C3ORF67

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.56509140
2epithelial cilium movement (GO:0003351)4.47253756
3synapsis (GO:0007129)4.33495830
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.17117976
5axonemal dynein complex assembly (GO:0070286)4.10056195
6behavioral response to nicotine (GO:0035095)4.06679366
7cilium movement (GO:0003341)4.04980984
8DNA methylation involved in gamete generation (GO:0043046)3.86794455
9negative regulation of cytosolic calcium ion concentration (GO:0051481)3.76678836
10sperm motility (GO:0030317)3.61074409
11regulation of cilium movement (GO:0003352)3.59652833
12protein polyglutamylation (GO:0018095)3.59640687
13cilium or flagellum-dependent cell motility (GO:0001539)3.59594352
14male meiosis (GO:0007140)3.52933345
15response to pheromone (GO:0019236)3.48951426
16male meiosis I (GO:0007141)3.42882312
17resolution of meiotic recombination intermediates (GO:0000712)3.42437704
18behavioral response to ethanol (GO:0048149)3.42276092
19chromosome organization involved in meiosis (GO:0070192)3.41106237
20regulation of acrosome reaction (GO:0060046)3.37258689
21regulation of meiosis I (GO:0060631)3.36675992
22acrosome reaction (GO:0007340)3.34485463
23cellular ketone body metabolic process (GO:0046950)3.32515343
24motile cilium assembly (GO:0044458)3.31701760
25multicellular organism reproduction (GO:0032504)3.27311521
26meiotic chromosome segregation (GO:0045132)3.21294128
27fucose catabolic process (GO:0019317)3.17175576
28L-fucose metabolic process (GO:0042354)3.17175576
29L-fucose catabolic process (GO:0042355)3.17175576
30spermatid development (GO:0007286)3.14900976
31replication fork processing (GO:0031297)3.11873647
32microtubule depolymerization (GO:0007019)3.02355170
33protein localization to cilium (GO:0061512)3.01910980
34cilium morphogenesis (GO:0060271)3.01829482
35axoneme assembly (GO:0035082)2.97829935
36intraciliary transport (GO:0042073)2.97162070
37reciprocal meiotic recombination (GO:0007131)2.97157835
38reciprocal DNA recombination (GO:0035825)2.97157835
39cilium organization (GO:0044782)2.93156175
40proteasome assembly (GO:0043248)2.92374904
41ketone body metabolic process (GO:1902224)2.92325161
42cilium assembly (GO:0042384)2.86578325
43single strand break repair (GO:0000012)2.86286806
44DNA double-strand break processing (GO:0000729)2.86251141
45detection of light stimulus involved in visual perception (GO:0050908)2.86118989
46detection of light stimulus involved in sensory perception (GO:0050962)2.86118989
47meiosis I (GO:0007127)2.84808379
48photoreceptor cell maintenance (GO:0045494)2.84316004
49adult feeding behavior (GO:0008343)2.82426953
50protein K6-linked ubiquitination (GO:0085020)2.81904042
51sperm-egg recognition (GO:0035036)2.81429163
52nonmotile primary cilium assembly (GO:0035058)2.77283396
53regulation of microtubule-based movement (GO:0060632)2.75351593
54left/right axis specification (GO:0070986)2.74362367
55preassembly of GPI anchor in ER membrane (GO:0016254)2.70697053
56centriole replication (GO:0007099)2.70647737
57recombinational repair (GO:0000725)2.69030909
58somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67513965
59somatic hypermutation of immunoglobulin genes (GO:0016446)2.67513965
60double-strand break repair via homologous recombination (GO:0000724)2.67163879
61ncRNA catabolic process (GO:0034661)2.64911613
62protein complex biogenesis (GO:0070271)2.64469362
63somite rostral/caudal axis specification (GO:0032525)2.63027163
64microtubule polymerization or depolymerization (GO:0031109)2.61528835
65peptidyl-histidine modification (GO:0018202)2.60317954
66mitochondrial respiratory chain complex assembly (GO:0033108)2.60199020
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.58755579
68meiotic nuclear division (GO:0007126)2.58319565
69retinal cone cell development (GO:0046549)2.57903665
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55707765
71respiratory chain complex IV assembly (GO:0008535)2.55278849
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54919100
73meiotic cell cycle (GO:0051321)2.54568871
