ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.44442501
2	DNA methylation involved in gamete generation (GO:0043046)	4.33028637
3	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.31907992
4	cilium or flagellum-dependent cell motility (GO:0001539)	4.04848924
5	tachykinin receptor signaling pathway (GO:0007217)	3.95235717
6	male meiosis (GO:0007140)	3.86890421
7	male meiosis I (GO:0007141)	3.80641708
8	epithelial cilium movement (GO:0003351)	3.68301630
9	amino acid salvage (GO:0043102)	3.62447126
10	L-methionine salvage (GO:0071267)	3.62447126
11	L-methionine biosynthetic process (GO:0071265)	3.62447126
12	regulation of cilium movement (GO:0003352)	3.60897482
13	DNA double-strand break processing (GO:0000729)	3.60242042
14	mannosylation (GO:0097502)	3.59542033
15	photoreceptor cell maintenance (GO:0045494)	3.53745025
16	meiosis I (GO:0007127)	3.43879291
17	synapsis (GO:0007129)	3.43850060
18	retinal cone cell development (GO:0046549)	3.41336017
19	indolalkylamine metabolic process (GO:0006586)	3.38461729
20	cilium movement (GO:0003341)	3.37457100
21	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.32090916
22	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.32090916
23	neural tube formation (GO:0001841)	3.31410408
24	organic cation transport (GO:0015695)	3.29943448
25	regulation of meiosis I (GO:0060631)	3.29744057
26	DNA deamination (GO:0045006)	3.29380641
27	DNA integration (GO:0015074)	3.28515044
28	axoneme assembly (GO:0035082)	3.27682818
29	multicellular organism reproduction (GO:0032504)	3.21117637
30	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.18366494
31	peptidyl-histidine modification (GO:0018202)	3.17456775
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.13931076
33	protein localization to cilium (GO:0061512)	3.12209439
34	behavioral response to nicotine (GO:0035095)	3.10954888
35	histone H2A acetylation (GO:0043968)	3.09852817
36	GPI anchor metabolic process (GO:0006505)	3.07932559
37	positive regulation of mitochondrial membrane permeability (GO:0035794)	3.04890945
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.04182332
39	L-fucose catabolic process (GO:0042355)	3.01747489
40	fucose catabolic process (GO:0019317)	3.01747489
41	L-fucose metabolic process (GO:0042354)	3.01747489
42	regulation of hippo signaling (GO:0035330)	3.00123380
43	growth hormone secretion (GO:0030252)	2.99344989
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.98119393
45	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.98119393
46	reciprocal DNA recombination (GO:0035825)	2.97263314
47	reciprocal meiotic recombination (GO:0007131)	2.97263314
48	respiratory chain complex IV assembly (GO:0008535)	2.96128543
49	resolution of meiotic recombination intermediates (GO:0000712)	2.95482405
50	xenobiotic catabolic process (GO:0042178)	2.93950225
51	intraciliary transport (GO:0042073)	2.93159966
52	sperm motility (GO:0030317)	2.87533876
53	nonmotile primary cilium assembly (GO:0035058)	2.86024901
54	methionine biosynthetic process (GO:0009086)	2.85053693
55	protein K11-linked deubiquitination (GO:0035871)	2.84785671
56	protein neddylation (GO:0045116)	2.83032876
57	cilium organization (GO:0044782)	2.82434187
58	cilium morphogenesis (GO:0060271)	2.82409642
59	gene silencing by RNA (GO:0031047)	2.82085028
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.79431958
61	detection of light stimulus involved in sensory perception (GO:0050962)	2.79184723
62	detection of light stimulus involved in visual perception (GO:0050908)	2.79184723
63	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.78029937
64	double-strand break repair via homologous recombination (GO:0000724)	2.76709054
65	cilium assembly (GO:0042384)	2.75830773
66	recombinational repair (GO:0000725)	2.74472260
67	GMP metabolic process (GO:0046037)	2.73493569
68	cullin deneddylation (GO:0010388)	2.73422569
69	tryptophan metabolic process (GO:0006568)	2.72290880
70	negative regulation of mast cell activation (GO:0033004)	2.71921746
71	spermatid development (GO:0007286)	2.70568368
72	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.70536604
73	proteasome assembly (GO:0043248)	2.70260583
74	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.68986528
75	sperm-egg recognition (GO:0035036)	2.68851832
76	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.66095689
