C3ORF80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)7.98680030
2negative regulation of erythrocyte differentiation (GO:0045647)5.56823841
3interkinetic nuclear migration (GO:0022027)4.97165711
4aggressive behavior (GO:0002118)4.85109638
5positive regulation of vasculogenesis (GO:2001214)4.70002651
6relaxation of smooth muscle (GO:0044557)4.66616790
7positive regulation of B cell differentiation (GO:0045579)4.62482363
8synaptic vesicle maturation (GO:0016188)4.61479954
9mitochondrion transport along microtubule (GO:0047497)4.48412106
10establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.48412106
11regulation of synaptic vesicle exocytosis (GO:2000300)4.36973389
12endothelium development (GO:0003158)4.27027036
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.26239785
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21689142
15G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.19377835
16regulation of female receptivity (GO:0045924)4.11427430
17negative regulation of neurotransmitter secretion (GO:0046929)4.03765119
18establishment of mitochondrion localization (GO:0051654)3.92447607
19glutamate secretion (GO:0014047)3.90506331
20forebrain morphogenesis (GO:0048853)3.73286007
21negative regulation of neurotransmitter transport (GO:0051589)3.72667137
22regulation of synaptic vesicle transport (GO:1902803)3.68517131
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.64471595
24mucosal-associated lymphoid tissue development (GO:0048537)3.59761018
25Peyers patch development (GO:0048541)3.59761018
26thrombin receptor signaling pathway (GO:0070493)3.57784770
27negative regulation of granulocyte differentiation (GO:0030853)3.54043536
28thyroid gland development (GO:0030878)3.49977482
29negative regulation of dendrite morphogenesis (GO:0050774)3.48511704
30rRNA modification (GO:0000154)3.46126583
31female mating behavior (GO:0060180)3.44622844
32phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.41349598
33negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.37313735
34rRNA methylation (GO:0031167)3.36988553
35negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.34550792
36poly(A)+ mRNA export from nucleus (GO:0016973)3.32480654
37regulation of erythrocyte differentiation (GO:0045646)3.30919798
38hematopoietic stem cell proliferation (GO:0071425)3.30813463
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22773046
40ribosomal small subunit assembly (GO:0000028)3.22572572
41synaptic vesicle exocytosis (GO:0016079)3.21418056
42opioid receptor signaling pathway (GO:0038003)3.20331622
43negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.17395323
44monoamine transport (GO:0015844)3.13473841
45positive regulation of Rap GTPase activity (GO:0032854)3.13308915
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.12888859
47regulation of catecholamine metabolic process (GO:0042069)3.11557360
48regulation of dopamine metabolic process (GO:0042053)3.11557360
49regulation of Golgi to plasma membrane protein transport (GO:0042996)3.11317615
50amino-acid betaine transport (GO:0015838)3.10902026
51carnitine transport (GO:0015879)3.10902026
52behavioral response to pain (GO:0048266)3.09477787
53carnitine transmembrane transport (GO:1902603)3.08288419
54relaxation of muscle (GO:0090075)3.08037608
55ribosomal large subunit biogenesis (GO:0042273)3.07169251
56megakaryocyte development (GO:0035855)3.03407404
57seminiferous tubule development (GO:0072520)2.98936665
58serotonin receptor signaling pathway (GO:0007210)2.98672733
59nerve growth factor signaling pathway (GO:0038180)2.96331687
60sleep (GO:0030431)2.94450659
61positive regulation of catecholamine secretion (GO:0033605)2.93279529
62neurotransmitter secretion (GO:0007269)2.92404908
63positive regulation of granulocyte differentiation (GO:0030854)2.91208409
64epithelial cell differentiation involved in kidney development (GO:0035850)2.89592196
65regulation of vasculogenesis (GO:2001212)2.88196781
66purine nucleotide salvage (GO:0032261)2.86000263
67synaptic transmission, glutamatergic (GO:0035249)2.84179141
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83814180
69neuron-neuron synaptic transmission (GO:0007270)2.83387716
