ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.92959857
2	protein complex biogenesis (GO:0070271)	4.19155225
3	respiratory chain complex IV assembly (GO:0008535)	4.17227275
4	platelet dense granule organization (GO:0060155)	4.16892248
5	cytochrome complex assembly (GO:0017004)	3.90825236
6	mitochondrial respiratory chain complex assembly (GO:0033108)	3.76534865
7	behavioral response to nicotine (GO:0035095)	3.75834419
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.75230810
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.67484030
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.67484030
11	NADH dehydrogenase complex assembly (GO:0010257)	3.67484030
12	regulation of hexokinase activity (GO:1903299)	3.57368117
13	regulation of glucokinase activity (GO:0033131)	3.57368117
14	preassembly of GPI anchor in ER membrane (GO:0016254)	3.54626099
15	mannosylation (GO:0097502)	3.52669000
16	DNA double-strand break processing (GO:0000729)	3.51508525
17	axoneme assembly (GO:0035082)	3.43914689
18	L-fucose catabolic process (GO:0042355)	3.40139809
19	fucose catabolic process (GO:0019317)	3.40139809
20	L-fucose metabolic process (GO:0042354)	3.40139809
21	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.34124208
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.33993063
23	protein neddylation (GO:0045116)	3.32197176
24	inositol phosphate catabolic process (GO:0071545)	3.20205565
25	cellular ketone body metabolic process (GO:0046950)	3.20142092
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.19808407
27	ATP synthesis coupled proton transport (GO:0015986)	3.19808407
28	epithelial cilium movement (GO:0003351)	3.19060247
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.08847774
30	centriole replication (GO:0007099)	3.08301711
31	regulation of cilium movement (GO:0003352)	3.06180398
32	ketone body metabolic process (GO:1902224)	3.05449182
33	negative regulation of telomere maintenance (GO:0032205)	3.03619075
34	protein K6-linked ubiquitination (GO:0085020)	3.01205938
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98695911
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.95909500
37	peptidyl-histidine modification (GO:0018202)	2.91336242
38	replication fork processing (GO:0031297)	2.91091135
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.90463440
40	indole-containing compound catabolic process (GO:0042436)	2.86835270
41	indolalkylamine catabolic process (GO:0046218)	2.86835270
42	tryptophan catabolic process (GO:0006569)	2.86835270
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85096622
44	indolalkylamine metabolic process (GO:0006586)	2.82138633
45	response to pheromone (GO:0019236)	2.82119593
46	protein polyglutamylation (GO:0018095)	2.82096794
47	adenosine metabolic process (GO:0046085)	2.82086947
48	inositol phosphate dephosphorylation (GO:0046855)	2.78633915
49	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.78633915
50	GPI anchor metabolic process (GO:0006505)	2.76254401
51	electron transport chain (GO:0022900)	2.72754079
52	ubiquinone biosynthetic process (GO:0006744)	2.71450917
53	protein localization to cilium (GO:0061512)	2.70862450
54	cytidine deamination (GO:0009972)	2.68003567
55	cytidine metabolic process (GO:0046087)	2.68003567
56	cytidine catabolic process (GO:0006216)	2.68003567
57	respiratory electron transport chain (GO:0022904)	2.67783743
58	sulfation (GO:0051923)	2.66768652
59	neuron fate determination (GO:0048664)	2.63632471
60	adaptation of signaling pathway (GO:0023058)	2.62841241
61	dopamine transport (GO:0015872)	2.61112141
62	C-terminal protein lipidation (GO:0006501)	2.60996152
63	aggressive behavior (GO:0002118)	2.60555599
64	anterograde synaptic vesicle transport (GO:0048490)	2.59167457
65	positive regulation of prostaglandin secretion (GO:0032308)	2.58901168
66	cilium morphogenesis (GO:0060271)	2.56032330
67	intraciliary transport (GO:0042073)	2.55585954
68	kynurenine metabolic process (GO:0070189)	2.54437867
69	prostate gland growth (GO:0060736)	2.53699945
70	nonmotile primary cilium assembly (GO:0035058)	2.52397220
71	polyol catabolic process (GO:0046174)	2.51539960
72	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.50568521
73	nephron epithelium morphogenesis (GO:0072088)	2.50204629
74	nephron tubule morphogenesis (GO:0072078)	2.50204629
