ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mitochondrial fission (GO:0090141)	3.83381252
2	cullin deneddylation (GO:0010388)	3.82123808
3	nonmotile primary cilium assembly (GO:0035058)	3.77110769
4	synapsis (GO:0007129)	3.68605302
5	DNA double-strand break processing (GO:0000729)	3.60474216
6	protein deneddylation (GO:0000338)	3.55196942
7	piRNA metabolic process (GO:0034587)	3.54118519
8	response to nitrosative stress (GO:0051409)	3.53413545
9	lipid particle organization (GO:0034389)	3.45720193
10	dermatan sulfate metabolic process (GO:0030205)	3.45619476
11	righting reflex (GO:0060013)	3.44780811
12	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.40748016
13	intraciliary transport (GO:0042073)	3.37609627
14	protein localization to cilium (GO:0061512)	3.37596988
15	platelet dense granule organization (GO:0060155)	3.37185002
16	proteasome assembly (GO:0043248)	3.31278726
17	histone H2A acetylation (GO:0043968)	3.25998508
18	chromosome organization involved in meiosis (GO:0070192)	3.19544675
19	muscle cell cellular homeostasis (GO:0046716)	3.15265467
20	chondroitin sulfate catabolic process (GO:0030207)	3.13813806
21	presynaptic membrane organization (GO:0097090)	3.11886827
22	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.08666184
23	binding of sperm to zona pellucida (GO:0007339)	3.08047243
24	regulation of integrin-mediated signaling pathway (GO:2001044)	3.07408440
25	coenzyme catabolic process (GO:0009109)	3.03601844
26	male meiosis (GO:0007140)	3.02349349
27	peroxisome fission (GO:0016559)	3.00823127
28	presynaptic membrane assembly (GO:0097105)	2.99488739
29	cholesterol biosynthetic process (GO:0006695)	2.99211511
30	peptidyl-histidine modification (GO:0018202)	2.98280900
31	cilium morphogenesis (GO:0060271)	2.96381610
32	cranial nerve morphogenesis (GO:0021602)	2.96089865
33	sterol biosynthetic process (GO:0016126)	2.95812071
34	acrosome assembly (GO:0001675)	2.94794366
35	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.93977120
36	synaptonemal complex assembly (GO:0007130)	2.93171422
37	activation of protein kinase B activity (GO:0032148)	2.92979620
38	synaptonemal complex organization (GO:0070193)	2.92801967
39	isoprenoid biosynthetic process (GO:0008299)	2.91244766
40	response to pheromone (GO:0019236)	2.88833724
41	fibroblast migration (GO:0010761)	2.82930086
42	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.82731812
43	COPII vesicle coating (GO:0048208)	2.81311664
44	negative regulation of axon guidance (GO:1902668)	2.74376836
45	regulation of cilium movement (GO:0003352)	2.68008339
46	ADP metabolic process (GO:0046031)	2.67989876
47	glycosphingolipid biosynthetic process (GO:0006688)	2.66800423
48	cilium assembly (GO:0042384)	2.65476844
49	male meiosis I (GO:0007141)	2.63617910
50	DNA methylation involved in gamete generation (GO:0043046)	2.63370221
51	melanosome localization (GO:0032400)	2.62938995
52	L-methionine biosynthetic process (GO:0071265)	2.62730858
53	amino acid salvage (GO:0043102)	2.62730858
54	L-methionine salvage (GO:0071267)	2.62730858
55	acrosome reaction (GO:0007340)	2.61289369
56	mannosylation (GO:0097502)	2.60923364
57	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.60313123
58	dermatan sulfate biosynthetic process (GO:0030208)	2.60212863
59	cilium organization (GO:0044782)	2.58673486
60	neuron cell-cell adhesion (GO:0007158)	2.57614709
61	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.53750655
62	sperm-egg recognition (GO:0035036)	2.52158579
63	regulation of transmission of nerve impulse (GO:0051969)	2.50463251
64	cellular response to zinc ion (GO:0071294)	2.48380817
65	pigment granule localization (GO:0051875)	2.47071828
66	protein neddylation (GO:0045116)	2.46043758
67	vascular smooth muscle contraction (GO:0014829)	2.40654104
68	epithelial cilium movement (GO:0003351)	2.40357329
69	resolution of meiotic recombination intermediates (GO:0000712)	2.39657971
70	respiratory chain complex IV assembly (GO:0008535)	2.37460839
71	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.35312351
72	regulation of male gonad development (GO:2000018)	2.34243170
73	regulation of mitochondrial fission (GO:0090140)	2.32639384
74	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.32625668
75	protein heterotetramerization (GO:0051290)	2.32317231
