ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	7.52570594
2	response to pheromone (GO:0019236)	7.05662685
3	motile cilium assembly (GO:0044458)	6.53312443
4	cilium movement (GO:0003341)	5.85144716
5	cobalamin metabolic process (GO:0009235)	5.84105257
6	cilium or flagellum-dependent cell motility (GO:0001539)	5.48254243
7	regulation of cilium movement (GO:0003352)	5.46584440
8	axoneme assembly (GO:0035082)	5.13455752
9	epithelial cilium movement (GO:0003351)	5.12591508
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.93720553
11	sperm motility (GO:0030317)	4.55074111
12	long term synaptic depression (GO:0060292)	4.53399230
13	protein localization to Golgi apparatus (GO:0034067)	4.45217801
14	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.14880567
15	regulation of microtubule-based movement (GO:0060632)	4.14396439
16	synapsis (GO:0007129)	4.13027321
17	platelet dense granule organization (GO:0060155)	4.10511611
18	protein targeting to Golgi (GO:0000042)	4.00876459
19	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.96897203
20	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.92973968
21	acrosome reaction (GO:0007340)	3.86634660
22	establishment of protein localization to Golgi (GO:0072600)	3.75321167
23	digestion (GO:0007586)	3.74125682
24	adult feeding behavior (GO:0008343)	3.68718433
25	male sex determination (GO:0030238)	3.61163847
26	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.59525467
27	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.59525467
28	negative regulation of inclusion body assembly (GO:0090084)	3.57811199
29	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.56211783
30	negative regulation of gene silencing (GO:0060969)	3.55590797
31	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.47011730
32	negative regulation of hormone biosynthetic process (GO:0032353)	3.45790791
33	male meiosis I (GO:0007141)	3.45264476
34	sperm capacitation (GO:0048240)	3.41092179
35	nucleoside diphosphate catabolic process (GO:0009134)	3.40595247
36	intraciliary transport (GO:0042073)	3.34997500
37	regulation of male gonad development (GO:2000018)	3.33642020
38	glutathione biosynthetic process (GO:0006750)	3.33442029
39	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	3.33146425
40	fusion of sperm to egg plasma membrane (GO:0007342)	3.32727709
41	glandular epithelial cell development (GO:0002068)	3.29624144
42	microtubule polymerization or depolymerization (GO:0031109)	3.27754259
43	cilium assembly (GO:0042384)	3.17602662
44	protein localization to cilium (GO:0061512)	3.17507082
45	cilium organization (GO:0044782)	3.16996442
46	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	3.16607725
47	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	3.15140040
48	intestinal cholesterol absorption (GO:0030299)	3.13849851
49	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.12347541
50	negative regulation of hormone metabolic process (GO:0032351)	3.10111484
51	negative regulation of acute inflammatory response (GO:0002674)	3.09990961
52	multicellular organism reproduction (GO:0032504)	3.04518995
53	regulation of response to food (GO:0032095)	3.03881046
54	spermatid development (GO:0007286)	3.03479903
55	maintenance of gastrointestinal epithelium (GO:0030277)	3.02789895
56	endocrine pancreas development (GO:0031018)	3.02725842
57	cellular ketone body metabolic process (GO:0046950)	3.02424450
58	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	3.00234287
59	retinol metabolic process (GO:0042572)	2.99007241
60	cell proliferation involved in kidney development (GO:0072111)	2.98334762
61	cysteine metabolic process (GO:0006534)	2.97093472
62	phosphatidylethanolamine metabolic process (GO:0046337)	2.93382908
63	dopamine transport (GO:0015872)	2.91194683
64	microtubule depolymerization (GO:0007019)	2.89788180
65	lung epithelium development (GO:0060428)	2.88359784
66	cell proliferation involved in metanephros development (GO:0072203)	2.88124626
67	meiosis I (GO:0007127)	2.87235802
68	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.86817873
69	diterpenoid biosynthetic process (GO:0016102)	2.85935926
70	left/right pattern formation (GO:0060972)	2.83143646
71	piRNA metabolic process (GO:0034587)	2.82778974
72	leukotriene biosynthetic process (GO:0019370)	2.82270485
