C3ORF20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.08621175
2fusion of sperm to egg plasma membrane (GO:0007342)8.22027015
3acrosome reaction (GO:0007340)8.06050058
4spermatid nucleus differentiation (GO:0007289)7.94743465
5single strand break repair (GO:0000012)7.61876111
6microtubule depolymerization (GO:0007019)7.32111835
7chromosome condensation (GO:0030261)7.17603925
8DNA packaging (GO:0006323)7.11389234
9multicellular organism reproduction (GO:0032504)6.80500273
10sperm capacitation (GO:0048240)6.66327017
11response to pheromone (GO:0019236)6.43792719
12sperm-egg recognition (GO:0035036)6.22745080
13reproduction (GO:0000003)6.12267222
14plasma membrane fusion (GO:0045026)6.04223202
15negative regulation of inclusion body assembly (GO:0090084)5.80687118
16spermatid development (GO:0007286)5.80187528
17rRNA methylation (GO:0031167)5.67717440
18binding of sperm to zona pellucida (GO:0007339)5.36876392
19microtubule polymerization or depolymerization (GO:0031109)5.31677834
20cell-cell recognition (GO:0009988)5.24267933
21sexual reproduction (GO:0019953)5.21661413
22protein targeting to Golgi (GO:0000042)4.98488649
23establishment of protein localization to Golgi (GO:0072600)4.91664400
24centriole replication (GO:0007099)4.90030183
25retrograde transport, vesicle recycling within Golgi (GO:0000301)4.88985568
26phosphatidylethanolamine biosynthetic process (GO:0006646)4.88615352
27regulation of cilium movement (GO:0003352)4.84128426
28protein polyglutamylation (GO:0018095)4.75402875
29phosphatidylethanolamine metabolic process (GO:0046337)4.67731309
30rRNA modification (GO:0000154)4.64496095
31spermatogenesis (GO:0007283)4.56869990
32male gamete generation (GO:0048232)4.55829962
33microtubule severing (GO:0051013)4.37974610
34axonemal dynein complex assembly (GO:0070286)4.25563683
35RNA destabilization (GO:0050779)4.24687882
36regulation of T-helper 2 cell differentiation (GO:0045628)4.24425646
37chromatin silencing (GO:0006342)4.19266694
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17538816
39gamete generation (GO:0007276)4.17472435
40single fertilization (GO:0007338)4.10286025
41regulation of inclusion body assembly (GO:0090083)4.04926114
42cellular ketone body metabolic process (GO:0046950)4.02218389
43positive regulation of Rab GTPase activity (GO:0032851)4.01338077
44regulation of Rab GTPase activity (GO:0032313)4.01338077
45centriole assembly (GO:0098534)3.92362987
46negative regulation of histone methylation (GO:0031061)3.88239726
47cilium or flagellum-dependent cell motility (GO:0001539)3.87957360
48nucleus organization (GO:0006997)3.85203833
49thrombin receptor signaling pathway (GO:0070493)3.81848510
50regulation of centriole replication (GO:0046599)3.77735537
51motile cilium assembly (GO:0044458)3.69343003
52calcium ion-dependent exocytosis (GO:0017156)3.66118787
53regulation of histone H3-K9 methylation (GO:0051570)3.63684464
54regulation of integrin activation (GO:0033623)3.57733122
55polyamine biosynthetic process (GO:0006596)3.54436185
56ketone body metabolic process (GO:1902224)3.45657868
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.43180106
58germ cell development (GO:0007281)3.42260430
59protein neddylation (GO:0045116)3.39463054
60multicellular organismal reproductive process (GO:0048609)3.37396241
61positive regulation of endothelial cell differentiation (GO:0045603)3.34225127
62protein localization to Golgi apparatus (GO:0034067)3.31343263
63intra-Golgi vesicle-mediated transport (GO:0006891)3.30360651
64regulation of microtubule-based movement (GO:0060632)3.26903687
65fertilization (GO:0009566)3.24006940
66mitotic sister chromatid segregation (GO:0000070)3.23931012
67nucleosome disassembly (GO:0006337)3.20158555
68protein-DNA complex disassembly (GO:0032986)3.20158555
69regulation of interleukin-13 production (GO:0032656)3.18685494
70positive regulation of type 2 immune response (GO:0002830)3.10659187
71negative regulation of gene expression, epigenetic (GO:0045814)3.09965578
72cell wall macromolecule catabolic process (GO:0016998)3.07846983
73tyrosine metabolic process (GO:0006570)3.04864981
