C2ORF78

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)9.72242254
2retrograde transport, vesicle recycling within Golgi (GO:0000301)9.47482850
3chromosome condensation (GO:0030261)8.91231259
4microtubule depolymerization (GO:0007019)8.51129739
5DNA packaging (GO:0006323)8.48778751
6protein polyglutamylation (GO:0018095)8.31274658
7microtubule polymerization or depolymerization (GO:0031109)8.07662720
8plasma membrane fusion (GO:0045026)7.86239286
9rRNA methylation (GO:0031167)7.78578202
10centriole replication (GO:0007099)7.67175413
11sperm capacitation (GO:0048240)7.54043626
12protein localization to Golgi apparatus (GO:0034067)7.31980640
13seminiferous tubule development (GO:0072520)7.27443690
14spermatid development (GO:0007286)7.26527796
15regulation of centriole replication (GO:0046599)6.98225584
16spermatogenesis (GO:0007283)6.78166090
17sperm-egg recognition (GO:0035036)6.76158879
18male gamete generation (GO:0048232)6.76025971
19centriole assembly (GO:0098534)6.72965927
20single strand break repair (GO:0000012)6.72836584
21rRNA modification (GO:0000154)6.55812376
22glomerular visceral epithelial cell development (GO:0072015)6.55625031
23spermatid nucleus differentiation (GO:0007289)6.32365659
24multicellular organism reproduction (GO:0032504)6.25101343
25gamete generation (GO:0007276)6.24332458
26binding of sperm to zona pellucida (GO:0007339)6.13016911
27glomerular epithelial cell development (GO:0072310)6.02268843
28calcium ion-dependent exocytosis (GO:0017156)5.95273210
29axonemal dynein complex assembly (GO:0070286)5.92987049
30phosphatidylethanolamine biosynthetic process (GO:0006646)5.80398043
31nuclear pore complex assembly (GO:0051292)5.76414971
32reproduction (GO:0000003)5.71834417
33cell-cell recognition (GO:0009988)5.52476669
34RNA destabilization (GO:0050779)5.47745624
35microtubule nucleation (GO:0007020)5.46627830
36microtubule severing (GO:0051013)5.41001607
37single fertilization (GO:0007338)5.37523707
38phosphatidylethanolamine metabolic process (GO:0046337)5.36642641
39negative regulation of inclusion body assembly (GO:0090084)5.16127804
40response to pheromone (GO:0019236)5.15488006
41cilium or flagellum-dependent cell motility (GO:0001539)5.15090316
42motile cilium assembly (GO:0044458)5.10472431
43sexual reproduction (GO:0019953)5.08042408
44fertilization (GO:0009566)4.98528791
45multicellular organismal reproductive process (GO:0048609)4.97301311
46regulation of cilium movement (GO:0003352)4.79234424
47epithelial cilium movement (GO:0003351)4.74601458
48multicellular organismal movement (GO:0050879)4.62946622
49musculoskeletal movement (GO:0050881)4.62946622
50nuclear pore organization (GO:0006999)4.42789323
51pore complex assembly (GO:0046931)4.40379587
52positive regulation of Rab GTPase activity (GO:0032851)4.37427006
53regulation of Rab GTPase activity (GO:0032313)4.37427006
54nucleus organization (GO:0006997)4.34940283
55germ cell development (GO:0007281)4.34118076
56cell wall macromolecule catabolic process (GO:0016998)4.29482909
57cilium movement (GO:0003341)4.14237672
58cellular process involved in reproduction in multicellular organism (GO:0022412)4.10777802
59intra-Golgi vesicle-mediated transport (GO:0006891)4.05548691
60cell wall macromolecule metabolic process (GO:0044036)4.04161376
61glycerol ether metabolic process (GO:0006662)3.96594259
62ether metabolic process (GO:0018904)3.65523248
63regulation of inclusion body assembly (GO:0090083)3.56390076
64membrane protein intracellular domain proteolysis (GO:0031293)3.54868143
