ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of integrin-mediated signaling pathway (GO:2001044)	5.18353515
2	thrombin receptor signaling pathway (GO:0070493)	5.08009981
3	protein neddylation (GO:0045116)	5.04704020
4	negative regulation of protein localization to cell surface (GO:2000009)	4.38696674
5	L-fucose catabolic process (GO:0042355)	4.21997491
6	fucose catabolic process (GO:0019317)	4.21997491
7	L-fucose metabolic process (GO:0042354)	4.21997491
8	pyrimidine nucleobase catabolic process (GO:0006208)	4.10770110
9	mitochondrial calcium ion transport (GO:0006851)	4.06815821
10	histone H3-K36 demethylation (GO:0070544)	4.01778287
11	negative regulation of thymocyte apoptotic process (GO:0070244)	3.87790487
12	cilium or flagellum-dependent cell motility (GO:0001539)	3.84574145
13	negative regulation of heart rate (GO:0010459)	3.73561624
14	regulation of immunoglobulin secretion (GO:0051023)	3.73096438
15	fatty acid elongation (GO:0030497)	3.70992120
16	extracellular fibril organization (GO:0043206)	3.68069322
17	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.66829999
18	long-chain fatty acid biosynthetic process (GO:0042759)	3.63337041
19	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.57583955
20	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.55244947
21	adenosine receptor signaling pathway (GO:0001973)	3.55175754
22	cullin deneddylation (GO:0010388)	3.52855535
23	neutrophil activation involved in immune response (GO:0002283)	3.48652394
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47255031
25	negative regulation of appetite (GO:0032099)	3.46637172
26	negative regulation of response to food (GO:0032096)	3.46637172
27	behavioral response to cocaine (GO:0048148)	3.43646975
28	protein localization to cilium (GO:0061512)	3.41979580
29	negative regulation of platelet activation (GO:0010544)	3.34256038
30	negative regulation of neurotransmitter transport (GO:0051589)	3.27840459
31	cilium movement (GO:0003341)	3.21751708
32	regulation of meiosis I (GO:0060631)	3.21057727
33	sleep (GO:0030431)	3.20028816
34	sequestering of actin monomers (GO:0042989)	3.16215654
35	angiogenesis involved in wound healing (GO:0060055)	3.12919389
36	microtubule depolymerization (GO:0007019)	3.11388804
37	fibril organization (GO:0097435)	3.06386533
38	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.05514856
39	protein deneddylation (GO:0000338)	3.05446108
40	regulation of platelet activation (GO:0010543)	3.04113784
41	epithelial cilium movement (GO:0003351)	3.00924505
42	nucleobase catabolic process (GO:0046113)	2.98711548
43	mesodermal cell differentiation (GO:0048333)	2.93647776
44	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.93508735
45	left/right pattern formation (GO:0060972)	2.91247373
46	lung lobe morphogenesis (GO:0060463)	2.90623018
47	regulation of penile erection (GO:0060405)	2.89900951
48	negative regulation of norepinephrine secretion (GO:0010700)	2.89242214
49	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.88919444
50	axonemal dynein complex assembly (GO:0070286)	2.88295730
51	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.88066394
52	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.87796042
53	regulation of sensory perception (GO:0051931)	2.85365658
54	regulation of sensory perception of pain (GO:0051930)	2.85365658
55	response to gravity (GO:0009629)	2.85040762
56	positive regulation of endothelial cell differentiation (GO:0045603)	2.84495359
57	regulation of memory T cell differentiation (GO:0043380)	2.81966783
58	regulation of platelet aggregation (GO:0090330)	2.80528097
59	positive regulation of p38MAPK cascade (GO:1900745)	2.80329885
60	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.79321772
61	regulation of T-helper 1 cell differentiation (GO:0045625)	2.78756558
62	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.78034565
63	response to pheromone (GO:0019236)	2.72866055
64	mechanosensory behavior (GO:0007638)	2.70240757
65	endocytic recycling (GO:0032456)	2.70026228
66	negative chemotaxis (GO:0050919)	2.68947769
67	fusion of sperm to egg plasma membrane (GO:0007342)	2.67299562
68	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.67212853
69	regulation of norepinephrine secretion (GO:0014061)	2.67182656
70	regulation of cilium movement (GO:0003352)	2.66956998
