C3AR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.93454937
2positive regulation by organism of defense response of other organism involved in symbiotic interact7.93454937
3modulation by symbiont of host immune response (GO:0052553)7.93454937
4positive regulation by symbiont of host defense response (GO:0052509)7.93454937
5modulation by symbiont of host defense response (GO:0052031)7.93454937
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.93454937
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.94490657
8regulation of interferon-beta biosynthetic process (GO:0045357)6.87743955
9microglial cell activation (GO:0001774)6.26574429
10macrophage activation involved in immune response (GO:0002281)5.93028338
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.48652481
12neutrophil activation involved in immune response (GO:0002283)5.47806390
13positive regulation of interferon-alpha production (GO:0032727)5.46499718
14response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.20473793
15response to host immune response (GO:0052572)5.20473793
16regulation of interferon-alpha production (GO:0032647)5.20304785
17macrophage activation (GO:0042116)4.96351855
18response to peptidoglycan (GO:0032494)4.79231008
19positive regulation of gamma-delta T cell activation (GO:0046645)4.74439821
20response to host (GO:0075136)4.70685831
21response to host defenses (GO:0052200)4.70685831
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.70685831
23immunoglobulin mediated immune response (GO:0016064)4.61837695
24positive regulation of antigen processing and presentation (GO:0002579)4.51391517
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.42082326
26respiratory burst (GO:0045730)4.34298604
27regulation of B cell receptor signaling pathway (GO:0050855)4.33353408
28myeloid cell activation involved in immune response (GO:0002275)4.23936940
29pinocytosis (GO:0006907)4.22532323
30detection of other organism (GO:0098543)4.07703232
31regulation of antigen processing and presentation (GO:0002577)3.85691752
32I-kappaB phosphorylation (GO:0007252)3.84498011
33detection of external biotic stimulus (GO:0098581)3.83458649
34regulation of interleukin-8 biosynthetic process (GO:0045414)3.83349502
35positive regulation of interferon-beta production (GO:0032728)3.78742528
36production of molecular mediator involved in inflammatory response (GO:0002532)3.77394521
37cellular response to thyroid hormone stimulus (GO:0097067)3.76566457
38positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.70100321
39positive regulation of cellular amide metabolic process (GO:0034250)3.65785104
40detection of bacterium (GO:0016045)3.64658121
41positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.63145390
42cellular extravasation (GO:0045123)3.61980574
43T-helper 1 type immune response (GO:0042088)3.61768324
44negative regulation of interleukin-17 production (GO:0032700)3.60708652
45regulation of T cell tolerance induction (GO:0002664)3.52355930
46detection of molecule of bacterial origin (GO:0032490)3.51907711
47neutrophil activation (GO:0042119)3.51570985
48positive regulation of monocyte chemotaxis (GO:0090026)3.51532559
49granulocyte activation (GO:0036230)3.51122173
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.49098415
51positive regulation of mast cell activation (GO:0033005)3.47836685
52detection of biotic stimulus (GO:0009595)3.46896889
53lymphocyte chemotaxis (GO:0048247)3.45876508
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.45563641
55regulation of dendritic cell antigen processing and presentation (GO:0002604)3.45412771
56positive regulation of macrophage cytokine production (GO:0060907)3.42886136
57regulation of tolerance induction (GO:0002643)3.40699110
58positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.40002591
59negative regulation of mast cell activation (GO:0033004)3.37718071
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35839426
61regulation of mast cell degranulation (GO:0043304)3.32835351
62regulation of gamma-delta T cell activation (GO:0046643)3.32588431
63monocyte chemotaxis (GO:0002548)3.31283912
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.31119337
65amino sugar catabolic process (GO:0046348)3.31050626
66positive regulation of type 2 immune response (GO:0002830)3.26250623
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25642970
68B cell mediated immunity (GO:0019724)3.22095779
69regulation of mast cell activation (GO:0033003)3.21817117
70myeloid leukocyte activation (GO:0002274)3.21746868
