ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.68447929
2	DNA synthesis involved in DNA repair (GO:0000731)	9.62138259
3	DNA methylation involved in gamete generation (GO:0043046)	9.60734362
4	meiotic nuclear division (GO:0007126)	8.28538897
5	meiotic cell cycle process (GO:1903046)	6.77211677
6	regulation of meiosis I (GO:0060631)	5.66696944
7	resolution of meiotic recombination intermediates (GO:0000712)	5.59835735
8	reciprocal meiotic recombination (GO:0007131)	5.39684011
9	reciprocal DNA recombination (GO:0035825)	5.39684011
10	sister chromatid cohesion (GO:0007062)	5.10189478
11	histone H3-K9 demethylation (GO:0033169)	4.50950086
12	short-chain fatty acid metabolic process (GO:0046459)	4.40286165
13	female gamete generation (GO:0007292)	4.36514195
14	oogenesis (GO:0048477)	4.29563025
15	meiotic chromosome segregation (GO:0045132)	4.23252946
16	gene silencing by RNA (GO:0031047)	4.05905806
17	positive regulation of meiosis (GO:0045836)	4.01998146
18	DNA alkylation (GO:0006305)	3.97909465
19	DNA methylation (GO:0006306)	3.97909465
20	positive regulation of response to oxidative stress (GO:1902884)	3.91631385
21	positive regulation of cellular response to oxidative stress (GO:1900409)	3.91631385
22	glycerophospholipid catabolic process (GO:0046475)	3.81367502
23	negative regulation of gene silencing (GO:0060969)	3.80633672
24	positive regulation of meiotic cell cycle (GO:0051446)	3.72212781
25	regulation of meiotic cell cycle (GO:0051445)	3.72060810
26	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.45929617
27	cell wall macromolecule catabolic process (GO:0016998)	3.41197986
28	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.40884489
29	histone H4-K12 acetylation (GO:0043983)	3.39337077
30	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.34294718
31	spermatid development (GO:0007286)	3.33024766
32	histone H3-K36 demethylation (GO:0070544)	3.31472401
33	negative regulation of meiosis (GO:0045835)	3.29265722
34	response to pheromone (GO:0019236)	3.26024755
35	proteasome assembly (GO:0043248)	3.23514205
36	peroxisome fission (GO:0016559)	3.17195255
37	DNA methylation or demethylation (GO:0044728)	3.11070690
38	DNA biosynthetic process (GO:0071897)	3.10101702
39	organelle membrane fusion (GO:0090174)	3.05190100
40	fertilization (GO:0009566)	3.00103387
41	regulation of histone H3-K9 methylation (GO:0051570)	2.99763082
42	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.96005071
43	autophagic vacuole fusion (GO:0000046)	2.94291500
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.92101591
45	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	2.91621624
46	germ cell development (GO:0007281)	2.89039599
47	intestinal cholesterol absorption (GO:0030299)	2.82743897
48	myelin maintenance (GO:0043217)	2.77460002
49	cell wall macromolecule metabolic process (GO:0044036)	2.76156620
50	ubiquinone biosynthetic process (GO:0006744)	2.75430612
51	regulation of transcription from RNA polymerase I promoter (GO:0006356)	2.72914650
52	mitochondrial DNA replication (GO:0006264)	2.72294905
53	regulation of meiosis (GO:0040020)	2.70855173
54	negative regulation of meiotic cell cycle (GO:0051447)	2.70161875
55	response to misfolded protein (GO:0051788)	2.69711548
56	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.68583708
57	negative regulation of inclusion body assembly (GO:0090084)	2.67606952
58	regulation of Rac GTPase activity (GO:0032314)	2.67103158
59	DNA modification (GO:0006304)	2.65725862
60	sex differentiation (GO:0007548)	2.65069588
61	histone H2A acetylation (GO:0043968)	2.64534792
62	regulation of microtubule-based movement (GO:0060632)	2.59498763
63	reproductive system development (GO:0061458)	2.54785649
64	regulation of chromatin silencing (GO:0031935)	2.54438686
65	regulation of cilium movement (GO:0003352)	2.51365517
66	protein import into peroxisome matrix (GO:0016558)	2.49506021
67	negative regulation of B cell apoptotic process (GO:0002903)	2.48198271
68	protein complex biogenesis (GO:0070271)	2.47459766
69	mannosylation (GO:0097502)	2.44230461
70	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.43820966
71	intraciliary transport (GO:0042073)	2.40085908
72	binding of sperm to zona pellucida (GO:0007339)	2.39968710
73	gamete generation (GO:0007276)	2.37318653