76	postsynaptic membrane organization (GO:0001941)	2.31140115
77	ubiquinone metabolic process (GO:0006743)	2.31039808
78	anterograde synaptic vesicle transport (GO:0048490)	2.29405588
79	response to follicle-stimulating hormone (GO:0032354)	2.28418770
80	DNA integration (GO:0015074)	2.27169038
81	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.24362099
82	cellular component assembly involved in morphogenesis (GO:0010927)	2.23450578
83	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.20585987
84	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.20585987
85	tongue development (GO:0043586)	2.19044986
86	glomerular basement membrane development (GO:0032836)	2.18805768
87	pyrimidine nucleobase catabolic process (GO:0006208)	2.18181101
88	reflex (GO:0060004)	2.17757740
89	cellular response to sterol (GO:0036315)	2.17750233
90	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.17590244
91	meiosis I (GO:0007127)	2.16590917
92	mRNA cleavage (GO:0006379)	2.15084083
93	regulation of sarcomere organization (GO:0060297)	2.15072671
94	C-terminal protein amino acid modification (GO:0018410)	2.13371553
95	positive regulation of synapse assembly (GO:0051965)	2.10410264
96	C-terminal protein lipidation (GO:0006501)	2.09159338
97	photoreceptor cell maintenance (GO:0045494)	2.08891877
98	lactate metabolic process (GO:0006089)	2.08877303
99	artery smooth muscle contraction (GO:0014824)	2.08828369
100	positive regulation of protein kinase C signaling (GO:0090037)	2.08642162

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.17090072
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.84790500
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.14984614
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.93569358
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.65318216
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.55576499
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.44765618
8	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.44475370
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.37852789
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27370654
11	FUS_26573619_Chip-Seq_HEK293_Human	2.26841120
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21305263
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14291780
14	VDR_22108803_ChIP-Seq_LS180_Human	2.09306466
15	EWS_26573619_Chip-Seq_HEK293_Human	2.03077725
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.01614386
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95916858
18	P300_19829295_ChIP-Seq_ESCs_Human	1.95181055
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.94694579
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87505492
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85499298
22	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.84002485
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.83646790
24	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83519639
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82418183
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73872426
27	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.68188308
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67324289
29	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.65683717
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64535271
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.56733805
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55919944
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.51594519
34	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.51179888
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.50246000
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48874992
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.48874992
38	BRD4_25478319_ChIP-Seq_HGPS_Human	1.48531207
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47684988
40	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45402661
41	* CJUN_26792858_Chip-Seq_BT549_Human	1.44637047
42	AR_25329375_ChIP-Seq_VCAP_Human	1.43512586
43	TP53_18474530_ChIP-ChIP_U2OS_Human	1.43010162
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42663953
45	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.42121552
46	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.42121552
