C2ORF73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.80628289
2regulation of cilium movement (GO:0003352)7.42233889
3ventricular system development (GO:0021591)6.12681770
4intraciliary transport (GO:0042073)6.00964420
5cilium organization (GO:0044782)5.98929184
6left/right pattern formation (GO:0060972)5.98433592
7cilium assembly (GO:0042384)5.90324650
8left/right axis specification (GO:0070986)5.74240440
9sperm motility (GO:0030317)5.21177688
10microtubule bundle formation (GO:0001578)5.15038314
11protein localization to cilium (GO:0061512)5.09594403
12centriole assembly (GO:0098534)4.85559884
13cellular component assembly involved in morphogenesis (GO:0010927)4.74281367
14regulation of microtubule-based movement (GO:0060632)4.63749181
15acrosome reaction (GO:0007340)4.63121027
16cilium morphogenesis (GO:0060271)4.53633750
17sperm capacitation (GO:0048240)4.48433948
18fusion of sperm to egg plasma membrane (GO:0007342)4.41063143
19ethanol metabolic process (GO:0006067)4.23458264
20negative regulation of inclusion body assembly (GO:0090084)4.16002169
21cell projection assembly (GO:0030031)4.06081281
22microtubule-based movement (GO:0007018)4.02552967
23negative regulation of JUN kinase activity (GO:0043508)3.96642364
24primary alcohol catabolic process (GO:0034310)3.89729960
25microtubule depolymerization (GO:0007019)3.60143395
26spermatid development (GO:0007286)3.58105982
27centriole replication (GO:0007099)3.56013768
28protein polyglutamylation (GO:0018095)3.53967033
29one-carbon compound transport (GO:0019755)3.52862373
30negative regulation of immunoglobulin mediated immune response (GO:0002890)3.49863664
31negative regulation of B cell mediated immunity (GO:0002713)3.49863664
32ethanol oxidation (GO:0006069)3.49110070
33vitamin transmembrane transport (GO:0035461)3.45339885
34diterpenoid biosynthetic process (GO:0016102)3.43585407
35establishment of nucleus localization (GO:0040023)3.43283501
36microtubule polymerization or depolymerization (GO:0031109)3.31139049
37nucleoside diphosphate phosphorylation (GO:0006165)3.28662965
38plasma membrane fusion (GO:0045026)3.27801388
39phosphatidylethanolamine biosynthetic process (GO:0006646)3.23006934
40smoothened signaling pathway (GO:0007224)3.21405611
41brain morphogenesis (GO:0048854)3.16230415
42regulation of interleukin-5 production (GO:0032674)3.15052742
43protein targeting to Golgi (GO:0000042)3.07551666
44glutathione derivative metabolic process (GO:1901685)3.05442091
45glutathione derivative biosynthetic process (GO:1901687)3.05442091
46phosphatidylethanolamine metabolic process (GO:0046337)3.02256715
47phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.94413001
48establishment of apical/basal cell polarity (GO:0035089)2.93466971
49establishment of protein localization to Golgi (GO:0072600)2.93224486
50retinol metabolic process (GO:0042572)2.91526270
51regulation of Rac GTPase activity (GO:0032314)2.91429063
52retinal rod cell development (GO:0046548)2.90982122
53microtubule severing (GO:0051013)2.88524942
54response to xenobiotic stimulus (GO:0009410)2.87463533
55lateral ventricle development (GO:0021670)2.87335710
56multicellular organism reproduction (GO:0032504)2.86781324
57glomerular epithelial cell development (GO:0072310)2.85831794
58protein import into peroxisome matrix (GO:0016558)2.84155733
59lung epithelium development (GO:0060428)2.83191148
60tolerance induction (GO:0002507)2.81492919
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.81365249
62regulation of inclusion body assembly (GO:0090083)2.76991469
63calcium ion-dependent exocytosis (GO:0017156)2.75855915
64photoreceptor cell maintenance (GO:0045494)2.73027656
65cytoplasmic microtubule organization (GO:0031122)2.72960961
66pyrimidine-containing compound transmembrane transport (GO:0072531)2.69984063
67single fertilization (GO:0007338)2.67760955
68establishment of monopolar cell polarity (GO:0061162)2.65978114
69establishment or maintenance of monopolar cell polarity (GO:0061339)2.65978114
70retinoic acid metabolic process (GO:0042573)2.65635115
