7_Human2.04020760
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94880803
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94880803
15PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.93084338
16ERA_21632823_ChIP-Seq_H3396_Human1.87721355
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84492019
18RAC3_21632823_ChIP-Seq_H3396_Human1.83271420
19ER_23166858_ChIP-Seq_MCF-7_Human1.82774176
20CBP_20019798_ChIP-Seq_JUKART_Human1.78163523
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78163523
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77439258
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75511961
24TDRD3_21172665_ChIP-Seq_MCF-7_Human1.75222026
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74524332
26AR_21572438_ChIP-Seq_LNCaP_Human1.67013527
27FUS_26573619_Chip-Seq_HEK293_Human1.66431891
28SMC4_20622854_ChIP-Seq_HELA_Human1.63303933
29WDR5_24793694_ChIP-Seq_LNCAP_Human1.62109519
30PKCTHETA_26484144_Chip-Seq_BREAST_Human1.60720509
31CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60102262
32SMAD4_21741376_ChIP-Seq_EPCs_Human1.58360385
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.56549672
34CJUN_26792858_Chip-Seq_BT549_Human1.52662789
35YY1_22570637_ChIP-Seq_MALME-3M_Human1.52353420
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.51561365
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50998516
38TP53_18474530_ChIP-ChIP_U2OS_Human1.48760402
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48441628
40AHR_22903824_ChIP-Seq_MCF-7_Human1.48415354
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.47450912
42CBX2_22325352_ChIP-Seq_293T-Rex_Human1.47381802
43TBL1_22424771_ChIP-Seq_293T_Human1.43364814
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.43228804
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40281990
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39676044
47RUNX1_26923725_Chip-Seq_HPCs_Mouse1.39343562
48* STAT3_23295773_ChIP-Seq_U87_Human1.37373187
49ETV1_20927104_ChIP-Seq_GIST48_Human1.37043959
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35983672
51AR_25329375_ChIP-Seq_VCAP_Human1.33589001
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33323330
53DROSHA_22980978_ChIP-Seq_HELA_Human1.31779017
54TP63_22573176_ChIP-Seq_HFKS_Human1.31520066
55CTCF_27219007_Chip-Seq_Bcells_Human1.28394990
56NFYB_21822215_ChIP-Seq_K562_Human1.26767342
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24735464
58P68_20966046_ChIP-Seq_HELA_Human1.24485620
59MYC_19829295_ChIP-Seq_ESCs_Human1.23129307
60RBPJ_21746931_ChIP-Seq_IB4_Human1.22983139
61E2F1_20622854_ChIP-Seq_HELA_Human1.21994456
62BCOR_27268052_Chip-Seq_Bcells_Human1.21916359
63TAF2_19829295_ChIP-Seq_ESCs_Human1.20042413
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.18131279
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.17512017
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.16823236
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16669353
68NANOG_20526341_ChIP-Seq_ESCs_Human1.16064415
69ERG_20517297_ChIP-Seq_VCAP_Human1.15967661
70OCT4_20526341_ChIP-Seq_ESCs_Human1.15420878
71PHF8_20622854_ChIP-Seq_HELA_Human1.15367989
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.14854814
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.13980671
74P300_27268052_Chip-Seq_Bcells_Human1.13769849
75KLF5_25053715_ChIP-Seq_YYC3_Human1.13602528
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12791686
77PHF8_20622853_ChIP-Seq_HELA_Human1.11536973
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.11246643
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09822285
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.07872995