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54213560
75meiotic cell cycle process (GO:1903046)2.53302236
76cornea development in camera-type eye (GO:0061303)2.48540463
77water-soluble vitamin biosynthetic process (GO:0042364)2.46294785
78regulation of hexokinase activity (GO:1903299)2.46221623
79regulation of glucokinase activity (GO:0033131)2.46221623
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.44536965
81mannosylation (GO:0097502)2.44026124
82rRNA catabolic process (GO:0016075)2.43957961
83indolalkylamine metabolic process (GO:0006586)2.43166265
84positive regulation of meiosis (GO:0045836)2.41703544
85positive regulation of cAMP-mediated signaling (GO:0043950)2.40459559
86tryptophan catabolic process (GO:0006569)2.40116081
87indole-containing compound catabolic process (GO:0042436)2.40116081
88indolalkylamine catabolic process (GO:0046218)2.40116081
89negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.39599599
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.39123609
91regulation of mesoderm development (GO:2000380)2.39000674
92platelet dense granule organization (GO:0060155)2.36983109
93centriole assembly (GO:0098534)2.36438555
94rRNA modification (GO:0000154)2.36281808
95DNA replication-dependent nucleosome assembly (GO:0006335)2.35687841
96DNA replication-dependent nucleosome organization (GO:0034723)2.35687841
97regulation of DNA endoreduplication (GO:0032875)2.35557353
98synaptonemal complex assembly (GO:0007130)2.35518028
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.33535993
100NADH dehydrogenase complex assembly (GO:0010257)2.33535993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.42807502
2VDR_22108803_ChIP-Seq_LS180_Human3.34252020
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64535056
4GBX2_23144817_ChIP-Seq_PC3_Human2.61747733
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46207569
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42450428
7* FUS_26573619_Chip-Seq_HEK293_Human2.35612221
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34250925
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27193083
10* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24861780
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.24067113
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22145440
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18993344
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15389313
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.13187640
16EWS_26573619_Chip-Seq_HEK293_Human2.04918897
17IGF1R_20145208_ChIP-Seq_DFB_Human1.97699619
18P300_19829295_ChIP-Seq_ESCs_Human1.97138864
19TAF15_26573619_Chip-Seq_HEK293_Human1.96052061
20* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94542338
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87262483
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.85436358
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.85002230
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76875310
25ER_23166858_ChIP-Seq_MCF-7_Human1.72080576
26EZH2_22144423_ChIP-Seq_EOC_Human1.65274160
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62538005
28IRF1_19129219_ChIP-ChIP_H3396_Human1.61786351
29* CBP_20019798_ChIP-Seq_JUKART_Human1.60712458
30* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60712458
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57934072
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56263604
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55727307
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55727307
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54152097
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52934051
37MYC_18940864_ChIP-ChIP_HL60_Human1.50723200
38TP53_22573176_ChIP-Seq_HFKS_Human1.49371986
39SMAD4_21799915_ChIP-Seq_A2780_Human1.49231125
40* STAT3_23295773_ChIP-Seq_U87_Human1.49092428
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47301382
42* BCAT_22108803_ChIP-Seq_LS180_Human1.46001394
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44640277
44AR_25329375_ChIP-Seq_VCAP_Human1.44119276