71nonmotile primary cilium assembly (GO:0035058)2.62747615
72phospholipid dephosphorylation (GO:0046839)2.62692122
73appendage development (GO:0048736)2.62530124
74limb development (GO:0060173)2.62530124
75peroxisome fission (GO:0016559)2.59091367
76synapsis (GO:0007129)2.58475752
77determination of left/right symmetry (GO:0007368)2.57206914
78phosphatidylinositol dephosphorylation (GO:0046856)2.57118358
79regulation of interleukin-13 production (GO:0032656)2.56350896
80negative regulation of T cell differentiation in thymus (GO:0033085)2.55548783
81organic cation transport (GO:0015695)2.54047899
82organelle assembly (GO:0070925)2.53792568
83protein localization to Golgi apparatus (GO:0034067)2.50987055
84mitochondrion degradation (GO:0000422)2.49673839
85terpenoid biosynthetic process (GO:0016114)2.48303384
86spinal cord motor neuron differentiation (GO:0021522)2.48248815
87determination of bilateral symmetry (GO:0009855)2.47091098
88primary alcohol metabolic process (GO:0034308)2.45582395
89exogenous drug catabolic process (GO:0042738)2.43881923
90regulation of secondary heart field cardioblast proliferation (GO:0003266)2.43114891
91regulation of cardioblast proliferation (GO:0003264)2.43114891
92spermatogenesis (GO:0007283)2.42855082
93dorsal/ventral neural tube patterning (GO:0021904)2.42069235
94specification of symmetry (GO:0009799)2.42021542
95axonemal dynein complex assembly (GO:0070286)16.6271919
96cilium or flagellum-dependent cell motility (GO:0001539)14.2478086
97cilium movement (GO:0003341)13.4153351
98epithelial cilium movement (GO:0003351)12.6275138
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.9274016
100motile cilium assembly (GO:0044458)11.2772155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22322009
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.20819950
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67508949
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45638236
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19749053
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.18377862
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12297425
8PIAS1_25552417_ChIP-Seq_VCAP_Human2.11221233
9GBX2_23144817_ChIP-Seq_PC3_Human2.10271344
10DROSHA_22980978_ChIP-Seq_HELA_Human2.00557139
11POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90042368
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87415518
13FUS_26573619_Chip-Seq_HEK293_Human1.79657367
14SMAD4_21799915_ChIP-Seq_A2780_Human1.74956101
15* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.74809006
16AR_21572438_ChIP-Seq_LNCaP_Human1.68344402
17TP53_18474530_ChIP-ChIP_U2OS_Human1.68102918
18STAT3_23295773_ChIP-Seq_U87_Human1.67818189
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63786499
20NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63413475
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60282498
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58232581
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.57533780
24IGF1R_20145208_ChIP-Seq_DFB_Human1.56039203
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55549071
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51924300
27AHR_22903824_ChIP-Seq_MCF-7_Human1.51786807
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49976389
29AR_25329375_ChIP-Seq_VCAP_Human1.49525592
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.48451612
31TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.45925193
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45050298
33CBP_20019798_ChIP-Seq_JUKART_Human1.45050298
34VDR_22108803_ChIP-Seq_LS180_Human1.44835832
35* P300_19829295_ChIP-Seq_ESCs_Human1.43978172
36ER_23166858_ChIP-Seq_MCF-7_Human1.43642721
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38164967
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36638556
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36122484
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34397201
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33830588
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33676183
43EZH2_22144423_ChIP-Seq_EOC_Human1.33239672