73	ventricular system development (GO:0021591)	2.77684280
74	nonmotile primary cilium assembly (GO:0035058)	2.76779067
75	nonribosomal peptide biosynthetic process (GO:0019184)	2.75853939
76	intra-Golgi vesicle-mediated transport (GO:0006891)	2.75008510
77	epithelial cell fate commitment (GO:0072148)	2.72757870
78	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.72550696
79	regulation of metalloenzyme activity (GO:0048552)	2.70693489
80	inner ear receptor cell differentiation (GO:0060113)	2.69457140
81	insulin secretion (GO:0030073)	2.69419434
82	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.67933325
83	regulation of cellular amino acid metabolic process (GO:0006521)	2.67865258
84	ketone body metabolic process (GO:1902224)	2.67728082
85	glandular epithelial cell differentiation (GO:0002067)	2.67590942
86	peptidyl-threonine dephosphorylation (GO:0035970)	2.63386955
87	columnar/cuboidal epithelial cell development (GO:0002066)	2.63164409
88	one-carbon compound transport (GO:0019755)	2.62876147
89	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.61392332
90	calcium ion-dependent exocytosis (GO:0017156)	2.59414503
91	DNA methylation involved in gamete generation (GO:0043046)	2.59092049
92	rRNA methylation (GO:0031167)	2.57999617
93	cell differentiation involved in metanephros development (GO:0072202)	2.56638669
94	microtubule bundle formation (GO:0001578)	2.55432731
95	sperm-egg recognition (GO:0035036)	2.54050771
96	artery smooth muscle contraction (GO:0014824)	2.53629671
97	regulation of beta-amyloid formation (GO:1902003)	2.52600900
98	male meiosis (GO:0007140)	2.52011912
99	post-embryonic morphogenesis (GO:0009886)	2.50527751
100	spermatogenesis (GO:0007283)	2.49833344

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.57790123
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.87692534
3	VDR_22108803_ChIP-Seq_LS180_Human	3.41695763
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.08613605
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.54009746
6	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.24805346
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20901126
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.16164524
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11215469
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90341747
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88380512
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.86073223
13	BCAT_22108803_ChIP-Seq_LS180_Human	1.85099077
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84442491
15	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.67357267
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.64699380
17	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64360925
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.61722324
19	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.58981737
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.57228399
21	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50701499
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.49791389
23	AR_25329375_ChIP-Seq_VCAP_Human	1.46547070
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.45307528
25	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44399355
26	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44399355
27	ERA_21632823_ChIP-Seq_H3396_Human	1.40952288
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.40943964
29	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40303191
30	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.37079648
31	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.35230439
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.35106677
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.33976533
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.33288871
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31880200
36	P300_19829295_ChIP-Seq_ESCs_Human	1.29059842
37	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.29040369
38	DROSHA_22980978_ChIP-Seq_HELA_Human	1.27424331
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27365448
40	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26950243
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26340273
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26340273
