ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	6.42613764
2	presynaptic membrane organization (GO:0097090)	5.72329452
3	postsynaptic membrane organization (GO:0001941)	5.46626403
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.89772392
5	neuron cell-cell adhesion (GO:0007158)	4.79312164
6	mechanosensory behavior (GO:0007638)	4.38933631
7	auditory behavior (GO:0031223)	4.33083249
8	C4-dicarboxylate transport (GO:0015740)	4.29247292
9	nucleobase catabolic process (GO:0046113)	4.04249414
10	limb bud formation (GO:0060174)	3.89184548
11	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.87006259
12	neurotransmitter-gated ion channel clustering (GO:0072578)	3.82384374
13	startle response (GO:0001964)	3.80743884
14	gamma-aminobutyric acid transport (GO:0015812)	3.79593610
15	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.70698752
16	nonmotile primary cilium assembly (GO:0035058)	3.65715028
17	glutamate receptor signaling pathway (GO:0007215)	3.61476810
18	vocalization behavior (GO:0071625)	3.61167471
19	response to pheromone (GO:0019236)	3.45819208
20	cerebral cortex radially oriented cell migration (GO:0021799)	3.45655525
21	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.44964388
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.37533882
23	neuronal action potential propagation (GO:0019227)	3.36702010
24	neuron recognition (GO:0008038)	3.30747942
25	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.21014576
26	central nervous system projection neuron axonogenesis (GO:0021952)	3.20882865
27	regulation of translation, ncRNA-mediated (GO:0045974)	3.19873856
28	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.19873856
29	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.19873856
30	righting reflex (GO:0060013)	3.19286598
31	synaptic transmission, glutamatergic (GO:0035249)	3.16354967
32	DNA double-strand break processing (GO:0000729)	3.13172459
33	behavioral response to nicotine (GO:0035095)	3.05552497
34	somite development (GO:0061053)	3.01583641
35	neurotransmitter uptake (GO:0001504)	2.98273360
36	synapse assembly (GO:0007416)	2.97608389
37	transmission of nerve impulse (GO:0019226)	2.97123105
38	reflex (GO:0060004)	2.92936239
39	response to auditory stimulus (GO:0010996)	2.92136935
40	protein localization to synapse (GO:0035418)	2.91897047
41	axonal fasciculation (GO:0007413)	2.91550336
42	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.91521921
43	central nervous system neuron axonogenesis (GO:0021955)	2.89098789
44	behavioral response to ethanol (GO:0048149)	2.81540743
45	positive regulation of synapse assembly (GO:0051965)	2.79919276
46	neural tube formation (GO:0001841)	2.79517410
47	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.77769945
48	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.76313768
49	retinal ganglion cell axon guidance (GO:0031290)	2.75447194
50	L-fucose catabolic process (GO:0042355)	2.74964463
51	fucose catabolic process (GO:0019317)	2.74964463
52	L-fucose metabolic process (GO:0042354)	2.74964463
53	regulation of collateral sprouting (GO:0048670)	2.73609407
54	glycosphingolipid biosynthetic process (GO:0006688)	2.70248819
55	retinal cone cell development (GO:0046549)	2.69580807
56	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.69351019
57	spinal cord development (GO:0021510)	2.68729737
58	sympathetic nervous system development (GO:0048485)	2.68463266
59	neuron-neuron synaptic transmission (GO:0007270)	2.68291401
60	regulation of timing of cell differentiation (GO:0048505)	2.66556368
61	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.66146878
62	inner ear receptor stereocilium organization (GO:0060122)	2.65583666
63	L-amino acid import (GO:0043092)	2.63122492
64	serotonin metabolic process (GO:0042428)	2.61545728
65	positive regulation of meiosis (GO:0045836)	2.61397254
66	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.61032668
67	photoreceptor cell maintenance (GO:0045494)	2.60543772
68	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.59815157
69	auditory receptor cell stereocilium organization (GO:0060088)	2.59276679
70	protein polyglutamylation (GO:0018095)	2.59209434
71	dendritic spine morphogenesis (GO:0060997)	2.58548538
72	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.57889595
