C2ORF80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)9.91377292
2positive regulation of cell fate commitment (GO:0010455)9.10290248
3positive regulation of interleukin-17 production (GO:0032740)8.54486127
4negative regulation of interleukin-10 production (GO:0032693)8.33386801
5positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.11878721
6nucleoside transmembrane transport (GO:1901642)7.89164992
7positive regulation of T-helper 1 type immune response (GO:0002827)7.74948698
8regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)7.30809968
9positive regulation of defense response to virus by host (GO:0002230)7.16394965
10positive regulation of T-helper cell differentiation (GO:0045624)6.91104554
11cellular response to gamma radiation (GO:0071480)6.88885750
12regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.67199813
13fucose catabolic process (GO:0019317)6.38803811
14L-fucose metabolic process (GO:0042354)6.38803811
15L-fucose catabolic process (GO:0042355)6.38803811
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.27914211
17ribosomal small subunit biogenesis (GO:0042274)6.13093391
18C4-dicarboxylate transport (GO:0015740)5.89590495
19microtubule severing (GO:0051013)5.88010876
20positive regulation of alpha-beta T cell proliferation (GO:0046641)5.82545330
21DNA double-strand break processing (GO:0000729)5.55452266
22positive regulation of T cell mediated cytotoxicity (GO:0001916)5.52652483
23pyrimidine nucleotide catabolic process (GO:0006244)5.50163203
24regulation of T-helper 1 type immune response (GO:0002825)5.48846964
25nucleoside transport (GO:0015858)5.42427746
26neurofilament cytoskeleton organization (GO:0060052)5.28172310
27positive regulation of neutrophil migration (GO:1902624)5.12161382
28positive regulation of neutrophil chemotaxis (GO:0090023)5.12161382
29positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)5.11924783
30positive regulation of natural killer cell activation (GO:0032816)5.10346750
31positive regulation of activated T cell proliferation (GO:0042104)5.04203770
32synapsis (GO:0007129)5.01273324
33behavioral response to nicotine (GO:0035095)5.00245518
34regulation of T-helper cell differentiation (GO:0045622)4.96471243
35positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)4.76735400
36L-serine transport (GO:0015825)4.76467423
37positive regulation of granulocyte chemotaxis (GO:0071624)4.60847134
38regulation of T cell mediated cytotoxicity (GO:0001914)4.51399872
39regulation of interleukin-17 production (GO:0032660)4.50226022
40basic amino acid transport (GO:0015802)4.47885367
41positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.45205433
42cellular anion homeostasis (GO:0030002)4.43262526
43viral transcription (GO:0019083)4.37859170
44translational termination (GO:0006415)4.34605967
45regulation of alpha-beta T cell proliferation (GO:0046640)4.23711152
46positive regulation of osteoclast differentiation (GO:0045672)4.21082799
47opioid receptor signaling pathway (GO:0038003)4.15204783
48serine transport (GO:0032329)4.12526512
49positive regulation of NF-kappaB import into nucleus (GO:0042346)4.12273758
50gamma-aminobutyric acid transport (GO:0015812)4.03385562
51regulation of neutrophil chemotaxis (GO:0090022)3.99704420
52regulation of neutrophil migration (GO:1902622)3.99704420
53transcription elongation from RNA polymerase I promoter (GO:0006362)3.96891488
54neuronal action potential propagation (GO:0019227)3.85594729
55labyrinthine layer development (GO:0060711)3.85424902
56regulation of cell fate commitment (GO:0010453)3.83294122
57regulation of defense response to virus by host (GO:0050691)3.81393394
58regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.79628809
59regulation of natural killer cell activation (GO:0032814)3.72600213
60regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.71792409
61regulation of protein heterodimerization activity (GO:0043497)3.65637060
62positive regulation of interleukin-10 production (GO:0032733)3.64391758
63alanine transport (GO:0032328)3.63883733
64positive regulation of megakaryocyte differentiation (GO:0045654)3.55521294
65positive regulation of tissue remodeling (GO:0034105)3.52308582