43	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25083332
44	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.24427204
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22871434
46	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.22097211
47	FUS_26573619_Chip-Seq_HEK293_Human	1.21877162
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.21543388
49	GATA4_25053715_ChIP-Seq_YYC3_Human	1.21248879
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20051748
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20047245
52	TP53_18474530_ChIP-ChIP_U2OS_Human	1.19882229
53	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19486248
54	RXR_22108803_ChIP-Seq_LS180_Human	1.16712462
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15990923
56	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15239216
57	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.15165878
58	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.14926669
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14219397
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12510137
61	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11859208
62	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.10653156
63	* CBP_20019798_ChIP-Seq_JUKART_Human	1.10323649
64	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10323649
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10150102
66	AR_20517297_ChIP-Seq_VCAP_Human	1.08654083
67	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.08253655
68	ETV1_20927104_ChIP-Seq_GIST48_Human	1.07185132
69	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.06647785
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05963174
71	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.03864104
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03541426
73	* KLF5_25053715_ChIP-Seq_YYC3_Human	1.03429713
74	PHF8_20622853_ChIP-Seq_HELA_Human	1.03158015
75	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.02488778
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.02342026
77	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01580438
78	TP53_22573176_ChIP-Seq_HFKS_Human	0.99876831
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.99374030
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97909341
81	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.97906990
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97684341
83	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.97274084
84	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97012373
85	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96552905
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96349126
87	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95555242
88	RBPJ_21746931_ChIP-Seq_IB4_Human	0.94345396
89	E2F1_20622854_ChIP-Seq_HELA_Human	0.94033257
90	* MYC_19829295_ChIP-Seq_ESCs_Human	0.93315389
91	OCT4_20526341_ChIP-Seq_ESCs_Human	0.92835413
92	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92774061
93	P300_27268052_Chip-Seq_Bcells_Human	0.92185730
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.91475245
95	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.90953576
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90104107
97	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.88808886
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.88731180
99	TP63_23658742_ChIP-Seq_EP156T_Human	0.86832862
100	REST_21632747_ChIP-Seq_MESCs_Mouse	0.86501580

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	4.79862703
2	MP0009780_abnormal_chondrocyte_physiolo	4.71049299
3	MP0003011_delayed_dark_adaptation	4.48497750
4	MP0003283_abnormal_digestive_organ	4.31302979
5	MP0002909_abnormal_adrenal_gland	3.24185379
6	MP0002876_abnormal_thyroid_physiology	3.15883112
7	MP0005083_abnormal_biliary_tract	2.98823691
8	MP0003136_yellow_coat_color	2.79554468
9	MP0005410_abnormal_fertilization	2.44239432
10	MP0005670_abnormal_white_adipose	2.24229517
11	MP0002282_abnormal_trachea_morphology	2.21397526
12	MP0001661_extended_life_span	2.08604481
13	MP0005379_endocrine/exocrine_gland_phen	2.05934503
14	MP0006072_abnormal_retinal_apoptosis	2.00552820
15	MP0005253_abnormal_eye_physiology	1.95913149
16	MP0010678_abnormal_skin_adnexa	1.95182188
17	MP0008875_abnormal_xenobiotic_pharmacok	1.87907152
18	MP0000383_abnormal_hair_follicle	1.85979059
