C2ORF42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1organic cation transport (GO:0015695)4.07973714
2L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77693391
3negative regulation of cell killing (GO:0031342)3.68830780
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.68830780
5response to interleukin-15 (GO:0070672)3.65188744
6positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.62462750
7microtubule nucleation (GO:0007020)3.54594542
8negative regulation of cAMP-mediated signaling (GO:0043951)3.54338233
9regulation of B cell receptor signaling pathway (GO:0050855)3.38667304
10cellular response to interleukin-15 (GO:0071350)3.30439511
11germinal center formation (GO:0002467)3.27353924
12T cell migration (GO:0072678)3.11564254
13histone H3-K9 modification (GO:0061647)3.09615667
14negative regulation of NF-kappaB import into nucleus (GO:0042347)3.09152921
15amino acid salvage (GO:0043102)3.06295473
16L-methionine salvage (GO:0071267)3.06295473
17L-methionine biosynthetic process (GO:0071265)3.06295473
18cilium or flagellum-dependent cell motility (GO:0001539)3.03360163
19male meiosis I (GO:0007141)3.00317039
20mannosylation (GO:0097502)2.99173143
21piRNA metabolic process (GO:0034587)2.99030049
22positive regulation of gamma-delta T cell activation (GO:0046645)2.98233370
23histone H3-K9 methylation (GO:0051567)2.97143085
24positive regulation of interleukin-2 production (GO:0032743)2.95787176
25tolerance induction (GO:0002507)2.94401623
26positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.94347107
27regulation of defense response to virus by host (GO:0050691)2.92925017
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92190232
29toxin transport (GO:1901998)2.85899066
30negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.84955220
31positive regulation of defense response to virus by host (GO:0002230)2.84140856
32positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.83527022
33rRNA catabolic process (GO:0016075)2.83012055
34membrane protein intracellular domain proteolysis (GO:0031293)2.76669000
35regulation of alpha-beta T cell proliferation (GO:0046640)2.74847180
36response to lipoprotein particle (GO:0055094)2.73291613
37amyloid precursor protein catabolic process (GO:0042987)2.72720444
38negative regulation of lymphocyte mediated immunity (GO:0002707)2.72416498
39response to muramyl dipeptide (GO:0032495)2.71480691
40regulation of T cell tolerance induction (GO:0002664)2.65973261
41regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.65049497
42positive regulation of alpha-beta T cell proliferation (GO:0046641)2.64988173
43synaptonemal complex assembly (GO:0007130)2.64435197
44positive regulation of protein homooligomerization (GO:0032464)2.64102557
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63699980
46positive regulation of DNA recombination (GO:0045911)2.61880948
47snRNA processing (GO:0016180)2.60935498
48response to type I interferon (GO:0034340)2.60039930
49meiosis I (GO:0007127)2.59452046
50histone H3-K4 trimethylation (GO:0080182)2.59430083
51regulation of gamma-delta T cell differentiation (GO:0045586)2.58966670
52pyrimidine dimer repair (GO:0006290)2.58434186
53positive regulation of isotype switching (GO:0045830)2.57021455
54antigen processing and presentation via MHC class Ib (GO:0002475)2.56568609
55RNA destabilization (GO:0050779)2.55555972
56type I interferon signaling pathway (GO:0060337)2.55468931
57cellular response to type I interferon (GO:0071357)2.55468931
58DNA methylation involved in gamete generation (GO:0043046)2.54731534
59regulation of gamma-delta T cell activation (GO:0046643)2.50870636
60cellular response to exogenous dsRNA (GO:0071360)2.48679457
61positive regulation of mitochondrial fission (GO:0090141)2.48453508
62labyrinthine layer development (GO:0060711)2.47818038
63regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.47729195
64regulation of germinal center formation (GO:0002634)2.47152418
65N-acetylneuraminate metabolic process (GO:0006054)2.46987809
66negative regulation of T cell mediated immunity (GO:0002710)2.46064253
67protein K11-linked deubiquitination (GO:0035871)2.44759598
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44381326
