C2ORF47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.87797549
2proteasome assembly (GO:0043248)4.75536753
3maturation of SSU-rRNA (GO:0030490)4.51151433
4chaperone-mediated protein transport (GO:0072321)4.44570233
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.31248496
6ATP synthesis coupled proton transport (GO:0015986)4.24117220
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.24117220
8cullin deneddylation (GO:0010388)4.19032170
9ribosomal small subunit biogenesis (GO:0042274)4.15894893
10establishment of integrated proviral latency (GO:0075713)4.08542935
11chromatin remodeling at centromere (GO:0031055)4.05363564
12regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.02019757
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.99540687
14ribosomal small subunit assembly (GO:0000028)3.98279974
15protein deneddylation (GO:0000338)3.97901578
16ribosomal large subunit biogenesis (GO:0042273)3.97536149
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.97337691
18CENP-A containing nucleosome assembly (GO:0034080)3.96829708
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.96761162
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.95609851
21negative regulation of ligase activity (GO:0051352)3.95609851
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.88386755
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.88260566
24regulation of mitochondrial translation (GO:0070129)3.81000101
25establishment of viral latency (GO:0019043)3.76308884
26regulation of cellular amino acid metabolic process (GO:0006521)3.72722132
27formation of translation preinitiation complex (GO:0001731)3.61601086
28pseudouridine synthesis (GO:0001522)3.59815102
29viral transcription (GO:0019083)3.58247040
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.57980335
31termination of RNA polymerase III transcription (GO:0006386)3.57980335
32translational termination (GO:0006415)3.57777573
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56352454
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.55708366
35pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.53775529
36signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.52879397
37signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.52879397
38signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.52879397
39respiratory electron transport chain (GO:0022904)3.51191061
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.50391255
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.50391255
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48945704
43mitochondrial respiratory chain complex assembly (GO:0033108)3.48558672
44purine nucleobase biosynthetic process (GO:0009113)3.48277750
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44446335
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.43353320
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43353320
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.42421597
49DNA replication checkpoint (GO:0000076)3.42238712
50IMP biosynthetic process (GO:0006188)3.40507047
51translation (GO:0006412)3.39565780
52cotranslational protein targeting to membrane (GO:0006613)3.38535134
53protein targeting to mitochondrion (GO:0006626)3.38304510
54signal transduction involved in cell cycle checkpoint (GO:0072395)3.38236491
55electron transport chain (GO:0022900)3.38030300
56ribonucleoprotein complex biogenesis (GO:0022613)3.36912126
57protein targeting to ER (GO:0045047)3.34950418
58positive regulation of ligase activity (GO:0051351)3.34141289
59rRNA processing (GO:0006364)3.33989338
60DNA damage response, detection of DNA damage (GO:0042769)3.32330047
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31234708
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.31234708
63NADH dehydrogenase complex assembly (GO:0010257)3.31234708
64protein complex biogenesis (GO:0070271)3.31020831
65L-serine metabolic process (GO:0006563)3.30878495
66rRNA metabolic process (GO:0016072)3.27900545
67translational initiation (GO:0006413)3.27338721
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26496248
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26496248
70water-soluble vitamin biosynthetic process (GO:0042364)3.23874813
71translational elongation (GO:0006414)3.22950159
72cellular component biogenesis (GO:0044085)3.22893516
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22195669
74rRNA modification (GO:0000154)3.21651685
75protein neddylation (GO:0045116)3.21627664
76histone exchange (GO:0043486)3.21256548
77pyrimidine nucleotide catabolic process (GO:0006244)3.20145623
78oxidative phosphorylation (GO:0006119)3.17830898
79protein localization to endoplasmic reticulum (GO:0070972)3.17089654
80nucleobase biosynthetic process (GO:0046112)3.14005486
81establishment of protein localization to mitochondrion (GO:0072655)3.13937900
82spliceosomal snRNP assembly (GO:0000387)3.13167564