74microtubule nucleation (GO:0007020)3.00775835
75cell wall macromolecule metabolic process (GO:0044036)3.00466472
76regulation of platelet activation (GO:0010543)3.00241279
77DNA double-strand break processing (GO:0000729)2.94760682
78DNA conformation change (GO:0071103)2.91256069
79purinergic nucleotide receptor signaling pathway (GO:0035590)2.85056852
80sister chromatid segregation (GO:0000819)2.79528472
81positive regulation of mast cell activation (GO:0033005)2.75457292
82regulation of platelet aggregation (GO:0090330)2.75219486
83termination of G-protein coupled receptor signaling pathway (GO:0038032)2.73030108
84termination of signal transduction (GO:0023021)2.72106849
85peptidyl-threonine dephosphorylation (GO:0035970)2.71763770
86adenosine receptor signaling pathway (GO:0001973)2.69406181
87histone H3-K9 methylation (GO:0051567)2.67425749
88leukocyte migration involved in inflammatory response (GO:0002523)2.65519186
89mast cell activation involved in immune response (GO:0002279)2.64436260
90mast cell degranulation (GO:0043303)2.64436260
91protein depolymerization (GO:0051261)2.62607918
92negative regulation of Rho protein signal transduction (GO:0035024)2.61727193
93neutrophil activation involved in immune response (GO:0002283)2.61351833
94homeostasis of number of cells within a tissue (GO:0048873)2.58812253
95B cell receptor signaling pathway (GO:0050853)2.58565823
96cellular biogenic amine biosynthetic process (GO:0042401)2.57208775
97seminiferous tubule development (GO:0072520)2.54659203
98receptor recycling (GO:0001881)2.53916821
99histone H3-K9 modification (GO:0061647)2.53805840
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.47123385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.45603621
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.14208944
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73318643
4SCL_19346495_ChIP-Seq_HPC-7_Human2.36234809
5* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.29114015
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27669833
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22999559
8EZH2_22144423_ChIP-Seq_EOC_Human2.18517720
9ER_23166858_ChIP-Seq_MCF-7_Human1.97678612
10IRF8_22096565_ChIP-ChIP_GC-B_Human1.97486442
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84793193
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.84588566
13GATA1_19941826_ChIP-Seq_K562_Human1.83514683
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77884961
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77884961
16RUNX_20019798_ChIP-Seq_JUKART_Human1.75402407
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72036010
18CBP_20019798_ChIP-Seq_JUKART_Human1.71948768
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71948768
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69598970
21SMRT_27268052_Chip-Seq_Bcells_Human1.67502922
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67362009
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64519758
24SPI1_23127762_ChIP-Seq_K562_Human1.63846576
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63142688
26PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.61903407
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.60029514
28SALL4_22934838_ChIP-ChIP_CD34+_Human1.54580071
29EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.53843811
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.52322507
31KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.51913916
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51828325
33GATA2_19941826_ChIP-Seq_K562_Human1.51666032
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50691785
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48391229
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48317178
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47766116
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46955335
39BCOR_27268052_Chip-Seq_Bcells_Human1.46008735
40NANOG_20526341_ChIP-Seq_ESCs_Human1.45463883
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44495517
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43096870