65tRNA methylation (GO:0030488)3.51556712
66chromatin silencing (GO:0006342)3.44350154
67axoneme assembly (GO:0035082)3.40808101
68cellular ketone body metabolic process (GO:0046950)3.38993794
69regulation of transcription involved in cell fate commitment (GO:0060850)3.38679327
70ventricular system development (GO:0021591)3.36246475
71RNA localization (GO:0006403)3.32448271
72piRNA metabolic process (GO:0034587)3.31911140
73protein depolymerization (GO:0051261)3.26509308
74male meiosis I (GO:0007141)3.16090059
75regulation of centrosome duplication (GO:0010824)3.13175029
76RNA methylation (GO:0001510)3.13101399
77regulation of meiosis I (GO:0060631)3.04336091
78positive regulation of guanylate cyclase activity (GO:0031284)3.03662066
79receptor recycling (GO:0001881)3.00172615
80DNA methylation involved in gamete generation (GO:0043046)2.99813229
81Golgi to endosome transport (GO:0006895)2.98162915
82ketone body metabolic process (GO:1902224)2.97239844
83male meiosis (GO:0007140)2.94174074
84multicellular organismal development (GO:0007275)2.93651291
85histone H3-K9 demethylation (GO:0033169)2.93588334
86centrosome duplication (GO:0051298)2.93039256
87vesicle transport along microtubule (GO:0047496)2.91990709
88protein K48-linked deubiquitination (GO:0071108)2.85878606
89organic cation transport (GO:0015695)2.84689997
90DNA conformation change (GO:0071103)2.81109633
91regulation of microtubule-based movement (GO:0060632)2.80801540
92acrosome assembly (GO:0001675)2.78476211
93homeostasis of number of cells within a tissue (GO:0048873)2.78145291
94regulation of guanylate cyclase activity (GO:0031282)2.77251701
95cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.76725297
96mitotic G1 DNA damage checkpoint (GO:0031571)2.76109247
97sperm motility (GO:0030317)11.8481105
98fusion of sperm to egg plasma membrane (GO:0007342)10.4014042
99acrosome reaction (GO:0007340)10.2144715
100protein targeting to Golgi (GO:0000042)10.1300506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.62708072
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.81500719
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.43682694
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.24191880
5FUS_26573619_Chip-Seq_HEK293_Human2.64394302
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62798547
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.62798547
8CBP_20019798_ChIP-Seq_JUKART_Human2.42448995
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.42448995
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32603767
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17730502
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15059287
13EZH2_22144423_ChIP-Seq_EOC_Human2.01786772
14RAC3_21632823_ChIP-Seq_H3396_Human1.84838811
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81817967
16DROSHA_22980978_ChIP-Seq_HELA_Human1.78929910
17ER_23166858_ChIP-Seq_MCF-7_Human1.76647974
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.75693437
19SMAD4_21741376_ChIP-Seq_EPCs_Human1.69981805
20CBX2_22325352_ChIP-Seq_293T-Rex_Human1.67778761
21ARNT_22903824_ChIP-Seq_MCF-7_Human1.66821986
22ERA_21632823_ChIP-Seq_H3396_Human1.63759342
23MYC_19829295_ChIP-Seq_ESCs_Human1.62308348
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62139625
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.60936375
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60440970
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58707556
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58576642