45ELK1_19687146_ChIP-ChIP_HELA_Human1.40889860
46NANOG_19829295_ChIP-Seq_ESCs_Human1.39769835
47SOX2_19829295_ChIP-Seq_ESCs_Human1.39769835
48* TCF4_23295773_ChIP-Seq_U87_Human1.38184847
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36968184
50RNF2_27304074_Chip-Seq_NSC_Mouse1.36381541
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33035743
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.32321124
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31599788
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30414263
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30119111
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27781849
57* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27757112
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.26826474
59* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24514389
60TCF4_22108803_ChIP-Seq_LS180_Human1.23990407
61RUNX2_22187159_ChIP-Seq_PCA_Human1.23026452
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.22206743
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22206743
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18510773
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.17302277
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16649266
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.16602140
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15681347
69AR_20517297_ChIP-Seq_VCAP_Human1.15391452
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15161378
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.14275113
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13742892
73* NCOR_22424771_ChIP-Seq_293T_Human1.13315583
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12348187
75ETV1_20927104_ChIP-Seq_GIST48_Human1.11167756
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.10525769
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.10230321
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09730459
79VDR_23849224_ChIP-Seq_CD4+_Human1.08930662
80PHF8_20622853_ChIP-Seq_HELA_Human1.08269598
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.07510767
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06731248
83NFYB_21822215_ChIP-Seq_K562_Human1.05067610
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.05011734
85CDX2_22108803_ChIP-Seq_LS180_Human1.03056510
86TBL1_22424771_ChIP-Seq_293T_Human1.02284550
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02158218
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01804417
89HTT_18923047_ChIP-ChIP_STHdh_Human1.01785676
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01374692
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00909427
92RBPJ_21746931_ChIP-Seq_IB4_Human0.99461886
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99220169
94* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98911472
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97919376
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97769023
97HOXB7_26014856_ChIP-Seq_BT474_Human0.97506536
98REST_21632747_ChIP-Seq_MESCs_Mouse0.95942144
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95684053
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93929507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.45880097
2MP0006292_abnormal_olfactory_placode2.36931296
3MP0005410_abnormal_fertilization2.27427832
4MP0005551_abnormal_eye_electrophysiolog2.22201874
5MP0003136_yellow_coat_color2.20749917
6MP0003718_maternal_effect2.18639650
7MP0003195_calcinosis2.17110725
8MP0008058_abnormal_DNA_repair2.08802770
9MP0002653_abnormal_ependyma_morphology2.08439643
10MP0002876_abnormal_thyroid_physiology2.07219344
11MP0008995_early_reproductive_senescence2.04300680
12MP0001968_abnormal_touch/_nociception1.94765671
13MP0003880_abnormal_central_pattern1.90938828
14MP0001929_abnormal_gametogenesis1.80378667
15MP0006072_abnormal_retinal_apoptosis1.77274897
16MP0003698_abnormal_male_reproductive1.71518222
17MP0000569_abnormal_digit_pigmentation1.69910644
18MP0002160_abnormal_reproductive_system1.64582313
19MP0002210_abnormal_sex_determination1.64493544