69snRNA metabolic process (GO:0016073)2.43404599
70positive regulation of interleukin-4 production (GO:0032753)2.42555816
71regulation of interleukin-2 biosynthetic process (GO:0045076)2.41816583
72negative regulation of T cell apoptotic process (GO:0070233)2.41726311
73peptidyl-threonine dephosphorylation (GO:0035970)2.41426204
74positive regulation of T-helper cell differentiation (GO:0045624)2.40189721
75erythrocyte development (GO:0048821)2.39228466
76synaptonemal complex organization (GO:0070193)2.37883770
77meiotic chromosome segregation (GO:0045132)2.37285737
78positive regulation of T cell mediated cytotoxicity (GO:0001916)2.36948125
79positive regulation of digestive system process (GO:0060456)2.36661721
80defense response to protozoan (GO:0042832)2.36411898
81negative regulation of interleukin-8 production (GO:0032717)2.36284307
82positive regulation of interferon-beta production (GO:0032728)2.35946091
83negative regulation of interleukin-6 production (GO:0032715)2.35596827
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33637579
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.33461695
86lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33365487
87organelle membrane fusion (GO:0090174)2.32962133
88regulation of hypersensitivity (GO:0002883)2.32627000
89regulation of cilium movement (GO:0003352)2.32599330
90regulation of T-helper cell differentiation (GO:0045622)2.32434692
91protein targeting to Golgi (GO:0000042)2.31484063
92regulation of interferon-beta biosynthetic process (GO:0045357)2.31250988
93interferon-gamma production (GO:0032609)2.30750079
94negative regulation of myeloid cell apoptotic process (GO:0033033)2.29417881
95regulation of T cell mediated cytotoxicity (GO:0001914)2.28487658
96regulation of interferon-beta production (GO:0032648)2.27536896
97base-excision repair, AP site formation (GO:0006285)2.26608572
98negative regulation of leukocyte mediated immunity (GO:0002704)2.26460938
99positive regulation of humoral immune response (GO:0002922)2.26182995
100macroautophagy (GO:0016236)2.26145371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.90686494
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.55864251
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.48025526
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09532506
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08185773
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07211596
7* NOTCH1_21737748_ChIP-Seq_TLL_Human2.98948350
8EZH2_22144423_ChIP-Seq_EOC_Human2.97481364
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88097885
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68799024
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68737952
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57974295
13VDR_23849224_ChIP-Seq_CD4+_Human2.41124078
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41010618
15MYB_26560356_Chip-Seq_TH2_Human2.38470346
16FOXP3_21729870_ChIP-Seq_TREG_Human2.17174014
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.06630555
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.06359220
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03095836
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01059362
21SPI1_23547873_ChIP-Seq_NB4_Human1.99319987
22GATA1_22025678_ChIP-Seq_K562_Human1.97471405
23IRF1_19129219_ChIP-ChIP_H3396_Human1.96911635
24MYB_26560356_Chip-Seq_TH1_Human1.93551952
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91170275
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90218685
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85335921
28MAF_26560356_Chip-Seq_TH1_Human1.84768966
29TFEB_21752829_ChIP-Seq_HELA_Human1.80068812
30GATA3_27048872_Chip-Seq_THYMUS_Human1.78386020
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76469404
32RUNX_20019798_ChIP-Seq_JUKART_Human1.76171146
33ZNF274_21170338_ChIP-Seq_K562_Hela1.74090634
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72918155
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70307395
36CIITA_25753668_ChIP-Seq_RAJI_Human1.69309092
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65801531
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64473577