71G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.21718833
72positive regulation of lymphocyte migration (GO:2000403)3.19535250
73regulation of cholesterol storage (GO:0010885)3.19071940
74* regulation of mononuclear cell migration (GO:0071675)3.18501633
75regulation of mast cell activation involved in immune response (GO:0033006)3.18297396
76phagocytosis, engulfment (GO:0006911)3.16140487
77eosinophil migration (GO:0072677)3.14288635
78germinal center formation (GO:0002467)3.13696562
79positive regulation of T cell migration (GO:2000406)3.13163022
80regulation of hypersensitivity (GO:0002883)3.09438974
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.09362058
82negative regulation of granulocyte differentiation (GO:0030853)3.08349007
83positive regulation of leukocyte degranulation (GO:0043302)3.04778504
84regulation of T-helper 2 cell differentiation (GO:0045628)3.04306871
85neutrophil mediated immunity (GO:0002446)3.03024038
86positive regulation of mast cell degranulation (GO:0043306)3.02883114
87positive regulation of mast cell activation involved in immune response (GO:0033008)3.02883114
88regulation of leukocyte degranulation (GO:0043300)3.01470713
89glycolipid catabolic process (GO:0019377)2.97786450
90response to muramyl dipeptide (GO:0032495)2.97574330
91regulation of monocyte chemotaxis (GO:0090025)2.96807508
92negative regulation of cytokine production involved in immune response (GO:0002719)2.95780971
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95131789
94mast cell activation (GO:0045576)2.94813295
95antigen processing and presentation of endogenous antigen (GO:0019883)2.94531970
96myeloid dendritic cell differentiation (GO:0043011)2.94499939
97response to thyroid hormone (GO:0097066)2.93105386
98defense response to protozoan (GO:0042832)2.92990860
99positive regulation of toll-like receptor signaling pathway (GO:0034123)2.92369369
100response to interferon-alpha (GO:0035455)2.92068245
101positive regulation of B cell differentiation (GO:0045579)2.91629563
102leukocyte aggregation (GO:0070486)2.91487101
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90236524
104N-acetylneuraminate metabolic process (GO:0006054)2.89774890
105positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.88550953
106response to lipoprotein particle (GO:0055094)2.88358900
107natural killer cell mediated immunity (GO:0002228)2.88259617
108natural killer cell mediated cytotoxicity (GO:0042267)2.88259617
109oligosaccharide catabolic process (GO:0009313)2.88242339
110hyaluronan catabolic process (GO:0030214)2.87585720
111eosinophil chemotaxis (GO:0048245)2.87537512
112granulocyte chemotaxis (GO:0071621)2.87104749
113NIK/NF-kappaB signaling (GO:0038061)2.87006619
114adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.85590199
115negative regulation of interleukin-12 production (GO:0032695)2.85517305
116negative regulation of erythrocyte differentiation (GO:0045647)2.84366367
117interferon-gamma-mediated signaling pathway (GO:0060333)2.84306643
118cellular response to interferon-gamma (GO:0071346)2.83892858
119type I interferon signaling pathway (GO:0060337)2.83330339
120cellular response to type I interferon (GO:0071357)2.83330339
121regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81849911
122neutrophil migration (GO:1990266)2.81769448
123regulation of vitamin D biosynthetic process (GO:0060556)2.81469858
124positive regulation of chemokine production (GO:0032722)2.81096900
125B cell receptor signaling pathway (GO:0050853)2.80875182
126response to type I interferon (GO:0034340)2.79854361
127negative regulation of cell killing (GO:0031342)2.79158794
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79158794
129regulation of interferon-beta production (GO:0032648)2.78461621
130neutrophil chemotaxis (GO:0030593)2.76406543
131cell adhesion mediated by integrin (GO:0033627)2.75591359
132lymphocyte mediated immunity (GO:0002449)2.75307362
133regulation of lymphocyte migration (GO:2000401)2.75180395
134leukocyte mediated cytotoxicity (GO:0001909)2.73614199
135glycosphingolipid catabolic process (GO:0046479)2.72797182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.47327334
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.04863684
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.18925672
4* IRF8_27001747_Chip-Seq_BMDM_Mouse5.42263926
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.97439154
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.20124543
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.19947279
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53193342
