Rank | Gene Set | Z-score |
---|---|---|
1 | sperm motility (GO:0030317) | 9.08621175 |
2 | fusion of sperm to egg plasma membrane (GO:0007342) | 8.22027015 |
3 | acrosome reaction (GO:0007340) | 8.06050058 |
4 | spermatid nucleus differentiation (GO:0007289) | 7.94743465 |
5 | single strand break repair (GO:0000012) | 7.61876111 |
6 | microtubule depolymerization (GO:0007019) | 7.32111835 |
7 | chromosome condensation (GO:0030261) | 7.17603925 |
8 | DNA packaging (GO:0006323) | 7.11389234 |
9 | multicellular organism reproduction (GO:0032504) | 6.80500273 |
10 | sperm capacitation (GO:0048240) | 6.66327017 |
11 | response to pheromone (GO:0019236) | 6.43792719 |
12 | sperm-egg recognition (GO:0035036) | 6.22745080 |
13 | reproduction (GO:0000003) | 6.12267222 |
14 | plasma membrane fusion (GO:0045026) | 6.04223202 |
15 | negative regulation of inclusion body assembly (GO:0090084) | 5.80687118 |
16 | spermatid development (GO:0007286) | 5.80187528 |
17 | rRNA methylation (GO:0031167) | 5.67717440 |
18 | binding of sperm to zona pellucida (GO:0007339) | 5.36876392 |
19 | microtubule polymerization or depolymerization (GO:0031109) | 5.31677834 |
20 | cell-cell recognition (GO:0009988) | 5.24267933 |
21 | sexual reproduction (GO:0019953) | 5.21661413 |
22 | protein targeting to Golgi (GO:0000042) | 4.98488649 |
23 | establishment of protein localization to Golgi (GO:0072600) | 4.91664400 |
24 | centriole replication (GO:0007099) | 4.90030183 |
25 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 4.88985568 |
26 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 4.88615352 |
27 | regulation of cilium movement (GO:0003352) | 4.84128426 |
28 | protein polyglutamylation (GO:0018095) | 4.75402875 |
29 | phosphatidylethanolamine metabolic process (GO:0046337) | 4.67731309 |
30 | rRNA modification (GO:0000154) | 4.64496095 |
31 | spermatogenesis (GO:0007283) | 4.56869990 |
32 | male gamete generation (GO:0048232) | 4.55829962 |
33 | microtubule severing (GO:0051013) | 4.37974610 |
34 | axonemal dynein complex assembly (GO:0070286) | 4.25563683 |
35 | RNA destabilization (GO:0050779) | 4.24687882 |
36 | regulation of T-helper 2 cell differentiation (GO:0045628) | 4.24425646 |
37 | chromatin silencing (GO:0006342) | 4.19266694 |
38 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.17538816 |
39 | gamete generation (GO:0007276) | 4.17472435 |
40 | single fertilization (GO:0007338) | 4.10286025 |
41 | regulation of inclusion body assembly (GO:0090083) | 4.04926114 |
42 | cellular ketone body metabolic process (GO:0046950) | 4.02218389 |
43 | positive regulation of Rab GTPase activity (GO:0032851) | 4.01338077 |
44 | regulation of Rab GTPase activity (GO:0032313) | 4.01338077 |
45 | centriole assembly (GO:0098534) | 3.92362987 |
46 | negative regulation of histone methylation (GO:0031061) | 3.88239726 |
47 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.87957360 |
48 | nucleus organization (GO:0006997) | 3.85203833 |
49 | thrombin receptor signaling pathway (GO:0070493) | 3.81848510 |
50 | regulation of centriole replication (GO:0046599) | 3.77735537 |
51 | motile cilium assembly (GO:0044458) | 3.69343003 |
52 | calcium ion-dependent exocytosis (GO:0017156) | 3.66118787 |
53 | regulation of histone H3-K9 methylation (GO:0051570) | 3.63684464 |
54 | regulation of integrin activation (GO:0033623) | 3.57733122 |
55 | polyamine biosynthetic process (GO:0006596) | 3.54436185 |
56 | ketone body metabolic process (GO:1902224) | 3.45657868 |
57 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 3.43180106 |
58 | germ cell development (GO:0007281) | 3.42260430 |
59 | protein neddylation (GO:0045116) | 3.39463054 |
60 | multicellular organismal reproductive process (GO:0048609) | 3.37396241 |
61 | positive regulation of endothelial cell differentiation (GO:0045603) | 3.34225127 |
62 | protein localization to Golgi apparatus (GO:0034067) | 3.31343263 |
63 | intra-Golgi vesicle-mediated transport (GO:0006891) | 3.30360651 |
64 | regulation of microtubule-based movement (GO:0060632) | 3.26903687 |
65 | fertilization (GO:0009566) | 3.24006940 |
66 | mitotic sister chromatid segregation (GO:0000070) | 3.23931012 |
