C2ORF49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)4.01088862
2ribonucleoprotein complex disassembly (GO:0032988)3.75817953
3centriole replication (GO:0007099)3.57511901
4V(D)J recombination (GO:0033151)3.44313242
5organelle disassembly (GO:1903008)3.40584078
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38323252
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34572205
8resolution of meiotic recombination intermediates (GO:0000712)3.22913492
9response to pheromone (GO:0019236)3.21658908
10protein-cofactor linkage (GO:0018065)3.20666100
11nonmotile primary cilium assembly (GO:0035058)3.20664403
12transcription elongation from RNA polymerase I promoter (GO:0006362)3.19491743
13rRNA methylation (GO:0031167)3.14450211
14protein K11-linked deubiquitination (GO:0035871)3.13084881
15prenylation (GO:0097354)3.12772068
16protein prenylation (GO:0018342)3.12772068
17mitotic sister chromatid cohesion (GO:0007064)3.09745331
18negative regulation of DNA recombination (GO:0045910)3.01903049
19behavioral response to nicotine (GO:0035095)2.99927903
20spermatid nucleus differentiation (GO:0007289)2.99813853
21positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.92689217
22mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.92689217
23pseudouridine synthesis (GO:0001522)2.91048977
24water-soluble vitamin biosynthetic process (GO:0042364)2.89377756
25negative regulation of oligodendrocyte differentiation (GO:0048715)2.87858232
26respiratory chain complex IV assembly (GO:0008535)2.86354549
27transcription elongation from RNA polymerase III promoter (GO:0006385)2.86216469
28termination of RNA polymerase III transcription (GO:0006386)2.86216469
29termination of RNA polymerase I transcription (GO:0006363)2.85693472
307-methylguanosine mRNA capping (GO:0006370)2.83853800
31regulation of centriole replication (GO:0046599)2.80316311
32histone H2A ubiquitination (GO:0033522)2.80008660
33epithelial cilium movement (GO:0003351)2.80008268
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79864287
35rRNA modification (GO:0000154)2.76382207
36spliceosomal complex assembly (GO:0000245)2.75692973
37microtubule anchoring (GO:0034453)2.74789146
387-methylguanosine RNA capping (GO:0009452)2.73747856
39RNA capping (GO:0036260)2.73747856
40establishment of protein localization to Golgi (GO:0072600)2.72941246
41cellular response to ethanol (GO:0071361)2.70760642
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.68930279
43CENP-A containing nucleosome assembly (GO:0034080)2.68213911
44protein targeting to Golgi (GO:0000042)2.68202135
45double-strand break repair via homologous recombination (GO:0000724)2.67514869
46replication fork processing (GO:0031297)2.66688519
47alternative mRNA splicing, via spliceosome (GO:0000380)2.65826390
48transcription from RNA polymerase III promoter (GO:0006383)2.65799732
49chromatin remodeling at centromere (GO:0031055)2.64838356
50mitochondrial respiratory chain complex assembly (GO:0033108)2.64738874
51microtubule nucleation (GO:0007020)2.64695990
52respiratory electron transport chain (GO:0022904)2.63988527
53recombinational repair (GO:0000725)2.63929148
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63919135
55somatic diversification of immune receptors (GO:0002200)2.63827099
56somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63260235
57somatic hypermutation of immunoglobulin genes (GO:0016446)2.63260235
58cilium movement (GO:0003341)2.63201143
59protein complex biogenesis (GO:0070271)2.62630822
60mitochondrial respiratory chain complex I assembly (GO:0032981)2.61457942
61NADH dehydrogenase complex assembly (GO:0010257)2.61457942
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61457942
63histone mRNA metabolic process (GO:0008334)2.59726243
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.59722313
65cilium or flagellum-dependent cell motility (GO:0001539)2.59258642
66electron transport chain (GO:0022900)2.58496982
67rRNA catabolic process (GO:0016075)2.56957884
68neural tube formation (GO:0001841)2.56655171
69ribosomal large subunit biogenesis (GO:0042273)2.56239069
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55920223