81LXR_22292898_ChIP-Seq_THP-1_Human1.07797877
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07665235
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07469130
84NFYA_21822215_ChIP-Seq_K562_Human1.06928997
85P300_19829295_ChIP-Seq_ESCs_Human1.05817434
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05289689
87CEBPB_22108803_ChIP-Seq_LS180_Human1.03592100
88RUNX2_22187159_ChIP-Seq_PCA_Human1.03005133
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.02735024
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02387584
91* CTCF_20526341_ChIP-Seq_ESCs_Human1.01588610
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00291804
93SA1_27219007_Chip-Seq_Bcells_Human1.00204718
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98511784
95OCT1_27270436_Chip-Seq_PROSTATE_Human0.98259533
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97971190
97SOX2_22085726_ChIP-Seq_NPCs_Mouse0.97458379
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96974106
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96901989
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96629528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.58435273
2MP0003698_abnormal_male_reproductive4.08788284
3MP0001929_abnormal_gametogenesis3.73465338
4MP0005377_hearing/vestibular/ear_phenot3.65112995
5MP0003878_abnormal_ear_physiology3.65112995
6MP0008057_abnormal_DNA_replication3.48874273
7MP0005670_abnormal_white_adipose3.10511206
8MP0005451_abnormal_body_composition2.88281117
9MP0001348_abnormal_lacrimal_gland2.65450043
10MP0008007_abnormal_cellular_replicative2.57512425
11MP0002161_abnormal_fertility/fecundity2.36957187
12MP0004233_abnormal_muscle_weight2.32761086
13MP0003718_maternal_effect2.29061785
14MP0003693_abnormal_embryo_hatching2.27622432
15MP0002210_abnormal_sex_determination2.14793920
16MP0009053_abnormal_anal_canal2.06845927
17MP0000678_abnormal_parathyroid_gland2.06688592
18MP0002282_abnormal_trachea_morphology2.05179752
19MP0005623_abnormal_meninges_morphology1.97455135
20MP0000534_abnormal_ureter_morphology1.96288989
21MP0010307_abnormal_tumor_latency1.86334851
22MP0001145_abnormal_male_reproductive1.77952790
23MP0000653_abnormal_sex_gland1.66812036
24MP0005408_hypopigmentation1.59840128
25MP0002160_abnormal_reproductive_system1.59259501
26MP0003077_abnormal_cell_cycle1.49905824
27MP0002653_abnormal_ependyma_morphology1.38682851
28MP0002234_abnormal_pharynx_morphology1.38672514
29MP0003011_delayed_dark_adaptation1.37073385
30MP0003950_abnormal_plasma_membrane1.34495767
31MP0002822_catalepsy1.28985666
32MP0000467_abnormal_esophagus_morphology1.19905748
33MP0005365_abnormal_bile_salt1.18452926
34MP0002249_abnormal_larynx_morphology1.17236828
35MP0010094_abnormal_chromosome_stability1.14764315
36MP0000569_abnormal_digit_pigmentation1.13226884
37MP0003943_abnormal_hepatobiliary_system1.11999728
38MP0008438_abnormal_cutaneous_collagen1.11826642
39MP0005395_other_phenotype1.11252838
40MP0002132_abnormal_respiratory_system0.99553163
41MP0005409_darkened_coat_color0.98076243
42MP0004957_abnormal_blastocyst_morpholog0.97653359
43MP0002009_preneoplasia0.95574597
44MP0002089_abnormal_postnatal_growth/wei0.95335207
45MP0005248_abnormal_Harderian_gland0.93386782
46MP0002127_abnormal_cardiovascular_syste0.93378950
47MP0001666_abnormal_nutrient_absorption0.92322683
48MP0001881_abnormal_mammary_gland0.92312777
49MP0001486_abnormal_startle_reflex0.89610298
50MP0009697_abnormal_copulation0.87942871
51MP0005083_abnormal_biliary_tract0.87412981
52MP0003936_abnormal_reproductive_system0.86940039
53MP0004742_abnormal_vestibular_system0.86743998
54MP0003942_abnormal_urinary_system0.84640079
55MP0003879_abnormal_hair_cell0.83323937