66regulation of activated T cell proliferation (GO:0046006)3.49391832
67protein palmitoylation (GO:0018345)3.48769364
68L-glutamate transport (GO:0015813)3.45987063
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.44670820
70type B pancreatic cell proliferation (GO:0044342)3.40338576
71acidic amino acid transport (GO:0015800)3.37077470
72female gamete generation (GO:0007292)3.34151798
73positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.32712659
74modified amino acid transport (GO:0072337)3.32107363
75translational elongation (GO:0006414)3.30952101
76cellular protein complex disassembly (GO:0043624)3.29009178
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27367208
78regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.26570485
79valine metabolic process (GO:0006573)3.25243285
80cotranslational protein targeting to membrane (GO:0006613)3.21366816
81defense response to Gram-negative bacterium (GO:0050829)3.20297542
82relaxation of smooth muscle (GO:0044557)3.18559218
83protein targeting to ER (GO:0045047)3.15350294
84positive regulation of T cell mediated immunity (GO:0002711)3.14473575
85fucose metabolic process (GO:0006004)3.12167392
86fucosylation (GO:0036065)3.12051815
87viral life cycle (GO:0019058)3.09648398
88male meiosis I (GO:0007141)3.09232464
89positive regulation of interleukin-12 production (GO:0032735)3.08987451
90hydrogen peroxide biosynthetic process (GO:0050665)3.08558298
91estrogen biosynthetic process (GO:0006703)3.08322218
92positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.03170075
93regulation of granulocyte chemotaxis (GO:0071622)3.00942211
94establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99469724
95negative regulation of protein oligomerization (GO:0032460)2.98684887
96protein localization to endoplasmic reticulum (GO:0070972)2.90350620
97positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.88761284
98regulation of memory T cell differentiation (GO:0043380)14.2986691
99regulation of activation of Janus kinase activity (GO:0010533)12.3875692
100positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)10.9192855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.41498762
2GATA1_22025678_ChIP-Seq_K562_Human4.26680650
3EZH2_22144423_ChIP-Seq_EOC_Human3.59991735
4GATA1_26923725_Chip-Seq_HPCs_Mouse3.49301756
5IGF1R_20145208_ChIP-Seq_DFB_Human3.43351261
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.27925750
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.80205159
8GBX2_23144817_ChIP-Seq_PC3_Human2.78554451
9TAF15_26573619_Chip-Seq_HEK293_Human2.67886941
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64845613
11VDR_22108803_ChIP-Seq_LS180_Human2.61525240
12EWS_26573619_Chip-Seq_HEK293_Human2.41578390
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39527308
14REST_21632747_ChIP-Seq_MESCs_Mouse2.30644625
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24956999
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.17584588
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12960653
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01898235
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00966234
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97615613
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96160021
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.88251195
23RNF2_27304074_Chip-Seq_NSC_Mouse1.86650208
24AR_21572438_ChIP-Seq_LNCaP_Human1.85315439
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.82817961
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82588142
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77956258
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77956258
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76585151
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.72525102
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72482035
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71726744
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68078197
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68015456
35DROSHA_22980978_ChIP-Seq_HELA_Human1.66468373
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62225020
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58855640