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42058446
48	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.41890320
49	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.37436035
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36827592
51	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35931138
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.35546242
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35501876
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.35118273
55	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.33853375
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32500757
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.32262676
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31202737
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30737173
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30346340
61	STAT3_23295773_ChIP-Seq_U87_Human	1.29828040
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29569395
63	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.29379644
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.26110764
65	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.24244788
66	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.24003555
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21872751
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18258057
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.17630835
70	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.16886263
71	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16684242
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12869290
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12455641
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12311010
75	DCP1A_22483619_ChIP-Seq_HELA_Human	1.11563183
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10986043
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10687469
78	JUN_21703547_ChIP-Seq_K562_Human	1.10567332
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08780075
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08729303
81	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.08641196
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.07783737
83	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.07693767
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07666659
85	TCF4_23295773_ChIP-Seq_U87_Human	1.07664356
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07152399
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06977753
88	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06190528
89	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06190528
90	VDR_23849224_ChIP-Seq_CD4+_Human	1.04992551
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02120602
92	GABP_19822575_ChIP-Seq_HepG2_Human	1.00437635
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98275037
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97139710
95	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.96700916
96	AHR_22903824_ChIP-Seq_MCF-7_Human	0.96606135
97	SOX9_26525672_Chip-Seq_HEART_Mouse	0.95612927
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95586020
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94810569
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93951065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	3.19336029
2	MP0009780_abnormal_chondrocyte_physiolo	2.77565293
3	MP0006054_spinal_hemorrhage	2.54439733
4	MP0004272_abnormal_basement_membrane	2.50784762
5	MP0004084_abnormal_cardiac_muscle	2.44695866
6	MP0010368_abnormal_lymphatic_system	2.25660044
7	MP0000749_muscle_degeneration	2.04601494
8	MP0000013_abnormal_adipose_tissue	2.04242154
9	MP0009384_cardiac_valve_regurgitation	2.02983827
10	MP0008789_abnormal_olfactory_epithelium	1.96589825
11	MP0002736_abnormal_nociception_after	1.96009093
12	MP0001299_abnormal_eye_distance/	1.91460274
13	MP0002160_abnormal_reproductive_system	1.84822133
14	MP0002102_abnormal_ear_morphology	1.83204608
15	MP0003950_abnormal_plasma_membrane	1.83120415
16	MP0003880_abnormal_central_pattern	1.80521255
17	MP0001984_abnormal_olfaction	1.77767519
18	MP0005394_taste/olfaction_phenotype	1.75438654
19	MP0005499_abnormal_olfactory_system	1.75438654
20	MP0003011_delayed_dark_adaptation	1.65538151
