C3ORF38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)4.98811174
2mitotic metaphase plate congression (GO:0007080)4.69826728
3DNA double-strand break processing (GO:0000729)4.55992086
4metaphase plate congression (GO:0051310)4.45516003
5cullin deneddylation (GO:0010388)4.16303347
6establishment of chromosome localization (GO:0051303)4.09018263
7protein deneddylation (GO:0000338)3.90768250
8DNA catabolic process, exonucleolytic (GO:0000738)3.83121312
9CENP-A containing nucleosome assembly (GO:0034080)3.82881580
10chromatin remodeling at centromere (GO:0031055)3.77926394
11regulation of centriole replication (GO:0046599)3.70347682
12protein localization to kinetochore (GO:0034501)3.62352097
13regulation of helicase activity (GO:0051095)3.54257059
14histone exchange (GO:0043486)3.50818701
15DNA ligation (GO:0006266)3.45399901
16maturation of 5.8S rRNA (GO:0000460)3.44548971
17proteasome assembly (GO:0043248)3.42030487
18RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.41617283
19establishment of integrated proviral latency (GO:0075713)3.36855898
20negative regulation of DNA recombination (GO:0045910)3.29490304
21mitotic G2/M transition checkpoint (GO:0044818)3.29421279
22rRNA methylation (GO:0031167)3.26789366
23somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.26761717
24somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.26761717
25isotype switching (GO:0045190)3.26761717
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.26279725
27transcription from mitochondrial promoter (GO:0006390)3.24610209
28histone H2A acetylation (GO:0043968)3.21953723
29attachment of spindle microtubules to kinetochore (GO:0008608)3.21908318
30double-strand break repair via nonhomologous end joining (GO:0006303)3.21807073
31non-recombinational repair (GO:0000726)3.21807073
32protein localization to chromosome, centromeric region (GO:0071459)3.21418577
33DNA replication-dependent nucleosome assembly (GO:0006335)3.20597944
34DNA replication-dependent nucleosome organization (GO:0034723)3.20597944
35DNA replication checkpoint (GO:0000076)3.14475760
36spindle checkpoint (GO:0031577)3.13779578
37DNA replication-independent nucleosome organization (GO:0034724)3.13210215
38DNA replication-independent nucleosome assembly (GO:0006336)3.13210215
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11778740
40protein K6-linked ubiquitination (GO:0085020)3.10834528
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03693409
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.03205441
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03205441
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03205441
45histone mRNA metabolic process (GO:0008334)3.02944587
46rRNA modification (GO:0000154)3.02511224
47synapsis (GO:0007129)3.02250296
48transcription elongation from RNA polymerase I promoter (GO:0006362)3.00588220
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00280416
50protein neddylation (GO:0045116)2.99067333
51regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98258648
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98258648
53regulation of mitotic spindle checkpoint (GO:1903504)2.96790312
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96790312
55DNA deamination (GO:0045006)2.96256412
56mitotic spindle checkpoint (GO:0071174)2.96208287
57regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.94338412
58positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.94338412
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93772745
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90879394
61folic acid-containing compound biosynthetic process (GO:0009396)2.88825789
62establishment of viral latency (GO:0019043)2.87959270
63IMP biosynthetic process (GO:0006188)2.87879707
64mitotic G2 DNA damage checkpoint (GO:0007095)2.87308583
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85398107
66termination of RNA polymerase I transcription (GO:0006363)2.83828269
67regulation of vitamin D biosynthetic process (GO:0060556)2.83703152
68centriole replication (GO:0007099)2.82661668
69purine nucleobase biosynthetic process (GO:0009113)2.82579496
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82183542