75	piRNA metabolic process (GO:0034587)	2.48684600
76	protein-cofactor linkage (GO:0018065)	2.48568913
77	cilium movement (GO:0003341)	2.48493236
78	somite development (GO:0061053)	2.48405814
79	ubiquinone metabolic process (GO:0006743)	2.47996038
80	branched-chain amino acid catabolic process (GO:0009083)	2.47283637
81	dentate gyrus development (GO:0021542)	2.46054606
82	S-adenosylmethionine metabolic process (GO:0046500)	2.45463796
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.45181562
84	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.45181562
85	signal peptide processing (GO:0006465)	2.45143070
86	C-terminal protein amino acid modification (GO:0018410)	2.44065913
87	prenylation (GO:0097354)	2.43687734
88	protein prenylation (GO:0018342)	2.43687734
89	tryptophan metabolic process (GO:0006568)	2.43581836
90	base-excision repair, AP site formation (GO:0006285)	2.43201217
91	kidney morphogenesis (GO:0060993)	2.41827860
92	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.40834182
93	recombinational repair (GO:0000725)	2.40757898
94	double-strand break repair via homologous recombination (GO:0000724)	2.40070511
95	GPI anchor biosynthetic process (GO:0006506)	2.39380351
96	photoreceptor cell maintenance (GO:0045494)	2.37898941
97	regulation of meiosis I (GO:0060631)	2.37186827
98	regulation of B cell apoptotic process (GO:0002902)	2.34779539
99	cilium organization (GO:0044782)	2.33573474
100	DNA demethylation (GO:0080111)	2.31549659

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73430455
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.37834937
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.91413979
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.88414701
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.83912348
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.75821827
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.71962232
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61888523
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56485477
10	VDR_22108803_ChIP-Seq_LS180_Human	2.52184812
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48645429
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.36073820
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27160735
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.26623106
15	EWS_26573619_Chip-Seq_HEK293_Human	2.23879515
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11993093
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.07560877
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.06746672
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03845834
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.97901729
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.96570117
22	FUS_26573619_Chip-Seq_HEK293_Human	1.95333846
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95062515
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.94623713
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.86939882
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.74747282
27	P300_19829295_ChIP-Seq_ESCs_Human	1.71272873
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71204447
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70170711
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.67039783
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.65655527
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.65162141
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.61371729
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58597814
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57219261
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55942216
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.55934136
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53523703
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.51522701
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50176884
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.44148697
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41100223
43	* AR_20517297_ChIP-Seq_VCAP_Human	1.38789052
44	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.36295654
45	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33842710
46	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33842710