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.32558832
45BCAT_22108803_ChIP-Seq_LS180_Human1.32145885
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31807710
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31209010
48TCF4_22108803_ChIP-Seq_LS180_Human1.30412936
49TP63_23658742_ChIP-Seq_EP156T_Human1.29285317
50TCF4_23295773_ChIP-Seq_U87_Human1.28435221
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.28158294
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26009280
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25530827
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.25530827
55RUNX2_22187159_ChIP-Seq_PCA_Human1.24829656
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24644859
57TBL1_22424771_ChIP-Seq_293T_Human1.23629141
58ZNF274_21170338_ChIP-Seq_K562_Hela1.22699627
59PHF8_20622853_ChIP-Seq_HELA_Human1.22288162
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21731722
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21731722
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21512844
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21219845
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18888005
65CBP_21632823_ChIP-Seq_H3396_Human1.17717040
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16196675
67REST_21632747_ChIP-Seq_MESCs_Mouse1.15747470
68HNFA_21074721_ChIP-Seq_CACO-2_Human1.14520622
69* CDX2_22108803_ChIP-Seq_LS180_Human1.14063757
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.13270368
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12265214
72NFYB_21822215_ChIP-Seq_K562_Human1.12026316
73* SMRT_27268052_Chip-Seq_Bcells_Human1.10663358
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10273576
75NFYA_21822215_ChIP-Seq_K562_Human1.10206408
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09685276
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.09402888
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07902021
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07381501
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.07190975
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06753907
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.05612137
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04871428
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04395236
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.04310299
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.03721334
87AR_20517297_ChIP-Seq_VCAP_Human1.03424925
88TAF15_26573619_Chip-Seq_HEK293_Human1.03311412
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02019462
90* ETV1_20927104_ChIP-Seq_GIST48_Human1.01867064
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.00585552
92* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00505632
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99512159
94NCOR_22424771_ChIP-Seq_293T_Human0.98885819
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98756139
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98160345
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.96602069
98* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96448635
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95329893
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95211737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.53117532
2MP0003195_calcinosis4.08483411
3MP0003136_yellow_coat_color3.79942019
4MP0009780_abnormal_chondrocyte_physiolo3.66000719
5MP0005410_abnormal_fertilization3.39097749
6MP0001984_abnormal_olfaction3.34123572
7MP0008875_abnormal_xenobiotic_pharmacok3.14864633
8MP0004043_abnormal_pH_regulation2.94148623
9MP0003880_abnormal_central_pattern2.83558700
10MP0002132_abnormal_respiratory_system2.57961457
11MP0002160_abnormal_reproductive_system2.45192857
12MP0002277_abnormal_respiratory_mucosa2.33408056
13MP0000383_abnormal_hair_follicle2.15262961
14MP0004133_heterotaxia2.14164743
15MP0008877_abnormal_DNA_methylation2.08794535
16MP0003698_abnormal_male_reproductive2.05761933
17MP0002638_abnormal_pupillary_reflex1.97670243