29RBPJ_21746931_ChIP-Seq_IB4_Human1.58190917
30HNFA_21074721_ChIP-Seq_CACO-2_Human1.56295946
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.53680482
32ETV1_20927104_ChIP-Seq_GIST48_Human1.51778962
33P300_19829295_ChIP-Seq_ESCs_Human1.51434865
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.50656701
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.49430360
36TAF2_19829295_ChIP-Seq_ESCs_Human1.47311787
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.46274416
38NFYB_21822215_ChIP-Seq_K562_Human1.46079710
39TP53_18474530_ChIP-ChIP_U2OS_Human1.43502688
40NANOG_20526341_ChIP-Seq_ESCs_Human1.42741502
41TBL1_22424771_ChIP-Seq_293T_Human1.42306899
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41234408
43AR_25329375_ChIP-Seq_VCAP_Human1.40014553
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.39462440
45PHF8_20622853_ChIP-Seq_HELA_Human1.36556527
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36511400
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36261481
48ERG_20517297_ChIP-Seq_VCAP_Human1.33819387
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33224702
50PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.32327245
51ZNF274_21170338_ChIP-Seq_K562_Hela1.30925349
52CTCF_27219007_Chip-Seq_Bcells_Human1.30550035
53STAT3_23295773_ChIP-Seq_U87_Human1.30221880
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30098876
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29767394
56CEBPB_22108803_ChIP-Seq_LS180_Human1.28154897
57SMAD3_21741376_ChIP-Seq_ESCs_Human1.27866590
58OCT4_20526341_ChIP-Seq_ESCs_Human1.26703891
59GATA6_21074721_ChIP-Seq_CACO-2_Human1.26082363
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25780160
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25257428
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24451162
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24333406
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.22229651
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21548748
66SMAD4_21799915_ChIP-Seq_A2780_Human1.21251265
67TP63_22573176_ChIP-Seq_HFKS_Human1.18738554
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18168518
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18128360
70SMC4_20622854_ChIP-Seq_HELA_Human1.16979811
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16637688
72NFYA_21822215_ChIP-Seq_K562_Human1.15666629
73CTCF_20526341_ChIP-Seq_ESCs_Human1.15449594
74* ELF1_20517297_ChIP-Seq_JURKAT_Human1.14073402
75VDR_22108803_ChIP-Seq_LS180_Human1.13703411
76SOX2_22085726_ChIP-Seq_NPCs_Mouse1.12134462
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.11746810
78BCL6_27268052_Chip-Seq_Bcells_Human1.11599899
79RUNX2_22187159_ChIP-Seq_PCA_Human1.11591021
80KDM2B_26808549_Chip-Seq_REH_Human1.08935115
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07525041
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07350647
83TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07126072
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.06884836
85GBX2_23144817_ChIP-Seq_PC3_Human1.06761467
86BCOR_27268052_Chip-Seq_Bcells_Human1.03913258
87E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02471995
88SOX2_19829295_ChIP-Seq_ESCs_Human1.02399720
89NANOG_19829295_ChIP-Seq_ESCs_Human1.02399720
90SALL4_22934838_ChIP-ChIP_CD34+_Human1.01901403
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01804956
92TAF15_26573619_Chip-Seq_HEK293_Human1.01096699
93PHF8_20622854_ChIP-Seq_HELA_Human1.00765717
94KLF5_25053715_ChIP-Seq_YYC3_Human1.00275182
95P68_20966046_ChIP-Seq_HELA_Human1.00021181