77	GPI anchor biosynthetic process (GO:0006506)	2.66010655
78	meiotic chromosome segregation (GO:0045132)	2.65994351
79	aspartate family amino acid catabolic process (GO:0009068)	2.65775908
80	indole-containing compound catabolic process (GO:0042436)	2.65082420
81	indolalkylamine catabolic process (GO:0046218)	2.65082420
82	tryptophan catabolic process (GO:0006569)	2.65082420
83	gamma-aminobutyric acid transport (GO:0015812)	2.62953319
84	positive regulation of mitochondrial fission (GO:0090141)	2.62662375
85	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.61582143
86	NADH dehydrogenase complex assembly (GO:0010257)	2.61582143
87	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.61582143
88	photoreceptor cell development (GO:0042461)	2.61136188
89	methionine metabolic process (GO:0006555)	2.60418903
90	establishment of protein localization to Golgi (GO:0072600)	2.58871910
91	metallo-sulfur cluster assembly (GO:0031163)	2.58725077
92	iron-sulfur cluster assembly (GO:0016226)	2.58725077
93	mismatch repair (GO:0006298)	2.57898663
94	rhodopsin mediated signaling pathway (GO:0016056)	2.55808556
95	positive regulation of action potential (GO:0045760)	2.54035155
96	sulfation (GO:0051923)	2.53985620
97	protein deneddylation (GO:0000338)	2.53825071
98	centriole replication (GO:0007099)	2.53129003
99	protein polyglutamylation (GO:0018095)	2.50818911
100	histone mRNA catabolic process (GO:0071044)	2.50378251

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.79902456
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.66821686
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.98600946
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.62121259
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.60749779
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.56623115
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46294300
8	VDR_22108803_ChIP-Seq_LS180_Human	2.42860858
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.41485668
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38209525
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37146075
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15495136
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.09004542
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.07338308
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04951924
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03721678
17	EWS_26573619_Chip-Seq_HEK293_Human	2.03503042
18	FUS_26573619_Chip-Seq_HEK293_Human	2.01833780
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.99472685
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.95614767
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.92672469
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.91323600
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.90840671
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.86591258
25	P300_19829295_ChIP-Seq_ESCs_Human	1.83910740
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76217021
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71733561
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.69676846
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69676846
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69133472
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.68128381
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65888286
33	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.65870481
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.61880889
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58954969
36	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.57865782
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55861243
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.55363966
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54730270
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53448049
41	STAT3_23295773_ChIP-Seq_U87_Human	1.50756104
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.48236543
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47149848
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.44320112
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39020000
46	EZH2_22144423_ChIP-Seq_EOC_Human	1.36812929
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35920872