19	MP0000462_abnormal_digestive_system	1.82225637
20	MP0001944_abnormal_pancreas_morphology	1.78001684
21	MP0000013_abnormal_adipose_tissue	1.75232275
22	MP0005645_abnormal_hypothalamus_physiol	1.74225355
23	MP0002163_abnormal_gland_morphology	1.72317955
24	MP0002822_catalepsy	1.72154563
25	MP0001929_abnormal_gametogenesis	1.71620682
26	MP0010234_abnormal_vibrissa_follicle	1.70536451
27	MP0002249_abnormal_larynx_morphology	1.67631617
28	MP0005451_abnormal_body_composition	1.66162483
29	MP0001984_abnormal_olfaction	1.64200894
30	MP0004043_abnormal_pH_regulation	1.59873983
31	MP0005551_abnormal_eye_electrophysiolog	1.53227235
32	MP0000613_abnormal_salivary_gland	1.50429257
33	MP0003698_abnormal_male_reproductive	1.46982053
34	MP0000427_abnormal_hair_cycle	1.45137408
35	MP0002638_abnormal_pupillary_reflex	1.42516411
36	MP0001485_abnormal_pinna_reflex	1.40619543
37	MP0005257_abnormal_intraocular_pressure	1.39120236
38	MP0002928_abnormal_bile_duct	1.36640532
39	MP0003195_calcinosis	1.35660406
40	MP0005248_abnormal_Harderian_gland	1.34492541
41	MP0008877_abnormal_DNA_methylation	1.34030825
42	MP0001664_abnormal_digestion	1.29801794
43	MP0002210_abnormal_sex_determination	1.28624778
44	MP0000569_abnormal_digit_pigmentation	1.27278904
45	MP0001765_abnormal_ion_homeostasis	1.25474251
46	MP0004019_abnormal_vitamin_homeostasis	1.24968955
47	MP0005085_abnormal_gallbladder_physiolo	1.24826560
48	MP0010030_abnormal_orbit_morphology	1.23115414
49	MP0001905_abnormal_dopamine_level	1.20716867
50	MP0010386_abnormal_urinary_bladder	1.17855095
51	MP0005075_abnormal_melanosome_morpholog	1.17316768
52	MP0000538_abnormal_urinary_bladder	1.16834399
53	MP0002332_abnormal_exercise_endurance	1.13511176
54	MP0003119_abnormal_digestive_system	1.12854203
55	MP0000647_abnormal_sebaceous_gland	1.08620397
56	MP0002735_abnormal_chemical_nociception	1.04450241
57	MP0002693_abnormal_pancreas_physiology	1.02673670
58	MP0005636_abnormal_mineral_homeostasis	1.02648515
59	MP0001666_abnormal_nutrient_absorption	1.02105671
60	MP0000653_abnormal_sex_gland	1.00589746
61	MP0000026_abnormal_inner_ear	1.00440015
62	MP0003123_paternal_imprinting	0.99148627
63	MP0001145_abnormal_male_reproductive	0.98826881
64	MP0003806_abnormal_nucleotide_metabolis	0.96757428
65	MP0001963_abnormal_hearing_physiology	0.95842471
66	MP0002098_abnormal_vibrissa_morphology	0.94733234
67	MP0005332_abnormal_amino_acid	0.94605925
68	MP0003866_abnormal_defecation	0.94456214
69	MP0009046_muscle_twitch	0.93808446
70	MP0002229_neurodegeneration	0.93348367
71	MP0005365_abnormal_bile_salt	0.90824211
72	MP0003936_abnormal_reproductive_system	0.89883530
73	MP0002067_abnormal_sensory_capabilities	0.88262070
74	MP0000631_abnormal_neuroendocrine_gland	0.88235625
75	MP0006036_abnormal_mitochondrial_physio	0.85939050
76	MP0002837_dystrophic_cardiac_calcinosis	0.84916211
77	MP0003656_abnormal_erythrocyte_physiolo	0.84729270
78	MP0003718_maternal_effect	0.83946403
79	MP0003943_abnormal_hepatobiliary_system	0.83405781
80	MP0005391_vision/eye_phenotype	0.81952055
81	MP0003953_abnormal_hormone_level	0.79663113
82	MP0000371_diluted_coat_color	0.79425644
83	MP0006292_abnormal_olfactory_placode	0.77152431
84	MP0000681_abnormal_thyroid_gland	0.76695886
85	MP0005220_abnormal_exocrine_pancreas	0.76510946
86	MP0003879_abnormal_hair_cell	0.75818617
87	MP0005310_abnormal_salivary_gland	0.75231236
88	MP0003938_abnormal_ear_development	0.75168057
89	MP0000639_abnormal_adrenal_gland	0.74444438
90	MP0009745_abnormal_behavioral_response	0.74279707
91	MP0010329_abnormal_lipoprotein_level	0.70804934
92	MP0003252_abnormal_bile_duct	0.70709694
93	MP0005367_renal/urinary_system_phenotyp	0.69837826
94	MP0000516_abnormal_urinary_system	0.69837826
95	MP0002734_abnormal_mechanical_nocicepti	0.67938688
96	MP0002095_abnormal_skin_pigmentation	0.67584111
97	MP0001970_abnormal_pain_threshold	0.63693824
98	MP0002078_abnormal_glucose_homeostasis	0.63434639
99	MP0006276_abnormal_autonomic_nervous	0.63203406
100	MP0002161_abnormal_fertility/fecundity	0.62897660

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.18714476
2	Abnormal ciliary motility (HP:0012262)	5.74217157
3	Abnormal respiratory motile cilium physiology (HP:0012261)	5.59176035
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.34185185