71transcription initiation from RNA polymerase I promoter (GO:0006361)2.53599409
72DNA double-strand break processing (GO:0000729)2.53487888
73intraciliary transport (GO:0042073)2.53351079
74anterograde synaptic vesicle transport (GO:0048490)2.53314776
75DNA topological change (GO:0006265)2.52897074
76replicative senescence (GO:0090399)2.52548818
77somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.51893974
78somatic cell DNA recombination (GO:0016444)2.51893974
79ATP synthesis coupled proton transport (GO:0015986)2.51149647
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.51149647
81maturation of 5.8S rRNA (GO:0000460)2.49728901
82histone H2A monoubiquitination (GO:0035518)2.48700443
83ribosome assembly (GO:0042255)2.48316104
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47203050
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47203050
86mitochondrial RNA metabolic process (GO:0000959)2.46639163
87positive regulation of mRNA processing (GO:0050685)2.46112020
88positive regulation of histone H3-K4 methylation (GO:0051571)2.44795293
89ncRNA catabolic process (GO:0034661)2.44654158
90peptidyl-histidine modification (GO:0018202)2.44350959
91attachment of spindle microtubules to kinetochore (GO:0008608)2.43738772
92regulation of acyl-CoA biosynthetic process (GO:0050812)2.40625322
93centriole assembly (GO:0098534)2.40198457
94transcription elongation from RNA polymerase II promoter (GO:0006368)2.39998178
95histone monoubiquitination (GO:0010390)2.38658752
96pyrimidine dimer repair (GO:0006290)2.37393531
97retrograde transport, vesicle recycling within Golgi (GO:0000301)2.34400387
98histone exchange (GO:0043486)2.33967497
99histone ubiquitination (GO:0016574)2.33733817
100tRNA processing (GO:0008033)2.32491833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.80258119
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.03058142
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98088848
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.93437683
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86846126
6ELK1_19687146_ChIP-ChIP_HELA_Human2.70942710
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.70725540
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65865480
9FUS_26573619_Chip-Seq_HEK293_Human2.60922229
10EWS_26573619_Chip-Seq_HEK293_Human2.55428901
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44664827
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37686566
13ZNF274_21170338_ChIP-Seq_K562_Hela2.33769162
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29663465
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22812914
16TAF15_26573619_Chip-Seq_HEK293_Human2.19578749
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.12199969
18VDR_23849224_ChIP-Seq_CD4+_Human2.08999555
19IGF1R_20145208_ChIP-Seq_DFB_Human2.05880123
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02914709
21E2F7_22180533_ChIP-Seq_HELA_Human2.02807380
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98944902
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94106313
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.93967841
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91787312
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89089580
27VDR_22108803_ChIP-Seq_LS180_Human1.88498475
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87651789
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74395147
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.73458485
31GBX2_23144817_ChIP-Seq_PC3_Human1.72277740
32FOXP3_21729870_ChIP-Seq_TREG_Human1.70779533
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.70720375
34P300_19829295_ChIP-Seq_ESCs_Human1.68804709
35ER_23166858_ChIP-Seq_MCF-7_Human1.67846244
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63648822
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58661820
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53518938
39EZH2_22144423_ChIP-Seq_EOC_Human1.49694397
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49276247
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44207392