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35876903
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35876903
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34690657
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.34645192
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33862309
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32753037
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32446805
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32446805
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31360509
57	NCOR_22424771_ChIP-Seq_293T_Human	1.30906902
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.27500909
59	TCF4_23295773_ChIP-Seq_U87_Human	1.25667026
60	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24679832
61	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22112603
62	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.21506337
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20539814
64	AR_25329375_ChIP-Seq_VCAP_Human	1.20008394
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17625376
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16578441
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16348123
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.13150749
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12737533
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12690839
71	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.12180871
72	AR_20517297_ChIP-Seq_VCAP_Human	1.12177280
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.12170739
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11777363
75	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.08802072
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08714250
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07042580
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05895234
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05157682
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05141587
81	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04936125
82	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.04870634
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.04640371
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04506191
85	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.03848495
86	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01574240
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01009893
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00595844
89	* SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99659498
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99623383
91	GATA3_26560356_Chip-Seq_TH1_Human	0.99159864
92	BCAT_22108803_ChIP-Seq_LS180_Human	0.97373912
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96976531
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96142593
95	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.95107843
96	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95052888
97	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95052888
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93972536
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93695485
100	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.93360987

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.02400216
2	MP0002653_abnormal_ependyma_morphology	2.94328232
3	MP0001984_abnormal_olfaction	2.85282599
4	MP0002102_abnormal_ear_morphology	2.71894673
5	MP0004147_increased_porphyrin_level	2.59921220
6	MP0001529_abnormal_vocalization	2.53045916
7	MP0002132_abnormal_respiratory_system	2.52460128
8	MP0005410_abnormal_fertilization	2.43308761
9	MP0005551_abnormal_eye_electrophysiolog	2.27708759
10	MP0003718_maternal_effect	2.25783607
11	MP0006276_abnormal_autonomic_nervous	2.25288175
12	MP0003136_yellow_coat_color	2.24807692
13	MP0008058_abnormal_DNA_repair	2.17658352
14	MP0005253_abnormal_eye_physiology	2.02546971
15	MP0006072_abnormal_retinal_apoptosis	1.93210292
16	MP0003890_abnormal_embryonic-extraembry	1.92619053
17	MP0005394_taste/olfaction_phenotype	1.88475858
18	MP0005499_abnormal_olfactory_system	1.88475858
19	MP0003646_muscle_fatigue	1.87144152
20	MP0009697_abnormal_copulation	1.86097193
21	MP0000372_irregular_coat_pigmentation	1.82853055