71	autophagic vacuole fusion (GO:0000046)	2.66786886
72	regulation of integrin activation (GO:0033623)	2.64756686
73	low-density lipoprotein particle remodeling (GO:0034374)	2.62596229
74	platelet aggregation (GO:0070527)	2.62179389
75	regulation of axon guidance (GO:1902667)	2.59435580
76	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.57537576
77	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.57537576
78	skeletal muscle tissue regeneration (GO:0043403)	2.57323312
79	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.55928684
80	JAK-STAT cascade (GO:0007259)	2.55786373
81	fibroblast migration (GO:0010761)	2.53729854
82	protein localization to synapse (GO:0035418)	2.52433083
83	regulation of pigment cell differentiation (GO:0050932)	2.52269773
84	mitochondrial calcium ion homeostasis (GO:0051560)	2.52198919
85	negative regulation of heart contraction (GO:0045822)	2.51398530
86	regulation of phospholipid biosynthetic process (GO:0071071)	2.51347915
87	chemosensory behavior (GO:0007635)	2.50149110
88	negative regulation of execution phase of apoptosis (GO:1900118)	2.49799632
89	metanephric mesenchyme development (GO:0072075)	2.48744496
90	positive regulation of Rho protein signal transduction (GO:0035025)	2.45887508
91	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	2.44949189
92	positive regulation of hemostasis (GO:1900048)	2.44919098
93	positive regulation of blood coagulation (GO:0030194)	2.44919098
94	purinergic receptor signaling pathway (GO:0035587)	2.44416873
95	regulation of appetite (GO:0032098)	2.44000005
96	alanine transport (GO:0032328)	2.43957931
97	platelet degranulation (GO:0002576)	2.41638076
98	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.41362795
99	negative regulation of T-helper cell differentiation (GO:0045623)	2.41362795
100	blood coagulation, intrinsic pathway (GO:0007597)	2.39505543

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	4.06969105
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.58449034
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.98349632
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.81259926
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.71592597
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.68684142
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.60501374
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.50717041
9	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.49501655
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.37432413
11	VDR_22108803_ChIP-Seq_LS180_Human	2.33708328
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29932951
13	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.17917919
14	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.13481730
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96809266
16	FUS_26573619_Chip-Seq_HEK293_Human	1.90751300
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.87833940
18	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.84943275
19	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.84017695
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.82439459
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.81827141
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.70771061
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70535007
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.66206228
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64069352
26	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63078351
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61966769
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59086944
29	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.57994146
30	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.51486546
31	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.51486546
32	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.50481344
33	EWS_26573619_Chip-Seq_HEK293_Human	1.48032014
34	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.47627067
35	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.46367711
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.44236656
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.43106673
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41258507
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41024660
40	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.38711380