74	S-adenosylmethionine metabolic process (GO:0046500)	2.36542256
75	spermatogenesis (GO:0007283)	2.36300435
76	male gamete generation (GO:0048232)	2.35946319
77	female mating behavior (GO:0060180)	2.34835172
78	purine deoxyribonucleotide catabolic process (GO:0009155)	2.33909022
79	estrogen biosynthetic process (GO:0006703)	2.32155270
80	seminiferous tubule development (GO:0072520)	2.31783582
81	ovarian follicle development (GO:0001541)	2.30210387
82	regulation of inclusion body assembly (GO:0090083)	2.30203425
83	sperm motility (GO:0030317)	2.29026629
84	regulation of female receptivity (GO:0045924)	2.28163579
85	sperm-egg recognition (GO:0035036)	2.27996978
86	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.26827687
87	long term synaptic depression (GO:0060292)	2.25870777
88	fusion of sperm to egg plasma membrane (GO:0007342)	2.25511574
89	meiotic cell cycle (GO:0051321)	2.25098637
90	regulation of DNA endoreduplication (GO:0032875)	2.25012878
91	retinal cone cell development (GO:0046549)	2.24001986
92	viral protein processing (GO:0019082)	2.22534625
93	coenzyme catabolic process (GO:0009109)	2.22281041
94	synapsis (GO:0007129)	15.9794458
95	male meiosis I (GO:0007141)	12.4271900
96	chromosome organization involved in meiosis (GO:0070192)	12.3593481
97	piRNA metabolic process (GO:0034587)	12.3094387
98	synaptonemal complex assembly (GO:0007130)	11.0566639
99	synaptonemal complex organization (GO:0070193)	10.0830009
100	meiosis I (GO:0007127)	10.0345258

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.95298149
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.55412269
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.20729714
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.82060740
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60384963
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50600886
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.48761984
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.35513974
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.31152303
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.23164248
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21563780
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.06970840
13	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.06596415
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.98347345
15	VDR_22108803_ChIP-Seq_LS180_Human	1.96046175
16	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.93041857
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.81268902
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79972504
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77766083
20	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.76492726
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.76327168
22	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.75313665
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.74521855
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.74208531
25	ERA_21632823_ChIP-Seq_H3396_Human	1.70897787
26	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.70495413
27	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.70495413
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.66458739
29	FUS_26573619_Chip-Seq_HEK293_Human	1.61463399
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.59297757
31	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.57619526
32	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.53857595
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53681672
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.48440958
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47360805
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.47181184
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.46347773
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46107714
39	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.44763308
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.42705951
41	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.40778105
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40267617
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38418299
44	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36373065
45	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.33949430
46	EWS_26573619_Chip-Seq_HEK293_Human	1.30896093