56MP0000371_diluted_coat_color0.80070981
57MP0005647_abnormal_sex_gland0.77294332
58MP0001340_abnormal_eyelid_morphology0.76418563
59MP0010368_abnormal_lymphatic_system0.73717435
60MP0003699_abnormal_female_reproductive0.73461623
61MP0005666_abnormal_adipose_tissue0.72688990
62MP0002092_abnormal_eye_morphology0.72196332
63MP0003959_abnormal_lean_body0.70856153
64MP0001485_abnormal_pinna_reflex0.68655806
65MP0003705_abnormal_hypodermis_morpholog0.68584619
66MP0005551_abnormal_eye_electrophysiolog0.66029796
67MP0003868_abnormal_feces_composition0.63968134
68MP0005310_abnormal_salivary_gland0.63387141
69MP0003119_abnormal_digestive_system0.63176344
70MP0004808_abnormal_hematopoietic_stem0.63071358
71MP0005391_vision/eye_phenotype0.62734773
72MP0005085_abnormal_gallbladder_physiolo0.62406345
73MP0008877_abnormal_DNA_methylation0.62100165
74MP0005360_urolithiasis0.61184693
75MP0003646_muscle_fatigue0.60784606
76MP0000015_abnormal_ear_pigmentation0.59764357
77MP0005389_reproductive_system_phenotype0.58543517
78MP0002184_abnormal_innervation0.57854317
79MP0003861_abnormal_nervous_system0.56945268
80MP0000955_abnormal_spinal_cord0.56215057
81MP0002697_abnormal_eye_size0.55994164
82MP0005423_abnormal_somatic_nervous0.54840575
83MP0002229_neurodegeneration0.52987337
84MP0002557_abnormal_social/conspecific_i0.52025324
85MP0003115_abnormal_respiratory_system0.51599326
86MP0003385_abnormal_body_wall0.51413314
87MP0002085_abnormal_embryonic_tissue0.51196616
88MP0001963_abnormal_hearing_physiology0.51146321
89MP0005167_abnormal_blood-brain_barrier0.50724456
90MP0005332_abnormal_amino_acid0.50546068
91MP0010329_abnormal_lipoprotein_level0.49492602
92MP0004134_abnormal_chest_morphology0.49458475
93MP0005380_embryogenesis_phenotype0.48819284
94MP0001672_abnormal_embryogenesis/_devel0.48819284
95MP0005253_abnormal_eye_physiology0.48434933
96MP0002932_abnormal_joint_morphology0.47982644
97MP0002080_prenatal_lethality0.47942241
98MP0003935_abnormal_craniofacial_develop0.47805844
99MP0001873_stomach_inflammation0.47413023
100MP0009115_abnormal_fat_cell0.46797916

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.39865119
2Tubulointerstitial nephritis (HP:0001970)4.30018876
3Chronic hepatic failure (HP:0100626)4.01216889
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.99888389
5Absent/shortened dynein arms (HP:0200106)3.99888389
6Hyperkalemia (HP:0002153)3.82274712
7Horizontal nystagmus (HP:0000666)3.74138894
8Aplasia/Hypoplasia of the earlobes (HP:0009906)3.58163642
9Hypophosphatemic rickets (HP:0004912)3.53469536
10Renovascular hypertension (HP:0100817)3.53089642
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.47101156
12Male infertility (HP:0003251)3.31407644
13Cone-rod dystrophy (HP:0000548)3.14424382
14Abnormality of macular pigmentation (HP:0008002)3.12435282
15Bony spicule pigmentary retinopathy (HP:0007737)3.00965836
16Microglossia (HP:0000171)2.94166640
17Asymmetric septal hypertrophy (HP:0001670)2.91759620
18Hypoplastic ischia (HP:0003175)2.88773821
19Infertility (HP:0000789)2.85797818
20Osteomalacia (HP:0002749)2.83834911
21Pendular nystagmus (HP:0012043)2.81416615
22Vertebral clefting (HP:0008428)2.77868035
23Attenuation of retinal blood vessels (HP:0007843)2.77659535
24Enlarged epiphyses (HP:0010580)2.77047706
25Flattened epiphyses (HP:0003071)2.74622924
26Abnormality of the ischium (HP:0003174)2.73132686
27Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.65880082
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65061300
29Abnormal respiratory motile cilium physiology (HP:0012261)2.64344792
30Failure to thrive in infancy (HP:0001531)2.63677257
31Azoospermia (HP:0000027)2.63128498
32Abnormal ciliary motility (HP:0012262)2.62865428