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38086096
42	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.37496728
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37493557
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36135203
45	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.35700521
46	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.35518047
47	CJUN_26792858_Chip-Seq_BT549_Human	1.33950058
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33191009
49	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29998617
50	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.29553500
51	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.29130708
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27504117
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26298149
54	P53_22387025_ChIP-Seq_ESCs_Mouse	1.26155127
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25587023
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25509034
57	STAT3_23295773_ChIP-Seq_U87_Human	1.22563690
58	P300_19829295_ChIP-Seq_ESCs_Human	1.22309689
59	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.22285954
60	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.21091696
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20656485
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16327138
63	ZNF274_21170338_ChIP-Seq_K562_Hela	1.15082663
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.14301451
65	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12829748
66	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.11967106
67	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11653052
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11553916
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.09836349
70	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.09741237
71	* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09292876
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09059836
73	RUNX_20019798_ChIP-Seq_JUKART_Human	1.07958271
74	AR_25329375_ChIP-Seq_VCAP_Human	1.07828796
75	P300_18555785_Chip-Seq_ESCs_Mouse	1.06023919
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03952528
77	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03567611
78	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.01781601
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01552475
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01552475
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01051846
82	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99949775
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99493885
84	TCF4_23295773_ChIP-Seq_U87_Human	0.99303450
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98563364
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.97759771
87	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.97711985
88	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.96448639
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96255741
90	TP63_23658742_ChIP-Seq_EP156T_Human	0.94433898
91	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.94047743
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.93428642
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.92947456
94	TBL1_22424771_ChIP-Seq_293T_Human	0.92733488
95	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92021417
96	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.91874351
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.91710992
98	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.91673068
99	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.91222719
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90181862

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	6.18977872
2	MP0005464_abnormal_platelet_physiology	4.14699721
3	MP0003136_yellow_coat_color	4.13052241
4	MP0001968_abnormal_touch/_nociception	3.86504706
5	MP0002735_abnormal_chemical_nociception	3.62347591
6	MP0008004_abnormal_stomach_pH	2.83411545
7	MP0010352_gastrointestinal_tract_polyps	2.71754151
8	MP0003283_abnormal_digestive_organ	2.63797918
9	MP0003303_peritoneal_inflammation	2.35063024
10	MP0001849_ear_inflammation	2.14682187
11	MP0008775_abnormal_heart_ventricle	2.04058957
12	MP0005171_absent_coat_pigmentation	1.98481135
13	MP0005187_abnormal_penis_morphology	1.97146448