71replication fork processing (GO:0031297)2.82140677
72regulation of DNA endoreduplication (GO:0032875)2.80501981
73establishment of protein localization to mitochondrial membrane (GO:0090151)2.79638667
74negative regulation of sister chromatid segregation (GO:0033046)2.79113380
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79113380
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79113380
77negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79113380
78negative regulation of mitotic sister chromatid separation (GO:2000816)2.79113380
79regulation of sister chromatid segregation (GO:0033045)2.77842651
80regulation of mitotic sister chromatid separation (GO:0010965)2.77842651
81regulation of mitotic sister chromatid segregation (GO:0033047)2.77842651
82mitochondrial RNA metabolic process (GO:0000959)2.76706140
83positive regulation of translational initiation (GO:0045948)2.76164231
84telomere maintenance via semi-conservative replication (GO:0032201)2.76091343
85double-strand break repair via homologous recombination (GO:0000724)2.75891608
86regulation of DNA recombination (GO:0000018)2.75820856
87recombinational repair (GO:0000725)2.75674969
88negative regulation of chromosome segregation (GO:0051985)2.75009670
89response to X-ray (GO:0010165)2.72919830
90positive regulation of chromosome segregation (GO:0051984)2.71704936
91somatic recombination of immunoglobulin gene segments (GO:0016447)2.71169971
92regulation of MHC class II biosynthetic process (GO:0045346)2.69234696
93DNA strand elongation involved in DNA replication (GO:0006271)2.68635843
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64853888
95somatic hypermutation of immunoglobulin genes (GO:0016446)2.64853888
96DNA strand elongation (GO:0022616)2.63836349
97nucleobase biosynthetic process (GO:0046112)2.63320527
98regulation of isotype switching to IgG isotypes (GO:0048302)2.62498052
99mitotic spindle assembly checkpoint (GO:0007094)2.62251636
100regulation of chromosome segregation (GO:0051983)2.60887690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.42604281
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88743280
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60242514
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.39063274
5ELK1_19687146_ChIP-ChIP_HELA_Human2.86102284
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.79719833
7PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57137501
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49237954
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48335769
10* VDR_23849224_ChIP-Seq_CD4+_Human2.43706960
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30873982
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29910339
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.27137106
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24151965
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19998199
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.13651066
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12188355
18EWS_26573619_Chip-Seq_HEK293_Human2.06116303
19PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05579591
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05093084
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00757905
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98793283
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.97283509
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97045307
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87989527
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.87257259
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83592118
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.80810431
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.78842464
30* DCP1A_22483619_ChIP-Seq_HELA_Human1.77233929
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76420558
32IGF1R_20145208_ChIP-Seq_DFB_Human1.75676080
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73986403
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73716674
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69128581
