C3ORF62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)3.96832892
2negative regulation of cell killing (GO:0031342)3.92825809
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92825809
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87267514
5DNA deamination (GO:0045006)3.81446119
6negative regulation of interleukin-1 beta production (GO:0032691)3.80464768
7behavioral response to nicotine (GO:0035095)3.75325687
8adaptation of signaling pathway (GO:0023058)3.73395251
9negative regulation of interleukin-1 production (GO:0032692)3.67671849
10activated T cell proliferation (GO:0050798)3.64449856
11regulation of B cell receptor signaling pathway (GO:0050855)3.48170622
12sulfation (GO:0051923)3.42460598
13positive regulation of gamma-delta T cell activation (GO:0046645)3.33769169
14cellular response to interleukin-15 (GO:0071350)3.33693876
15fucose catabolic process (GO:0019317)3.30027046
16L-fucose metabolic process (GO:0042354)3.30027046
17L-fucose catabolic process (GO:0042355)3.30027046
18positive regulation of mast cell activation (GO:0033005)3.24251230
19cellular extravasation (GO:0045123)3.18432229
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15241537
21negative regulation of mast cell activation (GO:0033004)3.10907058
22negative regulation of protein oligomerization (GO:0032460)3.10253565
23neural tube formation (GO:0001841)3.06538296
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.05165806
25modulation by symbiont of host immune response (GO:0052553)3.05165806
26positive regulation by symbiont of host defense response (GO:0052509)3.05165806
27modulation by symbiont of host defense response (GO:0052031)3.05165806
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05165806
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05165806
30macrophage activation involved in immune response (GO:0002281)2.99896048
31positive regulation of defense response to virus by host (GO:0002230)2.99418081
32protein K11-linked deubiquitination (GO:0035871)2.97581162
33regulation of memory T cell differentiation (GO:0043380)2.97337051
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94279231
35interferon-gamma production (GO:0032609)2.94148691
36regulation of mast cell activation (GO:0033003)2.92479600
37response to interleukin-15 (GO:0070672)2.87232821
38indole-containing compound catabolic process (GO:0042436)2.86811277
39indolalkylamine catabolic process (GO:0046218)2.86811277
40tryptophan catabolic process (GO:0006569)2.86811277
41antigen processing and presentation of endogenous antigen (GO:0019883)2.84733587
42negative regulation of telomere maintenance (GO:0032205)2.84197245
43platelet dense granule organization (GO:0060155)2.80221664
44regulation of gamma-delta T cell activation (GO:0046643)2.77342696
45tolerance induction (GO:0002507)2.76583603
46positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75705975
47negative regulation of interleukin-12 production (GO:0032695)2.75429472
48neutrophil mediated immunity (GO:0002446)2.73686506
49neutrophil activation (GO:0042119)2.73184880
50negative regulation of lymphocyte mediated immunity (GO:0002707)2.72788244
51positive regulation of mast cell activation involved in immune response (GO:0033008)2.68464943
52positive regulation of mast cell degranulation (GO:0043306)2.68464943
53neutrophil activation involved in immune response (GO:0002283)2.68213483
54regulation of T cell mediated cytotoxicity (GO:0001914)2.67664986
55regulation of gamma-delta T cell differentiation (GO:0045586)2.67067563
56detection of light stimulus involved in visual perception (GO:0050908)2.64707168
57detection of light stimulus involved in sensory perception (GO:0050962)2.64707168
58macrophage activation (GO:0042116)2.64509750
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62358320
60regulation of germinal center formation (GO:0002634)2.59972742
61indolalkylamine metabolic process (GO:0006586)2.59526755
62rRNA catabolic process (GO:0016075)2.59387454
63cell wall macromolecule catabolic process (GO:0016998)2.56445147
64cilium or flagellum-dependent cell motility (GO:0001539)2.55230639
65negative regulation of T cell mediated immunity (GO:0002710)2.51523105