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28303442
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21940402
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04734988
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.83906850
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82402108
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71254459
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56468896
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46006179
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32990310
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.30714376
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.30294764
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.27148740
21SPI1_23547873_ChIP-Seq_NB4_Human2.22745210
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15005262
23SPI1_23127762_ChIP-Seq_K562_Human2.07450106
24PU_27001747_Chip-Seq_BMDM_Mouse2.07050384
25VDR_24787735_ChIP-Seq_THP-1_Human2.06657980
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06071934
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97840374
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.95362084
29SCL_19346495_ChIP-Seq_HPC-7_Human1.85899178
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79948932
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.78160251
32RUNX_20019798_ChIP-Seq_JUKART_Human1.77439735
33VDR_24763502_ChIP-Seq_THP-1_Human1.75891326
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65982212
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64924963
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61892946
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55717589
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52311227
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47640969
40MYB_26560356_Chip-Seq_TH2_Human1.44566229
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43449193
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.42224082
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41918944
44* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40397400
45* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39034027
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37154292
47VDR_21846776_ChIP-Seq_THP-1_Human1.34379087
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34347163
49MAF_26560356_Chip-Seq_TH1_Human1.30411175
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.26063465
51LXR_22292898_ChIP-Seq_THP-1_Human1.20812926
52GATA1_22025678_ChIP-Seq_K562_Human1.20611127
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18557586
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13938824
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13782262
56GATA3_26560356_Chip-Seq_TH2_Human1.13673301
57* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13522596
58EGR1_19032775_ChIP-ChIP_M12_Human1.13501573
59KDM2B_26808549_Chip-Seq_DND41_Human1.11823344
60MAF_26560356_Chip-Seq_TH2_Human1.10159225
61MYB_26560356_Chip-Seq_TH1_Human1.09756493
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08465593
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06278671
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03431822
65* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02549738
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02413295
67MYC_22102868_ChIP-Seq_BL_Human1.02284633
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99863663
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98508894
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96910977
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96657891
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96544250
73ESR1_21235772_ChIP-Seq_MCF-7_Human0.95153340
74STAT1_20625510_ChIP-Seq_HELA_Human0.94311717
75TFEB_21752829_ChIP-Seq_HELA_Human0.93838210
76CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93681019
77GATA3_27048872_Chip-Seq_THYMUS_Human0.92549425
78BCL6_27268052_Chip-Seq_Bcells_Human0.90367047
79GATA1_19941826_ChIP-Seq_K562_Human0.89526271
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88685300
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87386136
82* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87115654
83TCF7_22412390_ChIP-Seq_EML_Mouse0.86980944
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86672041
85BCOR_27268052_Chip-Seq_Bcells_Human0.85926873
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84421249
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83362990