96CJUN_26792858_Chip-Seq_BT549_Human0.98512248
97* YY1_22570637_ChIP-Seq_MALME-3M_Human0.98235236
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.98012444
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97798696
100E2F1_20622854_ChIP-Seq_HELA_Human0.97111541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology6.51273684
2MP0005377_hearing/vestibular/ear_phenot6.51273684
3MP0005670_abnormal_white_adipose4.45799462
4MP0003698_abnormal_male_reproductive4.18276828
5MP0001929_abnormal_gametogenesis3.77953366
6MP0001348_abnormal_lacrimal_gland3.53046731
7MP0005451_abnormal_body_composition2.78369113
8MP0003646_muscle_fatigue2.51855500
9MP0001485_abnormal_pinna_reflex2.35189571
10MP0002161_abnormal_fertility/fecundity2.28313075
11MP0003718_maternal_effect2.22763691
12MP0003879_abnormal_hair_cell2.14281854
13MP0005310_abnormal_salivary_gland2.10041026
14MP0005379_endocrine/exocrine_gland_phen2.00924773
15MP0005410_abnormal_fertilization10.9282057
16MP0001486_abnormal_startle_reflex1.95500300
17MP0002210_abnormal_sex_determination1.87544591
18MP0004742_abnormal_vestibular_system1.78207160
19MP0003011_delayed_dark_adaptation1.70259663
20MP0001145_abnormal_male_reproductive1.49958295
21MP0000678_abnormal_parathyroid_gland1.49759232
22MP0005423_abnormal_somatic_nervous1.46844581
23MP0000653_abnormal_sex_gland1.38493857
24MP0008877_abnormal_DNA_methylation1.33713882
25MP0001963_abnormal_hearing_physiology1.31305079
26MP0001984_abnormal_olfaction1.30621307
27MP0002282_abnormal_trachea_morphology1.26226642
28MP0002132_abnormal_respiratory_system1.24023156
29MP0009115_abnormal_fat_cell1.21419865
30MP0004859_abnormal_synaptic_plasticity1.17733761
31MP0005551_abnormal_eye_electrophysiolog1.16314158
32MP0009697_abnormal_copulation1.13132354
33MP0002138_abnormal_hepatobiliary_system1.12114859
34MP0001765_abnormal_ion_homeostasis1.09513194
35MP0005253_abnormal_eye_physiology1.05199624
36MP0004510_myositis1.02283557
37MP0005666_abnormal_adipose_tissue0.99216828
38MP0000026_abnormal_inner_ear0.99050410
39MP0009053_abnormal_anal_canal0.94533294
40MP0005395_other_phenotype0.92922593
41MP0008995_early_reproductive_senescence0.92031710
42MP0004233_abnormal_muscle_weight0.91029124
43MP0005167_abnormal_blood-brain_barrier0.89162041
44MP0002229_neurodegeneration0.85150717
45MP0005083_abnormal_biliary_tract0.83132629
46MP0002067_abnormal_sensory_capabilities0.80822731
47MP0001968_abnormal_touch/_nociception0.80017240
48MP0002249_abnormal_larynx_morphology0.79011068
49MP0005645_abnormal_hypothalamus_physiol0.75238414
50MP0000955_abnormal_spinal_cord0.74699021
51MP0002735_abnormal_chemical_nociception0.74509372
52MP0005248_abnormal_Harderian_gland0.73467317
53MP0002234_abnormal_pharynx_morphology0.71166081
54MP0000534_abnormal_ureter_morphology0.70327336
55MP0000230_abnormal_systemic_arterial0.70290070
56MP0005375_adipose_tissue_phenotype0.67864441
57MP0002127_abnormal_cardiovascular_syste0.67644610
58MP0003077_abnormal_cell_cycle0.65840492
59MP0001545_abnormal_hematopoietic_system0.64189348
60MP0005397_hematopoietic_system_phenotyp0.64189348
61MP0004084_abnormal_cardiac_muscle0.64152124
62MP0002557_abnormal_social/conspecific_i0.62862118
63MP0005332_abnormal_amino_acid0.62630372
64MP0002572_abnormal_emotion/affect_behav0.62206004
65MP0004085_abnormal_heartbeat0.61595793
66MP0010329_abnormal_lipoprotein_level0.60095356
67MP0004036_abnormal_muscle_relaxation0.59963265
68MP0010307_abnormal_tumor_latency0.58226436
69MP0002928_abnormal_bile_duct0.58197884
70MP0005408_hypopigmentation0.57155311
