ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cholesterol esterification (GO:0010872)	6.68116273
2	plasma lipoprotein particle assembly (GO:0034377)	6.20611391
3	very-low-density lipoprotein particle assembly (GO:0034379)	6.14293652
4	protein-lipid complex remodeling (GO:0034368)	5.75311029
5	macromolecular complex remodeling (GO:0034367)	5.75311029
6	plasma lipoprotein particle remodeling (GO:0034369)	5.75311029
7	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.68551944
8	high-density lipoprotein particle remodeling (GO:0034375)	5.67605550
9	protein-lipid complex assembly (GO:0065005)	5.66166902
10	negative regulation of fibrinolysis (GO:0051918)	5.54512943
11	low-density lipoprotein particle remodeling (GO:0034374)	5.47158542
12	phospholipid efflux (GO:0033700)	5.42181708
13	cholesterol efflux (GO:0033344)	5.35278919
14	negative regulation of cholesterol transport (GO:0032375)	5.25418976
15	negative regulation of sterol transport (GO:0032372)	5.25418976
16	protein carboxylation (GO:0018214)	5.20718355
17	peptidyl-glutamic acid carboxylation (GO:0017187)	5.20718355
18	reverse cholesterol transport (GO:0043691)	5.19300909
19	plasma lipoprotein particle organization (GO:0071827)	4.92558733
20	regulation of fibrinolysis (GO:0051917)	4.91744898
21	plasma lipoprotein particle clearance (GO:0034381)	4.90811408
22	protein-lipid complex subunit organization (GO:0071825)	4.70622506
23	regulation of bile acid biosynthetic process (GO:0070857)	4.63830130
24	regulation of cholesterol homeostasis (GO:2000188)	4.40344983
25	neurotransmitter-gated ion channel clustering (GO:0072578)	4.38270908
26	regulation of plasminogen activation (GO:0010755)	4.32906961
27	regulation of cholesterol biosynthetic process (GO:0045540)	4.32666912
28	intestinal cholesterol absorption (GO:0030299)	4.24684251
29	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.07093233
30	L-phenylalanine catabolic process (GO:0006559)	4.07093233
31	proline metabolic process (GO:0006560)	4.05860371
32	central nervous system myelination (GO:0022010)	4.05101531
33	axon ensheathment in central nervous system (GO:0032291)	4.05101531
34	L-phenylalanine metabolic process (GO:0006558)	4.04191640
35	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.04191640
36	positive regulation of fatty acid biosynthetic process (GO:0045723)	4.04177810
37	positive regulation of triglyceride lipase activity (GO:0061365)	4.04151480
38	positive regulation of lipoprotein lipase activity (GO:0051006)	4.04151480
39	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.01738001
40	lung epithelium development (GO:0060428)	3.99182401
41	regulation of protein activation cascade (GO:2000257)	3.95508399
42	regulation of complement activation (GO:0030449)	3.88792357
43	positive regulation of steroid metabolic process (GO:0045940)	3.87146096
44	regulation of apoptotic cell clearance (GO:2000425)	3.81197096
45	negative regulation of lipase activity (GO:0060192)	3.74473482
46	glutamate metabolic process (GO:0006536)	3.60351257
47	cellular sodium ion homeostasis (GO:0006883)	3.54842809
48	regulation of cholesterol metabolic process (GO:0090181)	3.43764495
49	diacylglycerol metabolic process (GO:0046339)	3.42139630
50	positive regulation of synapse maturation (GO:0090129)	3.42110463
51	acylglycerol homeostasis (GO:0055090)	3.40126400
52	triglyceride homeostasis (GO:0070328)	3.40126400
53	lipoprotein metabolic process (GO:0042157)	3.37593414
54	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.34524415
55	blood coagulation, intrinsic pathway (GO:0007597)	3.23802865
56	fibrinolysis (GO:0042730)	3.23603220
57	intestinal absorption (GO:0050892)	3.20577695
58	positive regulation of dendritic spine development (GO:0060999)	3.18876418
59	negative regulation of blood coagulation (GO:0030195)	3.17379006
60	negative regulation of hemostasis (GO:1900047)	3.17379006
61	regulation of extracellular matrix disassembly (GO:0010715)	3.15448213
62	sterol transport (GO:0015918)	3.15409097
63	cholesterol transport (GO:0030301)	3.15409097
64	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.14778450
65	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.10470953
66	negative regulation of lipid transport (GO:0032369)	3.08982317
67	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.08537450
68	cholesterol homeostasis (GO:0042632)	3.07002232
69	regulation of extracellular matrix organization (GO:1903053)	3.06485003
