C3ORF36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)8.54940102
2glucocorticoid metabolic process (GO:0008211)8.34653192
3amyloid precursor protein catabolic process (GO:0042987)8.15158138
4sexual reproduction (GO:0019953)7.65741571
5cellular response to follicle-stimulating hormone stimulus (GO:0071372)7.25460475
6low-density lipoprotein particle clearance (GO:0034383)6.87897512
7adhesion of symbiont to host (GO:0044406)6.46376309
8cellular response to gonadotropin stimulus (GO:0071371)6.40912302
9estrogen biosynthetic process (GO:0006703)6.11092282
10regulation of transforming growth factor beta2 production (GO:0032909)6.10420106
11growth hormone secretion (GO:0030252)5.96338969
12response to follicle-stimulating hormone (GO:0032354)5.76114401
13fibroblast migration (GO:0010761)5.73607379
14positive regulation of triglyceride biosynthetic process (GO:0010867)5.50488043
15amyloid precursor protein metabolic process (GO:0042982)5.24603673
16sodium-independent organic anion transport (GO:0043252)4.93754835
17positive regulation of astrocyte differentiation (GO:0048711)4.75981779
18positive regulation of nitric-oxide synthase activity (GO:0051000)4.75391012
19response to gonadotropin (GO:0034698)4.74057453
20cellular response to epinephrine stimulus (GO:0071872)4.72342582
21male genitalia development (GO:0030539)4.67950687
22phagocytosis, recognition (GO:0006910)4.56338026
23icosanoid transport (GO:0071715)4.55851916
24fatty acid derivative transport (GO:1901571)4.55851916
25positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.55427775
26hormone biosynthetic process (GO:0042446)4.49704510
27androgen metabolic process (GO:0008209)4.45443215
28hemoglobin metabolic process (GO:0020027)4.45371403
29endocrine hormone secretion (GO:0060986)4.43356174
30detection of molecule of bacterial origin (GO:0032490)4.42291658
31C21-steroid hormone biosynthetic process (GO:0006700)4.36626125
32regulation of triglyceride biosynthetic process (GO:0010866)4.36469137
33positive regulation of male gonad development (GO:2000020)4.35960299
34regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.19862686
35regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.18849343
36negative regulation of catenin import into nucleus (GO:0035414)4.15120260
37positive regulation of triglyceride metabolic process (GO:0090208)4.14222273
38interleukin-6-mediated signaling pathway (GO:0070102)4.12091947
39response to epinephrine (GO:0071871)4.01344532
40negative regulation of macrophage differentiation (GO:0045650)3.97933103
41regulation of gonadotropin secretion (GO:0032276)3.95678473
42negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.87228283
43regulation of cholesterol storage (GO:0010885)3.87132102
44sterol catabolic process (GO:0016127)3.85002748
45cholesterol catabolic process (GO:0006707)3.85002748
46regulation of cardioblast differentiation (GO:0051890)3.79788254
47cellular response to growth hormone stimulus (GO:0071378)3.79359670
48endothelial cell proliferation (GO:0001935)3.78598803
49endothelial cell chemotaxis (GO:0035767)3.75941858
50regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.66135734
51blood vessel endothelial cell migration (GO:0043534)3.60330161
52reproductive system development (GO:0061458)3.59937819
53cellular response to antibiotic (GO:0071236)3.59601216
54vitamin A metabolic process (GO:0006776)3.50578655
55regulation of male gonad development (GO:2000018)3.44001369
56prostaglandin metabolic process (GO:0006693)3.33780854
57prostanoid metabolic process (GO:0006692)3.33780854
58cellular response to cadmium ion (GO:0071276)3.29319113
59regulation of transforming growth factor beta1 production (GO:0032908)3.19874274
60face development (GO:0060324)3.16218615
61high-density lipoprotein particle remodeling (GO:0034375)3.15667804
62regulation of triglyceride metabolic process (GO:0090207)3.11568166
63collecting duct development (GO:0072044)3.06146344
64DNA strand renaturation (GO:0000733)3.06030040
65positive regulation of steroid hormone secretion (GO:2000833)3.04059319
66nephron tubule formation (GO:0072079)3.01038858
67positive regulation of monooxygenase activity (GO:0032770)2.99768466