71MP0005636_abnormal_mineral_homeostasis0.55935217
72MP0008569_lethality_at_weaning0.54787963
73MP0002733_abnormal_thermal_nociception0.54222179
74MP0005084_abnormal_gallbladder_morpholo0.53470084
75MP0003137_abnormal_impulse_conducting0.52412668
76MP0001501_abnormal_sleep_pattern0.52383503
77MP0004782_abnormal_surfactant_physiolog0.49818631
78MP0001440_abnormal_grooming_behavior0.47882207
79MP0005391_vision/eye_phenotype0.45750216
80MP0000003_abnormal_adipose_tissue0.45205745
81MP0001666_abnormal_nutrient_absorption0.43866865
82MP0005535_abnormal_body_temperature0.43840706
83MP0008961_abnormal_basal_metabolism0.43824531
84MP0004957_abnormal_blastocyst_morpholog0.42874690
85MP0002272_abnormal_nervous_system0.42061745
86MP0005595_abnormal_vascular_smooth0.41783593
87MP0002136_abnormal_kidney_physiology0.39870043
88MP0003631_nervous_system_phenotype0.38511371
89MP0003329_amyloid_beta_deposits0.38165422
90MP0009745_abnormal_behavioral_response0.37000217
91MP0003633_abnormal_nervous_system0.35440789
92MP0001905_abnormal_dopamine_level0.35431735
93MP0002254_reproductive_system_inflammat0.35107133
94MP0002269_muscular_atrophy0.34508809
95MP0009643_abnormal_urine_homeostasis0.33287039
96MP0002184_abnormal_innervation0.33113385
97MP0001970_abnormal_pain_threshold0.33110584
98MP0009278_abnormal_bone_marrow0.32083589
99MP0002734_abnormal_mechanical_nocicepti0.31427343
100MP0000049_abnormal_middle_ear0.30382997

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)7.88931520
2Chronic hepatic failure (HP:0100626)7.47072483
3Severe visual impairment (HP:0001141)6.37450779
4Asymmetric septal hypertrophy (HP:0001670)6.31806426
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.28568063
6Absent/shortened dynein arms (HP:0200106)6.28568063
7Cone-rod dystrophy (HP:0000548)5.43553555
8Menstrual irregularities (HP:0000858)4.76645546
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.70266901
10Male infertility (HP:0003251)4.67255090
11Hypoalphalipoproteinemia (HP:0003233)4.63691997
12Abnormal respiratory motile cilium physiology (HP:0012261)4.49952457
13Nasal polyposis (HP:0100582)4.46257884
14Abnormal ciliary motility (HP:0012262)4.44372766
15Progressive sensorineural hearing impairment (HP:0000408)4.37568058
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.37050962
17Resting tremor (HP:0002322)4.31117569
18Hyperkalemia (HP:0002153)4.30797826
19Abnormality of macular pigmentation (HP:0008002)4.28269615
20Amelogenesis imperfecta (HP:0000705)4.20903000
21Abnormality of dental color (HP:0011073)3.97712092
22Attenuation of retinal blood vessels (HP:0007843)3.96941456
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.96107601
24Abnormal respiratory epithelium morphology (HP:0012253)3.95426733
25Abnormal respiratory motile cilium morphology (HP:0005938)3.95426733
26Renovascular hypertension (HP:0100817)3.94395716
27Bony spicule pigmentary retinopathy (HP:0007737)3.88614685
28Hypoplasia of the thymus (HP:0000778)3.76796032
29Infertility (HP:0000789)3.69550937
30Abnormality of the nasal mucosa (HP:0000433)3.63544220
31Tubulointerstitial abnormality (HP:0001969)3.56676653
32Truncal obesity (HP:0001956)3.56106869
33Insulin-resistant diabetes mellitus (HP:0000831)3.56077364
34Stage 5 chronic kidney disease (HP:0003774)3.55243541
35Progressive cerebellar ataxia (HP:0002073)3.45958626
36Portal hypertension (HP:0001409)3.42952122
37Impulsivity (HP:0100710)3.27784198
38Subcapsular cataract (HP:0000523)3.17382466
39Abnormality of the hepatic vasculature (HP:0006707)3.16935214