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.67545248
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63211573
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59748018
39AR_21909140_ChIP-Seq_LNCAP_Human1.59128364
40FUS_26573619_Chip-Seq_HEK293_Human1.57983197
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56295676
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49704123
43TAF15_26573619_Chip-Seq_HEK293_Human1.48426884
44ZNF274_21170338_ChIP-Seq_K562_Hela1.47661863
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45103716
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44514461
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44327962
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44001671
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41747932
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38936985
51VDR_22108803_ChIP-Seq_LS180_Human1.38599319
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36572054
53P300_19829295_ChIP-Seq_ESCs_Human1.35162954
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32652151
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.28281234
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.24323338
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.24023636
58IRF1_19129219_ChIP-ChIP_H3396_Human1.23055358
59* GABP_19822575_ChIP-Seq_HepG2_Human1.21668963
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21353700
61SALL4_22934838_ChIP-ChIP_CD34+_Human1.20989244
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17363207
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16154071
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13258524
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.10934931
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10626773
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09893546
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.09594171
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09579112
70MYC_18940864_ChIP-ChIP_HL60_Human1.08335070
71TTF2_22483619_ChIP-Seq_HELA_Human1.07922287
72TFEB_21752829_ChIP-Seq_HELA_Human1.03356246
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01187720
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01141634
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99719112
76MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97368277
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97313009
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96990283
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.96315227
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94725406
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93083500
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92523424
83* ELK1_22589737_ChIP-Seq_MCF10A_Human0.92085702
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91658323
85MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91037693
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89891989
87* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89667400
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89351520
89ER_23166858_ChIP-Seq_MCF-7_Human0.89078196
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87479816
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87405098
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87118180
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.86727150
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85358139
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85292112
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84529133
97CBP_20019798_ChIP-Seq_JUKART_Human0.84529133
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84414122
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83726347
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83317319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.81841494
2MP0010094_abnormal_chromosome_stability3.43441970
3MP0003693_abnormal_embryo_hatching3.37773442
4MP0008058_abnormal_DNA_repair3.33956664
5MP0009697_abnormal_copulation3.24446235
6MP0004957_abnormal_blastocyst_morpholog2.87100820
7MP0003077_abnormal_cell_cycle2.82731288
8MP0008877_abnormal_DNA_methylation2.74785234
