C2ORF72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)6.90389482
2regulation of fibrinolysis (GO:0051917)6.48204568
3regulation of protein activation cascade (GO:2000257)6.31962709
4regulation of complement activation (GO:0030449)6.00487634
5peptidyl-glutamic acid carboxylation (GO:0017187)5.99796154
6protein carboxylation (GO:0018214)5.99796154
7very-low-density lipoprotein particle assembly (GO:0034379)5.66424295
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.66113867
9L-phenylalanine catabolic process (GO:0006559)5.66113867
10regulation of cholesterol esterification (GO:0010872)5.60311815
11plasma lipoprotein particle assembly (GO:0034377)5.51323289
12complement activation, alternative pathway (GO:0006957)5.43985651
13plasma lipoprotein particle remodeling (GO:0034369)5.36390560
14protein-lipid complex remodeling (GO:0034368)5.36390560
15macromolecular complex remodeling (GO:0034367)5.36390560
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.29597570
17L-phenylalanine metabolic process (GO:0006558)5.29597570
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.24760311
19high-density lipoprotein particle remodeling (GO:0034375)5.21783211
20cholesterol efflux (GO:0033344)5.19238534
21negative regulation of cholesterol transport (GO:0032375)5.08952904
22negative regulation of sterol transport (GO:0032372)5.08952904
23reverse cholesterol transport (GO:0043691)5.01927728
24low-density lipoprotein particle remodeling (GO:0034374)4.99720009
25protein-lipid complex assembly (GO:0065005)4.97402587
26intestinal cholesterol absorption (GO:0030299)4.88936505
27blood coagulation, intrinsic pathway (GO:0007597)4.84993821
28plasma lipoprotein particle organization (GO:0071827)4.60263711
29phospholipid efflux (GO:0033700)4.57690544
30regulation of plasminogen activation (GO:0010755)4.53102575
31epoxygenase P450 pathway (GO:0019373)4.40464887
32protein-lipid complex subunit organization (GO:0071825)4.36371181
33ethanol oxidation (GO:0006069)4.28194146
34regulation of apoptotic cell clearance (GO:2000425)4.11987971
35plasma lipoprotein particle clearance (GO:0034381)4.08553146
36glutamate metabolic process (GO:0006536)4.07951719
37glyoxylate metabolic process (GO:0046487)4.07600380
38fibrinolysis (GO:0042730)4.05530393
39positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.00222247
40regulation of bile acid biosynthetic process (GO:0070857)3.88301929
41negative regulation of protein activation cascade (GO:2000258)3.87404197
42exogenous drug catabolic process (GO:0042738)3.81774315
43positive regulation of triglyceride lipase activity (GO:0061365)3.77020143
44positive regulation of lipoprotein lipase activity (GO:0051006)3.77020143
45protein activation cascade (GO:0072376)3.74900217
46drug catabolic process (GO:0042737)3.71057056
47regulation of cholesterol homeostasis (GO:2000188)3.68959809
48negative regulation of lipase activity (GO:0060192)3.68708402
49urea metabolic process (GO:0019627)3.67825735
50triglyceride homeostasis (GO:0070328)3.64768187
51acylglycerol homeostasis (GO:0055090)3.64768187
52regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.64753857
53negative regulation of blood coagulation (GO:0030195)3.63687242
54negative regulation of hemostasis (GO:1900047)3.63687242
55acute-phase response (GO:0006953)3.62069726
56regulation of cholesterol biosynthetic process (GO:0045540)3.61077308
57proline metabolic process (GO:0006560)3.53244762
58aromatic amino acid family catabolic process (GO:0009074)3.51131575
59complement activation, classical pathway (GO:0006958)3.50361686
60omega-hydroxylase P450 pathway (GO:0097267)3.48989248
61intestinal absorption (GO:0050892)3.48666906
62cellular glucuronidation (GO:0052695)3.44451647
63regulation of humoral immune response (GO:0002920)3.44036501
64positive regulation of fatty acid biosynthetic process (GO:0045723)3.39020723
65ethanol metabolic process (GO:0006067)3.36128921
66lipoprotein metabolic process (GO:0042157)3.34621665
67urea cycle (GO:0000050)3.34196371
68positive regulation of blood coagulation (GO:0030194)3.32282457
69positive regulation of hemostasis (GO:1900048)3.32282457
70bile acid metabolic process (GO:0008206)3.30238712
