C2ORF66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of integrin-mediated signaling pathway (GO:2001044)5.18353515
2thrombin receptor signaling pathway (GO:0070493)5.08009981
3protein neddylation (GO:0045116)5.04704020
4negative regulation of protein localization to cell surface (GO:2000009)4.38696674
5fucose catabolic process (GO:0019317)4.21997491
6L-fucose metabolic process (GO:0042354)4.21997491
7L-fucose catabolic process (GO:0042355)4.21997491
8pyrimidine nucleobase catabolic process (GO:0006208)4.10770110
9mitochondrial calcium ion transport (GO:0006851)4.06815821
10histone H3-K36 demethylation (GO:0070544)4.01778287
11negative regulation of thymocyte apoptotic process (GO:0070244)3.87790487
12cilium or flagellum-dependent cell motility (GO:0001539)3.84574145
13negative regulation of heart rate (GO:0010459)3.73561624
14regulation of immunoglobulin secretion (GO:0051023)3.73096438
15fatty acid elongation (GO:0030497)3.70992120
16extracellular fibril organization (GO:0043206)3.68069322
17positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.66829999
18long-chain fatty acid biosynthetic process (GO:0042759)3.63337041
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.57583955
20G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.55244947
21adenosine receptor signaling pathway (GO:0001973)3.55175754
22cullin deneddylation (GO:0010388)3.52855535
23neutrophil activation involved in immune response (GO:0002283)3.48652394
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47255031
25negative regulation of response to food (GO:0032096)3.46637172
26negative regulation of appetite (GO:0032099)3.46637172
27behavioral response to cocaine (GO:0048148)3.43646975
28protein localization to cilium (GO:0061512)3.41979580
29negative regulation of platelet activation (GO:0010544)3.34256038
30negative regulation of neurotransmitter transport (GO:0051589)3.27840459
31cilium movement (GO:0003341)3.21751708
32regulation of meiosis I (GO:0060631)3.21057727
33sleep (GO:0030431)3.20028816
34sequestering of actin monomers (GO:0042989)3.16215654
35angiogenesis involved in wound healing (GO:0060055)3.12919389
36microtubule depolymerization (GO:0007019)3.11388804
37fibril organization (GO:0097435)3.06386533
38purinergic nucleotide receptor signaling pathway (GO:0035590)3.05514856
39protein deneddylation (GO:0000338)3.05446108
40regulation of platelet activation (GO:0010543)3.04113784
41epithelial cilium movement (GO:0003351)3.00924505
42nucleobase catabolic process (GO:0046113)2.98711548
43mesodermal cell differentiation (GO:0048333)2.93647776
44negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.93508735
45left/right pattern formation (GO:0060972)2.91247373
46lung lobe morphogenesis (GO:0060463)2.90623018
47regulation of penile erection (GO:0060405)2.89900951
48negative regulation of norepinephrine secretion (GO:0010700)2.89242214
49activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.88919444
50axonemal dynein complex assembly (GO:0070286)2.88295730
51regulation of cytokine production involved in inflammatory response (GO:1900015)2.88066394
52negative regulation of nitric-oxide synthase activity (GO:0051001)2.87796042
53regulation of sensory perception of pain (GO:0051930)2.85365658
54regulation of sensory perception (GO:0051931)2.85365658
55response to gravity (GO:0009629)2.85040762
56positive regulation of endothelial cell differentiation (GO:0045603)2.84495359
57regulation of memory T cell differentiation (GO:0043380)2.81966783
58regulation of platelet aggregation (GO:0090330)2.80528097
59positive regulation of p38MAPK cascade (GO:1900745)2.80329885
60negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.79321772
61regulation of T-helper 1 cell differentiation (GO:0045625)2.78756558
62negative regulation of homotypic cell-cell adhesion (GO:0034111)2.78034565
63response to pheromone (GO:0019236)2.72866055
64mechanosensory behavior (GO:0007638)2.70240757
65endocytic recycling (GO:0032456)2.70026228
66negative chemotaxis (GO:0050919)2.68947769
67fusion of sperm to egg plasma membrane (GO:0007342)2.67299562
68regulation of Golgi to plasma membrane protein transport (GO:0042996)2.67212853