66regulation of interleukin-6 biosynthetic process (GO:0045408)2.51353659
67myeloid leukocyte mediated immunity (GO:0002444)2.50911248
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50668365
69tryptophan metabolic process (GO:0006568)2.50486169
70cell wall macromolecule metabolic process (GO:0044036)2.50143342
71cellular biogenic amine catabolic process (GO:0042402)2.48742511
72amine catabolic process (GO:0009310)2.48742511
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45404303
74positive regulation of antigen processing and presentation (GO:0002579)2.44644759
75epithelial cilium movement (GO:0003351)2.43901782
76cytidine catabolic process (GO:0006216)2.43890479
77cytidine deamination (GO:0009972)2.43890479
78cytidine metabolic process (GO:0046087)2.43890479
79kynurenine metabolic process (GO:0070189)2.43529030
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42906256
81negative regulation of cAMP-mediated signaling (GO:0043951)2.42668458
82axoneme assembly (GO:0035082)2.41914400
83piRNA metabolic process (GO:0034587)2.40815763
84myeloid cell activation involved in immune response (GO:0002275)2.39519536
85antigen processing and presentation via MHC class Ib (GO:0002475)2.38768271
86multicellular organism reproduction (GO:0032504)2.38562532
87phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38497530
88mast cell activation (GO:0045576)2.38362835
89positive regulation of T-helper 1 type immune response (GO:0002827)2.36089220
90granulocyte activation (GO:0036230)2.33849614
91establishment of protein localization to Golgi (GO:0072600)2.32503007
92negative T cell selection (GO:0043383)2.30919031
93response to pheromone (GO:0019236)2.30673086
94T-helper 1 type immune response (GO:0042088)2.30596625
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.29122058
96negative regulation of T-helper cell differentiation (GO:0045623)2.29122058
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.27534941
98mast cell activation involved in immune response (GO:0002279)2.27327955
99mast cell degranulation (GO:0043303)2.27327955
100negative regulation of interleukin-6 production (GO:0032715)2.26704929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.55075410
2ZNF274_21170338_ChIP-Seq_K562_Hela3.33210259
3EZH2_22144423_ChIP-Seq_EOC_Human2.91152071
4VDR_22108803_ChIP-Seq_LS180_Human2.64252091
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50097206
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.37631531
7GBX2_23144817_ChIP-Seq_PC3_Human2.29863567
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22074697
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07209240
10IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93063001
11IRF1_19129219_ChIP-ChIP_H3396_Human1.88516834
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87953913
13IGF1R_20145208_ChIP-Seq_DFB_Human1.83255159
14NOTCH1_21737748_ChIP-Seq_TLL_Human1.82635067
15ER_23166858_ChIP-Seq_MCF-7_Human1.78130200
16RUNX_20019798_ChIP-Seq_JUKART_Human1.72270292
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69009478
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67375991
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65483773
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65358097
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63277990
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58203839
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58203839
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57280165
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.56767529
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55214149
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53807474
28BCAT_22108803_ChIP-Seq_LS180_Human1.49448895
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45596722
30TAF15_26573619_Chip-Seq_HEK293_Human1.44025031
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41712449
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40873855
33P300_19829295_ChIP-Seq_ESCs_Human1.40513993
34GATA3_26560356_Chip-Seq_TH2_Human1.39967466
35REST_21632747_ChIP-Seq_MESCs_Mouse1.37372709
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34750490
