C2ORF88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.23834401
2neutrophil activation involved in immune response (GO:0002283)6.65432150
3protein neddylation (GO:0045116)6.09245172
4regulation of platelet aggregation (GO:0090330)5.87497570
5regulation of platelet activation (GO:0010543)5.31693149
6blood coagulation, intrinsic pathway (GO:0007597)5.15869923
7platelet aggregation (GO:0070527)4.88700678
8positive regulation of endothelial cell differentiation (GO:0045603)4.56755382
9negative regulation of norepinephrine secretion (GO:0010700)4.54662229
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.53026724
11adenosine receptor signaling pathway (GO:0001973)4.50435309
12regulation of lipoprotein metabolic process (GO:0050746)4.46606610
13positive regulation of mast cell activation (GO:0033005)4.42538537
14leukocyte migration involved in inflammatory response (GO:0002523)4.35393828
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.29779252
16negative regulation of homotypic cell-cell adhesion (GO:0034111)4.25921322
17negative regulation of thymocyte apoptotic process (GO:0070244)4.23979723
18angiogenesis involved in wound healing (GO:0060055)4.16663897
19regulation of integrin-mediated signaling pathway (GO:2001044)4.11816280
20negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.07685191
21negative regulation of platelet activation (GO:0010544)4.04953747
22neutrophil activation (GO:0042119)4.01817517
23regulation of integrin activation (GO:0033623)3.98945564
24megakaryocyte development (GO:0035855)3.98304639
25negative regulation of heart rate (GO:0010459)3.90945134
26purinergic nucleotide receptor signaling pathway (GO:0035590)3.87688176
27lipoxygenase pathway (GO:0019372)3.83921415
28regulation of Golgi to plasma membrane protein transport (GO:0042996)3.76641315
29platelet formation (GO:0030220)3.55323955
30low-density lipoprotein particle remodeling (GO:0034374)3.51735503
31positive regulation of cAMP-mediated signaling (GO:0043950)3.49185282
32homotypic cell-cell adhesion (GO:0034109)3.47536643
33granulocyte activation (GO:0036230)3.46415131
34platelet degranulation (GO:0002576)3.46220764
35positive regulation of Rho protein signal transduction (GO:0035025)3.40049436
36negative regulation of protein localization to cell surface (GO:2000009)3.39487411
37positive regulation of macrophage differentiation (GO:0045651)3.38653316
38platelet activation (GO:0030168)3.37322000
39positive regulation of systemic arterial blood pressure (GO:0003084)3.32079442
40regulation of homotypic cell-cell adhesion (GO:0034110)3.28702468
41negative regulation of heart contraction (GO:0045822)3.28426850
42regulation of MHC class II biosynthetic process (GO:0045346)3.27852267
43regulation of macrophage derived foam cell differentiation (GO:0010743)3.22576397
44positive regulation of granulocyte differentiation (GO:0030854)3.22406728
45polyamine biosynthetic process (GO:0006596)3.22393939
46positive regulation of blood coagulation (GO:0030194)3.18281089
47positive regulation of hemostasis (GO:1900048)3.18281089
48positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.13755024
49regulation of endothelial cell differentiation (GO:0045601)3.09954772
50negative regulation of appetite (GO:0032099)3.09224923
51negative regulation of response to food (GO:0032096)3.09224923
52purinergic receptor signaling pathway (GO:0035587)3.06740815
53autophagic vacuole fusion (GO:0000046)3.06025235
54regulation of memory T cell differentiation (GO:0043380)3.03288321
55regulation of mast cell activation (GO:0033003)3.03226227
56negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.02876753
57cyclooxygenase pathway (GO:0019371)3.02052093
58negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98158365
59negative regulation of T-helper cell differentiation (GO:0045623)2.98158365
60pyrimidine nucleoside catabolic process (GO:0046135)2.95889834
61fusion of sperm to egg plasma membrane (GO:0007342)2.94994226
62positive regulation of receptor recycling (GO:0001921)2.94475782
63mitochondrial calcium ion transport (GO:0006851)2.94115706
64high-density lipoprotein particle remodeling (GO:0034375)2.93972978
65G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.92574058