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82810055
89SPI1_20517297_ChIP-Seq_HL60_Human0.82383320
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81859799
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81810850
92UTX_26944678_Chip-Seq_JUKART_Human0.81718816
93IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81453551
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81177185
95GATA2_19941826_ChIP-Seq_K562_Human0.79759645
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79084001
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78733636
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78733636
99* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78141421
100CJUN_26792858_Chip-Seq_BT549_Human0.77626060
101SOX2_20726797_ChIP-Seq_SW620_Human0.76871068
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76368758
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.73261335
104RXR_22158963_ChIP-Seq_LIVER_Mouse0.71851417
105PPARA_22158963_ChIP-Seq_LIVER_Mouse0.71329524
106* GATA1_19941827_ChIP-Seq_MEL_Mouse0.70740958
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.70586798
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70110616
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69612691
110NCOR1_26117541_ChIP-Seq_K562_Human0.69392679
111GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68725389
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68159549
113LXR_22158963_ChIP-Seq_LIVER_Mouse0.67822733
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67482850
115SMRT_27268052_Chip-Seq_Bcells_Human0.67110757
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.64245400
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63117186
118* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62998991
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62523672
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.61746195
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.60848824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.05067994
2MP0001835_abnormal_antigen_presentation4.28020368
3MP0003436_decreased_susceptibility_to3.81353064
4MP0006082_CNS_inflammation3.70595456
5MP0003303_peritoneal_inflammation3.64199983
6MP0003172_abnormal_lysosome_physiology3.49599572
7* MP0002419_abnormal_innate_immunity3.18860127
8* MP0002148_abnormal_hypersensitivity_rea2.98611703
9* MP0005000_abnormal_immune_tolerance2.82800110
10MP0009840_abnormal_foam_cell2.77922359
11MP0009785_altered_susceptibility_to2.62888723
12MP0003191_abnormal_cellular_cholesterol2.61042411
13MP0003690_abnormal_glial_cell2.53811878
14MP0005025_abnormal_response_to2.49219445
15* MP0002452_abnormal_antigen_presenting2.45759845
16MP0005464_abnormal_platelet_physiology2.32874827
17MP0000604_amyloidosis2.31647481
18MP0001533_abnormal_skeleton_physiology2.29061939
19* MP0001800_abnormal_humoral_immune2.21864382
20* MP0002723_abnormal_immune_serum2.20489090
21* MP0001790_abnormal_immune_system2.18760237
22* MP0005387_immune_system_phenotype2.18760237
23MP0005671_abnormal_response_to2.09399360
24MP0003724_increased_susceptibility_to2.08255223
25MP0000569_abnormal_digit_pigmentation2.01586878
26MP0004510_myositis1.98870109
27* MP0001819_abnormal_immune_cell1.96623427
28* MP0002420_abnormal_adaptive_immunity1.95248159
29MP0003075_altered_response_to1.94163625
30MP0003300_gastrointestinal_ulcer1.92403662
31MP0000343_altered_response_to1.91247052
32MP0005310_abnormal_salivary_gland1.84654032
33MP0005257_abnormal_intraocular_pressure1.82636766
34MP0000685_abnormal_immune_system1.82302446
35MP0002405_respiratory_system_inflammati1.79497098
36MP0003448_altered_tumor_morphology1.78975430
37* MP0001845_abnormal_inflammatory_respons1.65790244
38MP0010307_abnormal_tumor_latency1.62161351
39MP0002998_abnormal_bone_remodeling1.61686405
40MP0004947_skin_inflammation1.57449071
41MP0003828_pulmonary_edema1.53457051
42* MP0008469_abnormal_protein_level1.51401172
43MP0001853_heart_inflammation1.51117472
44MP0005166_decreased_susceptibility_to1.46023341
45MP0009764_decreased_sensitivity_to1.42991372
46MP0003183_abnormal_peptide_metabolism1.38705994
47MP0000465_gastrointestinal_hemorrhage1.36241224
48MP0005451_abnormal_body_composition1.34788082
49MP0008438_abnormal_cutaneous_collagen1.34563062
50MP0002139_abnormal_hepatobiliary_system1.33343445
51* MP0000716_abnormal_immune_system1.33186137
52MP0008260_abnormal_autophagy1.33179251
53MP0005167_abnormal_blood-brain_barrier1.32913672
54MP0003806_abnormal_nucleotide_metabolis1.29688787
55MP0000689_abnormal_spleen_morphology1.29526051
56MP0010155_abnormal_intestine_physiology1.26105070