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32527252
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30922421
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.28178136
40TP53_22573176_ChIP-Seq_HFKS_Human1.28026885
41STAT3_23295773_ChIP-Seq_U87_Human1.27716838
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.27647905
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27284124
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26486387
45AR_21572438_ChIP-Seq_LNCaP_Human1.25523983
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.25293691
47DROSHA_22980978_ChIP-Seq_HELA_Human1.24853500
48SCL_19346495_ChIP-Seq_HPC-7_Human1.24679743
49* VDR_24787735_ChIP-Seq_THP-1_Human1.22938470
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21011462
51GATA1_22025678_ChIP-Seq_K562_Human1.20954783
52FUS_26573619_Chip-Seq_HEK293_Human1.20373076
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18608021
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.18608021
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18053549
56AR_25329375_ChIP-Seq_VCAP_Human1.17751324
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16949105
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16273514
59EWS_26573619_Chip-Seq_HEK293_Human1.15812711
60TCF4_23295773_ChIP-Seq_U87_Human1.13764716
61SMRT_27268052_Chip-Seq_Bcells_Human1.11785228
62GATA3_27048872_Chip-Seq_THYMUS_Human1.11556358
63SOX2_19829295_ChIP-Seq_ESCs_Human1.10802033
64NANOG_19829295_ChIP-Seq_ESCs_Human1.10802033
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10693633
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08682575
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06985175
68CBP_20019798_ChIP-Seq_JUKART_Human1.06985175
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06832321
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06651752
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06230137
72SMAD4_21799915_ChIP-Seq_A2780_Human1.05908056
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05850695
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02945270
75NANOG_20526341_ChIP-Seq_ESCs_Human1.02820105
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02204116
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02002815
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01380546
79MYB_26560356_Chip-Seq_TH2_Human1.01291230
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01085621
81RUNX2_22187159_ChIP-Seq_PCA_Human1.00667853
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.00185327
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.99819398
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99775373
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99436150
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98979061
87FLI1_21867929_ChIP-Seq_TH2_Mouse0.98949000
88CBX2_27304074_Chip-Seq_ESCs_Mouse0.98936013
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97889480
90AR_20517297_ChIP-Seq_VCAP_Human0.97842500
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97513794
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96636141
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95826612
94TCF4_22108803_ChIP-Seq_LS180_Human0.95325493
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.94884219
96NCOR_22424771_ChIP-Seq_293T_Human0.94315663
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91747837
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.91517176
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.91218566
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91023540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.15031807
2MP0005671_abnormal_response_to2.64403878
3MP0006082_CNS_inflammation2.61424115
4MP0000569_abnormal_digit_pigmentation2.56883910
5MP0003011_delayed_dark_adaptation2.47324024
6MP0008877_abnormal_DNA_methylation2.27491467
7MP0003195_calcinosis2.17517353
8MP0001835_abnormal_antigen_presentation2.12238429
9MP0003787_abnormal_imprinting2.10077787
10MP0001800_abnormal_humoral_immune2.05404911
11MP0001986_abnormal_taste_sensitivity1.92619005
12MP0002277_abnormal_respiratory_mucosa1.87131459