38* TAF2_19829295_ChIP-Seq_ESCs_Human1.57820116
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57260040
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51652340
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51087139
42NANOG_19829295_ChIP-Seq_ESCs_Human1.45002622
43SOX2_19829295_ChIP-Seq_ESCs_Human1.45002622
44BCAT_22108803_ChIP-Seq_LS180_Human1.40336362
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38250025
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.35864556
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.35000395
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.34358150
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32207741
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31987793
51SMAD3_21741376_ChIP-Seq_ESCs_Human1.31651839
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.29878996
53GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.28881663
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26860428
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26000420
56ER_23166858_ChIP-Seq_MCF-7_Human1.25665380
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24580495
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23761872
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23450741
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23117524
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21074549
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19877685
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19531591
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.19293800
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17724863
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17589756
67P300_19829295_ChIP-Seq_ESCs_Human1.17241425
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16848531
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15700713
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15667240
71WDR5_24793694_ChIP-Seq_LNCAP_Human1.14817188
72CBP_20019798_ChIP-Seq_JUKART_Human1.14749676
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14749676
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14346498
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13732839
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13567421
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12864249
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09956916
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06511810
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.05627932
81HTT_18923047_ChIP-ChIP_STHdh_Human1.05303432
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04944494
83AR_25329375_ChIP-Seq_VCAP_Human1.04693724
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03864140
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03660308
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03531669
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02626045
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02488332
89SMAD4_21799915_ChIP-Seq_A2780_Human0.98779132
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97995551
91SOX9_26525672_Chip-Seq_HEART_Mouse0.96926958
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95986469
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95322079
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.95262039
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94724409
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.93738493
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93591318
98OCT4_20526341_ChIP-Seq_ESCs_Human0.92454679
99ERG_20517297_ChIP-Seq_VCAP_Human0.91552767
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91492228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.65915438
2MP0003303_peritoneal_inflammation4.99103568
3MP0005360_urolithiasis4.85693368
4MP0001984_abnormal_olfaction4.73534437
5MP0010386_abnormal_urinary_bladder3.68048957
6MP0003252_abnormal_bile_duct3.21333967
7MP0005085_abnormal_gallbladder_physiolo2.89723824
8MP0009046_muscle_twitch2.74320439
9MP0004885_abnormal_endolymph2.65156217
10MP0002876_abnormal_thyroid_physiology2.62458210
11MP0003300_gastrointestinal_ulcer2.50139757
