ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	7.41012344
2	cilium or flagellum-dependent cell motility (GO:0001539)	7.22399878
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.19813114
4	epithelial cilium movement (GO:0003351)	6.70018401
5	cilium movement (GO:0003341)	6.65332464
6	axoneme assembly (GO:0035082)	5.53406392
7	behavioral response to nicotine (GO:0035095)	5.25857586
8	motile cilium assembly (GO:0044458)	4.99847551
9	regulation of cilium movement (GO:0003352)	4.67281393
10	fucose catabolic process (GO:0019317)	4.31571062
11	L-fucose metabolic process (GO:0042354)	4.31571062
12	L-fucose catabolic process (GO:0042355)	4.31571062
13	cilium organization (GO:0044782)	4.05737243
14	cilium assembly (GO:0042384)	3.94008276
15	protein localization to cilium (GO:0061512)	3.88252238
16	response to pheromone (GO:0019236)	3.79060214
17	intraciliary transport (GO:0042073)	3.76455875
18	cilium morphogenesis (GO:0060271)	3.70152139
19	indolalkylamine metabolic process (GO:0006586)	3.66921219
20	DNA deamination (GO:0045006)	3.63586624
21	indole-containing compound catabolic process (GO:0042436)	3.61228990
22	indolalkylamine catabolic process (GO:0046218)	3.61228990
23	tryptophan catabolic process (GO:0006569)	3.61228990
24	kynurenine metabolic process (GO:0070189)	3.47332535
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.44678893
26	nonmotile primary cilium assembly (GO:0035058)	3.36154022
27	protein polyglutamylation (GO:0018095)	3.35490381
28	regulation of microtubule-based movement (GO:0060632)	3.31720463
29	cellular ketone body metabolic process (GO:0046950)	3.28658451
30	left/right axis specification (GO:0070986)	3.24291553
31	tryptophan metabolic process (GO:0006568)	3.21171891
32	detection of light stimulus involved in visual perception (GO:0050908)	3.18073324
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.18073324
34	photoreceptor cell maintenance (GO:0045494)	3.14167435
35	retinal cone cell development (GO:0046549)	3.08003859
36	left/right pattern formation (GO:0060972)	3.07831780
37	cornea development in camera-type eye (GO:0061303)	3.06538225
38	cellular component assembly involved in morphogenesis (GO:0010927)	3.05245202
39	water-soluble vitamin biosynthetic process (GO:0042364)	2.99889292
40	indole-containing compound metabolic process (GO:0042430)	2.98003793
41	negative regulation of telomere maintenance (GO:0032205)	2.97849373
42	ketone body metabolic process (GO:1902224)	2.97792636
43	microtubule bundle formation (GO:0001578)	2.96347082
44	neural tube formation (GO:0001841)	2.96231157
45	rRNA catabolic process (GO:0016075)	2.93825712
46	negative regulation of T cell differentiation in thymus (GO:0033085)	2.92243667
47	platelet dense granule organization (GO:0060155)	2.92183716
48	centriole replication (GO:0007099)	2.88511923
49	piRNA metabolic process (GO:0034587)	2.88361502
50	neuronal action potential (GO:0019228)	2.83026858
51	sperm motility (GO:0030317)	2.78441266
52	sulfation (GO:0051923)	2.77766811
53	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.76534496
54	response to xenobiotic stimulus (GO:0009410)	2.75956023
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75847986
56	exogenous drug catabolic process (GO:0042738)	2.75225995
57	primary amino compound metabolic process (GO:1901160)	2.74864828
58	kidney morphogenesis (GO:0060993)	2.71385236
59	serotonin metabolic process (GO:0042428)	2.70344650
60	gamma-aminobutyric acid transport (GO:0015812)	2.69367653
61	multicellular organism reproduction (GO:0032504)	2.66416997
62	benzene-containing compound metabolic process (GO:0042537)	2.62764611
63	photoreceptor cell development (GO:0042461)	2.61685873
64	drug catabolic process (GO:0042737)	2.60241978
65	protein complex biogenesis (GO:0070271)	2.58720421
66	smoothened signaling pathway (GO:0007224)	2.58645438
67	respiratory chain complex IV assembly (GO:0008535)	2.58522580
68	centriole assembly (GO:0098534)	2.56668774
69	behavioral response to ethanol (GO:0048149)	2.56637396
70	amine catabolic process (GO:0009310)	2.55767147
71	cellular biogenic amine catabolic process (GO:0042402)	2.55767147
72	spinal cord motor neuron differentiation (GO:0021522)	2.54922514
73	DNA methylation involved in gamete generation (GO:0043046)	2.53650115
74	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.51986918