22	MP0006054_spinal_hemorrhage	1.79630142
23	MP0003693_abnormal_embryo_hatching	1.76690816
24	MP0002736_abnormal_nociception_after	1.71828125
25	MP0001968_abnormal_touch/_nociception	1.69027126
26	MP0008789_abnormal_olfactory_epithelium	1.68493021
27	MP0008872_abnormal_physiological_respon	1.68019487
28	MP0001929_abnormal_gametogenesis	1.65632011
29	MP0005646_abnormal_pituitary_gland	1.64918958
30	MP0001986_abnormal_taste_sensitivity	1.63883930
31	MP0005075_abnormal_melanosome_morpholog	1.58850041
32	MP0003195_calcinosis	1.57360764
33	MP0010094_abnormal_chromosome_stability	1.54520768
34	MP0002837_dystrophic_cardiac_calcinosis	1.54033885
35	MP0006292_abnormal_olfactory_placode	1.53444451
36	MP0003698_abnormal_male_reproductive	1.51143046
37	MP0001293_anophthalmia	1.50643669
38	MP0006035_abnormal_mitochondrial_morpho	1.45953042
39	MP0005171_absent_coat_pigmentation	1.45759903
40	MP0001764_abnormal_homeostasis	1.45629110
41	MP0009046_muscle_twitch	1.45289706
42	MP0002751_abnormal_autonomic_nervous	1.40081445
43	MP0000427_abnormal_hair_cycle	1.38113450
44	MP0002638_abnormal_pupillary_reflex	1.36241204
45	MP0005377_hearing/vestibular/ear_phenot	1.32095441
46	MP0003878_abnormal_ear_physiology	1.32095441
47	MP0005083_abnormal_biliary_tract	1.31121136
48	MP0001486_abnormal_startle_reflex	1.27935400
49	MP0000569_abnormal_digit_pigmentation	1.25350151
50	MP0002210_abnormal_sex_determination	1.24668760
51	MP0002735_abnormal_chemical_nociception	1.23932515
52	MP0003880_abnormal_central_pattern	1.23625108
53	MP0002160_abnormal_reproductive_system	1.22212649
54	MP0001485_abnormal_pinna_reflex	1.17649222
55	MP0003787_abnormal_imprinting	1.17194156
56	MP0010386_abnormal_urinary_bladder	1.16497081
57	MP0008995_early_reproductive_senescence	1.16324511
58	MP0000653_abnormal_sex_gland	1.10391246
59	MP0002229_neurodegeneration	1.06036888
60	MP0006036_abnormal_mitochondrial_physio	1.02541871
61	MP0005084_abnormal_gallbladder_morpholo	1.01522717
62	MP0005391_vision/eye_phenotype	1.00033693
63	MP0008932_abnormal_embryonic_tissue	0.98475956
64	MP0001145_abnormal_male_reproductive	0.97569454
65	MP0009745_abnormal_behavioral_response	0.95934335
66	MP0004215_abnormal_myocardial_fiber	0.95602375
67	MP0001119_abnormal_female_reproductive	0.94425157
68	MP0002928_abnormal_bile_duct	0.94369140
69	MP0005395_other_phenotype	0.92971929
70	MP0004142_abnormal_muscle_tone	0.91946464
71	MP0004264_abnormal_extraembryonic_tissu	0.90852422
72	MP0005645_abnormal_hypothalamus_physiol	0.89705817
73	MP0002938_white_spotting	0.89681617
74	MP0001324_abnormal_eye_pigmentation	0.89258465
75	MP0001970_abnormal_pain_threshold	0.87047483
76	MP0005174_abnormal_tail_pigmentation	0.86740667
77	MP0003656_abnormal_erythrocyte_physiolo	0.86065646
78	MP0002822_catalepsy	0.82893493
79	MP0005085_abnormal_gallbladder_physiolo	0.81538165
80	MP0002161_abnormal_fertility/fecundity	0.81113251
81	MP0005389_reproductive_system_phenotype	0.80514863
82	MP0002272_abnormal_nervous_system	0.80482520
83	MP0002733_abnormal_thermal_nociception	0.80253456
84	MP0002090_abnormal_vision	0.78974064
85	MP0003879_abnormal_hair_cell	0.78041285
86	MP0001501_abnormal_sleep_pattern	0.78030590
87	MP0000383_abnormal_hair_follicle	0.77632816
88	MP0004145_abnormal_muscle_electrophysio	0.77321741
89	MP0005266_abnormal_metabolism	0.76550108
90	MP0000647_abnormal_sebaceous_gland	0.75377637
91	MP0002067_abnormal_sensory_capabilities	0.75129997
92	MP0002572_abnormal_emotion/affect_behav	0.72794354
93	MP0005195_abnormal_posterior_eye	0.72388844
94	MP0008875_abnormal_xenobiotic_pharmacok	0.72258143
95	MP0003077_abnormal_cell_cycle	0.72078919
96	MP0005310_abnormal_salivary_gland	0.71299675
97	MP0008057_abnormal_DNA_replication	0.71037913
98	MP0004484_altered_response_of	0.70404690
99	MP0002752_abnormal_somatic_nervous	0.68923863
100	MP0003121_genomic_imprinting	0.68237464

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.02888280
2	Medial flaring of the eyebrow (HP:0010747)	3.65780436
3	Pancreatic fibrosis (HP:0100732)	3.53768751
4	True hermaphroditism (HP:0010459)	3.53461983
5	Congenital primary aphakia (HP:0007707)	3.38885793
6	Attenuation of retinal blood vessels (HP:0007843)	3.38311271
7	Gait imbalance (HP:0002141)	3.26898634
8	Bony spicule pigmentary retinopathy (HP:0007737)	3.16112574
9	Nephrogenic diabetes insipidus (HP:0009806)	3.11363185