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64094689
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63221481
41IGF1R_20145208_ChIP-Seq_DFB_Human1.61518993
42* GABP_19822575_ChIP-Seq_HepG2_Human1.61012051
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60638059
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.60638027
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54740745
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50362457
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47665113
48MAF_26560356_Chip-Seq_TH2_Human1.47015557
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46937139
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46334844
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43050273
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40973047
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40683552
54* UTX_26944678_Chip-Seq_JUKART_Human1.39086678
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38434285
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38375923
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.37938596
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33309379
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.33090299
60GATA3_26560356_Chip-Seq_TH2_Human1.30291146
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29437602
62* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29098904
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24259103
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22196063
65BCL6_27268052_Chip-Seq_Bcells_Human1.22167500
66VDR_21846776_ChIP-Seq_THP-1_Human1.21862143
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21258680
68MYC_18940864_ChIP-ChIP_HL60_Human1.18985298
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16853774
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16032356
71DCP1A_22483619_ChIP-Seq_HELA_Human1.14906813
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14832474
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.13496067
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09875591
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09480059
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08023176
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06549778
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06549453
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06135527
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04638583
81VDR_24763502_ChIP-Seq_THP-1_Human0.98591642
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98549960
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98241486
84RUNX1_22412390_ChIP-Seq_EML_Mouse0.97838349
85* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97315655
86ERG_20517297_ChIP-Seq_VCAP_Human0.93862295
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93834746
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93635773
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92062114
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.91835697
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90958121
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89952457
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.89232420
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89211408
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89160574
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89127108
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89047268
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89040196
99NANOG_20526341_ChIP-Seq_ESCs_Human0.87974339
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87091125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract3.21798797
2MP0001835_abnormal_antigen_presentation3.01697055
3MP0003436_decreased_susceptibility_to3.01340122
4MP0005671_abnormal_response_to2.92771792
5MP0003787_abnormal_imprinting2.77860004
6MP0009785_altered_susceptibility_to2.38387399
7MP0003303_peritoneal_inflammation2.33658990
8MP0003763_abnormal_thymus_physiology2.33566734
9MP0009764_decreased_sensitivity_to2.31795906
10MP0005000_abnormal_immune_tolerance2.28551931
11MP0001764_abnormal_homeostasis2.24564471
12MP0003724_increased_susceptibility_to2.23153054