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28728813
48	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.27379249
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26073719
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25160468
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24520757
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24455164
53	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.24231458
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.23749364
55	ERG_20517297_ChIP-Seq_VCAP_Human	1.23715547
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.23692494
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22595517
58	AR_20517297_ChIP-Seq_VCAP_Human	1.19131185
59	GABP_19822575_ChIP-Seq_HepG2_Human	1.17250711
60	KDM5A_27292631_Chip-Seq_BREAST_Human	1.16539355
61	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16368871
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16158618
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15450867
64	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.15299825
65	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.15134626
66	STAT3_23295773_ChIP-Seq_U87_Human	1.14566558
67	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.14341169
68	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.13761340
69	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.13754807
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13257969
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13257969
72	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13133789
73	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11434973
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08995519
75	AR_25329375_ChIP-Seq_VCAP_Human	1.07020253
76	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.06506810
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.05612432
78	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.04302718
79	E2F1_20622854_ChIP-Seq_HELA_Human	1.04154168
80	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.02613294
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99537532
82	CBP_20019798_ChIP-Seq_JUKART_Human	0.99537532
83	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98286829
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98163480
85	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.97943116
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96465001
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95520626
88	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.94943490
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94158743
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92428100
91	NCOR_22424771_ChIP-Seq_293T_Human	0.92386733
92	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92357178
93	SOX2_21211035_ChIP-Seq_LN229_Human	0.90503397
94	TCF4_23295773_ChIP-Seq_U87_Human	0.90221827
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90052733
96	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.89542676
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.89229690
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.88722608
99	PHF8_20622854_ChIP-Seq_HELA_Human	0.88559320
100	P300_19829295_ChIP-Seq_ESCs_Human	0.88284847

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	8.44542591
2	MP0002210_abnormal_sex_determination	3.89026831
3	MP0001929_abnormal_gametogenesis	3.41577605
4	MP0002822_catalepsy	3.15329968
5	MP0001145_abnormal_male_reproductive	2.99695892
6	MP0001661_extended_life_span	2.91133735
7	MP0008058_abnormal_DNA_repair	2.86822680
8	MP0003698_abnormal_male_reproductive	2.85011622
9	MP0000653_abnormal_sex_gland	2.82324166
10	MP0005174_abnormal_tail_pigmentation	2.70079670
11	MP0000569_abnormal_digit_pigmentation	2.54341913
12	MP0002160_abnormal_reproductive_system	2.48893167
13	MP0000015_abnormal_ear_pigmentation	2.36633091
14	MP0002095_abnormal_skin_pigmentation	2.32759302
15	MP0005365_abnormal_bile_salt	2.28608667
16	MP0000013_abnormal_adipose_tissue	2.19538901
17	MP0006036_abnormal_mitochondrial_physio	2.03189541
18	MP0006072_abnormal_retinal_apoptosis	2.03123175
19	MP0005058_abnormal_lysosome_morphology	1.83514280
20	MP0005389_reproductive_system_phenotype	1.81695663
21	MP0005085_abnormal_gallbladder_physiolo	1.79846196
