ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	4.31655632
2	presynaptic membrane organization (GO:0097090)	3.92793383
3	neuron cell-cell adhesion (GO:0007158)	3.65639565
4	neurotransmitter-gated ion channel clustering (GO:0072578)	3.61143631
5	pyrimidine nucleobase catabolic process (GO:0006208)	3.42704194
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.39726177
7	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.37612303
8	postsynaptic membrane organization (GO:0001941)	3.29636980
9	protein complex biogenesis (GO:0070271)	3.26567635
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.13731908
11	nonmotile primary cilium assembly (GO:0035058)	3.12688712
12	nucleobase catabolic process (GO:0046113)	3.10830244
13	axonal fasciculation (GO:0007413)	3.06760853
14	protein localization to cilium (GO:0061512)	3.01777491
15	behavioral response to nicotine (GO:0035095)	2.99988674
16	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99323546
17	protein neddylation (GO:0045116)	2.95457819
18	protein localization to synapse (GO:0035418)	2.92856455
19	water-soluble vitamin biosynthetic process (GO:0042364)	2.92374075
20	vocalization behavior (GO:0071625)	2.87750984
21	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.85905751
22	regulation of glucokinase activity (GO:0033131)	2.85284495
23	regulation of hexokinase activity (GO:1903299)	2.85284495
24	neuron fate determination (GO:0048664)	2.84214309
25	glycosphingolipid biosynthetic process (GO:0006688)	2.81873655
26	auditory behavior (GO:0031223)	2.81832742
27	retinal ganglion cell axon guidance (GO:0031290)	2.81534535
28	dendritic spine morphogenesis (GO:0060997)	2.80213752
29	cullin deneddylation (GO:0010388)	2.79202595
30	inositol phosphate catabolic process (GO:0071545)	2.77847505
31	neuron recognition (GO:0008038)	2.75532985
32	respiratory chain complex IV assembly (GO:0008535)	2.75509348
33	NADH dehydrogenase complex assembly (GO:0010257)	2.72618447
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.72618447
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.72618447
36	ATP synthesis coupled proton transport (GO:0015986)	2.72378843
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.72378843
38	electron transport chain (GO:0022900)	2.70004118
39	respiratory electron transport chain (GO:0022904)	2.68328421
40	transmission of nerve impulse (GO:0019226)	2.68038718
41	synapse assembly (GO:0007416)	2.67237227
42	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.66975521
43	neuronal action potential propagation (GO:0019227)	2.66927437
44	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.66512414
45	substrate-independent telencephalic tangential migration (GO:0021826)	2.66512414
46	glutamate receptor signaling pathway (GO:0007215)	2.66511580
47	gamma-aminobutyric acid transport (GO:0015812)	2.66311087
48	DNA double-strand break processing (GO:0000729)	2.65731883
49	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.65024245
50	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.61026775
51	regulation of cilium movement (GO:0003352)	2.59255556
52	detection of calcium ion (GO:0005513)	2.58983503
53	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.58332195
54	startle response (GO:0001964)	2.58052424
55	neurotransmitter secretion (GO:0007269)	2.55992645
56	protein deneddylation (GO:0000338)	2.55187473
57	synaptic vesicle maturation (GO:0016188)	2.54886305
58	protein-cofactor linkage (GO:0018065)	2.53898236
59	synaptic transmission, glutamatergic (GO:0035249)	2.53092409
60	neuron-neuron synaptic transmission (GO:0007270)	2.52040308
61	regulation of action potential (GO:0098900)	2.51234288
62	intraciliary transport (GO:0042073)	2.50691985
63	cellular ketone body metabolic process (GO:0046950)	2.49518661
64	epithelial cilium movement (GO:0003351)	2.47944107
65	response to pheromone (GO:0019236)	2.46234446
66	negative regulation of dendrite development (GO:2000171)	2.45915409
67	mechanosensory behavior (GO:0007638)	2.45682690
68	proteasome assembly (GO:0043248)	2.44564234
69	cytochrome complex assembly (GO:0017004)	2.44392454
70	positive regulation of mitochondrial fission (GO:0090141)	2.40303970
71	limb bud formation (GO:0060174)	2.39858661
72	cilium morphogenesis (GO:0060271)	2.39743368
73	establishment of melanosome localization (GO:0032401)	2.37432150