20MP0005646_abnormal_pituitary_gland1.62677110
21MP0002102_abnormal_ear_morphology1.57578521
22MP0010386_abnormal_urinary_bladder1.54684209
23MP0003787_abnormal_imprinting1.53449033
24MP0005423_abnormal_somatic_nervous1.53022961
25MP0005645_abnormal_hypothalamus_physiol1.52833353
26MP0005253_abnormal_eye_physiology1.50430989
27MP0008875_abnormal_xenobiotic_pharmacok1.50416792
28MP0009046_muscle_twitch1.48185825
29MP0001984_abnormal_olfaction1.47294134
30MP0002638_abnormal_pupillary_reflex1.47291522
31MP0002735_abnormal_chemical_nociception1.42476187
32MP0008872_abnormal_physiological_respon1.41879204
33MP0003646_muscle_fatigue1.41180378
34MP0009745_abnormal_behavioral_response1.39270049
35MP0002736_abnormal_nociception_after1.38763095
36MP0003119_abnormal_digestive_system1.38485842
37MP0008789_abnormal_olfactory_epithelium1.37228019
38MP0000427_abnormal_hair_cycle1.37159961
39MP0003950_abnormal_plasma_membrane1.36046408
40MP0005377_hearing/vestibular/ear_phenot1.35163636
41MP0003878_abnormal_ear_physiology1.35163636
42MP0003890_abnormal_embryonic-extraembry1.33305368
43MP0005360_urolithiasis1.33007207
44MP0001145_abnormal_male_reproductive1.32840269
45MP0000383_abnormal_hair_follicle1.32465812
46MP0001485_abnormal_pinna_reflex1.32189852
47MP0001486_abnormal_startle_reflex1.30692897
48MP0002234_abnormal_pharynx_morphology1.30512991
49MP0000653_abnormal_sex_gland1.30192059
50MP0000631_abnormal_neuroendocrine_gland1.30107231
51MP0003693_abnormal_embryo_hatching1.29493451
52MP0004043_abnormal_pH_regulation1.29087844
53MP0002272_abnormal_nervous_system1.28963416
54MP0003937_abnormal_limbs/digits/tail_de1.26035925
55MP0002938_white_spotting1.25433038
56MP0006276_abnormal_autonomic_nervous1.25192366
57MP0005389_reproductive_system_phenotype1.24061725
58MP0009780_abnormal_chondrocyte_physiolo1.17833033
59MP0008004_abnormal_stomach_pH1.17432648
60MP0004742_abnormal_vestibular_system1.15716025
61MP0004133_heterotaxia1.14858610
62MP0003315_abnormal_perineum_morphology1.10247505
63MP0010094_abnormal_chromosome_stability1.10193290
64MP0003786_premature_aging1.09922677
65MP0002184_abnormal_innervation1.08488239
66MP0002557_abnormal_social/conspecific_i1.05114380
67MP0000647_abnormal_sebaceous_gland1.04920413
68MP0008057_abnormal_DNA_replication1.04418279
69MP0001970_abnormal_pain_threshold1.02264950
70MP0002837_dystrophic_cardiac_calcinosis1.01489901
71MP0004147_increased_porphyrin_level1.00186155
72MP0002928_abnormal_bile_duct0.98465950
73MP0005195_abnormal_posterior_eye0.97215173
74MP0005174_abnormal_tail_pigmentation0.95867810
75MP0001529_abnormal_vocalization0.94993942
76MP0006035_abnormal_mitochondrial_morpho0.93834009
77MP0004215_abnormal_myocardial_fiber0.93184196
78MP0001501_abnormal_sleep_pattern0.93057600
79MP0000026_abnormal_inner_ear0.92817515
80MP0010678_abnormal_skin_adnexa0.92647244
81MP0009697_abnormal_copulation0.92440445
82MP0002752_abnormal_somatic_nervous0.92095137
83MP0003121_genomic_imprinting0.90461007
84MP0001963_abnormal_hearing_physiology0.89702124
85MP0005394_taste/olfaction_phenotype0.89617074
86MP0005499_abnormal_olfactory_system0.89617074
87MP0005187_abnormal_penis_morphology0.89421481
88MP0002161_abnormal_fertility/fecundity0.88673788
89MP0002229_neurodegeneration0.86599764
90MP0005395_other_phenotype0.86212373
91MP0000778_abnormal_nervous_system0.85713942
92MP0003941_abnormal_skin_development0.84993721
93MP0004142_abnormal_muscle_tone0.84842789
94MP0002572_abnormal_emotion/affect_behav0.84608529
95MP0003011_delayed_dark_adaptation0.84040318
96MP0002733_abnormal_thermal_nociception0.82027194
97MP0001293_anophthalmia0.81946750
98MP0002163_abnormal_gland_morphology0.80924497
99MP0002751_abnormal_autonomic_nervous0.78412519
100MP0001764_abnormal_homeostasis0.77136535

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.01091599
2Absent/shortened dynein arms (HP:0200106)4.01091599
3Pancreatic cysts (HP:0001737)3.80747596
4Abnormality of midbrain morphology (HP:0002418)3.77348912
5Molar tooth sign on MRI (HP:0002419)3.77348912
6True hermaphroditism (HP:0010459)3.69529199
7Pancreatic fibrosis (HP:0100732)3.58592218