57MP0009278_abnormal_bone_marrow1.20278931
58MP0001851_eye_inflammation1.18156437
59MP0000858_altered_metastatic_potential1.17794228
60MP0005174_abnormal_tail_pigmentation1.16901137
61* MP0002398_abnormal_bone_marrow1.15787173
62MP0008004_abnormal_stomach_pH1.14695421
63MP0009333_abnormal_splenocyte_physiolog1.13752072
64MP0005390_skeleton_phenotype1.08680678
65* MP0002429_abnormal_blood_cell1.06333273
66MP0000015_abnormal_ear_pigmentation1.04990494
67MP0002933_joint_inflammation1.04448770
68MP0005164_abnormal_response_to1.04073460
69MP0002722_abnormal_immune_system1.03826527
70MP0003566_abnormal_cell_adhesion1.02174192
71MP0003329_amyloid_beta_deposits1.02141322
72MP0002396_abnormal_hematopoietic_system0.98945545
73MP0002090_abnormal_vision0.98276945
74MP0003763_abnormal_thymus_physiology0.96201422
75MP0006054_spinal_hemorrhage0.96076522
76MP0002166_altered_tumor_susceptibility0.94455418
77MP0005076_abnormal_cell_differentiation0.92847149
78MP0004883_abnormal_blood_vessel0.91490435
79MP0003453_abnormal_keratinocyte_physiol0.91447114
80MP0000249_abnormal_blood_vessel0.90101677
81MP0002254_reproductive_system_inflammat0.89877372
82MP0005197_abnormal_uvea_morphology0.88486922
83MP0004782_abnormal_surfactant_physiolog0.86844544
84MP0003795_abnormal_bone_structure0.84946243
85MP0005397_hematopoietic_system_phenotyp0.84573593
86MP0001545_abnormal_hematopoietic_system0.84573593
87MP0000371_diluted_coat_color0.78459334
88MP0001663_abnormal_digestive_system0.77534759
89MP0000767_abnormal_smooth_muscle0.77282275
90MP0009765_abnormal_xenobiotic_induced0.76907153
91MP0002877_abnormal_melanocyte_morpholog0.75980341
92MP0003866_abnormal_defecation0.73907385
93* MP0009763_increased_sensitivity_to0.72884916
94MP0002006_tumorigenesis0.71879255
95MP0001915_intracranial_hemorrhage0.71142652
96MP0005165_increased_susceptibility_to0.69165284
97MP0003279_aneurysm0.69063945
98MP0003656_abnormal_erythrocyte_physiolo0.68778394
99MP0003045_fibrosis0.68358344
100* MP0000920_abnormal_myelination0.67518618
101MP0005365_abnormal_bile_salt0.65861938
102MP0000490_abnormal_crypts_of0.65401476
103MP0005083_abnormal_biliary_tract0.65257533
104MP0003634_abnormal_glial_cell0.65148769
105MP0002138_abnormal_hepatobiliary_system0.64826928
106MP0004130_abnormal_muscle_cell0.63410333
107MP0008874_decreased_physiological_sensi0.62519409
108MP0002332_abnormal_exercise_endurance0.61347151
109MP0001958_emphysema0.60352456
110MP0002136_abnormal_kidney_physiology0.60085827
111MP0001873_stomach_inflammation0.59921017
112MP0002132_abnormal_respiratory_system0.59060372
113MP0001542_abnormal_bone_strength0.58921321
114MP0005171_absent_coat_pigmentation0.57029256
115MP0004808_abnormal_hematopoietic_stem0.56849650
116MP0005584_abnormal_enzyme/coenzyme_acti0.56672025
117MP0005319_abnormal_enzyme/_coenzyme0.56026801
118MP0003195_calcinosis0.55349027
119MP0003091_abnormal_cell_migration0.55025870
120MP0000703_abnormal_thymus_morphology0.53739275
121MP0003705_abnormal_hypodermis_morpholog0.52699387
122MP0003633_abnormal_nervous_system0.48871499
123MP0009115_abnormal_fat_cell0.48232835
124* MP0000609_abnormal_liver_physiology0.47780891

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.90892027
2Increased cerebral lipofuscin (HP:0011813)6.63343249
3Recurrent abscess formation (HP:0002722)6.60569742
4Vacuolated lymphocytes (HP:0001922)6.33656210
5Increased neuronal autofluorescent lipopigment (HP:0002074)6.02563798
6Glomerulonephritis (HP:0000099)5.94396829
7Recurrent bacterial skin infections (HP:0005406)5.71932826
8Eczematoid dermatitis (HP:0000976)5.44222437
9Dysostosis multiplex (HP:0000943)4.87985880
10Abnormality of glycolipid metabolism (HP:0010969)4.75338809
11Abnormality of liposaccharide metabolism (HP:0010968)4.75338809
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.75338809
13Recurrent gram-negative bacterial infections (HP:0005420)4.74304372
14Abnormality of macrophages (HP:0004311)4.70502074
15Disinhibition (HP:0000734)4.68708229
16Complement deficiency (HP:0004431)4.44108028
17Axonal loss (HP:0003447)4.33424138
18Abnormality of complement system (HP:0005339)4.04867612
19Mucopolysacchariduria (HP:0008155)3.88611576
20Urinary glycosaminoglycan excretion (HP:0003541)3.88611576
21Thick nail (HP:0001805)3.83405689
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.78815416
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.73699625
24Abnormality of polysaccharide metabolism (HP:0011012)3.73699625
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.73699625
26Agnosia (HP:0010524)3.73648743