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.42471907
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40406926
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.39341113
46BCL6_27268052_Chip-Seq_Bcells_Human1.38446391
47RAC3_21632823_ChIP-Seq_H3396_Human1.35812623
48P300_27268052_Chip-Seq_Bcells_Human1.34287094
49* STAT3_23295773_ChIP-Seq_U87_Human1.34004028
50CEBPB_22108803_ChIP-Seq_LS180_Human1.33260688
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33076776
52TAF15_26573619_Chip-Seq_HEK293_Human1.32682055
53ERA_21632823_ChIP-Seq_H3396_Human1.32024268
54AR_21572438_ChIP-Seq_LNCaP_Human1.32005320
55RBPJ_21746931_ChIP-Seq_IB4_Human1.31148527
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.30616099
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30327593
58TAF2_19829295_ChIP-Seq_ESCs_Human1.29027655
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27292949
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27135840
61ERG_20517297_ChIP-Seq_VCAP_Human1.26898344
62* AR_25329375_ChIP-Seq_VCAP_Human1.26684732
63MYB_26560356_Chip-Seq_TH2_Human1.26473059
64GATA1_19941827_ChIP-Seq_MEL86_Mouse1.25867043
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.24676876
66HNFA_21074721_ChIP-Seq_CACO-2_Human1.24301908
67OCT4_20526341_ChIP-Seq_ESCs_Human1.23086861
68DROSHA_22980978_ChIP-Seq_HELA_Human1.22080173
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.21290786
70NFYB_21822215_ChIP-Seq_K562_Human1.20153157
71OCT1_27270436_Chip-Seq_PROSTATE_Human1.19853832
72ETV1_20927104_ChIP-Seq_GIST48_Human1.18540640
73TBL1_22424771_ChIP-Seq_293T_Human1.18432721
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17399086
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16423999
76CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15983748
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15343993
78GATA3_26560356_Chip-Seq_TH1_Human1.15176788
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14471670
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14256097
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13028825
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11790878
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.11234361
84FUS_26573619_Chip-Seq_HEK293_Human1.09283164
85VDR_24787735_ChIP-Seq_THP-1_Human1.08037461
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07976266
87GATA3_26560356_Chip-Seq_TH2_Human1.07318138
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06647069
89* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06147682
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05640399
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.05623479
92SPI1_20517297_ChIP-Seq_HL60_Human1.05297261
93E2F1_20622854_ChIP-Seq_HELA_Human1.05181694
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04839169
95PHF8_20622853_ChIP-Seq_HELA_Human1.03521148
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03280169
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03190945
98PHF8_20622854_ChIP-Seq_HELA_Human1.02940794
99FOXM1_23109430_ChIP-Seq_U2OS_Human1.02646636
100P68_20966046_ChIP-Seq_HELA_Human1.02521263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.34249764
2MP0003698_abnormal_male_reproductive3.65219543
3MP0005670_abnormal_white_adipose3.52361277
4MP0001929_abnormal_gametogenesis3.31853969
5MP0002132_abnormal_respiratory_system2.53091970
6MP0008057_abnormal_DNA_replication2.37829045
7MP0005377_hearing/vestibular/ear_phenot2.31338381
8MP0003878_abnormal_ear_physiology2.31338381
9MP0008004_abnormal_stomach_pH2.18197499
10MP0008877_abnormal_DNA_methylation2.06763748
11MP0001348_abnormal_lacrimal_gland2.02693869
12MP0005410_abnormal_fertilization10.0977760
13MP0001835_abnormal_antigen_presentation1.98189598
14MP0002161_abnormal_fertility/fecundity1.89327083
15MP0003724_increased_susceptibility_to1.79061200
16MP0009697_abnormal_copulation1.72191651
17MP0003693_abnormal_embryo_hatching1.65891724
18MP0005083_abnormal_biliary_tract1.58253674
19MP0002210_abnormal_sex_determination1.57564984
20MP0001800_abnormal_humoral_immune1.53463969