8Abnormal respiratory epithelium morphology (HP:0012253)3.55529101
9Abnormal respiratory motile cilium morphology (HP:0005938)3.55529101
10Abnormal ciliary motility (HP:0012262)3.54431095
11Abnormal respiratory motile cilium physiology (HP:0012261)3.43458941
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.41591004
13Nephronophthisis (HP:0000090)3.22573197
14Type II lissencephaly (HP:0007260)3.13082401
15Congenital stationary night blindness (HP:0007642)3.06390228
16Medial flaring of the eyebrow (HP:0010747)3.00065310
17Rhinitis (HP:0012384)2.99935272
18Chronic hepatic failure (HP:0100626)2.84947277
19Abnormality of the renal medulla (HP:0100957)2.81701832
20Abnormality of the renal cortex (HP:0011035)2.80830498
21Cerebellar dysplasia (HP:0007033)2.80692980
22Attenuation of retinal blood vessels (HP:0007843)2.80541715
23Abnormal rod and cone electroretinograms (HP:0008323)2.78887124
24Thyroid-stimulating hormone excess (HP:0002925)2.71835650
25Tubular atrophy (HP:0000092)2.70947328
26Intestinal atresia (HP:0011100)2.70717473
27Volvulus (HP:0002580)2.66087909
28Pendular nystagmus (HP:0012043)2.55125768
29Large for gestational age (HP:0001520)2.47472301
30Gait imbalance (HP:0002141)2.47459613
31Congenital primary aphakia (HP:0007707)2.46851804
32Cystic liver disease (HP:0006706)2.44721402
33Abnormality of macular pigmentation (HP:0008002)2.43660347
34Severe visual impairment (HP:0001141)2.42939939
35Sclerocornea (HP:0000647)2.41991429
36Male pseudohermaphroditism (HP:0000037)2.34802977
37Abnormality of the ileum (HP:0001549)2.31493374
38Abolished electroretinogram (ERG) (HP:0000550)2.29436322
393-Methylglutaconic aciduria (HP:0003535)2.22796797
40Lissencephaly (HP:0001339)2.22445508
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.20619908
42Optic nerve hypoplasia (HP:0000609)2.20429709
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20421080
44Nephrogenic diabetes insipidus (HP:0009806)2.20379226
45Progressive inability to walk (HP:0002505)2.19552243
46Gaze-evoked nystagmus (HP:0000640)2.17343954
47Chronic bronchitis (HP:0004469)2.16810131
48Bony spicule pigmentary retinopathy (HP:0007737)2.14619231
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13260542
50Abnormality of alanine metabolism (HP:0010916)2.13260542
51Hyperalaninemia (HP:0003348)2.13260542
52Inability to walk (HP:0002540)2.11775036
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.10804071
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09806562
55Acute necrotizing encephalopathy (HP:0006965)2.09134219
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08040954
57Anencephaly (HP:0002323)2.07915533
58Hypoplasia of the pons (HP:0012110)2.07639823
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.07443886
60Hypoplasia of the fovea (HP:0007750)2.07443886
61Genital tract atresia (HP:0001827)2.06479118
62Polydipsia (HP:0001959)2.06091151
63Abnormal drinking behavior (HP:0030082)2.06091151
64Occipital encephalocele (HP:0002085)2.04130044
65Vaginal atresia (HP:0000148)2.04087473
66Increased CSF lactate (HP:0002490)2.03492581
67Decreased central vision (HP:0007663)2.03338229
68Abnormality of the pons (HP:0007361)2.02702417
69Chromsome breakage (HP:0040012)2.00352892
70Gastrointestinal atresia (HP:0002589)1.98936471
71Bile duct proliferation (HP:0001408)1.96750011
72Abnormal biliary tract physiology (HP:0012439)1.96750011
73Acute encephalopathy (HP:0006846)1.95563980
74Oligodactyly (hands) (HP:0001180)1.94063198
75Meckel diverticulum (HP:0002245)1.93601087
76Renal cortical cysts (HP:0000803)1.93246425
77Aplasia/hypoplasia of the uterus (HP:0008684)1.92565184
78Furrowed tongue (HP:0000221)1.89188712
79Stomach cancer (HP:0012126)1.87863681
80Retinal dysplasia (HP:0007973)1.86363640
81Abnormality of the fovea (HP:0000493)1.85189731
82Congenital hepatic fibrosis (HP:0002612)1.83931978
83Central scotoma (HP:0000603)1.83012696
84Broad-based gait (HP:0002136)1.81477768
85Tubulointerstitial nephritis (HP:0001970)1.81372470
86Mitochondrial inheritance (HP:0001427)1.81348949
87Abnormal mitochondria in muscle tissue (HP:0008316)1.81099486