22	MP0008004_abnormal_stomach_pH	1.77816938
23	MP0008995_early_reproductive_senescence	1.70880317
24	MP0005253_abnormal_eye_physiology	1.70531620
25	MP0002638_abnormal_pupillary_reflex	1.66668685
26	MP0001119_abnormal_female_reproductive	1.62013532
27	MP0001984_abnormal_olfaction	1.59367559
28	MP0003136_yellow_coat_color	1.58683216
29	MP0005551_abnormal_eye_electrophysiolog	1.52546610
30	MP0001986_abnormal_taste_sensitivity	1.50697462
31	MP0006035_abnormal_mitochondrial_morpho	1.50613542
32	MP0002161_abnormal_fertility/fecundity	1.49103477
33	MP0005645_abnormal_hypothalamus_physiol	1.47421819
34	MP0003646_muscle_fatigue	1.46066658
35	MP0005410_abnormal_fertilization	1.44852026
36	MP0001666_abnormal_nutrient_absorption	1.41915769
37	MP0002139_abnormal_hepatobiliary_system	1.37485291
38	MP0008789_abnormal_olfactory_epithelium	1.36303689
39	MP0003186_abnormal_redox_activity	1.31153955
40	MP0000427_abnormal_hair_cycle	1.29591633
41	MP0003172_abnormal_lysosome_physiology	1.28477443
42	MP0000383_abnormal_hair_follicle	1.26100340
43	MP0000372_irregular_coat_pigmentation	1.23200096
44	MP0004043_abnormal_pH_regulation	1.21720548
45	MP0002653_abnormal_ependyma_morphology	1.12507906
46	MP0002876_abnormal_thyroid_physiology	1.11177298
47	MP0010678_abnormal_skin_adnexa	1.09984329
48	MP0001529_abnormal_vocalization	1.09805712
49	MP0003011_delayed_dark_adaptation	1.07989677
50	MP0002909_abnormal_adrenal_gland	1.05718943
51	MP0001764_abnormal_homeostasis	1.04899551
52	MP0005646_abnormal_pituitary_gland	1.03228904
53	MP0003806_abnormal_nucleotide_metabolis	1.03087315
54	MP0000678_abnormal_parathyroid_gland	1.03040917
55	MP0003699_abnormal_female_reproductive	1.00446813
56	MP0001664_abnormal_digestion	0.99512233
57	MP0000358_abnormal_cell_content/	0.97841052
58	MP0008007_abnormal_cellular_replicative	0.96755853
59	MP0003786_premature_aging	0.96264585
60	MP0005332_abnormal_amino_acid	0.96159142
61	MP0009745_abnormal_behavioral_response	0.94894494
62	MP0008875_abnormal_xenobiotic_pharmacok	0.93964770
63	MP0003329_amyloid_beta_deposits	0.93599201
64	MP0003195_calcinosis	0.91937927
65	MP0003252_abnormal_bile_duct	0.91075828
66	MP0001944_abnormal_pancreas_morphology	0.86820120
67	MP0005330_cardiomyopathy	0.85186537
68	MP0002693_abnormal_pancreas_physiology	0.83843268
69	MP0001502_abnormal_circadian_rhythm	0.83785884
70	MP0003880_abnormal_central_pattern	0.81788031
71	MP0005499_abnormal_olfactory_system	0.81635693
72	MP0005394_taste/olfaction_phenotype	0.81635693
73	MP0010094_abnormal_chromosome_stability	0.80843932
74	MP0010329_abnormal_lipoprotein_level	0.80492199
75	MP0003718_maternal_effect	0.79987327
76	MP0005636_abnormal_mineral_homeostasis	0.79610750
77	MP0001270_distended_abdomen	0.79096932
78	MP0005647_abnormal_sex_gland	0.77457874
79	MP0005535_abnormal_body_temperature	0.76787030
80	MP0002229_neurodegeneration	0.73087987
81	MP0005391_vision/eye_phenotype	0.72853973
82	MP0001905_abnormal_dopamine_level	0.71568860
83	MP0009697_abnormal_copulation	0.70527394
84	MP0002557_abnormal_social/conspecific_i	0.70333236
85	MP0002938_white_spotting	0.70058897
86	MP0004019_abnormal_vitamin_homeostasis	0.69872327
87	MP0004924_abnormal_behavior	0.69168607
88	MP0005386_behavior/neurological_phenoty	0.69168607
89	MP0001188_hyperpigmentation	0.67668169
90	MP0001765_abnormal_ion_homeostasis	0.66479015
91	MP0003787_abnormal_imprinting	0.66059530
92	MP0002118_abnormal_lipid_homeostasis	0.63265752
93	MP0001919_abnormal_reproductive_system	0.61151230
94	MP0005075_abnormal_melanosome_morpholog	0.61002001
95	MP0000371_diluted_coat_color	0.60003959
96	MP0000003_abnormal_adipose_tissue	0.59467077
97	MP0001970_abnormal_pain_threshold	0.59376280
98	MP0006292_abnormal_olfactory_placode	0.57561872
99	MP0002837_dystrophic_cardiac_calcinosis	0.57388896
100	MP0003693_abnormal_embryo_hatching	0.55802375

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gonadotropin excess (HP:0000837)	4.50914655
2	Proximal tubulopathy (HP:0000114)	4.17439064
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.92020748
4	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.92020748
5	Renal Fanconi syndrome (HP:0001994)	3.68942186
6	Prolonged partial thromboplastin time (HP:0003645)	3.56873115
7	Azoospermia (HP:0000027)	3.51008520
8	3-Methylglutaconic aciduria (HP:0003535)	3.46571775