70proline transport (GO:0015824)2.82779064
71parental behavior (GO:0060746)2.79144295
72regulation of neurotransmitter secretion (GO:0046928)2.79007882
73regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.78178290
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71963479
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.71317460
76regulation of Rap GTPase activity (GO:0032317)2.70920749
77positive regulation of mast cell degranulation (GO:0043306)2.69830160
78positive regulation of mast cell activation involved in immune response (GO:0033008)2.69830160
79regulation of glutamate receptor signaling pathway (GO:1900449)2.68062927
80maternal behavior (GO:0042711)2.67319522
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65301714
82regulation of exocytosis (GO:0017157)2.62512522
83regulation of neuronal synaptic plasticity (GO:0048168)2.61987022
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61809342
85negative regulation of cation channel activity (GO:2001258)2.60160525
86regulation of neurotransmitter transport (GO:0051588)2.59915490
87valine metabolic process (GO:0006573)2.58586157
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.58341834
89regulation of platelet aggregation (GO:0090330)2.56649671
90multicellular organismal reproductive behavior (GO:0033057)2.55158069
91embryonic heart tube development (GO:0035050)2.53659464
92negative regulation of smooth muscle contraction (GO:0045986)2.53057542
93vesicle docking involved in exocytosis (GO:0006904)2.52128114
94energy homeostasis (GO:0097009)2.52045751
95astrocyte development (GO:0014002)2.50707597
96positive regulation of muscle cell apoptotic process (GO:0010661)2.50667394
97positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.50028291
98long term synaptic depression (GO:0060292)2.50002846
99phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49699084
100inositol phosphate dephosphorylation (GO:0046855)2.49699084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.80762053
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.90763985
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.25637108
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.23417898
5IGF1R_20145208_ChIP-Seq_DFB_Human3.04095121
6GATA1_22025678_ChIP-Seq_K562_Human2.94464465
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79092120
8GBX2_23144817_ChIP-Seq_PC3_Human2.74464831
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.35333897
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28329264
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.13068743
12VDR_22108803_ChIP-Seq_LS180_Human2.06893011
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01979451
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00682833
15REST_21632747_ChIP-Seq_MESCs_Mouse2.00206615
16GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.99076466
17FUS_26573619_Chip-Seq_HEK293_Human1.99002869
18DROSHA_22980978_ChIP-Seq_HELA_Human1.91971775
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91165168
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90834341
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90715415
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83183013
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76610874
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76303133
25LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.75489312
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69217824
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68970215
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68486419
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.59924478
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.55340104
31EZH2_22144423_ChIP-Seq_EOC_Human1.54878386
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51125228
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.51069422
34VDR_24763502_ChIP-Seq_THP-1_Human1.46138186
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45402961
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42564062
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42564062
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.41768860