68organic cation transport (GO:0015695)2.99460685
69regulation of mesenchymal cell apoptotic process (GO:2001053)2.94249169
70positive regulation of hormone metabolic process (GO:0032352)2.87866884
71reverse cholesterol transport (GO:0043691)2.87532027
72cellular response to interferon-alpha (GO:0035457)2.86750439
73benzene-containing compound metabolic process (GO:0042537)2.86701202
74progesterone metabolic process (GO:0042448)2.86066935
75regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85533019
76negative regulation of fatty acid transport (GO:2000192)2.84410721
77substrate-dependent cell migration (GO:0006929)2.84172418
78cranial nerve structural organization (GO:0021604)2.81849554
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.81285726
80outflow tract septum morphogenesis (GO:0003148)2.80609250
81regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.78968369
82desmosome organization (GO:0002934)2.75981677
83cell volume homeostasis (GO:0006884)2.74930883
84drug transmembrane transport (GO:0006855)2.73404468
85cellular response to toxic substance (GO:0097237)2.69151120
86negative regulation of axon extension involved in axon guidance (GO:0048843)2.65395214
87regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.63675632
88positive regulation of hormone biosynthetic process (GO:0046886)2.61574230
89regulation of corticosteroid hormone secretion (GO:2000846)2.60638397
90cellular response to dexamethasone stimulus (GO:0071549)2.59550864
91estrogen metabolic process (GO:0008210)2.59511255
92smooth muscle tissue development (GO:0048745)2.59382210
93chondroitin sulfate biosynthetic process (GO:0030206)2.57897954
94dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57647933
95actin filament depolymerization (GO:0030042)2.55258482
96steroid biosynthetic process (GO:0006694)2.54801562
97facial nerve structural organization (GO:0021612)2.54771653
98muscle hypertrophy in response to stress (GO:0003299)2.54063643
99cardiac muscle adaptation (GO:0014887)2.54063643
100glucocorticoid biosynthetic process (GO:0006704)10.8441322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.73730557
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.33771949
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.73048908
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.64496287
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.58362006
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.54101529
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43579350
8CLOCK_20551151_ChIP-Seq_293T_Human2.41118051
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35043984
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.23211476
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.12090672
12ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.11556785
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98011931
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96017530
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.85798726
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82657495
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79685216
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78607386
19CDX2_20551321_ChIP-Seq_CACO-2_Human1.77470807
20AHR_22903824_ChIP-Seq_MCF-7_Human1.77414714
21ARNT_22903824_ChIP-Seq_MCF-7_Human1.76195774
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75806795
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.75801160
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.68129804
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58346558
26NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56865574
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56786975
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56724905
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56323652
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46879712
31* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46062491
32* RUNX1_27514584_Chip-Seq_MCF-7_Human1.45935038
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39169305
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38045883
35KDM2B_26808549_Chip-Seq_K562_Human1.36624846
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33529169
37PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33528914
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32451128
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30719515
40TBX20_22080862_ChIP-Seq_HEART_Mouse1.30475032
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.30475032
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27215035
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25808617
44LXR_22292898_ChIP-Seq_THP-1_Human1.21875051
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.21800992
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21274113
47VDR_24787735_ChIP-Seq_THP-1_Human1.21014769
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20483226
49CJUN_26792858_Chip-Seq_BT549_Human1.19979859
50SMAD3_21741376_ChIP-Seq_HESCs_Human1.18700221
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17476600
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16947282
53SMAD4_21741376_ChIP-Seq_HESCs_Human1.16497579
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.16456595
55JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13627499
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12006959
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11949064
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11949064
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10239204
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10130906
61GATA1_19941826_ChIP-Seq_K562_Human1.10130886
62AR_21572438_ChIP-Seq_LNCaP_Human1.09756903
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.08261723
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.06608634
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06384736
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06272845
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06165492
68RACK7_27058665_Chip-Seq_MCF-7_Human1.05028832
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04400610
70GF1_26923725_Chip-Seq_HPCs_Mouse1.03308248
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02105468
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01708948
73DROSHA_22980978_ChIP-Seq_HELA_Human1.00793257
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00692446
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99502647
76ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98804713
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97685756
78NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97657768
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97139718
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96381906
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96258958
82P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95467699
83GATA3_24758297_ChIP-Seq_MCF-7_Human0.94524125
84PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93967986
85GATA2_19941826_ChIP-Seq_K562_Human0.93908180
86KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93517301
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92822195
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92109023
89KDM2B_26808549_Chip-Seq_DND41_Human0.90984502
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89851134
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89752879
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88441939
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87838842
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.87788336
95EGR1_19032775_ChIP-ChIP_M12_Human0.86352436
96SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85827959
97RNF2_27304074_Chip-Seq_ESCs_Mouse0.84283747
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84053996
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83678290
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.82861060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.88088538
2MP0003300_gastrointestinal_ulcer4.82275663
3MP0003011_delayed_dark_adaptation2.79264080
4MP0008875_abnormal_xenobiotic_pharmacok2.77019454
5MP0002876_abnormal_thyroid_physiology2.68474445
6MP0003724_increased_susceptibility_to2.40173646
7MP0005670_abnormal_white_adipose2.36824960
8MP0004233_abnormal_muscle_weight2.26963458
9MP0010329_abnormal_lipoprotein_level2.15147245