9	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.37742196
10	Congenital stationary night blindness (HP:0007642)	3.25735315
11	Oligodactyly (hands) (HP:0001180)	3.25717462
12	Osteomalacia (HP:0002749)	3.09523722
13	Abnormality of vitamin metabolism (HP:0100508)	3.00401834
14	Type I transferrin isoform profile (HP:0003642)	2.96664870
15	Methylmalonic acidemia (HP:0002912)	2.94533940
16	Medial flaring of the eyebrow (HP:0010747)	2.93478505
17	Tubulointerstitial nephritis (HP:0001970)	2.92794083
18	Shoulder girdle muscle weakness (HP:0003547)	2.88621984
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.87228541
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.87228541
21	Volvulus (HP:0002580)	2.87181235
22	Spontaneous abortion (HP:0005268)	2.84348175
23	Abnormality of fatty-acid metabolism (HP:0004359)	2.76127432
24	Progressive external ophthalmoplegia (HP:0000590)	2.71607389
25	Type II lissencephaly (HP:0007260)	2.71064593
26	Methylmalonic aciduria (HP:0012120)	2.66313401
27	Hepatocellular necrosis (HP:0001404)	2.65898433
28	Abnormal spermatogenesis (HP:0008669)	2.63545419
29	Abnormality of the corticospinal tract (HP:0002492)	2.63171245
30	Delayed CNS myelination (HP:0002188)	2.63004651
31	Hepatic necrosis (HP:0002605)	2.60144020
32	Abnormality of renal resorption (HP:0011038)	2.58719363
33	Nephronophthisis (HP:0000090)	2.55466526
34	Buphthalmos (HP:0000557)	2.55339809
35	Abnormal protein glycosylation (HP:0012346)	2.54176549
36	Abnormal glycosylation (HP:0012345)	2.54176549
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.54176549
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.54176549
39	Hyperglycinemia (HP:0002154)	2.48873592
40	Abnormality of vitamin B metabolism (HP:0004340)	2.47926279
41	Menstrual irregularities (HP:0000858)	2.42088889
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.40113319
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.39193452
44	Oligodactyly (HP:0012165)	2.37483502
45	Bundle branch block (HP:0011710)	2.36034391
46	Horizontal nystagmus (HP:0000666)	2.35343535
47	Increased intramyocellular lipid droplets (HP:0012240)	2.30505492
48	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.30248023
49	Urethral obstruction (HP:0000796)	2.30011091
50	Congenital primary aphakia (HP:0007707)	2.28298624
51	Hyperpituitarism (HP:0010514)	2.27931905
52	Hypercholesterolemia (HP:0003124)	2.27643376
53	Increased CSF lactate (HP:0002490)	2.26493074
54	Cutaneous melanoma (HP:0012056)	2.24889620
55	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.21988845
56	Dicarboxylic aciduria (HP:0003215)	2.21988845
57	Gait imbalance (HP:0002141)	2.21842566
58	Fatigue (HP:0012378)	2.17864341
59	Hypothermia (HP:0002045)	2.17349923
60	Atelectasis (HP:0100750)	2.17163896
61	Hypokinesia (HP:0002375)	2.14373642
62	Mitochondrial inheritance (HP:0001427)	2.12605027
63	Brushfield spots (HP:0001088)	2.10750201
64	Brittle hair (HP:0002299)	2.09795514
65	Hyperthyroidism (HP:0000836)	2.08778441
66	Growth hormone excess (HP:0000845)	2.06999347
67	Abnormality of the renal medulla (HP:0100957)	2.05439725
68	Hyperphosphaturia (HP:0003109)	2.05088099
69	Progressive macrocephaly (HP:0004481)	2.03296300
70	Acute necrotizing encephalopathy (HP:0006965)	2.00800056
71	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.00688929
72	Ketoacidosis (HP:0001993)	2.00679960
73	Nephrogenic diabetes insipidus (HP:0009806)	2.00038345
74	Neoplasm of the adrenal gland (HP:0100631)	1.99539794
75	Increased muscle lipid content (HP:0009058)	1.96942731
76	Large hands (HP:0001176)	1.96252081
77	Rimmed vacuoles (HP:0003805)	1.95401103
78	Neoplasm of the adrenal cortex (HP:0100641)	1.94184832
79	Ketosis (HP:0001946)	1.92217023
80	Abnormality of subcutaneous fat tissue (HP:0001001)	1.91465726
81	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.90722825
82	Abnormality of the anterior horn cell (HP:0006802)	1.88017487
83	Degeneration of anterior horn cells (HP:0002398)	1.88017487
84	Increased serum lactate (HP:0002151)	1.87079679
85	Tongue fasciculations (HP:0001308)	1.86744184
86	Abnormality of the dental root (HP:0006486)	1.86438386
87	Taurodontia (HP:0000679)	1.86438386
88	Abnormality of permanent molar morphology (HP:0011071)	1.86438386
89	Agammaglobulinemia (HP:0004432)	1.85786285
90	Abnormality of the pupil (HP:0000615)	1.85758022