5	Absent/shortened dynein arms (HP:0200106)	5.34185185
6	Abnormal respiratory epithelium morphology (HP:0012253)	5.33122512
7	Abnormal respiratory motile cilium morphology (HP:0005938)	5.33122512
8	Rhinitis (HP:0012384)	4.97994657
9	Congenital stationary night blindness (HP:0007642)	4.28348753
10	Glucose intolerance (HP:0000833)	3.67565693
11	Nasal polyposis (HP:0100582)	3.65438834
12	Abnormal sex determination (HP:0012244)	3.62079348
13	Sex reversal (HP:0012245)	3.62079348
14	Chronic bronchitis (HP:0004469)	3.61882217
15	Abnormal pancreas size (HP:0012094)	3.53837560
16	Congenital, generalized hypertrichosis (HP:0004540)	3.45800868
17	Bronchiectasis (HP:0002110)	3.45675114
18	Chronic sinusitis (HP:0011109)	3.45397937
19	Tubulointerstitial nephritis (HP:0001970)	3.42820850
20	True hermaphroditism (HP:0010459)	3.35259813
21	Abnormality of the distal phalanges of the toes (HP:0010182)	3.14046730
22	Exocrine pancreatic insufficiency (HP:0001738)	3.00371676
23	Insulin-resistant diabetes mellitus (HP:0000831)	2.91821376
24	Type II lissencephaly (HP:0007260)	2.87915770
25	Hypokinesia (HP:0002375)	2.80562966
26	Bronchitis (HP:0012387)	2.74281674
27	Abnormality of the renal cortex (HP:0011035)	2.73060552
28	Abnormality of the nasal mucosa (HP:0000433)	2.70370563
29	Tubular atrophy (HP:0000092)	2.61874565
30	Congenital sensorineural hearing impairment (HP:0008527)	2.60456313
31	Steatorrhea (HP:0002570)	2.60102619
32	Medial flaring of the eyebrow (HP:0010747)	2.54988762
33	Gait imbalance (HP:0002141)	2.51892136
34	Pili torti (HP:0003777)	2.51103641
35	Chronic hepatic failure (HP:0100626)	2.50700674
36	Pancreatic fibrosis (HP:0100732)	2.49915839
37	Broad face (HP:0000283)	2.45733723
38	Short nail (HP:0001799)	2.42684732
39	Abnormal glucose tolerance (HP:0001952)	2.40598836
40	Bell-shaped thorax (HP:0001591)	2.37970391
41	Abnormality of the renal medulla (HP:0100957)	2.37598335
42	Hyperkalemia (HP:0002153)	2.37306244
43	Congenital primary aphakia (HP:0007707)	2.35214292
44	Disproportionate short-trunk short stature (HP:0003521)	2.34931573
45	Growth hormone excess (HP:0000845)	2.32980383
46	Menstrual irregularities (HP:0000858)	2.29512989
47	Nephronophthisis (HP:0000090)	2.27933906
48	Pancreatic cysts (HP:0001737)	2.26874137
49	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.25094607
50	Infertility (HP:0000789)	2.21564303
51	Abnormal hair laboratory examination (HP:0003328)	2.18686278
52	Hepatocellular necrosis (HP:0001404)	2.18140738
53	Depressed nasal tip (HP:0000437)	2.17077041
54	Median cleft lip (HP:0000161)	2.15939364
55	Down-sloping shoulders (HP:0200021)	2.15313540
56	Recurrent bronchitis (HP:0002837)	2.14056301
57	Fetal akinesia sequence (HP:0001989)	2.13183662
58	Hepatic necrosis (HP:0002605)	2.12546830
59	Abnormality of the middle phalanges of the toes (HP:0010183)	2.11778270
60	Recurrent otitis media (HP:0000403)	2.11712211
61	Hypoproteinemia (HP:0003075)	2.09511546
62	Hypoplasia of the pons (HP:0012110)	2.09119190
63	Retinal dysplasia (HP:0007973)	2.06936473
64	Optic nerve coloboma (HP:0000588)	2.03488400
65	Amelogenesis imperfecta (HP:0000705)	2.01702964
66	Hypomagnesemia (HP:0002917)	2.01178031
67	Azoospermia (HP:0000027)	1.99909351
68	Occipital encephalocele (HP:0002085)	1.97804407
69	Molar tooth sign on MRI (HP:0002419)	1.95937165
70	Abnormality of midbrain morphology (HP:0002418)	1.95937165
71	Acanthocytosis (HP:0001927)	1.92817585
72	Adrenal hypoplasia (HP:0000835)	1.92121763
73	Cystic liver disease (HP:0006706)	1.91330759
74	Fat malabsorption (HP:0002630)	1.91265774
75	Axonal loss (HP:0003447)	1.90833023
76	Nephrogenic diabetes insipidus (HP:0009806)	1.90670478
77	Abnormality of macular pigmentation (HP:0008002)	1.88181083
78	Goiter (HP:0000853)	1.88049598
79	Anophthalmia (HP:0000528)	1.86724536
80	Gout (HP:0001997)	1.85415295
81	Glossoptosis (HP:0000162)	1.85240927
82	Recurrent sinusitis (HP:0011108)	1.83275699
83	Hyperuricemia (HP:0002149)	1.82200006
84	Increased purine levels (HP:0004368)	1.82200006
85	Tongue fasciculations (HP:0001308)	1.82198465
86	Male pseudohermaphroditism (HP:0000037)	1.82120458
87	Insulin resistance (HP:0000855)	1.79832087
88	Abnormality of the pons (HP:0007361)	1.79733232
89	Woolly hair (HP:0002224)	1.78708124
90	Mitochondrial inheritance (HP:0001427)	1.77548741
91	Genital tract atresia (HP:0001827)	1.75269165