83regulation of ubiquitin-protein transferase activity (GO:0051438)3.13117715
84DNA strand elongation involved in DNA replication (GO:0006271)3.12698707
85mitotic metaphase plate congression (GO:0007080)3.12628192
86protein localization to mitochondrion (GO:0070585)3.08328207
87protein localization to kinetochore (GO:0034501)3.07608406
88regulation of ligase activity (GO:0051340)3.07444924
89ribosome assembly (GO:0042255)3.03732772
90DNA replication-independent nucleosome assembly (GO:0006336)3.02493139
91DNA replication-independent nucleosome organization (GO:0034724)3.02493139
92DNA deamination (GO:0045006)2.98094461
93DNA strand elongation (GO:0022616)2.96390867
94IMP metabolic process (GO:0046040)2.96367621
95transcription from mitochondrial promoter (GO:0006390)2.96051537
96mitochondrial RNA metabolic process (GO:0000959)2.94006252
97ribosome biogenesis (GO:0042254)2.93640585
98base-excision repair, AP site formation (GO:0006285)2.93118306
99viral life cycle (GO:0019058)2.92810989
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91139364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.13758947
2E2F7_22180533_ChIP-Seq_HELA_Human4.94581020
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.26833307
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.19586337
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72446387
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.66845249
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.51936903
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42976779
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36079966
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.35328343
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28448677
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16733751
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.12257400
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00214001
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79344883
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77322407
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71795434
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66925901
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66744358
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42768907
21VDR_23849224_ChIP-Seq_CD4+_Human2.41780673
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39383408
23DCP1A_22483619_ChIP-Seq_HELA_Human2.38953265
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.37880705
25* FOXP3_21729870_ChIP-Seq_TREG_Human2.32767763
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29636921
27XRN2_22483619_ChIP-Seq_HELA_Human2.23085919
28ELK1_19687146_ChIP-ChIP_HELA_Human2.19493430
29* GABP_19822575_ChIP-Seq_HepG2_Human2.19081075
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11396451
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.10696165
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09524744
33TTF2_22483619_ChIP-Seq_HELA_Human2.07128623
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.02991032
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00750997
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99608647
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98964794
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98957026
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93709080
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.87703303
41AR_21909140_ChIP-Seq_LNCAP_Human1.87404734
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81662808
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.79376140
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70152598
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68940945
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68731472
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61312250
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60987834
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59651200
50MYC_18940864_ChIP-ChIP_HL60_Human1.57498166
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56913788
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55305498
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55059322
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42727445
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38953999
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36664732
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31733159
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28495008
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28048875
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27369889
61KDM5A_27292631_Chip-Seq_BREAST_Human1.27170583
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22160980
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16904435
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15968535
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14799156