69regulation of norepinephrine secretion (GO:0014061)2.67182656
70regulation of cilium movement (GO:0003352)2.66956998
71autophagic vacuole fusion (GO:0000046)2.66786886
72regulation of integrin activation (GO:0033623)2.64756686
73low-density lipoprotein particle remodeling (GO:0034374)2.62596229
74platelet aggregation (GO:0070527)2.62179389
75regulation of axon guidance (GO:1902667)2.59435580
76negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.57537576
77negative regulation of calcium ion transmembrane transport (GO:1903170)2.57537576
78skeletal muscle tissue regeneration (GO:0043403)2.57323312
79negative regulation of calcium ion transport into cytosol (GO:0010523)2.55928684
80JAK-STAT cascade (GO:0007259)2.55786373
81fibroblast migration (GO:0010761)2.53729854
82protein localization to synapse (GO:0035418)2.52433083
83regulation of pigment cell differentiation (GO:0050932)2.52269773
84mitochondrial calcium ion homeostasis (GO:0051560)2.52198919
85negative regulation of heart contraction (GO:0045822)2.51398530
86regulation of phospholipid biosynthetic process (GO:0071071)2.51347915
87chemosensory behavior (GO:0007635)2.50149110
88negative regulation of execution phase of apoptosis (GO:1900118)2.49799632
89metanephric mesenchyme development (GO:0072075)2.48744496
90positive regulation of Rho protein signal transduction (GO:0035025)2.45887508
91G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.44949189
92positive regulation of blood coagulation (GO:0030194)2.44919098
93positive regulation of hemostasis (GO:1900048)2.44919098
94purinergic receptor signaling pathway (GO:0035587)2.44416873
95regulation of appetite (GO:0032098)2.44000005
96alanine transport (GO:0032328)2.43957931
97platelet degranulation (GO:0002576)2.41638076
98negative regulation of T-helper cell differentiation (GO:0045623)2.41362795
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.41362795
100blood coagulation, intrinsic pathway (GO:0007597)2.39505543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06969105
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.58449034
3GBX2_23144817_ChIP-Seq_PC3_Human2.98349632
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81259926
5EZH2_22144423_ChIP-Seq_EOC_Human2.71592597
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.68684142
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60501374
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50717041
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.49501655
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.37432413
11VDR_22108803_ChIP-Seq_LS180_Human2.33708328
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29932951
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17917919
14PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.13481730
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96809266
16FUS_26573619_Chip-Seq_HEK293_Human1.90751300
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87833940
18SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84943275
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84017695
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82439459
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81827141
22BCAT_22108803_ChIP-Seq_LS180_Human1.70771061
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70535007
24TAF15_26573619_Chip-Seq_HEK293_Human1.66206228
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64069352
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63078351
27SMAD4_21799915_ChIP-Seq_A2780_Human1.61966769
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.59086944
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.57994146
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51486546
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51486546
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50481344
33EWS_26573619_Chip-Seq_HEK293_Human1.48032014
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47627067
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46367711
36IGF1R_20145208_ChIP-Seq_DFB_Human1.44236656
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43106673