92	Vaginal atresia (HP:0000148)	1.73723751
93	Sparse eyelashes (HP:0000653)	1.73466345
94	Unilateral renal agenesis (HP:0000122)	1.72380276
95	Increased CSF lactate (HP:0002490)	1.71890930
96	Sclerocornea (HP:0000647)	1.70770963
97	Hydroxyprolinuria (HP:0003080)	1.70559727
98	Abnormality of proline metabolism (HP:0010907)	1.70559727
99	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69707989
100	Abnormality of magnesium homeostasis (HP:0004921)	1.68255561

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	6.88845959
2	NME1	5.93569517
3	MST1R	4.13060155
4	MST4	3.53511327
5	STK38L	3.05075002
6	GRK1	3.04704857
7	MAPK15	2.91825993
8	EPHA2	2.66100647
9	PNCK	2.43940734
10	PINK1	2.43241800
11	BMPR1B	2.33366786
12	PASK	2.23481792
13	MAPKAPK3	1.95522085
14	FRK	1.87482504
15	MAP3K6	1.80520415
16	STK24	1.80013306
17	ACVR1B	1.78021914
18	TRIM28	1.76321080
19	MAP3K2	1.75723836
20	STK38	1.73626829
21	MET	1.57544010
22	WNK4	1.50471850
23	MAP4K2	1.44693310
24	PHKG2	1.43137631
25	PHKG1	1.43137631
26	TESK1	1.39421832
27	PLK4	1.34211354
28	TRPM7	1.28514361
29	CDK8	1.25208433
30	EIF2AK1	1.22608215
31	ZAK	1.15749570
32	ERBB3	1.12638901
33	MAP2K6	1.10865849
34	MAP3K9	1.10064580
35	FGFR2	1.06787906
36	VRK2	1.03089424
37	WNK1	0.99794666
38	TSSK6	0.96008598
39	STK16	0.87931092
40	PLK2	0.86255644
41	MAP2K2	0.85910292
42	INSRR	0.85791774
43	PRKCI	0.84198604
44	PTK2B	0.83160864
45	TNIK	0.77576583
46	MAP3K12	0.74824823
47	CASK	0.72653375
48	LMTK2	0.67261266
49	CAMK1G	0.67255400
50	HIPK2	0.53234563
51	DYRK3	0.53157861
52	CAMK1D	0.51413541
53	SIK1	0.51239254
54	ADRBK1	0.50614569
55	EIF2AK2	0.48814207
56	DAPK1	0.46760097
57	GRK7	0.43683302
58	MAP2K1	0.43354078
59	STK39	0.42026864
60	MAP3K4	0.38327416
61	PBK	0.36344872
62	DYRK2	0.35341429
63	WEE1	0.35179265
64	CAMK2D	0.34433815
65	ADRBK2	0.33699245
66	CCNB1	0.33468277
67	STK3	0.31541772
68	ABL2	0.29456704
69	PTK2	0.27874077
70	EIF2AK3	0.27834507
71	ROCK1	0.27288190
72	STK10	0.27013599
73	LATS2	0.26926603
74	ZAP70	0.26888847
75	FER	0.25502665
76	PRKG2	0.25487631
77	OXSR1	0.25438265
78	TTK	0.24207083
79	LRRK2	0.24205878
80	PDGFRB	0.20682315
81	PRKACA	0.20486544
82	LIMK1	0.19727279
83	SGK1	0.17798630
84	CAMK2G	0.17596982
85	ERBB2	0.16973397
86	PRKCG	0.16214550
87	BRSK2	0.15556730
88	ICK	0.15261139
89	MAP3K3	0.15205314
90	IGF1R	0.14813130
91	MAP2K4	0.13730339
92	PRKCE	0.12589051
93	RPS6KA5	0.12178556
94	TBK1	0.11740245
95	FGFR1	0.11499944
96	NTRK3	0.11483693
97	PRKCQ	0.10621009
98	TGFBR1	0.10450920
99	ERBB4	0.10028343
100	CAMK2A	0.09834523

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	5.35877236
2	Sulfur metabolism_Homo sapiens_hsa00920	3.92312761
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.58834256
4	Phototransduction_Homo sapiens_hsa04744	2.63432470
5	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.60913523
6	Protein export_Homo sapiens_hsa03060	2.42617689
7	Folate biosynthesis_Homo sapiens_hsa00790	2.29564086
8	Proteasome_Homo sapiens_hsa03050	2.23874232
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.17997568
10	Regulation of autophagy_Homo sapiens_hsa04140	1.74061665
11	Insulin secretion_Homo sapiens_hsa04911	1.71049234
12	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.69517136
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.67531443
14	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.65820004
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.61533904
16	Huntingtons disease_Homo sapiens_hsa05016	1.56275491
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.52504577
18	Pancreatic secretion_Homo sapiens_hsa04972	1.50946536
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.50337214
20	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.49139370
21	Caffeine metabolism_Homo sapiens_hsa00232	1.43773288
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.39449847
23	Sulfur relay system_Homo sapiens_hsa04122	1.37291032
24	Glutathione metabolism_Homo sapiens_hsa00480	1.35737851
25	Retinol metabolism_Homo sapiens_hsa00830	1.34796856
26	Protein digestion and absorption_Homo sapiens_hsa04974	1.31740670
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30167194
28	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.28035690
29	Nicotine addiction_Homo sapiens_hsa05033	1.27014240
30	Sphingolipid metabolism_Homo sapiens_hsa00600	1.26737472