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43704397
43IRF1_19129219_ChIP-ChIP_H3396_Human1.41018922
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40766500
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30159752
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29694880
47TP53_22573176_ChIP-Seq_HFKS_Human1.28561295
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28431729
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26318949
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25621676
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24968718
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22415806
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.22090454
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21940409
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21658064
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21387454
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20851320
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.20518310
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19401275
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.18133695
61MYC_18940864_ChIP-ChIP_HL60_Human1.17579358
62SMAD4_21799915_ChIP-Seq_A2780_Human1.16717758
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.16211769
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14660073
65TTF2_22483619_ChIP-Seq_HELA_Human1.14402074
66CBP_20019798_ChIP-Seq_JUKART_Human1.14231919
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14231919
68STAT3_23295773_ChIP-Seq_U87_Human1.12666450
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.11629505
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09942448
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09781012
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.09489121
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08638888
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08132761
75DCP1A_22483619_ChIP-Seq_HELA_Human1.07438178
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04273500
77NANOG_19829295_ChIP-Seq_ESCs_Human1.03473146
78SOX2_19829295_ChIP-Seq_ESCs_Human1.03473146
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02784774
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.02390564
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.02138339
82P53_22387025_ChIP-Seq_ESCs_Mouse1.01723949
83TCF4_23295773_ChIP-Seq_U87_Human1.01212903
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00152116
85CMYC_18555785_Chip-Seq_ESCs_Mouse0.99728991
86P300_18555785_Chip-Seq_ESCs_Mouse0.99547155
87E2F1_21310950_ChIP-Seq_MCF-7_Human0.98931909
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98784162
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.98144380
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96843888
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.96420879
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94778968
93TCF4_22108803_ChIP-Seq_LS180_Human0.94265938
94SALL4_22934838_ChIP-ChIP_CD34+_Human0.94056013
95SRF_21415370_ChIP-Seq_HL-1_Mouse0.93928168
96RUNX2_22187159_ChIP-Seq_PCA_Human0.93484935
97NMYC_18555785_Chip-Seq_ESCs_Mouse0.93000028
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92599847
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.92251303
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.92175199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.19375907
2MP0010094_abnormal_chromosome_stability2.68650136
3MP0004147_increased_porphyrin_level2.64145289
4MP0003122_maternal_imprinting2.61040996
5MP0000569_abnormal_digit_pigmentation2.57298382
6MP0008877_abnormal_DNA_methylation2.45491858
7MP0003890_abnormal_embryonic-extraembry2.23496941
8MP0002938_white_spotting2.13245706
9MP0002102_abnormal_ear_morphology2.12308578
10MP0008995_early_reproductive_senescence2.05165923
11MP0002638_abnormal_pupillary_reflex1.99770950
12MP0008058_abnormal_DNA_repair1.93084417
13MP0003121_genomic_imprinting1.91848766
14MP0009697_abnormal_copulation1.90987124
15MP0004142_abnormal_muscle_tone1.90775484
16MP0006292_abnormal_olfactory_placode1.86520112
17MP0002132_abnormal_respiratory_system1.85961021