73	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.54376840
74	regulation of respiratory system process (GO:0044065)	2.53966857
75	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.53088054
76	cochlea development (GO:0090102)	2.51889416
77	negative regulation of astrocyte differentiation (GO:0048712)	2.51712571
78	atrial cardiac muscle cell action potential (GO:0086014)	2.51189695
79	regulation of neurotransmitter uptake (GO:0051580)	2.50944042
80	protein K11-linked deubiquitination (GO:0035871)	2.50472034
81	membrane depolarization during action potential (GO:0086010)	2.49870916
82	neuronal action potential (GO:0019228)	2.49640000
83	cornea development in camera-type eye (GO:0061303)	2.48981747
84	cAMP catabolic process (GO:0006198)	2.48099354
85	regulation of action potential (GO:0098900)	2.47658097
86	regulation of meiosis I (GO:0060631)	2.47062490
87	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.47008727
88	negative regulation of neurotransmitter transport (GO:0051589)	2.44792087
89	regulation of synapse structural plasticity (GO:0051823)	2.44629301
90	olfactory bulb development (GO:0021772)	2.44216419
91	cyclic nucleotide catabolic process (GO:0009214)	2.43954046
92	adult walking behavior (GO:0007628)	2.42600017
93	cellular response to cholesterol (GO:0071397)	2.41968557
94	replication fork processing (GO:0031297)	2.40925676
95	glial cell proliferation (GO:0014009)	2.40465317
96	positive regulation of meiotic cell cycle (GO:0051446)	2.40324258
97	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.39281471
98	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.38441755
99	neuromuscular synaptic transmission (GO:0007274)	2.38286253
100	regulation of synapse assembly (GO:0051963)	2.38014550

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.95555716
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.94429402
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.19209963
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.09147740
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94380408
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.66212831
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.62611603
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.60303615
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57805354
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55638202
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49429984
12	VDR_22108803_ChIP-Seq_LS180_Human	2.38156405
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25871994
14	P300_19829295_ChIP-Seq_ESCs_Human	2.16885318
15	FUS_26573619_Chip-Seq_HEK293_Human	2.14214222
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13818525
17	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.10342853
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.09690356
19	EWS_26573619_Chip-Seq_HEK293_Human	2.06139334
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06068314
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98286610
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.97641223
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.95042694
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88535253
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.85293087
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83948929
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.83257435
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.71719958
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.71063221
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.70557068
31	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.68184361
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.67929356
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.67551195
34	AR_25329375_ChIP-Seq_VCAP_Human	1.66405433
35	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.65051420
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63837566
37	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.62808182
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.60322786
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.57612588
40	STAT3_23295773_ChIP-Seq_U87_Human	1.57503301
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57480797
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55475732