13MP0009785_altered_susceptibility_to1.86992570
14MP0005000_abnormal_immune_tolerance1.83373605
15MP0005551_abnormal_eye_electrophysiolog1.80210696
16MP0002419_abnormal_innate_immunity1.77572847
17MP0002723_abnormal_immune_serum1.77058785
18MP0003436_decreased_susceptibility_to1.74990492
19MP0005387_immune_system_phenotype1.74686850
20MP0001790_abnormal_immune_system1.74686850
21MP0000685_abnormal_immune_system1.74245275
22MP0002254_reproductive_system_inflammat1.73027431
23MP0001968_abnormal_touch/_nociception1.71654487
24MP0002102_abnormal_ear_morphology1.67132664
25MP0002876_abnormal_thyroid_physiology1.66535873
26MP0009764_decreased_sensitivity_to1.65756305
27MP0002452_abnormal_antigen_presenting1.65452926
28MP0005310_abnormal_salivary_gland1.60200273
29MP0003183_abnormal_peptide_metabolism1.60120474
30MP0005167_abnormal_blood-brain_barrier1.58618193
31MP0002420_abnormal_adaptive_immunity1.57551323
32MP0002148_abnormal_hypersensitivity_rea1.57529199
33MP0005025_abnormal_response_to1.57202003
34MP0002653_abnormal_ependyma_morphology1.54837131
35MP0001819_abnormal_immune_cell1.54374411
36MP0003646_muscle_fatigue1.52610768
37MP0002837_dystrophic_cardiac_calcinosis1.46767909
38MP0002638_abnormal_pupillary_reflex1.39603721
39MP0005075_abnormal_melanosome_morpholog1.39219093
40MP0001501_abnormal_sleep_pattern1.38370862
41MP0002405_respiratory_system_inflammati1.38051559
42MP0005174_abnormal_tail_pigmentation1.35749247
43MP0002163_abnormal_gland_morphology1.35217286
44MP0002132_abnormal_respiratory_system1.35137627
45MP0002928_abnormal_bile_duct1.32970034
46MP0005377_hearing/vestibular/ear_phenot1.29097221
47MP0003878_abnormal_ear_physiology1.29097221
48MP0004742_abnormal_vestibular_system1.28148348
49MP0004885_abnormal_endolymph1.26323361
50MP0009745_abnormal_behavioral_response1.25982317
51MP0004043_abnormal_pH_regulation1.21235515
52MP0004142_abnormal_muscle_tone1.18384390
53MP0008875_abnormal_xenobiotic_pharmacok1.18202186
54MP0003303_peritoneal_inflammation1.17369275
55MP0003763_abnormal_thymus_physiology1.17050469
56MP0006276_abnormal_autonomic_nervous1.16527312
57MP0003880_abnormal_central_pattern1.16271855
58MP0001873_stomach_inflammation1.15850140
59MP0005645_abnormal_hypothalamus_physiol1.15612246
60MP0001919_abnormal_reproductive_system1.15541879
61MP0001486_abnormal_startle_reflex1.14883436
62MP0002736_abnormal_nociception_after1.14787639
63MP0005084_abnormal_gallbladder_morpholo1.14268711
64MP0008872_abnormal_physiological_respon1.14018876
65MP0005253_abnormal_eye_physiology1.10511043
66MP0005389_reproductive_system_phenotype1.09892262
67MP0000716_abnormal_immune_system1.09482980
68MP0000015_abnormal_ear_pigmentation1.08619577
69MP0004130_abnormal_muscle_cell1.07289951
70MP0004381_abnormal_hair_follicle1.06142018
71MP0001845_abnormal_inflammatory_respons1.05735749
72MP0000372_irregular_coat_pigmentation1.04952341
73MP0002272_abnormal_nervous_system1.04687754
74MP0005646_abnormal_pituitary_gland0.98735893
75MP0009046_muscle_twitch0.98149474
76MP0001970_abnormal_pain_threshold0.98018606
77MP0001663_abnormal_digestive_system0.97732572
78MP0002693_abnormal_pancreas_physiology0.96043513
79MP0002733_abnormal_thermal_nociception0.93805660
80MP0001533_abnormal_skeleton_physiology0.92675948
81MP0008469_abnormal_protein_level0.92363427
82MP0002735_abnormal_chemical_nociception0.91527604
83MP0003136_yellow_coat_color0.91203981
84MP0005379_endocrine/exocrine_gland_phen0.90369264
85MP0002398_abnormal_bone_marrow0.89668735
86MP0000689_abnormal_spleen_morphology0.88762960
87MP0000427_abnormal_hair_cycle0.88207246
88MP0003252_abnormal_bile_duct0.87148168
89MP0002064_seizures0.87007928
90MP0003866_abnormal_defecation0.86982858
91MP0009333_abnormal_splenocyte_physiolog0.86400723
92MP0002095_abnormal_skin_pigmentation0.86284669
93MP0002067_abnormal_sensory_capabilities0.83429665
94MP0002138_abnormal_hepatobiliary_system0.83392598
95MP0006292_abnormal_olfactory_placode0.83024917
96MP0000230_abnormal_systemic_arterial0.82130467
97MP0004883_abnormal_blood_vessel0.82076418
98MP0005410_abnormal_fertilization0.81015041
99MP0001485_abnormal_pinna_reflex0.78921451
100MP0003172_abnormal_lysosome_physiology0.77987928