88Bronchiectasis (HP:0002110)1.81082220
89Aplasia/Hypoplasia of the tibia (HP:0005772)1.78623580
90Poor coordination (HP:0002370)1.75294374
91Polyuria (HP:0000103)1.74594411
92Preaxial hand polydactyly (HP:0001177)1.74013401
93Postaxial foot polydactyly (HP:0001830)1.73716167
94Hyperventilation (HP:0002883)1.73714265
95Progressive macrocephaly (HP:0004481)1.72684420
96Astigmatism (HP:0000483)1.70173418
97Small hand (HP:0200055)1.69043832
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.66220200
99Dandy-Walker malformation (HP:0001305)1.65625480
100Increased corneal curvature (HP:0100692)1.65390417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.16191877
2ADRBK23.62494498
3PNCK3.22366507
4ZAK2.93462680
5BMPR1B2.91003048
6PINK12.67478798
7WNK32.46484285
8TNIK2.46068397
9ACVR1B2.36998876
10MST42.16114107
11CASK2.11325214
12MAP4K22.03200392
13GRK12.02854349
14TRIM281.95895255
15WNK41.91322957
16PLK41.86455444
17INSRR1.76571514
18MAP3K41.69985343
19NUAK11.63220513
20PBK1.59920746
21STK391.53383127
22TAOK31.51147943
23STK38L1.47976982
24EIF2AK31.43763252
25WEE11.40498338
26TLK11.36994131
27MAP2K71.33994110
28MUSK1.33344353
29MKNK21.31457380
30OXSR11.25676176
31BCR1.25250266
32TGFBR11.22768831
33BRSK21.22235582
34CAMK1G1.20972649
35MAPK131.12514349
36ADRBK11.11201933
37PLK21.06382612
38VRK11.06238105
39PRKCE1.04765541
40PRKCG1.04673406
41TSSK61.00759267
42PLK10.96791679
43MAPK150.93056107
44PASK0.90789561
45BUB10.89896268
46DYRK30.89620105
47PLK30.87764703
48TTK0.86335150
49SRPK10.85064699
50MAP3K120.81684223
51MARK10.80125512
52NLK0.79541104
53DYRK20.79517354
54NEK20.79361165
55NEK10.75036639
56MKNK10.73927171
57PTK2B0.73387838
58PRKCI0.72520063
59MET0.70224640
60CSNK1G10.69298581
61CAMK1D0.68982235
62BRD40.68640729
63VRK20.66459850
64AKT30.65996030
65STK30.65818075
66CSNK1G20.62032357
67STK380.60571121
68PAK30.59551889
69ATR0.58246823
70CHEK20.55127209
71NME10.53304143
72PHKG20.52602487
73PHKG10.52602487
74LIMK10.52397462
75ATM0.50167659
76CSNK1G30.50116366
77CAMK2A0.50043477
78ERBB30.48526339
79CDC70.43301270
80STK160.42135502
81CCNB10.41505811
82CSNK1E0.41200680
83TXK0.40936950
84NTRK30.40594997
85CSNK1A1L0.40209706
86AURKA0.38610064
87BRSK10.37656204
88DAPK20.37496584
89PRKACA0.36184031
90MAP2K10.35984351
91DYRK1A0.35980686
92EPHA40.34075389
93MAP2K20.33049642
94EIF2AK10.32032820
95TAF10.30528248
96FLT30.28351540
97WNK10.27418798
98PKN10.27223333
99CDK190.27080066
100RPS6KA50.26962637

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66183930
2Phototransduction_Homo sapiens_hsa047442.43401005
3Homologous recombination_Homo sapiens_hsa034402.41301267
4Fanconi anemia pathway_Homo sapiens_hsa034602.25404459
5Protein export_Homo sapiens_hsa030602.24156077
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22548703
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22051637
8Butanoate metabolism_Homo sapiens_hsa006502.16687775
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.13896579
10Oxidative phosphorylation_Homo sapiens_hsa001902.12340135
11Basal transcription factors_Homo sapiens_hsa030222.00473522
12Parkinsons disease_Homo sapiens_hsa050121.89089808
13RNA polymerase_Homo sapiens_hsa030201.86630597
14Proteasome_Homo sapiens_hsa030501.79520140
15Selenocompound metabolism_Homo sapiens_hsa004501.77689892
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75502413
17Linoleic acid metabolism_Homo sapiens_hsa005911.73309888
18Huntingtons disease_Homo sapiens_hsa050161.70044113
19Propanoate metabolism_Homo sapiens_hsa006401.69959856
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64005830
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59554617
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55637982
23Olfactory transduction_Homo sapiens_hsa047401.55020044
24RNA degradation_Homo sapiens_hsa030181.54927402
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50752799
26Nicotine addiction_Homo sapiens_hsa050331.48637686
27Mismatch repair_Homo sapiens_hsa034301.46164504
28One carbon pool by folate_Homo sapiens_hsa006701.45467249
29Nitrogen metabolism_Homo sapiens_hsa009101.43678038