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33401420
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33401420
49	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.30927156
50	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29819662
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29055037
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27456463
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.24394306
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24394306
55	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.23812116
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23246657
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23149292
58	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.22920656
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22718938
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20953552
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18174250
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18019250
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16397653
64	NCOR_22424771_ChIP-Seq_293T_Human	1.14721134
65	AR_25329375_ChIP-Seq_VCAP_Human	1.14601917
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14465074
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10196312
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09667411
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08419941
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08267405
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08056499
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06505544
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06062386
74	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05586408
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05086575
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04386836
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.04237858
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03974621
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.03912395
80	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.02747319
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02710086
82	GATA3_26560356_Chip-Seq_TH2_Human	1.02449163
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02227897
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01761455
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01759852
86	STAT3_23295773_ChIP-Seq_U87_Human	1.01449000
87	TCF4_23295773_ChIP-Seq_U87_Human	1.01264167
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00312867
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98937074
90	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98740015
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97997845
92	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.97123674
93	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.96763260
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95963775
95	* MYC_19829295_ChIP-Seq_ESCs_Human	0.94352272
96	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94068098
97	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94068098
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93561748
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92903883
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92583239

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.11917154
2	MP0002102_abnormal_ear_morphology	3.07166049
3	MP0002837_dystrophic_cardiac_calcinosis	2.86182751
4	MP0000372_irregular_coat_pigmentation	2.73628809
5	MP0008877_abnormal_DNA_methylation	2.69517523
6	MP0003787_abnormal_imprinting	2.32055162
7	MP0006072_abnormal_retinal_apoptosis	2.24192968
8	MP0005646_abnormal_pituitary_gland	2.22454197
9	MP0002638_abnormal_pupillary_reflex	2.16007752
10	MP0002876_abnormal_thyroid_physiology	2.11668734
11	MP0005645_abnormal_hypothalamus_physiol	2.10042320
12	MP0002938_white_spotting	2.07600559
13	MP0005084_abnormal_gallbladder_morpholo	2.02768768
14	MP0005551_abnormal_eye_electrophysiolog	2.01063253
15	MP0008872_abnormal_physiological_respon	2.00808808
16	MP0002163_abnormal_gland_morphology	1.97466532
17	MP0006292_abnormal_olfactory_placode	1.91312086
18	MP0008058_abnormal_DNA_repair	1.82846773
19	MP0005253_abnormal_eye_physiology	1.82634994
20	MP0003136_yellow_coat_color	1.82317220
21	MP0003646_muscle_fatigue	1.76381199