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.30524897
2Elevated erythrocyte sedimentation rate (HP:0003565)4.28039792
3Retrobulbar optic neuritis (HP:0100654)3.86664406
4Optic neuritis (HP:0100653)3.86664406
5Pancreatic cysts (HP:0001737)3.68384181
6Congenital stationary night blindness (HP:0007642)3.63251601
7Myositis (HP:0100614)3.56266845
8Orchitis (HP:0100796)3.48792681
9True hermaphroditism (HP:0010459)3.28180966
10Pancreatic fibrosis (HP:0100732)3.24488945
11Keratoconjunctivitis (HP:0001096)3.09212914
12Hyperventilation (HP:0002883)3.09187983
13Chronic mucocutaneous candidiasis (HP:0002728)3.03075476
14Recurrent cutaneous fungal infections (HP:0011370)3.03075476
15Molar tooth sign on MRI (HP:0002419)3.02601318
16Abnormality of midbrain morphology (HP:0002418)3.02601318
17Type II lissencephaly (HP:0007260)2.87542010
18Recurrent fungal infections (HP:0002841)2.79822729
19Stomach cancer (HP:0012126)2.75582657
20Abnormal delayed hypersensitivity skin test (HP:0002963)2.74782503
21Attenuation of retinal blood vessels (HP:0007843)2.73720664
22Hypochromic microcytic anemia (HP:0004840)2.71549912
23Nephronophthisis (HP:0000090)2.66878309
24Progressive cerebellar ataxia (HP:0002073)2.65678269
25Gastrointestinal infarctions (HP:0005244)2.63655936
26Abnormal drinking behavior (HP:0030082)2.57325245
27Polydipsia (HP:0001959)2.57325245
28Abnormal rod and cone electroretinograms (HP:0008323)2.54258511
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53158790
30Hypochromic anemia (HP:0001931)2.51967950
31Abnormality of the renal cortex (HP:0011035)2.51194712
32Encephalitis (HP:0002383)2.49983452
33Keratoconjunctivitis sicca (HP:0001097)2.46167822
34Abolished electroretinogram (ERG) (HP:0000550)2.46016285
35Abnormality of the renal medulla (HP:0100957)2.45484187
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45181427
37Hemoptysis (HP:0002105)2.44898383
38Medial flaring of the eyebrow (HP:0010747)2.37265844
39Genetic anticipation (HP:0003743)2.37153646
40Recurrent bacterial skin infections (HP:0005406)2.34662404
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.23849446
42Absent/shortened dynein arms (HP:0200106)2.23849446
43Agitation (HP:0000713)2.23106703
44Recurrent abscess formation (HP:0002722)2.19370145
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.18995553
46Abnormality of T cell number (HP:0011839)2.18490308
47Protruding tongue (HP:0010808)2.14020234
48Asplenia (HP:0001746)2.13570665
49Cystic liver disease (HP:0006706)2.12383277
50Vasculitis (HP:0002633)2.12072599
51Recurrent skin infections (HP:0001581)2.11417933
52Clumsiness (HP:0002312)2.11093461
53Pulmonary infiltrates (HP:0002113)2.10818876
54Polyuria (HP:0000103)2.09200502
55Abnormality of T cells (HP:0002843)2.07416700
56Absent speech (HP:0001344)2.04274389
57Pendular nystagmus (HP:0012043)2.04274278
58Decreased central vision (HP:0007663)2.00823205
59Pustule (HP:0200039)2.00605209
60Leukocytosis (HP:0001974)2.00421980
61Febrile seizures (HP:0002373)1.99004604
62Lissencephaly (HP:0001339)1.96489815
63Anorexia (HP:0002039)1.95686064
64Chronic hepatic failure (HP:0100626)1.95369809
65Congenital sensorineural hearing impairment (HP:0008527)1.93830353
66T lymphocytopenia (HP:0005403)1.93640298
67Thyroiditis (HP:0100646)1.93235451
68Gaze-evoked nystagmus (HP:0000640)1.90805895
69Abnormality of T cell physiology (HP:0011840)1.90774814
70Autoimmune thrombocytopenia (HP:0001973)1.90037480
71Mediastinal lymphadenopathy (HP:0100721)1.88321553
72Keratitis (HP:0000491)1.87213286
73Polyphagia (HP:0002591)1.86659953
74Tubular atrophy (HP:0000092)1.86509869
75Abnormality of eosinophils (HP:0001879)1.83999649
76Gait imbalance (HP:0002141)1.83826802
77Meningitis (HP:0001287)1.82987136
78Furrowed tongue (HP:0000221)1.80844899
79Abnormal ciliary motility (HP:0012262)1.80748632
80Abnormality of B cell number (HP:0010975)1.80069218
81Chronic obstructive pulmonary disease (HP:0006510)1.79013416
82Obstructive lung disease (HP:0006536)1.79013416
83Hemiplegia (HP:0002301)1.78438044
84Inability to walk (HP:0002540)1.76658290
85Macroglossia (HP:0000158)1.75390685
86Abnormal respiratory epithelium morphology (HP:0012253)1.74317307