27Prostate neoplasm (HP:0100787)3.67453131
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.44949250
29Nephritis (HP:0000123)3.32320882
30Gingivitis (HP:0000230)3.29686681
31Myocardial infarction (HP:0001658)3.28645285
32Recurrent skin infections (HP:0001581)3.24638787
33Chronic obstructive pulmonary disease (HP:0006510)3.24131432
34Obstructive lung disease (HP:0006536)3.24131432
35Mediastinal lymphadenopathy (HP:0100721)3.23030313
36Myositis (HP:0100614)3.21111694
37Orchitis (HP:0100796)3.13676728
38Upper motor neuron abnormality (HP:0002127)3.13174137
39Pustule (HP:0200039)3.12647645
40Amyloidosis (HP:0011034)2.96743782
41Basal ganglia calcification (HP:0002135)2.89701275
42Loss of speech (HP:0002371)2.84582253
43Optic neuritis (HP:0100653)2.84045870
44Retrobulbar optic neuritis (HP:0100654)2.84045870
45Hemoptysis (HP:0002105)2.83330046
46Hematochezia (HP:0002573)2.80356359
47Autoimmune thrombocytopenia (HP:0001973)2.79936506
48Pathologic fracture (HP:0002756)2.77449261
49Purpura (HP:0000979)2.72233339
50Keratoconjunctivitis sicca (HP:0001097)2.72115273
51Spontaneous hematomas (HP:0007420)2.70945497
52J-shaped sella turcica (HP:0002680)2.69126714
53Hepatosplenomegaly (HP:0001433)2.68587207
54T lymphocytopenia (HP:0005403)2.66529794
55Increased serum ferritin (HP:0003281)2.62598003
56Recurrent fungal infections (HP:0002841)2.57825347
57Inappropriate behavior (HP:0000719)2.53890493
58Abnormality of T cell number (HP:0011839)2.52848887
59Progressive visual loss (HP:0000529)2.52039529
60Gastrointestinal infarctions (HP:0005244)2.47545362
61Keratoconjunctivitis (HP:0001096)2.47488201
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.45817003
63Stomatitis (HP:0010280)2.42214031
64Cellulitis (HP:0100658)2.39700366
65Osteolytic defects of the hand bones (HP:0009699)2.38166883
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.38166883
67Premature loss of primary teeth (HP:0006323)2.37634045
68Retinal atrophy (HP:0001105)2.36243168
69Elevated erythrocyte sedimentation rate (HP:0003565)2.35834005
70Mutism (HP:0002300)2.35763392
71Peripheral demyelination (HP:0011096)2.35065009
72Encephalitis (HP:0002383)2.34903532
73Periodontitis (HP:0000704)2.31659077
74Apathy (HP:0000741)2.28300970
75Abnormality of the lumbar spine (HP:0100712)2.28272972
76Osteomyelitis (HP:0002754)2.27590050
77Diminished motivation (HP:0000745)2.27093404
78Recurrent pneumonia (HP:0006532)2.26218457
79Conjunctival telangiectasia (HP:0000524)2.25487974
80Recurrent viral infections (HP:0004429)2.25436327
81Bone pain (HP:0002653)2.23633907
82Urticaria (HP:0001025)2.22569842
83Abnormality of iron homeostasis (HP:0011031)2.22060828
84Arterial tortuosity (HP:0005116)2.21612840
85Increased IgM level (HP:0003496)2.21521300
86Tetraparesis (HP:0002273)2.19850364
87Polyneuropathy (HP:0001271)2.18434776
88Gangrene (HP:0100758)2.17400344
89Thoracic kyphosis (HP:0002942)2.16046053
90Personality changes (HP:0000751)2.14228478
91Pulmonary embolism (HP:0002204)2.12447302
92Chest pain (HP:0100749)2.11437158
93Nuclear cataract (HP:0100018)2.10914278
94Neuronal loss in central nervous system (HP:0002529)2.09399238
95Malnutrition (HP:0004395)2.08810470
96Epistaxis (HP:0000421)2.08676191
97Neurofibrillary tangles (HP:0002185)2.05077615
98Episodic fever (HP:0001954)2.04601469
99Pulmonary infiltrates (HP:0002113)2.04048272
100Abnormal delayed hypersensitivity skin test (HP:0002963)2.02685622
101Abnormality of the prostate (HP:0008775)2.02136161
102Vasculitis (HP:0002633)1.99920705
103Joint hemorrhage (HP:0005261)1.98937079
104Progressive neurologic deterioration (HP:0002344)1.97854217
105Arterial thrombosis (HP:0004420)1.97250064
106Cerebral inclusion bodies (HP:0100314)1.96742916
107Anorexia (HP:0002039)1.95279666
108Leukocytosis (HP:0001974)1.93139830
109Petechiae (HP:0000967)1.92589688
110Gingival bleeding (HP:0000225)1.90566897
111Vertebral compression fractures (HP:0002953)1.90405013
112Memory impairment (HP:0002354)1.90279882
113Increased IgE level (HP:0003212)1.89692274
114Vascular tortuosity (HP:0004948)1.89303467
115Abnormality of the pleura (HP:0002103)1.86979011
116Hypergammaglobulinemia (HP:0010702)1.86221726
117Asymmetric septal hypertrophy (HP:0001670)1.83629385
118Spinal muscular atrophy (HP:0007269)1.83598361
119Increased CSF protein (HP:0002922)1.83432834
120Meningitis (HP:0001287)1.79910242
121Colitis (HP:0002583)1.79494724
122Recurrent lower respiratory tract infections (HP:0002783)1.76516157
123Eosinophilia (HP:0001880)1.74463711
124Interstitial pulmonary disease (HP:0006530)1.74391465