71dicarboxylic acid biosynthetic process (GO:0043650)3.29982426
72negative regulation of coagulation (GO:0050819)3.29538295
73serine family amino acid catabolic process (GO:0009071)3.27729186
74axon ensheathment in central nervous system (GO:0032291)3.27453442
75central nervous system myelination (GO:0022010)3.27453442
76nitrogen cycle metabolic process (GO:0071941)3.26750344
77cholesterol homeostasis (GO:0042632)3.26555240
78cholesterol transport (GO:0030301)3.25549250
79sterol transport (GO:0015918)3.25549250
80glucuronate metabolic process (GO:0019585)3.24265422
81uronic acid metabolic process (GO:0006063)3.24265422
82diacylglycerol metabolic process (GO:0046339)3.22721595
83negative regulation of wound healing (GO:0061045)3.22170253
84sterol homeostasis (GO:0055092)3.21319527
85neurotransmitter-gated ion channel clustering (GO:0072578)3.20207902
86complement activation (GO:0006956)3.18331413
87renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.17817852
88positive regulation of steroid metabolic process (GO:0045940)3.09949532
89positive regulation of extracellular matrix organization (GO:1903055)3.05232891
90regulation of cholesterol metabolic process (GO:0090181)3.04539452
91positive regulation of coagulation (GO:0050820)3.03409588
92cellular sodium ion homeostasis (GO:0006883)3.03235424
93regulation of triglyceride catabolic process (GO:0010896)3.02951770
94drug metabolic process (GO:0017144)3.02604274
95bile acid and bile salt transport (GO:0015721)3.00179032
96embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98676096
97phospholipid homeostasis (GO:0055091)2.95660720
98C4-dicarboxylate transport (GO:0015740)2.95462077
99glutamine family amino acid biosynthetic process (GO:0009084)2.93185866
100positive regulation of lipid catabolic process (GO:0050996)2.93129903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.39431066
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.27799250
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.66517555
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.48611583
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.07592853
6FOXA2_19822575_ChIP-Seq_HepG2_Human2.98290288
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.90073324
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85451540
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.67419792
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55186040
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.53820661
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28081839
13HNF4A_19822575_ChIP-Seq_HepG2_Human2.11447403
14EZH2_22144423_ChIP-Seq_EOC_Human1.87991547
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86692424
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.85323810
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82312054
18CDX2_20551321_ChIP-Seq_CACO-2_Human1.81798385
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78053550
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72914433
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.72679146
22DROSHA_22980978_ChIP-Seq_HELA_Human1.70294523
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68397192
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.66260646
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65555115
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64312378
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62681469
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55758081
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51375951
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51375951
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50575395
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46740751
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46739531
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39769611
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.36626440
36AR_21572438_ChIP-Seq_LNCaP_Human1.35984300
37REST_21632747_ChIP-Seq_MESCs_Mouse1.33990732
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33010211
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31232427