21	MP0005360_urolithiasis	1.58067742
22	MP0008438_abnormal_cutaneous_collagen	1.52949807
23	MP0003279_aneurysm	1.51548286
24	MP0005410_abnormal_fertilization	1.51066709
25	MP0001486_abnormal_startle_reflex	1.48830798
26	MP0005248_abnormal_Harderian_gland	1.47880198
27	MP0001968_abnormal_touch/_nociception	1.47410173
28	MP0001879_abnormal_lymphatic_vessel	1.45381471
29	MP0005253_abnormal_eye_physiology	1.41209080
30	MP0002233_abnormal_nose_morphology	1.40533780
31	MP0005187_abnormal_penis_morphology	1.39583778
32	MP0002234_abnormal_pharynx_morphology	1.39166026
33	MP0001764_abnormal_homeostasis	1.39048394
34	MP0003755_abnormal_palate_morphology	1.36320387
35	MP0009697_abnormal_copulation	1.35614634
36	MP0002837_dystrophic_cardiac_calcinosis	1.30966172
37	MP0009250_abnormal_appendicular_skeleto	1.29793059
38	MP0009046_muscle_twitch	1.28938781
39	MP0002295_abnormal_pulmonary_circulatio	1.28137863
40	MP0001986_abnormal_taste_sensitivity	1.27979694
41	MP0000049_abnormal_middle_ear	1.27926721
42	MP0006072_abnormal_retinal_apoptosis	1.27193901
43	MP0002090_abnormal_vision	1.20023112
44	MP0000538_abnormal_urinary_bladder	1.18700709
45	MP0004484_altered_response_of	1.15653268
46	MP0003186_abnormal_redox_activity	1.15186120
47	MP0008877_abnormal_DNA_methylation	1.13655477
48	MP0000767_abnormal_smooth_muscle	1.12295005
49	MP0000778_abnormal_nervous_system	1.12293701
50	MP0003315_abnormal_perineum_morphology	1.11438968
51	MP0002282_abnormal_trachea_morphology	1.10695778
52	MP0005389_reproductive_system_phenotype	1.10594243
53	MP0003385_abnormal_body_wall	1.09217946
54	MP0005551_abnormal_eye_electrophysiolog	1.09166005
55	MP0001849_ear_inflammation	1.02963682
56	MP0005167_abnormal_blood-brain_barrier	1.02729147
57	MP0002177_abnormal_outer_ear	1.01923047
58	MP0005623_abnormal_meninges_morphology	1.01313424
59	MP0010386_abnormal_urinary_bladder	1.01068295
60	MP0001929_abnormal_gametogenesis	1.00805337
61	MP0004145_abnormal_muscle_electrophysio	1.00440007
62	MP0005084_abnormal_gallbladder_morpholo	0.99994457
63	MP0002210_abnormal_sex_determination	0.99543872
64	MP0005423_abnormal_somatic_nervous	0.98247769
65	MP0004036_abnormal_muscle_relaxation	0.97957344
66	MP0003698_abnormal_male_reproductive	0.97785215
67	MP0005503_abnormal_tendon_morphology	0.97764341
68	MP0002108_abnormal_muscle_morphology	0.95155350
69	MP0004270_analgesia	0.91394655
70	MP0005391_vision/eye_phenotype	0.91260011
71	MP0000427_abnormal_hair_cycle	0.91020868
72	MP0003937_abnormal_limbs/digits/tail_de	0.90533080
73	MP0002127_abnormal_cardiovascular_syste	0.88002048
74	MP0006276_abnormal_autonomic_nervous	0.87889001
75	MP0000762_abnormal_tongue_morphology	0.87762027
76	MP0000516_abnormal_urinary_system	0.86973952
77	MP0005367_renal/urinary_system_phenotyp	0.86973952
78	MP0000653_abnormal_sex_gland	0.86909213
79	MP0005646_abnormal_pituitary_gland	0.86539610
80	MP0002752_abnormal_somatic_nervous	0.83760624
81	MP0008058_abnormal_DNA_repair	0.83627948
82	MP0002184_abnormal_innervation	0.83238628
83	MP0003935_abnormal_craniofacial_develop	0.82317581
84	MP0010030_abnormal_orbit_morphology	0.81794253
85	MP0000647_abnormal_sebaceous_gland	0.80962666
86	MP0002653_abnormal_ependyma_morphology	0.79857054
87	MP0000026_abnormal_inner_ear	0.79802574
88	MP0001145_abnormal_male_reproductive	0.78774753
89	MP0004215_abnormal_myocardial_fiber	0.78460167
90	MP0000751_myopathy	0.77701376
91	MP0002269_muscular_atrophy	0.76968766
92	MP0005620_abnormal_muscle_contractility	0.76346109
93	MP0002116_abnormal_craniofacial_bone	0.75812767
94	MP0003786_premature_aging	0.74622612
95	MP0003221_abnormal_cardiomyocyte_apopto	0.72352886
96	MP0005595_abnormal_vascular_smooth	0.72092652
97	MP0004134_abnormal_chest_morphology	0.71755866
98	MP0001485_abnormal_pinna_reflex	0.70475035
99	MP0002751_abnormal_autonomic_nervous	0.70029544
100	MP0003942_abnormal_urinary_system	0.69358812

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal dysplasia (HP:0007973)	3.93279934
2	Type II lissencephaly (HP:0007260)	3.30588975
3	Medial flaring of the eyebrow (HP:0010747)	3.15166992
4	Congenital primary aphakia (HP:0007707)	3.09799954
5	Nephrogenic diabetes insipidus (HP:0009806)	3.06525813
6	Gait imbalance (HP:0002141)	3.05543046
7	Methylmalonic acidemia (HP:0002912)	2.94676158
8	Tubulointerstitial nephritis (HP:0001970)	2.75533023