18MP0001984_abnormal_olfaction1.85207942
19MP0002009_preneoplasia1.75849276
20MP0001293_anophthalmia1.73762809
21MP0000372_irregular_coat_pigmentation1.72884732
22MP0001529_abnormal_vocalization1.71700978
23MP0006072_abnormal_retinal_apoptosis1.67858127
24MP0005253_abnormal_eye_physiology1.66856509
25MP0002095_abnormal_skin_pigmentation1.57610131
26MP0005551_abnormal_eye_electrophysiolog1.56581067
27MP0002876_abnormal_thyroid_physiology1.54716923
28MP0004957_abnormal_blastocyst_morpholog1.50980249
29MP0005379_endocrine/exocrine_gland_phen1.50956803
30MP0009046_muscle_twitch1.44364913
31MP0000631_abnormal_neuroendocrine_gland1.43362885
32MP0004215_abnormal_myocardial_fiber1.38340096
33MP0004084_abnormal_cardiac_muscle1.34240333
34MP0005075_abnormal_melanosome_morpholog1.33263282
35MP0003646_muscle_fatigue1.31269435
36MP0003567_abnormal_fetal_cardiomyocyte1.29306592
37MP0003221_abnormal_cardiomyocyte_apopto1.28289042
38MP0002160_abnormal_reproductive_system1.28223505
39MP0003787_abnormal_imprinting1.27783031
40MP0006036_abnormal_mitochondrial_physio1.25324202
41MP0000427_abnormal_hair_cycle1.25228337
42MP0003077_abnormal_cell_cycle1.25191068
43MP0006035_abnormal_mitochondrial_morpho1.22938800
44MP0005410_abnormal_fertilization1.21397060
45MP0001286_abnormal_eye_development1.18944601
46MP0005645_abnormal_hypothalamus_physiol1.17653597
47MP0008872_abnormal_physiological_respon1.17205388
48MP0005391_vision/eye_phenotype1.14041684
49MP0001486_abnormal_startle_reflex1.12679860
50MP0001929_abnormal_gametogenesis1.12410501
51MP0002233_abnormal_nose_morphology1.08786134
52MP0003937_abnormal_limbs/digits/tail_de1.07439813
53MP0002837_dystrophic_cardiac_calcinosis1.06717069
54MP0002166_altered_tumor_susceptibility1.06082999
55MP0002006_tumorigenesis1.04315175
56MP0003718_maternal_effect1.03891749
57MP0003786_premature_aging1.03624498
58MP0001697_abnormal_embryo_size1.02156269
59MP0003111_abnormal_nucleus_morphology0.99768844
60MP0000778_abnormal_nervous_system0.99357780
61MP0002210_abnormal_sex_determination0.96749560
62MP0003880_abnormal_central_pattern0.96059660
63MP0003698_abnormal_male_reproductive0.94390939
64MP0004742_abnormal_vestibular_system0.93733512
65MP0004133_heterotaxia0.93115742
66MP0000647_abnormal_sebaceous_gland0.91363312
67MP0005195_abnormal_posterior_eye0.90956522
68MP0009745_abnormal_behavioral_response0.90851918
69MP0008789_abnormal_olfactory_epithelium0.89811332
70MP0002163_abnormal_gland_morphology0.88814341
71MP0002088_abnormal_embryonic_growth/wei0.87624399
72MP0003136_yellow_coat_color0.87179495
73MP0005389_reproductive_system_phenotype0.86599432
74MP0003984_embryonic_growth_retardation0.86394621
75MP0004197_abnormal_fetal_growth/weight/0.85497892
76MP0002928_abnormal_bile_duct0.84914560
77MP0001879_abnormal_lymphatic_vessel0.83374399
78MP0000653_abnormal_sex_gland0.81652696
79MP0002084_abnormal_developmental_patter0.81534131
80MP0005084_abnormal_gallbladder_morpholo0.81278229
81MP0004885_abnormal_endolymph0.81091605
82MP0002067_abnormal_sensory_capabilities0.80640069
83MP0001919_abnormal_reproductive_system0.80448543
84MP0003950_abnormal_plasma_membrane0.78695345
85MP0001324_abnormal_eye_pigmentation0.77725111
86MP0002127_abnormal_cardiovascular_syste0.77235248
87MP0005380_embryogenesis_phenotype0.77231234
88MP0001672_abnormal_embryogenesis/_devel0.77231234
89MP0003693_abnormal_embryo_hatching0.76516630
90MP0001145_abnormal_male_reproductive0.75957524
91MP0003186_abnormal_redox_activity0.74890261
92MP0005266_abnormal_metabolism0.74206172
93MP0003755_abnormal_palate_morphology0.74032709
94MP0003861_abnormal_nervous_system0.73536377
95MP0003195_calcinosis0.72864455
96MP0002092_abnormal_eye_morphology0.72705363
97MP0003935_abnormal_craniofacial_develop0.72591814
98MP0002184_abnormal_innervation0.72353618
99MP0002277_abnormal_respiratory_mucosa0.72162183
100MP0002090_abnormal_vision0.71071078

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.70317467
2Abnormality of B cell number (HP:0010975)4.16135666
3Hypoplasia of the thymus (HP:0000778)3.80808663
4Increased hepatocellular lipid droplets (HP:0006565)3.30476945
5Thyroiditis (HP:0100646)3.29564685