70	positive regulation of extracellular matrix organization (GO:1903055)	3.01240944
71	glutamate secretion (GO:0014047)	3.01197094
72	sterol homeostasis (GO:0055092)	3.00905138
73	negative regulation of sodium ion transport (GO:0010766)	2.94035150
74	regulation of glycogen (starch) synthase activity (GO:2000465)	2.92536070
75	regulation of lipoprotein particle clearance (GO:0010984)	2.91145559
76	sodium ion export (GO:0071436)	2.90015713
77	regulation of fatty acid biosynthetic process (GO:0042304)	2.88512618
78	complement activation, alternative pathway (GO:0006957)	2.88340358
79	synaptic vesicle exocytosis (GO:0016079)	2.87244662
80	cellular potassium ion homeostasis (GO:0030007)	2.87014164
81	regulation of synapse maturation (GO:0090128)	2.86986702
82	negative regulation of coagulation (GO:0050819)	2.85662521
83	sodium ion homeostasis (GO:0055078)	2.84203830
84	C4-dicarboxylate transport (GO:0015740)	2.83287348
85	vitamin transmembrane transport (GO:0035461)	2.82355344
86	positive regulation of lipid catabolic process (GO:0050996)	2.82044784
87	vocalization behavior (GO:0071625)	2.81201034
88	cellular zinc ion homeostasis (GO:0006882)	2.78298118
89	cell-cell junction maintenance (GO:0045217)	2.77720491
90	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.76331336
91	drinking behavior (GO:0042756)	2.72694701
92	proline biosynthetic process (GO:0006561)	2.72373158
93	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.71091077
94	acute-phase response (GO:0006953)	2.69433057
95	short-term memory (GO:0007614)	2.66830568
96	negative regulation of wound healing (GO:0061045)	2.65624198
97	layer formation in cerebral cortex (GO:0021819)	2.64958726
98	artery smooth muscle contraction (GO:0014824)	2.64293334
99	amino acid import (GO:0043090)	2.61644892
100	dicarboxylic acid biosynthetic process (GO:0043650)	2.59326065

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.32016786
2	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.73007675
3	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	3.26114018
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.11024342
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.80519707
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.55188694
7	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.53914955
8	* LXR_22292898_ChIP-Seq_THP-1_Human	2.51897241
9	DROSHA_22980978_ChIP-Seq_HELA_Human	2.40027847
10	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.35922495
11	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.35744395
12	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.32219725
13	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.16931403
14	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.16193530
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.10030032
16	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.01839754
17	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.95967563
18	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.94879870
19	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.87710658
20	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.85146078
21	KDM2B_26808549_Chip-Seq_K562_Human	1.81609488
22	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.78821091
23	CTCF_27219007_Chip-Seq_Bcells_Human	1.78011698
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.77575617
25	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.77417619
26	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.76250534
27	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.74320587
28	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.73911201
29	ZNF263_19887448_ChIP-Seq_K562_Human	1.69729467
30	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.69470598
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.66431155
32	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.64158373
33	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.62950652
34	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.61233759
35	P68_20966046_ChIP-Seq_HELA_Human	1.61210388
36	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.60292838
37	SMC4_20622854_ChIP-Seq_HELA_Human	1.59357284
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.55560673
39	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.53154623
40	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.48498713