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25583077
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.25072020
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.24431975
34	Taste transduction_Homo sapiens_hsa04742	1.18932911
35	Parkinsons disease_Homo sapiens_hsa05012	1.16863077
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13907751
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13707559
38	Legionellosis_Homo sapiens_hsa05134	1.12976697
39	Butanoate metabolism_Homo sapiens_hsa00650	1.09444211
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06702068
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03510236
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.01479241
43	Type II diabetes mellitus_Homo sapiens_hsa04930	1.00327563
44	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99521015
45	ABC transporters_Homo sapiens_hsa02010	0.97464336
46	Mineral absorption_Homo sapiens_hsa04978	0.96568211
47	Olfactory transduction_Homo sapiens_hsa04740	0.93911450
48	Purine metabolism_Homo sapiens_hsa00230	0.93171934
49	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.88933246
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88572988
51	Alzheimers disease_Homo sapiens_hsa05010	0.87647329
52	Peroxisome_Homo sapiens_hsa04146	0.87621610
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.86769047
54	Basal transcription factors_Homo sapiens_hsa03022	0.84790070
55	Circadian rhythm_Homo sapiens_hsa04710	0.83377270
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.80978162
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80186169
58	Tyrosine metabolism_Homo sapiens_hsa00350	0.79632748
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75424983
60	Serotonergic synapse_Homo sapiens_hsa04726	0.74361309
61	Propanoate metabolism_Homo sapiens_hsa00640	0.74211177
62	Bile secretion_Homo sapiens_hsa04976	0.73598800
63	Tight junction_Homo sapiens_hsa04530	0.73044060
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72825894
65	Salivary secretion_Homo sapiens_hsa04970	0.72394279
66	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.68492314
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66581219
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.64590228
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63822997
70	Histidine metabolism_Homo sapiens_hsa00340	0.63536577
71	Metabolic pathways_Homo sapiens_hsa01100	0.63388577
72	One carbon pool by folate_Homo sapiens_hsa00670	0.62286875
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62263060
74	Cocaine addiction_Homo sapiens_hsa05030	0.60904500
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.60608333
76	Fatty acid elongation_Homo sapiens_hsa00062	0.60151434
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.59007290
78	GABAergic synapse_Homo sapiens_hsa04727	0.57035340
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55913226
80	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54533212
81	Linoleic acid metabolism_Homo sapiens_hsa00591	0.54430274
82	Morphine addiction_Homo sapiens_hsa05032	0.52456609
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49970341
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48850706
85	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48435559
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46918531
87	Homologous recombination_Homo sapiens_hsa03440	0.42662520
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.42621588
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41280817
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.40702937
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.39913028
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.39346103
93	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.39346082
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39183555
95	Renin secretion_Homo sapiens_hsa04924	0.37514313
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.35204400
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34999359
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.33717894
99	Amphetamine addiction_Homo sapiens_hsa05031	0.33031441
100	Circadian entrainment_Homo sapiens_hsa04713	0.28641826

C2ORF70

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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