67 | nucleosome disassembly (GO:0006337) | 3.20158555 |
68 | protein-DNA complex disassembly (GO:0032986) | 3.20158555 |
69 | regulation of interleukin-13 production (GO:0032656) | 3.18685494 |
70 | positive regulation of type 2 immune response (GO:0002830) | 3.10659187 |
71 | negative regulation of gene expression, epigenetic (GO:0045814) | 3.09965578 |
72 | cell wall macromolecule catabolic process (GO:0016998) | 3.07846983 |
73 | tyrosine metabolic process (GO:0006570) | 3.04864981 |
74 | microtubule nucleation (GO:0007020) | 3.00775835 |
75 | cell wall macromolecule metabolic process (GO:0044036) | 3.00466472 |
76 | regulation of platelet activation (GO:0010543) | 3.00241279 |
77 | DNA double-strand break processing (GO:0000729) | 2.94760682 |
78 | DNA conformation change (GO:0071103) | 2.91256069 |
79 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 2.85056852 |
80 | sister chromatid segregation (GO:0000819) | 2.79528472 |
81 | positive regulation of mast cell activation (GO:0033005) | 2.75457292 |
82 | regulation of platelet aggregation (GO:0090330) | 2.75219486 |
83 | termination of G-protein coupled receptor signaling pathway (GO:0038032) | 2.73030108 |
84 | termination of signal transduction (GO:0023021) | 2.72106849 |
85 | peptidyl-threonine dephosphorylation (GO:0035970) | 2.71763770 |
86 | adenosine receptor signaling pathway (GO:0001973) | 2.69406181 |
87 | histone H3-K9 methylation (GO:0051567) | 2.67425749 |
88 | leukocyte migration involved in inflammatory response (GO:0002523) | 2.65519186 |
89 | mast cell activation involved in immune response (GO:0002279) | 2.64436260 |
90 | mast cell degranulation (GO:0043303) | 2.64436260 |
91 | protein depolymerization (GO:0051261) | 2.62607918 |
92 | negative regulation of Rho protein signal transduction (GO:0035024) | 2.61727193 |
93 | neutrophil activation involved in immune response (GO:0002283) | 2.61351833 |
94 | homeostasis of number of cells within a tissue (GO:0048873) | 2.58812253 |
95 | B cell receptor signaling pathway (GO:0050853) | 2.58565823 |
96 | cellular biogenic amine biosynthetic process (GO:0042401) | 2.57208775 |
97 | seminiferous tubule development (GO:0072520) | 2.54659203 |
98 | receptor recycling (GO:0001881) | 2.53916821 |
99 | histone H3-K9 modification (GO:0061647) | 2.53805840 |
100 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.47123385 |
Rank | Gene Set | Z-score |
---|---|---|
1 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 3.45603621 |
2 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 3.14208944 |
3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.73318643 |
4 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.36234809 |
5 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 2.29114015 |
6 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.27669833 |
7 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.22999559 |
8 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.18517720 |
9 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.97678612 |
10 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.97486442 |
11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.84793193 |
12 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.84588566 |
13 | GATA1_19941826_ChIP-Seq_K562_Human | 1.83514683 |
14 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.77884961 |
15 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.77884961 |
16 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.75402407 |
17 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.72036010 |
18 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.71948768 |
19 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.71948768 |
20 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.69598970 |
21 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.67502922 |
22 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67362009 |
23 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.64519758 |
24 | SPI1_23127762_ChIP-Seq_K562_Human | 1.63846576 |
25 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.63142688 |
26 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.61903407 |
27 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.60029514 |