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43564590
31Taste transduction_Homo sapiens_hsa047421.40950481
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39618237
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29834877
34Non-homologous end-joining_Homo sapiens_hsa034501.29510298
35Nucleotide excision repair_Homo sapiens_hsa034201.26583981
36RNA transport_Homo sapiens_hsa030131.24679883
37Ether lipid metabolism_Homo sapiens_hsa005651.23348544
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.23165820
39Retinol metabolism_Homo sapiens_hsa008301.19385415
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14684773
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.13494331
42Chemical carcinogenesis_Homo sapiens_hsa052041.13263630
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13047213
44Peroxisome_Homo sapiens_hsa041461.12735451
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11684236
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11217369
47Alzheimers disease_Homo sapiens_hsa050101.09571950
48Tryptophan metabolism_Homo sapiens_hsa003801.09434789
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04628566
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03775486
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.03543625
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02149799
53Purine metabolism_Homo sapiens_hsa002301.00745800
54Steroid biosynthesis_Homo sapiens_hsa001001.00619634
55Base excision repair_Homo sapiens_hsa034100.99625286
56Pyrimidine metabolism_Homo sapiens_hsa002400.98230993
57Cardiac muscle contraction_Homo sapiens_hsa042600.95666163
58Morphine addiction_Homo sapiens_hsa050320.91947227
59beta-Alanine metabolism_Homo sapiens_hsa004100.91893767
60Metabolic pathways_Homo sapiens_hsa011000.86818273
61Serotonergic synapse_Homo sapiens_hsa047260.82574951
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80148205
63DNA replication_Homo sapiens_hsa030300.79970580
64Ribosome_Homo sapiens_hsa030100.79439052
65Fatty acid biosynthesis_Homo sapiens_hsa000610.79215740
66Pyruvate metabolism_Homo sapiens_hsa006200.78518892
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76454144
68Regulation of autophagy_Homo sapiens_hsa041400.75732285
69Caffeine metabolism_Homo sapiens_hsa002320.75409151
70Insulin secretion_Homo sapiens_hsa049110.74814405
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67867934
72Hedgehog signaling pathway_Homo sapiens_hsa043400.66597028
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65411387
74Arachidonic acid metabolism_Homo sapiens_hsa005900.64927925
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64342619
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63740652
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63077613
78ABC transporters_Homo sapiens_hsa020100.62844496
79GABAergic synapse_Homo sapiens_hsa047270.61225550
80Glycerolipid metabolism_Homo sapiens_hsa005610.60936433
81Sulfur relay system_Homo sapiens_hsa041220.59435192
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59309394
83Ovarian steroidogenesis_Homo sapiens_hsa049130.58593631
84Cell cycle_Homo sapiens_hsa041100.58015162
85Dorso-ventral axis formation_Homo sapiens_hsa043200.57995011
86Sphingolipid metabolism_Homo sapiens_hsa006000.55506544
87Fatty acid elongation_Homo sapiens_hsa000620.54637419
88Sulfur metabolism_Homo sapiens_hsa009200.53250433
89Oocyte meiosis_Homo sapiens_hsa041140.52704747
90Circadian entrainment_Homo sapiens_hsa047130.52552753
91p53 signaling pathway_Homo sapiens_hsa041150.52430142
92Spliceosome_Homo sapiens_hsa030400.52356933
93Glutathione metabolism_Homo sapiens_hsa004800.51721001
94Glutamatergic synapse_Homo sapiens_hsa047240.50722674
95Fatty acid degradation_Homo sapiens_hsa000710.50244249
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47822915
97Fatty acid metabolism_Homo sapiens_hsa012120.46820168
98Circadian rhythm_Homo sapiens_hsa047100.45483438
99Basal cell carcinoma_Homo sapiens_hsa052170.45253913
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43115269

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