18MP0001929_abnormal_gametogenesis1.93207109
19MP0004019_abnormal_vitamin_homeostasis1.91058531
20MP0009046_muscle_twitch1.84872727
21MP0005377_hearing/vestibular/ear_phenot1.74986522
22MP0003878_abnormal_ear_physiology1.74986522
23MP0010678_abnormal_skin_adnexa1.68391626
24MP0001765_abnormal_ion_homeostasis1.66997214
25MP0005646_abnormal_pituitary_gland1.62204546
26MP0008789_abnormal_olfactory_epithelium1.62167123
27MP0002876_abnormal_thyroid_physiology1.60879454
28MP0002822_catalepsy1.58649403
29MP0002928_abnormal_bile_duct1.55916241
30MP0000678_abnormal_parathyroid_gland1.55001086
31MP0002909_abnormal_adrenal_gland1.51868194
32MP0001485_abnormal_pinna_reflex1.51467552
33MP0002734_abnormal_mechanical_nocicepti1.49674594
34MP0005551_abnormal_eye_electrophysiolog1.43437406
35MP0005253_abnormal_eye_physiology1.41787057
36MP0002168_other_aberrant_phenotype1.41659490
37MP0003787_abnormal_imprinting1.38570998
38MP0005623_abnormal_meninges_morphology1.37295710
39MP0001944_abnormal_pancreas_morphology1.36454439
40MP0002282_abnormal_trachea_morphology1.36251156
41MP0003123_paternal_imprinting1.35984873
42MP0005248_abnormal_Harderian_gland1.33621149
43MP0005084_abnormal_gallbladder_morpholo1.31509735
44MP0004270_analgesia1.16427615
45MP0005636_abnormal_mineral_homeostasis1.15294207
46MP0005389_reproductive_system_phenotype1.15174865
47MP0000955_abnormal_spinal_cord1.14909747
48MP0005379_endocrine/exocrine_gland_phen1.13297487
49MP0005394_taste/olfaction_phenotype1.11840063
50MP0005499_abnormal_olfactory_system1.11840063
51MP0002837_dystrophic_cardiac_calcinosis1.11247857
52MP0000631_abnormal_neuroendocrine_gland1.10717636
53MP0006072_abnormal_retinal_apoptosis1.09404469
54MP0002249_abnormal_larynx_morphology1.08423194
55MP0001486_abnormal_startle_reflex1.07528866
56MP0009745_abnormal_behavioral_response1.06053333
57MP0004085_abnormal_heartbeat1.06015027
58MP0000026_abnormal_inner_ear1.05606152
59MP0000566_synostosis1.03495623
60MP0000013_abnormal_adipose_tissue1.02558526
61MP0005645_abnormal_hypothalamus_physiol1.01993076
62MP0005423_abnormal_somatic_nervous0.99881654
63MP0004885_abnormal_endolymph0.99593036
64MP0004859_abnormal_synaptic_plasticity0.98828594
65MP0002161_abnormal_fertility/fecundity0.98595942
66MP0005395_other_phenotype0.98339048
67MP0002139_abnormal_hepatobiliary_system0.97529714
68MP0001270_distended_abdomen0.97158958
69MP0002210_abnormal_sex_determination0.96833514
70MP0001502_abnormal_circadian_rhythm0.94801258
71MP0002272_abnormal_nervous_system0.93719631
72MP0002229_neurodegeneration0.92751482
73MP0001664_abnormal_digestion0.92134225
74MP0002735_abnormal_chemical_nociception0.91533488
75MP0002572_abnormal_emotion/affect_behav0.91172529
76MP0002295_abnormal_pulmonary_circulatio0.90143003
77MP0009379_abnormal_foot_pigmentation0.86545125
78MP0001963_abnormal_hearing_physiology0.86405200
79MP0000653_abnormal_sex_gland0.84530853
80MP0003122_maternal_imprinting0.83361464
81MP0005187_abnormal_penis_morphology0.80832130
82MP0003879_abnormal_hair_cell0.79860756
83MP0001145_abnormal_male_reproductive0.78645731
84MP0003656_abnormal_erythrocyte_physiolo0.78643333
85MP0008004_abnormal_stomach_pH0.78354217
86MP0001501_abnormal_sleep_pattern0.77879385
87MP0002067_abnormal_sensory_capabilities0.75069984
88MP0001970_abnormal_pain_threshold0.74405721
89MP0003633_abnormal_nervous_system0.72408807
90MP0003011_delayed_dark_adaptation0.71457679
91MP0002557_abnormal_social/conspecific_i0.71266799
92MP0003632_abnormal_nervous_system0.70776187
93MP0002064_seizures0.69900133
94MP0001324_abnormal_eye_pigmentation0.69333499
95MP0001756_abnormal_urination0.68718670
96MP0005195_abnormal_posterior_eye0.68537293
97MP0005391_vision/eye_phenotype0.67785027
98MP0005083_abnormal_biliary_tract0.64820058
99MP0002693_abnormal_pancreas_physiology0.64559362
100MP0003953_abnormal_hormone_level0.63067567

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.63937183
2Abnormal ciliary motility (HP:0012262)9.55501432
3Abnormal respiratory motile cilium morphology (HP:0005938)9.48436774
4Abnormal respiratory epithelium morphology (HP:0012253)9.48436774