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11576028
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10264307
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08297605
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07453673
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07256983
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05811653
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05547403
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04937707
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.00539927
75CIITA_25753668_ChIP-Seq_RAJI_Human1.00128090
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98740550
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97806321
78IRF1_19129219_ChIP-ChIP_H3396_Human0.96622402
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96448322
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95942368
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.95178096
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95018518
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.94837145
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.93667832
85VDR_22108803_ChIP-Seq_LS180_Human0.92907008
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.89877402
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88089554
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87211449
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84571141
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83888838
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83257106
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83140577
93TFEB_21752829_ChIP-Seq_HELA_Human0.79357504
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78803216
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76497248
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76125460
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75754045
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75335297
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74450397
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73808231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.28972797
2MP0008058_abnormal_DNA_repair4.15541611
3MP0003806_abnormal_nucleotide_metabolis4.10352693
4MP0004957_abnormal_blastocyst_morpholog3.58283018
5MP0010094_abnormal_chromosome_stability3.48575709
6MP0008007_abnormal_cellular_replicative3.12268706
7MP0003111_abnormal_nucleus_morphology2.99282161
8MP0003186_abnormal_redox_activity2.83421818
9MP0009697_abnormal_copulation2.70910572
10MP0003077_abnormal_cell_cycle2.69741364
11MP0003786_premature_aging2.48658006
12MP0003123_paternal_imprinting2.44050925
13MP0003718_maternal_effect2.34834111
14MP0008932_abnormal_embryonic_tissue2.32840784
15MP0006292_abnormal_olfactory_placode2.31500694
16MP0002139_abnormal_hepatobiliary_system2.29684291
17MP0006036_abnormal_mitochondrial_physio2.25255444
18MP0002163_abnormal_gland_morphology2.16962092
19MP0005085_abnormal_gallbladder_physiolo2.14172853
20MP0008789_abnormal_olfactory_epithelium2.10579147
21MP0008875_abnormal_xenobiotic_pharmacok2.07264697
22MP0006035_abnormal_mitochondrial_morpho2.04309873
23MP0009379_abnormal_foot_pigmentation2.02772943
24MP0001529_abnormal_vocalization1.93165461
25MP0001764_abnormal_homeostasis1.80706386
26MP0003315_abnormal_perineum_morphology1.77187035
27MP0008877_abnormal_DNA_methylation1.67915621
28MP0003941_abnormal_skin_development1.63428149
29MP0005360_urolithiasis1.59706968
30MP0005379_endocrine/exocrine_gland_phen1.51325470
31MP0005394_taste/olfaction_phenotype1.50495472
32MP0005499_abnormal_olfactory_system1.50495472
33MP0006072_abnormal_retinal_apoptosis1.46663281
34MP0001730_embryonic_growth_arrest1.45442322
35MP0002160_abnormal_reproductive_system1.39594440
36MP0002938_white_spotting1.39168768
37MP0005365_abnormal_bile_salt1.36829012
38MP0003011_delayed_dark_adaptation1.36801149
39MP0001293_anophthalmia1.31424675
40MP0005332_abnormal_amino_acid1.30803619
41MP0003195_calcinosis1.26473009
42MP0003890_abnormal_embryonic-extraembry1.22276706
43MP0004133_heterotaxia1.21818035
44MP0000358_abnormal_cell_content/1.20486499
45MP0002638_abnormal_pupillary_reflex1.19431792
46MP0005187_abnormal_penis_morphology1.18505686
47MP0002210_abnormal_sex_determination1.18505082
48MP0005408_hypopigmentation1.17954836
49MP0001697_abnormal_embryo_size1.14459987
50MP0000350_abnormal_cell_proliferation1.13689511
51MP0003567_abnormal_fetal_cardiomyocyte1.12298851
52MP0008057_abnormal_DNA_replication1.10543976
53MP0004147_increased_porphyrin_level1.07366244
54MP0000313_abnormal_cell_death1.06115303
55MP0002736_abnormal_nociception_after1.05472217
56MP0003121_genomic_imprinting1.03286429
57MP0002102_abnormal_ear_morphology1.02736670
58MP0005084_abnormal_gallbladder_morpholo1.01377298
59MP0000647_abnormal_sebaceous_gland0.99746752
60MP0002138_abnormal_hepatobiliary_system0.98126476