41	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.48129432
42	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.48129432
43	RACK7_27058665_Chip-Seq_MCF-7_Human	1.45527171
44	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.42857797
45	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.41789817
46	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.40847325
47	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.40278045
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.39782212
49	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.39170514
50	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.37731962
51	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.37434448
52	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.33358015
53	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31976774
54	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.31328114
55	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.30675070
56	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.25952726
57	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.25538167
58	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.24531138
59	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.21077165
60	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.19292348
61	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.17757677
62	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.16869047
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16545883
64	SA1_27219007_Chip-Seq_Bcells_Human	1.16018148
65	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.15954841
66	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.15750787
67	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14013820
68	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.12658789
69	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.12647185
70	CREB1_26743006_Chip-Seq_LNCaP_Human	1.12604492
71	OCT4_19829295_ChIP-Seq_ESCs_Human	1.11700634
72	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.10958252
73	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.10030496
74	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.09073593
75	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.08555828
76	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.08532315
77	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.08275488
78	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.07807893
79	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.07393125
80	EZH2_22144423_ChIP-Seq_EOC_Human	1.06608766
81	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.05898581
82	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.03886486
83	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.03380780
84	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.03270036
85	BCOR_27268052_Chip-Seq_Bcells_Human	1.02638558
86	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.00822457
87	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.00769946
88	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.00611637
89	CLOCK_20551151_ChIP-Seq_293T_Human	1.00325625
90	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.00281875
91	TP53_22127205_ChIP-Seq_IMR90_Human	1.00248608
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99186322
93	TP63_22573176_ChIP-Seq_HFKS_Human	0.98068022
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.98016923
95	MYC_19915707_ChIP-ChIP_AK7_Human	0.97482466
96	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.96826268
97	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96816095
98	KLF4_19829295_ChIP-Seq_ESCs_Human	0.95771468
99	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.94138140
100	PHF8_20622854_ChIP-Seq_HELA_Human	0.92719526

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.72744559
2	MP0002139_abnormal_hepatobiliary_system	4.96052580
3	MP0005365_abnormal_bile_salt	4.32360040
4	MP0000566_synostosis	3.78455677
5	MP0003122_maternal_imprinting	3.58755195
6	MP0003195_calcinosis	3.17470674
7	MP0010329_abnormal_lipoprotein_level	3.12806873
8	MP0004859_abnormal_synaptic_plasticity	2.90371206
9	MP0009840_abnormal_foam_cell	2.79929912
10	MP0001666_abnormal_nutrient_absorption	2.76126105
11	MP0005085_abnormal_gallbladder_physiolo	2.54490849
12	MP0004270_analgesia	2.54311689
13	MP0003879_abnormal_hair_cell	2.48305102
14	MP0009780_abnormal_chondrocyte_physiolo	2.45212611