9MP0003718_maternal_effect2.68404639
10MP0003111_abnormal_nucleus_morphology2.64686387
11MP0001835_abnormal_antigen_presentation2.23886265
12MP0003890_abnormal_embryonic-extraembry2.19779527
13MP0002102_abnormal_ear_morphology2.14348945
14MP0008932_abnormal_embryonic_tissue2.12756053
15MP0008007_abnormal_cellular_replicative2.07930674
16MP0010307_abnormal_tumor_latency1.94641749
17MP0001293_anophthalmia1.92890166
18MP0003806_abnormal_nucleotide_metabolis1.85940516
19MP0005671_abnormal_response_to1.84749567
20MP0008789_abnormal_olfactory_epithelium1.78650444
21MP0000569_abnormal_digit_pigmentation1.77009559
22MP0009785_altered_susceptibility_to1.74163507
23MP0003221_abnormal_cardiomyocyte_apopto1.70672190
24MP0004782_abnormal_surfactant_physiolog1.68728740
25MP0002138_abnormal_hepatobiliary_system1.68250209
26MP0005499_abnormal_olfactory_system1.63630843
27MP0005394_taste/olfaction_phenotype1.63630843
28MP0001177_atelectasis1.48570612
29MP0001730_embryonic_growth_arrest1.45730432
30MP0006072_abnormal_retinal_apoptosis1.45125938
31MP0005248_abnormal_Harderian_gland1.44665662
32MP0002148_abnormal_hypersensitivity_rea1.43877925
33MP0001873_stomach_inflammation1.42063093
34MP0003567_abnormal_fetal_cardiomyocyte1.40077525
35MP0003941_abnormal_skin_development1.39312882
36MP0006292_abnormal_olfactory_placode1.36733945
37MP0003448_altered_tumor_morphology1.35073429
38MP0002254_reproductive_system_inflammat1.29708502
39MP0006035_abnormal_mitochondrial_morpho1.29467352
40MP0000490_abnormal_crypts_of1.26021756
41MP0000350_abnormal_cell_proliferation1.22890089
42MP0001790_abnormal_immune_system1.22812505
43MP0005387_immune_system_phenotype1.22812505
44MP0003186_abnormal_redox_activity1.21573296
45MP0001800_abnormal_humoral_immune1.20618764
46MP0010352_gastrointestinal_tract_polyps1.18956549
47MP0000358_abnormal_cell_content/1.12650987
48MP0005000_abnormal_immune_tolerance1.11683359
49MP0000313_abnormal_cell_death1.10667676
50MP0002006_tumorigenesis1.07815852
51MP0003303_peritoneal_inflammation1.07643529
52MP0001697_abnormal_embryo_size1.07042943
53MP0001853_heart_inflammation1.06675965
54MP0005380_embryogenesis_phenotype1.06261797
55MP0001672_abnormal_embryogenesis/_devel1.06261797
56MP0001929_abnormal_gametogenesis1.05600429
57MP0001119_abnormal_female_reproductive1.03958003
58MP0006054_spinal_hemorrhage1.03920630
59MP0001529_abnormal_vocalization1.00102922
60MP0002090_abnormal_vision1.00029770
61MP0008260_abnormal_autophagy0.99685225
62MP0002452_abnormal_antigen_presenting0.98394466
63MP0005395_other_phenotype0.98330575
64MP0006036_abnormal_mitochondrial_physio0.98194653
65MP0002751_abnormal_autonomic_nervous0.97791428
66MP0002233_abnormal_nose_morphology0.96533523
67MP0002332_abnormal_exercise_endurance0.96311147
68MP0002877_abnormal_melanocyte_morpholog0.92022241
69MP0002009_preneoplasia0.91884430
70MP0002405_respiratory_system_inflammati0.91705689
71MP0003786_premature_aging0.89597062
72MP0002723_abnormal_immune_serum0.88993691
73MP0005310_abnormal_salivary_gland0.87752727
74MP0005253_abnormal_eye_physiology0.87514165
75MP0000689_abnormal_spleen_morphology0.87079001
76MP0000516_abnormal_urinary_system0.87064520
77MP0005367_renal/urinary_system_phenotyp0.87064520
78MP0009765_abnormal_xenobiotic_induced0.86765935
79MP0002210_abnormal_sex_determination0.86124520
80MP0001984_abnormal_olfaction0.85419598
81MP0000685_abnormal_immune_system0.84424492
82MP0002019_abnormal_tumor_incidence0.83218581
83MP0003656_abnormal_erythrocyte_physiolo0.82980300
84MP0002088_abnormal_embryonic_growth/wei0.82724072
85MP0002166_altered_tumor_susceptibility0.81146707
86MP0009764_decreased_sensitivity_to0.80854411
87MP0005084_abnormal_gallbladder_morpholo0.79905802
88MP0000653_abnormal_sex_gland0.79558754
89MP0005647_abnormal_sex_gland0.79522304
90MP0003984_embryonic_growth_retardation0.79284409
91MP0002084_abnormal_developmental_patter0.79067523
92MP0002398_abnormal_bone_marrow0.78437811
93MP0006082_CNS_inflammation0.78099574
94MP0001727_abnormal_embryo_implantation0.77892099
95MP0004197_abnormal_fetal_growth/weight/0.77122327
96MP0009703_decreased_birth_body0.76082523
97MP0002420_abnormal_adaptive_immunity0.75903660