6Severe combined immunodeficiency (HP:0004430)3.17354695
7Medial flaring of the eyebrow (HP:0010747)3.12057637
8Lipid accumulation in hepatocytes (HP:0006561)2.95928861
9Progressive macrocephaly (HP:0004481)2.71912337
10Acute necrotizing encephalopathy (HP:0006965)2.69694806
11Abnormality of midbrain morphology (HP:0002418)2.67151048
12Molar tooth sign on MRI (HP:0002419)2.67151048
13Papillary thyroid carcinoma (HP:0002895)2.63996074
14Pancreatic cysts (HP:0001737)2.63898858
15Panhypogammaglobulinemia (HP:0003139)2.59226499
16Hypoproteinemia (HP:0003075)2.56401910
17Gait imbalance (HP:0002141)2.55661951
18Chronic hepatic failure (HP:0100626)2.54192160
19Congenital primary aphakia (HP:0007707)2.51455767
20Methylmalonic acidemia (HP:0002912)2.45791764
213-Methylglutaconic aciduria (HP:0003535)2.43874010
22Nephrogenic diabetes insipidus (HP:0009806)2.43723551
23Pancreatic fibrosis (HP:0100732)2.38628980
24Abnormality of alanine metabolism (HP:0010916)2.37899480
25Hyperalaninemia (HP:0003348)2.37899480
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37899480
27Combined immunodeficiency (HP:0005387)2.36396876
28Mitochondrial inheritance (HP:0001427)2.34729361
29Acute encephalopathy (HP:0006846)2.30554343
30Increased CSF lactate (HP:0002490)2.30074495
31Nephronophthisis (HP:0000090)2.28486187
32Neuroendocrine neoplasm (HP:0100634)2.25103017
33Renal Fanconi syndrome (HP:0001994)2.17521312
34Genital tract atresia (HP:0001827)2.17093100
35Poor coordination (HP:0002370)2.16455991
36Renal cortical cysts (HP:0000803)2.15529243
37Thyroid carcinoma (HP:0002890)2.14849894
38Abnormal mitochondria in muscle tissue (HP:0008316)2.14373299
39Abnormality of chromosome stability (HP:0003220)2.14292464
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14247836
41Abnormality of the pons (HP:0007361)2.12612424
42Vaginal atresia (HP:0000148)2.11037746
43Pheochromocytoma (HP:0002666)2.08887089
44Volvulus (HP:0002580)2.07202193
45Abnormality of the labia minora (HP:0012880)2.07190157
46Pancreatic islet-cell hyperplasia (HP:0004510)2.07049707
47Atonic seizures (HP:0010819)2.02768282
48Sensory axonal neuropathy (HP:0003390)2.02420040
49True hermaphroditism (HP:0010459)2.01885451
50Median cleft lip (HP:0000161)1.96229319
51Chromsome breakage (HP:0040012)1.95052280
52Abnormality of the septum pellucidum (HP:0007375)1.94996704
53Homocystinuria (HP:0002156)1.94843574
54Abnormality of homocysteine metabolism (HP:0010919)1.94843574
55Birth length less than 3rd percentile (HP:0003561)1.94582760
56Febrile seizures (HP:0002373)1.94514788
57Abnormality of the renal cortex (HP:0011035)1.93008979
58Erythroderma (HP:0001019)1.91887965
59Rhabdomyosarcoma (HP:0002859)1.90043416
60Constricted visual fields (HP:0001133)1.88192990
61Abnormality of cells of the erythroid lineage (HP:0012130)1.86318112
62Abnormality of the ileum (HP:0001549)1.86059352
63Abnormality of the renal medulla (HP:0100957)1.85876052
64Hypoplasia of the pons (HP:0012110)1.84391743
65Medulloblastoma (HP:0002885)1.84335429
66Biliary tract neoplasm (HP:0100574)1.83496421
67Nephroblastoma (Wilms tumor) (HP:0002667)1.83199287
68Abnormality of methionine metabolism (HP:0010901)1.82931161
69Meckel diverticulum (HP:0002245)1.81866812
70Supernumerary spleens (HP:0009799)1.80874201
71Eosinophilia (HP:0001880)1.79801262
72Abnormal ciliary motility (HP:0012262)1.78359502
73Attenuation of retinal blood vessels (HP:0007843)1.77771411
74Abnormal biliary tract morphology (HP:0012440)1.76950710
75Increased serum lactate (HP:0002151)1.76637322
76Abnormal hemoglobin (HP:0011902)1.75115845
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74482583
78Hypothermia (HP:0002045)1.74379388
79Exertional dyspnea (HP:0002875)1.72228804
80Stenosis of the external auditory canal (HP:0000402)1.70478695
81Embryonal renal neoplasm (HP:0011794)1.68909959
82Abnormality of eosinophils (HP:0001879)1.67048349
83Abnormality of the pancreatic islet cells (HP:0006476)1.65900673
84Abnormality of endocrine pancreas physiology (HP:0012093)1.65900673
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.65170978
86Tubulointerstitial nephritis (HP:0001970)1.64813825