75	NADH dehydrogenase complex assembly (GO:0010257)	2.51986918
76	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.51986918
77	ventricular system development (GO:0021591)	2.50137335
78	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50017406
79	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.49986160
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.49986160
81	reflex (GO:0060004)	2.49567743
82	neurotransmitter metabolic process (GO:0042133)	2.48496909
83	auditory receptor cell stereocilium organization (GO:0060088)	2.48342186
84	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47548390
85	cell projection assembly (GO:0030031)	2.45191372
86	rhodopsin mediated signaling pathway (GO:0016056)	2.45102083
87	determination of left/right symmetry (GO:0007368)	2.44726187
88	thyroid hormone metabolic process (GO:0042403)	2.43619608
89	synaptic transmission, cholinergic (GO:0007271)	2.43268435
90	mannosylation (GO:0097502)	2.41968879
91	cytochrome complex assembly (GO:0017004)	2.41864366
92	positive regulation of fatty acid transport (GO:2000193)	2.40774722
93	regulation of collateral sprouting (GO:0048670)	2.39625917
94	inner ear receptor stereocilium organization (GO:0060122)	2.39603429
95	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.38965370
96	transmission of nerve impulse (GO:0019226)	2.38895457
97	regulation of hippo signaling (GO:0035330)	2.38022229
98	regulation of action potential (GO:0098900)	2.37902148
99	ubiquinone biosynthetic process (GO:0006744)	2.36400535
100	reciprocal DNA recombination (GO:0035825)	2.33663040

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.74548999
2	VDR_22108803_ChIP-Seq_LS180_Human	3.36681169
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.77678189
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.75142180
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.60832773
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.49094850
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41996204
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33578062
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18929305
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.14309589
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10682421
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09167299
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00164588
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.00114182
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.95278516
16	EWS_26573619_Chip-Seq_HEK293_Human	1.95226243
17	FUS_26573619_Chip-Seq_HEK293_Human	1.94015251
18	P300_19829295_ChIP-Seq_ESCs_Human	1.86592544
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80114882
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.73140898
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65458838
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64014880
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.63068163
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.62042400
25	STAT3_23295773_ChIP-Seq_U87_Human	1.57259366
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55524490
27	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55350166
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49682103
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.49395239
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49395239
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49257538
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48272756
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.46589295
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45704361
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45704361
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.45504951
37	TCF4_23295773_ChIP-Seq_U87_Human	1.45454810
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.44838343
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43179405
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39943746
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38785526
42	AR_25329375_ChIP-Seq_VCAP_Human	1.38594252
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36949852
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36730511
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.36704525