66termination of G-protein coupled receptor signaling pathway (GO:0038032)2.90328228
67negative regulation of T cell apoptotic process (GO:0070233)2.89780305
68peptide catabolic process (GO:0043171)2.88149775
69positive regulation of coagulation (GO:0050820)2.88149220
70regulation of blood coagulation (GO:0030193)2.84249988
71regulation of hemostasis (GO:1900046)2.84249988
72regulation of female receptivity (GO:0045924)2.82957568
73termination of signal transduction (GO:0023021)2.82387918
74negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.81362650
75regulation of regulatory T cell differentiation (GO:0045589)2.80968898
76beta-amyloid metabolic process (GO:0050435)2.80867938
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79469579
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.79165939
79leukocyte degranulation (GO:0043299)2.78692032
80regulation of mast cell degranulation (GO:0043304)2.77594612
81reverse cholesterol transport (GO:0043691)2.77540114
82regulation of norepinephrine secretion (GO:0014061)2.76298663
83phospholipid homeostasis (GO:0055091)2.75786902
84negative regulation of erythrocyte differentiation (GO:0045647)2.73496209
85negative regulation of neural precursor cell proliferation (GO:2000178)2.72901164
86regulation of mast cell activation involved in immune response (GO:0033006)2.70704561
87negative regulation of protein localization to plasma membrane (GO:1903077)2.70115606
88regulation of inositol phosphate biosynthetic process (GO:0010919)2.67353128
89negative regulation of calcium ion transport into cytosol (GO:0010523)2.66213876
90actin filament polymerization (GO:0030041)2.64422015
91definitive hemopoiesis (GO:0060216)2.64321551
92organelle membrane fusion (GO:0090174)2.63485478
93negative regulation of catecholamine secretion (GO:0033604)2.62972217
94positive regulation of mast cell degranulation (GO:0043306)2.62712552
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.62712552
96dendritic cell chemotaxis (GO:0002407)2.62096986
97phospholipid scrambling (GO:0017121)2.61725178
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59944346
99negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.57849784
100regulation of coagulation (GO:0050818)2.57235685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.09326911
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.98892161
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.44560010
4GATA1_19941826_ChIP-Seq_K562_Human3.07035537
5GATA1_22025678_ChIP-Seq_K562_Human2.97740254
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92843072
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92687968
8GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.90091388
9GATA2_19941826_ChIP-Seq_K562_Human2.70718291
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.53568256
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49929037
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46614972
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.38582931
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35003134
15GATA1_19941827_ChIP-Seq_MEL_Mouse2.31970925
16LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.27033337
17SPI1_23127762_ChIP-Seq_K562_Human2.19609293
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.15003448
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06955466
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95566830
21TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.90083357
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87901881
23EZH2_22144423_ChIP-Seq_EOC_Human1.80250218
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79493224
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79247902
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.78907410
27GATA1_22383799_ChIP-Seq_G1ME_Mouse1.76997582
28GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.74695687
29GBX2_23144817_ChIP-Seq_PC3_Human1.66776654
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66545459
31HTT_18923047_ChIP-ChIP_STHdh_Human1.64555034
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63650694
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63021751
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60438819