87Cerebellar dysplasia (HP:0007033)1.64767822
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.64637638
89Intestinal atresia (HP:0011100)1.64503955
90Prominent nasal bridge (HP:0000426)1.64463267
91T lymphocytopenia (HP:0005403)1.62822698
92Hepatic necrosis (HP:0002605)1.62649631
93Optic disc pallor (HP:0000543)1.62572295
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62173781
95Hypoglycemic coma (HP:0001325)1.61622063
96Cerebral edema (HP:0002181)1.60567837
97Hepatoblastoma (HP:0002884)1.59841994
98Hepatocellular necrosis (HP:0001404)1.59656606
99Absent septum pellucidum (HP:0001331)1.58734328
100Absent thumb (HP:0009777)1.58135854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.36379493
2EIF2AK33.22576528
3BRD42.76101487
4EIF2AK12.75261365
5MAP4K22.48501624
6BRSK22.42951059
7FRK2.39399610
8BMPR1B2.38800424
9PNCK2.18014082
10SRPK12.17877886
11TNIK2.09557953
12PINK12.09438947
13ERBB32.07206729
14STK162.06614781
15INSRR2.06420929
16MAP3K121.91567345
17PBK1.86583231
18ZAK1.83959072
19MKNK21.83485267
20WNK31.76704275
21MAP3K41.66205817
22DYRK31.60948446
23MKNK11.50344251
24WEE11.31102733
25TAOK31.30026964
26WNK41.25855500
27AKT31.23195949
28TRIM281.21759973
29NUAK11.21117659
30BCR1.19096065
31CDC71.14793863
32MAPK131.13106948
33MAP3K21.05860494
34PLK31.04871627
35SGK21.01530858
36PLK41.01432048
37ACVR1B1.00004781
38YES10.98349339
39LATS10.97927896
40OBSCN0.96890180
41NLK0.96064915
42NEK10.93642618
43STK38L0.93533840
44CAMKK20.91867674
45CASK0.87754472
46KSR10.87134867
47PLK20.85795218
48RPS6KA40.85659956
49WNK10.83830702
50RPS6KB10.82174128
51TSSK60.76799043
52MAP2K40.76116340
53PLK10.74032994
54VRK10.71878880
55STK30.69922560
56SGK2230.64830642
57SGK4940.64830642
58CSNK1G10.64706956
59FGFR10.64346306
60FGFR20.63603899
61CSNK1E0.62020071
62PAK30.60541324
63ATR0.60129133
64CDK90.60060329
65NTRK30.59962746
66STK390.58407283
67CHEK20.58384367
68CDK30.57602363
69ATM0.57304714
70CHEK10.57244678
71NEK90.56188394
72NTRK20.55312147
73PRKCE0.53721420
74DYRK20.51526290
75TTK0.51391023
76PRKAA20.50636303
77SGK10.50312336
78MARK10.48596904
79PRKACB0.48275321
80PHKG20.48255481
81PHKG10.48255481
82DYRK1B0.47072016
83TLK10.45609958
84PRKAA10.45083724
85CSNK1A1L0.44454788
86PRKG10.44171108
87OXSR10.43003708
88RPS6KA50.41989543
89PRKCG0.41481860
90SGK30.40792343
91CSNK1D0.40454741
92RAF10.39650099
93UHMK10.39590296
94TAF10.39054552
95CSNK1G20.38846430
96ADRBK20.38312181
97TEC0.38092657
98TRPM70.37014302
99RPS6KB20.36902627
100EPHA40.35802861

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.96395028
2Basal transcription factors_Homo sapiens_hsa030223.34796764
3Non-homologous end-joining_Homo sapiens_hsa034503.16080779
4Oxidative phosphorylation_Homo sapiens_hsa001903.03238153
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97613152
6RNA polymerase_Homo sapiens_hsa030202.96605181
7Parkinsons disease_Homo sapiens_hsa050122.65485568
8Ribosome_Homo sapiens_hsa030102.56384458
9Homologous recombination_Homo sapiens_hsa034402.54826307
10Fanconi anemia pathway_Homo sapiens_hsa034602.45384725
11RNA degradation_Homo sapiens_hsa030182.30305914
12RNA transport_Homo sapiens_hsa030132.25106956
13Huntingtons disease_Homo sapiens_hsa050162.09716830
14Mismatch repair_Homo sapiens_hsa034302.03447920
15Circadian rhythm_Homo sapiens_hsa047102.01534672
16Spliceosome_Homo sapiens_hsa030401.98720808
17Nucleotide excision repair_Homo sapiens_hsa034201.93910881
18Regulation of autophagy_Homo sapiens_hsa041401.92244818
19Alzheimers disease_Homo sapiens_hsa050101.76332747
20Propanoate metabolism_Homo sapiens_hsa006401.72331031
21mRNA surveillance pathway_Homo sapiens_hsa030151.71106543
22Cardiac muscle contraction_Homo sapiens_hsa042601.62686252
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62595788
24Nicotine addiction_Homo sapiens_hsa050331.59236865
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49509860
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47053428
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42677158
28One carbon pool by folate_Homo sapiens_hsa006701.42556615
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42524825