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54202107
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54202107
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52437233
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.51269477
47	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.48873676
48	TCF4_23295773_ChIP-Seq_U87_Human	1.47430234
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41702667
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40141350
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39968629
52	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.38231786
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33504732
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31516783
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31232752
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30372101
57	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.29249067
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.28464880
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28464880
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27399651
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.26631645
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26279020
63	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26147950
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23712334
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23463187
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23079115
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22213338
68	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21397534
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19455959
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.19382064
71	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.18066584
72	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17909228
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17903657
74	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17094351
75	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16741757
76	SOX9_26525672_Chip-Seq_HEART_Mouse	1.16230945
77	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.16195253
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.16125529
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14280110
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13924888
81	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.13606677
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13198335
83	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10662874
84	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.10636377
85	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.09910619
86	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09516261
87	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.08870561
88	KDM2B_26808549_Chip-Seq_REH_Human	1.08510366
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.08416216
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07669833
91	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.06289962
92	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.06289962
93	JUN_21703547_ChIP-Seq_K562_Human	1.06139982
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06123783
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04520101
96	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03474031
97	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03445633
98	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03445633
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02438166
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.01792020

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	4.21125175
2	MP0001968_abnormal_touch/_nociception	3.52761614
3	MP0003880_abnormal_central_pattern	3.44227607
4	MP0000569_abnormal_digit_pigmentation	2.68109206
5	MP0001486_abnormal_startle_reflex	2.42470685
6	MP0002735_abnormal_chemical_nociception	2.38126905
7	MP0004859_abnormal_synaptic_plasticity	2.34447010
8	MP0005423_abnormal_somatic_nervous	2.28918498
9	MP0003635_abnormal_synaptic_transmissio	2.25251636
10	MP0009745_abnormal_behavioral_response	2.23180662
11	MP0004885_abnormal_endolymph	2.20010580
12	MP0005551_abnormal_eye_electrophysiolog	2.13958706
13	MP0004270_analgesia	2.12539085