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28570817
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27663062
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25707097
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25520492
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25169698
45CLOCK_20551151_ChIP-Seq_293T_Human1.24685370
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23511427
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.23456645
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22040634
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21849750
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.18569135
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17534491
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17377642
53GBX2_23144817_ChIP-Seq_PC3_Human1.15923381
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.12464759
55LXR_22292898_ChIP-Seq_THP-1_Human1.11166672
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08176412
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.05434498
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05376591
59ZNF263_19887448_ChIP-Seq_K562_Human1.04386715
60GATA4_25053715_ChIP-Seq_YYC3_Human1.04034346
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.03237572
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02168942
63POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00357782
64TCF4_18268006_ChIP-ChIP_LS174T_Human0.99757073
65EED_16625203_ChIP-ChIP_MESCs_Mouse0.99455420
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98166458
67SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98157391
68KDM2B_26808549_Chip-Seq_K562_Human0.96503539
69ESR1_20079471_ChIP-ChIP_T-47D_Human0.96330404
70ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94632562
71RING1B_27294783_Chip-Seq_ESCs_Mouse0.93619201
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93576985
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93341849
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92446125
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91892562
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91407425
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90243828
78RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88354332
79CTCF_27219007_Chip-Seq_Bcells_Human0.87672117
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87227110
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85893927
82NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84615558
83WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82866833
84EZH2_27304074_Chip-Seq_ESCs_Mouse0.81263863
85SOX2_20726797_ChIP-Seq_SW620_Human0.80351819
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80022873
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.79966123
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79515600
89SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78965213
90NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78159563
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77322826
92RING1B_27294783_Chip-Seq_NPCs_Mouse0.76502879
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75450223
94MYC_19915707_ChIP-ChIP_AK7_Human0.75127769
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74282217
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73451087
97SMC4_20622854_ChIP-Seq_HELA_Human0.70790972
98MYC_27129775_Chip-Seq_CORNEA_Mouse0.69507084
99GATA6_25053715_ChIP-Seq_YYC3_Human0.69474660
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.68945796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.00703461
2MP0005360_urolithiasis5.33109987
3MP0005365_abnormal_bile_salt4.76453111
4MP0005085_abnormal_gallbladder_physiolo4.48298985
5MP0003195_calcinosis3.77073478
6MP0001666_abnormal_nutrient_absorption3.54388540
7MP0008875_abnormal_xenobiotic_pharmacok3.53468115
8MP0010329_abnormal_lipoprotein_level3.45167879
9MP0003122_maternal_imprinting3.17383010
10MP0000566_synostosis2.82379890
11MP0004270_analgesia2.70094595
12MP0003868_abnormal_feces_composition2.66084000
13MP0003252_abnormal_bile_duct2.58197798
14MP0009840_abnormal_foam_cell2.07844958