40Focal segmental glomerulosclerosis (HP:0000097)3.10261474
41Postural instability (HP:0002172)3.07632366
42Hyperuricemia (HP:0002149)2.97221173
43Increased purine levels (HP:0004368)2.97221173
44Intellectual disability, moderate (HP:0002342)2.92264609
45Nephronophthisis (HP:0000090)2.91394417
46Progressive hearing impairment (HP:0001730)2.87356302
47Potter facies (HP:0002009)2.72570613
48Facial shape deformation (HP:0011334)2.72570613
49Enlarged epiphyses (HP:0010580)2.63321396
50Chronic bronchitis (HP:0004469)2.62130200
51Rhinitis (HP:0012384)2.61139744
52Abnormal spermatogenesis (HP:0008669)2.55863392
53Abnormality of the renal medulla (HP:0100957)2.55484289
54Glomerulosclerosis (HP:0000096)2.52136407
55Abnormal albumin level (HP:0012116)2.51640759
56Hypoalbuminemia (HP:0003073)2.51640759
57Bell-shaped thorax (HP:0001591)2.47928552
58Hypolipoproteinemia (HP:0010981)2.46215714
59Abnormality of the costochondral junction (HP:0000919)2.39538978
60Abnormal drinking behavior (HP:0030082)2.31601973
61Polydipsia (HP:0001959)2.31601973
62Osteomalacia (HP:0002749)2.29115194
63Abnormal urine output (HP:0012590)2.25168627
64Abnormality of potassium homeostasis (HP:0011042)2.24117825
65Abnormal rod and cone electroretinograms (HP:0008323)2.23962103
66Ventricular tachycardia (HP:0004756)2.23268221
67Myokymia (HP:0002411)2.18019550
68Generalized aminoaciduria (HP:0002909)2.17668137
69Sandal gap (HP:0001852)2.17140713
70Hypoplastic ischia (HP:0003175)2.11573966
71Abnormality of purine metabolism (HP:0004352)2.08961136
72Recurrent pneumonia (HP:0006532)2.03702474
73Insulin resistance (HP:0000855)2.02224308
74Bilateral sensorineural hearing impairment (HP:0008619)2.00620667
75Tubular atrophy (HP:0000092)1.98218128
76Abnormality of renal excretion (HP:0011036)1.96994459
77Abnormality of the ischium (HP:0003174)1.93474272
78Bronchiectasis (HP:0002110)1.89942580
79Hypophosphatemic rickets (HP:0004912)1.89826065
80Polyuria (HP:0000103)1.87713964
81Gingivitis (HP:0000230)1.86728183
82Upper limb muscle weakness (HP:0003484)1.86012895
83Optic nerve hypoplasia (HP:0000609)1.84316358
84Bradycardia (HP:0001662)1.83286089
85Convex nasal ridge (HP:0000444)1.83192500
86Flattened epiphyses (HP:0003071)1.82420663
87Obsessive-compulsive behavior (HP:0000722)1.82312837
88Azoospermia (HP:0000027)1.81059079
89Congenital sensorineural hearing impairment (HP:0008527)1.80623286
90Hypergonadotropic hypogonadism (HP:0000815)1.78337681
91Polar cataract (HP:0010696)1.75981355
92Acanthosis nigricans (HP:0000956)1.75666540
93Growth hormone deficiency (HP:0000824)1.74586726
94Renal Fanconi syndrome (HP:0001994)1.74559574
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73729803
96Photophobia (HP:0000613)1.72922116
97Horizontal nystagmus (HP:0000666)1.72450590
98Decreased central vision (HP:0007663)1.69337398
99Hyponatremia (HP:0002902)1.67903255
100Pendular nystagmus (HP:0012043)1.67797649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.47654090
2BRD45.21883102
3PLK23.99810245
4PNCK3.52954277
5TESK13.12339441
6PIK3CG3.04046073
7CAMK1G2.63830493
8TYRO32.39658681
9MAP4K22.32733879
10DDR22.29439826
11PLK410.4195711
12STK38L1.89382306
13STK381.87799973
14PRKD31.77328155
15CDK121.61564099
16NEK61.57916587
17PDK11.48648870
18PDPK11.34584198
19WNK11.27897651
20PTK2B1.23857355
21MST1R1.19088904
22MAPK151.18581382
23TIE11.11023080
24DYRK1B0.99031932
25CAMK1D0.98480776
26AKT30.90690924
27CDK70.77966709
28SIK20.76902213
29MAP3K110.71829516
30PRKG20.70083423
31KSR20.65736700
32BRAF0.63832965
33MAP3K90.63489677
34CAMK10.56652832