22	MP0001968_abnormal_touch/_nociception	1.74810832
23	MP0001986_abnormal_taste_sensitivity	1.72780701
24	MP0004147_increased_porphyrin_level	1.64753151
25	MP0005075_abnormal_melanosome_morpholog	1.63970082
26	MP0005379_endocrine/exocrine_gland_phen	1.61886491
27	MP0000631_abnormal_neuroendocrine_gland	1.56773067
28	MP0004142_abnormal_muscle_tone	1.56513657
29	MP0005174_abnormal_tail_pigmentation	1.56424116
30	MP0001485_abnormal_pinna_reflex	1.48488849
31	MP0002277_abnormal_respiratory_mucosa	1.43387225
32	MP0002736_abnormal_nociception_after	1.38219193
33	MP0004043_abnormal_pH_regulation	1.33330878
34	MP0004133_heterotaxia	1.32196242
35	MP0001529_abnormal_vocalization	1.31822825
36	MP0003122_maternal_imprinting	1.29125701
37	MP0002653_abnormal_ependyma_morphology	1.28801746
38	MP0008995_early_reproductive_senescence	1.27895786
39	MP0002928_abnormal_bile_duct	1.26941605
40	MP0004885_abnormal_endolymph	1.23695569
41	MP0001984_abnormal_olfaction	1.23484398
42	MP0003121_genomic_imprinting	1.22204289
43	MP0000569_abnormal_digit_pigmentation	1.22127878
44	MP0001905_abnormal_dopamine_level	1.21924478
45	MP0000516_abnormal_urinary_system	1.21361346
46	MP0005367_renal/urinary_system_phenotyp	1.21361346
47	MP0003283_abnormal_digestive_organ	1.21307576
48	MP0008875_abnormal_xenobiotic_pharmacok	1.20473355
49	MP0002095_abnormal_skin_pigmentation	1.19056135
50	MP0006036_abnormal_mitochondrial_physio	1.18151527
51	MP0003806_abnormal_nucleotide_metabolis	1.15067850
52	MP0002693_abnormal_pancreas_physiology	1.14319856
53	MP0005389_reproductive_system_phenotype	1.13102733
54	MP0009046_muscle_twitch	1.12489161
55	MP0000383_abnormal_hair_follicle	1.10868355
56	MP0000427_abnormal_hair_cycle	1.09653271
57	MP0005220_abnormal_exocrine_pancreas	1.09464038
58	MP0003137_abnormal_impulse_conducting	1.09235036
59	MP0003011_delayed_dark_adaptation	1.07871098
60	MP0002234_abnormal_pharynx_morphology	1.07752801
61	MP0005083_abnormal_biliary_tract	1.07291735
62	MP0001764_abnormal_homeostasis	1.05807911
63	MP0002160_abnormal_reproductive_system	1.05491270
64	MP0002822_catalepsy	1.04590805
65	MP0009745_abnormal_behavioral_response	1.03969204
66	MP0005671_abnormal_response_to	1.02021449
67	MP0006276_abnormal_autonomic_nervous	1.01086598
68	MP0008789_abnormal_olfactory_epithelium	1.00786144
69	MP0004145_abnormal_muscle_electrophysio	0.99044808
70	MP0003786_premature_aging	0.95602407
71	MP0005332_abnormal_amino_acid	0.94564514
72	MP0001919_abnormal_reproductive_system	0.93269531
73	MP0002751_abnormal_autonomic_nervous	0.91294393
74	MP0000015_abnormal_ear_pigmentation	0.89836368
75	MP0002735_abnormal_chemical_nociception	0.89412309
76	MP0008775_abnormal_heart_ventricle	0.87067629
77	MP0003252_abnormal_bile_duct	0.85367202
78	MP0001929_abnormal_gametogenesis	0.84725116
79	MP0005377_hearing/vestibular/ear_phenot	0.84605151
80	MP0003878_abnormal_ear_physiology	0.84605151
81	MP0003718_maternal_effect	0.83816531
82	MP0001944_abnormal_pancreas_morphology	0.83762870
83	MP0005167_abnormal_blood-brain_barrier	0.83728128
84	MP0003186_abnormal_redox_activity	0.83690352
85	MP0002272_abnormal_nervous_system	0.83160946
86	MP0005410_abnormal_fertilization	0.82895876
87	MP0005636_abnormal_mineral_homeostasis	0.82289521
88	MP0002557_abnormal_social/conspecific_i	0.81602214
89	MP0004924_abnormal_behavior	0.77877430
90	MP0005386_behavior/neurological_phenoty	0.77877430
91	MP0010329_abnormal_lipoprotein_level	0.77658532
92	MP0001486_abnormal_startle_reflex	0.77138969
93	MP0003698_abnormal_male_reproductive	0.74866498
94	MP0005195_abnormal_posterior_eye	0.74751317
95	MP0000230_abnormal_systemic_arterial	0.74744917
96	MP0001324_abnormal_eye_pigmentation	0.74709376
97	MP0004215_abnormal_myocardial_fiber	0.74374533
98	MP0003724_increased_susceptibility_to	0.73367556
99	MP0002572_abnormal_emotion/affect_behav	0.72917562
100	MP0002909_abnormal_adrenal_gland	0.72421228

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.95682402
2	Pancreatic fibrosis (HP:0100732)	3.63292535
3	True hermaphroditism (HP:0010459)	3.39265573
4	Abnormality of midbrain morphology (HP:0002418)	3.34535647
5	Molar tooth sign on MRI (HP:0002419)	3.34535647
6	Mitochondrial inheritance (HP:0001427)	3.19162064
7	Acute necrotizing encephalopathy (HP:0006965)	3.13804693
8	Medial flaring of the eyebrow (HP:0010747)	3.09520623