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41362606
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40859727
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36998142
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35249601
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.34392846
44FLI1_21867929_ChIP-Seq_TH2_Mouse1.33518526
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32403052
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29490835
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29490835
48TAF15_26573619_Chip-Seq_HEK293_Human1.26145287
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25493180
50VDR_21846776_ChIP-Seq_THP-1_Human1.24949240
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24358332
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23916477
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.22759865
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.19531579
55RNF2_27304074_Chip-Seq_NSC_Mouse1.17463727
56TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16580565
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.16283495
58ETS1_22383799_ChIP-Seq_G1ME_Mouse1.12219879
59ER_23166858_ChIP-Seq_MCF-7_Human1.10794626
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10467528
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10089141
62GATA1_19941826_ChIP-Seq_K562_Human1.09065455
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.05940199
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05019468
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04239433
66VDR_24787735_ChIP-Seq_THP-1_Human1.04081680
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02029174
68TP53_22573176_ChIP-Seq_HFKS_Human1.01996473
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01388186
70MYB_26560356_Chip-Seq_TH2_Human1.01219798
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00821789
72DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97430910
73P300_19829295_ChIP-Seq_ESCs_Human0.96688130
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95334488
75HTT_18923047_ChIP-ChIP_STHdh_Human0.93237384
76SMAD4_21799915_ChIP-Seq_A2780_Human0.92403621
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92363898
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90961319
79ZNF274_21170338_ChIP-Seq_K562_Hela0.90522562
80EWS_26573619_Chip-Seq_HEK293_Human0.90447087
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89587504
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88862511
83CBP_20019798_ChIP-Seq_JUKART_Human0.87382228
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87382228
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86720903
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86656962
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85364589
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84803167
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83723455
90NANOG_19829295_ChIP-Seq_ESCs_Human0.83318562
91SOX2_19829295_ChIP-Seq_ESCs_Human0.83318562
92TAL1_26923725_Chip-Seq_HPCs_Mouse0.83164914
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80704747
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80615571
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.80609385
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.79482822
97TCF4_23295773_ChIP-Seq_U87_Human0.79131725
98RUNX_20019798_ChIP-Seq_JUKART_Human0.79007912
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.76813150
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.75916298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.55717052
2MP0004859_abnormal_synaptic_plasticity3.31556882
3MP0005646_abnormal_pituitary_gland3.14995732
4MP0002396_abnormal_hematopoietic_system3.13641887
5MP0001545_abnormal_hematopoietic_system3.02879656
6MP0005397_hematopoietic_system_phenotyp3.02879656
7MP0004808_abnormal_hematopoietic_stem2.87986761
8MP0009278_abnormal_bone_marrow2.86395134
9MP0000465_gastrointestinal_hemorrhage2.59790857
10MP0003635_abnormal_synaptic_transmissio2.58769554
11MP0001501_abnormal_sleep_pattern2.49155551
12MP0006292_abnormal_olfactory_placode2.46060237
13MP0001968_abnormal_touch/_nociception2.44231083