13MP0006082_CNS_inflammation2.19117518
14MP0001800_abnormal_humoral_immune2.18010700
15MP0002723_abnormal_immune_serum2.16371501
16MP0002102_abnormal_ear_morphology2.04999711
17MP0005025_abnormal_response_to1.95028331
18MP0009333_abnormal_splenocyte_physiolog1.88765952
19MP0002420_abnormal_adaptive_immunity1.87648500
20MP0002452_abnormal_antigen_presenting1.87135058
21MP0005310_abnormal_salivary_gland1.86660878
22MP0001819_abnormal_immune_cell1.86440053
23MP0008058_abnormal_DNA_repair1.85364010
24MP0002419_abnormal_innate_immunity1.84736264
25MP0009840_abnormal_foam_cell1.82796236
26MP0002132_abnormal_respiratory_system1.81591515
27MP0003656_abnormal_erythrocyte_physiolo1.77581114
28MP0002148_abnormal_hypersensitivity_rea1.76188271
29MP0003718_maternal_effect1.75410321
30MP0003646_muscle_fatigue1.74099035
31MP0009278_abnormal_bone_marrow1.72402891
32MP0000685_abnormal_immune_system1.70690558
33MP0005410_abnormal_fertilization1.69052719
34MP0002398_abnormal_bone_marrow1.65710381
35MP0002332_abnormal_exercise_endurance1.65630940
36MP0003011_delayed_dark_adaptation1.63261291
37MP0000716_abnormal_immune_system1.62023069
38MP0000689_abnormal_spleen_morphology1.59386289
39MP0005499_abnormal_olfactory_system1.55446077
40MP0005394_taste/olfaction_phenotype1.55446077
41MP0002405_respiratory_system_inflammati1.54008410
42MP0003880_abnormal_central_pattern1.52749667
43MP0005387_immune_system_phenotype1.51956892
44MP0001790_abnormal_immune_system1.51956892
45MP0005084_abnormal_gallbladder_morpholo1.51447282
46MP0004484_altered_response_of1.51243603
47MP0002722_abnormal_immune_system1.50006100
48MP0000015_abnormal_ear_pigmentation1.49178597
49MP0000465_gastrointestinal_hemorrhage1.47459986
50MP0008789_abnormal_olfactory_epithelium1.47012327
51MP0000703_abnormal_thymus_morphology1.41935840
52MP0006276_abnormal_autonomic_nervous1.33948607
53MP0005464_abnormal_platelet_physiology1.33675164
54MP0008877_abnormal_DNA_methylation1.31217477
55MP0001845_abnormal_inflammatory_respons1.29073485
56MP0002429_abnormal_blood_cell1.26284402
57MP0002653_abnormal_ependyma_morphology1.24778392
58MP0003191_abnormal_cellular_cholesterol1.20250037
59MP0005647_abnormal_sex_gland1.19247623
60MP0003806_abnormal_nucleotide_metabolis1.18757878
61MP0010155_abnormal_intestine_physiology1.18552426
62MP0004233_abnormal_muscle_weight1.18372470
63MP0005365_abnormal_bile_salt1.12973364
64MP0005376_homeostasis/metabolism_phenot1.12042451
65MP0005085_abnormal_gallbladder_physiolo1.11136520
66MP0008469_abnormal_protein_level1.09823448
67MP0001533_abnormal_skeleton_physiology1.08214519
68MP0004947_skin_inflammation1.05715617
69MP0000569_abnormal_digit_pigmentation1.04449424
70MP0003959_abnormal_lean_body0.99803554
71MP0009765_abnormal_xenobiotic_induced0.99138413
72MP0005058_abnormal_lysosome_morphology0.95543476
73MP0005266_abnormal_metabolism0.94639451
74MP0005075_abnormal_melanosome_morpholog0.93774577
75MP0005645_abnormal_hypothalamus_physiol0.92321446
76MP0004142_abnormal_muscle_tone0.92285101
77MP0003698_abnormal_male_reproductive0.92253729
78MP0001929_abnormal_gametogenesis0.92021379
79MP0002928_abnormal_bile_duct0.91938609
80MP0003252_abnormal_bile_duct0.91725308
81MP0004883_abnormal_blood_vessel0.90738998
82MP0005253_abnormal_eye_physiology0.90490875
83MP0005423_abnormal_somatic_nervous0.86798170
84MP0003221_abnormal_cardiomyocyte_apopto0.85966478
85MP0005395_other_phenotype0.84386342
86MP0001545_abnormal_hematopoietic_system0.81703537
87MP0005397_hematopoietic_system_phenotyp0.81703537
88MP0003172_abnormal_lysosome_physiology0.80903911
89MP0000343_altered_response_to0.80734850
90MP0003121_genomic_imprinting0.78138045
91MP0009697_abnormal_copulation0.75320619
92MP0002138_abnormal_hepatobiliary_system0.75296111
93MP0002139_abnormal_hepatobiliary_system0.73459060
94MP0002210_abnormal_sex_determination0.69110111
95MP0005319_abnormal_enzyme/_coenzyme0.67650761
96MP0000609_abnormal_liver_physiology0.67189901
97MP0005166_decreased_susceptibility_to0.66423861
98MP0001873_stomach_inflammation0.65403562
99MP0000249_abnormal_blood_vessel0.64802982
100MP0009763_increased_sensitivity_to0.64597640

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.20683209