74	platelet dense granule organization (GO:0060155)	2.35544188
75	melanosome transport (GO:0032402)	2.35405589
76	glutamate secretion (GO:0014047)	2.35084529
77	positive regulation of action potential (GO:0045760)	2.34360229
78	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.32547553
79	neural tube formation (GO:0001841)	2.30405704
80	retinal cone cell development (GO:0046549)	2.30014849
81	keratinocyte development (GO:0003334)	2.29602599
82	response to amphetamine (GO:0001975)	2.28755520
83	cilium assembly (GO:0042384)	2.28271336
84	positive regulation of amino acid transport (GO:0051957)	2.27070596
85	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.26470654
86	glycerophospholipid catabolic process (GO:0046475)	2.26444445
87	peptidyl-histidine modification (GO:0018202)	2.26407150
88	neuronal action potential (GO:0019228)	2.25597172
89	cilium organization (GO:0044782)	2.25448827
90	establishment of pigment granule localization (GO:0051905)	2.25254588
91	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.24632856
92	proline transport (GO:0015824)	2.23933182
93	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.23087177
94	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.22882082
95	ATP hydrolysis coupled proton transport (GO:0015991)	2.22882082
96	pigment granule transport (GO:0051904)	2.22766618
97	reflex (GO:0060004)	2.22305431
98	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.22141306
99	neuron fate specification (GO:0048665)	2.21941185
100	regulation of timing of cell differentiation (GO:0048505)	2.21690719

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.12454499
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.03119465
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.92039628
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89744081
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.80686297
6	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71939621
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.51934188
8	VDR_22108803_ChIP-Seq_LS180_Human	2.39532430
9	FUS_26573619_Chip-Seq_HEK293_Human	2.36445564
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34202130
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33633195
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.29708974
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28626751
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.10780620
15	EWS_26573619_Chip-Seq_HEK293_Human	2.04403780
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.03426903
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.03377834
18	* P300_19829295_ChIP-Seq_ESCs_Human	2.03188725
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02552379
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.95319911
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93976539
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90631531
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.80156211
24	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.76644542
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76200099
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.75744552
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.75102703
28	* ER_23166858_ChIP-Seq_MCF-7_Human	1.73638351
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.73276133
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.70847519
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70286999
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67272440
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61799325
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59622846
35	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56789750
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55805757
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52542723
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49829681
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49452977
40	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49289984
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48018613
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47894065
43	* AR_25329375_ChIP-Seq_VCAP_Human	1.44763310
44	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.40518968