14	MP0004510_myositis	1.97042182
15	MP0002733_abnormal_thermal_nociception	1.92311066
16	MP0009785_altered_susceptibility_to	1.89683755
17	MP0005623_abnormal_meninges_morphology	1.81445402
18	MP0002102_abnormal_ear_morphology	1.74128418
19	MP0010368_abnormal_lymphatic_system	1.65970977
20	MP0000566_synostosis	1.65837235
21	MP0004084_abnormal_cardiac_muscle	1.59615619
22	MP0001879_abnormal_lymphatic_vessel	1.55747190
23	MP0001970_abnormal_pain_threshold	1.55743706
24	MP0000372_irregular_coat_pigmentation	1.49050569
25	MP0003724_increased_susceptibility_to	1.48130222
26	MP0005409_darkened_coat_color	1.47128234
27	MP0008872_abnormal_physiological_respon	1.46792091
28	MP0003950_abnormal_plasma_membrane	1.43562988
29	MP0005367_renal/urinary_system_phenotyp	1.41583334
30	MP0000516_abnormal_urinary_system	1.41583334
31	MP0000579_abnormal_nail_morphology	1.39510759
32	MP0001958_emphysema	1.38567432
33	MP0002148_abnormal_hypersensitivity_rea	1.26331620
34	MP0002734_abnormal_mechanical_nocicepti	1.25777510
35	MP0005671_abnormal_response_to	1.25293582
36	MP0000534_abnormal_ureter_morphology	1.24356791
37	MP0000465_gastrointestinal_hemorrhage	1.23980551
38	MP0000230_abnormal_systemic_arterial	1.22477900
39	MP0001299_abnormal_eye_distance/	1.21492160
40	MP0002234_abnormal_pharynx_morphology	1.21056188
41	MP0002095_abnormal_skin_pigmentation	1.16716673
42	MP0001835_abnormal_antigen_presentation	1.13952383
43	MP0005164_abnormal_response_to	1.13326651
44	MP0006138_congestive_heart_failure	1.12534897
45	MP0001501_abnormal_sleep_pattern	1.10000239
46	MP0004142_abnormal_muscle_tone	1.06924381
47	MP0005248_abnormal_Harderian_gland	1.06526131
48	MP0004883_abnormal_blood_vessel	1.06263387
49	MP0000427_abnormal_hair_cycle	1.05159618
50	MP0010155_abnormal_intestine_physiology	1.03070789
51	MP0004859_abnormal_synaptic_plasticity	1.02772499
52	MP0006054_spinal_hemorrhage	1.01786881
53	MP0009780_abnormal_chondrocyte_physiolo	1.00794281
54	MP0004036_abnormal_muscle_relaxation	0.97129832
55	MP0005084_abnormal_gallbladder_morpholo	0.95569760
56	MP0009250_abnormal_appendicular_skeleto	0.95177076
57	MP0008875_abnormal_xenobiotic_pharmacok	0.94998950
58	MP0008569_lethality_at_weaning	0.93821606
59	MP0002638_abnormal_pupillary_reflex	0.92235919
60	MP0003566_abnormal_cell_adhesion	0.91914779
61	MP0003091_abnormal_cell_migration	0.89979004
62	MP0003436_decreased_susceptibility_to	0.89653922
63	MP0004381_abnormal_hair_follicle	0.88963242
64	MP0002295_abnormal_pulmonary_circulatio	0.84578650
65	MP0001663_abnormal_digestive_system	0.84432408
66	MP0005535_abnormal_body_temperature	0.83535436
67	MP0000647_abnormal_sebaceous_gland	0.83135384
68	MP0001544_abnormal_cardiovascular_syste	0.82104364
69	MP0005385_cardiovascular_system_phenoty	0.82104364
70	MP0005167_abnormal_blood-brain_barrier	0.81774566
71	MP0002177_abnormal_outer_ear	0.81649235
72	MP0001533_abnormal_skeleton_physiology	0.81342376
73	MP0008438_abnormal_cutaneous_collagen	0.80357881
74	MP0001853_heart_inflammation	0.79556578
75	MP0005275_abnormal_skin_tensile	0.79107242
76	MP0005410_abnormal_fertilization	0.79064504
77	MP0003011_delayed_dark_adaptation	0.78655299
78	MP0002282_abnormal_trachea_morphology	0.78629942
79	MP0000343_altered_response_to	0.78171623
80	MP0005000_abnormal_immune_tolerance	0.77428371
81	MP0004885_abnormal_endolymph	0.76758378
82	MP0000778_abnormal_nervous_system	0.74009767
83	MP0005023_abnormal_wound_healing	0.73753228
84	MP0000015_abnormal_ear_pigmentation	0.73366914
85	MP0002133_abnormal_respiratory_system	0.72446096
86	MP0005388_respiratory_system_phenotype	0.72446096
87	MP0001542_abnormal_bone_strength	0.72368333
88	MP0004215_abnormal_myocardial_fiber	0.71707975
89	MP0008789_abnormal_olfactory_epithelium	0.70828614
90	MP0003045_fibrosis	0.66815063
91	MP0002653_abnormal_ependyma_morphology	0.66366766
92	MP0006276_abnormal_autonomic_nervous	0.65307920
93	MP0000249_abnormal_blood_vessel	0.64497301
94	MP0002233_abnormal_nose_morphology	0.64150564
95	MP0002128_abnormal_blood_circulation	0.63960999
96	MP0003880_abnormal_central_pattern	0.63922446
97	MP0002557_abnormal_social/conspecific_i	0.62528648
98	MP0005390_skeleton_phenotype	0.62441976
99	MP0008961_abnormal_basal_metabolism	0.62096186
100	MP0004484_altered_response_of	0.61968385

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retrobulbar optic neuritis (HP:0100654)	6.21028459