125Hypercholesterolemia (HP:0003124)1.73812048
126Chronic mucocutaneous candidiasis (HP:0002728)1.72231370
127Recurrent cutaneous fungal infections (HP:0011370)1.72231370
128Impaired platelet aggregation (HP:0003540)1.71734076
129Abnormal platelet function (HP:0011869)1.71734076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.38472610
2TGFBR24.08152986
3KIT3.37384479
4IRAK43.35633407
5TYK23.27944432
6RIPK43.21934981
7MAP3K143.12419820
8TBK12.99637660
9GRK72.87279154
10IRAK32.72729802
11NEK92.47583427
12MAP4K12.10591186
13IKBKB1.93702369
14IKBKE1.93662529
15ERN11.87388314
16JAK11.85968163
17CSF1R1.82718432
18PRPF4B1.76540063
19CAMK1D1.69955810
20HCK1.66487116
21ZAP701.65081121
22TAOK31.59457326
23CSK1.54208973
24STK101.53253736
25FES1.51868231
26TXK1.50412368
27LYN1.50271858
28SYK1.47627446
29TAOK11.44814148
30PBK1.44366936
31ITK1.43874142
32TAOK21.42816813
33BTK1.33221100
34DDR21.29908437
35MAP3K131.27875857
36LCK1.27813000
37JAK31.24450593
38EPHB11.21899886
39PIM21.21472746
40FGR1.19420196
41MOS1.18035189
42SCYL21.16643426
43ACVR1B1.14124388
44JAK21.13924074
45TNK21.13748548
46MAP3K11.12838358
47CDC42BPA1.10638475
48MATK1.07500802
49CAMK1G1.07460606
50TEC1.07061526
51TESK21.03747658
52CAMKK21.03043817
53TTN0.99238116
54SIK20.98894805
55CHUK0.97649385
56ADRBK20.95752600
57EGFR0.93783843
58YES10.92520785
59CDK60.91740214
60SIK30.89701115
61PLK20.88949937
62NME20.88728101
63MAP2K30.82589057
64BMPR20.81945607
65PDK20.77803959
66DAPK20.77148274
67MARK30.77113713
68GRK60.76938699
69EIF2AK20.76593508
70PRKCD0.73395469
71PDPK10.71105306
72CLK10.69797664
73ABL10.67793512
74FGFR30.66248069
75CAMKK10.66209294
76RPS6KA40.64791669
77PIM10.62157710
78TRPM70.61407397
79KSR20.60904148
80MAP3K30.58720574
81PAK40.57771012
82STK40.56434519
83FYN0.55525504
84ABL20.55366833
85MAPKAPK20.54515562
86RIPK10.52993789
87MARK20.52275938
88MAP3K60.51801884
89STK30.49959613
90MAP2K60.49912964
91IGF1R0.49695881
92FGFR40.46061551
93IRAK20.44079218
94PIK3CG0.42065413
95MAP3K110.41027711
96MAPK70.39982260
97PKN20.39532543
98PTK60.39417092
99NUAK10.39050976
100EPHA30.39030836
101ERBB30.37988768
102PRKD20.37504288
103ARAF0.35188636
104MAP3K50.34854361
105PDGFRB0.33846633
106IRAK10.32761787
107BMX0.32689172
108CDK120.32494730
109PRKG20.30881696
110RPS6KA20.30667969
111KSR10.30532681
112RPS6KA60.30240631
113SRC0.30120398
114MAPK40.29515302
115PRKCQ0.29511921
116GSK3A0.29220068
117MAPK120.27737491
118MAP3K20.27556752
119RPS6KL10.26328447
120RPS6KC10.26328447
121PDK10.25901035
122INSR0.24791428
123PRKG10.20902719
124DMPK0.20887398

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051504.34114654
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.82956743
3Lysosome_Homo sapiens_hsa041423.81008874
4Other glycan degradation_Homo sapiens_hsa005113.14480408
5Leishmaniasis_Homo sapiens_hsa051403.03088891
6Osteoclast differentiation_Homo sapiens_hsa043802.77557384
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73521200
8Pertussis_Homo sapiens_hsa051332.58404991
9Phagosome_Homo sapiens_hsa041452.35755666
10Tuberculosis_Homo sapiens_hsa051522.30991447
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.00002340
12B cell receptor signaling pathway_Homo sapiens_hsa046621.97323275
13Rheumatoid arthritis_Homo sapiens_hsa053231.93082826
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91469609
15Legionellosis_Homo sapiens_hsa051341.89061260
16Antigen processing and presentation_Homo sapiens_hsa046121.87127459
17Malaria_Homo sapiens_hsa051441.87072085
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.75418619
19Measles_Homo sapiens_hsa051621.66170316
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60838792
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59842446
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57609323
23Salmonella infection_Homo sapiens_hsa051321.55404637
24Toxoplasmosis_Homo sapiens_hsa051451.48425832
25Influenza A_Homo sapiens_hsa051641.42112212
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42046161
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38370347
28Apoptosis_Homo sapiens_hsa042101.33359533
29* Complement and coagulation cascades_Homo sapiens_hsa046101.32715948
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29010214
31Chemokine signaling pathway_Homo sapiens_hsa040621.23832602
32Prion diseases_Homo sapiens_hsa050201.22930749
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19081604
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17934060
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14505571
36Asthma_Homo sapiens_hsa053101.12747529