98MP0001764_abnormal_homeostasis0.74746708
99MP0001819_abnormal_immune_cell0.74647309
100MP0002722_abnormal_immune_system0.74637541

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.86084421
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68532885
3Chromsome breakage (HP:0040012)3.62632588
4Abnormality of chromosome stability (HP:0003220)3.60046830
5Cortical dysplasia (HP:0002539)3.34316217
6Papillary thyroid carcinoma (HP:0002895)3.30213808
7Meckel diverticulum (HP:0002245)3.15179387
8Colon cancer (HP:0003003)3.15120697
9Abnormality of the ileum (HP:0001549)3.01913549
10Medulloblastoma (HP:0002885)2.96675583
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.90209231
12Increased IgM level (HP:0003496)2.85060353
13Agnosia (HP:0010524)2.82895283
14Thyroid carcinoma (HP:0002890)2.77882129
15Carpal bone hypoplasia (HP:0001498)2.71840026
16Bile duct proliferation (HP:0001408)2.66516145
17Abnormal biliary tract physiology (HP:0012439)2.66516145
18Abnormality of the preputium (HP:0100587)2.62699931
19Abnormal lung lobation (HP:0002101)2.61713378
20Supernumerary spleens (HP:0009799)2.61080741
21Nephroblastoma (Wilms tumor) (HP:0002667)2.60851540
22Aplastic anemia (HP:0001915)2.59053806
23Embryonal renal neoplasm (HP:0011794)2.54948151
24Sloping forehead (HP:0000340)2.45134610
25Gonadotropin excess (HP:0000837)2.45015629
26Small intestinal stenosis (HP:0012848)2.44737565
27Duodenal stenosis (HP:0100867)2.44737565
28Rhabdomyosarcoma (HP:0002859)2.43198055
29IgA deficiency (HP:0002720)2.37772781
30Breast carcinoma (HP:0003002)2.34813268
31Biliary tract neoplasm (HP:0100574)2.33677371
32B lymphocytopenia (HP:0010976)2.29880536
33Volvulus (HP:0002580)2.28267962
34Curly hair (HP:0002212)2.22534904
35Abnormality of the metopic suture (HP:0005556)2.15642052
36Abnormal hair whorl (HP:0010721)2.13159993
37Abnormality of the duodenum (HP:0002246)2.09764676
38Prominent metopic ridge (HP:0005487)2.09132949
39Abnormality of B cell number (HP:0010975)2.09101386
40Bone marrow hypocellularity (HP:0005528)2.05254464
41Microvesicular hepatic steatosis (HP:0001414)2.04948543
42Transitional cell carcinoma of the bladder (HP:0006740)2.03387096
43Neoplasm of the adrenal cortex (HP:0100641)2.02948332
44Stomatitis (HP:0010280)2.02918566
45IgM deficiency (HP:0002850)2.00747336
46Hyperglycinemia (HP:0002154)2.00405337
47Multiple enchondromatosis (HP:0005701)1.97169175
48Clubbing of toes (HP:0100760)1.96507372
49Neoplasm of the adrenal gland (HP:0100631)1.95773397
50Ependymoma (HP:0002888)1.95437585
51Abnormality of methionine metabolism (HP:0010901)1.94990822
52Increased serum pyruvate (HP:0003542)1.94789581
53Autoimmune hemolytic anemia (HP:0001890)1.92191955
54Abnormality of the anterior horn cell (HP:0006802)1.89807435
55Degeneration of anterior horn cells (HP:0002398)1.89807435
56Nephrogenic diabetes insipidus (HP:0009806)1.88864716
57IgG deficiency (HP:0004315)1.88444149
58Neoplasm of the colon (HP:0100273)1.87138916
59Cystic hygroma (HP:0000476)1.85918543
60Myelodysplasia (HP:0002863)1.85377137
61Bladder neoplasm (HP:0009725)1.83943028
62Bladder carcinoma (HP:0002862)1.83943028
63Spastic diplegia (HP:0001264)1.83868259
64Abnormality of eosinophils (HP:0001879)1.83356783
65Abnormality of glycolysis (HP:0004366)1.83251430
66Oral leukoplakia (HP:0002745)1.81937119
67Chronic hepatic failure (HP:0100626)1.81643290
68Pancytopenia (HP:0001876)1.81481213
69Facial hemangioma (HP:0000329)1.81062405
70Combined immunodeficiency (HP:0005387)1.80839432
71Abnormality of the septum pellucidum (HP:0007375)1.80434309
72Increased hepatocellular lipid droplets (HP:0006565)1.79601449
73Atrophy/Degeneration involving motor neurons (HP:0007373)1.79397312
74Glioma (HP:0009733)1.79329037
75Congenital primary aphakia (HP:0007707)1.78860334
76Methylmalonic acidemia (HP:0002912)1.78545571
77Eosinophilia (HP:0001880)1.78177530
78Disinhibition (HP:0000734)1.77621664
79Lymphoma (HP:0002665)1.76863070
80Intestinal atresia (HP:0011100)1.73816862
81Progressive inability to walk (HP:0002505)1.73738659
82Uterine neoplasm (HP:0010784)1.73725894
83Ovarian neoplasm (HP:0100615)1.71999463
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71946083