14MP0003183_abnormal_peptide_metabolism2.42003897
15MP0005464_abnormal_platelet_physiology2.39987197
16MP0009745_abnormal_behavioral_response2.20727125
17MP0002735_abnormal_chemical_nociception2.19815651
18MP0005084_abnormal_gallbladder_morpholo2.11785927
19MP0000681_abnormal_thyroid_gland2.11514134
20MP0002064_seizures2.10693266
21MP0001664_abnormal_digestion2.01053120
22MP0009379_abnormal_foot_pigmentation1.94194962
23MP0009046_muscle_twitch1.90740219
24MP0002272_abnormal_nervous_system1.82403286
25MP0002063_abnormal_learning/memory/cond1.81091475
26MP0002572_abnormal_emotion/affect_behav1.80783131
27MP0003172_abnormal_lysosome_physiology1.78279298
28MP0001486_abnormal_startle_reflex1.73458368
29MP0003806_abnormal_nucleotide_metabolis1.70621626
30MP0001905_abnormal_dopamine_level1.67932312
31MP0004147_increased_porphyrin_level1.62846948
32MP0010386_abnormal_urinary_bladder1.59146819
33MP0003633_abnormal_nervous_system1.54155047
34MP0009697_abnormal_copulation1.53316895
35MP0004270_analgesia1.52677727
36MP0002733_abnormal_thermal_nociception1.52566379
37MP0005645_abnormal_hypothalamus_physiol1.48839955
38MP0001970_abnormal_pain_threshold1.41948983
39MP0006276_abnormal_autonomic_nervous1.40553248
40MP0008872_abnormal_physiological_respon1.38841009
41MP0005423_abnormal_somatic_nervous1.38295641
42MP0003787_abnormal_imprinting1.37754811
43MP0003075_altered_response_to1.35461125
44MP0008569_lethality_at_weaning1.35124451
45MP0000013_abnormal_adipose_tissue1.33959311
46MP0002734_abnormal_mechanical_nocicepti1.32250006
47MP0005535_abnormal_body_temperature1.27896880
48MP0004484_altered_response_of1.25203078
49MP0001188_hyperpigmentation1.24936085
50MP0002160_abnormal_reproductive_system1.20670393
51MP0005670_abnormal_white_adipose1.19781715
52MP0005410_abnormal_fertilization1.18947768
53MP0003303_peritoneal_inflammation1.16650290
54MP0003656_abnormal_erythrocyte_physiolo1.11818951
55MP0001986_abnormal_taste_sensitivity1.05051835
56MP0002736_abnormal_nociception_after1.04592905
57MP0003763_abnormal_thymus_physiology1.02494261
58MP0002067_abnormal_sensory_capabilities1.01364043
59MP0003631_nervous_system_phenotype0.99337765
60MP0002557_abnormal_social/conspecific_i0.96704213
61MP0004924_abnormal_behavior0.94681061
62MP0005386_behavior/neurological_phenoty0.94681061
63MP0008874_decreased_physiological_sensi0.90977647
64MP0001502_abnormal_circadian_rhythm0.90596342
65MP0005165_increased_susceptibility_to0.88815388
66MP0002822_catalepsy0.88671617
67MP0002234_abnormal_pharynx_morphology0.88583028
68MP0003283_abnormal_digestive_organ0.87558154
69MP0000631_abnormal_neuroendocrine_gland0.86458511
70MP0005174_abnormal_tail_pigmentation0.86130562
71MP0001440_abnormal_grooming_behavior0.81921173
72MP0002148_abnormal_hypersensitivity_rea0.81625320
73MP0002229_neurodegeneration0.80966900
74MP0002928_abnormal_bile_duct0.80405606
75MP0005075_abnormal_melanosome_morpholog0.78664910
76MP0005551_abnormal_eye_electrophysiolog0.78285175
77MP0004811_abnormal_neuron_physiology0.75544775
78MP0004885_abnormal_endolymph0.73956215
79MP0008058_abnormal_DNA_repair0.73643497
80MP0001764_abnormal_homeostasis0.73376787
81MP0000230_abnormal_systemic_arterial0.72761196
82MP0001765_abnormal_ion_homeostasis0.72521431
83MP0005220_abnormal_exocrine_pancreas0.70770483
84MP0002398_abnormal_bone_marrow0.70317687
85MP0002066_abnormal_motor_capabilities/c0.68137938
86MP0000689_abnormal_spleen_morphology0.67659883
87MP0000920_abnormal_myelination0.67228692
88MP0000383_abnormal_hair_follicle0.67116910
89MP0002876_abnormal_thyroid_physiology0.65575454
90MP0003943_abnormal_hepatobiliary_system0.65122153
91MP0008961_abnormal_basal_metabolism0.65079292
92MP0003724_increased_susceptibility_to0.63600239
93MP0000015_abnormal_ear_pigmentation0.63227762
94MP0006036_abnormal_mitochondrial_physio0.62428594
95MP0004134_abnormal_chest_morphology0.61816627
96MP0008875_abnormal_xenobiotic_pharmacok0.61715874
97MP0008004_abnormal_stomach_pH0.61635836
98MP0002083_premature_death0.60642245
99MP0000569_abnormal_digit_pigmentation0.60129121
100MP0002693_abnormal_pancreas_physiology0.60009303

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.72402913