5Absent/shortened dynein arms (HP:0200106)9.12296730
6Dynein arm defect of respiratory motile cilia (HP:0012255)9.12296730
7Rhinitis (HP:0012384)8.56690105
8Chronic bronchitis (HP:0004469)6.33961810
9Bronchiectasis (HP:0002110)5.96657898
10Nasal polyposis (HP:0100582)5.63054342
11Abnormality of the nasal mucosa (HP:0000433)4.58756056
12Pancreatic fibrosis (HP:0100732)3.93713065
13True hermaphroditism (HP:0010459)3.86998546
14Occipital encephalocele (HP:0002085)3.79418484
15Infertility (HP:0000789)3.77675739
16Nephronophthisis (HP:0000090)3.68181805
17Chronic sinusitis (HP:0011109)3.59276768
18Chronic hepatic failure (HP:0100626)3.46678759
19Pancreatic cysts (HP:0001737)3.36256502
20Molar tooth sign on MRI (HP:0002419)3.36078315
21Abnormality of midbrain morphology (HP:0002418)3.36078315
22Male infertility (HP:0003251)3.28327848
23Recurrent sinusitis (HP:0011108)3.24630819
24Bronchitis (HP:0012387)3.23939887
25Cystic liver disease (HP:0006706)3.19823725
26Atelectasis (HP:0100750)3.13686676
27Tubulointerstitial nephritis (HP:0001970)2.89402426
28Osteomalacia (HP:0002749)2.85376825
29Abnormality of the renal medulla (HP:0100957)2.85329799
30Hyperaldosteronism (HP:0000859)2.76588463
31Recurrent otitis media (HP:0000403)2.72292575
32Renal Fanconi syndrome (HP:0001994)2.64841809
33Abnormality of dentin (HP:0010299)2.63817900
34Abnormal drinking behavior (HP:0030082)2.63111747
35Polydipsia (HP:0001959)2.63111747
36Tubular atrophy (HP:0000092)2.52938688
37Postaxial foot polydactyly (HP:0001830)2.50174929
38Chronic otitis media (HP:0000389)2.44258468
39Hyperactive renin-angiotensin system (HP:0000841)2.42666034
40Medial flaring of the eyebrow (HP:0010747)2.37715889
41Abnormality of permanent molar morphology (HP:0011071)2.36849084
42Abnormality of the dental root (HP:0006486)2.36849084
43Taurodontia (HP:0000679)2.36849084
44Male pseudohermaphroditism (HP:0000037)2.26963849
45Abnormality of molar (HP:0011077)2.25263413
46Abnormality of molar morphology (HP:0011070)2.25263413
47Congenital hepatic fibrosis (HP:0002612)2.18456209
48Abnormality of the dental pulp (HP:0006479)2.16863784
49Anencephaly (HP:0002323)2.13387251
50Proximal tubulopathy (HP:0000114)2.11419703
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.11155662
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.06979993
53Furrowed tongue (HP:0000221)2.03991156
54Abnormality of renal resorption (HP:0011038)2.03024187
55Bell-shaped thorax (HP:0001591)2.00761921
56Oligodactyly (hands) (HP:0001180)2.00634694
57Congenital primary aphakia (HP:0007707)2.00083968
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4671078
59Sclerocornea (HP:0000647)1.98146364
60Gait imbalance (HP:0002141)1.98062070
61Hyponatremia (HP:0002902)1.96073053
62Increased circulating renin level (HP:0000848)1.90958285
63Decreased circulating renin level (HP:0003351)1.88895976
64Tubulointerstitial abnormality (HP:0001969)1.86088571
65Postaxial hand polydactyly (HP:0001162)1.84600511
66Hyperphosphaturia (HP:0003109)1.81679178
67Oculomotor apraxia (HP:0000657)1.77170454
68Stage 5 chronic kidney disease (HP:0003774)1.75604982
69Abnormality of renin-angiotensin system (HP:0000847)1.74097228
70Fetal akinesia sequence (HP:0001989)1.73570422
71Nephrogenic diabetes insipidus (HP:0009806)1.73094272
72Buphthalmos (HP:0000557)1.71009736
73Polyuria (HP:0000103)1.68532259
74Brushfield spots (HP:0001088)1.68473422
75Hypokalemia (HP:0002900)1.67204668
76Hyperkalemia (HP:0002153)1.65709269
77Abnormality of the renal cortex (HP:0011035)1.65581653
78Abnormality of renal excretion (HP:0011036)1.60263279
79Aplasia/Hypoplasia of the lens (HP:0008063)1.60010009
80Cheilitis (HP:0100825)1.58425992
81Abnormality of vitamin metabolism (HP:0100508)1.56641896
82Abnormality of sodium homeostasis (HP:0010931)1.56559142
83Median cleft lip (HP:0000161)1.54285149
84Severe visual impairment (HP:0001141)1.51627803
85Preaxial hand polydactyly (HP:0001177)1.51590066
86Abnormality of potassium homeostasis (HP:0011042)1.51506706
87Intestinal atresia (HP:0011100)1.50046011
88Abnormal urine output (HP:0012590)1.46189265