46	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36513602
47	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36513602
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35082870
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34542239
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34542239
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33997255
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33941300
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.33465289
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32268620
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31598344
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.30108885
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27750532
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26597853
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25242784
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24895981
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.24772146
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24312461
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24043639
64	AR_20517297_ChIP-Seq_VCAP_Human	1.23130162
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20043018
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19856936
67	NCOR_22424771_ChIP-Seq_293T_Human	1.19032352
68	MYC_18940864_ChIP-ChIP_HL60_Human	1.18656079
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18586834
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18298267
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.18065460
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17049438
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16793817
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16291783
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14116758
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13058018
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11072734
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09253496
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08543617
80	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.07378747
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07005683
82	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.05888683
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04612205
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.03064324
85	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99163806
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97812073
87	CDX2_22108803_ChIP-Seq_LS180_Human	0.97516400
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97373469
89	ERA_21632823_ChIP-Seq_H3396_Human	0.96861512
90	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96834248
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96184518
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95446121
93	ETV1_20927104_ChIP-Seq_GIST48_Human	0.95316924
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95027799
95	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94806532
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94699151
97	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.94144540
98	AHR_22903824_ChIP-Seq_MCF-7_Human	0.93771773
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.92999390
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92966726

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	2.98768221
2	MP0002653_abnormal_ependyma_morphology	2.82769218
3	MP0008877_abnormal_DNA_methylation	2.59187337
4	MP0004043_abnormal_pH_regulation	2.44813114
5	MP0005551_abnormal_eye_electrophysiolog	2.43265270
6	MP0003195_calcinosis	2.36620369
7	MP0002102_abnormal_ear_morphology	2.34260214
8	MP0001968_abnormal_touch/_nociception	2.30277942
9	MP0009046_muscle_twitch	2.15073783
10	MP0001984_abnormal_olfaction	2.13042563
11	MP0004133_heterotaxia	2.12108946
12	MP0003136_yellow_coat_color	2.07456153
13	MP0002638_abnormal_pupillary_reflex	2.04318026
14	MP0005646_abnormal_pituitary_gland	1.99197345
15	MP0002876_abnormal_thyroid_physiology	1.97679563
16	MP0003787_abnormal_imprinting	1.92240144
17	MP0009745_abnormal_behavioral_response	1.89911964
18	MP0004142_abnormal_muscle_tone	1.86839229
19	MP0001986_abnormal_taste_sensitivity	1.86146100
20	MP0008872_abnormal_physiological_respon	1.85714361
21	MP0000569_abnormal_digit_pigmentation	1.82926235