2	Optic neuritis (HP:0100653)	6.21028459
3	Orchitis (HP:0100796)	5.46358827
4	Increased mean platelet volume (HP:0011877)	5.33748727
5	Prolonged bleeding time (HP:0003010)	5.23924504
6	Menorrhagia (HP:0000132)	5.11318756
7	Abnormal platelet volume (HP:0011876)	4.78991966
8	Keratoconjunctivitis sicca (HP:0001097)	4.70511283
9	Myositis (HP:0100614)	4.51951532
10	Tetraparesis (HP:0002273)	4.40575011
11	Keratoconjunctivitis (HP:0001096)	4.25336094
12	Petechiae (HP:0000967)	4.09363365
13	Epistaxis (HP:0000421)	4.03054786
14	Abnormal ciliary motility (HP:0012262)	3.99882226
15	Hyperlipoproteinemia (HP:0010980)	3.82006947
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.76917912
17	Abnormal respiratory motile cilium morphology (HP:0005938)	3.76917912
18	Purpura (HP:0000979)	3.75604221
19	Joint swelling (HP:0001386)	3.51231933
20	Gingival bleeding (HP:0000225)	3.36232096
21	Abnormal platelet function (HP:0011869)	3.16694729
22	Impaired platelet aggregation (HP:0003540)	3.16694729
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.16394527
24	Absent/shortened dynein arms (HP:0200106)	3.16394527
25	Portal hypertension (HP:0001409)	3.12649472
26	Arterial thrombosis (HP:0004420)	3.11650774
27	Dyschromatopsia (HP:0007641)	3.02904938
28	Abnormal respiratory motile cilium physiology (HP:0012261)	2.98790099
29	Tubulointerstitial fibrosis (HP:0005576)	2.91747476
30	Tubulointerstitial abnormality (HP:0001969)	2.88013788
31	Abnormality of the hepatic vasculature (HP:0006707)	2.77153610
32	Upper limb muscle weakness (HP:0003484)	2.76682902
33	Papillary thyroid carcinoma (HP:0002895)	2.76375670
34	Fibular aplasia (HP:0002990)	2.74864809
35	Abnormal auditory evoked potentials (HP:0006958)	2.73298526
36	Long clavicles (HP:0000890)	2.66001107
37	Abnormality of the ischium (HP:0003174)	2.56452725
38	Hypoplastic ischia (HP:0003175)	2.55313551
39	Focal motor seizures (HP:0011153)	2.50969539
40	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.49744240
41	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.45593406
42	Widely spaced teeth (HP:0000687)	2.45079307
43	Rhinitis (HP:0012384)	2.42609938
44	Limb dystonia (HP:0002451)	2.42193589
45	Tubulointerstitial nephritis (HP:0001970)	2.41000144
46	Bell-shaped thorax (HP:0001591)	2.38448552
47	Hepatosplenomegaly (HP:0001433)	2.37081938
48	Aplasia involving bones of the upper limbs (HP:0009823)	2.34904657
49	Aplasia of the phalanges of the hand (HP:0009802)	2.34904657
50	Aplasia involving bones of the extremities (HP:0009825)	2.34904657
51	Generalized aminoaciduria (HP:0002909)	2.29008657
52	Hemoptysis (HP:0002105)	2.28693045
53	Polyphagia (HP:0002591)	2.28193515
54	Gangrene (HP:0100758)	2.26780307
55	Aortic aneurysm (HP:0004942)	2.23582971
56	Paresthesia (HP:0003401)	2.20740989
57	Lower limb amyotrophy (HP:0007210)	2.19887589
58	Vascular tortuosity (HP:0004948)	2.17706509
59	Decreased central vision (HP:0007663)	2.17258873
60	Encephalitis (HP:0002383)	2.14561635
61	Chronic sinusitis (HP:0011109)	2.14290979
62	Chronic otitis media (HP:0000389)	2.13251287
63	Vertigo (HP:0002321)	2.12281945
64	Keratitis (HP:0000491)	2.11103991
65	Nasal polyposis (HP:0100582)	2.09532669
66	Glomerulopathy (HP:0100820)	2.05074482
67	Polyneuropathy (HP:0001271)	2.03909058
68	Bulbous nose (HP:0000414)	2.00097342
69	Spontaneous abortion (HP:0005268)	1.98394812
70	Spontaneous hematomas (HP:0007420)	1.98120812
71	Arterial tortuosity (HP:0005116)	1.96645764
72	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.94742704
73	Pulmonary infiltrates (HP:0002113)	1.93617684
74	Horizontal nystagmus (HP:0000666)	1.88171564
75	Long toe (HP:0010511)	1.85820077
76	2-3 toe syndactyly (HP:0004691)	1.82974113
77	Hypoplastic iliac wings (HP:0002866)	1.82588140
78	Hypoplastic nipples (HP:0002557)	1.82513187
79	Abnormality of permanent molar morphology (HP:0011071)	1.81106572
80	Abnormality of the dental root (HP:0006486)	1.81106572
81	Taurodontia (HP:0000679)	1.81106572
82	Bruising susceptibility (HP:0000978)	1.79156920
83	Thrombophlebitis (HP:0004418)	1.77986981
84	Abnormality of the endocardium (HP:0004306)	1.76473356
85	Abnormality of the nasal mucosa (HP:0000433)	1.74519596
86	Abnormality of the pubic bones (HP:0003172)	1.74015569
87	Interstitial pulmonary disease (HP:0006530)	1.71271706
88	Thyroid carcinoma (HP:0002890)	1.70448551