89Poor coordination (HP:0002370)1.45439756
90Genital tract atresia (HP:0001827)1.44255295
91Abnormal urine phosphate concentration (HP:0012599)1.42214338
92Abnormality of macular pigmentation (HP:0008002)1.41789679
93Nephropathy (HP:0000112)1.41129591
94Rickets (HP:0002748)1.37673847
95Large for gestational age (HP:0001520)1.37340224
96Vaginal atresia (HP:0000148)1.35444982
97Oligodactyly (HP:0012165)1.34610237
98Retinitis pigmentosa (HP:0000510)1.33594916
99Hyperphosphatemia (HP:0002905)1.31684949
100Gastrointestinal atresia (HP:0002589)1.30708632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.72367744
2MST43.09279165
3EPHA32.91367890
4PTK2B2.31914863
5FRK2.21564215
6NTRK32.12481616
7STK382.11132072
8PINK12.04501378
9PLK22.00098321
10MAPK1510.3699271
11ERBB31.97472313
12STK38L1.92276399
13EPHA21.86015459
14TNIK1.76981808
15STK241.51456415
16LATS11.49041787
17STK31.35226004
18TRPM71.33693829
19BCR1.24303142
20INSRR1.23035515
21MAP3K21.21403499
22TESK11.17552282
23ACVR1B1.10433048
24CAMKK21.07512491
25CSNK1G21.05438433
26PLK41.05431592
27MAP4K20.98675323
28RIPK10.93237795
29PRKCI0.89884779
30MAP2K60.89629194
31MAPKAPK30.87925539
32UHMK10.86884920
33TSSK60.85970819
34GRK10.81399828
35CSNK1G30.76881799
36EPHB10.76719520
37PAK30.75102806
38STK390.74097402
39TTK0.73367009
40CSNK1G10.71587868
41STK160.70719904
42WNK30.68907442
43MARK30.67335084
44NTRK20.65758052
45NEK90.63410121
46CSNK1A1L0.60802920
47PHKG20.57802095
48PHKG10.57802095
49WNK40.57694726
50OXSR10.56780696
51CAMK1G0.55734416
52PRKCG0.55525302
53NLK0.54434248
54TLK10.54432448
55BMPR1B0.53193139
56BMPR20.52699722
57VRK10.51153134
58CDK90.50891992
59NEK60.50119412
60PRKCE0.49965010
61MARK20.49410099
62CDK30.48700144
63DAPK20.48126465
64MAP2K70.46526751
65CDK80.46187454
66MAP3K40.46160961
67LIMK10.45731161
68ERBB20.45316755
69AKT30.44693123
70PRKCZ0.44668323
71SGK2230.44169891
72SGK4940.44169891
73STK40.42216316
74SGK10.42199744
75DDR20.41454865
76BRSK20.40802407
77FGFR20.39208707
78CAMKK10.39032604
79CAMK2A0.37875043
80ERBB40.37504400
81PRKG10.37174357
82NME10.36313647
83SGK20.35769429
84PRKACA0.35033132
85MST1R0.34846731
86MUSK0.34515605
87ADRBK20.33598248
88MET0.33205911
89CSNK1A10.33094239
90FER0.32433551
91PRKAA10.31592527
92ROCK10.31220912
93YES10.31115631
94CAMK2G0.31092587
95PRKAA20.30873491
96ADRBK10.30288088
97IRAK10.29958862
98MAP3K70.29652638
99CASK0.27035957
100ROCK20.25633550

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.62414727
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.18475588
3Chemical carcinogenesis_Homo sapiens_hsa052043.06797664
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.02648352
5Phenylalanine metabolism_Homo sapiens_hsa003602.80556059
6Histidine metabolism_Homo sapiens_hsa003402.59157027
7Glutathione metabolism_Homo sapiens_hsa004802.55677707
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48511165
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36842994
10Huntingtons disease_Homo sapiens_hsa050162.31314778
11Tyrosine metabolism_Homo sapiens_hsa003502.25658899
12beta-Alanine metabolism_Homo sapiens_hsa004102.16414588
13Peroxisome_Homo sapiens_hsa041462.10696802
14Retinol metabolism_Homo sapiens_hsa008302.03349385
15ABC transporters_Homo sapiens_hsa020101.88843462
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.75412922
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57363696
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53449188
19Fatty acid degradation_Homo sapiens_hsa000711.46328404
20Circadian rhythm_Homo sapiens_hsa047101.44770060
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43051684
22Protein export_Homo sapiens_hsa030601.42053060
23Arginine biosynthesis_Homo sapiens_hsa002201.38773488
24Linoleic acid metabolism_Homo sapiens_hsa005911.37536751
25Butanoate metabolism_Homo sapiens_hsa006501.37259927
26Nitrogen metabolism_Homo sapiens_hsa009101.36538511
27Olfactory transduction_Homo sapiens_hsa047401.35657091
28Tryptophan metabolism_Homo sapiens_hsa003801.34321927
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31267528
30Salivary secretion_Homo sapiens_hsa049701.20902358