9	Cervical subluxation (HP:0003308)	2.52647625
10	True hermaphroditism (HP:0010459)	2.52542807
11	Genital tract atresia (HP:0001827)	2.52202874
12	Vitreoretinal degeneration (HP:0000655)	2.46301748
13	Exercise-induced muscle cramps (HP:0003710)	2.42587212
14	Keratoconus (HP:0000563)	2.42521256
15	Increased corneal curvature (HP:0100692)	2.42521256
16	Bifid tongue (HP:0010297)	2.37587663
17	Vaginal atresia (HP:0000148)	2.36406543
18	Microvesicular hepatic steatosis (HP:0001414)	2.34345909
19	Delayed CNS myelination (HP:0002188)	2.27647525
20	Pancreatic fibrosis (HP:0100732)	2.26468618
21	Molar tooth sign on MRI (HP:0002419)	2.25768540
22	Abnormality of midbrain morphology (HP:0002418)	2.25768540
23	Atonic seizures (HP:0010819)	2.25084243
24	Facial hemangioma (HP:0000329)	2.24126871
25	Nephronophthisis (HP:0000090)	2.22717835
26	Aplasia/Hypoplasia of the lens (HP:0008063)	2.21858848
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20483084
28	Recurrent corneal erosions (HP:0000495)	2.19836108
29	Gonadotropin excess (HP:0000837)	2.18395066
30	Abnormal protein glycosylation (HP:0012346)	2.17832387
31	Abnormal glycosylation (HP:0012345)	2.17832387
32	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.17832387
33	Abnormal protein N-linked glycosylation (HP:0012347)	2.17832387
34	Delayed gross motor development (HP:0002194)	2.16188793
35	Popliteal pterygium (HP:0009756)	2.13425822
36	Aortic regurgitation (HP:0001659)	2.13334292
37	Occipital encephalocele (HP:0002085)	2.09320323
38	Pancreatic cysts (HP:0001737)	2.08304809
39	Reduced antithrombin III activity (HP:0001976)	2.07961815
40	Hypoplasia of the uterus (HP:0000013)	2.07204330
41	Type 2 muscle fiber atrophy (HP:0003554)	2.06993406
42	Type I transferrin isoform profile (HP:0003642)	2.06589430
43	Microglossia (HP:0000171)	2.06360047
44	Postaxial hand polydactyly (HP:0001162)	2.04209945
45	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.03439978
46	Abnormality of lateral ventricle (HP:0030047)	2.02662596
47	Broad foot (HP:0001769)	2.00971345
48	Abnormality of placental membranes (HP:0011409)	2.00561963
49	Amniotic constriction ring (HP:0009775)	2.00561963
50	Methylmalonic aciduria (HP:0012120)	1.99548682
51	Absent speech (HP:0001344)	1.99043256
52	Lissencephaly (HP:0001339)	1.97029815
53	Postnatal microcephaly (HP:0005484)	1.96167170
54	Abnormality of the renal medulla (HP:0100957)	1.94194806
55	Tubulointerstitial abnormality (HP:0001969)	1.92420083
56	Astigmatism (HP:0000483)	1.89734024
57	Poor coordination (HP:0002370)	1.87912704
58	Decreased muscle mass (HP:0003199)	1.86065320
59	J-shaped sella turcica (HP:0002680)	1.82261640
60	Ependymoma (HP:0002888)	1.80704990
61	Cerebellar dysplasia (HP:0007033)	1.80337785
62	Short tibia (HP:0005736)	1.80034626
63	Abnormality of dentin (HP:0010299)	1.79862913
64	Follicular hyperkeratosis (HP:0007502)	1.79588100
65	Hyperglycinemia (HP:0002154)	1.79470639
66	Abnormality of the astrocytes (HP:0100707)	1.76213696
67	Astrocytoma (HP:0009592)	1.76213696
68	Decreased testicular size (HP:0008734)	1.76151143
69	Renal dysplasia (HP:0000110)	1.75958576
70	Disproportionate short-trunk short stature (HP:0003521)	1.75679310
71	Benign neoplasm of the central nervous system (HP:0100835)	1.73061912
72	Adactyly (HP:0009776)	1.72542218
73	Capillary hemangiomas (HP:0005306)	1.72378184
74	Postaxial foot polydactyly (HP:0001830)	1.69935264
75	Metaphyseal dysplasia (HP:0100255)	1.68434827
76	Aplasia/hypoplasia of the uterus (HP:0008684)	1.68110570
77	Fibular aplasia (HP:0002990)	1.66055695
78	Short foot (HP:0001773)	1.65568566
79	Male pseudohermaphroditism (HP:0000037)	1.64642224
80	Median cleft lip (HP:0000161)	1.64406934
81	Hepatocellular necrosis (HP:0001404)	1.62925296
82	Progressive macrocephaly (HP:0004481)	1.61893066
83	Glioma (HP:0009733)	1.61571234
84	Supernumerary spleens (HP:0009799)	1.58126256
85	Abnormality of the intrinsic pathway (HP:0010989)	1.57136829
86	Pterygium (HP:0001059)	1.55604803
87	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.55485345
88	Optic nerve hypoplasia (HP:0000609)	1.54162546
89	Severe Myopia (HP:0011003)	1.53064756
90	Gonadal dysgenesis (HP:0000133)	1.52858068
91	Renal Fanconi syndrome (HP:0001994)	1.52741473
92	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.52217548