15	MP0003329_amyloid_beta_deposits	2.44047381
16	MP0003123_paternal_imprinting	2.33985381
17	MP0002089_abnormal_postnatal_growth/wei	2.27475843
18	MP0003172_abnormal_lysosome_physiology	2.26621466
19	MP0005423_abnormal_somatic_nervous	2.21945295
20	MP0008875_abnormal_xenobiotic_pharmacok	2.13339794
21	MP0002064_seizures	2.10722097
22	MP0003880_abnormal_central_pattern	1.97383813
23	MP0003635_abnormal_synaptic_transmissio	1.87924295
24	MP0003868_abnormal_feces_composition	1.84843979
25	MP0005167_abnormal_blood-brain_barrier	1.79227995
26	MP0005646_abnormal_pituitary_gland	1.73100218
27	MP0000920_abnormal_myelination	1.66419796
28	MP0001486_abnormal_startle_reflex	1.66172419
29	MP0000604_amyloidosis	1.60723210
30	MP0005409_darkened_coat_color	1.59646346
31	MP0003690_abnormal_glial_cell	1.57015576
32	MP0002063_abnormal_learning/memory/cond	1.54432311
33	MP0005332_abnormal_amino_acid	1.42808788
34	MP0005451_abnormal_body_composition	1.41102202
35	MP0002572_abnormal_emotion/affect_behav	1.40076991
36	MP0002118_abnormal_lipid_homeostasis	1.39962716
37	MP0003252_abnormal_bile_duct	1.38040615
38	MP0002272_abnormal_nervous_system	1.37535579
39	MP0009745_abnormal_behavioral_response	1.30883041
40	MP0002876_abnormal_thyroid_physiology	1.30217554
41	MP0002734_abnormal_mechanical_nocicepti	1.30111029
42	MP0004264_abnormal_extraembryonic_tissu	1.29313388
43	MP0008569_lethality_at_weaning	1.23638577
44	MP0002735_abnormal_chemical_nociception	1.22876213
45	MP0003633_abnormal_nervous_system	1.22092590
46	MP0002909_abnormal_adrenal_gland	1.18456804
47	MP0005058_abnormal_lysosome_morphology	1.16942799
48	MP0000609_abnormal_liver_physiology	1.09326127
49	MP0003631_nervous_system_phenotype	1.08636920
50	MP0004019_abnormal_vitamin_homeostasis	1.08380134
51	MP0009046_muscle_twitch	1.06940145
52	MP0005377_hearing/vestibular/ear_phenot	1.05299381
53	MP0003878_abnormal_ear_physiology	1.05299381
54	MP0003632_abnormal_nervous_system	1.04505118
55	MP0000639_abnormal_adrenal_gland	1.02242301
56	MP0001501_abnormal_sleep_pattern	0.99761928
57	MP0003191_abnormal_cellular_cholesterol	0.98311407
58	MP0002557_abnormal_social/conspecific_i	0.96613074
59	MP0004742_abnormal_vestibular_system	0.94647628
60	MP0003634_abnormal_glial_cell	0.93568066
61	MP0001970_abnormal_pain_threshold	0.92550906
62	MP0004885_abnormal_endolymph	0.92314433
63	MP0005670_abnormal_white_adipose	0.91451539
64	MP0001984_abnormal_olfaction	0.91297986
65	MP0002733_abnormal_thermal_nociception	0.89753183
66	MP0000003_abnormal_adipose_tissue	0.88747176
67	MP0005448_abnormal_energy_balance	0.85007807
68	MP0001968_abnormal_touch/_nociception	0.83994251
69	MP0003075_altered_response_to	0.82996456
70	MP0002249_abnormal_larynx_morphology	0.82123724
71	MP0003183_abnormal_peptide_metabolism	0.76125229
72	MP0005636_abnormal_mineral_homeostasis	0.75978877
73	MP0002971_abnormal_brown_adipose	0.75515700
74	MP0002066_abnormal_motor_capabilities/c	0.75379790
75	MP0005084_abnormal_gallbladder_morpholo	0.74414678
76	MP0001502_abnormal_circadian_rhythm	0.73526372
77	MP0002067_abnormal_sensory_capabilities	0.73211485
78	MP0002229_neurodegeneration	0.72712883
79	MP0001915_intracranial_hemorrhage	0.72109812
80	MP0003567_abnormal_fetal_cardiomyocyte	0.70481766
81	MP0002138_abnormal_hepatobiliary_system	0.70077579
82	MP0000955_abnormal_spinal_cord	0.69782327
83	MP0005551_abnormal_eye_electrophysiolog	0.67965860
84	MP0002882_abnormal_neuron_morphology	0.66447630
85	MP0002078_abnormal_glucose_homeostasis	0.66344539
86	MP0009643_abnormal_urine_homeostasis	0.65248841
87	MP0001765_abnormal_ion_homeostasis	0.64405475
88	MP0003953_abnormal_hormone_level	0.62315667
89	MP0001346_abnormal_lacrimal_gland	0.60972941
90	MP0001756_abnormal_urination	0.59848913
91	MP0009642_abnormal_blood_homeostasis	0.58080007
92	MP0003115_abnormal_respiratory_system	0.57989981
93	MP0005379_endocrine/exocrine_gland_phen	0.57098768
94	MP0004811_abnormal_neuron_physiology	0.56617212
95	MP0004130_abnormal_muscle_cell	0.56341887
96	MP0001299_abnormal_eye_distance/	0.55228366
97	MP0001963_abnormal_hearing_physiology	0.54935965
98	MP0002822_catalepsy	0.54737533
99	MP0009115_abnormal_fat_cell	0.54268684
100	MP0001764_abnormal_homeostasis	0.53553894

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	8.53147668
2	Joint hemorrhage (HP:0005261)	5.34286910
3	Prolonged partial thromboplastin time (HP:0003645)	5.04756380