91	Chronic sinusitis (HP:0011109)	1.82781953
92	Abnormality of dentin (HP:0010299)	1.81270544
93	Epiphyseal stippling (HP:0010655)	1.80282906
94	Abnormality of the renal cortex (HP:0011035)	1.80151372
95	Abnormal pupillary function (HP:0007686)	1.80112762
96	Dysphonia (HP:0001618)	1.79374463
97	Congenital glaucoma (HP:0001087)	1.78742500
98	Hypoplasia of the fovea (HP:0007750)	1.78679477
99	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.78679477
100	Status epilepticus (HP:0002133)	1.78513773

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	7.80720045
2	GRK1	4.21805771
3	TRIM28	3.95505188
4	FRK	3.88021515
5	PNCK	3.70690316
6	CDK19	3.61115402
7	PINK1	2.77117571
8	MET	2.67532571
9	PRKD3	2.61586748
10	PDK2	2.59595248
11	STK24	2.43242192
12	STK38L	2.37170122
13	BCKDK	2.11916566
14	OXSR1	1.98436778
15	MST1R	1.79124714
16	BMX	1.64004291
17	CCNB1	1.63980182
18	STK38	1.54618284
19	MAP3K12	1.52895016
20	PTK2B	1.52202924
21	CAMK1G	1.50339188
22	FGFR2	1.35229836
23	EIF2AK1	1.29142587
24	ZAK	1.27146062
25	MARK3	1.13680525
26	CSNK1G2	1.13651168
27	WNK4	1.05878180
28	PRKCI	1.05713064
29	MAP3K13	1.04386369
30	MAPK13	1.02302901
31	CSF1R	0.99624486
32	SCYL2	0.97239661
33	MAP2K2	0.95980447
34	CSNK1G3	0.91520468
35	CSNK1G1	0.89573113
36	STK16	0.88078887
37	PHKG1	0.84600477
38	PHKG2	0.84600477
39	MST4	0.82830216
40	PBK	0.74331631
41	STK39	0.73322669
42	FGFR3	0.70880589
43	EIF2AK3	0.69293209
44	CASK	0.68572852
45	MAPKAPK3	0.68551285
46	PLK2	0.68200874
47	FLT3	0.66267057
48	MKNK2	0.64708872
49	BRAF	0.62192044
50	MAP3K11	0.62055177
51	FGR	0.55761177
52	ATR	0.55361544
53	ARAF	0.54146505
54	STK11	0.48246789
55	PRKCZ	0.47080338
56	TNK2	0.44508034
57	CAMK2D	0.44171431
58	NUAK1	0.41836370
59	PLK1	0.41675175
60	TBK1	0.41310773
61	MAP3K9	0.41134693
62	KSR1	0.40543266
63	NTRK3	0.38354831
64	DAPK1	0.37068259
65	TTK	0.36959835
66	CSNK1A1L	0.35846811
67	IGF1R	0.35344479
68	EGFR	0.35024467
69	TYK2	0.34274153
70	ATM	0.34225585
71	STK3	0.33120912
72	INSRR	0.31577193
73	CAMK2G	0.31110632
74	PRKCE	0.30705233
75	TAF1	0.28893454
76	MAP2K6	0.28045661
77	VRK1	0.27950193
78	CAMK1	0.27801351
79	CSNK1E	0.26623666
80	PRKD2	0.26097152
81	PRKACB	0.23382158
82	VRK2	0.21584097
83	TAOK3	0.20187048
84	FER	0.19429045
85	UHMK1	0.19356752
86	KIT	0.18730541
87	CSNK2A2	0.18377212
88	PRKAA1	0.17870816
89	PRKCQ	0.17611924
90	CHEK1	0.17067226
91	CAMK2B	0.17037351
92	RPS6KA5	0.15422300
93	AURKA	0.12976367
94	PTK2	0.12783835
95	ADRBK2	0.12379719
96	CSNK2A1	0.12294198
97	CSNK1A1	0.12238375
98	CAMK2A	0.12215832
99	PAK3	0.11167406
100	NEK9	0.11046301

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.98646512
2	Homologous recombination_Homo sapiens_hsa03440	2.79704316
3	Propanoate metabolism_Homo sapiens_hsa00640	2.71334689
4	Phototransduction_Homo sapiens_hsa04744	2.53616280
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.53175406
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.41148669
7	Peroxisome_Homo sapiens_hsa04146	2.32592596
8	Parkinsons disease_Homo sapiens_hsa05012	2.15535622
9	Proteasome_Homo sapiens_hsa03050	2.08391327
10	beta-Alanine metabolism_Homo sapiens_hsa00410	2.07415000
11	Protein export_Homo sapiens_hsa03060	1.95588056
12	One carbon pool by folate_Homo sapiens_hsa00670	1.95519627
13	Glutathione metabolism_Homo sapiens_hsa00480	1.90288601
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.88277132
15	Fatty acid elongation_Homo sapiens_hsa00062	1.78176665
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.75071002
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.72686725
18	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.69611083
19	Butanoate metabolism_Homo sapiens_hsa00650	1.67640200
20	Pyruvate metabolism_Homo sapiens_hsa00620	1.65186316
21	Regulation of autophagy_Homo sapiens_hsa04140	1.54778394
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.53309854
23	Mismatch repair_Homo sapiens_hsa03430	1.48825750
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.48816576
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.47903639
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.44176521
27	Huntingtons disease_Homo sapiens_hsa05016	1.42699810
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.42060283
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.40804949
30	ABC transporters_Homo sapiens_hsa02010	1.40475547