10	Nephronophthisis (HP:0000090)	3.03004169
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.02191143
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.86166904
13	Hyperglycinuria (HP:0003108)	2.85045176
14	Congenital stationary night blindness (HP:0007642)	2.82033069
15	Hyperglycinemia (HP:0002154)	2.81932794
16	Abnormality of midbrain morphology (HP:0002418)	2.79057061
17	Molar tooth sign on MRI (HP:0002419)	2.79057061
18	Chronic hepatic failure (HP:0100626)	2.78326418
19	Colon cancer (HP:0003003)	2.78114145
20	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.76509916
21	Tubulointerstitial nephritis (HP:0001970)	2.70754002
22	Genital tract atresia (HP:0001827)	2.56993936
23	Abnormality of alanine metabolism (HP:0010916)	2.56704362
24	Hyperalaninemia (HP:0003348)	2.56704362
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.56704362
26	Poor coordination (HP:0002370)	2.52954531
27	Abnormality of the renal medulla (HP:0100957)	2.52730287
28	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.51638384
29	Type II lissencephaly (HP:0007260)	2.50398874
30	Abnormality of serine family amino acid metabolism (HP:0010894)	2.47829552
31	Abnormality of glycine metabolism (HP:0010895)	2.47829552
32	Vaginal atresia (HP:0000148)	2.46779907
33	Abnormality of the renal cortex (HP:0011035)	2.46065888
34	Retinal dysplasia (HP:0007973)	2.45854244
35	Abolished electroretinogram (ERG) (HP:0000550)	2.45623665
36	Abnormal ciliary motility (HP:0012262)	2.42688617
37	Decreased central vision (HP:0007663)	2.40197483
38	Cerebellar dysplasia (HP:0007033)	2.39601005
39	3-Methylglutaconic aciduria (HP:0003535)	2.36906226
40	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36638645
41	Absent/shortened dynein arms (HP:0200106)	2.36638645
42	Retinitis pigmentosa (HP:0000510)	2.36618238
43	Gaze-evoked nystagmus (HP:0000640)	2.34964450
44	Type I transferrin isoform profile (HP:0003642)	2.30111947
45	Thyroid-stimulating hormone excess (HP:0002925)	2.29329542
46	Abnormal protein glycosylation (HP:0012346)	2.25292136
47	Abnormal glycosylation (HP:0012345)	2.25292136
48	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.25292136
49	Abnormal protein N-linked glycosylation (HP:0012347)	2.25292136
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.24355973
51	Severe visual impairment (HP:0001141)	2.20769832
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.20477743
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.20477743
54	Cystic liver disease (HP:0006706)	2.18581844
55	Hepatocellular necrosis (HP:0001404)	2.15274939
56	Abnormality of serum amino acid levels (HP:0003112)	2.14858175
57	Central scotoma (HP:0000603)	2.12386878
58	Abnormality of the labia minora (HP:0012880)	2.12359983
59	Ependymoma (HP:0002888)	2.10754473
60	Short tibia (HP:0005736)	2.09222084
61	Increased serum lactate (HP:0002151)	2.08398349
62	Hepatic necrosis (HP:0002605)	2.05875910
63	Increased CSF lactate (HP:0002490)	2.04752164
64	Postaxial foot polydactyly (HP:0001830)	2.04002269
65	Congenital hepatic fibrosis (HP:0002612)	2.02177050
66	Abnormal respiratory motile cilium physiology (HP:0012261)	2.01747937
67	Stomach cancer (HP:0012126)	1.99984662
68	Abnormality of macular pigmentation (HP:0008002)	1.97644586
69	Acute encephalopathy (HP:0006846)	1.94859229
70	Postaxial hand polydactyly (HP:0001162)	1.94017980
71	Congenital sensorineural hearing impairment (HP:0008527)	1.93631750
72	Renal cortical cysts (HP:0000803)	1.91736848
73	Methylmalonic aciduria (HP:0012120)	1.91649419
74	Abnormality of the ileum (HP:0001549)	1.91397515
75	Tubular atrophy (HP:0000092)	1.90298405
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90010436
77	Broad foot (HP:0001769)	1.89979181
78	Progressive cerebellar ataxia (HP:0002073)	1.86728477
79	Mitochondrial inheritance (HP:0001427)	1.85951256
80	Supernumerary spleens (HP:0009799)	1.85192431
81	Sclerocornea (HP:0000647)	1.85171481
82	Meckel diverticulum (HP:0002245)	1.84150998
83	Astigmatism (HP:0000483)	1.82483763
84	Choroideremia (HP:0001139)	1.82387089
85	Genetic anticipation (HP:0003743)	1.81621060
86	Stomatitis (HP:0010280)	1.81184617
87	Anencephaly (HP:0002323)	1.80457344
88	Sloping forehead (HP:0000340)	1.78741808
89	Dialeptic seizures (HP:0011146)	1.78173299
90	Polyphagia (HP:0002591)	1.76970978