22	MP0005253_abnormal_eye_physiology	1.79124076
23	MP0002736_abnormal_nociception_after	1.77991976
24	MP0006072_abnormal_retinal_apoptosis	1.77708423
25	MP0003878_abnormal_ear_physiology	1.74645057
26	MP0005377_hearing/vestibular/ear_phenot	1.74645057
27	MP0004885_abnormal_endolymph	1.73074998
28	MP0006292_abnormal_olfactory_placode	1.72604444
29	MP0001485_abnormal_pinna_reflex	1.67943477
30	MP0003646_muscle_fatigue	1.67898006
31	MP0003880_abnormal_central_pattern	1.67146218
32	MP0002837_dystrophic_cardiac_calcinosis	1.66522232
33	MP0006276_abnormal_autonomic_nervous	1.64052607
34	MP0002272_abnormal_nervous_system	1.63842325
35	MP0001501_abnormal_sleep_pattern	1.63739863
36	MP0002735_abnormal_chemical_nociception	1.62123181
37	MP0005645_abnormal_hypothalamus_physiol	1.60506779
38	MP0000427_abnormal_hair_cycle	1.54855730
39	MP0000383_abnormal_hair_follicle	1.51017353
40	MP0000372_irregular_coat_pigmentation	1.50971688
41	MP0001486_abnormal_startle_reflex	1.49444751
42	MP0004147_increased_porphyrin_level	1.45851773
43	MP0002160_abnormal_reproductive_system	1.43799234
44	MP0000631_abnormal_neuroendocrine_gland	1.39282108
45	MP0002572_abnormal_emotion/affect_behav	1.34870976
46	MP0002928_abnormal_bile_duct	1.32833001
47	MP0005389_reproductive_system_phenotype	1.30934974
48	MP0002064_seizures	1.26940585
49	MP0002277_abnormal_respiratory_mucosa	1.26879524
50	MP0001970_abnormal_pain_threshold	1.26798585
51	MP0010386_abnormal_urinary_bladder	1.26761554
52	MP0002557_abnormal_social/conspecific_i	1.26082304
53	MP0002938_white_spotting	1.24715091
54	MP0001529_abnormal_vocalization	1.18910333
55	MP0003011_delayed_dark_adaptation	1.18674751
56	MP0005084_abnormal_gallbladder_morpholo	1.18541573
57	MP0008789_abnormal_olfactory_epithelium	1.18479026
58	MP0005174_abnormal_tail_pigmentation	1.18137125
59	MP0004742_abnormal_vestibular_system	1.17603272
60	MP0002733_abnormal_thermal_nociception	1.12531602
61	MP0002909_abnormal_adrenal_gland	1.11942252
62	MP0002067_abnormal_sensory_capabilities	1.10625947
63	MP0002734_abnormal_mechanical_nocicepti	1.06648141
64	MP0003635_abnormal_synaptic_transmissio	1.06026370
65	MP0004924_abnormal_behavior	1.03669480
66	MP0005386_behavior/neurological_phenoty	1.03669480
67	MP0005195_abnormal_posterior_eye	1.01273964
68	MP0002063_abnormal_learning/memory/cond	1.00417155
69	MP0001919_abnormal_reproductive_system	0.96646385
70	MP0003698_abnormal_male_reproductive	0.96587239
71	MP0001324_abnormal_eye_pigmentation	0.96141149
72	MP0001905_abnormal_dopamine_level	0.94459787
73	MP0005075_abnormal_melanosome_morpholog	0.93611849
74	MP0000026_abnormal_inner_ear	0.92979306
75	MP0002234_abnormal_pharynx_morphology	0.92317193
76	MP0005410_abnormal_fertilization	0.91945625
77	MP0005423_abnormal_somatic_nervous	0.91563830
78	MP0005083_abnormal_biliary_tract	0.91436035
79	MP0002229_neurodegeneration	0.91075707
80	MP0001963_abnormal_hearing_physiology	0.87607344
81	MP0005085_abnormal_gallbladder_physiolo	0.86977711
82	MP0003718_maternal_effect	0.85178273
83	MP0004145_abnormal_muscle_electrophysio	0.85129683
84	MP0001929_abnormal_gametogenesis	0.84927119
85	MP0002752_abnormal_somatic_nervous	0.84555559
86	MP0001502_abnormal_circadian_rhythm	0.83377461
87	MP0002095_abnormal_skin_pigmentation	0.80417121
88	MP0000230_abnormal_systemic_arterial	0.80030844
89	MP0000538_abnormal_urinary_bladder	0.79630112
90	MP0008995_early_reproductive_senescence	0.77839055
91	MP0002138_abnormal_hepatobiliary_system	0.77436481
92	MP0001765_abnormal_ion_homeostasis	0.74677006
93	MP0004019_abnormal_vitamin_homeostasis	0.73686243
94	MP0003890_abnormal_embryonic-extraembry	0.73306372
95	MP0005394_taste/olfaction_phenotype	0.72369696
96	MP0005499_abnormal_olfactory_system	0.72369696
97	MP0003283_abnormal_digestive_organ	0.71874340
98	MP0008775_abnormal_heart_ventricle	0.71589037
99	MP0009780_abnormal_chondrocyte_physiolo	0.70769601
100	MP0008058_abnormal_DNA_repair	0.70719117

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium morphology (HP:0005938)	5.90901536
2	Abnormal respiratory epithelium morphology (HP:0012253)	5.90901536
3	Absent/shortened dynein arms (HP:0200106)	5.79251820
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.79251820
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.52157957
6	Abnormal ciliary motility (HP:0012262)	5.44807970