14	MP0002272_abnormal_nervous_system	2.08780201
15	MP0000778_abnormal_nervous_system	2.06176557
16	MP0002064_seizures	1.95183871
17	MP0009046_muscle_twitch	1.91314117
18	MP0002734_abnormal_mechanical_nocicepti	1.89556397
19	MP0002063_abnormal_learning/memory/cond	1.88210024
20	MP0003787_abnormal_imprinting	1.85654960
21	MP0001984_abnormal_olfaction	1.83840366
22	MP0005646_abnormal_pituitary_gland	1.81820390
23	MP0003136_yellow_coat_color	1.75987231
24	MP0008877_abnormal_DNA_methylation	1.75833779
25	MP0002102_abnormal_ear_morphology	1.73123039
26	MP0002572_abnormal_emotion/affect_behav	1.68837744
27	MP0005253_abnormal_eye_physiology	1.63839018
28	MP0001970_abnormal_pain_threshold	1.63667725
29	MP0005171_absent_coat_pigmentation	1.62183305
30	MP0002067_abnormal_sensory_capabilities	1.60127871
31	MP0002733_abnormal_thermal_nociception	1.59832699
32	MP0006292_abnormal_olfactory_placode	1.53002280
33	MP0006072_abnormal_retinal_apoptosis	1.51125666
34	MP0002557_abnormal_social/conspecific_i	1.50082797
35	MP0002938_white_spotting	1.45034474
36	MP0000631_abnormal_neuroendocrine_gland	1.44994790
37	MP0000516_abnormal_urinary_system	1.42555501
38	MP0005367_renal/urinary_system_phenotyp	1.42555501
39	MP0001501_abnormal_sleep_pattern	1.40679321
40	MP0002751_abnormal_autonomic_nervous	1.38616280
41	MP0004742_abnormal_vestibular_system	1.36615739
42	MP0001529_abnormal_vocalization	1.36261508
43	MP0004142_abnormal_muscle_tone	1.34931858
44	MP0005174_abnormal_tail_pigmentation	1.34067367
45	MP0001485_abnormal_pinna_reflex	1.32707162
46	MP0002837_dystrophic_cardiac_calcinosis	1.32319940
47	MP0006276_abnormal_autonomic_nervous	1.31223037
48	MP0001986_abnormal_taste_sensitivity	1.27812433
49	MP0002638_abnormal_pupillary_reflex	1.27581613
50	MP0000955_abnormal_spinal_cord	1.27011042
51	MP0005386_behavior/neurological_phenoty	1.22113890
52	MP0004924_abnormal_behavior	1.22113890
53	MP0002184_abnormal_innervation	1.21421529
54	MP0003121_genomic_imprinting	1.18336944
55	MP0002882_abnormal_neuron_morphology	1.17856929
56	MP0004043_abnormal_pH_regulation	1.17791916
57	MP0005187_abnormal_penis_morphology	1.16749293
58	MP0002752_abnormal_somatic_nervous	1.14759623
59	MP0000026_abnormal_inner_ear	1.12052948
60	MP0008872_abnormal_physiological_respon	1.11473569
61	MP0008789_abnormal_olfactory_epithelium	1.08384640
62	MP0002653_abnormal_ependyma_morphology	1.07835141
63	MP0003122_maternal_imprinting	1.07635630
64	MP0000049_abnormal_middle_ear	1.06610832
65	MP0001177_atelectasis	1.05109600
66	MP0001963_abnormal_hearing_physiology	1.05065759
67	MP0005195_abnormal_posterior_eye	1.04031003
68	MP0003011_delayed_dark_adaptation	1.02778144
69	MP0000427_abnormal_hair_cycle	1.00962101
70	MP0002822_catalepsy	1.00226787
71	MP0000372_irregular_coat_pigmentation	0.98972098
72	MP0002234_abnormal_pharynx_morphology	0.98352227
73	MP0002233_abnormal_nose_morphology	0.98056571
74	MP0004133_heterotaxia	0.98037507
75	MP0003633_abnormal_nervous_system	0.97602957
76	MP0003755_abnormal_palate_morphology	0.97132072
77	MP0000566_synostosis	0.96362285
78	MP0002152_abnormal_brain_morphology	0.95907122
79	MP0002095_abnormal_skin_pigmentation	0.95897752
80	MP0003195_calcinosis	0.95095587
81	MP0003119_abnormal_digestive_system	0.93756018
82	MP0005394_taste/olfaction_phenotype	0.93326982
83	MP0005499_abnormal_olfactory_system	0.93326982
84	MP0004215_abnormal_myocardial_fiber	0.93323415
85	MP0003937_abnormal_limbs/digits/tail_de	0.92057734
86	MP0000647_abnormal_sebaceous_gland	0.90284845
87	MP0001440_abnormal_grooming_behavior	0.89711585
88	MP0002066_abnormal_motor_capabilities/c	0.89680652
89	MP0005248_abnormal_Harderian_gland	0.88689191
90	MP0002229_neurodegeneration	0.88169540
91	MP0001502_abnormal_circadian_rhythm	0.87861376
92	MP0008569_lethality_at_weaning	0.83821296
93	MP0005645_abnormal_hypothalamus_physiol	0.83346821
94	MP0004145_abnormal_muscle_electrophysio	0.80371836
95	MP0004147_increased_porphyrin_level	0.79963898
96	MP0005391_vision/eye_phenotype	0.78421679
97	MP0003861_abnormal_nervous_system	0.78348948
98	MP0003137_abnormal_impulse_conducting	0.77294077
99	MP0000534_abnormal_ureter_morphology	0.76108855
100	MP0003890_abnormal_embryonic-extraembry	0.75534060

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	5.71488637
2	Focal motor seizures (HP:0011153)	4.13513771