15MP0009780_abnormal_chondrocyte_physiolo1.93571155
16MP0005332_abnormal_amino_acid1.89931475
17MP0004859_abnormal_synaptic_plasticity1.87535904
18MP0002089_abnormal_postnatal_growth/wei1.87381395
19MP0003329_amyloid_beta_deposits1.85503525
20MP0002876_abnormal_thyroid_physiology1.79241521
21MP0003690_abnormal_glial_cell1.69508900
22MP0002118_abnormal_lipid_homeostasis1.66517953
23MP0003123_paternal_imprinting1.63617245
24MP0003879_abnormal_hair_cell1.63210329
25MP0002064_seizures1.58260351
26MP0000604_amyloidosis1.52160274
27MP0004019_abnormal_vitamin_homeostasis1.49142509
28MP0002138_abnormal_hepatobiliary_system1.42679227
29MP0000920_abnormal_myelination1.38766273
30MP0000609_abnormal_liver_physiology1.38417727
31MP0003191_abnormal_cellular_cholesterol1.36299587
32MP0003635_abnormal_synaptic_transmissio1.34971358
33MP0005646_abnormal_pituitary_gland1.25588531
34MP0005409_darkened_coat_color1.24900593
35MP0001486_abnormal_startle_reflex1.23843690
36MP0005423_abnormal_somatic_nervous1.23108861
37MP0003633_abnormal_nervous_system1.22373026
38MP0003632_abnormal_nervous_system1.19827474
39MP0003880_abnormal_central_pattern1.15548326
40MP0005167_abnormal_blood-brain_barrier1.15446517
41MP0003172_abnormal_lysosome_physiology1.14953057
42MP0003136_yellow_coat_color1.13813894
43MP0010368_abnormal_lymphatic_system1.13253325
44MP0005408_hypopigmentation1.12472689
45MP0002734_abnormal_mechanical_nocicepti1.11335961
46MP0003631_nervous_system_phenotype1.11095602
47MP0002063_abnormal_learning/memory/cond1.07275371
48MP0002909_abnormal_adrenal_gland1.04736998
49MP0009745_abnormal_behavioral_response1.04452910
50MP0003183_abnormal_peptide_metabolism1.01542505
51MP0001915_intracranial_hemorrhage1.01156746
52MP0005058_abnormal_lysosome_morphology0.99974357
53MP0005636_abnormal_mineral_homeostasis0.97518131
54MP0002272_abnormal_nervous_system0.95802468
55MP0002572_abnormal_emotion/affect_behav0.95137146
56MP0000639_abnormal_adrenal_gland0.93112012
57MP0008569_lethality_at_weaning0.89328486
58MP0002557_abnormal_social/conspecific_i0.88571283
59MP0004885_abnormal_endolymph0.85264713
60MP0009046_muscle_twitch0.83755943
61MP0001764_abnormal_homeostasis0.83100925
62MP0002249_abnormal_larynx_morphology0.81128599
63MP0003634_abnormal_glial_cell0.76837214
64MP0009643_abnormal_urine_homeostasis0.73504281
65MP0002822_catalepsy0.73377031
66MP0003121_genomic_imprinting0.73165323
67MP0005551_abnormal_eye_electrophysiolog0.72092567
68MP0005584_abnormal_enzyme/coenzyme_acti0.70672927
69MP0002971_abnormal_brown_adipose0.69946422
70MP0009642_abnormal_blood_homeostasis0.69793747
71MP0004264_abnormal_extraembryonic_tissu0.67589018
72MP0002078_abnormal_glucose_homeostasis0.67516722
73MP0005670_abnormal_white_adipose0.67303308
74MP0001756_abnormal_urination0.67151307
75MP0003878_abnormal_ear_physiology0.66961417
76MP0005377_hearing/vestibular/ear_phenot0.66961417
77MP0001440_abnormal_grooming_behavior0.66889789
78MP0009697_abnormal_copulation0.66286354
79MP0000598_abnormal_liver_morphology0.66020492
80MP0005451_abnormal_body_composition0.65809014
81MP0005319_abnormal_enzyme/_coenzyme0.65741138
82MP0000955_abnormal_spinal_cord0.65426531
83MP0005448_abnormal_energy_balance0.65126619
84MP0001501_abnormal_sleep_pattern0.64070348
85MP0004742_abnormal_vestibular_system0.63621774
86MP0005084_abnormal_gallbladder_morpholo0.63489614
87MP0003953_abnormal_hormone_level0.62285674
88MP0001984_abnormal_olfaction0.60845050
89MP0001968_abnormal_touch/_nociception0.60788733
90MP0003075_altered_response_to0.59121476
91MP0002067_abnormal_sensory_capabilities0.57339899
92MP0000778_abnormal_nervous_system0.56181709
93MP0005187_abnormal_penis_morphology0.56143747
94MP0002733_abnormal_thermal_nociception0.56078600
95MP0002132_abnormal_respiratory_system0.54933348
96MP0004043_abnormal_pH_regulation0.53883553
97MP0002229_neurodegeneration0.53819648
98MP0004924_abnormal_behavior0.53341506
99MP0005386_behavior/neurological_phenoty0.53341506
100MP0002066_abnormal_motor_capabilities/c0.53152236

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.96305590
2Prolonged partial thromboplastin time (HP:0003645)7.41067102
3Complement deficiency (HP:0004431)7.17078599