9	Progressive macrocephaly (HP:0004481)	2.99018656
10	Hepatic necrosis (HP:0002605)	2.95674108
11	Nephronophthisis (HP:0000090)	2.94487340
12	Abnormality of the renal cortex (HP:0011035)	2.92269700
13	Increased CSF lactate (HP:0002490)	2.90708895
14	3-Methylglutaconic aciduria (HP:0003535)	2.88603128
15	Hepatocellular necrosis (HP:0001404)	2.87939965
16	Congenital stationary night blindness (HP:0007642)	2.83465403
17	Acute encephalopathy (HP:0006846)	2.80721454
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.80261186
19	Lipid accumulation in hepatocytes (HP:0006561)	2.71362494
20	Increased hepatocellular lipid droplets (HP:0006565)	2.70307210
21	Methylmalonic acidemia (HP:0002912)	2.65734550
22	Pendular nystagmus (HP:0012043)	2.60437618
23	Abnormality of the renal medulla (HP:0100957)	2.58338292
24	Hypothermia (HP:0002045)	2.55337167
25	Renal cortical cysts (HP:0000803)	2.51545488
26	Attenuation of retinal blood vessels (HP:0007843)	2.48471462
27	Methylmalonic aciduria (HP:0012120)	2.45356533
28	Thyroiditis (HP:0100646)	2.45309540
29	Congenital, generalized hypertrichosis (HP:0004540)	2.45308061
30	Cystic liver disease (HP:0006706)	2.40248723
31	Ketoacidosis (HP:0001993)	2.36784841
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.32327632
33	Renal Fanconi syndrome (HP:0001994)	2.30754074
34	Abolished electroretinogram (ERG) (HP:0000550)	2.30223665
35	Large for gestational age (HP:0001520)	2.25884545
36	Neoplasm of the adrenal cortex (HP:0100641)	2.23961176
37	Intestinal atresia (HP:0011100)	2.19220469
38	Ketosis (HP:0001946)	2.18167009
39	Decreased central vision (HP:0007663)	2.15717117
40	Hyperglycinemia (HP:0002154)	2.15163495
41	Congenital primary aphakia (HP:0007707)	2.13454801
42	Colon cancer (HP:0003003)	2.13011182
43	Type II lissencephaly (HP:0007260)	2.12529797
44	Optic disc pallor (HP:0000543)	2.11511704
45	Gait imbalance (HP:0002141)	2.09635422
46	Decreased circulating renin level (HP:0003351)	2.05755908
47	Furrowed tongue (HP:0000221)	2.04787713
48	Polydipsia (HP:0001959)	2.04759243
49	Abnormal drinking behavior (HP:0030082)	2.04759243
50	Sclerocornea (HP:0000647)	2.01785280
51	Severe combined immunodeficiency (HP:0004430)	1.99555878
52	Nephrogenic diabetes insipidus (HP:0009806)	1.98394962
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.96232086
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.96086218
55	Exertional dyspnea (HP:0002875)	1.95316925
56	Neoplasm of the adrenal gland (HP:0100631)	1.95282472
57	Abnormal respiratory epithelium morphology (HP:0012253)	1.94535070
58	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94535070
59	Stomatitis (HP:0010280)	1.94227450
60	Lactic acidosis (HP:0003128)	1.93511175
61	Chronic hepatic failure (HP:0100626)	1.91800881
62	Hemiparesis (HP:0001269)	1.91376478
63	Increased serum lactate (HP:0002151)	1.90125282
64	Panhypogammaglobulinemia (HP:0003139)	1.88784442
65	Increased intramyocellular lipid droplets (HP:0012240)	1.88727027
66	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88137565
67	Anencephaly (HP:0002323)	1.86782698
68	Glycosuria (HP:0003076)	1.86234380
69	Abnormality of urine glucose concentration (HP:0011016)	1.86234380
70	Cerebral edema (HP:0002181)	1.83136575
71	Absent/shortened dynein arms (HP:0200106)	1.82960590
72	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82960590
73	Male pseudohermaphroditism (HP:0000037)	1.82092839
74	Hypomagnesemia (HP:0002917)	1.81809069
75	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.81728493
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.81728493
77	Absent thumb (HP:0009777)	1.81585323
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.80940182
79	Genital tract atresia (HP:0001827)	1.80316860
80	Congenital hepatic fibrosis (HP:0002612)	1.79645256
81	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.79279573
82	Hypoplasia of the fovea (HP:0007750)	1.79279573
83	Abnormality of the labia minora (HP:0012880)	1.78770016
84	Bile duct proliferation (HP:0001408)	1.75591751
85	Abnormal biliary tract physiology (HP:0012439)	1.75591751
86	Congenital sensorineural hearing impairment (HP:0008527)	1.75579966
87	Postaxial foot polydactyly (HP:0001830)	1.75255222
88	Abnormality of vitamin B metabolism (HP:0004340)	1.74259485
89	Abnormal ciliary motility (HP:0012262)	1.74181538
90	Lethargy (HP:0001254)	1.73938194