3	Hemiparesis (HP:0001269)	3.95146281
4	True hermaphroditism (HP:0010459)	3.74936748
5	Pancreatic cysts (HP:0001737)	3.49956416
6	Pancreatic fibrosis (HP:0100732)	3.39499825
7	Molar tooth sign on MRI (HP:0002419)	3.26525742
8	Abnormality of midbrain morphology (HP:0002418)	3.26525742
9	Broad-based gait (HP:0002136)	3.23550343
10	Absent speech (HP:0001344)	2.99519361
11	Focal seizures (HP:0007359)	2.95199257
12	Nephronophthisis (HP:0000090)	2.93682047
13	Febrile seizures (HP:0002373)	2.87928127
14	Medial flaring of the eyebrow (HP:0010747)	2.81941016
15	Congenital stationary night blindness (HP:0007642)	2.80527838
16	Colon cancer (HP:0003003)	2.79284007
17	Drooling (HP:0002307)	2.75211295
18	Abnormality of the labia minora (HP:0012880)	2.71933600
19	Progressive cerebellar ataxia (HP:0002073)	2.70026779
20	Hemiplegia (HP:0002301)	2.69186644
21	Type II lissencephaly (HP:0007260)	2.66969838
22	Megalencephaly (HP:0001355)	2.66470197
23	Gait imbalance (HP:0002141)	2.63151929
24	Congenital sensorineural hearing impairment (HP:0008527)	2.56343428
25	Stomach cancer (HP:0012126)	2.54360714
26	Protruding tongue (HP:0010808)	2.52804541
27	Intestinal atresia (HP:0011100)	2.51238906
28	Genital tract atresia (HP:0001827)	2.48741292
29	Abnormality of the renal medulla (HP:0100957)	2.47840526
30	Excessive salivation (HP:0003781)	2.47527517
31	Abolished electroretinogram (ERG) (HP:0000550)	2.45946498
32	Hepatoblastoma (HP:0002884)	2.43153147
33	Increased corneal curvature (HP:0100692)	2.41645222
34	Keratoconus (HP:0000563)	2.41645222
35	Retinal dysplasia (HP:0007973)	2.41122395
36	Lissencephaly (HP:0001339)	2.40437411
37	Astrocytoma (HP:0009592)	2.40102622
38	Abnormality of the astrocytes (HP:0100707)	2.40102622
39	Vaginal atresia (HP:0000148)	2.36424151
40	Congenital primary aphakia (HP:0007707)	2.35914937
41	Gaze-evoked nystagmus (HP:0000640)	2.33186755
42	Chronic hepatic failure (HP:0100626)	2.32925097
43	Pendular nystagmus (HP:0012043)	2.32635534
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.31427631
45	Epileptic encephalopathy (HP:0200134)	2.30431149
46	Glioma (HP:0009733)	2.26472072
47	Abnormality of the renal cortex (HP:0011035)	2.25360387
48	Action tremor (HP:0002345)	2.21162364
49	Nephrogenic diabetes insipidus (HP:0009806)	2.20580451
50	Limb dystonia (HP:0002451)	2.20571643
51	Oligodactyly (hands) (HP:0001180)	2.19997262
52	Optic nerve hypoplasia (HP:0000609)	2.18803960
53	Cystic liver disease (HP:0006706)	2.16007008
54	Sclerocornea (HP:0000647)	2.14903059
55	Neoplasm of the adrenal cortex (HP:0100641)	2.11975157
56	Postaxial hand polydactyly (HP:0001162)	2.11637073
57	Inability to walk (HP:0002540)	2.09758918
58	Dialeptic seizures (HP:0011146)	2.07319304
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05975333
60	Chorioretinal atrophy (HP:0000533)	2.03478619
61	Pachygyria (HP:0001302)	2.03138992
62	Volvulus (HP:0002580)	2.00334506
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97892623
64	Atonic seizures (HP:0010819)	1.97347038
65	Epidermoid cyst (HP:0200040)	1.97229367
66	Generalized tonic-clonic seizures (HP:0002069)	1.96454377
67	Congenital hepatic fibrosis (HP:0002612)	1.95106188
68	Renal hypoplasia (HP:0000089)	1.92262320
69	Narrow forehead (HP:0000341)	1.89967510
70	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.88207213
71	Renal cortical cysts (HP:0000803)	1.87774837
72	Attenuation of retinal blood vessels (HP:0007843)	1.86207025
73	Postaxial foot polydactyly (HP:0001830)	1.85342217
74	Specific learning disability (HP:0001328)	1.84480089
75	Widely spaced teeth (HP:0000687)	1.84471561
76	Gastrointestinal atresia (HP:0002589)	1.84026611
77	Hypsarrhythmia (HP:0002521)	1.83619763
78	Anencephaly (HP:0002323)	1.83334992
79	Epileptiform EEG discharges (HP:0011182)	1.81296898
80	Tented upper lip vermilion (HP:0010804)	1.81236194
81	Male pseudohermaphroditism (HP:0000037)	1.79605110
82	EEG with generalized epileptiform discharges (HP:0011198)	1.78719360
83	Anophthalmia (HP:0000528)	1.78298200
84	Genetic anticipation (HP:0003743)	1.77121459
85	Bifid tongue (HP:0010297)	1.77025231
86	Preaxial hand polydactyly (HP:0001177)	1.76339358
87	Furrowed tongue (HP:0000221)	1.75792062
88	Dyskinesia (HP:0100660)	1.75758065
89	Cupped ear (HP:0000378)	1.75401267
90	Fair hair (HP:0002286)	1.75181747