61MP0003937_abnormal_limbs/digits/tail_de0.97944219
62MP0009672_abnormal_birth_weight0.97196515
63MP0005389_reproductive_system_phenotype0.96533007
64MP0000372_irregular_coat_pigmentation0.96312891
65MP0000653_abnormal_sex_gland0.96288454
66MP0000490_abnormal_crypts_of0.95230507
67MP0001929_abnormal_gametogenesis0.93528655
68MP0001145_abnormal_male_reproductive0.93254980
69MP0003252_abnormal_bile_duct0.93040008
70MP0010030_abnormal_orbit_morphology0.90253600
71MP0002233_abnormal_nose_morphology0.89631016
72MP0002080_prenatal_lethality0.89297664
73MP0002090_abnormal_vision0.88734598
74MP0001881_abnormal_mammary_gland0.88567285
75MP0005380_embryogenesis_phenotype0.87596009
76MP0001672_abnormal_embryogenesis/_devel0.87596009
77MP0001727_abnormal_embryo_implantation0.82972851
78MP0002085_abnormal_embryonic_tissue0.81240759
79MP0002084_abnormal_developmental_patter0.80096046
80MP0001119_abnormal_female_reproductive0.78936003
81MP0005266_abnormal_metabolism0.78489084
82MP0001666_abnormal_nutrient_absorption0.78460969
83MP0002876_abnormal_thyroid_physiology0.76751552
84MP0002697_abnormal_eye_size0.74946963
85MP0003119_abnormal_digestive_system0.74859552
86MP0005636_abnormal_mineral_homeostasis0.73716418
87MP0003787_abnormal_imprinting0.73350161
88MP0005501_abnormal_skin_physiology0.72011998
89MP0003646_muscle_fatigue0.71836444
90MP0001188_hyperpigmentation0.71724528
91MP0000049_abnormal_middle_ear0.71096687
92MP0003868_abnormal_feces_composition0.71096397
93MP0010386_abnormal_urinary_bladder0.70980661
94MP0001286_abnormal_eye_development0.70189896
95MP0005395_other_phenotype0.68117731
96MP0001324_abnormal_eye_pigmentation0.67057089
97MP0002019_abnormal_tumor_incidence0.66824953
98MP0003984_embryonic_growth_retardation0.66455523
99MP0002234_abnormal_pharynx_morphology0.65208127
100MP0002796_impaired_skin_barrier0.64032366

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.71653087
2Acute encephalopathy (HP:0006846)4.64235901
3Abnormal mitochondria in muscle tissue (HP:0008316)4.44015695
4Increased CSF lactate (HP:0002490)4.02152568
5Mitochondrial inheritance (HP:0001427)3.88445172
6Cerebral edema (HP:0002181)3.81497118
7Hyperglycinemia (HP:0002154)3.77061291
8Progressive macrocephaly (HP:0004481)3.71847177
9Hepatocellular necrosis (HP:0001404)3.51283487
10Increased hepatocellular lipid droplets (HP:0006565)3.48512357
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.43260564
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.43260564
13Increased serum pyruvate (HP:0003542)3.43057884
14Reticulocytopenia (HP:0001896)3.41116286
15Hepatic necrosis (HP:0002605)3.30635281
16Increased serum lactate (HP:0002151)3.21065344
17Lipid accumulation in hepatocytes (HP:0006561)3.20659636
18Microvesicular hepatic steatosis (HP:0001414)3.16664346
19Abnormality of serum amino acid levels (HP:0003112)3.15898859
20Abnormality of glycolysis (HP:0004366)3.15888303
21Lactic acidosis (HP:0003128)3.05280642
22Macrocytic anemia (HP:0001972)3.02853007
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97332500
24Abnormality of cells of the erythroid lineage (HP:0012130)2.95963912
25Colon cancer (HP:0003003)2.95545769
26Increased intramyocellular lipid droplets (HP:0012240)2.93993170
27Generalized aminoaciduria (HP:0002909)2.93450738
28Renal Fanconi syndrome (HP:0001994)2.85275195
29Reduced antithrombin III activity (HP:0001976)2.67671852
30Abnormality of serine family amino acid metabolism (HP:0010894)2.67188166
31Abnormality of glycine metabolism (HP:0010895)2.67188166
32Lethargy (HP:0001254)2.65171368
33Abnormality of alanine metabolism (HP:0010916)2.56521299
34Hyperalaninemia (HP:0003348)2.56521299
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56521299
36Hyperglycinuria (HP:0003108)2.53809682
37Abnormal number of erythroid precursors (HP:0012131)2.53682591
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52003095
39Abnormality of methionine metabolism (HP:0010901)2.48528858
40Exercise intolerance (HP:0003546)2.46044019
41Pallor (HP:0000980)2.41960823
42Increased muscle lipid content (HP:0009058)2.41680769
43Leukodystrophy (HP:0002415)2.39282346
44Respiratory failure (HP:0002878)2.34960271
45Degeneration of anterior horn cells (HP:0002398)2.32231980
46Abnormality of the anterior horn cell (HP:0006802)2.32231980
47Hypobetalipoproteinemia (HP:0003563)2.26003934
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21188862
49Type I transferrin isoform profile (HP:0003642)2.20179399
50Methylmalonic acidemia (HP:0002912)2.20170355
51Pancytopenia (HP:0001876)2.19391846
52Hypoplasia of the pons (HP:0012110)2.17585607
53Abnormal biliary tract physiology (HP:0012439)2.16991134
54Bile duct proliferation (HP:0001408)2.16991134
55Multiple enchondromatosis (HP:0005701)2.13836387
56Methylmalonic aciduria (HP:0012120)2.13605528
57Respiratory difficulties (HP:0002880)2.13135029
58Supernumerary spleens (HP:0009799)2.12683877