93	Bile duct proliferation (HP:0001408)	1.52022513
94	Abnormal biliary tract physiology (HP:0012439)	1.52022513
95	Neoplasm of the oral cavity (HP:0100649)	1.51469216
96	Tubulointerstitial fibrosis (HP:0005576)	1.51227951
97	Hypoplasia of the odontoid process (HP:0003311)	1.50888160
98	Small hand (HP:0200055)	1.50726691
99	Calf muscle hypertrophy (HP:0008981)	1.50570749
100	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.50138588

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.31437736
2	EIF2AK3	3.57796537
3	FRK	3.29011768
4	TRIM28	3.19613420
5	MAP4K2	3.13143368
6	MUSK	2.70939334
7	CASK	2.65303487
8	MAP2K7	2.38821553
9	BMPR1B	2.30985184
10	EIF2AK1	2.24095802
11	MAP3K4	2.17920425
12	BCR	2.15936969
13	MAP3K6	2.05946883
14	STK38L	1.96377642
15	CSNK1G1	1.93704613
16	CSNK1A1L	1.91744075
17	CSNK1G3	1.89912857
18	MYLK	1.83229737
19	WNK3	1.77056913
20	PRKD3	1.74499516
21	ERBB3	1.57663879
22	CSNK1G2	1.56587287
23	NUAK1	1.53887176
24	MAPK13	1.53880369
25	LIMK1	1.53402943
26	PBK	1.33097911
27	PLK2	1.30452084
28	ZAK	1.29302612
29	LATS1	1.24521721
30	PDK2	1.21247148
31	FER	1.21156692
32	PKN2	1.09713746
33	STK39	1.03348805
34	MARK3	1.03289705
35	PTK2B	1.00060640
36	CCNB1	1.00031340
37	EPHB2	0.99200242
38	MAP3K12	0.98922904
39	INSRR	0.98355671
40	BRD4	0.95635333
41	PAK3	0.95165903
42	ADRBK2	0.94890869
43	TIE1	0.93635114
44	SIK3	0.93448040
45	ROCK1	0.92299887
46	MARK1	0.89541947
47	PRKCE	0.88841302
48	TGFBR1	0.87496713
49	GRK1	0.85417389
50	SRPK1	0.83310261
51	ILK	0.81585979
52	OBSCN	0.78265177
53	MET	0.75516498
54	MINK1	0.74191249
55	FLT3	0.73511784
56	PAK4	0.73208754
57	NEK1	0.71564258
58	TESK1	0.69543600
59	KSR1	0.68256810
60	NME1	0.68122020
61	TNK2	0.66880856
62	STK16	0.64507513
63	OXSR1	0.61764215
64	MAP3K5	0.61291375
65	PNCK	0.60151526
66	NEK9	0.59834915
67	MKNK2	0.57951148
68	PLK1	0.55904656
69	DYRK2	0.53229891
70	PHKG1	0.52555306
71	PHKG2	0.52555306
72	PTK2	0.51416916
73	PLK3	0.50893924
74	ROCK2	0.50596772
75	TGFBR2	0.48187689
76	PRKCI	0.47737270
77	NEK2	0.46443643
78	STK38	0.44036105
79	PKN1	0.41846833
80	NTRK2	0.40904847
81	ACVR1B	0.40614185
82	ADRBK1	0.39800670
83	PLK4	0.39719954
84	DDR2	0.38601295
85	CSNK1A1	0.37604106
86	CAMK2A	0.37077645
87	NEK6	0.36522646
88	DYRK3	0.35563827
89	MAP2K4	0.35389797
90	MKNK1	0.34586173
91	AKT2	0.34474455
92	FGFR1	0.34122313
93	MAPK7	0.32355451
94	STK3	0.30854118
95	CAMK2D	0.29727893
96	CDK3	0.29493165
97	CAMK2B	0.29245397
98	EGFR	0.28522618
99	PRKG2	0.28241435
100	SGK223	0.27542868

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.07397242
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.19516579
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.88949590
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.72146286
5	Propanoate metabolism_Homo sapiens_hsa00640	2.13619691
6	Butanoate metabolism_Homo sapiens_hsa00650	2.12128241
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.04472370
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.93512902
9	Fanconi anemia pathway_Homo sapiens_hsa03460	1.93189069
10	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.79262503
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77901655
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74243285
13	Basal transcription factors_Homo sapiens_hsa03022	1.74048986
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.73483194
15	Fatty acid elongation_Homo sapiens_hsa00062	1.72498941
16	Glutathione metabolism_Homo sapiens_hsa00480	1.60200449
17	Regulation of autophagy_Homo sapiens_hsa04140	1.46717984
18	Proteasome_Homo sapiens_hsa03050	1.42765607
19	Circadian rhythm_Homo sapiens_hsa04710	1.42094300
20	Homologous recombination_Homo sapiens_hsa03440	1.37242908
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32740140
22	RNA polymerase_Homo sapiens_hsa03020	1.22033497
23	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.20221290
24	Taste transduction_Homo sapiens_hsa04742	1.18309648
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14720832
26	p53 signaling pathway_Homo sapiens_hsa04115	1.13851491
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.12981144
28	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.11960037
29	Folate biosynthesis_Homo sapiens_hsa00790	1.10813835
30	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.09436212