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58544944
36RUNX_20019798_ChIP-Seq_JUKART_Human1.55018818
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.53422135
38GATA1_19941827_ChIP-Seq_MEL86_Mouse1.45345727
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.44395935
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43089361
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.41594258
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40192988
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39627031
44KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.37702829
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35464936
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29519001
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29066188
48SALL4_22934838_ChIP-ChIP_CD34+_Human1.24052116
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22688991
50VDR_22108803_ChIP-Seq_LS180_Human1.22556887
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18800130
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18800130
53TAF15_26573619_Chip-Seq_HEK293_Human1.18714051
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.18069285
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16774098
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14809329
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.12657402
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12618304
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.11675257
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.11665243
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10043066
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.07827688
63* GATA4_25053715_ChIP-Seq_YYC3_Human1.03543160
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00497011
65MYB_26560356_Chip-Seq_TH2_Human0.99991115
66ETS1_22383799_ChIP-Seq_G1ME_Mouse0.99989922
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98452657
68LXR_22158963_ChIP-Seq_LIVER_Mouse0.96846202
69GATA3_27048872_Chip-Seq_THYMUS_Human0.96476633
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96217452
71GATA3_26560356_Chip-Seq_TH2_Human0.95623274
72NCOR1_26117541_ChIP-Seq_K562_Human0.95538635
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94316385
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92500321
75SPI1_23547873_ChIP-Seq_NB4_Human0.92393556
76SMAD4_21799915_ChIP-Seq_A2780_Human0.92249901
77SOX2_20726797_ChIP-Seq_SW620_Human0.92178780
78ESR1_20079471_ChIP-ChIP_T-47D_Human0.91809594
79OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91392360
80* CDX2_22108803_ChIP-Seq_LS180_Human0.91327688
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90149012
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89129446
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88751932
84SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87757771
85SMRT_27268052_Chip-Seq_Bcells_Human0.87493721
86BCAT_22108803_ChIP-Seq_LS180_Human0.87256875
87STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86328149
88P53_22387025_ChIP-Seq_ESCs_Mouse0.85985669
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.85278900
90CEBPB_22108803_ChIP-Seq_LS180_Human0.84640218
91LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84111075
92* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83816936
93IGF1R_20145208_ChIP-Seq_DFB_Human0.83653922
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83270234
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.82466744
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81927202
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81721974
98* OCT1_27270436_Chip-Seq_PROSTATE_Human0.81515415
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81199223
100* ER_23166858_ChIP-Seq_MCF-7_Human0.80880353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.59031883
2MP0008004_abnormal_stomach_pH5.32766203
3MP0003724_increased_susceptibility_to4.03535574
4MP0000465_gastrointestinal_hemorrhage3.67592878
5MP0004510_myositis2.62534860
6MP0003303_peritoneal_inflammation2.54940277
7MP0005083_abnormal_biliary_tract2.41255602
8MP0004084_abnormal_cardiac_muscle2.31259751
9MP0001835_abnormal_antigen_presentation2.30485235