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12645348
60Optic disc pallor (HP:0000543)2.05377975
61CNS demyelination (HP:0007305)2.03839582
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03344300
63Abnormal protein N-linked glycosylation (HP:0012347)2.03344300
64Abnormal protein glycosylation (HP:0012346)2.03344300
65Abnormal glycosylation (HP:0012345)2.03344300
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01743208
67Hypoplastic pelvis (HP:0008839)2.00430560
68Abnormal umbilical cord blood vessels (HP:0011403)1.98421968
69Single umbilical artery (HP:0001195)1.98421968
70Abnormality of the fetal cardiovascular system (HP:0010948)1.98421968
71Abnormality of urine glucose concentration (HP:0011016)1.97662452
72Glycosuria (HP:0003076)1.97662452
73Abnormality of the pons (HP:0007361)1.95930979
74Testicular atrophy (HP:0000029)1.95336003
75Cerebral hypomyelination (HP:0006808)1.95083584
76Ragged-red muscle fibers (HP:0003200)1.94611101
77Progressive muscle weakness (HP:0003323)1.93634599
78Prolonged partial thromboplastin time (HP:0003645)1.91597368
793-Methylglutaconic aciduria (HP:0003535)1.91589036
80Aplastic anemia (HP:0001915)1.89408901
81Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88398789
82Abnormal lung lobation (HP:0002101)1.86486344
83Delayed CNS myelination (HP:0002188)1.83558425
84Premature ovarian failure (HP:0008209)1.82396448
85Stenosis of the external auditory canal (HP:0000402)1.82182256
86Hyperphosphaturia (HP:0003109)1.81350132
87Sparse eyelashes (HP:0000653)1.80882624
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80499976
89Nausea (HP:0002018)1.79512284
90Dysphonia (HP:0001618)1.79506575
91Dicarboxylic aciduria (HP:0003215)1.77745077
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77745077
93Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76683847
94Metabolic acidosis (HP:0001942)1.73973508
95Megaloblastic anemia (HP:0001889)1.73309657
96Meckel diverticulum (HP:0002245)1.71082601
97Adrenal hypoplasia (HP:0000835)1.70756252
98Horseshoe kidney (HP:0000085)1.70132522
99X-linked dominant inheritance (HP:0001423)1.69671797
100Microretrognathia (HP:0000308)1.69355183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.49723764
2NME23.37394230
3CDC73.13686251
4VRK23.09076577
5NEK12.93917988
6SRPK12.76099032
7ZAK2.73688113
8TTK2.51422252
9EIF2AK12.44698235
10PBK2.44432657
11PLK42.36828861
12TRIM282.18705782
13MST42.15631486
14STK162.05873903
15EIF2AK31.96931745
16TESK21.90548487
17PLK31.80489818
18VRK11.75616674
19PLK11.70427532
20TSSK61.70202129
21WEE11.68150971
22PDK21.66406827
23BRSK21.61700458
24BCKDK1.60610980
25NME11.55483352
26BRAF1.49337851
27TESK11.46635561
28CDK191.40908976
29MKNK11.33701195
30DYRK31.32921279
31ACVR1B1.30342040
32PIM21.25953387
33LIMK11.23756166
34BMPR1B1.19810647
35AURKB1.19455381
36MKNK21.17560397
37CHEK21.14831304
38SCYL21.14431828
39STK101.11220782
40AURKA1.10574924
41ARAF1.09177848
42DYRK21.08175715
43MAP4K21.07286395
44NEK21.06013790
45BRSK11.05377514
46ATR1.04559926
47MAP2K70.99598255
48KDR0.97315751
49WNK30.96898616
50PRKCI0.96752058
51RPS6KA40.95414136
52NUAK10.93861500
53PLK20.91025173
54WNK40.85229958
55ERBB40.83338445
56CSNK1G30.82034218
57TAF10.80832915
58ABL20.79784755
59MAP3K120.79218386
60TLK10.78881941
61CSNK2A20.73235454
62CDK70.72104418
63CSNK2A10.69309162
64PASK0.67579544
65BCR0.66277752
66CHEK10.65999164
67STK40.65543631
68GRK70.63855244
69CSNK1G10.63661241
70IRAK30.63537506
71DAPK10.62144751
72EIF2AK20.61592194
73MAP3K80.61294549
74ATM0.60836671
75CSNK1G20.60118820
76PAK40.58223155
77ERBB30.57826887
78RPS6KA50.57340509
79STK30.55773544
80TGFBR10.55765563
81FLT30.55424225
82CSNK1A1L0.52604803
83MARK30.52547748
84MST1R0.51343320
85PIM10.50742267
86EPHA20.50505128
87STK38L0.49296368
88AKT20.48723518
89STK240.48078029
90CLK10.46138546
91MAP3K40.46034719
92CSNK1E0.43582412
93PAK10.38190184
94OBSCN0.36760084
95RPS6KB20.36440428
96ALK0.36040516
97CDK20.35145419
98STK390.35028580
99CDK140.34742146
100CDK30.34674035

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.29240114
2Ribosome_Homo sapiens_hsa030103.59475619
3Oxidative phosphorylation_Homo sapiens_hsa001903.08703001
4DNA replication_Homo sapiens_hsa030302.71898376
5Parkinsons disease_Homo sapiens_hsa050122.70479398
6RNA polymerase_Homo sapiens_hsa030202.57499145
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54595508
8Mismatch repair_Homo sapiens_hsa034302.35531333
9Protein export_Homo sapiens_hsa030602.19133553
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15934233
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08106438
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03781898
13Huntingtons disease_Homo sapiens_hsa050161.96959956
14Non-homologous end-joining_Homo sapiens_hsa034501.92881254
15One carbon pool by folate_Homo sapiens_hsa006701.92542909
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91865477
17Base excision repair_Homo sapiens_hsa034101.90575930