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.04637609
32	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.04355351
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.03896857
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.02194048
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.00660809
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99602745
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.97942331
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97218039
39	Pyruvate metabolism_Homo sapiens_hsa00620	0.93183551
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.91519911
41	Base excision repair_Homo sapiens_hsa03410	0.90928055
42	Phototransduction_Homo sapiens_hsa04744	0.90423391
43	Oocyte meiosis_Homo sapiens_hsa04114	0.90284490
44	Peroxisome_Homo sapiens_hsa04146	0.89615814
45	Parkinsons disease_Homo sapiens_hsa05012	0.87719893
46	RNA degradation_Homo sapiens_hsa03018	0.86916498
47	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.86670209
48	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.85929401
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82294844
50	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.80442555
51	Sphingolipid metabolism_Homo sapiens_hsa00600	0.79855090
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79354124
53	Purine metabolism_Homo sapiens_hsa00230	0.78581765
54	Vibrio cholerae infection_Homo sapiens_hsa05110	0.78157923
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.77772809
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77264107
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76194184
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74332683
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72984234
60	Olfactory transduction_Homo sapiens_hsa04740	0.70861062
61	Metabolic pathways_Homo sapiens_hsa01100	0.70606983
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70570890
63	GABAergic synapse_Homo sapiens_hsa04727	0.70471653
64	ECM-receptor interaction_Homo sapiens_hsa04512	0.70434447
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.70280890
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70248602
67	Sulfur relay system_Homo sapiens_hsa04122	0.69788598
68	Gap junction_Homo sapiens_hsa04540	0.69645320
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69008322
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68647299
71	Axon guidance_Homo sapiens_hsa04360	0.68497989
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67285974
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65469333
74	Huntingtons disease_Homo sapiens_hsa05016	0.64192207
75	RNA transport_Homo sapiens_hsa03013	0.63696535
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.62715154
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.61754460
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61279343
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60961700
80	Mismatch repair_Homo sapiens_hsa03430	0.58255226
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.57155273
82	Sulfur metabolism_Homo sapiens_hsa00920	0.56405022
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.56170352
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55289341
85	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.54580511
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.54460893
87	Nitrogen metabolism_Homo sapiens_hsa00910	0.54131298
88	Circadian entrainment_Homo sapiens_hsa04713	0.52692357
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51855706
90	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.51735650
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.51725646
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48974153
93	Nicotine addiction_Homo sapiens_hsa05033	0.48675851
94	Salivary secretion_Homo sapiens_hsa04970	0.48100092
95	Linoleic acid metabolism_Homo sapiens_hsa00591	0.47498414
96	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.46043784
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.45709522
98	Alzheimers disease_Homo sapiens_hsa05010	0.44271339
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43955842
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41484971

C2ORF27A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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