2Severe visual impairment (HP:0001141)4.11910691
3Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.10615446
4Stomatitis (HP:0010280)4.00036518
5Hypoplasia of the thymus (HP:0000778)3.93602051
6Elevated erythrocyte sedimentation rate (HP:0003565)3.47977230
7Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94155233
8Myositis (HP:0100614)2.93150917
9Abnormality of glycolipid metabolism (HP:0010969)2.87889300
10Abnormality of liposaccharide metabolism (HP:0010968)2.87889300
11Abnormality of glycosphingolipid metabolism (HP:0004343)2.87889300
12Recurrent bacterial skin infections (HP:0005406)2.83515571
13Abnormality of the prostate (HP:0008775)2.75220324
14Supranuclear gaze palsy (HP:0000605)2.71481622
15Loss of speech (HP:0002371)2.71361690
16Abnormality of macular pigmentation (HP:0008002)2.67428422
17Stomach cancer (HP:0012126)2.64939723
18Increased neuronal autofluorescent lipopigment (HP:0002074)2.62097449
19Hypochromic anemia (HP:0001931)2.59314975
20T lymphocytopenia (HP:0005403)2.54464074
21Abnormal protein glycosylation (HP:0012346)2.53396123
22Abnormal glycosylation (HP:0012345)2.53396123
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.53396123
24Abnormal protein N-linked glycosylation (HP:0012347)2.53396123
25Increased cerebral lipofuscin (HP:0011813)2.52207037
26Bony spicule pigmentary retinopathy (HP:0007737)2.50448440
27Orchitis (HP:0100796)2.50100421
28Abnormality of eosinophils (HP:0001879)2.48900107
29Retrobulbar optic neuritis (HP:0100654)2.48546541
30Optic neuritis (HP:0100653)2.48546541
31Spontaneous hematomas (HP:0007420)2.47447354
32Aplasia/Hypoplasia of the thymus (HP:0010515)2.46061724
33Abnormality of fatty-acid metabolism (HP:0004359)2.44826068
34Recurrent abscess formation (HP:0002722)2.40096177
35Abnormality of T cell number (HP:0011839)2.39602586
36Polycythemia (HP:0001901)2.38655467
37Gastrointestinal infarctions (HP:0005244)2.33034546
38Eosinophilia (HP:0001880)2.30064597
39Granulocytopenia (HP:0001913)2.27686884
40Severe combined immunodeficiency (HP:0004430)2.25591520
41Panhypogammaglobulinemia (HP:0003139)2.23616985
42Hematochezia (HP:0002573)2.23201684
43Chronic obstructive pulmonary disease (HP:0006510)2.20382191
44Obstructive lung disease (HP:0006536)2.20382191
45Amyotrophic lateral sclerosis (HP:0007354)2.17842721
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17261550
47Hypergonadotropic hypogonadism (HP:0000815)2.16784335
48Autoimmune hemolytic anemia (HP:0001890)2.16057780
49Chest pain (HP:0100749)2.15382265
50Abnormality of T cells (HP:0002843)2.15342155
51Prolonged neonatal jaundice (HP:0006579)2.14991152
52Vasculitis (HP:0002633)2.14932708
53Nephroblastoma (Wilms tumor) (HP:0002667)2.12641436
54Thyroiditis (HP:0100646)2.12356199
55Abnormal biliary tract physiology (HP:0012439)2.11692594
56Bile duct proliferation (HP:0001408)2.11692594
57Albinism (HP:0001022)2.10996322
58Encephalitis (HP:0002383)2.09549302
59Cerebellar dysplasia (HP:0007033)2.08198450
60Leukocytosis (HP:0001974)2.06950227
61Thoracolumbar scoliosis (HP:0002944)2.05422952
62Episodic fever (HP:0001954)2.05182641
63Eczematoid dermatitis (HP:0000976)2.04202668
64Abnormal rod and cone electroretinograms (HP:0008323)2.03248920
65Recurrent viral infections (HP:0004429)2.02916592
66Hip dysplasia (HP:0001385)2.02246659
67Alveolar cell carcinoma (HP:0006519)2.01275142
68Recurrent fungal infections (HP:0002841)1.99962069
69Microretrognathia (HP:0000308)1.97813050
70Acute lymphatic leukemia (HP:0006721)1.97547480
71Shoulder girdle muscle weakness (HP:0003547)1.97506731
72Chronic hepatic failure (HP:0100626)1.97417427
73Hypoplastic left heart (HP:0004383)1.96869944
74Recurrent gram-negative bacterial infections (HP:0005420)1.96329146
75Rimmed vacuoles (HP:0003805)1.92957857
76Progressive inability to walk (HP:0002505)1.91098383
77Embryonal renal neoplasm (HP:0011794)1.90958462
78Abnormal delayed hypersensitivity skin test (HP:0002963)1.89315494
79Glomerulopathy (HP:0100820)1.88625849
80Attenuation of retinal blood vessels (HP:0007843)1.88010381
81Lymphopenia (HP:0001888)1.86523009
82Opisthotonus (HP:0002179)1.86319618
83Pulmonary fibrosis (HP:0002206)1.85486714
84Brushfield spots (HP:0001088)1.84106490
