C2ORF68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.92959857
2protein complex biogenesis (GO:0070271)4.19155225
3respiratory chain complex IV assembly (GO:0008535)4.17227275
4platelet dense granule organization (GO:0060155)4.16892248
5cytochrome complex assembly (GO:0017004)3.90825236
6mitochondrial respiratory chain complex assembly (GO:0033108)3.76534865
7behavioral response to nicotine (GO:0035095)3.75834419
8water-soluble vitamin biosynthetic process (GO:0042364)3.75230810
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67484030
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.67484030
11NADH dehydrogenase complex assembly (GO:0010257)3.67484030
12regulation of hexokinase activity (GO:1903299)3.57368117
13regulation of glucokinase activity (GO:0033131)3.57368117
14preassembly of GPI anchor in ER membrane (GO:0016254)3.54626099
15mannosylation (GO:0097502)3.52669000
16DNA double-strand break processing (GO:0000729)3.51508525
17axoneme assembly (GO:0035082)3.43914689
18L-fucose metabolic process (GO:0042354)3.40139809
19L-fucose catabolic process (GO:0042355)3.40139809
20fucose catabolic process (GO:0019317)3.40139809
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34124208
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33993063
23protein neddylation (GO:0045116)3.32197176
24inositol phosphate catabolic process (GO:0071545)3.20205565
25cellular ketone body metabolic process (GO:0046950)3.20142092
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19808407
27ATP synthesis coupled proton transport (GO:0015986)3.19808407
28epithelial cilium movement (GO:0003351)3.19060247
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08847774
30centriole replication (GO:0007099)3.08301711
31regulation of cilium movement (GO:0003352)3.06180398
32ketone body metabolic process (GO:1902224)3.05449182
33negative regulation of telomere maintenance (GO:0032205)3.03619075
34protein K6-linked ubiquitination (GO:0085020)3.01205938
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98695911
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95909500
37peptidyl-histidine modification (GO:0018202)2.91336242
38replication fork processing (GO:0031297)2.91091135
39establishment of protein localization to mitochondrial membrane (GO:0090151)2.90463440
40indole-containing compound catabolic process (GO:0042436)2.86835270
41indolalkylamine catabolic process (GO:0046218)2.86835270
42tryptophan catabolic process (GO:0006569)2.86835270
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85096622
44indolalkylamine metabolic process (GO:0006586)2.82138633
45response to pheromone (GO:0019236)2.82119593
46protein polyglutamylation (GO:0018095)2.82096794
47adenosine metabolic process (GO:0046085)2.82086947
48phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78633915
49inositol phosphate dephosphorylation (GO:0046855)2.78633915
50GPI anchor metabolic process (GO:0006505)2.76254401
51electron transport chain (GO:0022900)2.72754079
52ubiquinone biosynthetic process (GO:0006744)2.71450917
53protein localization to cilium (GO:0061512)2.70862450
54cytidine deamination (GO:0009972)2.68003567
55cytidine metabolic process (GO:0046087)2.68003567
56cytidine catabolic process (GO:0006216)2.68003567
57respiratory electron transport chain (GO:0022904)2.67783743
58sulfation (GO:0051923)2.66768652
59neuron fate determination (GO:0048664)2.63632471
60adaptation of signaling pathway (GO:0023058)2.62841241
61dopamine transport (GO:0015872)2.61112141
62C-terminal protein lipidation (GO:0006501)2.60996152
63aggressive behavior (GO:0002118)2.60555599
64anterograde synaptic vesicle transport (GO:0048490)2.59167457
65positive regulation of prostaglandin secretion (GO:0032308)2.58901168
66cilium morphogenesis (GO:0060271)2.56032330
67intraciliary transport (GO:0042073)2.55585954
68kynurenine metabolic process (GO:0070189)2.54437867
69prostate gland growth (GO:0060736)2.53699945
70nonmotile primary cilium assembly (GO:0035058)2.52397220
71polyol catabolic process (GO:0046174)2.51539960
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50568521