87Abnormal respiratory motile cilium morphology (HP:0005938)1.74317307
88Congenital primary aphakia (HP:0007707)1.73376614
89Episodic fever (HP:0001954)1.72585286
90Peritonitis (HP:0002586)1.72197544
91Congenital hepatic fibrosis (HP:0002612)1.71808743
92Anencephaly (HP:0002323)1.70968018
93Chest pain (HP:0100749)1.70590866
94Cheilitis (HP:0100825)1.70570480
95Neoplasm of the adrenal cortex (HP:0100641)1.70481855
96IgG deficiency (HP:0004315)1.69913159
97Severe combined immunodeficiency (HP:0004430)1.68774728
98Male pseudohermaphroditism (HP:0000037)1.67945590
99Nephrogenic diabetes insipidus (HP:0009806)1.67862587
100Bony spicule pigmentary retinopathy (HP:0007737)1.67402295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.68604465
2TAOK33.34457662
3TXK3.28515873
4ADRBK22.71867284
5ACVR1B2.39064784
6BLK2.29929542
7BMPR1B2.05863292
8MAP4K11.98867712
9TNK21.91535135
10CAMKK21.86652048
11NUAK11.86600443
12DAPK21.74249398
13IRAK41.72891443
14MAPK131.72573041
15RIPK41.66671430
16WNK41.61676086
17WNK31.54373374
18PINK11.53457990
19GRK11.51428816
20GRK71.48169224
21IKBKB1.47705128
22CSK1.47547343
23SYK1.46281868
24MAP3K141.42121422
25GRK61.42065758
26IKBKE1.36097840
27FES1.35738258
28MAP4K21.30527194
29CAMKK11.29449842
30TEC1.28750612
31INSRR1.28648956
32TLK11.25346890
33KIT1.24033602
34ADRBK11.22117031
35IRAK11.19064086
36ITK1.18742939
37OXSR11.18371871
38PTK2B1.16991696
39LYN1.13932174
40ZAK1.05401749
41PRKCQ1.00934060
42KDR1.00508461
43PAK31.00155418
44FGR0.97124697
45BTK0.94580329
46STK110.89106933
47TYK20.87039429
48LCK0.84621254
49CAMK1D0.83772200
50MAP2K60.82284270
51CSF1R0.81827256
52SIK20.81136236
53CASK0.80439701
54MARK30.77995309
55MAP2K40.76650102
56TGFBR20.75997506
57GRK50.75981898
58STK390.74485717
59HIPK20.74279214
60MAP3K110.72066453
61MATK0.70406897
62NTRK30.69221939
63HCK0.68773167
64ZAP700.67590124
65MAP3K70.66665668
66MAP2K20.64437475
67MAPK150.64231324
68CHUK0.63661499
69JAK20.62887690
70PASK0.62494820
71MARK20.62167756
72IRAK20.61924358
73MAP3K40.61904506
74CAMK10.60515668
75PIK3CG0.57619143
76MAP3K130.55064894
77PRKAA20.54097294
78JAK10.53750618
79BMPR20.53536899
80PRKCZ0.53477022
81PRKCG0.51908465
82CAMK40.51329786
83JAK30.51197399
84RPS6KA60.50416376
85TBK10.49852749
86SGK20.48400126
87DYRK20.48106810
88PKN10.47887769
89TGFBR10.46829774
90MAP2K30.44699710
91PRKD20.43187566
92PDK10.43168069
93DYRK1A0.42331217
94EPHB10.41584453
95PIK3CA0.40738817
96PRKCH0.40431264
97ABL10.39393514
98PRKCE0.38860369
99SGK10.36919798
100NTRK20.36590737

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38797352
2Primary immunodeficiency_Homo sapiens_hsa053402.31867604
3Graft-versus-host disease_Homo sapiens_hsa053322.25398695
4Phototransduction_Homo sapiens_hsa047442.24930665
5Linoleic acid metabolism_Homo sapiens_hsa005912.24372829
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18766795
7Allograft rejection_Homo sapiens_hsa053302.13636093
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.06439229
9Staphylococcus aureus infection_Homo sapiens_hsa051502.04173823
10Autoimmune thyroid disease_Homo sapiens_hsa053201.99928607
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94082588
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92225758
13Type I diabetes mellitus_Homo sapiens_hsa049401.80874270
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79587252
15Nitrogen metabolism_Homo sapiens_hsa009101.75776558
16Asthma_Homo sapiens_hsa053101.71299441
17Leishmaniasis_Homo sapiens_hsa051401.68382151
18Osteoclast differentiation_Homo sapiens_hsa043801.64725571
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57686854
20Ether lipid metabolism_Homo sapiens_hsa005651.56413166
21Morphine addiction_Homo sapiens_hsa050321.45569781
22Nicotine addiction_Homo sapiens_hsa050331.42030392
23Regulation of autophagy_Homo sapiens_hsa041401.34775779
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31893792
25Hematopoietic cell lineage_Homo sapiens_hsa046401.29842435
26Dorso-ventral axis formation_Homo sapiens_hsa043201.28693649
27Rheumatoid arthritis_Homo sapiens_hsa053231.26978626
28Tuberculosis_Homo sapiens_hsa051521.26446287
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25974412