4	Hypobetalipoproteinemia (HP:0003563)	4.96938534
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.76385871
6	Xanthomatosis (HP:0000991)	4.64639477
7	Hemorrhage of the eye (HP:0011885)	4.56654357
8	Complement deficiency (HP:0004431)	4.05141168
9	Hypercholesterolemia (HP:0003124)	3.71318218
10	Alacrima (HP:0000522)	3.65850511
11	Neurofibrillary tangles (HP:0002185)	3.55412495
12	Menstrual irregularities (HP:0000858)	3.53405738
13	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.47929402
14	Glomerulonephritis (HP:0000099)	3.45211691
15	Systemic lupus erythematosus (HP:0002725)	3.34950903
16	Hypolipoproteinemia (HP:0010981)	3.33966475
17	Abnormality of carpal bone ossification (HP:0006257)	3.31987958
18	Flat acetabular roof (HP:0003180)	3.30836922
19	Myokymia (HP:0002411)	3.18519101
20	Obstructive sleep apnea (HP:0002870)	3.15473743
21	Abnormality of complement system (HP:0005339)	3.02300572
22	Stridor (HP:0010307)	2.94211711
23	Growth hormone excess (HP:0000845)	2.82203081
24	Distal upper limb amyotrophy (HP:0007149)	2.80054928
25	Upper limb amyotrophy (HP:0009129)	2.80054928
26	Action tremor (HP:0002345)	2.78754211
27	Bronchomalacia (HP:0002780)	2.77050828
28	Cerebral inclusion bodies (HP:0100314)	2.75461602
29	Hand muscle atrophy (HP:0009130)	2.74957868
30	Mitral stenosis (HP:0001718)	2.74940954
31	Hypoalphalipoproteinemia (HP:0003233)	2.70659778
32	Abnormal ossification of hand bones (HP:0005921)	2.64983561
33	Menorrhagia (HP:0000132)	2.63074891
34	Abnormal hand bone ossification (HP:0010660)	2.57637485
35	Asymmetry of the thorax (HP:0001555)	2.57171130
36	Decreased lacrimation (HP:0000633)	2.52934560
37	Epiphyseal dysplasia (HP:0002656)	2.52205255
38	Vascular calcification (HP:0004934)	2.51231859
39	Abnormality of the common coagulation pathway (HP:0010990)	2.43605366
40	Late onset (HP:0003584)	2.37753807
41	Focal motor seizures (HP:0011153)	2.33805256
42	Hyperglycinemia (HP:0002154)	2.31029396
43	Purpura (HP:0000979)	2.30069433
44	Supranuclear gaze palsy (HP:0000605)	2.29600321
45	Diaphragmatic weakness (HP:0009113)	2.29239805
46	Hyperlipoproteinemia (HP:0010980)	2.28748467
47	Epileptic encephalopathy (HP:0200134)	2.28612864
48	Spontaneous abortion (HP:0005268)	2.27295873
49	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.24980749
50	Aplasia involving bones of the upper limbs (HP:0009823)	2.24655018
51	Aplasia of the phalanges of the hand (HP:0009802)	2.24655018
52	Aplasia involving bones of the extremities (HP:0009825)	2.24655018
53	Ankle clonus (HP:0011448)	2.24058627
54	Delayed CNS myelination (HP:0002188)	2.19949316
55	Facial shape deformation (HP:0011334)	2.18829925
56	Potter facies (HP:0002009)	2.18829925
57	Akinesia (HP:0002304)	2.15352991
58	Abnormality of binocular vision (HP:0011514)	2.11693490
59	Diplopia (HP:0000651)	2.11693490
60	Impaired pain sensation (HP:0007328)	2.10852751
61	Abnormality of pain sensation (HP:0010832)	2.10852751
62	Hypophosphatemic rickets (HP:0004912)	2.10507916
63	Focal seizures (HP:0007359)	2.08861952
64	Partial duplication of thumb phalanx (HP:0009944)	2.08724157
65	Epidermoid cyst (HP:0200040)	2.07558869
66	Acanthocytosis (HP:0001927)	2.07115060
67	Abnormality of the middle phalanges of the toes (HP:0010183)	2.06291207
68	Cardiovascular calcification (HP:0011915)	2.05590033
69	Bifid scrotum (HP:0000048)	2.02586652
70	Abnormal tarsal ossification (HP:0008369)	2.01988776
71	Neonatal death (HP:0003811)	2.01776378
72	Torticollis (HP:0000473)	2.00681969
73	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.97613016
74	Sleep apnea (HP:0010535)	1.94234951
75	Abnormality of the musculature of the hand (HP:0001421)	1.93341057
76	Small epiphyses (HP:0010585)	1.92905140
77	Conjugated hyperbilirubinemia (HP:0002908)	1.88032384
78	Intrahepatic cholestasis (HP:0001406)	1.87721533
79	Abnormality of serine family amino acid metabolism (HP:0010894)	1.85923364
80	Abnormality of glycine metabolism (HP:0010895)	1.85923364
81	Focal dystonia (HP:0004373)	1.85844769
82	Hydroxyprolinuria (HP:0003080)	1.84878771
83	Abnormality of proline metabolism (HP:0010907)	1.84878771
84	Neonatal short-limb short stature (HP:0008921)	1.84216174
85	Abnormality of the Achilles tendon (HP:0005109)	1.83872321
86	Amyloidosis (HP:0011034)	1.83748607
87	Confusion (HP:0001289)	1.83156778
88	Status epilepticus (HP:0002133)	1.82202720
89	Spinal cord compression (HP:0002176)	1.81970538