10MP0002332_abnormal_exercise_endurance2.04909162
11MP0003279_aneurysm2.01343080
12MP0000639_abnormal_adrenal_gland2.01072175
13MP0010368_abnormal_lymphatic_system1.98547467
14MP0000462_abnormal_digestive_system1.89560837
15MP0003566_abnormal_cell_adhesion1.78083463
16MP0001873_stomach_inflammation1.77810345
17MP0000013_abnormal_adipose_tissue1.75333189
18MP0002877_abnormal_melanocyte_morpholog1.73721666
19MP0005076_abnormal_cell_differentiation1.69920589
20MP0005334_abnormal_fat_pad1.69015419
21MP0010386_abnormal_urinary_bladder1.66383823
22MP0001661_extended_life_span1.65698264
23MP0002896_abnormal_bone_mineralization1.64497399
24MP0004883_abnormal_blood_vessel1.58193218
25MP0003828_pulmonary_edema1.57756775
26MP0005508_abnormal_skeleton_morphology1.56752799
27MP0004272_abnormal_basement_membrane1.56496221
28MP0000767_abnormal_smooth_muscle1.54870496
29MP0005595_abnormal_vascular_smooth1.50269792
30MP0005023_abnormal_wound_healing1.47972479
31MP0002998_abnormal_bone_remodeling1.42534309
32MP0009840_abnormal_foam_cell1.41265654
33MP0002127_abnormal_cardiovascular_syste1.39344644
34MP0000465_gastrointestinal_hemorrhage1.38621310
35MP0005164_abnormal_response_to1.38292017
36MP0004782_abnormal_surfactant_physiolog1.32876119
37MP0002933_joint_inflammation1.32365828
38MP0003091_abnormal_cell_migration1.31242017
39MP0005365_abnormal_bile_salt1.26051738
40MP0001501_abnormal_sleep_pattern1.24958943
41MP0001851_eye_inflammation1.23645100
42MP0005666_abnormal_adipose_tissue1.20470816
43MP0000534_abnormal_ureter_morphology1.18261806
44MP0000538_abnormal_urinary_bladder1.15664365
45MP0000681_abnormal_thyroid_gland1.13327063
46MP0005375_adipose_tissue_phenotype1.11023756
47MP0001958_emphysema1.09062769
48MP0001756_abnormal_urination1.08568554
49MP0009250_abnormal_appendicular_skeleto1.06760539
50MP0004510_myositis1.05976707
51MP0005409_darkened_coat_color1.05620598
52MP0001881_abnormal_mammary_gland1.01299451
53MP0002932_abnormal_joint_morphology1.00915593
54MP0004084_abnormal_cardiac_muscle0.99806443
55MP0002118_abnormal_lipid_homeostasis0.99222036
56MP0004036_abnormal_muscle_relaxation0.94721690
57MP0003953_abnormal_hormone_level0.94572519
58MP0002138_abnormal_hepatobiliary_system0.92651953
59MP0008438_abnormal_cutaneous_collagen0.92236169
60MP0002909_abnormal_adrenal_gland0.91983537
61MP0005390_skeleton_phenotype0.91935729
62MP0003936_abnormal_reproductive_system0.90764969
63MP0003705_abnormal_hypodermis_morpholog0.89129271
64MP0004215_abnormal_myocardial_fiber0.88226141
65MP0000627_abnormal_mammary_gland0.87086996
66MP0003879_abnormal_hair_cell0.83545948
67MP0001502_abnormal_circadian_rhythm0.82235804
68MP0000470_abnormal_stomach_morphology0.81410459
69MP0000003_abnormal_adipose_tissue0.80885966
70MP0004808_abnormal_hematopoietic_stem0.79514496
71MP0009384_cardiac_valve_regurgitation0.78139803
72MP0008775_abnormal_heart_ventricle0.77968875
73MP0005085_abnormal_gallbladder_physiolo0.76747383
74MP0002970_abnormal_white_adipose0.76482819
75MP0002282_abnormal_trachea_morphology0.74717479
76MP0003699_abnormal_female_reproductive0.73257840
77MP0000230_abnormal_systemic_arterial0.71153417
78MP0003045_fibrosis0.70334180
79MP0005083_abnormal_biliary_tract0.68957893
80MP0005330_cardiomyopathy0.68404633
81MP0001614_abnormal_blood_vessel0.68176457
82MP0008961_abnormal_basal_metabolism0.68097080
83MP0000249_abnormal_blood_vessel0.67766175
84MP0003385_abnormal_body_wall0.66764301
85MP0004145_abnormal_muscle_electrophysio0.65763666
86MP0000678_abnormal_parathyroid_gland0.64333174
87MP0002128_abnormal_blood_circulation0.63585181
88MP0000163_abnormal_cartilage_morphology0.62675095
89MP0001663_abnormal_digestive_system0.61939419
90MP0001440_abnormal_grooming_behavior0.61928986
91MP0002925_abnormal_cardiovascular_devel0.61494447
92MP0001270_distended_abdomen0.61080974
93MP0002269_muscular_atrophy0.60819301
94MP0006138_congestive_heart_failure0.60308141
95MP0003795_abnormal_bone_structure0.59411956
96MP0000049_abnormal_middle_ear0.57653223
97MP0005381_digestive/alimentary_phenotyp0.57532110
98MP0001533_abnormal_skeleton_physiology0.56994449
99MP0005448_abnormal_energy_balance0.56786449
100MP0002115_abnormal_skeleton_extremities0.56148169