35BRSK10.53473498
36MARK10.52601678
37LATS20.50405210
38CDK30.49807965
39LATS10.49579301
40NTRK30.48145681
41PRKG10.47782657
42MAP2K20.44581913
43PRKAA20.44357691
44BMPR1B0.39985125
45BRSK20.38511504
46CDK10.36634110
47SGK2230.36069798
48SGK4940.36069798
49MAPK10.35114844
50CDK20.34916558
51RPS6KA20.34024615
52GSK3B0.31636435
53MAP3K20.30555389
54MAP3K40.30493035
55RPS6KA10.30227272
56PRKCG0.29416547
57CAMK40.28657578
58BLK0.27354425
59MAP3K10.24766190
60SGK10.23622587
61JAK30.23279912
62PRKCZ0.22792477
63ROCK10.21987898
64CHEK10.21898254
65STK390.21535538
66SGK20.21277163
67NME10.20699300
68TNIK0.20476736
69MAPK80.20380418
70MTOR0.20138907
71MARK20.19034818
72WNK40.17656930
73MUSK0.17519042
74MAP3K80.17123289
75MAP3K100.16941950
76PRKCB0.16530093
77MAPK140.16370313
78NEK20.15747554
79MAPK100.14324538
80MET0.13889392
81MAP3K70.13779985
82UHMK10.13731225
83PRKACB0.11228850
84AKT10.11093813
85RPS6KL10.10004130
86RPS6KC10.10004130
87RPS6KA60.09554774
88PKN10.09052525
89OXSR10.08998814
90PLK10.07408746
91ICK0.06679860
92CSNK1A10.06529656
93MAP2K10.06074320
94PRKACA0.05769560
95MAPK110.05707711
96SGK30.05099120
97MAP2K70.05083581
98ARAF0.04865118
99TAF10.04317304
100FRK0.04003672

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.43507657
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.14041584
3Olfactory transduction_Homo sapiens_hsa047404.34012060
4RNA transport_Homo sapiens_hsa030132.74498474
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.69928320
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.03781772
7Taste transduction_Homo sapiens_hsa047421.92006173
8Butanoate metabolism_Homo sapiens_hsa006501.89787443
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81989791
10Fatty acid degradation_Homo sapiens_hsa000711.78640826
11Dorso-ventral axis formation_Homo sapiens_hsa043201.77605252
12Phenylalanine metabolism_Homo sapiens_hsa003601.76177992
13Type II diabetes mellitus_Homo sapiens_hsa049301.62317931
14Fatty acid metabolism_Homo sapiens_hsa012121.62123154
15Phototransduction_Homo sapiens_hsa047441.39431050
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37199185
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.30744119
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.23841199
19Inositol phosphate metabolism_Homo sapiens_hsa005621.19967986
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16804713
21Nicotine addiction_Homo sapiens_hsa050331.16290756
22Antigen processing and presentation_Homo sapiens_hsa046121.14575179
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13830304
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10513317
25Glutamatergic synapse_Homo sapiens_hsa047241.09387152
26Protein digestion and absorption_Homo sapiens_hsa049741.07390458
27ABC transporters_Homo sapiens_hsa020101.05365786
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03661204
29Type I diabetes mellitus_Homo sapiens_hsa049401.01943907
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00994324
31Salivary secretion_Homo sapiens_hsa049700.98796564
32VEGF signaling pathway_Homo sapiens_hsa043700.98651222
33Calcium signaling pathway_Homo sapiens_hsa040200.98612801
34Influenza A_Homo sapiens_hsa051640.98008111
35Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96982232
36Cardiac muscle contraction_Homo sapiens_hsa042600.96029458
37Arginine biosynthesis_Homo sapiens_hsa002200.95708400
38Morphine addiction_Homo sapiens_hsa050320.93393551
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93150886
40cAMP signaling pathway_Homo sapiens_hsa040240.91742061