90	Megalencephaly (HP:0001355)	1.81753049
91	Craniofacial dystonia (HP:0012179)	1.81706317
92	Short femoral neck (HP:0100864)	1.77037003
93	Widely patent fontanelles and sutures (HP:0004492)	1.77032033
94	Dysmetria (HP:0001310)	1.76980729
95	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.76546378
96	Paraparesis (HP:0002385)	1.76210889
97	Fat malabsorption (HP:0002630)	1.71661929
98	Rickets (HP:0002748)	1.71525356
99	Nephritis (HP:0000123)	1.70862880
100	Lower limb asymmetry (HP:0100559)	1.68475116

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	5.65021926
2	EPHA4	3.93696517
3	ICK	3.06693203
4	TRIB3	3.00623065
5	NTRK3	2.91689380
6	TYRO3	2.91668554
7	RIPK1	2.91098276
8	CAMKK1	2.63701385
9	FGFR3	2.46335763
10	ERN1	2.36253044
11	CAMKK2	2.25088090
12	SIK2	2.04783488
13	PRKD3	1.98135684
14	FGFR2	1.87933858
15	SIK1	1.84314524
16	DAPK2	1.72435972
17	WNK4	1.64721574
18	CDK12	1.59209781
19	MAP3K11	1.54558406
20	DDR2	1.46111636
21	PDGFRA	1.45898913
22	PAK6	1.41892609
23	PKN2	1.37722213
24	LMTK2	1.37029801
25	NTRK2	1.36462676
26	EPHA2	1.34065130
27	NTRK1	1.31278478
28	MARK1	1.29227473
29	UHMK1	1.28804260
30	TNK2	1.26277073
31	MARK2	1.26085550
32	PIK3CA	1.24634723
33	DYRK1B	1.19272851
34	SGK223	1.17776680
35	SGK494	1.17776680
36	CDC42BPA	1.16588144
37	MINK1	1.15466979
38	RET	1.07646674
39	PDPK1	1.06281745
40	CAMK1D	1.04802337
41	SGK1	1.00649741
42	PRKCG	1.00261992
43	CAMK4	0.99525082
44	MST1R	0.94673850
45	PTK6	0.94007488
46	ALK	0.92796995
47	FGFR1	0.87977475
48	CAMK1	0.86406164
49	BMX	0.86003671
50	CASK	0.84899348
51	ERBB2	0.80906933
52	CDK5	0.80451980
53	MAPK11	0.79215431
54	MAP3K1	0.77926298
55	PHKG2	0.77212670
56	PHKG1	0.77212670
57	PRKG2	0.76841961
58	PRKCZ	0.75134432
59	MET	0.75014866
60	PDK1	0.74617899
61	SGK3	0.74017374
62	MAPK13	0.71899711
63	KSR2	0.67820982
64	EEF2K	0.64878544
65	MAP2K6	0.64708014
66	SGK2	0.62670769
67	DAPK1	0.62663371
68	CAMK2B	0.62441305
69	IRAK3	0.61702692
70	EPHB1	0.61355045
71	WNK1	0.61231060
72	PRKAA2	0.60017848
73	MAP3K7	0.57558665
74	CAMK1G	0.56381339
75	STK38	0.55344834
76	TAOK1	0.54690996
77	CDK15	0.54427473
78	GRK5	0.53195934
79	SMG1	0.52925264
80	CAMK2G	0.52452473
81	PTK2	0.50113849
82	RPS6KA3	0.50087210
83	CDK11A	0.50017017
84	CSNK1E	0.49513086
85	MAPK10	0.49439052
86	BRSK1	0.49299512
87	CDK18	0.48167135
88	PRKAA1	0.45852270
89	PRKD2	0.45264161
90	MAP3K2	0.45173550
91	CAMK2A	0.44883299
92	PRPF4B	0.44754962
93	SRC	0.43125930
94	LATS2	0.42594819
95	CAMK2D	0.40298004
96	CDK14	0.39747136
97	PRKCH	0.37553703
98	PRKACG	0.37343504
99	MAPK8	0.37084485
100	MTOR	0.32557771

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	3.59374414
2	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.44067555
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.93962443
4	Histidine metabolism_Homo sapiens_hsa00340	2.71164443
5	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.62364335
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.48006510
7	Fat digestion and absorption_Homo sapiens_hsa04975	2.23322258
8	Bile secretion_Homo sapiens_hsa04976	2.17250814
9	Arginine and proline metabolism_Homo sapiens_hsa00330	2.09098939
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.05389828
11	PPAR signaling pathway_Homo sapiens_hsa03320	2.02442657
12	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.95965910
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.84892668
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.84037811
15	Phenylalanine metabolism_Homo sapiens_hsa00360	1.82110160
16	Other glycan degradation_Homo sapiens_hsa00511	1.72162268
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71728857
18	Sulfur relay system_Homo sapiens_hsa04122	1.71005005
19	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.57646184
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.57037690
21	Fatty acid degradation_Homo sapiens_hsa00071	1.42516453
22	Nicotine addiction_Homo sapiens_hsa05033	1.34943487
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.32904090
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31673690
25	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.28056934
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.23661463
27	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.23384892
28	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.21257315
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.19825328