10MP0004147_increased_porphyrin_level2.13991526
11MP0010155_abnormal_intestine_physiology2.12783894
12MP0000230_abnormal_systemic_arterial2.06793632
13MP0008775_abnormal_heart_ventricle1.85773764
14MP0005085_abnormal_gallbladder_physiolo1.82483807
15MP0000343_altered_response_to1.79220630
16MP0003656_abnormal_erythrocyte_physiolo1.78512135
17MP0004036_abnormal_muscle_relaxation1.75000679
18MP0003828_pulmonary_edema1.62379207
19MP0003866_abnormal_defecation1.60698515
20MP0003183_abnormal_peptide_metabolism1.58436770
21MP0010329_abnormal_lipoprotein_level1.56009785
22MP0004130_abnormal_muscle_cell1.55619325
23MP0002736_abnormal_nociception_after1.55201310
24MP0005167_abnormal_blood-brain_barrier1.53771607
25MP0005360_urolithiasis1.52043201
26MP0001663_abnormal_digestive_system1.50832976
27MP0008872_abnormal_physiological_respon1.49754216
28MP0003638_abnormal_response/metabolism_1.49455655
29MP0005671_abnormal_response_to1.49199199
30MP0005365_abnormal_bile_salt1.48380964
31MP0005397_hematopoietic_system_phenotyp1.47811544
32MP0001545_abnormal_hematopoietic_system1.47811544
33MP0005000_abnormal_immune_tolerance1.47646436
34MP0002148_abnormal_hypersensitivity_rea1.46953794
35MP0003879_abnormal_hair_cell1.44868328
36MP0003300_gastrointestinal_ulcer1.43932468
37MP0002398_abnormal_bone_marrow1.43102229
38MP0001851_eye_inflammation1.40787970
39MP0003566_abnormal_cell_adhesion1.37170560
40MP0001664_abnormal_digestion1.36841085
41MP0002132_abnormal_respiratory_system1.34952875
42MP0004484_altered_response_of1.33153248
43MP0003436_decreased_susceptibility_to1.32787235
44MP0005084_abnormal_gallbladder_morpholo1.32301459
45MP0000249_abnormal_blood_vessel1.32257486
46MP0000015_abnormal_ear_pigmentation1.31630344
47MP0001800_abnormal_humoral_immune1.29557502
48MP0002723_abnormal_immune_serum1.22412598
49MP0009764_decreased_sensitivity_to1.21048949
50MP0001765_abnormal_ion_homeostasis1.19996056
51MP0005410_abnormal_fertilization1.18081313
52MP0004947_skin_inflammation1.16484988
53MP0004215_abnormal_myocardial_fiber1.13476238
54MP0002452_abnormal_antigen_presenting1.12712896
55MP0009763_increased_sensitivity_to1.12515322
56MP0000689_abnormal_spleen_morphology1.08998475
57MP0001666_abnormal_nutrient_absorption1.05896121
58MP0005387_immune_system_phenotype1.05425941
59MP0001790_abnormal_immune_system1.05425941
60MP0005535_abnormal_body_temperature1.05411926
61MP0001845_abnormal_inflammatory_respons1.05349121
62MP0001533_abnormal_skeleton_physiology1.04972362
63MP0005646_abnormal_pituitary_gland1.03570971
64MP0002420_abnormal_adaptive_immunity1.01685133
65MP0002429_abnormal_blood_cell1.01297703
66MP0001819_abnormal_immune_cell1.00456047
67MP0009642_abnormal_blood_homeostasis0.99896780
68MP0006054_spinal_hemorrhage0.99439235
69MP0005025_abnormal_response_to0.99428960
70MP0005174_abnormal_tail_pigmentation0.97672050
71MP0002733_abnormal_thermal_nociception0.96475421
72MP0009765_abnormal_xenobiotic_induced0.96154230
73MP0002722_abnormal_immune_system0.95563043
74MP0002419_abnormal_innate_immunity0.95113642
75MP0003718_maternal_effect0.94307536
76MP0005058_abnormal_lysosome_morphology0.94236004
77MP0002118_abnormal_lipid_homeostasis0.94122788
78MP0005381_digestive/alimentary_phenotyp0.93866472
79MP0005409_darkened_coat_color0.93770000
80MP0005636_abnormal_mineral_homeostasis0.92381970
81MP0001968_abnormal_touch/_nociception0.90247513
82MP0000716_abnormal_immune_system0.90044736
83MP0008874_decreased_physiological_sensi0.88500591
84MP0000490_abnormal_crypts_of0.84785394
85MP0009697_abnormal_copulation0.84608374
86MP0005670_abnormal_white_adipose0.84530315
87MP0001544_abnormal_cardiovascular_syste0.83498738
88MP0005385_cardiovascular_system_phenoty0.83498738
89MP0002972_abnormal_cardiac_muscle0.81180178
90MP0001879_abnormal_lymphatic_vessel0.80937129
91MP0005666_abnormal_adipose_tissue0.80673168
92MP0005165_increased_susceptibility_to0.79573752
93MP0000685_abnormal_immune_system0.77641073
94MP0004883_abnormal_blood_vessel0.77626960
95MP0000858_altered_metastatic_potential0.75938322
96MP0009333_abnormal_splenocyte_physiolog0.74940372
97MP0002998_abnormal_bone_remodeling0.74702147
98MP0003763_abnormal_thymus_physiology0.74136766
99MP0006138_congestive_heart_failure0.73660109
100MP0003252_abnormal_bile_duct0.72353326

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)9.80374745
2Petechiae (HP:0000967)9.74752748
3Abnormal platelet volume (HP:0011876)9.68072868
4Purpura (HP:0000979)8.37097431
5Epistaxis (HP:0000421)7.34632082
6Gingival bleeding (HP:0000225)6.65214428
7Impaired platelet aggregation (HP:0003540)5.61074504
8Abnormal platelet function (HP:0011869)5.61074504
9Acanthocytosis (HP:0001927)5.14234408
10Poikilocytosis (HP:0004447)4.98306150
11Hyperlipoproteinemia (HP:0010980)4.78097189
12Spontaneous hematomas (HP:0007420)4.64907852
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.54109763
14Dyschromatopsia (HP:0007641)3.41926302
15Conjunctival telangiectasia (HP:0000524)3.25642286
16Abnormal pupillary function (HP:0007686)3.12530043
17Bruising susceptibility (HP:0000978)3.12040372
18Abnormality of the common coagulation pathway (HP:0010990)2.99505203
19Abnormality of the vasculature of the conjunctiva (HP:0008054)2.87724068
20Increased density of long bones (HP:0006392)2.87222438
21Paralysis (HP:0003470)2.69959412
22Abnormality of lateral ventricle (HP:0030047)2.53618475
23Nausea (HP:0002018)2.37363730
24Stomatitis (HP:0010280)2.28994926
25Xanthomatosis (HP:0000991)2.27514002
26Ileus (HP:0002595)2.23739258
27Joint swelling (HP:0001386)2.21452929
28Abnormality of macrophages (HP:0004311)2.21186088
29Polycythemia (HP:0001901)2.21010664
30Ventricular fibrillation (HP:0001663)2.20894451
31Encephalitis (HP:0002383)2.20654035
32Tinnitus (HP:0000360)2.18609128
33Abnormality of iron homeostasis (HP:0011031)2.17729837
34Abnormal auditory evoked potentials (HP:0006958)2.15176081
35Papillary thyroid carcinoma (HP:0002895)2.13359188
36Arterial thrombosis (HP:0004420)2.07775901
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03525785
38Eczematoid dermatitis (HP:0000976)2.03423101
39Abnormality of transition element cation homeostasis (HP:0011030)2.01985214
40Hyperthyroidism (HP:0000836)2.00929319
41Chronic obstructive pulmonary disease (HP:0006510)2.00811447
42Obstructive lung disease (HP:0006536)2.00811447
43Prolonged bleeding time (HP:0003010)11.0486178
44Increased mean platelet volume (HP:0011877)10.2518664
45Biliary tract neoplasm (HP:0100574)1.99407627
46Hepatosplenomegaly (HP:0001433)1.99332372
47Decreased central vision (HP:0007663)1.99063336
48Increased IgM level (HP:0003496)1.95271181
49Autoimmune hemolytic anemia (HP:0001890)1.90732214
50Generalized aminoaciduria (HP:0002909)1.90192475
51Joint hemorrhage (HP:0005261)1.87249405
52Upper limb muscle weakness (HP:0003484)1.83243808
53Chest pain (HP:0100749)1.82620193
54Spontaneous abortion (HP:0005268)1.79010587
55Episodic fever (HP:0001954)1.68423966
56Vertigo (HP:0002321)1.66986241
57Metabolic alkalosis (HP:0200114)1.64956108
58Thyroid-stimulating hormone excess (HP:0002925)1.64794953
59Hypophosphatemic rickets (HP:0004912)1.63574298
60Increased serum ferritin (HP:0003281)1.62587968
61Central scotoma (HP:0000603)1.62483695
62Congenital sensorineural hearing impairment (HP:0008527)1.60165032
63Inflammation of the large intestine (HP:0002037)1.56247093
64Tongue fasciculations (HP:0001308)1.55971646
65Cerebral hemorrhage (HP:0001342)1.55079530
66Muscle fibrillation (HP:0010546)1.54852588
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.54654552
68Myocardial infarction (HP:0001658)1.52416907
69Leukocytosis (HP:0001974)1.52315913
70Male infertility (HP:0003251)1.51483375
71Abnormality of the prostate (HP:0008775)1.48399595
72Abnormality of glutamine family amino acid metabolism (HP:0010902)1.48162970
73Recurrent abscess formation (HP:0002722)1.46865009
74Thyroid carcinoma (HP:0002890)1.46753982
75Thrombophlebitis (HP:0004418)1.45509632
76Chronic diarrhea (HP:0002028)1.45378105
77Neoplasm of the rectum (HP:0100743)1.44190772
78Microcytic anemia (HP:0001935)1.44185571
79Testicular neoplasm (HP:0010788)1.43441895
80Recurrent bacterial skin infections (HP:0005406)1.43279803
81Chronic otitis media (HP:0000389)1.42221399
82Granulocytopenia (HP:0001913)1.38975585
83Neoplasm of the small intestine (HP:0100833)1.38111606
84Distal lower limb amyotrophy (HP:0008944)1.37655070
85Thrombocytosis (HP:0001894)1.36815534
86Gastrointestinal inflammation (HP:0004386)1.36331580
87Eosinophilia (HP:0001880)1.36054046
88Polyphagia (HP:0002591)1.35968219
89Elevated erythrocyte sedimentation rate (HP:0003565)1.34625414
90Decreased circulating renin level (HP:0003351)1.32729356
91Vasculitis (HP:0002633)1.32684388
92Basal ganglia calcification (HP:0002135)1.31445378
93Pulmonary embolism (HP:0002204)1.31168657
94Bundle branch block (HP:0011710)1.31151025
95Mucosal telangiectasiae (HP:0100579)1.30811403
96Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.29426756
973-Methylglutaconic aciduria (HP:0003535)1.28604788
98Acute hepatic failure (HP:0006554)1.28278458
99Gastrointestinal infarctions (HP:0005244)1.27534630
100Renal cortical cysts (HP:0000803)1.26576408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.91482740
2MST44.33826426
3BMX3.66911332
4TEC3.32607625
5EIF2AK13.32082236
6MYLK3.09109242
7ACVR1B2.93836147
8BTK2.64646728
9TAOK32.59986744
10PIK3CG2.53423496
11SYK2.34297644
12BMPR22.25283731
13PTK2B2.20047937
14GRK61.84358337
15GRK51.80400431
16STK31.78093579
17ZAP701.68922107
18CSF1R1.66330037
19STK241.43790097
20HCK1.40507202
21FGR1.39467401
22ADRBK21.38933595
23BLK1.35105262
24TNIK1.32062984
25FRK1.18412869
26IRAK11.17693634
27FES1.17411728
28ILK1.14719384
29MAP2K31.14162192
30MATK1.14123989
31LYN1.10513765
32EPHA31.10208910
33PDK11.07179852
34TNK21.05544901
35LMTK21.01018773
36ITK0.97254867
37TXK0.94757704
38IKBKB0.91412780
39MAP3K50.91242050
40NLK0.90395065
41CSK0.88168447
42MAPKAPK30.86770417
43PAK10.83749700
44PDPK10.83068177
45JAK20.81771689
46PLK20.79777592
47RET0.79165185
48ERBB20.79033180
49ADRBK10.75257034
50BMPR1B0.73839452
51PIM20.73509497
52JAK30.73020061
53MARK30.71140576
54JAK10.71096373
55NUAK10.70403754
56MAPK120.69674750
57FER0.68504571
58CAMKK20.67808702
59YES10.66776214
60PIK3CA0.65612841
61STK40.65464432
62PRKACG0.65170746
63MAP2K10.63572931
64OBSCN0.62440699
65SGK20.56927529
66PIM10.56643554
67MAP3K20.55459766
68LCK0.54415373
69DAPK30.54349631
70PRKD10.54268076
71MAPK130.54035009
72DAPK20.52804843
73TRPM70.52771818
74PRKCQ0.51646543
75BRSK20.51048260
76PDGFRB0.48344874
77MAP4K10.47919261
78GRK10.46857700
79PRKG10.46590637
80PKN10.44693334
81FYN0.44096676
82PRKG20.41925030
83SIK30.39937866
84TRIM280.39811805
85RAF10.39459105
86MAP3K10.38867343
87MAPK110.38113939
88SGK30.37773171
89TAOK10.35911930
90PRKCB0.34634054
91PAK30.34503429
92TAOK20.34300518
93EPHB10.33890167
94PRKCA0.33810145
95IRAK40.31911648
96PRKCD0.31595197
97MAP3K30.28043691
98DYRK1B0.22866466
99IGF1R0.21843954
100MAP4K20.21239877

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.96329617
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.63847736
3Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.63654890
4Nitrogen metabolism_Homo sapiens_hsa009102.57170002
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.39146855
6Hematopoietic cell lineage_Homo sapiens_hsa046402.28353214
7Arachidonic acid metabolism_Homo sapiens_hsa005902.22504221
8Fat digestion and absorption_Homo sapiens_hsa049751.99292759
9Renin-angiotensin system_Homo sapiens_hsa046141.87007589
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75479178
11Sulfur metabolism_Homo sapiens_hsa009201.67484997
12Chemokine signaling pathway_Homo sapiens_hsa040621.61231819
13Pancreatic secretion_Homo sapiens_hsa049721.56182463
14Starch and sucrose metabolism_Homo sapiens_hsa005001.54244108
15Linoleic acid metabolism_Homo sapiens_hsa005911.54157299
16Gap junction_Homo sapiens_hsa045401.52727964
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.50190796
18Serotonergic synapse_Homo sapiens_hsa047261.48132630
19Glycerolipid metabolism_Homo sapiens_hsa005611.47125694
20ECM-receptor interaction_Homo sapiens_hsa045121.42809018
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36204001
22B cell receptor signaling pathway_Homo sapiens_hsa046621.35196467
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19505228
24Long-term depression_Homo sapiens_hsa047301.12536392
25Systemic lupus erythematosus_Homo sapiens_hsa053221.12043302
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.07367332
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07266051
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05172315
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04661745
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00561035
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99288739
32Alcoholism_Homo sapiens_hsa050340.98553711
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97710915
34Leukocyte transendothelial migration_Homo sapiens_hsa046700.96465243
35Staphylococcus aureus infection_Homo sapiens_hsa051500.92979787
36T cell receptor signaling pathway_Homo sapiens_hsa046600.88709254
37Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87913845
38Osteoclast differentiation_Homo sapiens_hsa043800.85698368
39Endocytosis_Homo sapiens_hsa041440.85093217
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83948270
41Phospholipase D signaling pathway_Homo sapiens_hsa040720.83604366
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81564372
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.81330083
44Chemical carcinogenesis_Homo sapiens_hsa052040.78606864
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77968380
46Choline metabolism in cancer_Homo sapiens_hsa052310.76135349
47PPAR signaling pathway_Homo sapiens_hsa033200.75515993
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75498266
49Olfactory transduction_Homo sapiens_hsa047400.75208726
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74753743
51Caffeine metabolism_Homo sapiens_hsa002320.74720365
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.73867967
53Bile secretion_Homo sapiens_hsa049760.73120663
54Graft-versus-host disease_Homo sapiens_hsa053320.72949008
55Mineral absorption_Homo sapiens_hsa049780.72342216
56Asthma_Homo sapiens_hsa053100.72269797
57Shigellosis_Homo sapiens_hsa051310.71889034
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71613607
59Malaria_Homo sapiens_hsa051440.71417191
60Collecting duct acid secretion_Homo sapiens_hsa049660.70893493
61Retinol metabolism_Homo sapiens_hsa008300.69811038
62Leishmaniasis_Homo sapiens_hsa051400.68736280
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68034949
64Renin secretion_Homo sapiens_hsa049240.67866008
65Fatty acid elongation_Homo sapiens_hsa000620.66493245
66Allograft rejection_Homo sapiens_hsa053300.65834469
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64779613
68Primary immunodeficiency_Homo sapiens_hsa053400.64338507
69Phagosome_Homo sapiens_hsa041450.63163107
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61846362
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59183492
72Vitamin digestion and absorption_Homo sapiens_hsa049770.58979348
73Pancreatic cancer_Homo sapiens_hsa052120.58893802
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.58842952
75Circadian entrainment_Homo sapiens_hsa047130.58623042
76Arginine and proline metabolism_Homo sapiens_hsa003300.56473934
77Non-small cell lung cancer_Homo sapiens_hsa052230.56336661
78Autoimmune thyroid disease_Homo sapiens_hsa053200.54489511
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52943641
80Rap1 signaling pathway_Homo sapiens_hsa040150.51853168
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.51648643
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51570859
83Glutathione metabolism_Homo sapiens_hsa004800.51247540
84Ether lipid metabolism_Homo sapiens_hsa005650.50105560
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49715001
86ABC transporters_Homo sapiens_hsa020100.49527955
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49375954
88Sphingolipid metabolism_Homo sapiens_hsa006000.48466179
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47662483
90Calcium signaling pathway_Homo sapiens_hsa040200.47352282
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.44999750
92Morphine addiction_Homo sapiens_hsa050320.43143282
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42564866
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42518070
95Tuberculosis_Homo sapiens_hsa051520.41906782
96Focal adhesion_Homo sapiens_hsa045100.41844325
97Viral carcinogenesis_Homo sapiens_hsa052030.41315587
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40226107
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38350748
100Cholinergic synapse_Homo sapiens_hsa047250.37486272

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