2Acute lymphatic leukemia (HP:0006721)4.55747784
3Febrile seizures (HP:0002373)4.35036806
4Focal motor seizures (HP:0011153)4.27992617
5Papilledema (HP:0001085)4.22772828
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.90137931
7Hyperthyroidism (HP:0000836)3.87874191
8Focal seizures (HP:0007359)3.73005682
9Metaphyseal dysplasia (HP:0100255)3.48161096
10Atonic seizures (HP:0010819)3.45287808
11Prolonged bleeding time (HP:0003010)3.29246159
12Action tremor (HP:0002345)3.28946820
13Annular pancreas (HP:0001734)3.27888960
14Diplopia (HP:0000651)3.27109013
15Abnormality of binocular vision (HP:0011514)3.27109013
16Progressive cerebellar ataxia (HP:0002073)3.21988253
17Decreased central vision (HP:0007663)3.10129727
18Genetic anticipation (HP:0003743)2.96236345
19Acute myeloid leukemia (HP:0004808)2.93674128
20Abnormal rod and cone electroretinograms (HP:0008323)2.91294208
21Epileptic encephalopathy (HP:0200134)2.91293657
22Attenuation of retinal blood vessels (HP:0007843)2.86708961
23Lower limb asymmetry (HP:0100559)2.86383531
24Microvesicular hepatic steatosis (HP:0001414)2.82592771
25Tetraplegia (HP:0002445)2.69126478
26Panhypogammaglobulinemia (HP:0003139)2.66625567
27Abnormality of B cell number (HP:0010975)2.65460626
28Visual hallucinations (HP:0002367)2.63599562
29Dyschromatopsia (HP:0007641)2.62133555
30Agammaglobulinemia (HP:0004432)2.52604002
31Central scotoma (HP:0000603)2.49651241
32Dysdiadochokinesis (HP:0002075)2.47573814
33Impaired smooth pursuit (HP:0007772)2.45987772
34Abnormality of the corticospinal tract (HP:0002492)2.45982748
35Ketoacidosis (HP:0001993)2.43759850
36Abnormality of ocular smooth pursuit (HP:0000617)2.42941704
37Epistaxis (HP:0000421)2.40716354
38Abnormal eating behavior (HP:0100738)2.39184487
39Stomatitis (HP:0010280)2.37133412
40Truncus arteriosus (HP:0001660)2.34942575
41Elevated erythrocyte sedimentation rate (HP:0003565)2.34312775
42Dyskinesia (HP:0100660)2.32493418
43Dicarboxylic aciduria (HP:0003215)2.30414764
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30414764
45B lymphocytopenia (HP:0010976)2.27436213
46Abnormality of macular pigmentation (HP:0008002)2.21615776
47Impaired vibratory sensation (HP:0002495)2.21034307
48Hemiparesis (HP:0001269)2.20495273
49Abnormality of saccadic eye movements (HP:0000570)2.20375335
50Thrombocytosis (HP:0001894)2.20229475
51Absence seizures (HP:0002121)2.19024294
52Gaze-evoked nystagmus (HP:0000640)2.18319995
53Ketosis (HP:0001946)2.17857709
54Amyotrophic lateral sclerosis (HP:0007354)2.16781771
55Spastic gait (HP:0002064)2.15615305
56Cerebral hypomyelination (HP:0006808)2.15368790
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15102712
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.15102712
59Severe visual impairment (HP:0001141)2.14889099
60Obstructive lung disease (HP:0006536)2.12064755
61Chronic obstructive pulmonary disease (HP:0006510)2.12064755
62Delusions (HP:0000746)2.11504364
63Methylmalonic aciduria (HP:0012120)2.10054066
64Methylmalonic acidemia (HP:0002912)2.09529168
65Scanning speech (HP:0002168)2.09509489
66Bundle branch block (HP:0011710)2.09011781
67Poor eye contact (HP:0000817)2.08910854
68Aplastic anemia (HP:0001915)2.08160287
69Abnormal number of erythroid precursors (HP:0012131)2.07801693
70Abnormality of cells of the erythroid lineage (HP:0012130)2.07152747
71Aplasia/Hypoplasia of the thymus (HP:0010515)2.05384350
72Constricted visual fields (HP:0001133)2.00737356
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.00543060
74Dialeptic seizures (HP:0011146)1.98619108
75Abnormal hemoglobin (HP:0011902)1.98467096
76Dysmetria (HP:0001310)1.96472672
77Cellulitis (HP:0100658)1.93193854
78Seborrheic dermatitis (HP:0001051)1.90112773
79Neurodegeneration (HP:0002180)1.89913463
80Autoimmune hemolytic anemia (HP:0001890)1.89648677
81Slow saccadic eye movements (HP:0000514)1.88811531
82Pallor (HP:0000980)1.88615476
83Abnormality of the prostate (HP:0008775)1.86422038
84Macular degeneration (HP:0000608)1.83400066
85Impaired vibration sensation in the lower limbs (HP:0002166)1.83174658
86Postural instability (HP:0002172)1.82067722
87Abnormal pupillary function (HP:0007686)1.81557733