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41258507
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41024660
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38711380
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38086096
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37496728
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37493557
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.36135203
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.35700521
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.35518047
47CJUN_26792858_Chip-Seq_BT549_Human1.33950058
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33191009
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29998617
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29553500
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29130708
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.27504117
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26298149
54P53_22387025_ChIP-Seq_ESCs_Mouse1.26155127
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25587023
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.25509034
57STAT3_23295773_ChIP-Seq_U87_Human1.22563690
58P300_19829295_ChIP-Seq_ESCs_Human1.22309689
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.22285954
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.21091696
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20656485
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16327138
63ZNF274_21170338_ChIP-Seq_K562_Hela1.15082663
64ER_23166858_ChIP-Seq_MCF-7_Human1.14301451
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12829748
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11967106
67TP53_18474530_ChIP-ChIP_U2OS_Human1.11653052
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11553916
69CDX2_22108803_ChIP-Seq_LS180_Human1.09836349
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.09741237
71* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09292876
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09059836
73RUNX_20019798_ChIP-Seq_JUKART_Human1.07958271
74AR_25329375_ChIP-Seq_VCAP_Human1.07828796
75P300_18555785_Chip-Seq_ESCs_Mouse1.06023919
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.03952528
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03567611
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01781601
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01552475
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01552475
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01051846
82CMYC_18555785_Chip-Seq_ESCs_Mouse0.99949775
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99493885
84TCF4_23295773_ChIP-Seq_U87_Human0.99303450
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98563364
86TCF4_22108803_ChIP-Seq_LS180_Human0.97759771
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97711985
88WT1_19549856_ChIP-ChIP_CCG9911_Human0.96448639
89SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96255741
90TP63_23658742_ChIP-Seq_EP156T_Human0.94433898
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94047743
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.93428642
93RUNX2_22187159_ChIP-Seq_PCA_Human0.92947456
94TBL1_22424771_ChIP-Seq_293T_Human0.92733488
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92021417
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.91874351
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91710992
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.91673068
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91222719
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.90181862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after6.18977872
2MP0005464_abnormal_platelet_physiology4.14699721
3MP0003136_yellow_coat_color4.13052241
4MP0001968_abnormal_touch/_nociception3.86504706
5MP0002735_abnormal_chemical_nociception3.62347591
6MP0008004_abnormal_stomach_pH2.83411545
7MP0010352_gastrointestinal_tract_polyps2.71754151
8MP0003283_abnormal_digestive_organ2.63797918
9MP0003303_peritoneal_inflammation2.35063024
10MP0001849_ear_inflammation2.14682187