21MP0003646_muscle_fatigue1.43218955
22MP0003718_maternal_effect1.42756753
23MP0004510_myositis1.40724909
24MP0010094_abnormal_chromosome_stability1.39883784
25MP0008007_abnormal_cellular_replicative1.35839151
26MP0003077_abnormal_cell_cycle1.32747697
27MP0001145_abnormal_male_reproductive1.29972491
28MP0000678_abnormal_parathyroid_gland1.29483900
29MP0001968_abnormal_touch/_nociception1.26742656
30MP0002398_abnormal_bone_marrow1.26712210
31MP0001879_abnormal_lymphatic_vessel1.25667295
32MP0000653_abnormal_sex_gland1.25052831
33MP0000685_abnormal_immune_system1.23203825
34MP0002452_abnormal_antigen_presenting1.21264296
35MP0002723_abnormal_immune_serum1.21162074
36MP0005000_abnormal_immune_tolerance1.20134624
37MP0004808_abnormal_hematopoietic_stem1.17932407
38MP0003303_peritoneal_inflammation1.15103195
39MP0002735_abnormal_chemical_nociception1.14314077
40MP0002138_abnormal_hepatobiliary_system1.12953577
41MP0005167_abnormal_blood-brain_barrier1.07998822
42MP0000015_abnormal_ear_pigmentation1.05643920
43MP0004036_abnormal_muscle_relaxation1.04202069
44MP0004084_abnormal_cardiac_muscle0.98520762
45MP0000689_abnormal_spleen_morphology0.98226359
46MP0001790_abnormal_immune_system0.97396024
47MP0005387_immune_system_phenotype0.97396024
48MP0005310_abnormal_salivary_gland0.97168950
49MP0002722_abnormal_immune_system0.96519454
50MP0005423_abnormal_somatic_nervous0.93256502
51MP0008569_lethality_at_weaning0.92986955
52MP0003172_abnormal_lysosome_physiology0.92974506
53MP0004947_skin_inflammation0.92775940
54MP0001765_abnormal_ion_homeostasis0.92757809
55MP0002420_abnormal_adaptive_immunity0.91791049
56MP0009115_abnormal_fat_cell0.91440545
57MP0000249_abnormal_blood_vessel0.89818372
58MP0004130_abnormal_muscle_cell0.88395206
59MP0000716_abnormal_immune_system0.87647207
60MP0010307_abnormal_tumor_latency0.86857557
61MP0002429_abnormal_blood_cell0.86839181
62MP0001819_abnormal_immune_cell0.86819933
63MP0003763_abnormal_thymus_physiology0.85831188
64MP0009053_abnormal_anal_canal0.84229367
65MP0003879_abnormal_hair_cell0.82802120
66MP0003011_delayed_dark_adaptation0.82606778
67MP0000465_gastrointestinal_hemorrhage0.82007094
68MP0005666_abnormal_adipose_tissue0.81715070
69MP0000343_altered_response_to0.81368310
70MP0002127_abnormal_cardiovascular_syste0.78809916
71MP0002733_abnormal_thermal_nociception0.77922060
72MP0005397_hematopoietic_system_phenotyp0.77644936
73MP0001545_abnormal_hematopoietic_system0.77644936
74MP0000703_abnormal_thymus_morphology0.77340548
75MP0005084_abnormal_gallbladder_morpholo0.76813244
76MP0008995_early_reproductive_senescence0.76259409
77MP0003436_decreased_susceptibility_to0.75917443
78MP0000230_abnormal_systemic_arterial0.75055636
79MP0003111_abnormal_nucleus_morphology0.73549086
80MP0009764_decreased_sensitivity_to0.73488465
81MP0005551_abnormal_eye_electrophysiolog0.73040164
82MP0005535_abnormal_body_temperature0.70652081
83MP0000313_abnormal_cell_death0.69739797
84MP0002148_abnormal_hypersensitivity_rea0.65580537
85MP0005253_abnormal_eye_physiology0.65368972
86MP0000534_abnormal_ureter_morphology0.64608061
87MP0004742_abnormal_vestibular_system0.64567331
88MP0002332_abnormal_exercise_endurance0.64422543
89MP0009333_abnormal_splenocyte_physiolog0.64102615
90MP0005395_other_phenotype0.62794236
91MP0004134_abnormal_chest_morphology0.61147264
92MP0001986_abnormal_taste_sensitivity0.60280669
93MP0005025_abnormal_response_to0.60097159
94MP0010386_abnormal_urinary_bladder0.57232625
95MP0003045_fibrosis0.57027309
96MP0002282_abnormal_trachea_morphology0.55631619
97MP0001970_abnormal_pain_threshold0.55609002
98MP0003638_abnormal_response/metabolism_0.54035261
99MP0001533_abnormal_skeleton_physiology0.53767269
100MP0002736_abnormal_nociception_after0.53655547

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.85646011
2Severe visual impairment (HP:0001141)5.07364505
3Absent/shortened dynein arms (HP:0200106)4.58392579
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.58392579
5Increased mean platelet volume (HP:0011877)4.40345925
6Menorrhagia (HP:0000132)4.37545211
7Abnormal platelet volume (HP:0011876)4.21258649