85Abnormality of B cell number (HP:0010975)1.83748794
86Inflammation of the large intestine (HP:0002037)1.83596385
87Reduced antithrombin III activity (HP:0001976)1.81329942
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81246525
89Meningitis (HP:0001287)1.80695101
90Abnormality of macrophages (HP:0004311)1.80411688
91Recurrent sinusitis (HP:0011108)1.79578578
92Abnormal pupillary function (HP:0007686)1.78751244
93Delusions (HP:0000746)1.77909047
94Pelvic girdle muscle weakness (HP:0003749)1.76198008
95Tubulointerstitial nephritis (HP:0001970)1.75875286
96Recurrent skin infections (HP:0001581)1.74229826
97Abnormal gallbladder physiology (HP:0012438)1.73828487
98Cholecystitis (HP:0001082)1.73828487
99Combined immunodeficiency (HP:0005387)1.73420146
100Subaortic stenosis (HP:0001682)1.69940842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.12353842
2MAP4K13.28758994
3CAMKK23.07196196
4TESK22.83637571
5BLK2.79985399
6TYK22.47888020
7ZAK2.36679015
8TXK2.31792905
9STK162.20259451
10DYRK32.11704926
11MAP2K72.08916497
12MAP2K32.04614077
13MARK31.99931699
14GRK61.98133219
15PBK1.73217366
16SCYL21.69681177
17IKBKB1.69323925
18BMPR21.67789925
19MAP3K141.66467279
20KSR11.63392476
21IKBKE1.59377787
22NEK91.58603623
23ARAF1.58243919
24MAP3K91.55388453
25FRK1.55118570
26JAK31.53713965
27TBK11.48304428
28BCKDK1.47368108
29MAPK71.45710297
30BRD41.42686212
31ERN11.39339990
32IRAK31.19118926
33PRKD31.18340075
34TNK21.13122671
35CSNK1A1L1.12621919
36MAP2K21.10105045
37CSNK1G31.04921485
38BTK1.01309116
39ZAP701.01021611
40NUAK10.98617262
41TAF10.96877946
42NME10.94368818
43MAP3K50.93509722
44PIM10.92633879
45PDK10.89945856
46CAMK40.89859099
47RPS6KL10.86670408
48RPS6KC10.86670408
49TAOK20.84878757
50MAPK110.83375445
51PIK3CG0.82845634
52LYN0.81261303
53MATK0.80692306
54JAK10.79017174
55PKN10.78706702
56MUSK0.78695671
57GRK70.78211172
58BRSK20.74249941
59PRPF4B0.72504997
60RPS6KA60.72152505
61CSNK1G20.71463667
62MAPK130.70451909
63CSNK1G10.70310443
64AURKA0.69889551
65SMG10.69426232
66RPS6KA50.69011493
67KIT0.68005986
68STK110.67671924
69CSK0.67461141
70LCK0.67361802
71MAP3K40.66770824
72RPS6KA20.64466277
73MAP3K10.63908026
74PIM20.63468871
75HCK0.62319060
76RIPK40.62294675
77SYK0.62288532
78CCNB10.59718895
79STK380.59024954
80RPS6KA40.58817206
81ADRBK20.58579455
82CDK190.57497564
83CHUK0.55811230
84ICK0.55435436
85NEK60.53106098
86MAP3K130.52700568
87RAF10.52556497
88VRK20.51039735
89JAK20.49272899
90MAP3K110.48627384
91KSR20.48537764
92PRKD20.46250409
93VRK10.44950133
94DAPK10.44640626
95CSF1R0.44024152
96TLK10.42626554
97SGK30.41898793
98MAPK40.40879672
99MAP2K40.40854157
100MAP3K70.40835880

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.69212706
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.69123677
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.52519792
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.49487652
5Measles_Homo sapiens_hsa051622.09339594
6Systemic lupus erythematosus_Homo sapiens_hsa053222.05735858
7Osteoclast differentiation_Homo sapiens_hsa043802.04838499
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04271406
9T cell receptor signaling pathway_Homo sapiens_hsa046602.03523826
10Sulfur relay system_Homo sapiens_hsa041222.02941850
11RNA polymerase_Homo sapiens_hsa030202.02410459
12Allograft rejection_Homo sapiens_hsa053302.00060352
13Fanconi anemia pathway_Homo sapiens_hsa034601.97230568
14Herpes simplex infection_Homo sapiens_hsa051681.89047446
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74977515
16B cell receptor signaling pathway_Homo sapiens_hsa046621.73619175
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66116949
18Graft-versus-host disease_Homo sapiens_hsa053321.63023198
19Peroxisome_Homo sapiens_hsa041461.60271937
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.59367760
21Regulation of autophagy_Homo sapiens_hsa041401.59359301
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52875208
23Leishmaniasis_Homo sapiens_hsa051401.51853894
24Autoimmune thyroid disease_Homo sapiens_hsa053201.48898947
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.48033005
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46061175
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.40438511