28 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.54580071 |
29 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.53843811 |
30 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.52322507 |
31 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.51913916 |
32 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.51828325 |
33 | GATA2_19941826_ChIP-Seq_K562_Human | 1.51666032 |
34 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.50691785 |
35 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.48391229 |
36 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.48317178 |
37 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.47766116 |
38 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.46955335 |
39 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.46008735 |
40 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.45463883 |
41 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.44495517 |
42 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.43096870 |
43 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.42471907 |
44 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.40406926 |
45 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.39341113 |
46 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.38446391 |
47 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.35812623 |
48 | P300_27268052_Chip-Seq_Bcells_Human | 1.34287094 |
49 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.34004028 |
50 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.33260688 |
51 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.33076776 |
52 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.32682055 |
53 | ERA_21632823_ChIP-Seq_H3396_Human | 1.32024268 |
54 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.32005320 |
55 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.31148527 |
56 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.30616099 |
57 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.30327593 |
58 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.29027655 |
59 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27292949 |
60 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.27135840 |
61 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.26898344 |
62 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.26684732 |
63 | MYB_26560356_Chip-Seq_TH2_Human | 1.26473059 |
64 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.25867043 |
65 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.24676876 |
66 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.24301908 |
67 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.23086861 |
68 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.22080173 |
69 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.21290786 |
70 | NFYB_21822215_ChIP-Seq_K562_Human | 1.20153157 |
71 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 1.19853832 |
72 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.18540640 |
73 | TBL1_22424771_ChIP-Seq_293T_Human | 1.18432721 |
74 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.17399086 |
75 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.16423999 |
76 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.15983748 |
77 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.15343993 |
78 | GATA3_26560356_Chip-Seq_TH1_Human | 1.15176788 |
79 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.14471670 |
80 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.14256097 |
81 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.13028825 |
82 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.11790878 |
83 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.11234361 |
84 | FUS_26573619_Chip-Seq_HEK293_Human | 1.09283164 |
85 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.08037461 |
86 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.07976266 |
87 | GATA3_26560356_Chip-Seq_TH2_Human | 1.07318138 |
88 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.06647069 |
89 | * TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.06147682 |
90 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.05640399 |
91 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.05623479 |