4Hypobetalipoproteinemia (HP:0003563)6.72265672
5Joint hemorrhage (HP:0005261)6.06671727
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.84635839
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.77821638
8Abnormality of complement system (HP:0005339)5.41978945
9Abnormality of the common coagulation pathway (HP:0010990)4.84488706
10Xanthomatosis (HP:0000991)4.76079061
11Glomerulonephritis (HP:0000099)4.75709548
12Systemic lupus erythematosus (HP:0002725)4.66932789
13Spontaneous abortion (HP:0005268)4.54260755
14Conjugated hyperbilirubinemia (HP:0002908)4.17297422
15Hypolipoproteinemia (HP:0010981)4.05547002
16Hypercholesterolemia (HP:0003124)3.63799376
17Hemorrhage of the eye (HP:0011885)3.46695749
18Intrahepatic cholestasis (HP:0001406)3.45336862
19Hyperlipoproteinemia (HP:0010980)3.28733050
20Epidermoid cyst (HP:0200040)3.23851872
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.10344546
22Vascular calcification (HP:0004934)3.03136793
23Fat malabsorption (HP:0002630)2.95793653
24Nephritis (HP:0000123)2.78145288
25Abnormality of glutamine family amino acid metabolism (HP:0010902)2.77806154
26Menorrhagia (HP:0000132)2.77729788
27Mitral stenosis (HP:0001718)2.77402718
28Osteomalacia (HP:0002749)2.69197129
29Gingival bleeding (HP:0000225)2.68231491
30Hypoalphalipoproteinemia (HP:0003233)2.66757877
31Acanthocytosis (HP:0001927)2.63216067
32Cardiovascular calcification (HP:0011915)2.58218456
33Hyperglycinemia (HP:0002154)2.47736016
34Abnormality of carpal bone ossification (HP:0006257)2.45453374
35Bronchomalacia (HP:0002780)2.45131179
36Hepatoblastoma (HP:0002884)2.43711702
37Abnormality of the intrinsic pathway (HP:0010989)2.41033506
38Purpura (HP:0000979)2.39732950
39Alacrima (HP:0000522)2.39535204
40Abnormal tarsal ossification (HP:0008369)2.37842682
41Abnormality of serine family amino acid metabolism (HP:0010894)2.35929071
42Abnormality of glycine metabolism (HP:0010895)2.35929071
43Arthropathy (HP:0003040)2.28884880
44Hyperglycinuria (HP:0003108)2.27500375
45Bifid scrotum (HP:0000048)2.21843261
46Hypophosphatemic rickets (HP:0004912)2.21547557
47Focal motor seizures (HP:0011153)2.19911220
48Hydroxyprolinuria (HP:0003080)2.17726647
49Abnormality of proline metabolism (HP:0010907)2.17726647
50Flat acetabular roof (HP:0003180)2.15784051
51Neurofibrillary tangles (HP:0002185)2.13584230
52Rickets (HP:0002748)2.12792557
53Potter facies (HP:0002009)2.11752791
54Facial shape deformation (HP:0011334)2.11752791
55Retinal atrophy (HP:0001105)2.10382895
56Hepatocellular carcinoma (HP:0001402)2.10015533
57Thrombophlebitis (HP:0004418)2.08067626
58Recurrent gram-negative bacterial infections (HP:0005420)2.07381928
59Abnormality of the nasal septum (HP:0000419)2.04137036
60Abnormal hand bone ossification (HP:0010660)2.03143216
61Neonatal short-limb short stature (HP:0008921)2.01075584
62Epileptic encephalopathy (HP:0200134)1.99967232
63Status epilepticus (HP:0002133)1.96574025
64Hyperammonemia (HP:0001987)1.96310253
65Action tremor (HP:0002345)1.94090709
66Abnormal ossification of hand bones (HP:0005921)1.93504797
67Skin nodule (HP:0200036)1.91705379
68Abnormality of pyrimidine metabolism (HP:0004353)1.90796995
69Small epiphyses (HP:0010585)1.90346768
70Broad alveolar ridges (HP:0000187)1.89508843
71Amyloidosis (HP:0011034)1.87669182
72Aplasia involving bones of the upper limbs (HP:0009823)1.82579211
73Aplasia of the phalanges of the hand (HP:0009802)1.82579211
74Aplasia involving bones of the extremities (HP:0009825)1.82579211
75Hypoglycemic coma (HP:0001325)1.80810568
76Myokymia (HP:0002411)1.80405281
77Megalencephaly (HP:0001355)1.78564002
78Widely patent fontanelles and sutures (HP:0004492)1.75122389
79Increased serum pyruvate (HP:0003542)1.73927816
80Focal seizures (HP:0007359)1.73534274
81Abnormality of the lumbar spine (HP:0100712)1.73095221
82Scanning speech (HP:0002168)1.72694202
83Decreased lacrimation (HP:0000633)1.72588883
84Abnormality of the Achilles tendon (HP:0005109)1.72007293
85Impaired pain sensation (HP:0007328)1.71952313
86Abnormality of pain sensation (HP:0010832)1.71952313
87Enlarged kidneys (HP:0000105)1.66777342
88Steatorrhea (HP:0002570)1.66085178