28Staphylococcus aureus infection_Homo sapiens_hsa051501.36023456
29Hematopoietic cell lineage_Homo sapiens_hsa046401.35457677
30Viral carcinogenesis_Homo sapiens_hsa052031.34167262
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31887359
32Tuberculosis_Homo sapiens_hsa051521.30478591
33Type I diabetes mellitus_Homo sapiens_hsa049401.25957205
34ABC transporters_Homo sapiens_hsa020101.22205031
35Legionellosis_Homo sapiens_hsa051341.19156848
36Influenza A_Homo sapiens_hsa051641.18934728
37TNF signaling pathway_Homo sapiens_hsa046681.16514688
38Steroid biosynthesis_Homo sapiens_hsa001001.16356197
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15959225
40Salmonella infection_Homo sapiens_hsa051321.12930425
41Alcoholism_Homo sapiens_hsa050341.12785171
42Rheumatoid arthritis_Homo sapiens_hsa053231.10179259
43Fatty acid elongation_Homo sapiens_hsa000621.07879583
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06181022
45Inositol phosphate metabolism_Homo sapiens_hsa005621.02954797
46Lysosome_Homo sapiens_hsa041421.00188036
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.98691104
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94642584
49p53 signaling pathway_Homo sapiens_hsa041150.94335870
50Epstein-Barr virus infection_Homo sapiens_hsa051690.91931331
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90921122
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90437446
53African trypanosomiasis_Homo sapiens_hsa051430.89282877
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88960994
55Shigellosis_Homo sapiens_hsa051310.88571223
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88210659
57Malaria_Homo sapiens_hsa051440.87764738
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86930070
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86788524
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85537208
61mTOR signaling pathway_Homo sapiens_hsa041500.84602913
62Hepatitis B_Homo sapiens_hsa051610.83743123
63Pyrimidine metabolism_Homo sapiens_hsa002400.82149244
64Apoptosis_Homo sapiens_hsa042100.81890781
65Base excision repair_Homo sapiens_hsa034100.79777239
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79351028
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78832522
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77811776
69Pertussis_Homo sapiens_hsa051330.77509183
70Chemokine signaling pathway_Homo sapiens_hsa040620.75570767
71FoxO signaling pathway_Homo sapiens_hsa040680.75070482
72Circadian rhythm_Homo sapiens_hsa047100.71393001
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70790679
74Sulfur metabolism_Homo sapiens_hsa009200.69653239
75Endocytosis_Homo sapiens_hsa041440.68284858
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67424719
77Acute myeloid leukemia_Homo sapiens_hsa052210.67145955
78Non-small cell lung cancer_Homo sapiens_hsa052230.66357741
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.66211644
80Hepatitis C_Homo sapiens_hsa051600.65867942
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61493848
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.60901588
83Basal transcription factors_Homo sapiens_hsa030220.60417147
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59569990
85Toxoplasmosis_Homo sapiens_hsa051450.57388171
86Asthma_Homo sapiens_hsa053100.57041862
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.54505458
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52637120
89Butanoate metabolism_Homo sapiens_hsa006500.52383603
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51403208
91Antigen processing and presentation_Homo sapiens_hsa046120.51165548
92N-Glycan biosynthesis_Homo sapiens_hsa005100.49034059
93RNA degradation_Homo sapiens_hsa030180.48722209
94Folate biosynthesis_Homo sapiens_hsa007900.48589885
95Prolactin signaling pathway_Homo sapiens_hsa049170.43851041
96Retinol metabolism_Homo sapiens_hsa008300.43738703
97Phagosome_Homo sapiens_hsa041450.43639730
98Complement and coagulation cascades_Homo sapiens_hsa046100.43573512
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40404106
100Dorso-ventral axis formation_Homo sapiens_hsa043200.39785228

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