Predicted human phenotypes

RankGene SetZ-score
1Anomalous pulmonary venous return (HP:0010772)7.61978737
2Abnormality of the pulmonary veins (HP:0011718)6.81102679
3Large earlobe (HP:0009748)6.44911343
4Relative macrocephaly (HP:0004482)5.67346414
5Cerebral palsy (HP:0100021)5.48697566
6Growth hormone excess (HP:0000845)5.10371928
7Partial agenesis of the corpus callosum (HP:0001338)4.88987367
8Rhizomelia (HP:0008905)4.11961284
9Abnormality of the alveolar ridges (HP:0006477)3.90783767
10Ureteral duplication (HP:0000073)3.88450087
11Cupped ear (HP:0000378)3.60644044
12Hyperpituitarism (HP:0010514)3.52087139
13Seborrheic dermatitis (HP:0001051)3.50628281
14Acanthosis nigricans (HP:0000956)3.43611458
15Short clavicles (HP:0000894)3.31296806
16Vertebral arch anomaly (HP:0008438)3.28901563
17Abnormality of the aortic arch (HP:0012303)3.19082502
18Aortic aneurysm (HP:0004942)3.18423294
19Stenosis of the external auditory canal (HP:0000402)3.14144270
20Hypoplastic nipples (HP:0002557)3.10113753
21Abnormal pancreas size (HP:0012094)3.07716381
22Aplasia/Hypoplasia of the clavicles (HP:0006710)2.96032624
23Ulnar bowing (HP:0003031)2.89834679
24Small epiphyses (HP:0010585)2.80844419
25Diastasis recti (HP:0001540)2.78254865
26Vertebral clefting (HP:0008428)2.76940046
27Aortic regurgitation (HP:0001659)2.63736784
28Congenital malformation of the right heart (HP:0011723)2.62682372
29Double outlet right ventricle (HP:0001719)2.62682372
30Mitral stenosis (HP:0001718)2.59016825
31Oligodactyly (hands) (HP:0001180)2.56465967
32Abnormality of carpal bone ossification (HP:0006257)2.52354902
33Renal salt wasting (HP:0000127)2.52277098
34Bronchomalacia (HP:0002780)2.50947884
35Gonadotropin excess (HP:0000837)2.50716543
36Patent foramen ovale (HP:0001655)2.47730433
37Short nail (HP:0001799)2.43804093
38Accelerated skeletal maturation (HP:0005616)2.42215910
39Intestinal malrotation (HP:0002566)2.40587180
40Spondylolisthesis (HP:0003302)2.39513093
41Persistence of primary teeth (HP:0006335)2.38529949
42Flattened epiphyses (HP:0003071)2.37170474
43Gynecomastia (HP:0000771)2.36591238
44Choroideremia (HP:0001139)2.35880838
45Broad face (HP:0000283)2.33760653
46Short humerus (HP:0005792)2.32609739
47Anteriorly placed anus (HP:0001545)2.32522741
48Split foot (HP:0001839)2.32164916
49Abnormal ossification of hand bones (HP:0005921)2.29575615
50Narrow nasal bridge (HP:0000446)2.26173367
51Aortic dissection (HP:0002647)2.26108253
52Insulin resistance (HP:0000855)2.24711104
53Hypoplasia of dental enamel (HP:0006297)2.24268088
54Limited hip movement (HP:0008800)2.23120493
55Osteomyelitis (HP:0002754)2.19665024
56Oligodontia (HP:0000677)2.19273114
57Acne (HP:0001061)2.17862496
58Joint swelling (HP:0001386)2.17481078
59Mixed hearing impairment (HP:0000410)2.17418666
60Cervical subluxation (HP:0003308)2.15531234
61Abnormality of the fetal cardiovascular system (HP:0010948)2.13681811
62Abnormal umbilical cord blood vessels (HP:0011403)2.13681811
63Single umbilical artery (HP:0001195)2.13681811
64Abnormal hand bone ossification (HP:0010660)2.12461341
65Aplasia/Hypoplasia of the scapulae (HP:0006713)2.09651379
66Hypoplastic scapulae (HP:0000882)2.09651379
67Abnormality of dentin (HP:0010299)2.08319834
68Ectopia lentis (HP:0001083)2.05481787
69Tibial bowing (HP:0002982)2.04719944
70Pulmonary artery stenosis (HP:0004415)2.03955733
71Bowing of the arm (HP:0006488)2.02337684
72Bowed forearm bones (HP:0003956)2.02337684
73Aplasia/hypoplasia of the humerus (HP:0006507)2.00055920
74Abnormal cortical bone morphology (HP:0003103)1.99626114
75Clubbing of toes (HP:0100760)1.99121069
76Genu varum (HP:0002970)1.97277680
77Increased density of long bones (HP:0006392)1.96754658
78Precocious puberty (HP:0000826)1.96035649
79Protrusio acetabuli (HP:0003179)1.91879420
80Flat acetabular roof (HP:0003180)1.91686521
81Absent frontal sinuses (HP:0002688)1.88135458
82Supernumerary nipples (HP:0002558)1.87362779
83Aplasia/hypoplasia of the femur (HP:0005613)1.86950546
84Fibroma (HP:0010614)1.86688607
85Joint laxity (HP:0001388)1.86268877
86Cerebral aneurysm (HP:0004944)1.86252332
87Neonatal death (HP:0003811)1.83451036
88Oligodactyly (HP:0012165)1.82841940