7	Abnormal respiratory motile cilium physiology (HP:0012261)	5.29426754
8	Pancreatic cysts (HP:0001737)	4.98316130
9	Pancreatic fibrosis (HP:0100732)	4.83916253
10	Rhinitis (HP:0012384)	4.68912180
11	True hermaphroditism (HP:0010459)	4.65996522
12	Abnormality of midbrain morphology (HP:0002418)	4.54965998
13	Molar tooth sign on MRI (HP:0002419)	4.54965998
14	Nephronophthisis (HP:0000090)	4.30341259
15	Abnormality of the renal medulla (HP:0100957)	3.68443019
16	Cystic liver disease (HP:0006706)	3.57021325
17	Congenital stationary night blindness (HP:0007642)	3.51884651
18	Bronchiectasis (HP:0002110)	3.48730687
19	Chronic bronchitis (HP:0004469)	3.38895499
20	Chronic hepatic failure (HP:0100626)	3.36621809
21	Medial flaring of the eyebrow (HP:0010747)	3.34910478
22	Abnormality of the renal cortex (HP:0011035)	3.12044914
23	Tubular atrophy (HP:0000092)	2.85625817
24	Gait imbalance (HP:0002141)	2.77779115
25	Hyperventilation (HP:0002883)	2.72808682
26	Congenital hepatic fibrosis (HP:0002612)	2.69374275
27	Occipital encephalocele (HP:0002085)	2.69246689
28	Anencephaly (HP:0002323)	2.66711734
29	Congenital primary aphakia (HP:0007707)	2.66509899
30	Sclerocornea (HP:0000647)	2.62887150
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.62655767
32	Type II lissencephaly (HP:0007260)	2.60016590
33	Postaxial foot polydactyly (HP:0001830)	2.59420638
34	Attenuation of retinal blood vessels (HP:0007843)	2.57747737
35	Nephrogenic diabetes insipidus (HP:0009806)	2.51474234
36	Abnormal drinking behavior (HP:0030082)	2.50891948
37	Polydipsia (HP:0001959)	2.50891948
38	Furrowed tongue (HP:0000221)	2.44912227
39	Chronic sinusitis (HP:0011109)	2.40086128
40	Decreased circulating renin level (HP:0003351)	2.39095057
41	Male pseudohermaphroditism (HP:0000037)	2.38528857
42	Abolished electroretinogram (ERG) (HP:0000550)	2.34319249
43	Bile duct proliferation (HP:0001408)	2.33802472
44	Abnormal biliary tract physiology (HP:0012439)	2.33802472
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.33697708
46	Decreased central vision (HP:0007663)	2.16425218
47	Gaze-evoked nystagmus (HP:0000640)	2.14266282
48	Genital tract atresia (HP:0001827)	2.12334240
49	Congenital, generalized hypertrichosis (HP:0004540)	2.10579120
50	Polyuria (HP:0000103)	2.09605510
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.08503212
52	Vaginal atresia (HP:0000148)	2.07200085
53	Broad-based gait (HP:0002136)	2.04171896
54	Progressive cerebellar ataxia (HP:0002073)	2.02900653
55	Postaxial hand polydactyly (HP:0001162)	2.02302033
56	Large for gestational age (HP:0001520)	1.99670986
57	Asplenia (HP:0001746)	1.98827352
58	Nasal polyposis (HP:0100582)	1.97060766
59	Lissencephaly (HP:0001339)	1.94186406
60	Inability to walk (HP:0002540)	1.94128515
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.93844068
62	Pendular nystagmus (HP:0012043)	1.92091772
63	Bony spicule pigmentary retinopathy (HP:0007737)	1.90489906
64	Recurrent sinusitis (HP:0011108)	1.90331733
65	Keratoconus (HP:0000563)	1.89889343
66	Increased corneal curvature (HP:0100692)	1.89889343
67	Infertility (HP:0000789)	1.89578904
68	Bronchitis (HP:0012387)	1.88611009
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87754155
70	Abnormality of alanine metabolism (HP:0010916)	1.87754155
71	Hyperalaninemia (HP:0003348)	1.87754155
72	Poor coordination (HP:0002370)	1.86102200
73	Preaxial hand polydactyly (HP:0001177)	1.84552418
74	Tubulointerstitial nephritis (HP:0001970)	1.84469759
75	Absent speech (HP:0001344)	1.83973679
76	Renal cortical cysts (HP:0000803)	1.83558087
77	Retinitis pigmentosa (HP:0000510)	1.76385040
78	Progressive inability to walk (HP:0002505)	1.76180029
79	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.75534902
80	Protruding tongue (HP:0010808)	1.75373490
81	Oculomotor apraxia (HP:0000657)	1.74477664
82	Genetic anticipation (HP:0003743)	1.73027509
83	Cerebellar dysplasia (HP:0007033)	1.72255742
84	Hypothermia (HP:0002045)	1.71945828
85	Stomach cancer (HP:0012126)	1.71292927
86	Mitochondrial inheritance (HP:0001427)	1.70521844
87	Chronic otitis media (HP:0000389)	1.69619698
88	Concave nail (HP:0001598)	1.67707790
89	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.67423813
90	Abnormality of renin-angiotensin system (HP:0000847)	1.66903642
91	Increased CSF lactate (HP:0002490)	1.66571653