33Facial shape deformation (HP:0011334)2.57865716
34Potter facies (HP:0002009)2.57865716
35Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.52681426
36Hypoplastic pelvis (HP:0008839)2.46836811
37Short middle phalanx of the 5th finger (HP:0004220)2.46278663
38Termporal pattern (HP:0011008)2.46078166
39Insidious onset (HP:0003587)2.46078166
40Sandal gap (HP:0001852)2.44534815
41Upper limb muscle weakness (HP:0003484)2.42658115
42Depressed nasal tip (HP:0000437)2.41579870
43Abnormal finger flexion creases (HP:0006143)2.41202099
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39677649
45Ileus (HP:0002595)2.37003052
46Progressive sensorineural hearing impairment (HP:0000408)2.36402432
47Menstrual irregularities (HP:0000858)2.35848872
48Impulsivity (HP:0100710)2.34104745
49Bell-shaped thorax (HP:0001591)2.29648968
50Abnormal respiratory motile cilium morphology (HP:0005938)2.29480361
51Abnormal respiratory epithelium morphology (HP:0012253)2.29480361
52Truncal obesity (HP:0001956)2.23714196
53Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.23085640
54Short 5th finger (HP:0009237)2.22926222
55Resting tremor (HP:0002322)2.22388574
56Abnormality of the pubic bones (HP:0003172)2.21948660
57Hypoalphalipoproteinemia (HP:0003233)2.21534661
58Nasal polyposis (HP:0100582)2.21238894
59Epiphyseal dysplasia (HP:0002656)2.19663318
60Abnormal spermatogenesis (HP:0008669)2.17110393
61Convex nasal ridge (HP:0000444)2.13330606
62Stage 5 chronic kidney disease (HP:0003774)2.12623787
63Chronic bronchitis (HP:0004469)2.11465597
64Generalized aminoaciduria (HP:0002909)2.09940691
65Glomerulosclerosis (HP:0000096)2.08226333
66Abnormality of dentin (HP:0010299)2.00959248
67Amelogenesis imperfecta (HP:0000705)2.00589047
68Portal hypertension (HP:0001409)1.99218387
69Pterygium (HP:0001059)1.96049887
70Ectopic kidney (HP:0000086)1.95891989
71Subcapsular cataract (HP:0000523)1.93398905
72Fatigable weakness (HP:0003473)1.93277817
73Abnormality of the neuromuscular junction (HP:0003398)1.93277817
74Neonatal short-limb short stature (HP:0008921)1.93137742
75Abnormality of the acetabulum (HP:0003170)1.89708968
76Abnormality of the epiphyses of the hand (HP:0005924)1.86926403
77Hand muscle atrophy (HP:0009130)1.86890350
78Rhizomelia (HP:0008905)1.85284694
79Hypoparathyroidism (HP:0000829)1.84950547
80Rickets (HP:0002748)1.84794439
81Abnormality of the hepatic vasculature (HP:0006707)1.84586880
82Obsessive-compulsive behavior (HP:0000722)1.82288671
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82031440
84Absent epiphyses (HP:0010577)1.82031440
85Lip pit (HP:0100267)1.80889106
86Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.80875754
87Deep philtrum (HP:0002002)1.76947686
88Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76579751
89Ankyloglossia (HP:0010296)1.75915945
90Deep venous thrombosis (HP:0002625)1.75169262
91Abnormality of the aortic arch (HP:0012303)1.74793630
92Focal segmental glomerulosclerosis (HP:0000097)1.74681922
93Underdeveloped nasal alae (HP:0000430)1.74493733
94Abnormality of the nasal mucosa (HP:0000433)1.73690762
95Tubulointerstitial abnormality (HP:0001969)1.71570353
96Conjugated hyperbilirubinemia (HP:0002908)1.71151906
97Renal duplication (HP:0000075)1.70952833
98Narrow face (HP:0000275)1.68570840
99Esophageal varix (HP:0002040)1.68477598
100Small epiphyses (HP:0010585)1.66971782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.33847593
2MUSK5.16834851
3PNCK4.39220578
4DDR23.46863238
5BRD43.16058246
6TESK13.02177910
7CAMK1G3.01574986
8MET2.45177014
9PLK22.40541349
10SIK22.37579184
11CDK122.35052910
12INSRR2.33515819
13MST1R2.31810148
14MAP3K22.16004561
15TYRO31.93620852