41PPAR signaling pathway_Homo sapiens_hsa033200.89858458
42Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88169385
43Fat digestion and absorption_Homo sapiens_hsa049750.87406027
44Nitrogen metabolism_Homo sapiens_hsa009100.85037989
45Autoimmune thyroid disease_Homo sapiens_hsa053200.82603281
46Serotonergic synapse_Homo sapiens_hsa047260.82328639
47Synaptic vesicle cycle_Homo sapiens_hsa047210.81077257
48Allograft rejection_Homo sapiens_hsa053300.80919766
49Oocyte meiosis_Homo sapiens_hsa041140.79896164
50Pancreatic secretion_Homo sapiens_hsa049720.76659688
51Long-term potentiation_Homo sapiens_hsa047200.76533216
52Glycerolipid metabolism_Homo sapiens_hsa005610.75090921
53mRNA surveillance pathway_Homo sapiens_hsa030150.73732456
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73444807
55Fanconi anemia pathway_Homo sapiens_hsa034600.72799988
56Endocytosis_Homo sapiens_hsa041440.72553388
57Sulfur relay system_Homo sapiens_hsa041220.71333755
58Viral myocarditis_Homo sapiens_hsa054160.70451516
59Graft-versus-host disease_Homo sapiens_hsa053320.68623848
60Tyrosine metabolism_Homo sapiens_hsa003500.66568629
61Renin secretion_Homo sapiens_hsa049240.66404194
62Circadian entrainment_Homo sapiens_hsa047130.64819226
63Arginine and proline metabolism_Homo sapiens_hsa003300.63265211
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60447383
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60365008
66Retinol metabolism_Homo sapiens_hsa008300.59757564
67Bile secretion_Homo sapiens_hsa049760.55137603
68Hedgehog signaling pathway_Homo sapiens_hsa043400.54937905
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.54048182
70Amphetamine addiction_Homo sapiens_hsa050310.54017565
71Estrogen signaling pathway_Homo sapiens_hsa049150.52644551
72Gastric acid secretion_Homo sapiens_hsa049710.52455361
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50806548
74Insulin secretion_Homo sapiens_hsa049110.49812148
75Renin-angiotensin system_Homo sapiens_hsa046140.47660644
76ECM-receptor interaction_Homo sapiens_hsa045120.46443271
77MAPK signaling pathway_Homo sapiens_hsa040100.45172277
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45062592
79Biosynthesis of amino acids_Homo sapiens_hsa012300.43890835
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.41290162
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40735232
82GABAergic synapse_Homo sapiens_hsa047270.40410567
83Vitamin B6 metabolism_Homo sapiens_hsa007500.40165276
84Cholinergic synapse_Homo sapiens_hsa047250.37235648
85Huntingtons disease_Homo sapiens_hsa050160.32507023
86Oxytocin signaling pathway_Homo sapiens_hsa049210.32506335
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32401351
88Purine metabolism_Homo sapiens_hsa002300.30633418
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.27567498
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24601380
91Thyroid hormone synthesis_Homo sapiens_hsa049180.23502604
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22233426
93Acute myeloid leukemia_Homo sapiens_hsa052210.21626057
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20786710
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.20100110
96B cell receptor signaling pathway_Homo sapiens_hsa046620.18646071
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18464911
98HIF-1 signaling pathway_Homo sapiens_hsa040660.17202097
99Herpes simplex infection_Homo sapiens_hsa051680.17019521
100Tight junction_Homo sapiens_hsa045300.16887533

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »