ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indolalkylamine metabolic process (GO:0006586)	4.83867470
2	tryptophan catabolic process (GO:0006569)	4.74806571
3	indole-containing compound catabolic process (GO:0042436)	4.74806571
4	indolalkylamine catabolic process (GO:0046218)	4.74806571
5	behavioral response to nicotine (GO:0035095)	4.55597384
6	kynurenine metabolic process (GO:0070189)	4.54966148
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.44886831
8	tryptophan metabolic process (GO:0006568)	4.12504484
9	signal peptide processing (GO:0006465)	4.04884858
10	detection of light stimulus involved in visual perception (GO:0050908)	3.98935255
11	detection of light stimulus involved in sensory perception (GO:0050962)	3.98935255
12	tachykinin receptor signaling pathway (GO:0007217)	3.96749502
13	L-fucose catabolic process (GO:0042355)	3.87585239
14	fucose catabolic process (GO:0019317)	3.87585239
15	L-fucose metabolic process (GO:0042354)	3.87585239
16	behavioral response to ethanol (GO:0048149)	3.69993667
17	photoreceptor cell maintenance (GO:0045494)	3.67994649
18	response to pheromone (GO:0019236)	3.62095327
19	neural tube formation (GO:0001841)	3.58762984
20	auditory receptor cell stereocilium organization (GO:0060088)	3.58211792
21	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.58061401
22	indole-containing compound metabolic process (GO:0042430)	3.54510197
23	cilium or flagellum-dependent cell motility (GO:0001539)	3.47861246
24	cellular ketone body metabolic process (GO:0046950)	3.41810616
25	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.40072875
26	reflex (GO:0060004)	3.34615919
27	centriole replication (GO:0007099)	3.32585934
28	amine catabolic process (GO:0009310)	3.27934458
29	cellular biogenic amine catabolic process (GO:0042402)	3.27934458
30	protein K11-linked deubiquitination (GO:0035871)	3.21440231
31	ketone body metabolic process (GO:1902224)	3.20319199
32	DNA double-strand break processing (GO:0000729)	3.20118900
33	retinal cone cell development (GO:0046549)	3.18422540
34	inner ear receptor stereocilium organization (GO:0060122)	3.12072078
35	regulation of hippo signaling (GO:0035330)	3.11212191
36	nonmotile primary cilium assembly (GO:0035058)	3.08944103
37	benzene-containing compound metabolic process (GO:0042537)	3.04873259
38	gamma-aminobutyric acid transport (GO:0015812)	3.03984200
39	serotonin metabolic process (GO:0042428)	3.02864523
40	axoneme assembly (GO:0035082)	3.00889718
41	dopamine transport (GO:0015872)	2.96007801
42	regulation of sarcomere organization (GO:0060297)	2.95633689
43	regulation of translation, ncRNA-mediated (GO:0045974)	2.90759794
44	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.90759794
45	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.90759794
46	primary amino compound metabolic process (GO:1901160)	2.84444301
47	protein localization to cilium (GO:0061512)	2.83101793
48	aromatic amino acid family catabolic process (GO:0009074)	2.82601671
49	aromatic amino acid family metabolic process (GO:0009072)	2.81832581
50	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.81134717
51	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.77495369
52	reciprocal DNA recombination (GO:0035825)	2.77366902
53	reciprocal meiotic recombination (GO:0007131)	2.77366902
54	NAD biosynthetic process (GO:0009435)	2.74504492
55	oxidative demethylation (GO:0070989)	2.73098685
56	cilium morphogenesis (GO:0060271)	2.72877024
57	protein prenylation (GO:0018342)	2.72699748
58	prenylation (GO:0097354)	2.72699748
59	cilium organization (GO:0044782)	2.72423630
60	establishment of protein localization to Golgi (GO:0072600)	2.72132809
61	double-strand break repair via homologous recombination (GO:0000724)	2.70242659
62	recombinational repair (GO:0000725)	2.70060781
63	rhodopsin mediated signaling pathway (GO:0016056)	2.69713562
64	platelet dense granule organization (GO:0060155)	2.69558538
65	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.67608340
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66460923
67	cilium assembly (GO:0042384)	2.66304597
68	neuronal action potential (GO:0019228)	2.65465235
69	photoreceptor cell development (GO:0042461)	2.65256042
70	mannosylation (GO:0097502)	2.64763334
71	righting reflex (GO:0060013)	2.63945386
72	piRNA metabolic process (GO:0034587)	2.63724151
73	protein polyglutamylation (GO:0018095)	2.62705308
74	sulfation (GO:0051923)	2.62423376
75	regulation of hexokinase activity (GO:1903299)	2.61763178
76	regulation of glucokinase activity (GO:0033131)	2.61763178
77	water-soluble vitamin biosynthetic process (GO:0042364)	2.59496087
78	replication fork processing (GO:0031297)	2.57971309
79	DNA deamination (GO:0045006)	2.57658200
80	adaptation of signaling pathway (GO:0023058)	2.57012619
81	transmission of nerve impulse (GO:0019226)	2.56943892
82	cornea development in camera-type eye (GO:0061303)	2.56326373
83	positive regulation of developmental pigmentation (GO:0048087)	2.56288421
84	monoubiquitinated protein deubiquitination (GO:0035520)	2.55580130
85	protein K63-linked deubiquitination (GO:0070536)	2.55198966
86	negative regulation of mast cell activation (GO:0033004)	2.52838432
87	epithelial cilium movement (GO:0003351)	2.52002103
88	proline transport (GO:0015824)	2.51977953
89	respiratory chain complex IV assembly (GO:0008535)	2.50200202
90	regulation of neurotransmitter uptake (GO:0051580)	2.49998404
91	interkinetic nuclear migration (GO:0022027)	2.45929217
92	cellular response to sterol (GO:0036315)	2.45781196
93	neuronal action potential propagation (GO:0019227)	2.45539559
94	cAMP catabolic process (GO:0006198)	2.45333804
95	cilium movement (GO:0003341)	2.44354668
96	regulation of action potential (GO:0098900)	2.44238666
97	regulation of pigment cell differentiation (GO:0050932)	2.43643650
98	regulation of cilium movement (GO:0003352)	2.43193924
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.43127794
100	thyroid hormone metabolic process (GO:0042403)	2.41694661

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.44632150
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.28682609
3	VDR_22108803_ChIP-Seq_LS180_Human	3.25861859
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.02900725
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.96149090
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.80336582
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67608303
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.67287098
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.53233256
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49976626
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34471374
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29303832
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.24903884
14	P300_19829295_ChIP-Seq_ESCs_Human	2.17114937
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05316456
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.04434363
17	FUS_26573619_Chip-Seq_HEK293_Human	2.03751905
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.03680627
19	EWS_26573619_Chip-Seq_HEK293_Human	1.97804198
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.93501071
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93104635
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87452532
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.85774539
24	STAT3_23295773_ChIP-Seq_U87_Human	1.85165385
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.81565052
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.76629300
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73595888
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72307286
29	TCF4_23295773_ChIP-Seq_U87_Human	1.67395985
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58566714
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.58566714
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.57824347
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57549415
34	AR_25329375_ChIP-Seq_VCAP_Human	1.52015206
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51415085
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49401418
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49140259
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45678332
39	TCF4_22108803_ChIP-Seq_LS180_Human	1.44181653
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42848021
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42848021
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42286308
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40986776
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40123515
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40123515
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38473408
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.38423612
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38095515
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36001500
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35315911
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34763618
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34376618
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34313140
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33376271
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.32414719
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.31741826
57	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.30589901
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.30568428
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30372365
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30276855
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27743440
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25366769
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.24684508
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24386225
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23665842
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23292061
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22664151
68	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22079856
69	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20399874
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.20153066
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19185843
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16090282
73	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.15171533
74	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14239939
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14055900
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12378913
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12144312
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12144312
79	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10216067
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08788150
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.08330427
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08086908
83	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07440019
84	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07198073
85	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06356801
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06317758
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05833591
88	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04380828
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04366851
90	KDM2B_26808549_Chip-Seq_REH_Human	1.03159484
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02386062
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02229147
93	AR_20517297_ChIP-Seq_VCAP_Human	1.02165557
94	TP53_16413492_ChIP-PET_HCT116_Human	1.01839911
95	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.01436940
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01091208
97	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.00546872
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00136775
99	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00066370
100	P300_18555785_Chip-Seq_ESCs_Mouse	1.00012721

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.62356230
2	MP0000569_abnormal_digit_pigmentation	3.29244184
3	MP0005551_abnormal_eye_electrophysiolog	2.85205269
4	MP0000372_irregular_coat_pigmentation	2.65318972
5	MP0001501_abnormal_sleep_pattern	2.52958874
6	MP0004043_abnormal_pH_regulation	2.51451727
7	MP0003646_muscle_fatigue	2.49197816
8	MP0001968_abnormal_touch/_nociception	2.39598648
9	MP0009046_muscle_twitch	2.31970420
10	MP0008877_abnormal_DNA_methylation	2.11644119
11	MP0003136_yellow_coat_color	2.11380351
12	MP0002736_abnormal_nociception_after	2.10744386
13	MP0002102_abnormal_ear_morphology	2.04750670
14	MP0008057_abnormal_DNA_replication	2.04369859
15	MP0005253_abnormal_eye_physiology	2.00692865
16	MP0008872_abnormal_physiological_respon	1.97543416
17	MP0002837_dystrophic_cardiac_calcinosis	1.96920074
18	MP0006276_abnormal_autonomic_nervous	1.81294151
19	MP0005646_abnormal_pituitary_gland	1.78709315
20	MP0006072_abnormal_retinal_apoptosis	1.75441656
21	MP0005645_abnormal_hypothalamus_physiol	1.74981671
22	MP0009745_abnormal_behavioral_response	1.74538176
23	MP0001984_abnormal_olfaction	1.69885085
24	MP0003880_abnormal_central_pattern	1.66085872
25	MP0005174_abnormal_tail_pigmentation	1.65841105
26	MP0002938_white_spotting	1.64267121
27	MP0005670_abnormal_white_adipose	1.62936410
28	MP0000427_abnormal_hair_cycle	1.56057548
29	MP0004142_abnormal_muscle_tone	1.52732434
30	MP0001986_abnormal_taste_sensitivity	1.50094027
31	MP0004147_increased_porphyrin_level	1.49943697
32	MP0001486_abnormal_startle_reflex	1.49090128
33	MP0002638_abnormal_pupillary_reflex	1.47993652
34	MP0006292_abnormal_olfactory_placode	1.47715096
35	MP0002272_abnormal_nervous_system	1.47123356
36	MP0003252_abnormal_bile_duct	1.44487591
37	MP0005083_abnormal_biliary_tract	1.43340141
38	MP0000383_abnormal_hair_follicle	1.43191380
39	MP0001485_abnormal_pinna_reflex	1.42855691
40	MP0010386_abnormal_urinary_bladder	1.42588060
41	MP0003950_abnormal_plasma_membrane	1.38745815
42	MP0005167_abnormal_blood-brain_barrier	1.37578798
43	MP0000631_abnormal_neuroendocrine_gland	1.36782398
44	MP0003787_abnormal_imprinting	1.36634779
45	MP0005085_abnormal_gallbladder_physiolo	1.35153730
46	MP0002735_abnormal_chemical_nociception	1.31062948
47	MP0002572_abnormal_emotion/affect_behav	1.29982752
48	MP0005171_absent_coat_pigmentation	1.29018084
49	MP0002876_abnormal_thyroid_physiology	1.26637252
50	MP0001529_abnormal_vocalization	1.24097372
51	MP0002733_abnormal_thermal_nociception	1.21401093
52	MP0008058_abnormal_DNA_repair	1.20269894
53	MP0001970_abnormal_pain_threshold	1.19903330
54	MP0002557_abnormal_social/conspecific_i	1.19460869
55	MP0004924_abnormal_behavior	1.16719009
56	MP0005386_behavior/neurological_phenoty	1.16719009
57	MP0002067_abnormal_sensory_capabilities	1.15496814
58	MP0003718_maternal_effect	1.14467615
59	MP0002064_seizures	1.13000814
60	MP0004215_abnormal_myocardial_fiber	1.12622669
61	MP0004145_abnormal_muscle_electrophysio	1.12279262
62	MP0002095_abnormal_skin_pigmentation	1.10953817
63	MP0005075_abnormal_melanosome_morpholog	1.10376402
64	MP0008875_abnormal_xenobiotic_pharmacok	1.09487946
65	MP0004885_abnormal_endolymph	1.06805286
66	MP0003635_abnormal_synaptic_transmissio	1.03948744
67	MP0000230_abnormal_systemic_arterial	1.00773744
68	MP0002234_abnormal_pharynx_morphology	1.00409296
69	MP0009697_abnormal_copulation	1.00011864
70	MP0005084_abnormal_gallbladder_morpholo	0.98170240
71	MP0002928_abnormal_bile_duct	0.97881416
72	MP0005379_endocrine/exocrine_gland_phen	0.96956878
73	MP0005410_abnormal_fertilization	0.96917299
74	MP0002229_neurodegeneration	0.94997712
75	MP0005195_abnormal_posterior_eye	0.92043490
76	MP0008961_abnormal_basal_metabolism	0.91196226
77	MP0001963_abnormal_hearing_physiology	0.89875483
78	MP0005365_abnormal_bile_salt	0.89392862
79	MP0003698_abnormal_male_reproductive	0.89276096
80	MP0005377_hearing/vestibular/ear_phenot	0.89071824
81	MP0003878_abnormal_ear_physiology	0.89071824
82	MP0000538_abnormal_urinary_bladder	0.88724898
83	MP0002653_abnormal_ependyma_morphology	0.88611049
84	MP0008775_abnormal_heart_ventricle	0.88012880
85	MP0010329_abnormal_lipoprotein_level	0.87938227
86	MP0004742_abnormal_vestibular_system	0.87670365
87	MP0008995_early_reproductive_senescence	0.87570689
88	MP0002163_abnormal_gland_morphology	0.86191244
89	MP0000015_abnormal_ear_pigmentation	0.84881799
90	MP0001764_abnormal_homeostasis	0.84761999
91	MP0002752_abnormal_somatic_nervous	0.84734020
92	MP0001905_abnormal_dopamine_level	0.83170292
93	MP0003045_fibrosis	0.81895121
94	MP0002063_abnormal_learning/memory/cond	0.80413542
95	MP0002184_abnormal_innervation	0.80413016
96	MP0002168_other_aberrant_phenotype	0.80014930
97	MP0002160_abnormal_reproductive_system	0.79181856
98	MP0005310_abnormal_salivary_gland	0.78337132
99	MP0004085_abnormal_heartbeat	0.78147077
100	MP0000026_abnormal_inner_ear	0.77725582

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.38692269
2	Congenital stationary night blindness (HP:0007642)	3.95866506
3	Pancreatic fibrosis (HP:0100732)	3.94162817
4	Hyperventilation (HP:0002883)	3.86054427
5	True hermaphroditism (HP:0010459)	3.83238281
6	Molar tooth sign on MRI (HP:0002419)	3.72541698
7	Abnormality of midbrain morphology (HP:0002418)	3.72541698
8	Gaze-evoked nystagmus (HP:0000640)	3.59565437
9	Attenuation of retinal blood vessels (HP:0007843)	3.51631207
10	Nephronophthisis (HP:0000090)	3.50914434
11	Abnormality of the renal cortex (HP:0011035)	3.50320413
12	Medial flaring of the eyebrow (HP:0010747)	3.40639035
13	Abnormality of the renal medulla (HP:0100957)	3.29137449
14	Genetic anticipation (HP:0003743)	3.20921657
15	Progressive cerebellar ataxia (HP:0002073)	3.00182552
16	Chronic hepatic failure (HP:0100626)	2.93638768
17	Type II lissencephaly (HP:0007260)	2.90868781
18	Abolished electroretinogram (ERG) (HP:0000550)	2.88445535
19	Cystic liver disease (HP:0006706)	2.85168188
20	Gait imbalance (HP:0002141)	2.81874870
21	Protruding tongue (HP:0010808)	2.78395868
22	Congenital primary aphakia (HP:0007707)	2.76694654
23	Absent speech (HP:0001344)	2.74866739
24	Fair hair (HP:0002286)	2.68333677
25	Bony spicule pigmentary retinopathy (HP:0007737)	2.61045634
26	Febrile seizures (HP:0002373)	2.60976325
27	Polydipsia (HP:0001959)	2.54624258
28	Abnormal drinking behavior (HP:0030082)	2.54624258
29	Nephrogenic diabetes insipidus (HP:0009806)	2.54362032
30	Tubular atrophy (HP:0000092)	2.53549522
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.51676148
32	Cerebellar dysplasia (HP:0007033)	2.48716635
33	Congenital sensorineural hearing impairment (HP:0008527)	2.46735250
34	Renal cortical cysts (HP:0000803)	2.43773001
35	Decreased central vision (HP:0007663)	2.43760967
36	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.43214710
37	Clumsiness (HP:0002312)	2.41364222
38	Keratoconus (HP:0000563)	2.41250877
39	Increased corneal curvature (HP:0100692)	2.41250877
40	Inability to walk (HP:0002540)	2.40314413
41	Genital tract atresia (HP:0001827)	2.38798909
42	Congenital hepatic fibrosis (HP:0002612)	2.33585081
43	Vaginal atresia (HP:0000148)	2.30961032
44	Sclerocornea (HP:0000647)	2.30958352
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.30054431
46	Ketoacidosis (HP:0001993)	2.28391298
47	Large for gestational age (HP:0001520)	2.27489716
48	Broad-based gait (HP:0002136)	2.26599786
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.26591280
50	Progressive inability to walk (HP:0002505)	2.24926183
51	Hypothermia (HP:0002045)	2.24116045
52	Abnormality of macular pigmentation (HP:0008002)	2.20983334
53	Lissencephaly (HP:0001339)	2.18725612
54	Generalized hypopigmentation of hair (HP:0011358)	2.18407183
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16850611
56	Abnormality of alanine metabolism (HP:0010916)	2.16850611
57	Hyperalaninemia (HP:0003348)	2.16850611
58	Decreased circulating renin level (HP:0003351)	2.16814015
59	Furrowed tongue (HP:0000221)	2.16053142
60	Postaxial foot polydactyly (HP:0001830)	2.14669594
61	Polyuria (HP:0000103)	2.11521784
62	Widely spaced teeth (HP:0000687)	2.09598942
63	Stomach cancer (HP:0012126)	2.08199240
64	Central scotoma (HP:0000603)	2.06782250
65	Abnormal biliary tract physiology (HP:0012439)	2.00013102
66	Bile duct proliferation (HP:0001408)	2.00013102
67	Intestinal atresia (HP:0011100)	1.99703509
68	Anencephaly (HP:0002323)	1.99269145
69	Poor coordination (HP:0002370)	1.97556911
70	Ketosis (HP:0001946)	1.94489186
71	Astigmatism (HP:0000483)	1.92709552
72	Pendular nystagmus (HP:0012043)	1.92599506
73	Focal seizures (HP:0007359)	1.90934562
74	Tubulointerstitial nephritis (HP:0001970)	1.90170405
75	Small hand (HP:0200055)	1.90072465
76	Abnormality of the pons (HP:0007361)	1.89437801
77	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.89039112
78	Constricted visual fields (HP:0001133)	1.88397060
79	Dialeptic seizures (HP:0011146)	1.86221800
80	Hemiparesis (HP:0001269)	1.84811995
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84277372
82	Retinitis pigmentosa (HP:0000510)	1.84238835
83	Retinal dysplasia (HP:0007973)	1.83377690
84	Short foot (HP:0001773)	1.83162770
85	Hypoplasia of the pons (HP:0012110)	1.83100986
86	Tubulointerstitial abnormality (HP:0001969)	1.81659050
87	Postaxial hand polydactyly (HP:0001162)	1.81363274
88	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.80391105
89	Hypoplasia of the fovea (HP:0007750)	1.80391105
90	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.79559119
91	Methylmalonic acidemia (HP:0002912)	1.77288983
92	Chorioretinal atrophy (HP:0000533)	1.76777592
93	Methylmalonic aciduria (HP:0012120)	1.76219172
94	Male pseudohermaphroditism (HP:0000037)	1.76196082
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75860195
96	Absent/shortened dynein arms (HP:0200106)	1.75860195
97	Colon cancer (HP:0003003)	1.74817589
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68437408
99	Neoplasm of the adrenal cortex (HP:0100641)	1.67325795
100	Preaxial hand polydactyly (HP:0001177)	1.66720211

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.14436812
2	BMPR1B	3.06855977
3	MAP4K2	2.94980731
4	ACVR1B	2.77670305
5	ADRBK2	2.66721881
6	NUAK1	2.65919151
7	INSRR	2.40400845
8	WNK3	2.25567722
9	ZAK	2.10870452
10	GRK1	2.08019246
11	MAPK13	1.86228930
12	CASK	1.79463764
13	STK38L	1.72019393
14	TAOK3	1.63682300
15	MAP3K4	1.58617063
16	MKNK2	1.48126758
17	CCNB1	1.48112802
18	WNK4	1.47055311
19	PINK1	1.42705680
20	TNIK	1.40703414
21	CAMKK2	1.39948235
22	TRIM28	1.35823200
23	STK39	1.31033687
24	OXSR1	1.26891678
25	LATS1	1.23626023
26	PIK3CG	1.20108833
27	MUSK	1.14498808
28	NTRK3	1.13421772
29	BRSK2	1.10079973
30	NEK2	1.09721351
31	ADRBK1	1.06761396
32	AKT3	1.05705645
33	STK3	1.02923843
34	PTK2B	1.02034397
35	PAK3	1.01681327
36	TIE1	0.99812386
37	TAF1	0.99062197
38	PRKCE	0.98796839
39	DAPK2	0.97889737
40	TEC	0.94097991
41	TXK	0.91320987
42	VRK1	0.89225325
43	BCR	0.87251332
44	PLK2	0.86386996
45	VRK2	0.85366110
46	CSNK1G1	0.85324546
47	CSNK1G2	0.85041119
48	CSNK1A1L	0.84130008
49	MAPKAPK5	0.83171841
50	TNK2	0.80895633
51	MARK1	0.80857267
52	CSNK1G3	0.80819755
53	TGFBR1	0.80650856
54	PRKCG	0.80413849
55	CAMK1D	0.79812901
56	FER	0.74472558
57	MKNK1	0.74099646
58	MAP2K7	0.71003332
59	ERBB3	0.70692508
60	EPHA4	0.68300652
61	CAMK1G	0.63395989
62	PRKAA2	0.63292130
63	MST4	0.63096131
64	EIF2AK3	0.61150309
65	FGFR2	0.57829460
66	PKN1	0.57603555
67	CAMK1	0.55398662
68	PNCK	0.54710340
69	PIK3CA	0.54244499
70	IRAK1	0.54219530
71	GRK5	0.54189774
72	NLK	0.53475371
73	PLK3	0.52510342
74	PLK4	0.51228014
75	FLT3	0.50510551
76	TLK1	0.48788576
77	CAMK2A	0.48327908
78	KIT	0.48121328
79	MAP3K7	0.46940321
80	DYRK2	0.46884567
81	WEE1	0.45620259
82	CHUK	0.45247273
83	OBSCN	0.44853447
84	IKBKB	0.42747357
85	PRKAA1	0.39220691
86	PRKACA	0.38098936
87	CSNK1D	0.37850761
88	PRKCQ	0.36295705
89	MAPKAPK3	0.35358841
90	TRPM7	0.35206845
91	CSNK1A1	0.33884546
92	PHKG2	0.32804601
93	PHKG1	0.32804601
94	CHEK2	0.30964398
95	PRKCA	0.29940701
96	CAMK4	0.29451819
97	ATM	0.28297988
98	MELK	0.28245554
99	MARK3	0.28089245
100	PDK2	0.26712329

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.16924413
2	Butanoate metabolism_Homo sapiens_hsa00650	2.91580864
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.64796283
4	Nicotine addiction_Homo sapiens_hsa05033	2.55965834
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39817311
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.38407431
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.30079618
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26561735
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.25871410
10	Homologous recombination_Homo sapiens_hsa03440	2.25264250
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15011426
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.12854519
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.12350306
14	ABC transporters_Homo sapiens_hsa02010	1.93563511
15	Olfactory transduction_Homo sapiens_hsa04740	1.81030938
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.78742070
17	Taste transduction_Homo sapiens_hsa04742	1.75371458
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.69520371
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.67885068
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.67542561
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.65894292
22	Propanoate metabolism_Homo sapiens_hsa00640	1.63444185
23	Morphine addiction_Homo sapiens_hsa05032	1.63441432
24	Basal transcription factors_Homo sapiens_hsa03022	1.62477511
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59395975
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55970377
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54355299
28	Caffeine metabolism_Homo sapiens_hsa00232	1.51769086
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49977131
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44891863
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.41115117
32	Circadian entrainment_Homo sapiens_hsa04713	1.30617129
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.28485685
34	Glutamatergic synapse_Homo sapiens_hsa04724	1.26459768
35	Retinol metabolism_Homo sapiens_hsa00830	1.24952052
36	GABAergic synapse_Homo sapiens_hsa04727	1.24040903
37	Serotonergic synapse_Homo sapiens_hsa04726	1.22410957
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21672680
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19739010
40	Glycerolipid metabolism_Homo sapiens_hsa00561	1.18260582
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13260040
42	Protein export_Homo sapiens_hsa03060	1.13089030
43	Salivary secretion_Homo sapiens_hsa04970	1.13009619
44	Insulin secretion_Homo sapiens_hsa04911	1.11098641
45	beta-Alanine metabolism_Homo sapiens_hsa00410	1.09830931
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.02467158
47	Calcium signaling pathway_Homo sapiens_hsa04020	1.02185115
48	One carbon pool by folate_Homo sapiens_hsa00670	1.00063352
49	Peroxisome_Homo sapiens_hsa04146	0.98319766
50	Regulation of autophagy_Homo sapiens_hsa04140	0.96023010
51	Histidine metabolism_Homo sapiens_hsa00340	0.95520445
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93751545
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86553584
54	Lysine degradation_Homo sapiens_hsa00310	0.82005501
55	RNA polymerase_Homo sapiens_hsa03020	0.81057859
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77241597
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76169235
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.75437382
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74401259
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.73941818
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70513504
62	RNA degradation_Homo sapiens_hsa03018	0.67928472
63	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67237330
64	Circadian rhythm_Homo sapiens_hsa04710	0.65095476
65	Long-term depression_Homo sapiens_hsa04730	0.64892931
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64154961
67	Fatty acid degradation_Homo sapiens_hsa00071	0.61971106
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61825689
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60480985
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58156632
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57185704
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56203857
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.55079512
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53503936
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.53357010
76	Metabolic pathways_Homo sapiens_hsa01100	0.52768463
77	Renin secretion_Homo sapiens_hsa04924	0.51436696
78	Purine metabolism_Homo sapiens_hsa00230	0.51040282
79	Cholinergic synapse_Homo sapiens_hsa04725	0.49880347
80	Asthma_Homo sapiens_hsa05310	0.48524170
81	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45249987
82	Pancreatic secretion_Homo sapiens_hsa04972	0.43022125
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.42157971
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.41450611
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40707965
86	Sulfur metabolism_Homo sapiens_hsa00920	0.39057913
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38263856
88	Gastric acid secretion_Homo sapiens_hsa04971	0.37053636
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36666697
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.35570001
91	Cocaine addiction_Homo sapiens_hsa05030	0.34076600
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.32470302
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.31577843
94	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28231432
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.27903555
96	Mineral absorption_Homo sapiens_hsa04978	0.27678825
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.26841365
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.26790812
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.26685249
100	Amphetamine addiction_Homo sapiens_hsa05031	0.26152021

C2ORF91

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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