91	Poor coordination (HP:0002370)	1.74861550
92	Tubular atrophy (HP:0000092)	1.74359400
93	Short tibia (HP:0005736)	1.74121912
94	Polydipsia (HP:0001959)	1.73728610
95	Abnormal drinking behavior (HP:0030082)	1.73728610
96	Progressive macrocephaly (HP:0004481)	1.73578921
97	Astigmatism (HP:0000483)	1.72773630
98	Septo-optic dysplasia (HP:0100842)	1.70800812
99	Decreased central vision (HP:0007663)	1.67450976
100	Bony spicule pigmentary retinopathy (HP:0007737)	1.67383636

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.96672455
2	FRK	4.12484401
3	MARK1	3.86568729
4	WNK3	3.17764224
5	MAPK13	3.02460600
6	MAP4K2	2.63071429
7	TNIK	2.44084583
8	BMPR1B	2.27239335
9	PNCK	2.23573683
10	NTRK3	2.20376558
11	MAP3K4	1.98437224
12	NUAK1	1.89229910
13	EPHA4	1.89150616
14	MKNK2	1.79721333
15	TRIM28	1.73556703
16	ADRBK2	1.70124352
17	ACVR1B	1.63179718
18	DYRK2	1.58456647
19	PINK1	1.56394836
20	GRK1	1.52007797
21	NTRK2	1.46403723
22	PAK3	1.35673760
23	MAP2K7	1.34577031
24	CSNK1G2	1.29757462
25	BCR	1.29746346
26	PLK2	1.29696213
27	STK39	1.28006172
28	CSNK1G1	1.24917168
29	INSRR	1.23980479
30	PKN1	1.22063689
31	ZAK	1.14133376
32	CCNB1	1.13327762
33	CSNK1G3	1.10588067
34	PRKCG	1.08040835
35	ERBB3	1.05619740
36	OXSR1	1.05262880
37	FGFR2	1.03082258
38	CSNK1A1L	1.02120756
39	WEE1	1.01670308
40	PRKD3	1.01574722
41	MINK1	0.99679513
42	PHKG1	0.99286398
43	PHKG2	0.99286398
44	PRKCE	0.92234682
45	SGK2	0.91731003
46	MKNK1	0.91141193
47	STK38L	0.89183117
48	DAPK2	0.84492038
49	CAMK2A	0.80518322
50	WNK4	0.75978171
51	SGK223	0.75698703
52	SGK494	0.75698703
53	SIK2	0.73907730
54	CAMK2B	0.73312389
55	PRKCZ	0.71242543
56	ADRBK1	0.68607730
57	ROCK1	0.67361519
58	UHMK1	0.66857623
59	PLK3	0.66763001
60	CAMK2D	0.63970630
61	DYRK1A	0.63001052
62	VRK1	0.62833692
63	AKT3	0.62152527
64	PLK4	0.60985751
65	TGFBR1	0.60795967
66	CDK5	0.57922624
67	EPHA3	0.57221391
68	CDK3	0.56851455
69	EPHB2	0.53004987
70	PTK2B	0.51234687
71	PRKACA	0.49837644
72	CSNK1A1	0.48296008
73	CSNK1D	0.47826963
74	FER	0.47038739
75	CAMKK2	0.46784495
76	EIF2AK3	0.46157282
77	CAMK2G	0.45392744
78	STK11	0.45110968
79	MAP2K4	0.43716046
80	PAK6	0.42941067
81	YES1	0.42918807
82	SGK1	0.42817677
83	MAPKAPK5	0.42290882
84	CAMK4	0.40456533
85	TAOK3	0.40276647
86	PRKG1	0.38887903
87	CAMK1	0.38709616
88	KSR1	0.38489682
89	TSSK6	0.37855264
90	BRSK2	0.36960076
91	TLK1	0.36705694
92	ERBB2	0.36073614
93	PIK3CA	0.34081553
94	FGFR1	0.32911030
95	TIE1	0.31417092
96	ATM	0.29785164
97	DMPK	0.29023887
98	GSK3A	0.28883086
99	GRK5	0.28454318
100	PRKDC	0.28178248

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.86951896
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.16383556
3	Glutamatergic synapse_Homo sapiens_hsa04724	2.33100384
4	Butanoate metabolism_Homo sapiens_hsa00650	2.31002008
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.25418530
6	Phototransduction_Homo sapiens_hsa04744	2.23650521
7	Circadian entrainment_Homo sapiens_hsa04713	2.12926430
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.03698303
9	Morphine addiction_Homo sapiens_hsa05032	2.02406998
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97514514
11	GABAergic synapse_Homo sapiens_hsa04727	1.93009166
12	Amphetamine addiction_Homo sapiens_hsa05031	1.76607515
13	Propanoate metabolism_Homo sapiens_hsa00640	1.74978980
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.72056397
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.69451299
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.68739716
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64530262
18	Taste transduction_Homo sapiens_hsa04742	1.60278244
19	Insulin secretion_Homo sapiens_hsa04911	1.59548504
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55851883
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55627058
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55130036
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.53832093
24	Cocaine addiction_Homo sapiens_hsa05030	1.52818250
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51236422
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48343415
27	Protein export_Homo sapiens_hsa03060	1.43494581
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.40911103
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40779678
30	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.33447612