89Delayed CNS myelination (HP:0002188)1.65741788
90Cerebral inclusion bodies (HP:0100314)1.64807821
91Abnormality of glycolysis (HP:0004366)1.61442427
92Vaginal fistula (HP:0004320)1.60274108
93Neonatal death (HP:0003811)1.57721857
94Paraparesis (HP:0002385)1.56516571
95Atonic seizures (HP:0010819)1.56258708
96Pigmentary retinal degeneration (HP:0001146)1.55774504
97Broad palm (HP:0001169)1.55273081
98Partial duplication of thumb phalanx (HP:0009944)1.54505803
99Myocardial infarction (HP:0001658)1.53598240
100Poikilocytosis (HP:0004447)1.52443782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.07562319
2FGFR33.39425669
3EPHA43.26163803
4NTRK33.25981282
5TYRO33.04098895
6CASK2.77445966
7RIPK12.77408994
8ICK2.76425399
9NTRK22.52382336
10FGFR22.49523729
11MARK12.12635553
12WNK42.01961473
13SGK4941.78917989
14SGK2231.78917989
15PIK3CA1.76679412
16PDGFRA1.71988636
17NTRK11.70759028
18TRIB31.68733452
19SIK21.57977746
20DAPK21.42752905
21PRKD31.41482549
22FGFR11.40104799
23ERN11.38634865
24SGK21.32594899
25RET1.30403547
26LMTK21.29444729
27UHMK11.28738156
28ERBB21.28719647
29SIK11.26457565
30MAPK151.26373094
31LATS21.23415121
32PAK61.19727274
33PNCK1.18653033
34MAP3K21.17364548
35PDPK11.15950150
36SGK31.14600316
37CAMKK11.14242298
38KSR21.11856613
39PRKCG1.09283682
40MINK11.06127498
41SGK11.01793415
42AKT31.01263013
43DYRK1B0.97147027
44STK390.96379250
45CDK120.93873051
46MAP3K90.92699509
47EEF2K0.90969206
48MAPK110.90667891
49WNK10.88038545
50PRKAA20.86834362
51PDK10.83619116
52CDK50.83017336
53DDR20.80670665
54PRKCZ0.74845472
55CAMK1D0.74150373
56PRKACG0.73029676
57EPHA20.71804116
58CAMK2B0.71616437
59CAMK1G0.70711644
60RPS6KB10.70160527
61MAP2K40.67250258
62PHKG10.64429643
63PHKG20.64429643
64PRKAA10.63451887
65BRSK10.63400245
66EPHA30.62334477
67CSNK1E0.61368781
68NEK60.61081331
69CAMK2G0.55939862
70MARK20.54583036
71MET0.53603164
72LATS10.53337244
73RPS6KA30.52733153
74PKN20.51558001
75MAPK100.50742180
76MAPK130.50679265
77CDK150.50114818
78STK380.50075701
79SRC0.49529655
80MAPKAPK30.48627409
81CSNK1D0.46055559
82DAPK10.44461879
83CDK11A0.44180775
84PKN10.42757884
85CDK180.42540944
86PTK60.42274574
87CAMK40.41365494
88PRKG10.41261372
89CAMK2D0.40376494
90PINK10.39161930
91MAPKAPK50.39115280
92MAP3K10.37556092
93DYRK1A0.37384678
94MST1R0.36322916
95PRKG20.36254986
96CAMK2A0.35357745
97ALK0.33262332
98FYN0.32529686
99CDK140.31910434
100MAP2K60.31232022

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.29035316
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.76092381
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95664851
4Arginine biosynthesis_Homo sapiens_hsa002202.76044976
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.58401873
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.46924932
7Histidine metabolism_Homo sapiens_hsa003402.42944032
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37598374
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31212901
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29525121
11Fatty acid degradation_Homo sapiens_hsa000712.22629072
12Retinol metabolism_Homo sapiens_hsa008302.19162861
13Bile secretion_Homo sapiens_hsa049762.14639730
14Phenylalanine metabolism_Homo sapiens_hsa003602.14380884
15Caffeine metabolism_Homo sapiens_hsa002322.00060911
16Chemical carcinogenesis_Homo sapiens_hsa052041.95630289
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.95037772
18Fat digestion and absorption_Homo sapiens_hsa049751.93730178
19PPAR signaling pathway_Homo sapiens_hsa033201.93284288
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91950652
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83000102
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.82644606
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.82475089
24Vitamin B6 metabolism_Homo sapiens_hsa007501.79062651
25Tyrosine metabolism_Homo sapiens_hsa003501.70613789
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62911975
27Butanoate metabolism_Homo sapiens_hsa006501.54805106
28Arginine and proline metabolism_Homo sapiens_hsa003301.51389585
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.48262513