88Ankle clonus (HP:0011448)1.81331902
89Progressive visual loss (HP:0000529)1.77737065
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76027302
91Urinary bladder sphincter dysfunction (HP:0002839)1.75354899
92Pigmentary retinal degeneration (HP:0001146)1.75145157
93Neonatal respiratory distress (HP:0002643)1.75056826
94Intention tremor (HP:0002080)1.74346750
95Petechiae (HP:0000967)1.73515547
96Sensory axonal neuropathy (HP:0003390)1.73349949
97Episodic fever (HP:0001954)1.68919678
98Abnormal platelet function (HP:0011869)1.68125952
99Impaired platelet aggregation (HP:0003540)1.68125952
100Epileptiform EEG discharges (HP:0011182)1.67994329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.79841791
2DAPK24.10657870
3PINK13.70844208
4PRKG23.35629776
5TAOK33.16632667
6NUAK12.77563933
7EPHA42.60272632
8KIT2.51680080
9NME22.16978118
10MAP3K61.85014960
11FLT31.82316222
12PAK61.79420131
13MAP2K61.77750354
14INSRR1.71165997
15PBK1.70676799
16FES1.62272224
17TEC1.61316196
18NTRK31.58505591
19DAPK11.58433628
20LATS11.53125771
21MAP2K31.38004914
22SYK1.36682992
23RPS6KB21.33565151
24SCYL21.32501003
25CAMKK11.28266878
26BMPR21.25370709
27TNK21.24919257
28MAP4K21.20899973
29MINK11.15730334
30EIF2AK31.15692442
31MAP2K41.14282304
32FRK1.11853544
33GRK51.09007140
34JAK31.02345146
35PRKCH1.00124861
36UHMK10.95248740
37MATK0.93162668
38RIPK40.92552279
39PRKCQ0.89643847
40MAPKAPK50.89460475
41BTK0.88112041
42CDK190.87892598
43IKBKB0.84990455
44TXK0.83796405
45MAP3K10.81797092
46PIK3CG0.81124037
47TBK10.79026325
48CAMK10.78583421
49CCNB10.77712400
50MKNK10.77632428
51PLK20.77545917
52GRK60.75633988
53CAMKK20.73152544
54STK380.73151281
55RPS6KC10.72141685
56RPS6KL10.72141685
57STK110.71842526
58RPS6KA60.70133641
59RET0.69109746
60MAPK70.68816520
61MAP3K110.68285199
62CDK30.65343827
63PRKD20.64195883
64MAPK130.63866741
65ITK0.63383558
66PRKD30.62325843
67PTK2B0.60866064
68DAPK30.60504657
69PAK20.59425752
70RPS6KB10.59238565
71RAF10.55901985
72DYRK1A0.55495665
73PRKCG0.53068408
74PHKG20.51956532
75PHKG10.51956532
76MAP4K10.50576808
77PRKCE0.50028785
78MAPK30.48286243
79CAMK2A0.48285774
80LCK0.47683406
81PRKCA0.44683492
82RPS6KA30.43892629
83CLK10.43655244
84ZAP700.42586544
85VRK10.42525457
86CAMK2D0.42242938
87PRKCD0.42159878
88MAPK40.41520242
89MAP3K50.41190596
90TRPM70.40967299
91OXSR10.40168988
92ADRBK10.39628020
93RPS6KA50.39335556
94MAP2K20.39050590
95PIK3CA0.38480695
96CSNK1G20.38382196
97CDK90.37020839
98CAMK2B0.36800984
99PDK10.36196683
100FYN0.35579294

Predicted pathways (KEGG)

RankGene SetZ-score
1Salivary secretion_Homo sapiens_hsa049703.03456456
2Renin secretion_Homo sapiens_hsa049242.99238234
3Circadian entrainment_Homo sapiens_hsa047132.69362657
4Nicotine addiction_Homo sapiens_hsa050332.64252948
5Long-term depression_Homo sapiens_hsa047302.56263146
6Olfactory transduction_Homo sapiens_hsa047402.42953068
7Platelet activation_Homo sapiens_hsa046112.40617643
8Synaptic vesicle cycle_Homo sapiens_hsa047212.34388945
9Long-term potentiation_Homo sapiens_hsa047202.29697159
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.17016067
11Amphetamine addiction_Homo sapiens_hsa050312.13094022
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.97593788
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88919957
14Insulin secretion_Homo sapiens_hsa049111.84818219
15Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.80682169
16Morphine addiction_Homo sapiens_hsa050321.79965565
17Glutamatergic synapse_Homo sapiens_hsa047241.78405028
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78325541
19Taste transduction_Homo sapiens_hsa047421.77737116
20Calcium signaling pathway_Homo sapiens_hsa040201.76258884
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74566816
22Oxytocin signaling pathway_Homo sapiens_hsa049211.72973953
23GABAergic synapse_Homo sapiens_hsa047271.59064907
24Dopaminergic synapse_Homo sapiens_hsa047281.58692671
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51738165
26Pancreatic secretion_Homo sapiens_hsa049721.48554450
27Gastric acid secretion_Homo sapiens_hsa049711.48520035
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.47560711
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45160631