73nephron epithelium morphogenesis (GO:0072088)2.50204629
74nephron tubule morphogenesis (GO:0072078)2.50204629
75piRNA metabolic process (GO:0034587)2.48684600
76protein-cofactor linkage (GO:0018065)2.48568913
77cilium movement (GO:0003341)2.48493236
78somite development (GO:0061053)2.48405814
79ubiquinone metabolic process (GO:0006743)2.47996038
80branched-chain amino acid catabolic process (GO:0009083)2.47283637
81dentate gyrus development (GO:0021542)2.46054606
82S-adenosylmethionine metabolic process (GO:0046500)2.45463796
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45181562
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45181562
85signal peptide processing (GO:0006465)2.45143070
86C-terminal protein amino acid modification (GO:0018410)2.44065913
87prenylation (GO:0097354)2.43687734
88protein prenylation (GO:0018342)2.43687734
89tryptophan metabolic process (GO:0006568)2.43581836
90base-excision repair, AP site formation (GO:0006285)2.43201217
91kidney morphogenesis (GO:0060993)2.41827860
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.40834182
93recombinational repair (GO:0000725)2.40757898
94double-strand break repair via homologous recombination (GO:0000724)2.40070511
95GPI anchor biosynthetic process (GO:0006506)2.39380351
96photoreceptor cell maintenance (GO:0045494)2.37898941
97regulation of meiosis I (GO:0060631)2.37186827
98regulation of B cell apoptotic process (GO:0002902)2.34779539
99cilium organization (GO:0044782)2.33573474
100DNA demethylation (GO:0080111)2.31549659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.73430455
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37834937
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91413979
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.88414701
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83912348
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.75821827
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71962232
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61888523
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56485477
10VDR_22108803_ChIP-Seq_LS180_Human2.52184812
11IGF1R_20145208_ChIP-Seq_DFB_Human2.48645429
12GBX2_23144817_ChIP-Seq_PC3_Human2.36073820
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27160735
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26623106
15EWS_26573619_Chip-Seq_HEK293_Human2.23879515
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.11993093
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07560877
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06746672
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03845834
20VDR_23849224_ChIP-Seq_CD4+_Human1.97901729
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96570117
22FUS_26573619_Chip-Seq_HEK293_Human1.95333846
23ELK1_19687146_ChIP-ChIP_HELA_Human1.95062515
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94623713
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.86939882
26MYC_18940864_ChIP-ChIP_HL60_Human1.74747282
27P300_19829295_ChIP-Seq_ESCs_Human1.71272873
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71204447
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70170711
30TAF15_26573619_Chip-Seq_HEK293_Human1.67039783
31TP53_22573176_ChIP-Seq_HFKS_Human1.65655527
32ER_23166858_ChIP-Seq_MCF-7_Human1.65162141
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.61371729
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.58597814
35IRF1_19129219_ChIP-ChIP_H3396_Human1.57219261
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55942216
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55934136
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.53523703
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51522701
40FOXP3_21729870_ChIP-Seq_TREG_Human1.50176884
41BCAT_22108803_ChIP-Seq_LS180_Human1.44148697
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41100223
43* AR_20517297_ChIP-Seq_VCAP_Human1.38789052
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.36295654
45* FOXA1_25329375_ChIP-Seq_VCAP_Human1.33842710
46* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33842710