11MP0008775_abnormal_heart_ventricle2.04058957
12MP0005171_absent_coat_pigmentation1.98481135
13MP0005187_abnormal_penis_morphology1.97146448
14MP0004510_myositis1.97042182
15MP0002733_abnormal_thermal_nociception1.92311066
16MP0009785_altered_susceptibility_to1.89683755
17MP0005623_abnormal_meninges_morphology1.81445402
18MP0002102_abnormal_ear_morphology1.74128418
19MP0010368_abnormal_lymphatic_system1.65970977
20MP0000566_synostosis1.65837235
21MP0004084_abnormal_cardiac_muscle1.59615619
22MP0001879_abnormal_lymphatic_vessel1.55747190
23MP0001970_abnormal_pain_threshold1.55743706
24MP0000372_irregular_coat_pigmentation1.49050569
25MP0003724_increased_susceptibility_to1.48130222
26MP0005409_darkened_coat_color1.47128234
27MP0008872_abnormal_physiological_respon1.46792091
28MP0003950_abnormal_plasma_membrane1.43562988
29MP0005367_renal/urinary_system_phenotyp1.41583334
30MP0000516_abnormal_urinary_system1.41583334
31MP0000579_abnormal_nail_morphology1.39510759
32MP0001958_emphysema1.38567432
33MP0002148_abnormal_hypersensitivity_rea1.26331620
34MP0002734_abnormal_mechanical_nocicepti1.25777510
35MP0005671_abnormal_response_to1.25293582
36MP0000534_abnormal_ureter_morphology1.24356791
37MP0000465_gastrointestinal_hemorrhage1.23980551
38MP0000230_abnormal_systemic_arterial1.22477900
39MP0001299_abnormal_eye_distance/1.21492160
40MP0002234_abnormal_pharynx_morphology1.21056188
41MP0002095_abnormal_skin_pigmentation1.16716673
42MP0001835_abnormal_antigen_presentation1.13952383
43MP0005164_abnormal_response_to1.13326651
44MP0006138_congestive_heart_failure1.12534897
45MP0001501_abnormal_sleep_pattern1.10000239
46MP0004142_abnormal_muscle_tone1.06924381
47MP0005248_abnormal_Harderian_gland1.06526131
48MP0004883_abnormal_blood_vessel1.06263387
49MP0000427_abnormal_hair_cycle1.05159618
50MP0010155_abnormal_intestine_physiology1.03070789
51MP0004859_abnormal_synaptic_plasticity1.02772499
52MP0006054_spinal_hemorrhage1.01786881
53MP0009780_abnormal_chondrocyte_physiolo1.00794281
54MP0004036_abnormal_muscle_relaxation0.97129832
55MP0005084_abnormal_gallbladder_morpholo0.95569760
56MP0009250_abnormal_appendicular_skeleto0.95177076
57MP0008875_abnormal_xenobiotic_pharmacok0.94998950
58MP0008569_lethality_at_weaning0.93821606
59MP0002638_abnormal_pupillary_reflex0.92235919
60MP0003566_abnormal_cell_adhesion0.91914779
61MP0003091_abnormal_cell_migration0.89979004
62MP0003436_decreased_susceptibility_to0.89653922
63MP0004381_abnormal_hair_follicle0.88963242
64MP0002295_abnormal_pulmonary_circulatio0.84578650
65MP0001663_abnormal_digestive_system0.84432408
66MP0005535_abnormal_body_temperature0.83535436
67MP0000647_abnormal_sebaceous_gland0.83135384
68MP0001544_abnormal_cardiovascular_syste0.82104364
69MP0005385_cardiovascular_system_phenoty0.82104364
70MP0005167_abnormal_blood-brain_barrier0.81774566
71MP0002177_abnormal_outer_ear0.81649235
72MP0001533_abnormal_skeleton_physiology0.81342376
73MP0008438_abnormal_cutaneous_collagen0.80357881
74MP0001853_heart_inflammation0.79556578
75MP0005275_abnormal_skin_tensile0.79107242
76MP0005410_abnormal_fertilization0.79064504
77MP0003011_delayed_dark_adaptation0.78655299
78MP0002282_abnormal_trachea_morphology0.78629942
79MP0000343_altered_response_to0.78171623
80MP0005000_abnormal_immune_tolerance0.77428371
81MP0004885_abnormal_endolymph0.76758378
82MP0000778_abnormal_nervous_system0.74009767
83MP0005023_abnormal_wound_healing0.73753228
84MP0000015_abnormal_ear_pigmentation0.73366914
85MP0005388_respiratory_system_phenotype0.72446096
86MP0002133_abnormal_respiratory_system0.72446096
87MP0001542_abnormal_bone_strength0.72368333
88MP0004215_abnormal_myocardial_fiber0.71707975
89MP0008789_abnormal_olfactory_epithelium0.70828614
90MP0003045_fibrosis0.66815063
91MP0002653_abnormal_ependyma_morphology0.66366766
92MP0006276_abnormal_autonomic_nervous0.65307920
93MP0000249_abnormal_blood_vessel0.64497301
94MP0002233_abnormal_nose_morphology0.64150564
95MP0002128_abnormal_blood_circulation0.63960999
96MP0003880_abnormal_central_pattern0.63922446
97MP0002557_abnormal_social/conspecific_i0.62528648
98MP0005390_skeleton_phenotype0.62441976