85Medial flaring of the eyebrow (HP:0010747)1.71554205
86Stenosis of the external auditory canal (HP:0000402)1.70439458
87Median cleft lip (HP:0000161)1.70288809
88Basal cell carcinoma (HP:0002671)1.69339319
89Molar tooth sign on MRI (HP:0002419)1.68331749
90Abnormality of midbrain morphology (HP:0002418)1.68331749
91Thyroiditis (HP:0100646)1.68201241
92Amyotrophic lateral sclerosis (HP:0007354)1.68077077
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66552890
94Reduced antithrombin III activity (HP:0001976)1.65890397
95Horseshoe kidney (HP:0000085)1.65702623
96Neoplasm of the small intestine (HP:0100833)1.65400240
97Stomach cancer (HP:0012126)1.64362452
98Pancreatic cysts (HP:0001737)1.63741160
99Abnormality of T cell number (HP:0011839)1.61358469
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.59252429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.38817161
2EIF2AK33.46802390
3TRIM283.46050647
4SRPK13.12325607
5BRSK22.85376968
6TSSK62.57682906
7BCR2.47580907
8NEK12.36052948
9ZAK2.27119310
10BUB12.25773474
11PLK42.10947865
12STK162.09840329
13PLK32.05324154
14PBK2.03969174
15TTK2.00850025
16MAP4K21.93129038
17WEE11.90231135
18CDC71.87014641
19SIK31.82428374
20TNIK1.79415398
21NUAK11.73841219
22TAF11.73231968
23WNK31.67986217
24VRK11.66485850
25MKNK11.64873321
26MKNK21.53083520
27ERBB31.48536895
28EIF2AK11.45168728
29ACVR1B1.43153063
30BMPR1B1.36681920
31PLK11.27393731
32CSNK1A1L1.27191234
33VRK21.23968905
34STK31.19421250
35STK241.17562304
36CSNK1G11.14756047
37MAP3K41.14591650
38STK38L1.09704404
39DYRK31.09374308
40MAP2K71.09115725
41BRD41.06432457
42CSNK1G31.05465978
43TXK1.04316153
44MAP3K121.02667214
45BMPR21.01521532
46RPS6KA40.98898787
47CCNB10.98198002
48EIF2AK20.96605523
49MAP3K50.94955605
50BRSK10.92761938
51MARK30.92579366
52CSNK1G20.90098729
53CAMKK20.85679740
54DYRK20.84054359
55PINK10.83136718
56ATR0.81780818
57AURKB0.74864522
58ERBB40.74394194
59PASK0.73219155
60ATM0.72272293
61MAP3K100.70359423
62FRK0.67229533
63STK100.64245242
64PLK20.60316682
65CHEK20.59206360
66TGFBR10.55864391
67IKBKB0.55445434
68YES10.51187737
69IKBKE0.51024335
70GRK70.50900303
71MAP3K140.50061944
72CDK80.48880818
73FGFR10.48552603
74CHEK10.46998630
75MELK0.46547350
76NME10.44232547
77CDK60.43464622
78CDK90.42928347
79FGR0.42903627
80NEK90.42831185
81CLK10.40861439
82TEC0.39700975
83PIM10.39406596
84CDK30.38872945
85ADRBK20.36036926
86EGFR0.34276833
87TLK10.33658916
88CSNK2A10.32481103
89STK40.30914466
90AKT30.30454454
91LATS10.29593844
92DAPK10.28839113
93PKN10.27839586
94NLK0.27224336
95RPS6KA50.27192789
96PIK3CG0.26625062
97CSNK1D0.24066447
98PRKCQ0.22889436
99PAK40.22866305
100CSNK2A20.22619454

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.83864385
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18404567
3Mismatch repair_Homo sapiens_hsa034303.04427912
4Non-homologous end-joining_Homo sapiens_hsa034503.03554871
5Protein export_Homo sapiens_hsa030602.89394790
6Basal transcription factors_Homo sapiens_hsa030222.68094812
7DNA replication_Homo sapiens_hsa030302.64228512
8RNA degradation_Homo sapiens_hsa030182.40835598
9Homologous recombination_Homo sapiens_hsa034402.37249348
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31209215
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.30897263
12RNA transport_Homo sapiens_hsa030132.26466989
13Cell cycle_Homo sapiens_hsa041102.20952735
14Fanconi anemia pathway_Homo sapiens_hsa034602.18617459
15Steroid biosynthesis_Homo sapiens_hsa001002.18082784
16Nucleotide excision repair_Homo sapiens_hsa034202.12309061
17RNA polymerase_Homo sapiens_hsa030201.98523143
18Base excision repair_Homo sapiens_hsa034101.93746308
19Spliceosome_Homo sapiens_hsa030401.92228105
20Folate biosynthesis_Homo sapiens_hsa007901.78634687
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64651057
22Propanoate metabolism_Homo sapiens_hsa006401.60489712
23p53 signaling pathway_Homo sapiens_hsa041151.54910123
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53361198
25Legionellosis_Homo sapiens_hsa051341.48077054
26Regulation of autophagy_Homo sapiens_hsa041401.47675111
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38410344
28Pyrimidine metabolism_Homo sapiens_hsa002401.37677734