12MP0009785_altered_susceptibility_to2.49640026
13MP0004270_analgesia2.40954520
14MP0009765_abnormal_xenobiotic_induced2.36958429
15MP0002160_abnormal_reproductive_system2.29230910
16MP0002638_abnormal_pupillary_reflex2.17011621
17MP0009745_abnormal_behavioral_response2.15568813
18MP0002102_abnormal_ear_morphology2.12464924
19MP0003880_abnormal_central_pattern2.07814430
20MP0006292_abnormal_olfactory_placode2.06774052
21MP0005389_reproductive_system_phenotype1.88713025
22MP0002064_seizures1.76308670
23MP0004142_abnormal_muscle_tone1.75830317
24MP0001968_abnormal_touch/_nociception1.71708334
25MP0005423_abnormal_somatic_nervous1.66534124
26MP0002734_abnormal_mechanical_nocicepti1.58265372
27MP0008872_abnormal_physiological_respon1.58005791
28MP0001661_extended_life_span1.55168060
29MP0002736_abnormal_nociception_after1.53661806
30MP0001970_abnormal_pain_threshold1.50448675
31MP0001501_abnormal_sleep_pattern1.49630225
32MP0002272_abnormal_nervous_system1.49360205
33MP0005671_abnormal_response_to1.40271810
34MP0002735_abnormal_chemical_nociception1.38097118
35MP0004742_abnormal_vestibular_system1.38045669
36MP0002822_catalepsy1.36831118
37MP0002733_abnormal_thermal_nociception1.33458817
38MP0000538_abnormal_urinary_bladder1.28345091
39MP0010155_abnormal_intestine_physiology1.25595826
40MP0002837_dystrophic_cardiac_calcinosis1.23325389
41MP0003635_abnormal_synaptic_transmissio1.21981213
42MP0001542_abnormal_bone_strength1.16959894
43MP0009379_abnormal_foot_pigmentation1.16478190
44MP0010352_gastrointestinal_tract_polyps1.15971171
45MP0005551_abnormal_eye_electrophysiolog1.15176480
46MP0002572_abnormal_emotion/affect_behav1.14134875
47MP0003136_yellow_coat_color1.11824164
48MP0001790_abnormal_immune_system1.10307994
49MP0005387_immune_system_phenotype1.10307994
50MP0006072_abnormal_retinal_apoptosis1.08885279
51MP0006276_abnormal_autonomic_nervous1.04561669
52MP0000343_altered_response_to1.04250601
53MP0008874_decreased_physiological_sensi1.02071823
54MP0000631_abnormal_neuroendocrine_gland1.00578062
55MP0005000_abnormal_immune_tolerance0.99361809
56MP0000026_abnormal_inner_ear0.97444575
57MP0005647_abnormal_sex_gland0.97303400
58MP0002067_abnormal_sensory_capabilities0.96982108
59MP0000955_abnormal_spinal_cord0.95545631
60MP0001986_abnormal_taste_sensitivity0.94454566
61MP0001919_abnormal_reproductive_system0.91807852
62MP0002063_abnormal_learning/memory/cond0.85924370
63MP0001963_abnormal_hearing_physiology0.85689261
64MP0004859_abnormal_synaptic_plasticity0.84540025
65MP0002184_abnormal_innervation0.84350091
66MP0001800_abnormal_humoral_immune0.83876055
67MP0003195_calcinosis0.83376134
68MP0001486_abnormal_startle_reflex0.81125706
69MP0005386_behavior/neurological_phenoty0.80465149
70MP0004924_abnormal_behavior0.80465149
71MP0000490_abnormal_crypts_of0.80209879
72MP0004145_abnormal_muscle_electrophysio0.79457895
73MP0010329_abnormal_lipoprotein_level0.78679853
74MP0001502_abnormal_circadian_rhythm0.76997292
75MP0009763_increased_sensitivity_to0.75441909
76MP0003866_abnormal_defecation0.74713740
77MP0004130_abnormal_muscle_cell0.73567332
78MP0005636_abnormal_mineral_homeostasis0.73516289
79MP0010234_abnormal_vibrissa_follicle0.72216015
80MP0003690_abnormal_glial_cell0.71055776
81MP0003638_abnormal_response/metabolism_0.69572216
82MP0002132_abnormal_respiratory_system0.69423977
83MP0002277_abnormal_respiratory_mucosa0.69131569
84MP0003632_abnormal_nervous_system0.68386723
85MP0005332_abnormal_amino_acid0.67435550
86MP0002090_abnormal_vision0.66027373
87MP0005645_abnormal_hypothalamus_physiol0.63594526
88MP0001119_abnormal_female_reproductive0.62457521
89MP0001663_abnormal_digestive_system0.61409976
90MP0001727_abnormal_embryo_implantation0.61112024
91MP0003011_delayed_dark_adaptation0.60533053
92MP0002752_abnormal_somatic_nervous0.59891904
93MP0002882_abnormal_neuron_morphology0.57665040
94MP0002557_abnormal_social/conspecific_i0.57294495
95MP0002169_no_abnormal_phenotype0.56307990
96MP0002873_normal_phenotype0.56192015
97MP0003646_muscle_fatigue0.55783908
98MP0003878_abnormal_ear_physiology0.55073330
99MP0005377_hearing/vestibular/ear_phenot0.55073330
100MP0005253_abnormal_eye_physiology0.54006171

Predicted human phenotypes

RankGene SetZ-score