91	Male pseudohermaphroditism (HP:0000037)	1.75703175
92	Progressive inability to walk (HP:0002505)	1.75258331
93	Opisthotonus (HP:0002179)	1.74613788
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.73137148
95	IgG deficiency (HP:0004315)	1.72671606
96	Inability to walk (HP:0002540)	1.70738907
97	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.70164363
98	Pendular nystagmus (HP:0012043)	1.70033455
99	Lipid accumulation in hepatocytes (HP:0006561)	1.69866186
100	Preaxial hand polydactyly (HP:0001177)	1.69474264

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK12	4.98715141
2	FRK	4.68141370
3	TAOK3	4.02862421
4	MAP4K2	3.86243446
5	BRD4	2.82675318
6	TRIM28	2.77064748
7	ZAK	2.68732618
8	TESK2	2.33083097
9	BMPR1B	2.27011196
10	ACVR1B	2.18183001
11	STK38L	2.13510911
12	WNK3	2.11985381
13	ADRBK2	1.91186799
14	LATS1	1.88709987
15	CDK19	1.79316330
16	BCKDK	1.77930187
17	CSNK1A1L	1.76807760
18	PBK	1.59739927
19	NUAK1	1.54828139
20	BCR	1.42339917
21	MAP2K7	1.41761504
22	MST4	1.41092987
23	CSNK1G3	1.34152248
24	SRPK1	1.31829964
25	MUSK	1.30908321
26	EPHA4	1.29847187
27	NLK	1.25734140
28	CSNK1G1	1.25190270
29	MAP3K4	1.24993138
30	PIK3CG	1.24636946
31	CSNK1G2	1.24459615
32	PINK1	1.24115796
33	CAMKK2	1.22596113
34	TLK1	1.12503348
35	GRK1	1.10433505
36	PLK2	0.99385123
37	PTK2B	0.91608437
38	VRK1	0.87584810
39	MAPK13	0.81333392
40	DYRK3	0.80636485
41	EIF2AK3	0.79963017
42	STK16	0.79952235
43	PLK4	0.75055514
44	OXSR1	0.74168110
45	INSRR	0.73184900
46	TNIK	0.72249918
47	VRK2	0.71157094
48	CDK9	0.70369171
49	TEC	0.69693800
50	MATK	0.69103145
51	STK3	0.68354710
52	GRK5	0.67219182
53	EPHA3	0.65966301
54	FER	0.65209717
55	MKNK2	0.64228414
56	RPS6KA4	0.63872478
57	TXK	0.63555226
58	EIF2AK1	0.61592274
59	DYRK1A	0.61405199
60	ADRBK1	0.61337051
61	DYRK2	0.60949189
62	PLK3	0.60075518
63	BRSK2	0.59853896
64	TSSK6	0.59229747
65	RPS6KA5	0.57408249
66	MARK3	0.57303247
67	ERBB3	0.53790505
68	PLK1	0.52831992
69	MKNK1	0.51849680
70	STK38	0.51571015
71	ATR	0.49490938
72	NEK2	0.47837468
73	FLT3	0.47030156
74	PRKCE	0.43375867
75	LATS2	0.41073265
76	NME1	0.39187153
77	IRAK1	0.38163755
78	CDC7	0.37840245
79	KDR	0.37203882
80	NEK6	0.34771362
81	MAP3K5	0.34613111
82	TNK2	0.34139988
83	CDK3	0.33803637
84	AURKA	0.29913822
85	ATM	0.29663766
86	STK39	0.29212249
87	CHEK2	0.28576008
88	WNK4	0.28538721
89	CDK7	0.27063012
90	PRKACB	0.26941416
91	CAMK2A	0.26760741
92	PIM2	0.26471179
93	IKBKB	0.25671034
94	TGFBR1	0.24944221
95	TTK	0.24793610
96	MELK	0.24452747
97	PIM1	0.24142557
98	CSNK1A1	0.23099797
99	PKN1	0.20537920
100	CSNK1D	0.20184295

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.56327499
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.82252908
3	RNA polymerase_Homo sapiens_hsa03020	2.79307549
4	Basal transcription factors_Homo sapiens_hsa03022	2.60878326
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.45478648
6	Homologous recombination_Homo sapiens_hsa03440	2.25756810
7	Propanoate metabolism_Homo sapiens_hsa00640	2.19650135
8	Butanoate metabolism_Homo sapiens_hsa00650	2.19315434
9	Proteasome_Homo sapiens_hsa03050	2.05159417
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.05072703
11	Mismatch repair_Homo sapiens_hsa03430	1.98073449
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83483093
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.80220434
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.68971830
15	Olfactory transduction_Homo sapiens_hsa04740	1.67443828
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66932615
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.57135097
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55027201
19	RNA degradation_Homo sapiens_hsa03018	1.53200749
20	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.52051814
21	Purine metabolism_Homo sapiens_hsa00230	1.51063507
22	Protein export_Homo sapiens_hsa03060	1.50919131
23	Nicotine addiction_Homo sapiens_hsa05033	1.50389104
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.45791693
25	Taste transduction_Homo sapiens_hsa04742	1.43193643
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41780491
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.41313341
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.37375462
29	Regulation of autophagy_Homo sapiens_hsa04140	1.35429300
30	Base excision repair_Homo sapiens_hsa03410	1.34526950