18Spliceosome_Homo sapiens_hsa030401.88541014
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87002573
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81679299
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.78679955
22Pyrimidine metabolism_Homo sapiens_hsa002401.77983601
23RNA transport_Homo sapiens_hsa030131.75633370
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67960141
25Alzheimers disease_Homo sapiens_hsa050101.62371457
26Pyruvate metabolism_Homo sapiens_hsa006201.57686126
27Nucleotide excision repair_Homo sapiens_hsa034201.53026926
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49495139
29RNA degradation_Homo sapiens_hsa030181.49214072
30Biosynthesis of amino acids_Homo sapiens_hsa012301.42456581
31Homologous recombination_Homo sapiens_hsa034401.39094698
32Carbon metabolism_Homo sapiens_hsa012001.37797046
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34368336
34Steroid biosynthesis_Homo sapiens_hsa001001.33090018
35Propanoate metabolism_Homo sapiens_hsa006401.32040977
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31563305
37Sulfur relay system_Homo sapiens_hsa041221.31080435
38Cell cycle_Homo sapiens_hsa041101.30955179
39Vitamin B6 metabolism_Homo sapiens_hsa007501.29347120
40Fatty acid elongation_Homo sapiens_hsa000621.25439983
41Basal transcription factors_Homo sapiens_hsa030221.23373253
42Sulfur metabolism_Homo sapiens_hsa009201.21300315
43Fanconi anemia pathway_Homo sapiens_hsa034601.20258139
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.16088507
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.13604370
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13333673
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13315340
48Peroxisome_Homo sapiens_hsa041461.09894707
49Folate biosynthesis_Homo sapiens_hsa007901.06484630
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04975504
51Purine metabolism_Homo sapiens_hsa002301.02657870
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00096982
53Glutathione metabolism_Homo sapiens_hsa004800.99594849
54Selenocompound metabolism_Homo sapiens_hsa004500.95353198
55Fatty acid degradation_Homo sapiens_hsa000710.92515506
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91286970
57Retinol metabolism_Homo sapiens_hsa008300.91153691
58Phenylalanine metabolism_Homo sapiens_hsa003600.90137535
59Metabolic pathways_Homo sapiens_hsa011000.86584862
60Caffeine metabolism_Homo sapiens_hsa002320.85327685
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84825542
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84481849
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83308204
64Chemical carcinogenesis_Homo sapiens_hsa052040.79281438
65Arginine biosynthesis_Homo sapiens_hsa002200.77394261
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76356902
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.75242258
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73921033
69Cardiac muscle contraction_Homo sapiens_hsa042600.72928723
70Arginine and proline metabolism_Homo sapiens_hsa003300.69543719
71Pentose phosphate pathway_Homo sapiens_hsa000300.66800719
72Tryptophan metabolism_Homo sapiens_hsa003800.65868793
73Fatty acid metabolism_Homo sapiens_hsa012120.63561046
74Tyrosine metabolism_Homo sapiens_hsa003500.63120632
75Butanoate metabolism_Homo sapiens_hsa006500.61022365
76p53 signaling pathway_Homo sapiens_hsa041150.60095158
77Systemic lupus erythematosus_Homo sapiens_hsa053220.58782355
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57082245
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53052418
80mRNA surveillance pathway_Homo sapiens_hsa030150.52814020
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50635400
82Collecting duct acid secretion_Homo sapiens_hsa049660.48703244
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.48244598
84beta-Alanine metabolism_Homo sapiens_hsa004100.44108126
85Fat digestion and absorption_Homo sapiens_hsa049750.42377739
86Fructose and mannose metabolism_Homo sapiens_hsa000510.40822416
87Epstein-Barr virus infection_Homo sapiens_hsa051690.39686093
88Starch and sucrose metabolism_Homo sapiens_hsa005000.39445305
89Galactose metabolism_Homo sapiens_hsa000520.39378428
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37112699
91Oocyte meiosis_Homo sapiens_hsa041140.33383752
92N-Glycan biosynthesis_Homo sapiens_hsa005100.26434049
93Regulation of autophagy_Homo sapiens_hsa041400.26337082
94Vitamin digestion and absorption_Homo sapiens_hsa049770.26328857
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25894144
96Phototransduction_Homo sapiens_hsa047440.25114860
97Vibrio cholerae infection_Homo sapiens_hsa051100.21191013
98Alcoholism_Homo sapiens_hsa050340.17415070
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17300566
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15384283

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