89	Absent speech (HP:0001344)	1.67549023
90	Abnormality of molar morphology (HP:0011070)	1.64955517
91	Abnormality of molar (HP:0011077)	1.64955517
92	Abnormality of the dental pulp (HP:0006479)	1.64083758
93	Biliary tract neoplasm (HP:0100574)	1.62912361
94	Poikilocytosis (HP:0004447)	1.61115679
95	Abnormality of the pericardium (HP:0001697)	1.59088569
96	Pili torti (HP:0003777)	1.58346043
97	Abnormal pupillary function (HP:0007686)	1.55086584
98	Split foot (HP:0001839)	1.55037431
99	Submucous cleft hard palate (HP:0000176)	1.54332630
100	Abnormality of intracranial pressure (HP:0012640)	1.54322958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	6.43101182
2	MAP2K6	5.11381645
3	MARK1	3.04984252
4	MAP3K12	2.68443391
5	MAPKAPK3	2.50360899
6	MST4	2.38026144
7	EPHA3	2.29758804
8	AKT3	2.26469216
9	TNIK	2.25837025
10	MYLK	2.23701792
11	CASK	2.12951876
12	MUSK	1.93276855
13	TAOK3	1.82454218
14	PRKD3	1.77192169
15	MAPK13	1.66746196
16	NUAK1	1.64312706
17	DDR2	1.61350224
18	STK39	1.52671530
19	BRSK2	1.51354705
20	WEE1	1.51045233
21	PKN1	1.50620410
22	WNK4	1.46712876
23	PLK2	1.46664683
24	PTK2B	1.37965437
25	EPHB2	1.32034886
26	MINK1	1.24081003
27	CAMK1G	1.21200953
28	BMX	1.20762192
29	TGFBR2	1.17782148
30	IRAK1	1.16072772
31	JAK1	1.11883398
32	PRKCH	1.10367164
33	LATS1	1.03970326
34	NLK	0.99568703
35	FGFR2	0.99341270
36	CSNK1G2	0.91454410
37	CSNK1G3	0.87415471
38	PRKD2	0.86525526
39	ACVR1B	0.84876301
40	SGK2	0.83191648
41	ROCK1	0.81721925
42	TXK	0.79948810
43	TRIM28	0.74574500
44	NTRK2	0.74485122
45	JAK3	0.73053946
46	CSNK1G1	0.72443395
47	GSK3A	0.71106199
48	MAP3K11	0.69372953
49	CSNK1A1L	0.68754246
50	DYRK2	0.68254346
51	CSF1R	0.68250216
52	WNK3	0.67291356
53	EPHB1	0.66516796
54	INSRR	0.66173210
55	FGFR3	0.65204935
56	MAP3K1	0.65131359
57	TIE1	0.64881604
58	CAMK2A	0.63537495
59	MAP4K2	0.62652217
60	FRK	0.61712569
61	GRK5	0.60197625
62	NEK1	0.58818059
63	ABL2	0.58732409
64	SGK3	0.58167720
65	MKNK2	0.57426224
66	FER	0.56720858
67	KSR1	0.55656419
68	STK3	0.54886833
69	FGFR1	0.54525406
70	BCR	0.52636851
71	SGK223	0.50371238
72	SGK494	0.50371238
73	PRKCG	0.50075575
74	PRKCE	0.49782941
75	MAPK15	0.49368888
76	ROCK2	0.48996803
77	MAP3K4	0.47718402
78	PDGFRB	0.46164755
79	MAP3K14	0.45987449
80	CHUK	0.44197943
81	ILK	0.43998804
82	CAMK2D	0.43544807
83	ADRBK1	0.43182382
84	PHKG2	0.42869363
85	PHKG1	0.42869363
86	CCNB1	0.42764391
87	DMPK	0.41686514
88	TEC	0.41580543
89	BTK	0.40418672
90	ERBB4	0.39802792
91	NTRK1	0.38958619
92	IKBKB	0.37917050
93	PRKG1	0.36569631
94	PIK3CG	0.35882736
95	CAMKK2	0.35564866
96	EPHA4	0.35442058
97	CAMK2G	0.34244904
98	STK38	0.33970872
99	ERBB2	0.33258525
100	TYK2	0.32522479

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.14840181
2	Platelet activation_Homo sapiens_hsa04611	2.86344364
3	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.73053352
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.66262001
5	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.55884855
6	ECM-receptor interaction_Homo sapiens_hsa04512	2.22622206
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98559004
8	Sulfur metabolism_Homo sapiens_hsa00920	1.94043735
9	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.82744514
10	Caffeine metabolism_Homo sapiens_hsa00232	1.76185906
11	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.70381825
12	Phototransduction_Homo sapiens_hsa04744	1.59261482
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.58497176
14	Serotonergic synapse_Homo sapiens_hsa04726	1.58495124
15	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.49967805
16	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.47451789
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41265548
18	Propanoate metabolism_Homo sapiens_hsa00640	1.39476394
19	Glycerolipid metabolism_Homo sapiens_hsa00561	1.33705715
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.25847109
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23493589
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22811349
23	Gap junction_Homo sapiens_hsa04540	1.18809426
24	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.15269508
25	Taste transduction_Homo sapiens_hsa04742	1.14596775
26	Circadian entrainment_Homo sapiens_hsa04713	1.13275779
27	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.09066683
28	Olfactory transduction_Homo sapiens_hsa04740	1.08887764