92 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.05297261 |
93 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.05181694 |
94 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.04839169 |
95 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.03521148 |
96 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.03280169 |
97 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.03190945 |
98 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.02940794 |
99 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.02646636 |
100 | P68_20966046_ChIP-Seq_HELA_Human | 1.02521263 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005464_abnormal_platelet_physiology | 4.34249764 |
2 | MP0003698_abnormal_male_reproductive | 3.65219543 |
3 | MP0005670_abnormal_white_adipose | 3.52361277 |
4 | MP0001929_abnormal_gametogenesis | 3.31853969 |
5 | MP0002132_abnormal_respiratory_system | 2.53091970 |
6 | MP0008057_abnormal_DNA_replication | 2.37829045 |
7 | MP0005377_hearing/vestibular/ear_phenot | 2.31338381 |
8 | MP0003878_abnormal_ear_physiology | 2.31338381 |
9 | MP0008004_abnormal_stomach_pH | 2.18197499 |
10 | MP0008877_abnormal_DNA_methylation | 2.06763748 |
11 | MP0001348_abnormal_lacrimal_gland | 2.02693869 |
12 | MP0005410_abnormal_fertilization | 10.0977760 |
13 | MP0001835_abnormal_antigen_presentation | 1.98189598 |
14 | MP0002161_abnormal_fertility/fecundity | 1.89327083 |
15 | MP0003724_increased_susceptibility_to | 1.79061200 |
16 | MP0009697_abnormal_copulation | 1.72191651 |
17 | MP0003693_abnormal_embryo_hatching | 1.65891724 |
18 | MP0005083_abnormal_biliary_tract | 1.58253674 |
19 | MP0002210_abnormal_sex_determination | 1.57564984 |
20 | MP0001800_abnormal_humoral_immune | 1.53463969 |
21 | MP0003646_muscle_fatigue | 1.43218955 |
22 | MP0003718_maternal_effect | 1.42756753 |
23 | MP0004510_myositis | 1.40724909 |
24 | MP0010094_abnormal_chromosome_stability | 1.39883784 |
25 | MP0008007_abnormal_cellular_replicative | 1.35839151 |
26 | MP0003077_abnormal_cell_cycle | 1.32747697 |
27 | MP0001145_abnormal_male_reproductive | 1.29972491 |
28 | MP0000678_abnormal_parathyroid_gland | 1.29483900 |
29 | MP0001968_abnormal_touch/_nociception | 1.26742656 |
30 | MP0002398_abnormal_bone_marrow | 1.26712210 |
31 | MP0001879_abnormal_lymphatic_vessel | 1.25667295 |
32 | MP0000653_abnormal_sex_gland | 1.25052831 |
33 | MP0000685_abnormal_immune_system | 1.23203825 |
34 | MP0002452_abnormal_antigen_presenting | 1.21264296 |
35 | MP0002723_abnormal_immune_serum | 1.21162074 |
36 | MP0005000_abnormal_immune_tolerance | 1.20134624 |
37 | MP0004808_abnormal_hematopoietic_stem | 1.17932407 |
38 | MP0003303_peritoneal_inflammation | 1.15103195 |
39 | MP0002735_abnormal_chemical_nociception | 1.14314077 |
40 | MP0002138_abnormal_hepatobiliary_system | 1.12953577 |
41 | MP0005167_abnormal_blood-brain_barrier | 1.07998822 |
42 | MP0000015_abnormal_ear_pigmentation | 1.05643920 |
43 | MP0004036_abnormal_muscle_relaxation | 1.04202069 |
44 | MP0004084_abnormal_cardiac_muscle | 0.98520762 |
45 | MP0000689_abnormal_spleen_morphology | 0.98226359 |
46 | MP0001790_abnormal_immune_system | 0.97396024 |
47 | MP0005387_immune_system_phenotype | 0.97396024 |
48 | MP0005310_abnormal_salivary_gland | 0.97168950 |
49 | MP0002722_abnormal_immune_system | 0.96519454 |
50 | MP0005423_abnormal_somatic_nervous | 0.93256502 |
51 | MP0008569_lethality_at_weaning | 0.92986955 |
52 | MP0003172_abnormal_lysosome_physiology | 0.92974506 |
53 | MP0004947_skin_inflammation | 0.92775940 |
54 | MP0001765_abnormal_ion_homeostasis | 0.92757809 |
55 | MP0002420_abnormal_adaptive_immunity | 0.91791049 |
56 | MP0009115_abnormal_fat_cell | 0.91440545 |
57 | MP0000249_abnormal_blood_vessel | 0.89818372 |
58 | MP0004130_abnormal_muscle_cell | 0.88395206 |
59 | MP0000716_abnormal_immune_system | 0.87647207 |
60 | MP0010307_abnormal_tumor_latency | 0.86857557 |
61 | MP0002429_abnormal_blood_cell | 0.86839181 |
62 | MP0001819_abnormal_immune_cell | 0.86819933 |
63 | MP0003763_abnormal_thymus_physiology | 0.85831188 |
64 | MP0009053_abnormal_anal_canal | 0.84229367 |
65 | MP0003879_abnormal_hair_cell | 0.82802120 |