91	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73483582
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.71592035
93	Keratoconus (HP:0000563)	1.70501112
94	Increased corneal curvature (HP:0100692)	1.70501112
95	Abnormality of renal resorption (HP:0011038)	1.70143702
96	Tubular atrophy (HP:0000092)	1.69944803
97	Respiratory failure (HP:0002878)	1.68837812
98	Dicarboxylic aciduria (HP:0003215)	1.68520763
99	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.68520763
100	Vaginal atresia (HP:0000148)	1.68049610

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.64401146
2	WNK3	3.34788489
3	NUAK1	3.28411847
4	BMPR1B	2.91436962
5	MAP4K2	2.68457134
6	ZAK	2.49365597
7	ADRBK2	2.33312417
8	VRK2	2.25451258
9	TAOK3	2.22215425
10	GRK1	2.09845681
11	MAPK13	1.90889754
12	FGFR2	1.79466551
13	TLK1	1.71158775
14	TRIM28	1.70883247
15	ACVR1B	1.65269007
16	VRK1	1.60142291
17	BCKDK	1.60135952
18	PINK1	1.57476573
19	TNIK	1.56523877
20	TXK	1.52080822
21	INSRR	1.44149722
22	MST4	1.42555488
23	WNK4	1.26056454
24	PLK2	1.21050761
25	CASK	1.19633346
26	MAP3K4	1.19508847
27	EIF2AK3	1.16191239
28	OXSR1	1.14993091
29	TIE1	1.14660547
30	MUSK	1.12811846
31	ERBB3	1.11374856
32	PLK3	1.10196045
33	MAP2K6	1.09748700
34	PAK3	1.09004046
35	MAPKAPK3	1.05980953
36	STK16	1.05154414
37	MKNK2	1.04927132
38	DAPK2	1.03296297
39	TEC	0.99079427
40	DYRK2	0.95947442
41	TNK2	0.94268403
42	PHKG2	0.90442076
43	PHKG1	0.90442076
44	CSNK1G3	0.89125936
45	OBSCN	0.87251680
46	KIT	0.86378575
47	PASK	0.85302464
48	CCNB1	0.83000173
49	PNCK	0.82677955
50	PTK2B	0.82422279
51	STK39	0.80857021
52	WEE1	0.80809506
53	CSNK1G1	0.79448000
54	CSNK1G2	0.79360955
55	FER	0.76948237
56	CAMKK2	0.76065967
57	IKBKB	0.74796997
58	ADRBK1	0.70931929
59	TGFBR1	0.70780428
60	MAPK15	0.70775131
61	MAP4K1	0.70646069
62	PRKCE	0.67379649
63	BRSK2	0.66628471
64	IRAK4	0.65378393
65	MKNK1	0.64662707
66	TAF1	0.64260214
67	BCR	0.64143019
68	NLK	0.63039285
69	CSNK1A1L	0.61684848
70	EPHA3	0.61177059
71	PLK4	0.60113504
72	PRKCQ	0.58589633
73	PRKCG	0.58484751
74	EIF2AK1	0.57716853
75	GRK6	0.56711364
76	ITK	0.56119197
77	SYK	0.53774187
78	RPS6KA5	0.53061130
79	PRKCI	0.51671066
80	IRAK1	0.51269572
81	ATR	0.50742899
82	STK38L	0.50677285
83	MAPKAPK5	0.50116232
84	KDR	0.48563278
85	MAP2K7	0.47936032
86	MARK3	0.46875738
87	NME1	0.44901755
88	FES	0.44045794
89	LYN	0.41922614
90	FLT3	0.40069575
91	BMPR2	0.39726987
92	BTK	0.39216664
93	EIF2AK2	0.38611373
94	BUB1	0.37148011
95	PRKACA	0.36887653
96	PLK1	0.34535282
97	NEK2	0.34325321
98	PKN1	0.32831100
99	CSNK1A1	0.32802762
100	IKBKE	0.32268731

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19814948
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.01952367
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.84999971
4	Parkinsons disease_Homo sapiens_hsa05012	2.59941660
5	Protein export_Homo sapiens_hsa03060	2.58680805
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.48608844
7	Homologous recombination_Homo sapiens_hsa03440	2.34941374
8	Butanoate metabolism_Homo sapiens_hsa00650	2.29845996
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16980484
10	Phototransduction_Homo sapiens_hsa04744	2.09111252
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08569757
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.03848381
13	Proteasome_Homo sapiens_hsa03050	2.01378021
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92967761
15	RNA polymerase_Homo sapiens_hsa03020	1.80415320
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79470238
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.72258492
18	Propanoate metabolism_Homo sapiens_hsa00640	1.66548717
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63109051
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.56986691
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56540026
22	Alzheimers disease_Homo sapiens_hsa05010	1.54657917
23	Peroxisome_Homo sapiens_hsa04146	1.51656480
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.51529155
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.49770477
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.49442228
27	Huntingtons disease_Homo sapiens_hsa05016	1.47209770
28	RNA degradation_Homo sapiens_hsa03018	1.46611446
29	Basal transcription factors_Homo sapiens_hsa03022	1.45511650
30	Fatty acid elongation_Homo sapiens_hsa00062	1.44876888