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23175251
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.22027092
32T cell receptor signaling pathway_Homo sapiens_hsa046601.19320553
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17899404
34Olfactory transduction_Homo sapiens_hsa047401.16693871
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15420602
36Antigen processing and presentation_Homo sapiens_hsa046121.14229937
37Ovarian steroidogenesis_Homo sapiens_hsa049131.11507856
38Arachidonic acid metabolism_Homo sapiens_hsa005901.09521476
39Chemokine signaling pathway_Homo sapiens_hsa040621.07068245
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06971607
41ABC transporters_Homo sapiens_hsa020101.06872153
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.06498348
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03615018
44Collecting duct acid secretion_Homo sapiens_hsa049661.01825097
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.00925307
46Taste transduction_Homo sapiens_hsa047421.00105298
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99387187
48B cell receptor signaling pathway_Homo sapiens_hsa046620.98701457
49African trypanosomiasis_Homo sapiens_hsa051430.96433395
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94537244
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94492059
52Malaria_Homo sapiens_hsa051440.92961948
53Caffeine metabolism_Homo sapiens_hsa002320.92790582
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90324982
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87247516
56Butanoate metabolism_Homo sapiens_hsa006500.87213845
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86137616
58Serotonergic synapse_Homo sapiens_hsa047260.85252040
59Glutamatergic synapse_Homo sapiens_hsa047240.82827391
60Circadian entrainment_Homo sapiens_hsa047130.82309220
61Oxidative phosphorylation_Homo sapiens_hsa001900.81114382
62GABAergic synapse_Homo sapiens_hsa047270.80015844
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77852414
64Legionellosis_Homo sapiens_hsa051340.77597638
65Selenocompound metabolism_Homo sapiens_hsa004500.74721455
66Measles_Homo sapiens_hsa051620.72917379
67Platelet activation_Homo sapiens_hsa046110.70969479
68Insulin secretion_Homo sapiens_hsa049110.70746958
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69960197
70Peroxisome_Homo sapiens_hsa041460.69215033
71Tryptophan metabolism_Homo sapiens_hsa003800.68998933
72Chemical carcinogenesis_Homo sapiens_hsa052040.67759147
73TNF signaling pathway_Homo sapiens_hsa046680.67248529
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66254311
75Phagosome_Homo sapiens_hsa041450.62259798
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.59401701
77Calcium signaling pathway_Homo sapiens_hsa040200.59142311
78cAMP signaling pathway_Homo sapiens_hsa040240.57676656
79Cholinergic synapse_Homo sapiens_hsa047250.57400108
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.56647654
81Glycerolipid metabolism_Homo sapiens_hsa005610.56518527
82Oxytocin signaling pathway_Homo sapiens_hsa049210.56075472
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55795187
84Salivary secretion_Homo sapiens_hsa049700.54884355
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54543634
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54060472
87Homologous recombination_Homo sapiens_hsa034400.53659916
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53516470
89Influenza A_Homo sapiens_hsa051640.52695950
90Toxoplasmosis_Homo sapiens_hsa051450.52671334
91Fanconi anemia pathway_Homo sapiens_hsa034600.52180153
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51664854
93MAPK signaling pathway_Homo sapiens_hsa040100.51475686
94Lysosome_Homo sapiens_hsa041420.51215067
95Mineral absorption_Homo sapiens_hsa049780.50908645
96Long-term depression_Homo sapiens_hsa047300.47662761
97Retinol metabolism_Homo sapiens_hsa008300.47094231
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.46994618
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46489489
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45506632

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