45	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39231497
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39165998
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.37249459
48	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37164242
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37143399
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35991842
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35985884
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35496553
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34640185
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.34267828
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33744792
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33050733
57	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.29201831
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.27938712
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26677097
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24634329
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.24634329
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20859458
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20859458
64	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20783848
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19774544
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19008378
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17697554
68	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.17380364
69	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16966030
70	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.16463243
71	* STAT3_23295773_ChIP-Seq_U87_Human	1.16148748
72	HTT_18923047_ChIP-ChIP_STHdh_Human	1.16003124
73	TCF4_23295773_ChIP-Seq_U87_Human	1.14976401
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.14517316
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13813718
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11037252
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11031144
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10425700
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.09908549
80	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09239945
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08336134
82	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.07049332
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07030078
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06382516
85	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05310274
86	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05229890
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05029674
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03749943
89	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.03526347
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03310541
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03117199
92	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.03096532
93	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02024126
94	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02024126
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01213596
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00647410
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00038578
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99607224
99	JUN_21703547_ChIP-Seq_K562_Human	0.97740206
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97604294

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.82253090
2	MP0004270_analgesia	2.95860716
3	MP0003787_abnormal_imprinting	2.85113097
4	MP0001529_abnormal_vocalization	2.71116011
5	MP0009046_muscle_twitch	2.44678468
6	MP0002837_dystrophic_cardiac_calcinosis	2.33526304
7	MP0001968_abnormal_touch/_nociception	2.29770539
8	MP0003122_maternal_imprinting	2.22695325
9	MP0008877_abnormal_DNA_methylation	2.21624235
10	MP0009745_abnormal_behavioral_response	2.11902487
11	MP0002736_abnormal_nociception_after	2.09674280
12	MP0002909_abnormal_adrenal_gland	2.09539614
13	MP0002102_abnormal_ear_morphology	2.08767876
14	MP0001984_abnormal_olfaction	2.03597855
15	MP0002272_abnormal_nervous_system	2.02476259
16	MP0006276_abnormal_autonomic_nervous	2.00311845
17	MP0009780_abnormal_chondrocyte_physiolo	1.98308248
18	MP0004859_abnormal_synaptic_plasticity	1.96299199