1Decreased subcutaneous fat (HP:0001002)9.10765573
2Fragile nails (HP:0001808)8.93632633
3Erythroderma (HP:0001019)7.49793971
4Congenital ichthyosiform erythroderma (HP:0007431)7.01576421
5Conjugated hyperbilirubinemia (HP:0002908)6.83174850
6Abnormality of subcutaneous fat tissue (HP:0001001)6.62740168
7Brittle hair (HP:0002299)6.36166836
8IgG deficiency (HP:0004315)4.97498566
9Congenital sensorineural hearing impairment (HP:0008527)4.42056841
10Degeneration of the lateral corticospinal tracts (HP:0002314)4.33399330
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.33399330
12Parakeratosis (HP:0001036)4.16496499
13Thyroid-stimulating hormone excess (HP:0002925)3.60943629
14Degeneration of anterior horn cells (HP:0002398)3.51558175
15Abnormality of the anterior horn cell (HP:0006802)3.51558175
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.50367971
17Abnormality of alanine metabolism (HP:0010916)3.50367971
18Hyperalaninemia (HP:0003348)3.50367971
19Abnormality of the corticospinal tract (HP:0002492)3.40410810
20Depressed nasal tip (HP:0000437)3.36998463
21Abnormality of the vocal cords (HP:0008777)3.27610001
22Adrenal hypoplasia (HP:0000835)3.21483387
23Neoplasm of head and neck (HP:0012288)3.17101292
24Esophageal neoplasm (HP:0100751)3.17101292
25Bulbous nose (HP:0000414)2.86648450
26High pitched voice (HP:0001620)2.85347491
27Congenital stationary night blindness (HP:0007642)2.81341921
28Retrobulbar optic neuritis (HP:0100654)2.78271047
29Optic neuritis (HP:0100653)2.78271047
30Barrel-shaped chest (HP:0001552)2.73105467
31Asthma (HP:0002099)2.65458349
32Mediastinal lymphadenopathy (HP:0100721)2.59642246
33Macrocytic anemia (HP:0001972)2.58080652
34Clubbing of toes (HP:0100760)2.55765999
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49599287
36Optic nerve hypoplasia (HP:0000609)2.44140830
37Intestinal atresia (HP:0011100)2.33084715
38Genetic anticipation (HP:0003743)2.28485623
39Opisthotonus (HP:0002179)2.28155120
40Progressive cerebellar ataxia (HP:0002073)2.27492916
41Focal seizures (HP:0007359)2.27400751
42Metaphyseal dysplasia (HP:0100255)2.27330396
43Cutaneous photosensitivity (HP:0000992)2.25542255
44Mesomelia (HP:0003027)2.24269136
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.23865850
46Hypoplasia of the fovea (HP:0007750)2.23865850
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20836552
48Abnormality of the ileum (HP:0001549)2.18686840
49Orchitis (HP:0100796)2.18557999
50Pseudobulbar signs (HP:0002200)2.15149695
51Ectopic kidney (HP:0000086)2.14862916
52Absent epiphyses (HP:0010577)2.11458227
53Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.11458227
54Pallor (HP:0000980)2.08765536
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08606723
56Recurrent sinusitis (HP:0011108)2.07609508
57Clumsiness (HP:0002312)2.02565095
58Congenital, generalized hypertrichosis (HP:0004540)2.01529508
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)11.5849415
60Gaze-evoked nystagmus (HP:0000640)1.98941730
61Absent thumb (HP:0009777)1.96921941
62Morphological abnormality of the pyramidal tract (HP:0002062)1.93775510
63Stomatitis (HP:0010280)1.89296873
64Hypoplasia of the radius (HP:0002984)1.88402223
65Dysphonia (HP:0001618)1.88003427
66Dialeptic seizures (HP:0011146)1.87625798
67Abnormality of the fovea (HP:0000493)1.87588492
68Abnormality of the lower motor neuron (HP:0002366)1.87277645
69Focal motor seizures (HP:0011153)1.86094162
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.85877458
71Increased neuronal autofluorescent lipopigment (HP:0002074)1.84636885
72Keratoconjunctivitis sicca (HP:0001097)1.83213610
73Oral leukoplakia (HP:0002745)1.81174082
74Abnormality of dental color (HP:0011073)1.80918935
75Thickened helices (HP:0000391)1.79474752
76Abnormal eating behavior (HP:0100738)1.77999326
77Keratoconjunctivitis (HP:0001096)1.77560806
78Sleep apnea (HP:0010535)1.75797151
79Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75744970
80Febrile seizures (HP:0002373)1.73126770
81Abnormal rod and cone electroretinograms (HP:0008323)1.72753760
82Nephrocalcinosis (HP:0000121)1.70660748
83Myositis (HP:0100614)1.68306380
84Generalized tonic-clonic seizures (HP:0002069)1.67538299