47SOX2_19829295_ChIP-Seq_ESCs_Human1.33401420
48NANOG_19829295_ChIP-Seq_ESCs_Human1.33401420
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30927156
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29819662
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29055037
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.27456463
53CBP_20019798_ChIP-Seq_JUKART_Human1.24394306
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24394306
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23812116
56HTT_18923047_ChIP-ChIP_STHdh_Human1.23246657
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.23149292
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22920656
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22718938
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.20953552
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18174250
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18019250
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16397653
64NCOR_22424771_ChIP-Seq_293T_Human1.14721134
65AR_25329375_ChIP-Seq_VCAP_Human1.14601917
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14465074
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10196312
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09667411
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08419941
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08267405
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08056499
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06505544
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06062386
74SMAD4_21799915_ChIP-Seq_A2780_Human1.05586408
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.05086575
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.04386836
77TCF4_22108803_ChIP-Seq_LS180_Human1.04237858
78HOXB7_26014856_ChIP-Seq_BT474_Human1.03974621
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03912395
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02747319
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02710086
82GATA3_26560356_Chip-Seq_TH2_Human1.02449163
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02227897
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.01761455
85P53_22387025_ChIP-Seq_ESCs_Mouse1.01759852
86STAT3_23295773_ChIP-Seq_U87_Human1.01449000
87TCF4_23295773_ChIP-Seq_U87_Human1.01264167
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00312867
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98937074
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98740015
91NANOG_20526341_ChIP-Seq_ESCs_Human0.97997845
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97123674
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96763260
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95963775
95* MYC_19829295_ChIP-Seq_ESCs_Human0.94352272
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94068098
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94068098
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93561748
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92903883
100RNF2_27304074_Chip-Seq_NSC_Mouse0.92583239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.11917154
2MP0002102_abnormal_ear_morphology3.07166049
3MP0002837_dystrophic_cardiac_calcinosis2.86182751
4MP0000372_irregular_coat_pigmentation2.73628809
5MP0008877_abnormal_DNA_methylation2.69517523
6MP0003787_abnormal_imprinting2.32055162
7MP0006072_abnormal_retinal_apoptosis2.24192968
8MP0005646_abnormal_pituitary_gland2.22454197
9MP0002638_abnormal_pupillary_reflex2.16007752
10MP0002876_abnormal_thyroid_physiology2.11668734
11MP0005645_abnormal_hypothalamus_physiol2.10042320
12MP0002938_white_spotting2.07600559
13MP0005084_abnormal_gallbladder_morpholo2.02768768
14MP0005551_abnormal_eye_electrophysiolog2.01063253
15MP0008872_abnormal_physiological_respon2.00808808
16MP0002163_abnormal_gland_morphology1.97466532
17MP0006292_abnormal_olfactory_placode1.91312086
18MP0008058_abnormal_DNA_repair1.82846773
19MP0005253_abnormal_eye_physiology1.82634994
20MP0003136_yellow_coat_color1.82317220
21MP0003646_muscle_fatigue1.76381199
22MP0001968_abnormal_touch/_nociception1.74810832
23MP0001986_abnormal_taste_sensitivity1.72780701
24MP0004147_increased_porphyrin_level1.64753151
25MP0005075_abnormal_melanosome_morpholog1.63970082
26MP0005379_endocrine/exocrine_gland_phen1.61886491
27MP0000631_abnormal_neuroendocrine_gland1.56773067
28MP0004142_abnormal_muscle_tone1.56513657
29MP0005174_abnormal_tail_pigmentation1.56424116
30MP0001485_abnormal_pinna_reflex1.48488849
31MP0002277_abnormal_respiratory_mucosa1.43387225
32MP0002736_abnormal_nociception_after1.38219193
33MP0004043_abnormal_pH_regulation1.33330878
34MP0004133_heterotaxia1.32196242
35MP0001529_abnormal_vocalization1.31822825
36MP0003122_maternal_imprinting1.29125701
37MP0002653_abnormal_ependyma_morphology1.28801746
38MP0008995_early_reproductive_senescence1.27895786
39MP0002928_abnormal_bile_duct1.26941605
40MP0004885_abnormal_endolymph1.23695569
41MP0001984_abnormal_olfaction1.23484398
42MP0003121_genomic_imprinting1.22204289
43MP0000569_abnormal_digit_pigmentation1.22127878
44MP0001905_abnormal_dopamine_level1.21924478
45MP0005367_renal/urinary_system_phenotyp1.21361346
46MP0000516_abnormal_urinary_system1.21361346
47MP0003283_abnormal_digestive_organ1.21307576
48MP0008875_abnormal_xenobiotic_pharmacok1.20473355
49MP0002095_abnormal_skin_pigmentation1.19056135
50MP0006036_abnormal_mitochondrial_physio1.18151527
51MP0003806_abnormal_nucleotide_metabolis1.15067850
52MP0002693_abnormal_pancreas_physiology1.14319856
53MP0005389_reproductive_system_phenotype1.13102733
54MP0009046_muscle_twitch1.12489161
55MP0000383_abnormal_hair_follicle1.10868355
56MP0000427_abnormal_hair_cycle1.09653271
57MP0005220_abnormal_exocrine_pancreas1.09464038
58MP0003137_abnormal_impulse_conducting1.09235036
59MP0003011_delayed_dark_adaptation1.07871098
60MP0002234_abnormal_pharynx_morphology1.07752801
61MP0005083_abnormal_biliary_tract1.07291735
62MP0001764_abnormal_homeostasis1.05807911
63MP0002160_abnormal_reproductive_system1.05491270
64MP0002822_catalepsy1.04590805
65MP0009745_abnormal_behavioral_response1.03969204
66MP0005671_abnormal_response_to1.02021449
67MP0006276_abnormal_autonomic_nervous1.01086598
68MP0008789_abnormal_olfactory_epithelium1.00786144
69MP0004145_abnormal_muscle_electrophysio0.99044808
70MP0003786_premature_aging0.95602407
71MP0005332_abnormal_amino_acid0.94564514
72MP0001919_abnormal_reproductive_system0.93269531
73MP0002751_abnormal_autonomic_nervous0.91294393
74MP0000015_abnormal_ear_pigmentation0.89836368
75MP0002735_abnormal_chemical_nociception0.89412309
76MP0008775_abnormal_heart_ventricle0.87067629
77MP0003252_abnormal_bile_duct0.85367202
78MP0001929_abnormal_gametogenesis0.84725116
79MP0003878_abnormal_ear_physiology0.84605151
80MP0005377_hearing/vestibular/ear_phenot0.84605151
81MP0003718_maternal_effect0.83816531
82MP0001944_abnormal_pancreas_morphology0.83762870
83MP0005167_abnormal_blood-brain_barrier0.83728128
84MP0003186_abnormal_redox_activity0.83690352
85MP0002272_abnormal_nervous_system0.83160946
86MP0005410_abnormal_fertilization0.82895876
87MP0005636_abnormal_mineral_homeostasis0.82289521
88MP0002557_abnormal_social/conspecific_i0.81602214
89MP0004924_abnormal_behavior0.77877430
90MP0005386_behavior/neurological_phenoty0.77877430
91MP0010329_abnormal_lipoprotein_level0.77658532
92MP0001486_abnormal_startle_reflex0.77138969
93MP0003698_abnormal_male_reproductive0.74866498
94MP0005195_abnormal_posterior_eye0.74751317
95MP0000230_abnormal_systemic_arterial0.74744917
96MP0001324_abnormal_eye_pigmentation0.74709376
97MP0004215_abnormal_myocardial_fiber0.74374533
98MP0003724_increased_susceptibility_to0.73367556
99MP0002572_abnormal_emotion/affect_behav0.72917562
100MP0002909_abnormal_adrenal_gland0.72421228

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.95682402
2Pancreatic fibrosis (HP:0100732)3.63292535
3True hermaphroditism (HP:0010459)3.39265573
4Abnormality of midbrain morphology (HP:0002418)3.34535647
5Molar tooth sign on MRI (HP:0002419)3.34535647
6Mitochondrial inheritance (HP:0001427)3.19162064
7Acute necrotizing encephalopathy (HP:0006965)3.13804693
8Medial flaring of the eyebrow (HP:0010747)3.09520623
9Progressive macrocephaly (HP:0004481)2.99018656
10Hepatic necrosis (HP:0002605)2.95674108
11Nephronophthisis (HP:0000090)2.94487340
12Abnormality of the renal cortex (HP:0011035)2.92269700
13Increased CSF lactate (HP:0002490)2.90708895
143-Methylglutaconic aciduria (HP:0003535)2.88603128
15Hepatocellular necrosis (HP:0001404)2.87939965
16Congenital stationary night blindness (HP:0007642)2.83465403
17Acute encephalopathy (HP:0006846)2.80721454
18Abnormal mitochondria in muscle tissue (HP:0008316)2.80261186
19Lipid accumulation in hepatocytes (HP:0006561)2.71362494
20Increased hepatocellular lipid droplets (HP:0006565)2.70307210
21Methylmalonic acidemia (HP:0002912)2.65734550
22Pendular nystagmus (HP:0012043)2.60437618
23Abnormality of the renal medulla (HP:0100957)2.58338292
24Hypothermia (HP:0002045)2.55337167
25Renal cortical cysts (HP:0000803)2.51545488
26Attenuation of retinal blood vessels (HP:0007843)2.48471462
27Methylmalonic aciduria (HP:0012120)2.45356533
28Thyroiditis (HP:0100646)2.45309540
29Congenital, generalized hypertrichosis (HP:0004540)2.45308061
30Cystic liver disease (HP:0006706)2.40248723
31Ketoacidosis (HP:0001993)2.36784841
32Abnormal rod and cone electroretinograms (HP:0008323)2.32327632
33Renal Fanconi syndrome (HP:0001994)2.30754074
34Abolished electroretinogram (ERG) (HP:0000550)2.30223665
35Large for gestational age (HP:0001520)2.25884545
36Neoplasm of the adrenal cortex (HP:0100641)2.23961176
37Intestinal atresia (HP:0011100)2.19220469
38Ketosis (HP:0001946)2.18167009
39Decreased central vision (HP:0007663)2.15717117
40Hyperglycinemia (HP:0002154)2.15163495
41Congenital primary aphakia (HP:0007707)2.13454801
42Colon cancer (HP:0003003)2.13011182
43Type II lissencephaly (HP:0007260)2.12529797
44Optic disc pallor (HP:0000543)2.11511704
45Gait imbalance (HP:0002141)2.09635422
46Decreased circulating renin level (HP:0003351)2.05755908
47Furrowed tongue (HP:0000221)2.04787713
48Abnormal drinking behavior (HP:0030082)2.04759243
49Polydipsia (HP:0001959)2.04759243
50Sclerocornea (HP:0000647)2.01785280
51Severe combined immunodeficiency (HP:0004430)1.99555878
52Nephrogenic diabetes insipidus (HP:0009806)1.98394962
53Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96232086
54Aplasia/Hypoplasia of the tongue (HP:0010295)1.96086218
55Exertional dyspnea (HP:0002875)1.95316925
56Neoplasm of the adrenal gland (HP:0100631)1.95282472
57Abnormal respiratory epithelium morphology (HP:0012253)1.94535070
58Abnormal respiratory motile cilium morphology (HP:0005938)1.94535070
59Stomatitis (HP:0010280)1.94227450
60Lactic acidosis (HP:0003128)1.93511175
61Chronic hepatic failure (HP:0100626)1.91800881
62Hemiparesis (HP:0001269)1.91376478
63Increased serum lactate (HP:0002151)1.90125282
64Panhypogammaglobulinemia (HP:0003139)1.88784442
65Increased intramyocellular lipid droplets (HP:0012240)1.88727027
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88137565
67Anencephaly (HP:0002323)1.86782698
68Glycosuria (HP:0003076)1.86234380
69Abnormality of urine glucose concentration (HP:0011016)1.86234380
70Cerebral edema (HP:0002181)1.83136575
71Absent/shortened dynein arms (HP:0200106)1.82960590
72Dynein arm defect of respiratory motile cilia (HP:0012255)1.82960590
73Male pseudohermaphroditism (HP:0000037)1.82092839
74Hypomagnesemia (HP:0002917)1.81809069
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81728493
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81728493
77Absent thumb (HP:0009777)1.81585323
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80940182
79Genital tract atresia (HP:0001827)1.80316860
80Congenital hepatic fibrosis (HP:0002612)1.79645256
81Hypoplasia of the fovea (HP:0007750)1.79279573
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.79279573
83Abnormality of the labia minora (HP:0012880)1.78770016
84Bile duct proliferation (HP:0001408)1.75591751
85Abnormal biliary tract physiology (HP:0012439)1.75591751
86Congenital sensorineural hearing impairment (HP:0008527)1.75579966
87Postaxial foot polydactyly (HP:0001830)1.75255222
88Abnormality of vitamin B metabolism (HP:0004340)1.74259485
89Abnormal ciliary motility (HP:0012262)1.74181538
90Lethargy (HP:0001254)1.73938194
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.73483582
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71592035
93Increased corneal curvature (HP:0100692)1.70501112
94Keratoconus (HP:0000563)1.70501112
95Abnormality of renal resorption (HP:0011038)1.70143702
96Tubular atrophy (HP:0000092)1.69944803
97Respiratory failure (HP:0002878)1.68837812
98Dicarboxylic aciduria (HP:0003215)1.68520763
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68520763
100Vaginal atresia (HP:0000148)1.68049610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.64401146
2WNK33.34788489
3NUAK13.28411847
4BMPR1B2.91436962
5MAP4K22.68457134
6ZAK2.49365597
7ADRBK22.33312417
8VRK22.25451258
9TAOK32.22215425
10GRK12.09845681
11MAPK131.90889754
12FGFR21.79466551
13TLK11.71158775
14TRIM281.70883247
15ACVR1B1.65269007
16VRK11.60142291
17BCKDK1.60135952
18PINK11.57476573
19TNIK1.56523877
20TXK1.52080822
21INSRR1.44149722
22MST41.42555488
23WNK41.26056454
24PLK21.21050761
25CASK1.19633346
26MAP3K41.19508847
27EIF2AK31.16191239
28OXSR11.14993091
29TIE11.14660547
30MUSK1.12811846
31ERBB31.11374856
32PLK31.10196045
33MAP2K61.09748700
34PAK31.09004046
35MAPKAPK31.05980953
36STK161.05154414
37MKNK21.04927132
38DAPK21.03296297
39TEC0.99079427
40DYRK20.95947442
41TNK20.94268403
42PHKG20.90442076
43PHKG10.90442076
44CSNK1G30.89125936
45OBSCN0.87251680
46KIT0.86378575
47PASK0.85302464
48CCNB10.83000173
49PNCK0.82677955
50PTK2B0.82422279
51STK390.80857021
52WEE10.80809506
53CSNK1G10.79448000
54CSNK1G20.79360955
55FER0.76948237
56CAMKK20.76065967
57IKBKB0.74796997
58ADRBK10.70931929
59TGFBR10.70780428
60MAPK150.70775131
61MAP4K10.70646069
62PRKCE0.67379649
63BRSK20.66628471
64IRAK40.65378393
65MKNK10.64662707
66TAF10.64260214
67BCR0.64143019
68NLK0.63039285
69CSNK1A1L0.61684848
70EPHA30.61177059
71PLK40.60113504
72PRKCQ0.58589633
73PRKCG0.58484751
74EIF2AK10.57716853
75GRK60.56711364
76ITK0.56119197
77SYK0.53774187
78RPS6KA50.53061130
79PRKCI0.51671066
80IRAK10.51269572
81ATR0.50742899
82STK38L0.50677285
83MAPKAPK50.50116232
84KDR0.48563278
85MAP2K70.47936032
86MARK30.46875738
87NME10.44901755
88FES0.44045794
89LYN0.41922614
90FLT30.40069575
91BMPR20.39726987
92BTK0.39216664
93EIF2AK20.38611373
94BUB10.37148011
95PRKACA0.36887653
96PLK10.34535282
97NEK20.34325321
98PKN10.32831100
99CSNK1A10.32802762
100IKBKE0.32268731

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.19814948
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.01952367
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84999971
4Parkinsons disease_Homo sapiens_hsa050122.59941660
5Protein export_Homo sapiens_hsa030602.58680805
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48608844
7Homologous recombination_Homo sapiens_hsa034402.34941374
8Butanoate metabolism_Homo sapiens_hsa006502.29845996
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16980484
10Phototransduction_Homo sapiens_hsa047442.09111252
11Fanconi anemia pathway_Homo sapiens_hsa034602.08569757
12Nitrogen metabolism_Homo sapiens_hsa009102.03848381
13Proteasome_Homo sapiens_hsa030502.01378021
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92967761
15RNA polymerase_Homo sapiens_hsa030201.80415320
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79470238
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72258492
18Propanoate metabolism_Homo sapiens_hsa006401.66548717
19Linoleic acid metabolism_Homo sapiens_hsa005911.63109051
20Non-homologous end-joining_Homo sapiens_hsa034501.56986691
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56540026
22Alzheimers disease_Homo sapiens_hsa050101.54657917
23Peroxisome_Homo sapiens_hsa041461.51656480
24Primary immunodeficiency_Homo sapiens_hsa053401.51529155
25Type I diabetes mellitus_Homo sapiens_hsa049401.49770477
26Tryptophan metabolism_Homo sapiens_hsa003801.49442228
27Huntingtons disease_Homo sapiens_hsa050161.47209770
28RNA degradation_Homo sapiens_hsa030181.46611446
29Basal transcription factors_Homo sapiens_hsa030221.45511650
30Fatty acid elongation_Homo sapiens_hsa000621.44876888