89Shawl scrotum (HP:0000049)1.80884692
90Progressive cerebellar ataxia (HP:0002073)1.80857711
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.80815405
92Fibrous tissue neoplasm (HP:0012316)1.80473537
93Syringomyelia (HP:0003396)1.79770801
94Spinal cord lesions (HP:0100561)1.79770801
95Neoplasm of the lung (HP:0100526)1.79739916
96Right ventricular cardiomyopathy (HP:0011663)1.77796946
97Limited elbow extension (HP:0001377)1.76102029
98Short middle phalanx of the 5th finger (HP:0004220)1.75798036
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75753333
100Abnormality of the gastric mucosa (HP:0004295)1.75211945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B6.91056401
2AKT35.85122558
3TAOK23.87174907
4MYLK3.04109141
5PIK3CG2.93396024
6DMPK2.70256956
7ERN12.31013591
8JAK12.10862951
9RIPK11.99922759
10LATS11.81324513
11TRIB31.77388344
12LMTK21.76466309
13STK381.72517394
14ICK1.68176068
15CDC42BPA1.60485552
16DDR21.58830434
17TTN1.54180666
18PDK21.50189399
19PKN21.49467894
20SIK11.44378368
21NLK1.43687332
22MAP3K71.35455169
23CAMK41.34295569
24EPHB11.33059082
25MTOR1.26695131
26PTK21.19953341
27TNIK1.16984279
28EPHA31.14718045
29STK38L1.11400773
30EPHB21.11173511
31ROCK11.07145775
32MAP2K20.96828127
33CAMK1G0.93315355
34MAPK70.92122008
35BRD40.90964492
36PAK20.88931600
37FER0.88531130
38INSRR0.86859471
39RPS6KA20.82093157
40PDGFRA0.81857169
41PDK10.81357432
42CAMK1D0.79862321
43CDK120.78602198
44MELK0.75291611
45MARK20.74420882
46NEK60.74029712
47PIK3CA0.73464399
48NME10.73185415
49LATS20.71850214
50RPS6KL10.69215020
51RPS6KC10.69215020
52PRKD20.68255955
53TAOK30.66636385
54ROCK20.66408446
55PDPK10.64668167
56MAP2K10.64134853
57RPS6KA50.64118218
58BCKDK0.63602548
59MAPK30.62867603
60MAPK10.61531356
61HIPK20.61110776
62RPS6KA60.60820638
63MAP3K60.60779181
64PDGFRB0.59306089
65FLT30.57698565
66ILK0.56504687
67TESK10.54023480
68PRKAA20.53927212
69PRKD30.52450527
70DYRK20.51637323
71TIE10.49889737
72JAK20.49475511
73MET0.49325893
74GSK3A0.49122748
75PTK2B0.47687284
76FGFR40.47411715
77WNK10.47318137
78MAPK120.46997025
79SGK20.43392489
80BMPR1B0.42504455
81RET0.42105725
82PRKG20.42096320
83NTRK10.41268619
84STK240.38365965
85MAPK40.37583724
86PRKD10.36869101
87PAK30.35416225
88CAMK10.35270363
89SGK30.35042902
90LRRK20.35008312
91CDK90.33570537
92PTK60.33068608
93SGK4940.32780474
94SGK2230.32780474
95MAP3K120.31688554
96STK110.30526406
97MAPK80.29825695
98CHUK0.28192473
99MAPK90.26172333
100STK100.26072897

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.96329594
2Ovarian steroidogenesis_Homo sapiens_hsa049134.92189546
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.04690900
4Aldosterone synthesis and secretion_Homo sapiens_hsa049253.41930430
5Vitamin digestion and absorption_Homo sapiens_hsa049772.79153434
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.52151712
7Bile secretion_Homo sapiens_hsa049761.75219131
8ECM-receptor interaction_Homo sapiens_hsa045121.68109739
9Fatty acid biosynthesis_Homo sapiens_hsa000611.60054766
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57897877
11Fat digestion and absorption_Homo sapiens_hsa049751.46249859
12Focal adhesion_Homo sapiens_hsa045101.43052874
13Arachidonic acid metabolism_Homo sapiens_hsa005901.41293021
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39167423
15Adherens junction_Homo sapiens_hsa045201.25949878
16Tight junction_Homo sapiens_hsa045301.22551638
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.19383956
18Hepatitis C_Homo sapiens_hsa051601.10588587
19Circadian rhythm_Homo sapiens_hsa047101.07716574
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07665963
21Dilated cardiomyopathy_Homo sapiens_hsa054141.07508406
22Pancreatic secretion_Homo sapiens_hsa049721.07065995
23Proteoglycans in cancer_Homo sapiens_hsa052051.04548031
24TGF-beta signaling pathway_Homo sapiens_hsa043501.02926439
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.02364703
26Gastric acid secretion_Homo sapiens_hsa049711.01922803
27Thyroid hormone synthesis_Homo sapiens_hsa049180.99672140
28Thyroid cancer_Homo sapiens_hsa052160.98158154
29Choline metabolism in cancer_Homo sapiens_hsa052310.92373224
30Chemical carcinogenesis_Homo sapiens_hsa052040.89008184