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07398938
30	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.06872610
31	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.05357384
32	Chemokine signaling pathway_Homo sapiens_hsa04062	1.04024933
33	Endocytosis_Homo sapiens_hsa04144	1.03640247
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02872695
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.00526854
36	Morphine addiction_Homo sapiens_hsa05032	0.99883403
37	Nicotine addiction_Homo sapiens_hsa05033	0.97754957
38	Dopaminergic synapse_Homo sapiens_hsa04728	0.94781972
39	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.90192520
40	Focal adhesion_Homo sapiens_hsa04510	0.90093303
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89884550
42	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.86903258
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86655758
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85614231
45	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.85486584
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85484197
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84318767
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.84149530
49	MAPK signaling pathway_Homo sapiens_hsa04010	0.82875173
50	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.82625033
51	Malaria_Homo sapiens_hsa05144	0.80634810
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78539411
53	GABAergic synapse_Homo sapiens_hsa04727	0.76733529
54	Ras signaling pathway_Homo sapiens_hsa04014	0.75788690
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74705954
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.70721674
57	Fatty acid elongation_Homo sapiens_hsa00062	0.70088672
58	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.69304359
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69281799
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67447944
61	Cocaine addiction_Homo sapiens_hsa05030	0.66339570
62	Protein export_Homo sapiens_hsa03060	0.65769456
63	African trypanosomiasis_Homo sapiens_hsa05143	0.65459390
64	Pancreatic cancer_Homo sapiens_hsa05212	0.63696835
65	Long-term depression_Homo sapiens_hsa04730	0.63690330
66	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.62231765
67	Choline metabolism in cancer_Homo sapiens_hsa05231	0.61769097
68	Shigellosis_Homo sapiens_hsa05131	0.61504182
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.61135904
70	Notch signaling pathway_Homo sapiens_hsa04330	0.60953464
71	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.60771678
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.58860163
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58648867
74	Butanoate metabolism_Homo sapiens_hsa00650	0.57765856
75	Regulation of autophagy_Homo sapiens_hsa04140	0.57201911
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57188978
77	Cholinergic synapse_Homo sapiens_hsa04725	0.56707222
78	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.54890561
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.54844981
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54388965
81	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.54343472
82	Axon guidance_Homo sapiens_hsa04360	0.53932307
83	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53697478
84	Hepatitis B_Homo sapiens_hsa05161	0.52692389
85	Alcoholism_Homo sapiens_hsa05034	0.51279568
86	Pertussis_Homo sapiens_hsa05133	0.50827705
87	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.50058870
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.49575356
89	Pancreatic secretion_Homo sapiens_hsa04972	0.47842330
90	Legionellosis_Homo sapiens_hsa05134	0.47083153
91	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45715732
92	MicroRNAs in cancer_Homo sapiens_hsa05206	0.45254582
93	Circadian rhythm_Homo sapiens_hsa04710	0.44628094
94	Measles_Homo sapiens_hsa05162	0.44430638
95	Pathways in cancer_Homo sapiens_hsa05200	0.43934227
96	Endometrial cancer_Homo sapiens_hsa05213	0.43744550
97	Amphetamine addiction_Homo sapiens_hsa05031	0.42991277
98	Melanoma_Homo sapiens_hsa05218	0.42762025
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.42697748
100	Adherens junction_Homo sapiens_hsa04520	0.42599873

C2ORF66

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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