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43554151
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42537494
33Regulation of autophagy_Homo sapiens_hsa041401.29566550
34Collecting duct acid secretion_Homo sapiens_hsa049661.25521476
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21729662
36Selenocompound metabolism_Homo sapiens_hsa004501.19378558
37Mismatch repair_Homo sapiens_hsa034301.18818174
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17476697
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17392803
40One carbon pool by folate_Homo sapiens_hsa006701.16034017
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14634815
42Caffeine metabolism_Homo sapiens_hsa002321.13704436
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13135509
44Ribosome_Homo sapiens_hsa030101.12515773
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.08546810
46Ether lipid metabolism_Homo sapiens_hsa005651.05396629
47Asthma_Homo sapiens_hsa053101.05008247
48Graft-versus-host disease_Homo sapiens_hsa053321.04257813
49Base excision repair_Homo sapiens_hsa034101.01480549
50Purine metabolism_Homo sapiens_hsa002301.01409790
51Chemical carcinogenesis_Homo sapiens_hsa052040.95949962
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.95944493
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93145938
54Cardiac muscle contraction_Homo sapiens_hsa042600.92946325
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92837907
56Allograft rejection_Homo sapiens_hsa053300.90555280
57Sulfur metabolism_Homo sapiens_hsa009200.89714177
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88813786
59Autoimmune thyroid disease_Homo sapiens_hsa053200.88202315
60Arachidonic acid metabolism_Homo sapiens_hsa005900.85891722
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83403730
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.80235403
63Metabolic pathways_Homo sapiens_hsa011000.76441737
64Pyrimidine metabolism_Homo sapiens_hsa002400.75452569
65Nucleotide excision repair_Homo sapiens_hsa034200.73776584
66Olfactory transduction_Homo sapiens_hsa047400.73148018
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69205782
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68789505
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68384615
70Steroid biosynthesis_Homo sapiens_hsa001000.67693523
71ABC transporters_Homo sapiens_hsa020100.66972813
72Retinol metabolism_Homo sapiens_hsa008300.65106822
73Glycerolipid metabolism_Homo sapiens_hsa005610.63984124
74Glutathione metabolism_Homo sapiens_hsa004800.63588349
75Nicotine addiction_Homo sapiens_hsa050330.62772205
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62165778
77beta-Alanine metabolism_Homo sapiens_hsa004100.60387798
78Insulin secretion_Homo sapiens_hsa049110.58364650
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57641540
80Taste transduction_Homo sapiens_hsa047420.57587971
81Fatty acid metabolism_Homo sapiens_hsa012120.56471815
82Fatty acid degradation_Homo sapiens_hsa000710.56327643
83Folate biosynthesis_Homo sapiens_hsa007900.56060711
84DNA replication_Homo sapiens_hsa030300.55848509
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54042338
86Morphine addiction_Homo sapiens_hsa050320.53785797
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53406058
88Antigen processing and presentation_Homo sapiens_hsa046120.52005770
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47055378
90Serotonergic synapse_Homo sapiens_hsa047260.45245843
91Rheumatoid arthritis_Homo sapiens_hsa053230.43037636
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42375031
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.39848955
94Fat digestion and absorption_Homo sapiens_hsa049750.38572304
95Ovarian steroidogenesis_Homo sapiens_hsa049130.37896014
96GABAergic synapse_Homo sapiens_hsa047270.35132563
97Hematopoietic cell lineage_Homo sapiens_hsa046400.32466471
98p53 signaling pathway_Homo sapiens_hsa041150.31160528
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31149608
100RNA transport_Homo sapiens_hsa030130.28648207

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