31Inositol phosphate metabolism_Homo sapiens_hsa005620.87436248
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86941300
33Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85334414
34Protein digestion and absorption_Homo sapiens_hsa049740.81109572
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80837807
36Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80681476
37TNF signaling pathway_Homo sapiens_hsa046680.79614739
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75637497
39Leukocyte transendothelial migration_Homo sapiens_hsa046700.75112613
40ABC transporters_Homo sapiens_hsa020100.74530624
41PPAR signaling pathway_Homo sapiens_hsa033200.73980592
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72128380
43Wnt signaling pathway_Homo sapiens_hsa043100.71927717
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71176836
45Amoebiasis_Homo sapiens_hsa051460.71074898
46VEGF signaling pathway_Homo sapiens_hsa043700.68753470
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68614911
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68533259
49Galactose metabolism_Homo sapiens_hsa000520.67311964
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66292751
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65810705
52GnRH signaling pathway_Homo sapiens_hsa049120.65618040
53Prolactin signaling pathway_Homo sapiens_hsa049170.64782226
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.63232009
55Salivary secretion_Homo sapiens_hsa049700.61929607
56Notch signaling pathway_Homo sapiens_hsa043300.61730119
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61458351
58Insulin signaling pathway_Homo sapiens_hsa049100.61365454
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.60156206
60Circadian entrainment_Homo sapiens_hsa047130.59294274
61Estrogen signaling pathway_Homo sapiens_hsa049150.59250212
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59154659
63Renal cell carcinoma_Homo sapiens_hsa052110.58275234
64Fatty acid metabolism_Homo sapiens_hsa012120.58045093
65Endometrial cancer_Homo sapiens_hsa052130.58032364
66Serotonergic synapse_Homo sapiens_hsa047260.57603007
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57268750
68Lysine degradation_Homo sapiens_hsa003100.56866474
69MAPK signaling pathway_Homo sapiens_hsa040100.56703436
70Type II diabetes mellitus_Homo sapiens_hsa049300.56105690
71ErbB signaling pathway_Homo sapiens_hsa040120.54583327
72Prion diseases_Homo sapiens_hsa050200.53368664
73mTOR signaling pathway_Homo sapiens_hsa041500.52953751
74Oxytocin signaling pathway_Homo sapiens_hsa049210.52435327
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52203457
76AMPK signaling pathway_Homo sapiens_hsa041520.51255701
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49828309
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49210343
79Dorso-ventral axis formation_Homo sapiens_hsa043200.48256317
80Renin secretion_Homo sapiens_hsa049240.48133011
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.47984000
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47796689
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46813522
84Hippo signaling pathway_Homo sapiens_hsa043900.45615543
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45385010
86Insulin resistance_Homo sapiens_hsa049310.44666514
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.44129577
88Complement and coagulation cascades_Homo sapiens_hsa046100.43641738
89cAMP signaling pathway_Homo sapiens_hsa040240.43561971
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.43250120
91Long-term potentiation_Homo sapiens_hsa047200.42225063
92HIF-1 signaling pathway_Homo sapiens_hsa040660.39810400
93Small cell lung cancer_Homo sapiens_hsa052220.39795616
94FoxO signaling pathway_Homo sapiens_hsa040680.39575382
95Fatty acid degradation_Homo sapiens_hsa000710.39439916
96beta-Alanine metabolism_Homo sapiens_hsa004100.39015100
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38512044
98Long-term depression_Homo sapiens_hsa047300.37806916
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37206382
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37058201

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