8Chronic hepatic failure (HP:0100626)4.14648082
9Hyperkalemia (HP:0002153)3.99599836
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.98356885
11Male infertility (HP:0003251)3.93753911
12Attenuation of retinal blood vessels (HP:0007843)3.91010311
13Abnormal ciliary motility (HP:0012262)3.90079466
14Tubulointerstitial nephritis (HP:0001970)3.88455106
15Petechiae (HP:0000967)3.87437116
16Epistaxis (HP:0000421)3.77297381
17Abnormal respiratory motile cilium morphology (HP:0005938)3.67685355
18Abnormal respiratory epithelium morphology (HP:0012253)3.67685355
19Bony spicule pigmentary retinopathy (HP:0007737)3.62439136
20Infertility (HP:0000789)3.48795824
21Purpura (HP:0000979)3.33923482
22Abnormal spermatogenesis (HP:0008669)3.33492371
23Nasal polyposis (HP:0100582)3.33230475
24Abnormal respiratory motile cilium physiology (HP:0012261)3.30158597
25Hyperlipoproteinemia (HP:0010980)3.12968845
26Gingival bleeding (HP:0000225)3.06875846
27Acute hepatic failure (HP:0006554)2.91927921
28Impaired platelet aggregation (HP:0003540)2.77682266
29Abnormal platelet function (HP:0011869)2.77682266
30Cone-rod dystrophy (HP:0000548)2.77311978
31Aplasia/Hypoplasia of the earlobes (HP:0009906)2.75522104
32Azoospermia (HP:0000027)2.75366319
33Spontaneous hematomas (HP:0007420)2.74339038
34Upper limb muscle weakness (HP:0003484)2.70043075
35Poikilocytosis (HP:0004447)2.65390823
36Abnormality of endocrine pancreas physiology (HP:0012093)2.57100896
37Abnormality of the pancreatic islet cells (HP:0006476)2.57100896
38Truncal obesity (HP:0001956)2.51382483
39Resting tremor (HP:0002322)2.50588087
40Abnormality of the nasal mucosa (HP:0000433)2.49525139
41Hypophosphatemic rickets (HP:0004912)2.49367404
42Progressive cerebellar ataxia (HP:0002073)2.49080284
43Impulsivity (HP:0100710)2.47929017
44Progressive sensorineural hearing impairment (HP:0000408)2.47556572
45Paralysis (HP:0003470)2.46083995
46Papilledema (HP:0001085)2.45493443
47Abnormality of macular pigmentation (HP:0008002)2.37428456
48Cerebellar dysplasia (HP:0007033)2.31567302
49Menstrual irregularities (HP:0000858)2.27296604
50Horizontal nystagmus (HP:0000666)2.24615838
51Termporal pattern (HP:0011008)2.23695127
52Insidious onset (HP:0003587)2.23695127
53Pendular nystagmus (HP:0012043)2.18682466
54Abnormality of lateral ventricle (HP:0030047)2.16270440
55Spontaneous abortion (HP:0005268)2.15852575
56Postural instability (HP:0002172)2.12789493
57Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.07398802
58Tinnitus (HP:0000360)2.05969743
59Pancreatic islet-cell hyperplasia (HP:0004510)2.02443133
60Acanthocytosis (HP:0001927)2.01716191
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99923805
62Dyschromatopsia (HP:0007641)1.99459810
63Potter facies (HP:0002009)1.98583275
64Facial shape deformation (HP:0011334)1.98583275
65Portal hypertension (HP:0001409)1.96023747
66Hypoalphalipoproteinemia (HP:0003233)1.95430629
67Bronchiectasis (HP:0002110)1.95341807
68Decreased central vision (HP:0007663)1.91339123
69Prominent nose (HP:0000448)1.90504553
70Recurrent pneumonia (HP:0006532)1.89364414
71Abnormality of the hepatic vasculature (HP:0006707)1.86837423
72Easy fatigability (HP:0003388)1.85960238
73Colitis (HP:0002583)1.84676641
74Retinal dysplasia (HP:0007973)1.82893695
75Ectopic kidney (HP:0000086)1.81607889
76Recurrent sinusitis (HP:0011108)1.81000155
77Asymmetric septal hypertrophy (HP:0001670)1.78787442
78Cystic hygroma (HP:0000476)1.78677808
79Submucous cleft hard palate (HP:0000176)1.78664699
80Rhinitis (HP:0012384)1.78065661
81Abnormality of potassium homeostasis (HP:0011042)1.77359944
82Inflammation of the large intestine (HP:0002037)1.77118696
83Hypoplastic ischia (HP:0003175)1.76895579
84Increased density of long bones (HP:0006392)1.76692578
85Abnormal pupillary function (HP:0007686)1.75384852
86Abnormality of the prostate (HP:0008775)1.74244958
87Type II lissencephaly (HP:0007260)1.73801111
88Bruising susceptibility (HP:0000978)1.73321191
89Gastrointestinal inflammation (HP:0004386)1.71894245
90Failure to thrive in infancy (HP:0001531)1.70750487