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.12286582
38Shigellosis_Homo sapiens_hsa051311.10417892
39Hematopoietic cell lineage_Homo sapiens_hsa046401.08638509
40Graft-versus-host disease_Homo sapiens_hsa053321.06384365
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04363206
42Allograft rejection_Homo sapiens_hsa053301.04267170
43Sphingolipid metabolism_Homo sapiens_hsa006001.02944513
44TNF signaling pathway_Homo sapiens_hsa046681.01780551
45Hepatitis B_Homo sapiens_hsa051611.00179516
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00002331
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96023277
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94438488
49Herpes simplex infection_Homo sapiens_hsa051680.92934198
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.89819245
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.87489427
52Amoebiasis_Homo sapiens_hsa051460.83585964
53Hepatitis C_Homo sapiens_hsa051600.83288759
54Pancreatic cancer_Homo sapiens_hsa052120.81923558
55Mineral absorption_Homo sapiens_hsa049780.79641420
56Chronic myeloid leukemia_Homo sapiens_hsa052200.79343108
57Endocytosis_Homo sapiens_hsa041440.79251886
58Collecting duct acid secretion_Homo sapiens_hsa049660.78464967
59Caffeine metabolism_Homo sapiens_hsa002320.75352492
60Viral myocarditis_Homo sapiens_hsa054160.73908350
61Platelet activation_Homo sapiens_hsa046110.73874514
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73197488
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.68448924
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67695060
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65123444
66African trypanosomiasis_Homo sapiens_hsa051430.63320510
67T cell receptor signaling pathway_Homo sapiens_hsa046600.62522352
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58649303
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.51665666
70Renin-angiotensin system_Homo sapiens_hsa046140.51597123
71Acute myeloid leukemia_Homo sapiens_hsa052210.51373066
72Bladder cancer_Homo sapiens_hsa052190.51118866
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.49882161
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48827880
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47326299
76HIF-1 signaling pathway_Homo sapiens_hsa040660.45937487
77Autoimmune thyroid disease_Homo sapiens_hsa053200.42586408
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42049266
79Prolactin signaling pathway_Homo sapiens_hsa049170.41914723
80Primary immunodeficiency_Homo sapiens_hsa053400.41736258
81Galactose metabolism_Homo sapiens_hsa000520.40448535
82Proteoglycans in cancer_Homo sapiens_hsa052050.39719224
83Notch signaling pathway_Homo sapiens_hsa043300.37651458
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35519677
85Renal cell carcinoma_Homo sapiens_hsa052110.35270635
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34137621
87Steroid biosynthesis_Homo sapiens_hsa001000.33808202
88Type II diabetes mellitus_Homo sapiens_hsa049300.33722048
89PPAR signaling pathway_Homo sapiens_hsa033200.32513606
90HTLV-I infection_Homo sapiens_hsa051660.31947305
91VEGF signaling pathway_Homo sapiens_hsa043700.29294945
92Small cell lung cancer_Homo sapiens_hsa052220.28631380
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28580439
94Viral carcinogenesis_Homo sapiens_hsa052030.27682717
95GnRH signaling pathway_Homo sapiens_hsa049120.26911605
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26693076
97Epstein-Barr virus infection_Homo sapiens_hsa051690.26540250
98Vibrio cholerae infection_Homo sapiens_hsa051100.26459401
99Type I diabetes mellitus_Homo sapiens_hsa049400.25985829
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.25893705
101Arachidonic acid metabolism_Homo sapiens_hsa005900.23642059
102Glioma_Homo sapiens_hsa052140.22526567
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21732903
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20846417
105Ether lipid metabolism_Homo sapiens_hsa005650.20400487
106Systemic lupus erythematosus_Homo sapiens_hsa053220.20260142
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19481818
108Dorso-ventral axis formation_Homo sapiens_hsa043200.18894314
109Non-small cell lung cancer_Homo sapiens_hsa052230.18792669
110Synaptic vesicle cycle_Homo sapiens_hsa047210.15250177
111MAPK signaling pathway_Homo sapiens_hsa040100.14952952
112Insulin resistance_Homo sapiens_hsa049310.14716293

Most similar genes based on co-expression Upload to Enrichr

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