19	MP0006072_abnormal_retinal_apoptosis	1.94923341
20	MP0003635_abnormal_synaptic_transmissio	1.88670200
21	MP0002638_abnormal_pupillary_reflex	1.87037014
22	MP0002734_abnormal_mechanical_nocicepti	1.84968450
23	MP0003121_genomic_imprinting	1.84551641
24	MP0002064_seizures	1.77003643
25	MP0001486_abnormal_startle_reflex	1.76328943
26	MP0000778_abnormal_nervous_system	1.70060235
27	MP0010386_abnormal_urinary_bladder	1.68306869
28	MP0005646_abnormal_pituitary_gland	1.68183093
29	MP0002572_abnormal_emotion/affect_behav	1.65277342
30	MP0002063_abnormal_learning/memory/cond	1.64367111
31	MP0003195_calcinosis	1.60619935
32	MP0008789_abnormal_olfactory_epithelium	1.60607973
33	MP0000569_abnormal_digit_pigmentation	1.56722429
34	MP0005551_abnormal_eye_electrophysiolog	1.54904518
35	MP0003011_delayed_dark_adaptation	1.54774733
36	MP0005253_abnormal_eye_physiology	1.53900799
37	MP0002735_abnormal_chemical_nociception	1.52804443
38	MP0002184_abnormal_innervation	1.50525023
39	MP0002557_abnormal_social/conspecific_i	1.49958087
40	MP0002822_catalepsy	1.47010150
41	MP0005379_endocrine/exocrine_gland_phen	1.43660358
42	MP0002751_abnormal_autonomic_nervous	1.43626306
43	MP0005499_abnormal_olfactory_system	1.38581976
44	MP0005394_taste/olfaction_phenotype	1.38581976
45	MP0005386_behavior/neurological_phenoty	1.38443836
46	MP0004924_abnormal_behavior	1.38443836
47	MP0005084_abnormal_gallbladder_morpholo	1.37653547
48	MP0005423_abnormal_somatic_nervous	1.35455966
49	MP0000631_abnormal_neuroendocrine_gland	1.34534797
50	MP0004133_heterotaxia	1.33906772
51	MP0002067_abnormal_sensory_capabilities	1.33085262
52	MP0001905_abnormal_dopamine_level	1.32382191
53	MP0004885_abnormal_endolymph	1.32153542
54	MP0001970_abnormal_pain_threshold	1.31306320
55	MP0005645_abnormal_hypothalamus_physiol	1.29914062
56	MP0006292_abnormal_olfactory_placode	1.27645173
57	MP0004142_abnormal_muscle_tone	1.27507026
58	MP0002938_white_spotting	1.20430541
59	MP0001485_abnormal_pinna_reflex	1.18488415
60	MP0003123_paternal_imprinting	1.17899376
61	MP0004043_abnormal_pH_regulation	1.16683141
62	MP0001188_hyperpigmentation	1.15185974
63	MP0005187_abnormal_penis_morphology	1.14194270
64	MP0002163_abnormal_gland_morphology	1.13690611
65	MP0001501_abnormal_sleep_pattern	1.12392212
66	MP0002733_abnormal_thermal_nociception	1.11764681
67	MP0002234_abnormal_pharynx_morphology	1.11149720
68	MP0000427_abnormal_hair_cycle	1.09761963
69	MP0001944_abnormal_pancreas_morphology	1.09077773
70	MP0002882_abnormal_neuron_morphology	1.08673654
71	MP0000955_abnormal_spinal_cord	1.08342754
72	MP0004147_increased_porphyrin_level	1.03623490
73	MP0004742_abnormal_vestibular_system	1.02589318
74	MP0002653_abnormal_ependyma_morphology	1.01176909
75	MP0008995_early_reproductive_senescence	0.98387768
76	MP0002090_abnormal_vision	0.98336827
77	MP0000538_abnormal_urinary_bladder	0.97428094
78	MP0000516_abnormal_urinary_system	0.97303937
79	MP0005367_renal/urinary_system_phenotyp	0.97303937
80	MP0004811_abnormal_neuron_physiology	0.95898616
81	MP0008872_abnormal_physiological_respon	0.95854475
82	MP0002752_abnormal_somatic_nervous	0.95193615
83	MP0003890_abnormal_embryonic-extraembry	0.95003263
84	MP0002928_abnormal_bile_duct	0.94705358
85	MP0008058_abnormal_DNA_repair	0.93367731
86	MP0000647_abnormal_sebaceous_gland	0.91831160
87	MP0003718_maternal_effect	0.90612496
88	MP0002160_abnormal_reproductive_system	0.90407766
89	MP0002066_abnormal_motor_capabilities/c	0.87935210
90	MP0002229_neurodegeneration	0.87384593
91	MP0003283_abnormal_digestive_organ	0.85638898
92	MP0002069_abnormal_eating/drinking_beha	0.85574363
93	MP0005248_abnormal_Harderian_gland	0.83022010
94	MP0001440_abnormal_grooming_behavior	0.82402207
95	MP0002693_abnormal_pancreas_physiology	0.82238137
96	MP0004215_abnormal_myocardial_fiber	0.80911629
97	MP0002152_abnormal_brain_morphology	0.80616945
98	MP0003137_abnormal_impulse_conducting	0.79806730
99	MP0000372_irregular_coat_pigmentation	0.78610692
100	MP0003119_abnormal_digestive_system	0.77340905

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.52971263
2	Progressive macrocephaly (HP:0004481)	3.40414929
3	Medial flaring of the eyebrow (HP:0010747)	3.34827413
4	Hypothermia (HP:0002045)	3.19650741
5	Gait imbalance (HP:0002141)	3.09290373