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42762569
31Cocaine addiction_Homo sapiens_hsa050301.39879517
32Serotonergic synapse_Homo sapiens_hsa047261.38336315
33Phototransduction_Homo sapiens_hsa047441.35262808
34Gap junction_Homo sapiens_hsa045401.35038345
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28255349
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27465515
37Cholinergic synapse_Homo sapiens_hsa047251.27138580
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23415344
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22100822
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18703995
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13099211
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.11455374
43cAMP signaling pathway_Homo sapiens_hsa040241.07579858
44Ribosome_Homo sapiens_hsa030101.07259640
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02635675
46Inositol phosphate metabolism_Homo sapiens_hsa005620.99388115
47Butanoate metabolism_Homo sapiens_hsa006500.98072036
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92916763
49Propanoate metabolism_Homo sapiens_hsa006400.88996852
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88736744
51Dorso-ventral axis formation_Homo sapiens_hsa043200.88186945
52Asthma_Homo sapiens_hsa053100.86776633
53Ether lipid metabolism_Homo sapiens_hsa005650.84747721
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84665689
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82616269
56Arachidonic acid metabolism_Homo sapiens_hsa005900.81795976
57African trypanosomiasis_Homo sapiens_hsa051430.80388744
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78642443
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75889280
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.73293703
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67937842
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.67788251
63Circadian rhythm_Homo sapiens_hsa047100.67401194
64Other glycan degradation_Homo sapiens_hsa005110.66019884
65Peroxisome_Homo sapiens_hsa041460.65726199
66Purine metabolism_Homo sapiens_hsa002300.64638411
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62317373
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62282838
69Ovarian steroidogenesis_Homo sapiens_hsa049130.61350942
70MAPK signaling pathway_Homo sapiens_hsa040100.61274275
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56455466
72B cell receptor signaling pathway_Homo sapiens_hsa046620.56438092
73Glucagon signaling pathway_Homo sapiens_hsa049220.54064339
74Linoleic acid metabolism_Homo sapiens_hsa005910.53670244
75Collecting duct acid secretion_Homo sapiens_hsa049660.53418196
76Base excision repair_Homo sapiens_hsa034100.51331949
77Pentose phosphate pathway_Homo sapiens_hsa000300.50858577
78GnRH signaling pathway_Homo sapiens_hsa049120.49957570
79Estrogen signaling pathway_Homo sapiens_hsa049150.49006678
80Type I diabetes mellitus_Homo sapiens_hsa049400.47086272
81Type II diabetes mellitus_Homo sapiens_hsa049300.44189949
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44181263
83Thyroid hormone synthesis_Homo sapiens_hsa049180.41155970
84Lysosome_Homo sapiens_hsa041420.40454723
85Nitrogen metabolism_Homo sapiens_hsa009100.39111107
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38227146
87Acute myeloid leukemia_Homo sapiens_hsa052210.37697889
88mTOR signaling pathway_Homo sapiens_hsa041500.37541333
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.37057506
90Oocyte meiosis_Homo sapiens_hsa041140.36467459
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.34785917
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34153279
93VEGF signaling pathway_Homo sapiens_hsa043700.33660198
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33607141
95Fatty acid elongation_Homo sapiens_hsa000620.31491262
96Alcoholism_Homo sapiens_hsa050340.31238518
97Regulation of autophagy_Homo sapiens_hsa041400.30952362
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30794833
99Glioma_Homo sapiens_hsa052140.30721515
100N-Glycan biosynthesis_Homo sapiens_hsa005100.30011558

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