92	Tubulointerstitial abnormality (HP:0001969)	1.65658047
93	Acute necrotizing encephalopathy (HP:0006965)	1.64475933
94	Abnormality of the pons (HP:0007361)	1.62409838
95	Congenital sensorineural hearing impairment (HP:0008527)	1.62044322
96	Abnormal urine output (HP:0012590)	1.62033981
97	Febrile seizures (HP:0002373)	1.61108494
98	Hypoplasia of the pons (HP:0012110)	1.59097329
99	Optic disc pallor (HP:0000543)	1.57689916
100	Hemiparesis (HP:0001269)	1.55297564

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.98680552
2	BMPR1B	3.34271415
3	MAPK15	3.16255677
4	ADRBK2	3.13208134
5	ACVR1B	2.75665804
6	MAP4K2	2.60700615
7	ZAK	2.44271510
8	TLK1	2.37215237
9	GRK1	2.37044188
10	WNK3	2.36455436
11	CASK	2.18434800
12	NUAK1	2.16226257
13	WNK4	2.06030976
14	INSRR	1.99337322
15	MAPK13	1.96589294
16	PINK1	1.96117603
17	TAOK3	1.90566646
18	TXK	1.68074816
19	MST4	1.55311645
20	OXSR1	1.52271921
21	DAPK2	1.49707534
22	MAP3K4	1.48545103
23	MAPKAPK3	1.36250916
24	ADRBK1	1.28107929
25	TNIK	1.26107397
26	TRIM28	1.20676796
27	PAK3	1.20226022
28	PNCK	1.19571498
29	STK39	1.18979318
30	NME1	1.13014036
31	CAMKK2	1.12417895
32	MARK1	1.10140837
33	MKNK2	1.10098079
34	DYRK2	1.06740551
35	PTK2B	1.03939558
36	TGFBR1	1.03518909
37	PRKCE	0.95118567
38	MAP2K7	0.88681755
39	PRKCG	0.87623029
40	VRK1	0.85828742
41	NTRK3	0.84787447
42	PLK2	0.80423726
43	MUSK	0.79720283
44	STK16	0.78833467
45	MAP2K6	0.76960115
46	STK38L	0.75980201
47	PHKG2	0.74459391
48	PHKG1	0.74459391
49	BRSK2	0.70681013
50	BCR	0.67493661
51	PRKCQ	0.66679883
52	PRKCI	0.64741362
53	IKBKB	0.63932941
54	TIE1	0.63747081
55	TEC	0.61574932
56	EPHA4	0.59716521
57	BCKDK	0.58824256
58	CSNK1G2	0.58231390
59	CAMK2A	0.56794758
60	FGFR2	0.56732759
61	PIK3CA	0.56583340
62	ERBB3	0.54676397
63	CAMK1	0.52782156
64	CHUK	0.51508714
65	IRAK1	0.51486455
66	AKT3	0.49765948
67	PKN1	0.49505648
68	PRKACA	0.49113608
69	RPS6KA5	0.47356096
70	ITK	0.46326640
71	EPHA3	0.45333412
72	CSNK1G1	0.44849237
73	CSNK1G3	0.41786503
74	NTRK2	0.41557599
75	MAPKAPK5	0.41552387
76	KIT	0.41269885
77	NLK	0.40061670
78	GRK7	0.39613902
79	CSNK1A1	0.38942732
80	FER	0.38535189
81	STK11	0.38340195
82	PRKCA	0.36650162
83	ERBB2	0.35584867
84	NEK2	0.35171852
85	MAP3K7	0.34945040
86	PRKCZ	0.34908278
87	CSNK1A1L	0.34866591
88	CAMKK1	0.33950361
89	PRKAA2	0.33549790
90	TNK2	0.33337830
91	CCNB1	0.33019003
92	SGK2	0.32936491
93	DYRK1A	0.31746842
94	PRKAA1	0.31358133
95	MKNK1	0.31151690
96	PRKG1	0.30166387
97	TRPM7	0.29514550
98	PLK3	0.29427381
99	CSNK1D	0.28837987
100	MAP2K1	0.27618768

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.89602855
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.73927885
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.47160066
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.37961741
5	Caffeine metabolism_Homo sapiens_hsa00232	2.35617062
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30824702
7	Nicotine addiction_Homo sapiens_hsa05033	2.28499466
8	Butanoate metabolism_Homo sapiens_hsa00650	2.18429773
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.17479908
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09911180
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03479372
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00521778
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97096077
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.96898104
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.87460482
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.85368325
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.82005450
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.73387377
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.72553418
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.70898256
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.69783335
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.62915923
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.62414053
24	Taste transduction_Homo sapiens_hsa04742	1.59186098
25	Homologous recombination_Homo sapiens_hsa03440	1.57666776
26	Huntingtons disease_Homo sapiens_hsa05016	1.51650981
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.51506442
28	Protein export_Homo sapiens_hsa03060	1.48069786
29	Olfactory transduction_Homo sapiens_hsa04740	1.45870507