30	Long-term potentiation_Homo sapiens_hsa04720	1.18515408
31	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.17422801
32	ABC transporters_Homo sapiens_hsa02010	1.14331718
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.13458241
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10664055
35	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.09107960
36	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.03442222
37	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.02974823
38	Mineral absorption_Homo sapiens_hsa04978	1.02831737
39	Insulin secretion_Homo sapiens_hsa04911	1.02696217
40	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.02237287
41	Amphetamine addiction_Homo sapiens_hsa05031	1.01587503
42	GABAergic synapse_Homo sapiens_hsa04727	1.00553276
43	Prion diseases_Homo sapiens_hsa05020	0.99291040
44	Lysine degradation_Homo sapiens_hsa00310	0.98251502
45	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.97528707
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.96039888
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.94178771
48	Tyrosine metabolism_Homo sapiens_hsa00350	0.91122759
49	Butanoate metabolism_Homo sapiens_hsa00650	0.85432787
50	Sphingolipid metabolism_Homo sapiens_hsa00600	0.85129904
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.84967970
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.82002905
53	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.81931590
54	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.81154957
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78706989
56	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.76207443
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75822162
58	Retinol metabolism_Homo sapiens_hsa00830	0.73049558
59	Cocaine addiction_Homo sapiens_hsa05030	0.71573548
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69898864
61	Glucagon signaling pathway_Homo sapiens_hsa04922	0.68914501
62	Gastric acid secretion_Homo sapiens_hsa04971	0.67516355
63	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.66630341
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.66549082
65	Circadian entrainment_Homo sapiens_hsa04713	0.66237723
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.64247179
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63820344
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62859266
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.61938869
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61508317
71	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.58174904
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.57932527
73	Renin secretion_Homo sapiens_hsa04924	0.56424618
74	Sulfur metabolism_Homo sapiens_hsa00920	0.54760293
75	GnRH signaling pathway_Homo sapiens_hsa04912	0.54132899
76	Morphine addiction_Homo sapiens_hsa05032	0.53707770
77	Peroxisome_Homo sapiens_hsa04146	0.52678036
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52418845
79	Caffeine metabolism_Homo sapiens_hsa00232	0.48107875
80	Galactose metabolism_Homo sapiens_hsa00052	0.46652762
81	Salivary secretion_Homo sapiens_hsa04970	0.46573799
82	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.46319497
83	Carbon metabolism_Homo sapiens_hsa01200	0.45953744
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.44811226
85	Cholinergic synapse_Homo sapiens_hsa04725	0.44286960
86	Axon guidance_Homo sapiens_hsa04360	0.43075900
87	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.43014918
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42564116
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42416085
90	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.41329689
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.39284809
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.38252016
93	Estrogen signaling pathway_Homo sapiens_hsa04915	0.37993068
94	Insulin resistance_Homo sapiens_hsa04931	0.37907063
95	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37737082
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.37529037
97	Pancreatic secretion_Homo sapiens_hsa04972	0.36588651
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36089787
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.35977257
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.35490647

C2ORF82

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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