31	Base excision repair_Homo sapiens_hsa03410	1.38830266
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.37711257
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.35094644
34	Sulfur metabolism_Homo sapiens_hsa00920	1.35047328
35	Folate biosynthesis_Homo sapiens_hsa00790	1.34901108
36	Circadian rhythm_Homo sapiens_hsa04710	1.32574477
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.31615166
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28039741
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20457233
40	Retinol metabolism_Homo sapiens_hsa00830	1.19916199
41	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.19648592
42	Fatty acid degradation_Homo sapiens_hsa00071	1.19485900
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18663133
44	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.17846546
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.15018943
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.14810133
47	Other glycan degradation_Homo sapiens_hsa00511	1.10399877
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08382281
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08021169
50	DNA replication_Homo sapiens_hsa03030	1.04994750
51	Metabolic pathways_Homo sapiens_hsa01100	1.03713898
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99349536
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99343509
54	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.97563008
55	Lysine degradation_Homo sapiens_hsa00310	0.97268329
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96302417
57	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.88757169
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86545564
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.83011964
60	Insulin secretion_Homo sapiens_hsa04911	0.79543950
61	Oocyte meiosis_Homo sapiens_hsa04114	0.79147703
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78131027
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76939919
64	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.75963090
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75560765
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.73309265
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.73021224
68	Histidine metabolism_Homo sapiens_hsa00340	0.72762436
69	RNA degradation_Homo sapiens_hsa03018	0.72512843
70	Lysosome_Homo sapiens_hsa04142	0.71936274
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.69177656
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69036341
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68779262
74	Olfactory transduction_Homo sapiens_hsa04740	0.66549562
75	RNA transport_Homo sapiens_hsa03013	0.64910693
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.63827101
77	Alzheimers disease_Homo sapiens_hsa05010	0.58555223
78	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58456708
79	Taste transduction_Homo sapiens_hsa04742	0.58006404
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56031696
81	Sulfur relay system_Homo sapiens_hsa04122	0.55940944
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.55890524
83	p53 signaling pathway_Homo sapiens_hsa04115	0.54990475
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54941649
85	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54909533
86	Carbon metabolism_Homo sapiens_hsa01200	0.53383586
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.53149699
88	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52405509
89	Antigen processing and presentation_Homo sapiens_hsa04612	0.51278608
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49587352
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.49311577
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47443108
93	Purine metabolism_Homo sapiens_hsa00230	0.46717515
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46255157
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.44234155
96	Complement and coagulation cascades_Homo sapiens_hsa04610	0.40417811
97	Asthma_Homo sapiens_hsa05310	0.39381973
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36586740
99	Basal transcription factors_Homo sapiens_hsa03022	0.35645243
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.35390605

C2ORF27AP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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