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43554151
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42537494
33	Regulation of autophagy_Homo sapiens_hsa04140	1.29566550
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25521476
35	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.21729662
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.19378558
37	Mismatch repair_Homo sapiens_hsa03430	1.18818174
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17476697
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.17392803
40	One carbon pool by folate_Homo sapiens_hsa00670	1.16034017
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14634815
42	Caffeine metabolism_Homo sapiens_hsa00232	1.13704436
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.13135509
44	Ribosome_Homo sapiens_hsa03010	1.12515773
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.08546810
46	Ether lipid metabolism_Homo sapiens_hsa00565	1.05396629
47	Asthma_Homo sapiens_hsa05310	1.05008247
48	Graft-versus-host disease_Homo sapiens_hsa05332	1.04257813
49	Base excision repair_Homo sapiens_hsa03410	1.01480549
50	Purine metabolism_Homo sapiens_hsa00230	1.01409790
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95949962
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95944493
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93145938
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92946325
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92837907
56	Allograft rejection_Homo sapiens_hsa05330	0.90555280
57	Sulfur metabolism_Homo sapiens_hsa00920	0.89714177
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.88813786
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.88202315
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85891722
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.83403730
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80235403
63	Metabolic pathways_Homo sapiens_hsa01100	0.76441737
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75452569
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.73776584
66	Olfactory transduction_Homo sapiens_hsa04740	0.73148018
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69205782
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68789505
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68384615
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.67693523
71	ABC transporters_Homo sapiens_hsa02010	0.66972813
72	Retinol metabolism_Homo sapiens_hsa00830	0.65106822
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63984124
74	Glutathione metabolism_Homo sapiens_hsa00480	0.63588349
75	Nicotine addiction_Homo sapiens_hsa05033	0.62772205
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.62165778
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60387798
78	Insulin secretion_Homo sapiens_hsa04911	0.58364650
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57641540
80	Taste transduction_Homo sapiens_hsa04742	0.57587971
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.56471815
82	Fatty acid degradation_Homo sapiens_hsa00071	0.56327643
83	Folate biosynthesis_Homo sapiens_hsa00790	0.56060711
84	DNA replication_Homo sapiens_hsa03030	0.55848509
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54042338
86	Morphine addiction_Homo sapiens_hsa05032	0.53785797
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53406058
88	Antigen processing and presentation_Homo sapiens_hsa04612	0.52005770
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47055378
90	Serotonergic synapse_Homo sapiens_hsa04726	0.45245843
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43037636
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42375031
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39848955
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.38572304
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37896014
96	GABAergic synapse_Homo sapiens_hsa04727	0.35132563
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.32466471
98	p53 signaling pathway_Homo sapiens_hsa04115	0.31160528
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31149608
100	RNA transport_Homo sapiens_hsa03013	0.28648207

C2ORF68

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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