16MAP3K91.85955366
17KSR21.81441446
18LATS21.69972785
19PIK3CG1.69665672
20STK381.54178381
21BRSK21.46954755
22CDK71.46161424
23ICK1.39871748
24STK38L1.30095908
25ARAF1.29958812
26CAMK1D1.28594331
27DYRK31.21848829
28AKT31.19292119
29RAF11.16983682
30PDPK11.05698014
31TRIB31.03413143
32BRAF1.02874570
33PTK2B1.02110258
34WNK10.99823282
35PDK10.99142333
36IRAK30.96774498
37LATS10.90696298
38FER0.90559245
39EEF2K0.89966959
40MAP3K40.89092711
41MAPK150.86042908
42FLT30.84538980
43MAP3K30.84117751
44EPHA20.82078316
45MTOR0.80757853
46PDGFRA0.80389800
47RET0.79054406
48PIM20.77730792
49NTRK30.75511098
50NEK60.74220006
51PKN20.72983832
52PASK0.65084034
53PRKD30.64670926
54PRKCI0.61751519
55PRKAA20.59232170
56BRSK10.59230646
57MAP2K10.57733731
58CDK10.56491302
59CHEK20.55361822
60EPHA30.53507804
61NEK90.52395132
62CHEK10.51887982
63NTRK10.51450331
64MARK30.49427468
65PTK20.48852019
66MAP3K80.47609521
67CDK20.44947719
68BCR0.41803606
69SRPK10.41258644
70KSR10.40305977
71TTK0.39958534
72FGFR40.39860322
73PDGFRB0.38723177
74ATR0.38047640
75MAPK10.37355642
76PTK60.36184181
77RPS6KA20.35763620
78GSK3B0.35180952
79NEK20.33713301
80MAP4K20.33687972
81MAPK110.33683812
82GSK3A0.33439581
83EIF2AK30.33348512
84NME10.32940216
85PAK20.32791954
86BMX0.32780623
87PRKAA10.32592758
88DYRK1B0.32425304
89ZAK0.31447590
90MAPK140.28430396
91PLK10.27438221
92PAK40.27160208
93CDK30.26785308
94RPS6KA10.26779999
95PRKG20.26650786
96AURKA0.26604491
97FGFR10.26022744
98MAP2K20.24918221
99MAP2K70.24343656
100LMTK20.24318322

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.71625763
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.42443011
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32424921
4Fatty acid metabolism_Homo sapiens_hsa012123.12676935
5Selenocompound metabolism_Homo sapiens_hsa004502.62342226
6Vitamin B6 metabolism_Homo sapiens_hsa007502.51011096
7RNA transport_Homo sapiens_hsa030132.15082456
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12499502
9Butanoate metabolism_Homo sapiens_hsa006502.06084189
10N-Glycan biosynthesis_Homo sapiens_hsa005102.04443816
11Fatty acid elongation_Homo sapiens_hsa000621.94636011
12Fatty acid degradation_Homo sapiens_hsa000711.88235333
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83779310
14Lysine degradation_Homo sapiens_hsa003101.76740644
15Olfactory transduction_Homo sapiens_hsa047401.74524701
16Steroid biosynthesis_Homo sapiens_hsa001001.49525177
17Oocyte meiosis_Homo sapiens_hsa041141.39736630
18Cell cycle_Homo sapiens_hsa041101.38838635
19PPAR signaling pathway_Homo sapiens_hsa033201.31155182
20ECM-receptor interaction_Homo sapiens_hsa045121.29515561
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28477407
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23963602
23Complement and coagulation cascades_Homo sapiens_hsa046101.21809224
24Type II diabetes mellitus_Homo sapiens_hsa049301.20751178
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18165475
26Dorso-ventral axis formation_Homo sapiens_hsa043201.11600933
27Phenylalanine metabolism_Homo sapiens_hsa003601.10489137
28Tyrosine metabolism_Homo sapiens_hsa003501.07079587
29Taste transduction_Homo sapiens_hsa047421.04846275
30Glycerophospholipid metabolism_Homo sapiens_hsa005640.95744231
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92662029
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92047614
33Prostate cancer_Homo sapiens_hsa052150.91811923
34Arginine and proline metabolism_Homo sapiens_hsa003300.91156130
35ABC transporters_Homo sapiens_hsa020100.90829560
36Adherens junction_Homo sapiens_hsa045200.90247589
37Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90113988