99MP0008961_abnormal_basal_metabolism0.62096186
100MP0004484_altered_response_of0.61968385

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)6.21028459
2Retrobulbar optic neuritis (HP:0100654)6.21028459
3Orchitis (HP:0100796)5.46358827
4Increased mean platelet volume (HP:0011877)5.33748727
5Prolonged bleeding time (HP:0003010)5.23924504
6Menorrhagia (HP:0000132)5.11318756
7Abnormal platelet volume (HP:0011876)4.78991966
8Keratoconjunctivitis sicca (HP:0001097)4.70511283
9Myositis (HP:0100614)4.51951532
10Tetraparesis (HP:0002273)4.40575011
11Keratoconjunctivitis (HP:0001096)4.25336094
12Petechiae (HP:0000967)4.09363365
13Epistaxis (HP:0000421)4.03054786
14Abnormal ciliary motility (HP:0012262)3.99882226
15Hyperlipoproteinemia (HP:0010980)3.82006947
16Abnormal respiratory motile cilium morphology (HP:0005938)3.76917912
17Abnormal respiratory epithelium morphology (HP:0012253)3.76917912
18Purpura (HP:0000979)3.75604221
19Joint swelling (HP:0001386)3.51231933
20Gingival bleeding (HP:0000225)3.36232096
21Impaired platelet aggregation (HP:0003540)3.16694729
22Abnormal platelet function (HP:0011869)3.16694729
23Absent/shortened dynein arms (HP:0200106)3.16394527
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.16394527
25Portal hypertension (HP:0001409)3.12649472
26Arterial thrombosis (HP:0004420)3.11650774
27Dyschromatopsia (HP:0007641)3.02904938
28Abnormal respiratory motile cilium physiology (HP:0012261)2.98790099
29Tubulointerstitial fibrosis (HP:0005576)2.91747476
30Tubulointerstitial abnormality (HP:0001969)2.88013788
31Abnormality of the hepatic vasculature (HP:0006707)2.77153610
32Upper limb muscle weakness (HP:0003484)2.76682902
33Papillary thyroid carcinoma (HP:0002895)2.76375670
34Fibular aplasia (HP:0002990)2.74864809
35Abnormal auditory evoked potentials (HP:0006958)2.73298526
36Long clavicles (HP:0000890)2.66001107
37Abnormality of the ischium (HP:0003174)2.56452725
38Hypoplastic ischia (HP:0003175)2.55313551
39Focal motor seizures (HP:0011153)2.50969539
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49744240
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.45593406
42Widely spaced teeth (HP:0000687)2.45079307
43Rhinitis (HP:0012384)2.42609938
44Limb dystonia (HP:0002451)2.42193589
45Tubulointerstitial nephritis (HP:0001970)2.41000144
46Bell-shaped thorax (HP:0001591)2.38448552
47Hepatosplenomegaly (HP:0001433)2.37081938
48Aplasia involving bones of the extremities (HP:0009825)2.34904657
49Aplasia involving bones of the upper limbs (HP:0009823)2.34904657
50Aplasia of the phalanges of the hand (HP:0009802)2.34904657
51Generalized aminoaciduria (HP:0002909)2.29008657
52Hemoptysis (HP:0002105)2.28693045
53Polyphagia (HP:0002591)2.28193515
54Gangrene (HP:0100758)2.26780307
55Aortic aneurysm (HP:0004942)2.23582971
56Paresthesia (HP:0003401)2.20740989
57Lower limb amyotrophy (HP:0007210)2.19887589
58Vascular tortuosity (HP:0004948)2.17706509
59Decreased central vision (HP:0007663)2.17258873
60Encephalitis (HP:0002383)2.14561635
61Chronic sinusitis (HP:0011109)2.14290979
62Chronic otitis media (HP:0000389)2.13251287
63Vertigo (HP:0002321)2.12281945
64Keratitis (HP:0000491)2.11103991
65Nasal polyposis (HP:0100582)2.09532669
66Glomerulopathy (HP:0100820)2.05074482
67Polyneuropathy (HP:0001271)2.03909058
68Bulbous nose (HP:0000414)2.00097342
69Spontaneous abortion (HP:0005268)1.98394812
70Spontaneous hematomas (HP:0007420)1.98120812
71Arterial tortuosity (HP:0005116)1.96645764
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94742704
73Pulmonary infiltrates (HP:0002113)1.93617684
74Horizontal nystagmus (HP:0000666)1.88171564
75Long toe (HP:0010511)1.85820077
762-3 toe syndactyly (HP:0004691)1.82974113
77Hypoplastic iliac wings (HP:0002866)1.82588140
78Hypoplastic nipples (HP:0002557)1.82513187
79Abnormality of the dental root (HP:0006486)1.81106572
80Taurodontia (HP:0000679)1.81106572
81Abnormality of permanent molar morphology (HP:0011071)1.81106572
82Bruising susceptibility (HP:0000978)1.79156920
83Thrombophlebitis (HP:0004418)1.77986981
84Abnormality of the endocardium (HP:0004306)1.76473356
85Abnormality of the nasal mucosa (HP:0000433)1.74519596