30Starch and sucrose metabolism_Homo sapiens_hsa005001.47087362
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.45049030
32Prion diseases_Homo sapiens_hsa050201.38822260
33Fatty acid metabolism_Homo sapiens_hsa012121.31847915
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27832205
35Tryptophan metabolism_Homo sapiens_hsa003801.23557314
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20732060
37Steroid biosynthesis_Homo sapiens_hsa001001.09499226
38Vitamin digestion and absorption_Homo sapiens_hsa049771.09025342
39Fatty acid biosynthesis_Homo sapiens_hsa000611.07949398
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07046469
41Staphylococcus aureus infection_Homo sapiens_hsa051501.06028110
42ABC transporters_Homo sapiens_hsa020101.05805516
43Peroxisome_Homo sapiens_hsa041461.01059457
44Biosynthesis of amino acids_Homo sapiens_hsa012300.99668440
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98545925
46beta-Alanine metabolism_Homo sapiens_hsa004100.92319597
47Pyruvate metabolism_Homo sapiens_hsa006200.80848954
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78795077
49Propanoate metabolism_Homo sapiens_hsa006400.75927051
50Linoleic acid metabolism_Homo sapiens_hsa005910.74709024
51Thyroid hormone synthesis_Homo sapiens_hsa049180.74655963
52Nicotine addiction_Homo sapiens_hsa050330.74083784
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73456259
54Mineral absorption_Homo sapiens_hsa049780.71748862
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70136861
56Carbon metabolism_Homo sapiens_hsa012000.68362097
57Amphetamine addiction_Homo sapiens_hsa050310.62103247
58Other glycan degradation_Homo sapiens_hsa005110.60260064
59Glycerolipid metabolism_Homo sapiens_hsa005610.60187534
60Nitrogen metabolism_Homo sapiens_hsa009100.58619642
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55901016
62Glutamatergic synapse_Homo sapiens_hsa047240.53800348
63Fructose and mannose metabolism_Homo sapiens_hsa000510.53344894
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51455170
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.51218046
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50835905
67Renin-angiotensin system_Homo sapiens_hsa046140.50769126
68Glucagon signaling pathway_Homo sapiens_hsa049220.49638002
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49546488
70Cocaine addiction_Homo sapiens_hsa050300.48631224
71GABAergic synapse_Homo sapiens_hsa047270.48415063
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.48400630
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48365341
74Long-term potentiation_Homo sapiens_hsa047200.47411313
75Insulin secretion_Homo sapiens_hsa049110.47324609
76Sulfur relay system_Homo sapiens_hsa041220.40591772
77Arachidonic acid metabolism_Homo sapiens_hsa005900.39819620
78Sphingolipid metabolism_Homo sapiens_hsa006000.34981379
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34755001
80Lysine degradation_Homo sapiens_hsa003100.33660906
81Synaptic vesicle cycle_Homo sapiens_hsa047210.29534533
82Sulfur metabolism_Homo sapiens_hsa009200.29441845
83Insulin resistance_Homo sapiens_hsa049310.29334405
84Dopaminergic synapse_Homo sapiens_hsa047280.28392665
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28103193
86Galactose metabolism_Homo sapiens_hsa000520.28083818
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27110771
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.26380654
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26009998
90Metabolic pathways_Homo sapiens_hsa011000.25755725
91AMPK signaling pathway_Homo sapiens_hsa041520.24207058
92Circadian entrainment_Homo sapiens_hsa047130.23849224
93Gastric acid secretion_Homo sapiens_hsa049710.23526218
94Pertussis_Homo sapiens_hsa051330.23018706
95Renin secretion_Homo sapiens_hsa049240.22628821
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19346408
97Fatty acid elongation_Homo sapiens_hsa000620.18292675
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.14292316
99Estrogen signaling pathway_Homo sapiens_hsa049150.14126343
100Protein digestion and absorption_Homo sapiens_hsa049740.13785006

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