38Viral carcinogenesis_Homo sapiens_hsa052030.88700102
39Basal transcription factors_Homo sapiens_hsa030220.88574641
40Small cell lung cancer_Homo sapiens_hsa052220.87438548
41Adipocytokine signaling pathway_Homo sapiens_hsa049200.87305362
42Inositol phosphate metabolism_Homo sapiens_hsa005620.86922046
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.86411738
44Protein digestion and absorption_Homo sapiens_hsa049740.84107847
45Biosynthesis of amino acids_Homo sapiens_hsa012300.79146284
46MicroRNAs in cancer_Homo sapiens_hsa052060.79082282
47Non-small cell lung cancer_Homo sapiens_hsa052230.78010096
48Focal adhesion_Homo sapiens_hsa045100.77616318
49Bile secretion_Homo sapiens_hsa049760.77079094
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76722924
51Fat digestion and absorption_Homo sapiens_hsa049750.75869501
52Hedgehog signaling pathway_Homo sapiens_hsa043400.73550454
53VEGF signaling pathway_Homo sapiens_hsa043700.72939624
54Arginine biosynthesis_Homo sapiens_hsa002200.72448243
55mRNA surveillance pathway_Homo sapiens_hsa030150.68589705
56ErbB signaling pathway_Homo sapiens_hsa040120.68560506
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.68221796
58Fanconi anemia pathway_Homo sapiens_hsa034600.65374481
59Alcoholism_Homo sapiens_hsa050340.64865396
60Estrogen signaling pathway_Homo sapiens_hsa049150.64854597
61Thyroid hormone synthesis_Homo sapiens_hsa049180.61757007
62p53 signaling pathway_Homo sapiens_hsa041150.60571838
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58273796
64Chronic myeloid leukemia_Homo sapiens_hsa052200.57651394
65Nucleotide excision repair_Homo sapiens_hsa034200.56933095
66Thyroid cancer_Homo sapiens_hsa052160.56342861
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55735223
68Acute myeloid leukemia_Homo sapiens_hsa052210.54696179
69Endocytosis_Homo sapiens_hsa041440.53490991
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53361385
71Prolactin signaling pathway_Homo sapiens_hsa049170.50582187
72Proteoglycans in cancer_Homo sapiens_hsa052050.49492988
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47360235
74Bladder cancer_Homo sapiens_hsa052190.47236541
75Sulfur relay system_Homo sapiens_hsa041220.47170747
76Tight junction_Homo sapiens_hsa045300.46329936
77Choline metabolism in cancer_Homo sapiens_hsa052310.44006637
78Melanoma_Homo sapiens_hsa052180.42595977
79Endometrial cancer_Homo sapiens_hsa052130.41901636
80mTOR signaling pathway_Homo sapiens_hsa041500.41630505
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41180289
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40855575
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39980637
84Systemic lupus erythematosus_Homo sapiens_hsa053220.39328139
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38564107
86Gap junction_Homo sapiens_hsa045400.33348472
87Renin-angiotensin system_Homo sapiens_hsa046140.31432293
88beta-Alanine metabolism_Homo sapiens_hsa004100.31083024
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30164708
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30080145
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.29858312
92Axon guidance_Homo sapiens_hsa043600.29853042
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29334421
94Carbon metabolism_Homo sapiens_hsa012000.28790296
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.28597492
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28445311
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27391005
98Sphingolipid metabolism_Homo sapiens_hsa006000.26214103
99Influenza A_Homo sapiens_hsa051640.26144493
100Insulin signaling pathway_Homo sapiens_hsa049100.25145396

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