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.06303370
7	Limb dystonia (HP:0002451)	3.03052967
8	Acute encephalopathy (HP:0006846)	3.00968031
9	Pancreatic cysts (HP:0001737)	2.88843155
10	Pancreatic fibrosis (HP:0100732)	2.87821646
11	Mitochondrial inheritance (HP:0001427)	2.86425392
12	Focal motor seizures (HP:0011153)	2.86286122
13	Febrile seizures (HP:0002373)	2.85001856
14	Congenital primary aphakia (HP:0007707)	2.84865312
15	Hyperventilation (HP:0002883)	2.83773209
16	Myokymia (HP:0002411)	2.80377350
17	Molar tooth sign on MRI (HP:0002419)	2.78253733
18	Abnormality of midbrain morphology (HP:0002418)	2.78253733
19	True hermaphroditism (HP:0010459)	2.75891343
20	Abnormality of the labia minora (HP:0012880)	2.70733325
21	Methylmalonic acidemia (HP:0002912)	2.70198004
22	Nephrogenic diabetes insipidus (HP:0009806)	2.67779346
23	Increased CSF lactate (HP:0002490)	2.64241726
24	Hepatic necrosis (HP:0002605)	2.63195845
25	Agitation (HP:0000713)	2.59923080
26	Broad-based gait (HP:0002136)	2.54378151
27	Focal seizures (HP:0007359)	2.48407965
28	Nephronophthisis (HP:0000090)	2.48283345
29	Genital tract atresia (HP:0001827)	2.46657905
30	Poor suck (HP:0002033)	2.45145851
31	Hepatocellular necrosis (HP:0001404)	2.45082519
32	Epileptic encephalopathy (HP:0200134)	2.44164622
33	Intestinal atresia (HP:0011100)	2.43324627
34	Hemiparesis (HP:0001269)	2.36864885
35	Vaginal atresia (HP:0000148)	2.36703555
36	Drooling (HP:0002307)	2.36211230
37	Hypoglycemic coma (HP:0001325)	2.35861181
38	Renal cortical cysts (HP:0000803)	2.35443893
39	Lissencephaly (HP:0001339)	2.31980221
40	Atonic seizures (HP:0010819)	2.30591880
41	Dialeptic seizures (HP:0011146)	2.29743738
42	Polyphagia (HP:0002591)	2.27894402
43	Progressive cerebellar ataxia (HP:0002073)	2.27686590
44	Increased hepatocellular lipid droplets (HP:0006565)	2.27222673
45	Type II lissencephaly (HP:0007260)	2.26975908
46	Methylmalonic aciduria (HP:0012120)	2.22710842
47	EEG with generalized epileptiform discharges (HP:0011198)	2.21792588
48	Epileptiform EEG discharges (HP:0011182)	2.20842215
49	Hypsarrhythmia (HP:0002521)	2.18977428
50	Ketoacidosis (HP:0001993)	2.14400364
51	Lipid accumulation in hepatocytes (HP:0006561)	2.13655607
52	Muscular hypotonia of the trunk (HP:0008936)	2.10707193
53	Abnormality of the renal cortex (HP:0011035)	2.08249224
54	Excessive salivation (HP:0003781)	2.08142533
55	Cerebral edema (HP:0002181)	2.07549708
56	3-Methylglutaconic aciduria (HP:0003535)	2.01454821
57	Generalized tonic-clonic seizures (HP:0002069)	2.00341621
58	Absence seizures (HP:0002121)	1.98839489
59	Abnormality of the renal medulla (HP:0100957)	1.96148899
60	Abnormality of vitamin B metabolism (HP:0004340)	1.95477610
61	Poor coordination (HP:0002370)	1.93979565
62	Pachygyria (HP:0001302)	1.93871144
63	Hyperinsulinemic hypoglycemia (HP:0000825)	1.93564661
64	Inability to walk (HP:0002540)	1.92897015
65	Absent speech (HP:0001344)	1.92226108
66	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.91432069
67	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.91432069
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.86596330
69	Hyperglycinemia (HP:0002154)	1.85768769
70	Neoplasm of the adrenal cortex (HP:0100641)	1.85601948
71	Optic disc pallor (HP:0000543)	1.84946959
72	Gaze-evoked nystagmus (HP:0000640)	1.83457645
73	Spastic tetraplegia (HP:0002510)	1.81684093
74	Renal Fanconi syndrome (HP:0001994)	1.80839786
75	Hypomagnesemia (HP:0002917)	1.80718542
76	Specific learning disability (HP:0001328)	1.79722625
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78851167
78	Sclerocornea (HP:0000647)	1.78155300
79	Progressive inability to walk (HP:0002505)	1.75957269
80	Postaxial hand polydactyly (HP:0001162)	1.75561810
81	Pendular nystagmus (HP:0012043)	1.75445990
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.74353976
83	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.74353976
84	Abnormality of the corticospinal tract (HP:0002492)	1.73527683
85	Action tremor (HP:0002345)	1.73430359
86	Respiratory failure (HP:0002878)	1.71835719
87	Generalized aminoaciduria (HP:0002909)	1.69744853
88	Congenital stationary night blindness (HP:0007642)	1.69514683
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69076834
90	Abolished electroretinogram (ERG) (HP:0000550)	1.65763819