91Abnormal rod and cone electroretinograms (HP:0008323)1.70287392
92Progressive hearing impairment (HP:0001730)1.69747012
93Intellectual disability, profound (HP:0002187)1.68246613
94Nonprogressive disorder (HP:0003680)1.67261935
95Abnormality of the fingertips (HP:0001211)1.64545752
96Enlarged epiphyses (HP:0010580)1.64287062
97Abnormality of the heme biosynthetic pathway (HP:0010472)1.64196379
98Hypoplasia of the thymus (HP:0000778)1.62339929
99Bell-shaped thorax (HP:0001591)1.62232659
100Chronic sinusitis (HP:0011109)1.62136287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.48444054
2MUSK3.95212622
3RIPK43.15205547
4PNCK3.08489077
5TESK12.97459912
6STK382.69533896
7CDK122.62620178
8PIK3CG2.55146657
9MAP4K22.14840682
10BRSK22.09774278
11TRIM281.98967369
12AKT31.91200737
13IRAK11.90297411
14MST41.83378346
15CAMK1G1.81930569
16PLK21.81538319
17BRD41.79799340
18PDK11.76958014
19BTK1.65764463
20TEC1.60010031
21MARK31.59106188
22PTK2B1.57877905
23DDR21.56795084
24PDPK11.49705410
25MAP3K101.45939188
26PDK21.44411384
27SYK1.43874936
28MAPK151.41934897
29NEK61.38630079
30SIK21.35360851
31SIK31.33952109
32BMPR1B1.25354622
33TESK21.10215023
34STK38L1.05423940
35MAP3K21.03705015
36CSF1R1.00826398
37BMX1.00079335
38EIF2AK30.99168339
39INSRR0.97241025
40GRK60.92574784
41FRK0.92527196
42MYLK0.91223561
43CDK70.88345315
44BLK0.87541712
45HCK0.87267142
46IKBKB0.86922304
47PKN10.86653168
48MAP4K10.83849407
49WNK10.79068082
50MAPK70.78695592
51KSR20.73570672
52MAPKAPK50.72031540
53TAOK30.71740695
54PAK10.70181908
55LYN0.68795822
56LMTK20.67574854
57BRAF0.66702324
58MAP3K30.63996004
59MAP3K130.63494484
60CDK30.63449994
61PRKG10.63385378
62TNK20.59924642
63STK30.58188419
64FER0.58136962
65MAPK110.55762455
66IRAK40.54100554
67DYRK30.51536080
68NEK20.51532267
69CDK90.51402312
70CAMK1D0.47017083
71BRSK10.46768299
72SGK20.44951217
73CDK40.43674546
74MAPK10.43179343
75EPHB10.42027902
76ITK0.41646137
77DYRK1B0.41485255
78BMPR20.39342170
79ZAP700.39114139
80MAP3K40.37855208
81ACVR1B0.34919888
82PRKCQ0.34722406
83MAPK120.34711940
84CDK20.32510209
85PRKCB0.31605099
86EIF2AK10.31582234
87CDK10.31575521
88EEF2K0.30193385
89PRKAA20.29886916
90CHEK10.29382061
91ROCK10.28549674
92ATR0.28148410
93CCNB10.27917625
94PRKD10.27708326
95RPS6KA10.27334720
96MAPK140.27285991
97GSK3B0.27262134
98CHUK0.27210041
99PRKAA10.26884601
100STK40.24336578

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.91713955
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.68002002
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.14040620
4Platelet activation_Homo sapiens_hsa046112.84309335
5Olfactory transduction_Homo sapiens_hsa047402.39645294
6B cell receptor signaling pathway_Homo sapiens_hsa046622.34114539
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.95932213
8Alcoholism_Homo sapiens_hsa050341.88631822
9Systemic lupus erythematosus_Homo sapiens_hsa053221.75997521
10Butanoate metabolism_Homo sapiens_hsa006501.61742370
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59490313
12Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.57287598
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.57049312
14Type II diabetes mellitus_Homo sapiens_hsa049301.42015959
15Viral carcinogenesis_Homo sapiens_hsa052031.40967058
16Chemokine signaling pathway_Homo sapiens_hsa040621.37606231
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35138232
18Inositol phosphate metabolism_Homo sapiens_hsa005621.30812550
19Graft-versus-host disease_Homo sapiens_hsa053321.30738090
20Morphine addiction_Homo sapiens_hsa050321.27013439
21Influenza A_Homo sapiens_hsa051641.25493526
22Antigen processing and presentation_Homo sapiens_hsa046121.24891130
23Hematopoietic cell lineage_Homo sapiens_hsa046401.23857590
24Taste transduction_Homo sapiens_hsa047421.17076591
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.16981054
26Allograft rejection_Homo sapiens_hsa053301.16139078
27Autoimmune thyroid disease_Homo sapiens_hsa053201.14178105
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11899547
29Nitrogen metabolism_Homo sapiens_hsa009101.09624270
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05469112