86Abnormality of the pubic bones (HP:0003172)1.74015569
87Interstitial pulmonary disease (HP:0006530)1.71271706
88Thyroid carcinoma (HP:0002890)1.70448551
89Absent speech (HP:0001344)1.67549023
90Abnormality of molar (HP:0011077)1.64955517
91Abnormality of molar morphology (HP:0011070)1.64955517
92Abnormality of the dental pulp (HP:0006479)1.64083758
93Biliary tract neoplasm (HP:0100574)1.62912361
94Poikilocytosis (HP:0004447)1.61115679
95Abnormality of the pericardium (HP:0001697)1.59088569
96Pili torti (HP:0003777)1.58346043
97Abnormal pupillary function (HP:0007686)1.55086584
98Split foot (HP:0001839)1.55037431
99Submucous cleft hard palate (HP:0000176)1.54332630
100Abnormality of intracranial pressure (HP:0012640)1.54322958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.43101182
2MAP2K65.11381645
3MARK13.04984252
4MAP3K122.68443391
5MAPKAPK32.50360899
6MST42.38026144
7EPHA32.29758804
8AKT32.26469216
9TNIK2.25837025
10MYLK2.23701792
11CASK2.12951876
12MUSK1.93276855
13TAOK31.82454218
14PRKD31.77192169
15MAPK131.66746196
16NUAK11.64312706
17DDR21.61350224
18STK391.52671530
19BRSK21.51354705
20WEE11.51045233
21PKN11.50620410
22WNK41.46712876
23PLK21.46664683
24PTK2B1.37965437
25EPHB21.32034886
26MINK11.24081003
27CAMK1G1.21200953
28BMX1.20762192
29TGFBR21.17782148
30IRAK11.16072772
31JAK11.11883398
32PRKCH1.10367164
33LATS11.03970326
34NLK0.99568703
35FGFR20.99341270
36CSNK1G20.91454410
37CSNK1G30.87415471
38PRKD20.86525526
39ACVR1B0.84876301
40SGK20.83191648
41ROCK10.81721925
42TXK0.79948810
43TRIM280.74574500
44NTRK20.74485122
45JAK30.73053946
46CSNK1G10.72443395
47GSK3A0.71106199
48MAP3K110.69372953
49CSNK1A1L0.68754246
50DYRK20.68254346
51CSF1R0.68250216
52WNK30.67291356
53EPHB10.66516796
54INSRR0.66173210
55FGFR30.65204935
56MAP3K10.65131359
57TIE10.64881604
58CAMK2A0.63537495
59MAP4K20.62652217
60FRK0.61712569
61GRK50.60197625
62NEK10.58818059
63ABL20.58732409
64SGK30.58167720
65MKNK20.57426224
66FER0.56720858
67KSR10.55656419
68STK30.54886833
69FGFR10.54525406
70BCR0.52636851
71SGK4940.50371238
72SGK2230.50371238
73PRKCG0.50075575
74PRKCE0.49782941
75MAPK150.49368888
76ROCK20.48996803
77MAP3K40.47718402
78PDGFRB0.46164755
79MAP3K140.45987449
80CHUK0.44197943
81ILK0.43998804
82CAMK2D0.43544807
83ADRBK10.43182382
84PHKG20.42869363
85PHKG10.42869363
86CCNB10.42764391
87DMPK0.41686514
88TEC0.41580543
89BTK0.40418672
90ERBB40.39802792
91NTRK10.38958619
92IKBKB0.37917050
93PRKG10.36569631
94PIK3CG0.35882736
95CAMKK20.35564866
96EPHA40.35442058
97CAMK2G0.34244904
98STK380.33970872
99ERBB20.33258525
100TYK20.32522479

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.14840181
2Platelet activation_Homo sapiens_hsa046112.86344364
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.73053352
4Nitrogen metabolism_Homo sapiens_hsa009102.66262001
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.55884855
6ECM-receptor interaction_Homo sapiens_hsa045122.22622206
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98559004
8Sulfur metabolism_Homo sapiens_hsa009201.94043735
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.82744514
10Caffeine metabolism_Homo sapiens_hsa002321.76185906
11Jak-STAT signaling pathway_Homo sapiens_hsa046301.70381825
12Phototransduction_Homo sapiens_hsa047441.59261482
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58497176
14Serotonergic synapse_Homo sapiens_hsa047261.58495124
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49967805
16Hematopoietic cell lineage_Homo sapiens_hsa046401.47451789
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41265548
18Propanoate metabolism_Homo sapiens_hsa006401.39476394
19Glycerolipid metabolism_Homo sapiens_hsa005611.33705715
20Glutamatergic synapse_Homo sapiens_hsa047241.25847109
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23493589
22Linoleic acid metabolism_Homo sapiens_hsa005911.22811349
23Gap junction_Homo sapiens_hsa045401.18809426
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.15269508
25Taste transduction_Homo sapiens_hsa047421.14596775
26Circadian entrainment_Homo sapiens_hsa047131.13275779
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09066683