30Selenocompound metabolism_Homo sapiens_hsa004501.41183626
31Proteasome_Homo sapiens_hsa030501.39626697
32Olfactory transduction_Homo sapiens_hsa047401.34454730
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.27179457
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15788816
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07178586
36Taste transduction_Homo sapiens_hsa047421.04662935
37Phototransduction_Homo sapiens_hsa047441.03784296
38Cell cycle_Homo sapiens_hsa041101.02988261
39Butanoate metabolism_Homo sapiens_hsa006501.00216074
40DNA replication_Homo sapiens_hsa030300.98630858
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95500668
42Nitrogen metabolism_Homo sapiens_hsa009100.95484040
43Steroid biosynthesis_Homo sapiens_hsa001000.95058078
44Alcoholism_Homo sapiens_hsa050340.91084263
45Purine metabolism_Homo sapiens_hsa002300.90120754
46GABAergic synapse_Homo sapiens_hsa047270.81687114
47p53 signaling pathway_Homo sapiens_hsa041150.81050137
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80220996
49Pyrimidine metabolism_Homo sapiens_hsa002400.79597761
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74305580
51Morphine addiction_Homo sapiens_hsa050320.74301603
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73360050
53Oocyte meiosis_Homo sapiens_hsa041140.73274336
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72802814
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.69829806
56Hedgehog signaling pathway_Homo sapiens_hsa043400.69547894
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68816700
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65515172
59Dorso-ventral axis formation_Homo sapiens_hsa043200.62737887
60Ether lipid metabolism_Homo sapiens_hsa005650.59693060
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59158531
62FoxO signaling pathway_Homo sapiens_hsa040680.58199407
63Collecting duct acid secretion_Homo sapiens_hsa049660.57510088
64Peroxisome_Homo sapiens_hsa041460.57492895
65Serotonergic synapse_Homo sapiens_hsa047260.56063429
66Renal cell carcinoma_Homo sapiens_hsa052110.55942970
67Linoleic acid metabolism_Homo sapiens_hsa005910.55353821
68Wnt signaling pathway_Homo sapiens_hsa043100.50084664
69Dopaminergic synapse_Homo sapiens_hsa047280.48872036
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48416654
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48129686
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47880052
73Glutamatergic synapse_Homo sapiens_hsa047240.47864982
74Metabolic pathways_Homo sapiens_hsa011000.45520359
75TGF-beta signaling pathway_Homo sapiens_hsa043500.44162324
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41723983
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41483008
78Pyruvate metabolism_Homo sapiens_hsa006200.41178676
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39468544
80Inositol phosphate metabolism_Homo sapiens_hsa005620.38650213
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35914378
82Fatty acid biosynthesis_Homo sapiens_hsa000610.35861366
83Mineral absorption_Homo sapiens_hsa049780.34715636
84Circadian entrainment_Homo sapiens_hsa047130.28049998
85Systemic lupus erythematosus_Homo sapiens_hsa053220.27527347
86Thyroid cancer_Homo sapiens_hsa052160.26503977
87Colorectal cancer_Homo sapiens_hsa052100.25959845
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25320256
89Cocaine addiction_Homo sapiens_hsa050300.24752164
90Primary immunodeficiency_Homo sapiens_hsa053400.24606062
91Basal cell carcinoma_Homo sapiens_hsa052170.23778536
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23387576
93Caffeine metabolism_Homo sapiens_hsa002320.22417446
94Base excision repair_Homo sapiens_hsa034100.21427985
95Cholinergic synapse_Homo sapiens_hsa047250.20237493
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19169241
97Long-term depression_Homo sapiens_hsa047300.18542288
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17800330
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17700809
100Epstein-Barr virus infection_Homo sapiens_hsa051690.17597909

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