29One carbon pool by folate_Homo sapiens_hsa006701.33214718
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26505145
31Epstein-Barr virus infection_Homo sapiens_hsa051691.23549031
32mRNA surveillance pathway_Homo sapiens_hsa030151.20295994
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18656300
34Allograft rejection_Homo sapiens_hsa053301.17872030
35Measles_Homo sapiens_hsa051621.17829412
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16681880
37Systemic lupus erythematosus_Homo sapiens_hsa053221.13835366
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.06988834
39Herpes simplex infection_Homo sapiens_hsa051681.06245979
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03079150
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00402562
42Selenocompound metabolism_Homo sapiens_hsa004500.96037939
43Oocyte meiosis_Homo sapiens_hsa041140.92599199
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92358916
45Rheumatoid arthritis_Homo sapiens_hsa053230.92342411
46Purine metabolism_Homo sapiens_hsa002300.83719879
47Viral carcinogenesis_Homo sapiens_hsa052030.82939424
48Graft-versus-host disease_Homo sapiens_hsa053320.82864027
49Primary immunodeficiency_Homo sapiens_hsa053400.79771795
50Pyruvate metabolism_Homo sapiens_hsa006200.78756541
51Circadian rhythm_Homo sapiens_hsa047100.76523771
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75971559
53Type I diabetes mellitus_Homo sapiens_hsa049400.75851064
54Asthma_Homo sapiens_hsa053100.74101461
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.72889009
56Shigellosis_Homo sapiens_hsa051310.72666722
57Fatty acid elongation_Homo sapiens_hsa000620.71834151
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71706435
59Influenza A_Homo sapiens_hsa051640.71530116
60Autoimmune thyroid disease_Homo sapiens_hsa053200.71311443
61TGF-beta signaling pathway_Homo sapiens_hsa043500.70123815
62Caffeine metabolism_Homo sapiens_hsa002320.69293413
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68618155
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67347098
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67319364
66Hepatitis B_Homo sapiens_hsa051610.65471042
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65010395
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62697972
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61338474
70Apoptosis_Homo sapiens_hsa042100.55719647
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50947382
72Alcoholism_Homo sapiens_hsa050340.49729271
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.49253193
74Antigen processing and presentation_Homo sapiens_hsa046120.48809085
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.48653227
76African trypanosomiasis_Homo sapiens_hsa051430.48642996
77Salmonella infection_Homo sapiens_hsa051320.46592193
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44305032
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43480612
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41673330
81Carbon metabolism_Homo sapiens_hsa012000.40394460
82Malaria_Homo sapiens_hsa051440.39332687
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38424185
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37854532
85Oxidative phosphorylation_Homo sapiens_hsa001900.36695318
86T cell receptor signaling pathway_Homo sapiens_hsa046600.36175457
87Viral myocarditis_Homo sapiens_hsa054160.35699561
88Leishmaniasis_Homo sapiens_hsa051400.34789268
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33891657
90Parkinsons disease_Homo sapiens_hsa050120.33446541
91Hematopoietic cell lineage_Homo sapiens_hsa046400.33351351
92TNF signaling pathway_Homo sapiens_hsa046680.30678040
93Phototransduction_Homo sapiens_hsa047440.30479339
94Peroxisome_Homo sapiens_hsa041460.29807744
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29804544
96Colorectal cancer_Homo sapiens_hsa052100.29489302
97Tuberculosis_Homo sapiens_hsa051520.28811568
98Biosynthesis of amino acids_Homo sapiens_hsa012300.27687525
99Huntingtons disease_Homo sapiens_hsa050160.27511703
100HTLV-I infection_Homo sapiens_hsa051660.27319234

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