66 | MP0003011_delayed_dark_adaptation | 0.82606778 |
67 | MP0000465_gastrointestinal_hemorrhage | 0.82007094 |
68 | MP0005666_abnormal_adipose_tissue | 0.81715070 |
69 | MP0000343_altered_response_to | 0.81368310 |
70 | MP0002127_abnormal_cardiovascular_syste | 0.78809916 |
71 | MP0002733_abnormal_thermal_nociception | 0.77922060 |
72 | MP0005397_hematopoietic_system_phenotyp | 0.77644936 |
73 | MP0001545_abnormal_hematopoietic_system | 0.77644936 |
74 | MP0000703_abnormal_thymus_morphology | 0.77340548 |
75 | MP0005084_abnormal_gallbladder_morpholo | 0.76813244 |
76 | MP0008995_early_reproductive_senescence | 0.76259409 |
77 | MP0003436_decreased_susceptibility_to | 0.75917443 |
78 | MP0000230_abnormal_systemic_arterial | 0.75055636 |
79 | MP0003111_abnormal_nucleus_morphology | 0.73549086 |
80 | MP0009764_decreased_sensitivity_to | 0.73488465 |
81 | MP0005551_abnormal_eye_electrophysiolog | 0.73040164 |
82 | MP0005535_abnormal_body_temperature | 0.70652081 |
83 | MP0000313_abnormal_cell_death | 0.69739797 |
84 | MP0002148_abnormal_hypersensitivity_rea | 0.65580537 |
85 | MP0005253_abnormal_eye_physiology | 0.65368972 |
86 | MP0000534_abnormal_ureter_morphology | 0.64608061 |
87 | MP0004742_abnormal_vestibular_system | 0.64567331 |
88 | MP0002332_abnormal_exercise_endurance | 0.64422543 |
89 | MP0009333_abnormal_splenocyte_physiolog | 0.64102615 |
90 | MP0005395_other_phenotype | 0.62794236 |
91 | MP0004134_abnormal_chest_morphology | 0.61147264 |
92 | MP0001986_abnormal_taste_sensitivity | 0.60280669 |
93 | MP0005025_abnormal_response_to | 0.60097159 |
94 | MP0010386_abnormal_urinary_bladder | 0.57232625 |
95 | MP0003045_fibrosis | 0.57027309 |
96 | MP0002282_abnormal_trachea_morphology | 0.55631619 |
97 | MP0001970_abnormal_pain_threshold | 0.55609002 |
98 | MP0003638_abnormal_response/metabolism_ | 0.54035261 |
99 | MP0001533_abnormal_skeleton_physiology | 0.53767269 |
100 | MP0002736_abnormal_nociception_after | 0.53655547 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Prolonged bleeding time (HP:0003010) | 5.85646011 |
2 | Severe visual impairment (HP:0001141) | 5.07364505 |
3 | Absent/shortened dynein arms (HP:0200106) | 4.58392579 |
4 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.58392579 |
5 | Increased mean platelet volume (HP:0011877) | 4.40345925 |
6 | Menorrhagia (HP:0000132) | 4.37545211 |
7 | Abnormal platelet volume (HP:0011876) | 4.21258649 |
8 | Chronic hepatic failure (HP:0100626) | 4.14648082 |
9 | Hyperkalemia (HP:0002153) | 3.99599836 |
10 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.98356885 |
11 | Male infertility (HP:0003251) | 3.93753911 |
12 | Attenuation of retinal blood vessels (HP:0007843) | 3.91010311 |
13 | Abnormal ciliary motility (HP:0012262) | 3.90079466 |
14 | Tubulointerstitial nephritis (HP:0001970) | 3.88455106 |
15 | Petechiae (HP:0000967) | 3.87437116 |
16 | Epistaxis (HP:0000421) | 3.77297381 |
17 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.67685355 |
18 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.67685355 |
19 | Bony spicule pigmentary retinopathy (HP:0007737) | 3.62439136 |
20 | Infertility (HP:0000789) | 3.48795824 |
21 | Purpura (HP:0000979) | 3.33923482 |
22 | Abnormal spermatogenesis (HP:0008669) | 3.33492371 |
23 | Nasal polyposis (HP:0100582) | 3.33230475 |
24 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.30158597 |
25 | Hyperlipoproteinemia (HP:0010980) | 3.12968845 |
26 | Gingival bleeding (HP:0000225) | 3.06875846 |
27 | Acute hepatic failure (HP:0006554) | 2.91927921 |
28 | Impaired platelet aggregation (HP:0003540) | 2.77682266 |
29 | Abnormal platelet function (HP:0011869) | 2.77682266 |
30 | Cone-rod dystrophy (HP:0000548) | 2.77311978 |
31 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.75522104 |
32 | Azoospermia (HP:0000027) | 2.75366319 |
33 | Spontaneous hematomas (HP:0007420) | 2.74339038 |
34 | Upper limb muscle weakness (HP:0003484) | 2.70043075 |
35 | Poikilocytosis (HP:0004447) | 2.65390823 |
36 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.57100896 |
37 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.57100896 |
38 | Truncal obesity (HP:0001956) | 2.51382483 |
39 | Resting tremor (HP:0002322) | 2.50588087 |