85Increased serum pyruvate (HP:0003542)1.65782368
86Squamous cell carcinoma (HP:0002860)1.64907983
87Spinal muscular atrophy (HP:0007269)1.64273935
88Abnormality of the gastric mucosa (HP:0004295)1.63639160
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.62656446
90Short palpebral fissure (HP:0012745)1.60912716
91Palmoplantar hyperkeratosis (HP:0000972)1.60895635
92Disproportionate short-trunk short stature (HP:0003521)1.57918924
93Ulnar claw (HP:0001178)1.57657959
94Spastic paraplegia (HP:0001258)1.57574641
95Pheochromocytoma (HP:0002666)1.56664744
96Difficulty climbing stairs (HP:0003551)1.56646785
97Meckel diverticulum (HP:0002245)1.55638949
98Megalencephaly (HP:0001355)1.54622837
99Depressed nasal ridge (HP:0000457)1.53431485
100Paraplegia (HP:0010550)1.52657446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.94979464
2ERN15.90104557
3ADRBK23.90775905
4MAP3K93.78412467
5ARAF3.59001437
6EEF2K3.13101747
7MAP3K133.00895394
8JAK32.44273443
9ADRBK12.37379335
10ITK2.26395563
11KSR22.20487269
12STK112.07550322
13MAPKAPK31.97262859
14STK31.95087209
15PTK61.92919530
16MOS1.91778154
17CDK191.83484458
18MAPK131.78526172
19PRKCG1.74112553
20MARK11.39310315
21MAPKAPK51.38799428
22KSR11.35137016
23CASK1.29224451
24PRKCI1.27707897
25WNK31.26997676
26PRKCZ1.16428762
27PRKCE1.15143592
28MAP4K21.08421360
29INSRR1.07069959
30JAK21.04541891
31CAMK2B1.04078483
32NTRK21.03604242
33FRK1.02255964
34MATK0.96974323
35EPHA40.94072316
36MAP3K40.89756937
37PINK10.89071438
38TRPM70.86232467
39WNK10.85731204
40BRAF0.83189939
41GRK10.82227193
42PRKCD0.79450488
43CAMK2G0.78077152
44CDK70.77168278
45PKN10.74977249
46CAMK2D0.74576448
47MST1R0.69886318
48MUSK0.65138029
49RPS6KB20.64881275
50CLK10.64078893
51MAPK120.63722976
52TEC0.63437912
53MAPK150.63118619
54GRK70.61842364
55TNIK0.57077056
56OBSCN0.56820425
57TXK0.53701186
58RAF10.53008174
59TIE10.51676610
60CAMK2A0.48388938
61MAP2K70.48369705
62PRKCB0.47321885
63PRKCA0.42189519
64PDK10.39647248
65DYRK20.39295981
66NTRK30.38914839
67PHKG10.37783205
68PHKG20.37783205
69PRKACB0.36324855
70MAP3K20.36105386
71CHUK0.35014998
72CSNK1D0.34909202
73IGF1R0.34470445
74GRK50.31426314
75PRKCH0.30248884
76MARK30.30053194
77MAP2K10.29958422
78DYRK1A0.28993769
79OXSR10.28832524
80WNK40.28467684
81PRKACA0.27982431
82DAPK20.27369259
83UHMK10.26327629
84FGFR30.24540512
85PLK40.24442050
86SYK0.22699309
87TLK10.20252936
88FES0.18202768
89PAK30.17913699
90PRKACG0.17772726
91ZAK0.17621788
92MAP2K20.16647711
93ERBB40.16636939
94FYN0.16333575
95PNCK0.16029796
96PRKG10.15147155
97WEE10.15073084
98RPS6KA50.14007485
99PDPK10.13112175
100PLK20.12338122

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.02303644
2Ribosome_Homo sapiens_hsa030104.29121744
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.01746605
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.51248323
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.23197729
6Basal transcription factors_Homo sapiens_hsa030222.84858743
7Rheumatoid arthritis_Homo sapiens_hsa053232.34905278
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.29846756
9Pertussis_Homo sapiens_hsa051332.27000591
10Asthma_Homo sapiens_hsa053102.19147480
11Nucleotide excision repair_Homo sapiens_hsa034202.17288190
12Nicotine addiction_Homo sapiens_hsa050332.03304407
13Histidine metabolism_Homo sapiens_hsa003401.88005702
14Allograft rejection_Homo sapiens_hsa053301.72082122
15Autoimmune thyroid disease_Homo sapiens_hsa053201.70303275
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65238144
17Phototransduction_Homo sapiens_hsa047441.61827853
18Morphine addiction_Homo sapiens_hsa050321.54717623
19Staphylococcus aureus infection_Homo sapiens_hsa051501.47474536
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45121930
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44892976
22ABC transporters_Homo sapiens_hsa020101.38606325
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.36362607
24Type I diabetes mellitus_Homo sapiens_hsa049401.29747673
25Tryptophan metabolism_Homo sapiens_hsa003801.27235843
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26362603
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25615751
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.25522588