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31915480
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.30697287
33	Long-term depression_Homo sapiens_hsa04730	1.27735574
34	Olfactory transduction_Homo sapiens_hsa04740	1.27276383
35	Basal transcription factors_Homo sapiens_hsa03022	1.24786178
36	Serotonergic synapse_Homo sapiens_hsa04726	1.21519009
37	Salivary secretion_Homo sapiens_hsa04970	1.21481656
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.19451370
39	Caffeine metabolism_Homo sapiens_hsa00232	1.08571305
40	Homologous recombination_Homo sapiens_hsa03440	1.07993638
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05733907
42	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.01287007
43	Gastric acid secretion_Homo sapiens_hsa04971	1.00148807
44	Axon guidance_Homo sapiens_hsa04360	0.99992062
45	Cholinergic synapse_Homo sapiens_hsa04725	0.98257142
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.97562136
47	Oxidative phosphorylation_Homo sapiens_hsa00190	0.97407338
48	Renin secretion_Homo sapiens_hsa04924	0.96665793
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96407535
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93964020
51	Calcium signaling pathway_Homo sapiens_hsa04020	0.91353604
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86440714
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83102581
54	Parkinsons disease_Homo sapiens_hsa05012	0.80908463
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.80424431
56	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.79532238
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.75693787
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74496346
59	Histidine metabolism_Homo sapiens_hsa00340	0.73078450
60	Fatty acid elongation_Homo sapiens_hsa00062	0.73058511
61	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72738915
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72420684
63	RNA degradation_Homo sapiens_hsa03018	0.72270881
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.71597609
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.70700277
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.70571490
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68746768
68	Peroxisome_Homo sapiens_hsa04146	0.66922162
69	Circadian rhythm_Homo sapiens_hsa04710	0.66879618
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66279015
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64322403
72	Regulation of autophagy_Homo sapiens_hsa04140	0.63511145
73	Retinol metabolism_Homo sapiens_hsa00830	0.63424906
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60721769
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59510326
76	Hippo signaling pathway_Homo sapiens_hsa04390	0.59053862
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58905531
78	Alzheimers disease_Homo sapiens_hsa05010	0.58293612
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58191001
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56294761
81	Oocyte meiosis_Homo sapiens_hsa04114	0.54767764
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.53862978
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.52360258
84	Fatty acid degradation_Homo sapiens_hsa00071	0.52056461
85	ABC transporters_Homo sapiens_hsa02010	0.51903157
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51572934
87	Gap junction_Homo sapiens_hsa04540	0.51331597
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50740053
89	Huntingtons disease_Homo sapiens_hsa05016	0.50181294
90	Long-term potentiation_Homo sapiens_hsa04720	0.50095393
91	RNA polymerase_Homo sapiens_hsa03020	0.49829046
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49109783
93	Pancreatic secretion_Homo sapiens_hsa04972	0.47816972
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.47520819
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.46392057
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.46022939
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45969663
98	Mineral absorption_Homo sapiens_hsa04978	0.45251130
99	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44729284
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43773437

C3ORF70

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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