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.32400030
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31943490
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.29843859
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.29659487
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.29605701
36	RNA transport_Homo sapiens_hsa03013	1.28948057
37	Parkinsons disease_Homo sapiens_hsa05012	1.27438709
38	GABAergic synapse_Homo sapiens_hsa04727	1.23033705
39	Huntingtons disease_Homo sapiens_hsa05016	1.22219448
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.21874422
41	One carbon pool by folate_Homo sapiens_hsa00670	1.20955743
42	Peroxisome_Homo sapiens_hsa04146	1.19956670
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15782759
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15708865
45	Glutathione metabolism_Homo sapiens_hsa00480	1.11787450
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09864450
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07580478
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06107920
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04758306
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03175175
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.00417486
52	Fatty acid elongation_Homo sapiens_hsa00062	0.97163226
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94451448
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.93910633
55	ABC transporters_Homo sapiens_hsa02010	0.93253026
56	Morphine addiction_Homo sapiens_hsa05032	0.92672228
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.91065596
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90478815
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.89259945
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89088719
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88841937
62	DNA replication_Homo sapiens_hsa03030	0.87063970
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86247161
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85393540
65	Metabolic pathways_Homo sapiens_hsa01100	0.83412878
66	Oocyte meiosis_Homo sapiens_hsa04114	0.81141217
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81084410
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80701846
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.78653415
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77741628
71	Cell cycle_Homo sapiens_hsa04110	0.77105274
72	Sulfur relay system_Homo sapiens_hsa04122	0.76637522
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75519412
74	Serotonergic synapse_Homo sapiens_hsa04726	0.74584187
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.73761340
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72072857
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.71794019
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.71617007
79	Circadian rhythm_Homo sapiens_hsa04710	0.65085328
80	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63948515
81	Spliceosome_Homo sapiens_hsa03040	0.63918177
82	Retinol metabolism_Homo sapiens_hsa00830	0.63628928
83	Alcoholism_Homo sapiens_hsa05034	0.61424858
84	Circadian entrainment_Homo sapiens_hsa04713	0.61362784
85	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.61020932
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.54530325
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.51797383
88	Alzheimers disease_Homo sapiens_hsa05010	0.51739460
89	Lysine degradation_Homo sapiens_hsa00310	0.50469311
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49503290
91	Salivary secretion_Homo sapiens_hsa04970	0.49471210
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47106473
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46535566
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44787381
95	mRNA surveillance pathway_Homo sapiens_hsa03015	0.44534150
96	Sulfur metabolism_Homo sapiens_hsa00920	0.43015124
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.40842604
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40765871
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.37738899
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35426324

C2ORF61

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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