31Hedgehog signaling pathway_Homo sapiens_hsa043401.19870174
32Vitamin B6 metabolism_Homo sapiens_hsa007501.18239864
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.17233335
34Arachidonic acid metabolism_Homo sapiens_hsa005901.16217946
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12241983
36Nicotine addiction_Homo sapiens_hsa050331.09811108
37Phototransduction_Homo sapiens_hsa047441.09003841
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08976757
39Insulin secretion_Homo sapiens_hsa049111.06565559
40Ether lipid metabolism_Homo sapiens_hsa005651.05533961
41Caffeine metabolism_Homo sapiens_hsa002321.04610662
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04084650
43Cocaine addiction_Homo sapiens_hsa050301.02726487
44Sphingolipid metabolism_Homo sapiens_hsa006001.01895452
45Inositol phosphate metabolism_Homo sapiens_hsa005621.01812306
46Collecting duct acid secretion_Homo sapiens_hsa049660.99543572
47Tight junction_Homo sapiens_hsa045300.97385599
48Folate biosynthesis_Homo sapiens_hsa007900.91357145
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90531322
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.88702458
51Arginine and proline metabolism_Homo sapiens_hsa003300.86720196
52Regulation of autophagy_Homo sapiens_hsa041400.82978465
53Amphetamine addiction_Homo sapiens_hsa050310.82334225
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80675719
55Synaptic vesicle cycle_Homo sapiens_hsa047210.79104134
56Fatty acid elongation_Homo sapiens_hsa000620.78754917
57Circadian entrainment_Homo sapiens_hsa047130.77891280
58Taste transduction_Homo sapiens_hsa047420.75532642
59cAMP signaling pathway_Homo sapiens_hsa040240.75070055
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74412432
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72428376
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71901774
63Fatty acid biosynthesis_Homo sapiens_hsa000610.71026053
64Serotonergic synapse_Homo sapiens_hsa047260.70040609
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69440048
66Glutamatergic synapse_Homo sapiens_hsa047240.66909566
67Metabolic pathways_Homo sapiens_hsa011000.66682614
68Dorso-ventral axis formation_Homo sapiens_hsa043200.65651637
69Axon guidance_Homo sapiens_hsa043600.65603752
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64036919
71Renin secretion_Homo sapiens_hsa049240.64034442
72Calcium signaling pathway_Homo sapiens_hsa040200.62531097
73Oxidative phosphorylation_Homo sapiens_hsa001900.61118168
74PPAR signaling pathway_Homo sapiens_hsa033200.59934907
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59359006
76Propanoate metabolism_Homo sapiens_hsa006400.59014731
77Cardiac muscle contraction_Homo sapiens_hsa042600.54140218
78Pancreatic secretion_Homo sapiens_hsa049720.52386404
79Glycerolipid metabolism_Homo sapiens_hsa005610.51240810
80Basal cell carcinoma_Homo sapiens_hsa052170.50096935
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49907204
82Mineral absorption_Homo sapiens_hsa049780.49106443
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47673277
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46537511
85Fatty acid metabolism_Homo sapiens_hsa012120.45549003
86Gap junction_Homo sapiens_hsa045400.45250802
87Bile secretion_Homo sapiens_hsa049760.44217655
88Morphine addiction_Homo sapiens_hsa050320.43618073
89Gastric acid secretion_Homo sapiens_hsa049710.42110616
90GABAergic synapse_Homo sapiens_hsa047270.42008691
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41887581
92Thyroid hormone synthesis_Homo sapiens_hsa049180.41460603
93Notch signaling pathway_Homo sapiens_hsa043300.39695407
94N-Glycan biosynthesis_Homo sapiens_hsa005100.38742245
95Alzheimers disease_Homo sapiens_hsa050100.38202172
96Parkinsons disease_Homo sapiens_hsa050120.37993783
97Starch and sucrose metabolism_Homo sapiens_hsa005000.37579741
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37099472
99Purine metabolism_Homo sapiens_hsa002300.37033132
100Ovarian steroidogenesis_Homo sapiens_hsa049130.33352646

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