30	Histidine metabolism_Homo sapiens_hsa00340	1.43633412
31	Parkinsons disease_Homo sapiens_hsa05012	1.38591025
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38235689
33	Basal transcription factors_Homo sapiens_hsa03022	1.37902123
34	ABC transporters_Homo sapiens_hsa02010	1.35223317
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.32165714
36	RNA polymerase_Homo sapiens_hsa03020	1.32140710
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.29941064
38	Peroxisome_Homo sapiens_hsa04146	1.27889132
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24835465
40	Morphine addiction_Homo sapiens_hsa05032	1.23975063
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.21791246
42	Retinol metabolism_Homo sapiens_hsa00830	1.21589152
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.09483840
44	Serotonergic synapse_Homo sapiens_hsa04726	1.09417918
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08839963
46	Propanoate metabolism_Homo sapiens_hsa00640	1.07640778
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07618036
48	Cardiac muscle contraction_Homo sapiens_hsa04260	1.05665684
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01311139
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99031493
51	Circadian entrainment_Homo sapiens_hsa04713	0.95239721
52	Insulin secretion_Homo sapiens_hsa04911	0.94787847
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.93604952
54	GABAergic synapse_Homo sapiens_hsa04727	0.92770073
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.90637990
56	Alzheimers disease_Homo sapiens_hsa05010	0.86595962
57	Salivary secretion_Homo sapiens_hsa04970	0.86101432
58	RNA degradation_Homo sapiens_hsa03018	0.86067140
59	Regulation of autophagy_Homo sapiens_hsa04140	0.84914467
60	Asthma_Homo sapiens_hsa05310	0.84306278
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83716455
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76021399
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.74326874
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70482475
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70064277
66	Circadian rhythm_Homo sapiens_hsa04710	0.68659492
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.66400479
68	One carbon pool by folate_Homo sapiens_hsa00670	0.63210933
69	Purine metabolism_Homo sapiens_hsa00230	0.60801589
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.60342526
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59823977
72	Metabolic pathways_Homo sapiens_hsa01100	0.59813230
73	Graft-versus-host disease_Homo sapiens_hsa05332	0.59491074
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.53507177
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50716185
76	Fatty acid degradation_Homo sapiens_hsa00071	0.49727389
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49243516
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49014446
79	Cocaine addiction_Homo sapiens_hsa05030	0.48193861
80	Allograft rejection_Homo sapiens_hsa05330	0.47349236
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47244315
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46443468
83	Glutathione metabolism_Homo sapiens_hsa00480	0.45062652
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.44641786
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43779660
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42283737
87	Amphetamine addiction_Homo sapiens_hsa05031	0.40831563
88	Mineral absorption_Homo sapiens_hsa04978	0.40014005
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39808700
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39093050
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.38598202
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.35987866
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.34829534
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.33126675
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32994827
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.31644306
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.31568278
98	Pyrimidine metabolism_Homo sapiens_hsa00240	0.31406378
99	Sulfur metabolism_Homo sapiens_hsa00920	0.31092459
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.30900188

C2ORF81

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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