91	Furrowed tongue (HP:0000221)	1.64503173
92	Retinal dysplasia (HP:0007973)	1.64170626
93	Narrow forehead (HP:0000341)	1.63956714
94	Delayed gross motor development (HP:0002194)	1.62666112
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.61923247
96	Severe muscular hypotonia (HP:0006829)	1.60580839
97	Hypoglycemic seizures (HP:0002173)	1.60261954
98	Ketosis (HP:0001946)	1.60023893
99	Anencephaly (HP:0002323)	1.59993060
100	Decreased testicular size (HP:0008734)	1.59685844

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.19842301
2	FRK	3.79974304
3	CASK	3.53735241
4	MARK1	3.09729842
5	MAP4K2	2.67696489
6	TRIM28	2.65776004
7	MAP3K4	2.51501711
8	MAPK13	2.32618540
9	BCR	2.14206323
10	MAP2K7	2.03753870
11	NTRK3	1.99383321
12	EPHA4	1.84324541
13	NEK1	1.56119963
14	ADRBK2	1.55183218
15	CSNK1G2	1.55181770
16	BMPR1B	1.53108777
17	PNCK	1.50698413
18	DYRK2	1.47668305
19	MAP3K12	1.45557868
20	CSNK1G3	1.44974301
21	ERBB3	1.43204958
22	LIMK1	1.42790293
23	PAK3	1.40359384
24	PINK1	1.40288659
25	PHKG2	1.37990856
26	PHKG1	1.37990856
27	CSNK1G1	1.34926306
28	MINK1	1.34221701
29	PLK2	1.31276784
30	VRK2	1.28207014
31	PRKCG	1.26767633
32	MKNK2	1.26633826
33	FGFR2	1.25872365
34	UHMK1	1.23400269
35	DAPK2	1.22157624
36	MUSK	1.21848789
37	TNIK	1.20901218
38	CCNB1	1.18410241
39	CSNK1A1L	1.12824408
40	NTRK2	1.11843914
41	GRK1	1.11596746
42	PRKCE	1.11415509
43	INSRR	1.09872334
44	VRK1	1.09700061
45	MST4	1.09601434
46	ZAK	1.07455063
47	PLK3	1.03329645
48	EIF2AK3	1.00627221
49	NUAK1	1.00081637
50	STK16	0.98586919
51	SRPK1	0.96479616
52	TSSK6	0.93875364
53	OXSR1	0.88131497
54	BCKDK	0.87922349
55	CAMK2A	0.83442667
56	BUB1	0.79637020
57	DYRK3	0.79521180
58	TESK1	0.79069422
59	MAP2K4	0.75057881
60	CAMK2B	0.73302922
61	CAMK2D	0.68748126
62	EPHA3	0.68581719
63	RPS6KA4	0.61697011
64	PRKCI	0.60262579
65	DYRK1A	0.57896215
66	EIF2AK1	0.57300550
67	MKNK1	0.56921294
68	PIK3CA	0.56339686
69	GRK5	0.55808055
70	FER	0.54938559
71	CDK3	0.54624510
72	CDK5	0.54607574
73	STK39	0.53769793
74	PRKCZ	0.53001776
75	NME1	0.50415743
76	CSNK1A1	0.50198036
77	SIK2	0.49460744
78	PKN1	0.49364025
79	PAK6	0.48282969
80	STK38L	0.47430997
81	CAMK2G	0.45854348
82	DAPK1	0.44202410
83	PLK1	0.43467994
84	PRKACA	0.41901863
85	SIK3	0.40858134
86	CSNK1E	0.40689977
87	CSNK1D	0.40248129
88	RPS6KA5	0.40123390
89	WNK4	0.39807297
90	PLK4	0.39522714
91	TAOK1	0.39506945
92	PRKACB	0.39358865
93	PRKG1	0.39068278
94	CDK14	0.38652058
95	ADRBK1	0.37840292
96	STK11	0.37594668
97	WEE1	0.37526135
98	ACVR1B	0.35921404
99	TAOK3	0.34674370
100	TAF1	0.32355809

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49258625
2	Protein export_Homo sapiens_hsa03060	3.41679918
3	Nicotine addiction_Homo sapiens_hsa05033	2.79196085
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76556967
5	Parkinsons disease_Homo sapiens_hsa05012	2.76534295
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.64847229
7	Butanoate metabolism_Homo sapiens_hsa00650	2.18066964
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97233378
9	Alzheimers disease_Homo sapiens_hsa05010	1.94938743
10	GABAergic synapse_Homo sapiens_hsa04727	1.91825030
11	Collecting duct acid secretion_Homo sapiens_hsa04966	1.83272365
12	Huntingtons disease_Homo sapiens_hsa05016	1.81759968
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.80917686
14	Phototransduction_Homo sapiens_hsa04744	1.79875148
15	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.79230523
16	Proteasome_Homo sapiens_hsa03050	1.73765269
17	Insulin secretion_Homo sapiens_hsa04911	1.67863644
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.64750478
19	Propanoate metabolism_Homo sapiens_hsa00640	1.62555327
20	RNA polymerase_Homo sapiens_hsa03020	1.61305823
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.61119091
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.58585113
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.54838082
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.54394647
25	Morphine addiction_Homo sapiens_hsa05032	1.53333033
26	Folate biosynthesis_Homo sapiens_hsa00790	1.52908171
27	Circadian entrainment_Homo sapiens_hsa04713	1.52850659
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.52559614
29	Amphetamine addiction_Homo sapiens_hsa05031	1.44024950
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42433923
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41090777
32	Taste transduction_Homo sapiens_hsa04742	1.36142958
33	Basal transcription factors_Homo sapiens_hsa03022	1.34929567
34	Fatty acid elongation_Homo sapiens_hsa00062	1.32525887
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31025081
36	Sulfur metabolism_Homo sapiens_hsa00920	1.29523111
37	Cocaine addiction_Homo sapiens_hsa05030	1.18456453
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16984575
39	Regulation of autophagy_Homo sapiens_hsa04140	1.09934722
40	RNA degradation_Homo sapiens_hsa03018	1.08628136
41	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.05289453
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05087603
43	Vibrio cholerae infection_Homo sapiens_hsa05110	1.04243762
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.00562391
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98462813
46	Serotonergic synapse_Homo sapiens_hsa04726	0.98356296
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94948423
48	Long-term depression_Homo sapiens_hsa04730	0.92848030
49	Peroxisome_Homo sapiens_hsa04146	0.92740845
50	Oocyte meiosis_Homo sapiens_hsa04114	0.90300820
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.87820043
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.87638797
53	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.76969275
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.76853455
55	Salivary secretion_Homo sapiens_hsa04970	0.75676836
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.73772492
57	Renin secretion_Homo sapiens_hsa04924	0.72552155
58	Olfactory transduction_Homo sapiens_hsa04740	0.71936835
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69756657
60	Metabolic pathways_Homo sapiens_hsa01100	0.68413380
61	Purine metabolism_Homo sapiens_hsa00230	0.68211794
62	Homologous recombination_Homo sapiens_hsa03440	0.67932764
63	Circadian rhythm_Homo sapiens_hsa04710	0.67654265
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64802958
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.60746833
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60660210
67	Cholinergic synapse_Homo sapiens_hsa04725	0.59055109
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58740333
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58409755
70	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57053688
71	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56123885
72	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55339323
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.55227672
74	Caffeine metabolism_Homo sapiens_hsa00232	0.54840104
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52955768
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.51038899
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49899483
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.49863940
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48291230
80	One carbon pool by folate_Homo sapiens_hsa00670	0.47389406
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46089280
82	RNA transport_Homo sapiens_hsa03013	0.44158521
83	Gastric acid secretion_Homo sapiens_hsa04971	0.44152232
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43152494
85	Axon guidance_Homo sapiens_hsa04360	0.42891557
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42566272
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41736406
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40530423
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36059215
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34214725
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.33685322
92	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33257283
93	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.32419913
94	Retinol metabolism_Homo sapiens_hsa00830	0.32313931
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.32268218
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32246120
97	Mineral absorption_Homo sapiens_hsa04978	0.31206186
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.31196554
99	Spliceosome_Homo sapiens_hsa03040	0.29734492
100	Glucagon signaling pathway_Homo sapiens_hsa04922	0.29349948

C3ORF14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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