40 | Abnormality of the nasal mucosa (HP:0000433) | 2.49525139 |
41 | Hypophosphatemic rickets (HP:0004912) | 2.49367404 |
42 | Progressive cerebellar ataxia (HP:0002073) | 2.49080284 |
43 | Impulsivity (HP:0100710) | 2.47929017 |
44 | Progressive sensorineural hearing impairment (HP:0000408) | 2.47556572 |
45 | Paralysis (HP:0003470) | 2.46083995 |
46 | Papilledema (HP:0001085) | 2.45493443 |
47 | Abnormality of macular pigmentation (HP:0008002) | 2.37428456 |
48 | Cerebellar dysplasia (HP:0007033) | 2.31567302 |
49 | Menstrual irregularities (HP:0000858) | 2.27296604 |
50 | Horizontal nystagmus (HP:0000666) | 2.24615838 |
51 | Termporal pattern (HP:0011008) | 2.23695127 |
52 | Insidious onset (HP:0003587) | 2.23695127 |
53 | Pendular nystagmus (HP:0012043) | 2.18682466 |
54 | Abnormality of lateral ventricle (HP:0030047) | 2.16270440 |
55 | Spontaneous abortion (HP:0005268) | 2.15852575 |
56 | Postural instability (HP:0002172) | 2.12789493 |
57 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 2.07398802 |
58 | Tinnitus (HP:0000360) | 2.05969743 |
59 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.02443133 |
60 | Acanthocytosis (HP:0001927) | 2.01716191 |
61 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.99923805 |
62 | Dyschromatopsia (HP:0007641) | 1.99459810 |
63 | Potter facies (HP:0002009) | 1.98583275 |
64 | Facial shape deformation (HP:0011334) | 1.98583275 |
65 | Portal hypertension (HP:0001409) | 1.96023747 |
66 | Hypoalphalipoproteinemia (HP:0003233) | 1.95430629 |
67 | Bronchiectasis (HP:0002110) | 1.95341807 |
68 | Decreased central vision (HP:0007663) | 1.91339123 |
69 | Prominent nose (HP:0000448) | 1.90504553 |
70 | Recurrent pneumonia (HP:0006532) | 1.89364414 |
71 | Abnormality of the hepatic vasculature (HP:0006707) | 1.86837423 |
72 | Easy fatigability (HP:0003388) | 1.85960238 |
73 | Colitis (HP:0002583) | 1.84676641 |
74 | Retinal dysplasia (HP:0007973) | 1.82893695 |
75 | Ectopic kidney (HP:0000086) | 1.81607889 |
76 | Recurrent sinusitis (HP:0011108) | 1.81000155 |
77 | Asymmetric septal hypertrophy (HP:0001670) | 1.78787442 |
78 | Cystic hygroma (HP:0000476) | 1.78677808 |
79 | Submucous cleft hard palate (HP:0000176) | 1.78664699 |
80 | Rhinitis (HP:0012384) | 1.78065661 |
81 | Abnormality of potassium homeostasis (HP:0011042) | 1.77359944 |
82 | Inflammation of the large intestine (HP:0002037) | 1.77118696 |
83 | Hypoplastic ischia (HP:0003175) | 1.76895579 |
84 | Increased density of long bones (HP:0006392) | 1.76692578 |
85 | Abnormal pupillary function (HP:0007686) | 1.75384852 |
86 | Abnormality of the prostate (HP:0008775) | 1.74244958 |
87 | Type II lissencephaly (HP:0007260) | 1.73801111 |
88 | Bruising susceptibility (HP:0000978) | 1.73321191 |
89 | Gastrointestinal inflammation (HP:0004386) | 1.71894245 |
90 | Failure to thrive in infancy (HP:0001531) | 1.70750487 |
91 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.70287392 |
92 | Progressive hearing impairment (HP:0001730) | 1.69747012 |
93 | Intellectual disability, profound (HP:0002187) | 1.68246613 |
94 | Nonprogressive disorder (HP:0003680) | 1.67261935 |
95 | Abnormality of the fingertips (HP:0001211) | 1.64545752 |
96 | Enlarged epiphyses (HP:0010580) | 1.64287062 |
97 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.64196379 |
98 | Hypoplasia of the thymus (HP:0000778) | 1.62339929 |
99 | Bell-shaped thorax (HP:0001591) | 1.62232659 |
100 | Chronic sinusitis (HP:0011109) | 1.62136287 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PLK4 | 6.48444054 |
2 | MUSK | 3.95212622 |
3 | RIPK4 | 3.15205547 |
4 | PNCK | 3.08489077 |
5 | TESK1 | 2.97459912 |
6 | STK38 | 2.69533896 |
7 | CDK12 | 2.62620178 |
8 | PIK3CG | 2.55146657 |
9 | MAP4K2 | 2.14840682 |
10 | BRSK2 | 2.09774278 |
11 | TRIM28 | 1.98967369 |
12 | AKT3 | 1.91200737 |
13 | IRAK1 | 1.90297411 |
14 | MST4 | 1.83378346 |
15 | CAMK1G | 1.81930569 |
16 | PLK2 | 1.81538319 |
17 | BRD4 | 1.79799340 |
18 | PDK1 | 1.76958014 |
19 | BTK | 1.65764463 |
20 | TEC | 1.60010031 |
21 | MARK3 | 1.59106188 |
22 | PTK2B | 1.57877905 |
23 | DDR2 | 1.56795084 |
24 | PDPK1 | 1.49705410 |
25 | MAP3K10 | 1.45939188 |
26 | PDK2 | 1.44411384 |
27 | SYK | 1.43874936 |
28 | MAPK15 | 1.41934897 |
29 | NEK6 | 1.38630079 |
30 | SIK2 | 1.35360851 |
31 | SIK3 | 1.33952109 |
32 | BMPR1B | 1.25354622 |
33 | TESK2 | 1.10215023 |
34 | STK38L | 1.05423940 |
35 | MAP3K2 | 1.03705015 |
36 | CSF1R | 1.00826398 |
37 | BMX | 1.00079335 |
38 | EIF2AK3 | 0.99168339 |
39 | INSRR | 0.97241025 |
40 | GRK6 | 0.92574784 |
41 | FRK | 0.92527196 |
42 | MYLK | 0.91223561 |
43 | CDK7 | 0.88345315 |
44 | BLK | 0.87541712 |
45 | HCK | 0.87267142 |
46 | IKBKB | 0.86922304 |
47 | PKN1 | 0.86653168 |
48 | MAP4K1 | 0.83849407 |
49 | WNK1 | 0.79068082 |
50 | MAPK7 | 0.78695592 |
51 | KSR2 | 0.73570672 |
52 | MAPKAPK5 | 0.72031540 |
53 | TAOK3 | 0.71740695 |
54 | PAK1 | 0.70181908 |
55 | LYN | 0.68795822 |
56 | LMTK2 | 0.67574854 |
57 | BRAF | 0.66702324 |
58 | MAP3K3 | 0.63996004 |
59 | MAP3K13 | 0.63494484 |
60 | CDK3 | 0.63449994 |
61 | PRKG1 | 0.63385378 |
62 | TNK2 | 0.59924642 |
63 | STK3 | 0.58188419 |
64 | FER | 0.58136962 |
65 | MAPK11 | 0.55762455 |
66 | IRAK4 | 0.54100554 |
67 | DYRK3 | 0.51536080 |
68 | NEK2 | 0.51532267 |
69 | CDK9 | 0.51402312 |
70 | CAMK1D | 0.47017083 |
71 | BRSK1 | 0.46768299 |
72 | SGK2 | 0.44951217 |
73 | CDK4 | 0.43674546 |
74 | MAPK1 | 0.43179343 |
75 | EPHB1 | 0.42027902 |
76 | ITK | 0.41646137 |
77 | DYRK1B | 0.41485255 |
78 | BMPR2 | 0.39342170 |
79 | ZAP70 | 0.39114139 |
80 | MAP3K4 | 0.37855208 |
81 | ACVR1B | 0.34919888 |
82 | PRKCQ | 0.34722406 |
83 | MAPK12 | 0.34711940 |
84 | CDK2 | 0.32510209 |
85 | PRKCB | 0.31605099 |
86 | EIF2AK1 | 0.31582234 |
87 | CDK1 | 0.31575521 |
88 | EEF2K | 0.30193385 |
89 | PRKAA2 | 0.29886916 |
90 | CHEK1 | 0.29382061 |
91 | ROCK1 | 0.28549674 |
92 | ATR | 0.28148410 |
93 | CCNB1 | 0.27917625 |
94 | PRKD1 | 0.27708326 |
95 | RPS6KA1 | 0.27334720 |
96 | MAPK14 | 0.27285991 |
97 | GSK3B | 0.27262134 |
98 | CHUK | 0.27210041 |
99 | PRKAA1 | 0.26884601 |
100 | STK4 | 0.24336578 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 3.91713955 |
2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.68002002 |
3 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 3.14040620 |
4 | Platelet activation_Homo sapiens_hsa04611 | 2.84309335 |
5 | Olfactory transduction_Homo sapiens_hsa04740 | 2.39645294 |
6 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.34114539 |
7 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.95932213 |
8 | Alcoholism_Homo sapiens_hsa05034 | 1.88631822 |
9 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.75997521 |
10 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.61742370 |
11 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.59490313 |
12 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.57287598 |
13 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.57049312 |
14 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.42015959 |
15 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.40967058 |
16 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.37606231 |
17 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.35138232 |
18 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.30812550 |
19 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.30738090 |
20 | Morphine addiction_Homo sapiens_hsa05032 | 1.27013439 |
21 | Influenza A_Homo sapiens_hsa05164 | 1.25493526 |
22 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.24891130 |
23 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.23857590 |
24 | Taste transduction_Homo sapiens_hsa04742 | 1.17076591 |
25 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.16981054 |
26 | Allograft rejection_Homo sapiens_hsa05330 | 1.16139078 |
27 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.14178105 |
28 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.11899547 |
29 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.09624270 |
30 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.05469112 |
31 | Endocytosis_Homo sapiens_hsa04144 | 1.04563897 |
32 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.04244174 |
33 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.01479120 |
34 | Gap junction_Homo sapiens_hsa04540 | 1.00765746 |
35 | Phototransduction_Homo sapiens_hsa04744 | 1.00614561 |
36 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.95810101 |
37 | Measles_Homo sapiens_hsa05162 | 0.94065653 |
38 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.93338752 |
39 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.92465625 |
40 | Circadian entrainment_Homo sapiens_hsa04713 | 0.90407824 |
41 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.90390374 |
42 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.89042924 |
43 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.88768785 |
44 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.82747209 |
45 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.78616491 |
46 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.78402897 |
47 | Long-term depression_Homo sapiens_hsa04730 | 0.78111873 |
48 | RNA transport_Homo sapiens_hsa03013 | 0.75468334 |
49 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.75234690 |
50 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.75225902 |
51 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.74759102 |
52 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.74630582 |
53 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.74624635 |
54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.74510105 |
55 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.74055228 |
56 | Basal transcription factors_Homo sapiens_hsa03022 | 0.73916662 |
57 | Viral myocarditis_Homo sapiens_hsa05416 | 0.73409959 |
58 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.72007276 |
59 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.70518983 |
60 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.70501310 |
61 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.67261135 |
62 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.66364649 |
63 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.65755450 |
64 | Cell cycle_Homo sapiens_hsa04110 | 0.65712627 |
65 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.65035225 |
66 | Legionellosis_Homo sapiens_hsa05134 | 0.64320543 |
67 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.63967124 |
68 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.63940916 |
69 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.62110000 |
70 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61775427 |
71 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.57922135 |
72 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57693258 |
73 | Lysine degradation_Homo sapiens_hsa00310 | 0.57678744 |
74 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.57207412 |
75 | GABAergic synapse_Homo sapiens_hsa04727 | 0.56582539 |
76 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.56579127 |
77 | Prostate cancer_Homo sapiens_hsa05215 | 0.56557031 |
78 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.55960044 |
79 | ABC transporters_Homo sapiens_hsa02010 | 0.53356647 |
80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53085338 |
81 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.52701317 |
82 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.52337623 |
83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.51818778 |
84 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.51285233 |
85 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.50286355 |
86 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.50050639 |
87 | Hepatitis B_Homo sapiens_hsa05161 | 0.48716214 |
88 | Endometrial cancer_Homo sapiens_hsa05213 | 0.48050783 |
89 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.47946750 |
90 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.45366680 |
91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.45355140 |
92 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.44384961 |
93 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.43785609 |
94 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.42184973 |
95 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.41952466 |
96 | Apoptosis_Homo sapiens_hsa04210 | 0.41558771 |
97 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.41522819 |
98 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.40021884 |
99 | Glioma_Homo sapiens_hsa05214 | 0.39913976 |
100 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.39311254 |