28Olfactory transduction_Homo sapiens_hsa047401.08887764
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07398938
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06872610
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05357384
32Chemokine signaling pathway_Homo sapiens_hsa040621.04024933
33Endocytosis_Homo sapiens_hsa041441.03640247
34Dorso-ventral axis formation_Homo sapiens_hsa043201.02872695
35beta-Alanine metabolism_Homo sapiens_hsa004101.00526854
36Morphine addiction_Homo sapiens_hsa050320.99883403
37Nicotine addiction_Homo sapiens_hsa050330.97754957
38Dopaminergic synapse_Homo sapiens_hsa047280.94781972
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90192520
40Focal adhesion_Homo sapiens_hsa045100.90093303
41Arachidonic acid metabolism_Homo sapiens_hsa005900.89884550
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.86903258
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86655758
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85614231
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85486584
46Collecting duct acid secretion_Homo sapiens_hsa049660.85484197
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84318767
48Ether lipid metabolism_Homo sapiens_hsa005650.84149530
49MAPK signaling pathway_Homo sapiens_hsa040100.82875173
50Dilated cardiomyopathy_Homo sapiens_hsa054140.82625033
51Malaria_Homo sapiens_hsa051440.80634810
52Vitamin B6 metabolism_Homo sapiens_hsa007500.78539411
53GABAergic synapse_Homo sapiens_hsa047270.76733529
54Ras signaling pathway_Homo sapiens_hsa040140.75788690
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.74705954
56Calcium signaling pathway_Homo sapiens_hsa040200.70721674
57Fatty acid elongation_Homo sapiens_hsa000620.70088672
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69304359
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69281799
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67447944
61Cocaine addiction_Homo sapiens_hsa050300.66339570
62Protein export_Homo sapiens_hsa030600.65769456
63African trypanosomiasis_Homo sapiens_hsa051430.65459390
64Pancreatic cancer_Homo sapiens_hsa052120.63696835
65Long-term depression_Homo sapiens_hsa047300.63690330
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62231765
67Choline metabolism in cancer_Homo sapiens_hsa052310.61769097
68Shigellosis_Homo sapiens_hsa051310.61504182
69Fat digestion and absorption_Homo sapiens_hsa049750.61135904
70Notch signaling pathway_Homo sapiens_hsa043300.60953464
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60771678
72Basal cell carcinoma_Homo sapiens_hsa052170.58860163
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58648867
74Butanoate metabolism_Homo sapiens_hsa006500.57765856
75Regulation of autophagy_Homo sapiens_hsa041400.57201911
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57188978
77Cholinergic synapse_Homo sapiens_hsa047250.56707222
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.54890561
79TGF-beta signaling pathway_Homo sapiens_hsa043500.54844981
80Ovarian steroidogenesis_Homo sapiens_hsa049130.54388965
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54343472
82Axon guidance_Homo sapiens_hsa043600.53932307
83Rap1 signaling pathway_Homo sapiens_hsa040150.53697478
84Hepatitis B_Homo sapiens_hsa051610.52692389
85Alcoholism_Homo sapiens_hsa050340.51279568
86Pertussis_Homo sapiens_hsa051330.50827705
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50058870
88Fatty acid metabolism_Homo sapiens_hsa012120.49575356
89Pancreatic secretion_Homo sapiens_hsa049720.47842330
90Legionellosis_Homo sapiens_hsa051340.47083153
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45715732
92MicroRNAs in cancer_Homo sapiens_hsa052060.45254582
93Circadian rhythm_Homo sapiens_hsa047100.44628094
94Measles_Homo sapiens_hsa051620.44430638
95Pathways in cancer_Homo sapiens_hsa052000.43934227
96Endometrial cancer_Homo sapiens_hsa052130.43744550
97Amphetamine addiction_Homo sapiens_hsa050310.42991277
98Melanoma_Homo sapiens_hsa052180.42762025
99Hippo signaling pathway_Homo sapiens_hsa043900.42697748
100Adherens junction_Homo sapiens_hsa045200.42599873

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