31Endocytosis_Homo sapiens_hsa041441.04563897
32Dorso-ventral axis formation_Homo sapiens_hsa043201.04244174
33Oocyte meiosis_Homo sapiens_hsa041141.01479120
34Gap junction_Homo sapiens_hsa045401.00765746
35Phototransduction_Homo sapiens_hsa047441.00614561
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95810101
37Measles_Homo sapiens_hsa051620.94065653
38Serotonergic synapse_Homo sapiens_hsa047260.93338752
39Type I diabetes mellitus_Homo sapiens_hsa049400.92465625
40Circadian entrainment_Homo sapiens_hsa047130.90407824
41Acute myeloid leukemia_Homo sapiens_hsa052210.90390374
42Choline metabolism in cancer_Homo sapiens_hsa052310.89042924
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.88768785
44Non-small cell lung cancer_Homo sapiens_hsa052230.82747209
45Estrogen signaling pathway_Homo sapiens_hsa049150.78616491
46Herpes simplex infection_Homo sapiens_hsa051680.78402897
47Long-term depression_Homo sapiens_hsa047300.78111873
48RNA transport_Homo sapiens_hsa030130.75468334
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.75234690
50Prolactin signaling pathway_Homo sapiens_hsa049170.75225902
51Fanconi anemia pathway_Homo sapiens_hsa034600.74759102
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74630582
53T cell receptor signaling pathway_Homo sapiens_hsa046600.74624635
54Fatty acid elongation_Homo sapiens_hsa000620.74510105
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.74055228
56Basal transcription factors_Homo sapiens_hsa030220.73916662
57Viral myocarditis_Homo sapiens_hsa054160.73409959
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72007276
59Primary immunodeficiency_Homo sapiens_hsa053400.70518983
60Cholinergic synapse_Homo sapiens_hsa047250.70501310
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.67261135
62Calcium signaling pathway_Homo sapiens_hsa040200.66364649
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65755450
64Cell cycle_Homo sapiens_hsa041100.65712627
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65035225
66Legionellosis_Homo sapiens_hsa051340.64320543
67Glycerolipid metabolism_Homo sapiens_hsa005610.63967124
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63940916
69Epstein-Barr virus infection_Homo sapiens_hsa051690.62110000
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61775427
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57922135
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.57693258
73Lysine degradation_Homo sapiens_hsa003100.57678744
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57207412
75GABAergic synapse_Homo sapiens_hsa047270.56582539
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56579127
77Prostate cancer_Homo sapiens_hsa052150.56557031
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55960044
79ABC transporters_Homo sapiens_hsa020100.53356647
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53085338
81Toxoplasmosis_Homo sapiens_hsa051450.52701317
82Pancreatic secretion_Homo sapiens_hsa049720.52337623
83VEGF signaling pathway_Homo sapiens_hsa043700.51818778
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51285233
85FoxO signaling pathway_Homo sapiens_hsa040680.50286355
86Oxytocin signaling pathway_Homo sapiens_hsa049210.50050639
87Hepatitis B_Homo sapiens_hsa051610.48716214
88Endometrial cancer_Homo sapiens_hsa052130.48050783
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47946750
90Osteoclast differentiation_Homo sapiens_hsa043800.45366680
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45355140
92MAPK signaling pathway_Homo sapiens_hsa040100.44384961
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43785609
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42184973
95Collecting duct acid secretion_Homo sapiens_hsa049660.41952466
96Apoptosis_Homo sapiens_hsa042100.41558771
97cAMP signaling pathway_Homo sapiens_hsa040240.41522819
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40021884
99Glioma_Homo sapiens_hsa052140.39913976
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39311254

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