29GABAergic synapse_Homo sapiens_hsa047271.25198261
30Prion diseases_Homo sapiens_hsa050201.18864146
31Taste transduction_Homo sapiens_hsa047421.12973270
32Glutamatergic synapse_Homo sapiens_hsa047241.09668110
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09101353
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08464413
35Cholinergic synapse_Homo sapiens_hsa047251.04882557
36beta-Alanine metabolism_Homo sapiens_hsa004101.04387633
37Retinol metabolism_Homo sapiens_hsa008301.02096118
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01465073
39Graft-versus-host disease_Homo sapiens_hsa053321.00060594
40Arginine and proline metabolism_Homo sapiens_hsa003300.98505833
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.96576063
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96094591
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95739498
44Chemical carcinogenesis_Homo sapiens_hsa052040.95462121
45Nitrogen metabolism_Homo sapiens_hsa009100.95442021
46Selenocompound metabolism_Homo sapiens_hsa004500.95191828
47Hematopoietic cell lineage_Homo sapiens_hsa046400.89603837
48Circadian entrainment_Homo sapiens_hsa047130.88375784
49Bile secretion_Homo sapiens_hsa049760.86366492
50Collecting duct acid secretion_Homo sapiens_hsa049660.85658395
51Serotonergic synapse_Homo sapiens_hsa047260.83031667
52Cocaine addiction_Homo sapiens_hsa050300.81408139
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80374760
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78269914
55Olfactory transduction_Homo sapiens_hsa047400.77495645
56Systemic lupus erythematosus_Homo sapiens_hsa053220.77311965
57Pyrimidine metabolism_Homo sapiens_hsa002400.75660799
58Oxidative phosphorylation_Homo sapiens_hsa001900.73599283
59Leishmaniasis_Homo sapiens_hsa051400.72066394
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71331082
61Fat digestion and absorption_Homo sapiens_hsa049750.69332888
62Tuberculosis_Homo sapiens_hsa051520.69045583
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65447927
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64197403
65Malaria_Homo sapiens_hsa051440.62882023
66Dilated cardiomyopathy_Homo sapiens_hsa054140.62449152
67African trypanosomiasis_Homo sapiens_hsa051430.61773953
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61478542
69Linoleic acid metabolism_Homo sapiens_hsa005910.59272325
70Long-term depression_Homo sapiens_hsa047300.58748907
71Glycerolipid metabolism_Homo sapiens_hsa005610.57177423
72Synaptic vesicle cycle_Homo sapiens_hsa047210.57042224
73Cardiac muscle contraction_Homo sapiens_hsa042600.56490644
74Parkinsons disease_Homo sapiens_hsa050120.56288194
75Ovarian steroidogenesis_Homo sapiens_hsa049130.54796819
76mTOR signaling pathway_Homo sapiens_hsa041500.54705403
77Protein digestion and absorption_Homo sapiens_hsa049740.54094862
78Dopaminergic synapse_Homo sapiens_hsa047280.53439888
79Caffeine metabolism_Homo sapiens_hsa002320.45932605
80Renin secretion_Homo sapiens_hsa049240.42935218
81cAMP signaling pathway_Homo sapiens_hsa040240.42626539
82Arachidonic acid metabolism_Homo sapiens_hsa005900.39752477
83Chemokine signaling pathway_Homo sapiens_hsa040620.38847990
84Gap junction_Homo sapiens_hsa045400.37852865
85Primary immunodeficiency_Homo sapiens_hsa053400.37090302
86Gastric acid secretion_Homo sapiens_hsa049710.36360516
87Amphetamine addiction_Homo sapiens_hsa050310.32769977
88Oxytocin signaling pathway_Homo sapiens_hsa049210.32361646
89Alcoholism_Homo sapiens_hsa050340.32117916
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31724927
91Antigen processing and presentation_Homo sapiens_hsa046120.29760078
92Phagosome_Homo sapiens_hsa041450.29533110
93PPAR signaling pathway_Homo sapiens_hsa033200.28500343
94Hedgehog signaling pathway_Homo sapiens_hsa043400.27637229
95Calcium signaling pathway_Homo sapiens_hsa040200.26883764
96Axon guidance_Homo sapiens_hsa043600.26501547
97Peroxisome_Homo sapiens_hsa041460.24507675
98ECM-receptor interaction_Homo sapiens_hsa045120.23497479
99Regulation of autophagy_Homo sapiens_hsa041400.19788872
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18964550

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »