ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	omega-hydroxylase P450 pathway (GO:0097267)	9.98949560
2	epoxygenase P450 pathway (GO:0019373)	9.88056636
3	exogenous drug catabolic process (GO:0042738)	9.68307542
4	complement activation, alternative pathway (GO:0006957)	9.31458410
5	drug catabolic process (GO:0042737)	9.20819548
6	glyoxylate metabolic process (GO:0046487)	8.32163697
7	L-phenylalanine catabolic process (GO:0006559)	8.18904877
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	8.18904877
9	regulation of fibrinolysis (GO:0051917)	8.17597337
10	regulation of protein activation cascade (GO:2000257)	8.06520567
11	ethanol oxidation (GO:0006069)	7.75538393
12	regulation of complement activation (GO:0030449)	7.70135731
13	L-phenylalanine metabolic process (GO:0006558)	7.43070427
14	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.43070427
15	negative regulation of fibrinolysis (GO:0051918)	7.29497367
16	protein carboxylation (GO:0018214)	6.60913245
17	peptidyl-glutamic acid carboxylation (GO:0017187)	6.60913245
18	urea metabolic process (GO:0019627)	6.55255100
19	imidazole-containing compound metabolic process (GO:0052803)	6.55246553
20	drug metabolic process (GO:0017144)	6.49070544
21	fibrinolysis (GO:0042730)	6.28658502
22	ethanol metabolic process (GO:0006067)	6.20659301
23	oxidative demethylation (GO:0070989)	6.15724748
24	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.12415817
25	aromatic amino acid family catabolic process (GO:0009074)	6.09866060
26	serine family amino acid catabolic process (GO:0009071)	6.04589322
27	blood coagulation, intrinsic pathway (GO:0007597)	6.00416337
28	nitrogen cycle metabolic process (GO:0071941)	5.96817062
29	opsonization (GO:0008228)	5.84302985
30	regulation of triglyceride catabolic process (GO:0010896)	5.68518800
31	protein activation cascade (GO:0072376)	5.68210399
32	urea cycle (GO:0000050)	5.60224057
33	complement activation (GO:0006956)	5.56775307
34	bile acid biosynthetic process (GO:0006699)	5.55926692
35	regulation of plasminogen activation (GO:0010755)	5.49797843
36	negative regulation of cholesterol transport (GO:0032375)	5.43206920
37	negative regulation of sterol transport (GO:0032372)	5.43206920
38	complement activation, classical pathway (GO:0006958)	5.40076861
39	cellular glucuronidation (GO:0052695)	5.29061367
40	glycine metabolic process (GO:0006544)	5.13584962
41	phenylpropanoid metabolic process (GO:0009698)	5.05002488
42	glucuronate metabolic process (GO:0019585)	5.02752224
43	uronic acid metabolic process (GO:0006063)	5.02752224
44	tyrosine metabolic process (GO:0006570)	5.01765550
45	acute-phase response (GO:0006953)	4.98181088
46	bile acid metabolic process (GO:0008206)	4.92793267
47	regulation of humoral immune response (GO:0002920)	4.91686170
48	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	4.83176489
49	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	4.83176489
50	glutamate metabolic process (GO:0006536)	4.82371246
51	S-adenosylmethionine metabolic process (GO:0046500)	4.82020856
52	negative regulation of protein activation cascade (GO:2000258)	4.76767381
53	cytolysis (GO:0019835)	4.76026913
54	negative regulation of hemostasis (GO:1900047)	4.68432328
55	negative regulation of blood coagulation (GO:0030195)	4.68432328
56	positive regulation of triglyceride lipase activity (GO:0061365)	4.65987706
57	positive regulation of lipoprotein lipase activity (GO:0051006)	4.65987706
58	bile acid and bile salt transport (GO:0015721)	4.60092213
59	triglyceride homeostasis (GO:0070328)	4.55661278
60	acylglycerol homeostasis (GO:0055090)	4.55661278
61	protein-lipid complex remodeling (GO:0034368)	4.37549002
62	macromolecular complex remodeling (GO:0034367)	4.37549002
63	plasma lipoprotein particle remodeling (GO:0034369)	4.37549002
64	alkaloid metabolic process (GO:0009820)	4.35438386
65	alpha-amino acid catabolic process (GO:1901606)	4.27045178
66	negative regulation of coagulation (GO:0050819)	4.24669659
67	tryptophan catabolic process (GO:0006569)	4.24053779
68	indole-containing compound catabolic process (GO:0042436)	4.24053779
69	indolalkylamine catabolic process (GO:0046218)	4.24053779
70	negative regulation of wound healing (GO:0061045)	4.21606711
71	serine family amino acid metabolic process (GO:0009069)	4.12035987
72	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.10986370
73	cholesterol efflux (GO:0033344)	4.08389936
74	high-density lipoprotein particle remodeling (GO:0034375)	4.07152935
75	phospholipid efflux (GO:0033700)	4.05451124
76	positive regulation of blood coagulation (GO:0030194)	4.03876775
77	positive regulation of hemostasis (GO:1900048)	4.03876775
78	aromatic amino acid family metabolic process (GO:0009072)	3.98727357
79	cellular ketone body metabolic process (GO:0046950)	3.96668226
80	negative regulation of complement activation (GO:0045916)	3.91139804
81	reverse cholesterol transport (GO:0043691)	3.77518151
82	arginine metabolic process (GO:0006525)	3.77320063
83	amino-acid betaine metabolic process (GO:0006577)	3.71440561
84	positive regulation of coagulation (GO:0050820)	3.69595096
85	acute inflammatory response (GO:0002526)	3.68529322
86	flavonoid metabolic process (GO:0009812)	3.68199726
87	serine family amino acid biosynthetic process (GO:0009070)	3.66486477
88	negative regulation of lipase activity (GO:0060192)	3.62593170
89	cellular amino acid catabolic process (GO:0009063)	3.62460917
90	positive regulation of lipid catabolic process (GO:0050996)	3.59963684
91	tryptophan metabolic process (GO:0006568)	3.57989537
92	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.57888084
93	regulation of cholesterol esterification (GO:0010872)	3.50979088
94	cysteine metabolic process (GO:0006534)	3.50144546
95	regulation of acute inflammatory response (GO:0002673)	3.48733463
96	ketone body metabolic process (GO:1902224)	3.48088019
97	xenobiotic metabolic process (GO:0006805)	3.45335466
98	aldehyde catabolic process (GO:0046185)	3.44516434
99	intestinal cholesterol absorption (GO:0030299)	3.44436205
100	response to mercury ion (GO:0046689)	3.44188634

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EGR1_23403033_ChIP-Seq_LIVER_Mouse	7.06060334
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.05617133
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.87227948
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.71816972
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.71425082
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.94766156
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.77627807
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.23541940
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.81609874
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.44564083
11	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.12906789
12	HTT_18923047_ChIP-ChIP_STHdh_Human	2.03501227
13	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.4945723
14	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.97233863
15	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.90399209
16	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.84690998
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58543766
18	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.47618234
19	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.36950277
20	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.34445729
21	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33543682
22	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.32164001
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.19338249
24	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.15299453
25	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.08492380
26	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.04608783
27	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04390084
28	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.02319709
29	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.98198440
30	BCAT_22108803_ChIP-Seq_LS180_Human	0.96216371
31	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.91568058
32	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.91460325
33	IRF1_19129219_ChIP-ChIP_H3396_Human	0.88258401
34	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.87982844
35	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.87811997
36	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.86113695
37	PHF8_20622853_ChIP-Seq_HELA_Human	0.84297345
38	CBP_21632823_ChIP-Seq_H3396_Human	0.81575075
39	AR_20517297_ChIP-Seq_VCAP_Human	0.80554615
40	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.80323806
41	GATA1_22025678_ChIP-Seq_K562_Human	0.76590112
42	LXR_22292898_ChIP-Seq_THP-1_Human	0.75503429
43	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.74852872
44	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.74838386
45	NFYA_21822215_ChIP-Seq_K562_Human	0.74306213
46	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.74218848
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.71262624
48	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.70723573
49	TP53_18474530_ChIP-ChIP_U2OS_Human	0.69782192
50	RAC3_21632823_ChIP-Seq_H3396_Human	0.68484903
51	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.67563802
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.67479299
53	CEBPB_22108803_ChIP-Seq_LS180_Human	0.67076955
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.66990346
55	GATA4_25053715_ChIP-Seq_YYC3_Human	0.66946446
56	MYC_19829295_ChIP-Seq_ESCs_Human	0.65370310
57	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.65195804
58	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.64457790
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.64060865
60	* SOX2_21211035_ChIP-Seq_LN229_Human	0.62989360
61	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.62358128
62	SPI1_20517297_ChIP-Seq_HL60_Human	0.61186078
63	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.61000033
64	ETV1_20927104_ChIP-Seq_GIST48_Human	0.60873522
65	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.60683877
66	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.58887760
67	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.58634960
68	TAF2_19829295_ChIP-Seq_ESCs_Human	0.58194683
69	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.57765285
70	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.56639674
71	P53_21459846_ChIP-Seq_SAOS-2_Human	0.56400223
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.55879388
73	SMC4_20622854_ChIP-Seq_HELA_Human	0.55602815
74	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.55599648
75	E2F1_20622854_ChIP-Seq_HELA_Human	0.55418544
76	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.54943615
77	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.54851789
78	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.54616057
79	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.54575490
80	ERG_20517297_ChIP-Seq_VCAP_Human	0.54487212
81	CTCF_27219007_Chip-Seq_Bcells_Human	0.54383201
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.53685345
83	NFYB_21822215_ChIP-Seq_K562_Human	0.53659734
84	MYC_19915707_ChIP-ChIP_AK7_Human	0.53530855
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.53311491
86	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.53100148
87	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.53075512
88	SA1_27219007_Chip-Seq_Bcells_Human	0.52469482
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.52447791
90	CTCF_20526341_ChIP-Seq_ESCs_Human	0.51824599
91	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.49691614
92	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.48789319
93	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.47791507
94	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.47229873
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.46922582
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.46780707
97	ER_23166858_ChIP-Seq_MCF-7_Human	0.46018306
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.46013276
99	RBPJ_21746931_ChIP-Seq_IB4_Human	0.45422968
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.44789228

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.65132397
2	MP0008875_abnormal_xenobiotic_pharmacok	6.36151902
3	MP0005360_urolithiasis	6.23287583
4	MP0005085_abnormal_gallbladder_physiolo	6.20728472
5	MP0005365_abnormal_bile_salt	5.33053742
6	MP0003195_calcinosis	5.30504493
7	MP0002138_abnormal_hepatobiliary_system	4.28447642
8	MP0003252_abnormal_bile_duct	4.05420580
9	MP0001666_abnormal_nutrient_absorption	3.06826488
10	MP0010329_abnormal_lipoprotein_level	2.95689186
11	MP0003191_abnormal_cellular_cholesterol	2.86579042
12	MP0003868_abnormal_feces_composition	2.75870490
13	MP0009697_abnormal_copulation	2.44820163
14	MP0005332_abnormal_amino_acid	2.41570423
15	MP0010368_abnormal_lymphatic_system	2.25744816
16	MP0003806_abnormal_nucleotide_metabolis	2.24690233
17	MP0000609_abnormal_liver_physiology	1.89413769
18	MP0002876_abnormal_thyroid_physiology	1.81992400
19	MP0002118_abnormal_lipid_homeostasis	1.72361401
20	MP0009840_abnormal_foam_cell	1.71001122
21	MP0005670_abnormal_white_adipose	1.58742846
22	MP0001764_abnormal_homeostasis	1.55439823
23	MP0002132_abnormal_respiratory_system	1.39646871
24	MP0003656_abnormal_erythrocyte_physiolo	1.30025443
25	MP0009053_abnormal_anal_canal	1.27632620
26	MP0001661_extended_life_span	1.26640769
27	MP0009764_decreased_sensitivity_to	1.20302797
28	MP0004019_abnormal_vitamin_homeostasis	1.17264840
29	MP0005319_abnormal_enzyme/_coenzyme	1.09513630
30	MP0005408_hypopigmentation	1.08175850
31	MP0000598_abnormal_liver_morphology	1.07935245
32	MP0002282_abnormal_trachea_morphology	1.07527819
33	MP0009763_increased_sensitivity_to	1.00916636
34	MP0008872_abnormal_physiological_respon	0.99074669
35	MP0005584_abnormal_enzyme/coenzyme_acti	0.98612227
36	MP0009643_abnormal_urine_homeostasis	0.94660557
37	MP0002971_abnormal_brown_adipose	0.92902123
38	MP0005451_abnormal_body_composition	0.90178005
39	MP0009642_abnormal_blood_homeostasis	0.86849873
40	MP0008469_abnormal_protein_level	0.83108455
41	MP0005376_homeostasis/metabolism_phenot	0.83082767
42	MP0002249_abnormal_larynx_morphology	0.82378018
43	MP0000604_amyloidosis	0.78959559
44	MP0005535_abnormal_body_temperature	0.77280991
45	MP0001915_intracranial_hemorrhage	0.77224843
46	MP0003879_abnormal_hair_cell	0.73191131
47	MP0003186_abnormal_redox_activity	0.72802798
48	MP0005266_abnormal_metabolism	0.72085251
49	MP0005395_other_phenotype	0.71823941
50	MP0003690_abnormal_glial_cell	0.70650774
51	MP0005636_abnormal_mineral_homeostasis	0.70064823
52	MP0009785_altered_susceptibility_to	0.68958347
53	MP0002168_other_aberrant_phenotype	0.68631294
54	MP0005187_abnormal_penis_morphology	0.66653794
55	MP0008874_decreased_physiological_sensi	0.65175377
56	MP0004130_abnormal_muscle_cell	0.65120715
57	MP0005334_abnormal_fat_pad	0.63452557
58	MP0009765_abnormal_xenobiotic_induced	0.63122607
59	MP0002078_abnormal_glucose_homeostasis	0.61549394
60	MP0004782_abnormal_surfactant_physiolog	0.61082008
61	MP0005464_abnormal_platelet_physiology	0.59906292
62	MP0005166_decreased_susceptibility_to	0.58323262
63	MP0003011_delayed_dark_adaptation	0.56423805
64	MP0003075_altered_response_to	0.52751514
65	MP0002332_abnormal_exercise_endurance	0.52725908
66	MP0005023_abnormal_wound_healing	0.49994864
67	MP0003638_abnormal_response/metabolism_	0.48092342
68	MP0000467_abnormal_esophagus_morphology	0.42942068
69	MP0006292_abnormal_olfactory_placode	0.41428541
70	MP0000249_abnormal_blood_vessel	0.41057446
71	MP0003705_abnormal_hypodermis_morpholog	0.37333285
72	MP0005448_abnormal_energy_balance	0.37135160
73	MP0006036_abnormal_mitochondrial_physio	0.36403534
74	MP0001986_abnormal_taste_sensitivity	0.34735964
75	MP0001545_abnormal_hematopoietic_system	0.33455885
76	MP0005397_hematopoietic_system_phenotyp	0.33455885
77	MP0004883_abnormal_blood_vessel	0.32554214
78	MP0002136_abnormal_kidney_physiology	0.32006252
79	MP0005164_abnormal_response_to	0.30786626
80	MP0009115_abnormal_fat_cell	0.30166495
81	MP0000566_synostosis	0.29871829
82	MP0003953_abnormal_hormone_level	0.29383954
83	MP0000639_abnormal_adrenal_gland	0.29383778
84	MP0001845_abnormal_inflammatory_respons	0.24968521
85	MP0003436_decreased_susceptibility_to	0.23854054
86	MP0005647_abnormal_sex_gland	0.23312011
87	MP0005666_abnormal_adipose_tissue	0.23193848
88	MP0001851_eye_inflammation	0.22384595
89	MP0005220_abnormal_exocrine_pancreas	0.20643535
90	MP0002128_abnormal_blood_circulation	0.19743196
91	MP0005058_abnormal_lysosome_morphology	0.19696643
92	MP0002970_abnormal_white_adipose	0.19031218
93	MP0001881_abnormal_mammary_gland	0.18968631
94	MP0008873_increased_physiological_sensi	0.18545917
95	MP0003718_maternal_effect	0.18235730
96	MP0010155_abnormal_intestine_physiology	0.18074345
97	MP0005083_abnormal_biliary_tract	0.17410073
98	MP0002295_abnormal_pulmonary_circulatio	0.16239890
99	MP0003878_abnormal_ear_physiology	0.16213888
100	MP0005377_hearing/vestibular/ear_phenot	0.16213888

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	9.49132479
2	Prolonged partial thromboplastin time (HP:0003645)	9.36170645
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	9.04780177
4	Abnormality of complement system (HP:0005339)	8.72051006
5	Hypobetalipoproteinemia (HP:0003563)	7.47274032
6	Conjugated hyperbilirubinemia (HP:0002908)	6.72243302
7	Systemic lupus erythematosus (HP:0002725)	6.72185339
8	Joint hemorrhage (HP:0005261)	6.59523357
9	Hyperlipoproteinemia (HP:0010980)	6.33675753
10	Glomerulonephritis (HP:0000099)	5.44706177
11	Recurrent gram-negative bacterial infections (HP:0005420)	5.38148741
12	Xanthomatosis (HP:0000991)	4.99567922
13	Intrahepatic cholestasis (HP:0001406)	4.94207404
14	Abnormality of pyrimidine metabolism (HP:0004353)	4.87673192
15	Abnormality of the intrinsic pathway (HP:0010989)	4.50933490
16	Spontaneous abortion (HP:0005268)	4.48053269
17	Hypolipoproteinemia (HP:0010981)	4.42113050
18	Abnormality of the common coagulation pathway (HP:0010990)	4.30438421
19	Nephritis (HP:0000123)	4.03811256
20	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.90612237
21	Hypoalphalipoproteinemia (HP:0003233)	3.84901704
22	Abnormality of methionine metabolism (HP:0010901)	3.72169390
23	Neonatal hypoglycemia (HP:0001998)	3.37501592
24	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.24930886
25	Hyperglycinemia (HP:0002154)	3.22610982
26	Delayed CNS myelination (HP:0002188)	3.16262613
27	Fair hair (HP:0002286)	3.10794623
28	Hyperammonemia (HP:0001987)	2.99186630
29	Gingival bleeding (HP:0000225)	2.96112735
30	Fat malabsorption (HP:0002630)	2.81204776
31	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.81137953
32	Abnormality of glycine metabolism (HP:0010895)	2.79432721
33	Abnormality of serine family amino acid metabolism (HP:0010894)	2.79432721
34	Hypercholesterolemia (HP:0003124)	2.78921982
35	Thrombophlebitis (HP:0004418)	2.73032031
36	Generalized aminoaciduria (HP:0002909)	2.67557730
37	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.66621762
38	Abnormality of nucleobase metabolism (HP:0010932)	2.64478821
39	Mitral stenosis (HP:0001718)	2.60770075
40	Epidermoid cyst (HP:0200040)	2.60747302
41	Hemorrhage of the eye (HP:0011885)	2.58734725
42	Hyperbilirubinemia (HP:0002904)	2.55397798
43	Purpura (HP:0000979)	2.48531734
44	Abnormality of serum amino acid levels (HP:0003112)	2.47122513
45	Osteomalacia (HP:0002749)	2.45304999
46	Hepatocellular carcinoma (HP:0001402)	2.40470192
47	Vascular calcification (HP:0004934)	2.39414390
48	Pulmonary embolism (HP:0002204)	2.36428197
49	Menorrhagia (HP:0000132)	2.34383735
50	Rickets (HP:0002748)	2.23224999
51	Hyperglycinuria (HP:0003108)	2.21550862
52	Generalized hypopigmentation of hair (HP:0011358)	2.21438668
53	Ketosis (HP:0001946)	2.14516089
54	Cholelithiasis (HP:0001081)	2.13148450
55	Cardiovascular calcification (HP:0011915)	2.11907744
56	Steatorrhea (HP:0002570)	2.11820275
57	Metabolic acidosis (HP:0001942)	2.06585437
58	Cholecystitis (HP:0001082)	2.04145835
59	Abnormal gallbladder physiology (HP:0012438)	2.04145835
60	Complement deficiency (HP:0004431)	10.8304848
61	Abnormality of monocarboxylic acid metabolism (HP:0010996)	10.3046717
62	Abnormal gallbladder morphology (HP:0012437)	1.97622295
63	Abnormality of iron homeostasis (HP:0011031)	1.97183089
64	Blue irides (HP:0000635)	1.95608151
65	Increased serum ferritin (HP:0003281)	1.89625728
66	Elevated alkaline phosphatase (HP:0003155)	1.88872592
67	Reduced antithrombin III activity (HP:0001976)	1.88767313
68	Myocardial infarction (HP:0001658)	1.87391067
69	Joint swelling (HP:0001386)	1.87012087
70	Hyperphosphaturia (HP:0003109)	1.84304278
71	Epistaxis (HP:0000421)	1.82076304
72	Arthropathy (HP:0003040)	1.80746643
73	Gangrene (HP:0100758)	1.79996570
74	Increased mean platelet volume (HP:0011877)	1.79627663
75	Abnormal enzyme/coenzyme activity (HP:0012379)	1.76410172
76	Abnormality of transition element cation homeostasis (HP:0011030)	1.76272232
77	Abnormality of alkaline phosphatase activity (HP:0004379)	1.72458906
78	Cerebral palsy (HP:0100021)	1.72293945
79	Irritability (HP:0000737)	1.71517180
80	Atrioventricular block (HP:0001678)	1.70711272
81	Hypochromic microcytic anemia (HP:0004840)	1.66191008
82	Abnormality of vitamin metabolism (HP:0100508)	1.66085279
83	Gout (HP:0001997)	1.64490390
84	Abnormal platelet volume (HP:0011876)	1.63471169
85	Abnormality of purine metabolism (HP:0004352)	1.62181401
86	Reticulocytosis (HP:0001923)	1.60396200
87	Abnormality of the Achilles tendon (HP:0005109)	1.60216569
88	Skin nodule (HP:0200036)	1.59535232
89	Hypophosphatemic rickets (HP:0004912)	1.57281904
90	Pancreatitis (HP:0001733)	1.56054136
91	Glycosuria (HP:0003076)	1.55366120
92	Abnormality of urine glucose concentration (HP:0011016)	1.55366120
93	Poikilocytosis (HP:0004447)	1.55123751
94	Impaired platelet aggregation (HP:0003540)	1.54731996
95	Abnormal platelet function (HP:0011869)	1.54731996
96	Enlarged kidneys (HP:0000105)	1.52945270
97	Bifid scrotum (HP:0000048)	1.50543542
98	Lethargy (HP:0001254)	1.49855689
99	Bile duct proliferation (HP:0001408)	1.48939051
100	Abnormal biliary tract physiology (HP:0012439)	1.48939051

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	6.46178641
2	FGFR4	3.98018737
3	SIK1	3.58724522
4	TRIB3	3.56804259
5	PIK3CG	3.53070678
6	BCKDK	3.13878958
7	TYK2	2.86733455
8	RIPK1	2.39382021
9	PIK3CA	2.31027266
10	PRKACG	2.27076804
11	NTRK3	2.16254126
12	EPHA3	2.02197170
13	PRKAA2	1.96288766
14	TAOK3	1.87957173
15	MAP2K4	1.76616639
16	PRPF4B	1.75734440
17	TNK2	1.62879134
18	MAPK11	1.61353552
19	JAK1	1.48964513
20	KDR	1.48931322
21	MAP3K3	1.47328463
22	PRKCG	1.38499151
23	IGF1R	1.34405613
24	FGFR3	1.32455901
25	TIE1	1.27357324
26	ERBB2	1.24602097
27	PDPK1	1.23269874
28	BLK	1.17196448
29	NLK	1.16718193
30	CSF1R	1.12604846
31	NEK9	1.08000544
32	ABL2	1.07184527
33	JAK2	1.06203270
34	EPHB1	1.03462850
35	MAP3K13	1.00413813
36	TBK1	0.99964646
37	PRKG1	0.99217398
38	FER	0.97346695
39	PRKCZ	0.96932798
40	PKN2	0.96396598
41	CAMKK2	0.94625127
42	MAPK7	0.93841014
43	MAPK12	0.92567080
44	PRKACA	0.91755746
45	PDK2	0.91615718
46	DAPK2	0.88443491
47	FRK	0.86532336
48	PDK1	0.85996172
49	MST1R	0.85848911
50	MAP3K1	0.81697202
51	EPHA4	0.80571752
52	PRKAA1	0.80487183
53	INSRR	0.73333041
54	AKT3	0.73251203
55	MAP3K11	0.72380012
56	MAPK4	0.71165822
57	TAOK2	0.70497336
58	CAMKK1	0.70492346
59	KIT	0.66178222
60	RET	0.64096465
61	DYRK1B	0.61124743
62	IKBKE	0.61062217
63	TGFBR2	0.60664403
64	MYLK	0.59729887
65	RPS6KA3	0.57325778
66	PRKCA	0.56414916
67	PRKACB	0.55204343
68	CDK6	0.55143107
69	PRKCB	0.54686239
70	CSNK1D	0.52651270
71	PINK1	0.50944916
72	ARAF	0.50430834
73	ZAP70	0.49307470
74	MAP4K1	0.46636951
75	SRC	0.46507083
76	SGK223	0.45980099
77	SGK494	0.45980099
78	SGK1	0.43481006
79	CSNK1E	0.43321888
80	MAP3K6	0.42261647
81	MET	0.42084137
82	SGK2	0.41984995
83	GSK3A	0.40235783
84	CSNK2A1	0.39051996
85	SGK3	0.38618454
86	MAPK3	0.37977168
87	CAMK2G	0.37755916
88	MAPKAPK5	0.37051329
89	DYRK1A	0.36434287
90	WNK3	0.34864308
91	MAP3K2	0.34784709
92	ICK	0.33944375
93	MAP3K7	0.32214320
94	TXK	0.31129959
95	CSNK2A2	0.30319053
96	CDK4	0.29938053
97	MTOR	0.29778998
98	GRK1	0.29742243
99	CSNK1A1	0.28184003
100	MAP2K2	0.27848359

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.63681034
2	Caffeine metabolism_Homo sapiens_hsa00232	4.59346574
3	Complement and coagulation cascades_Homo sapiens_hsa04610	4.10369301
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.63653773
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.46540719
6	Retinol metabolism_Homo sapiens_hsa00830	3.41598063
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.08897819
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.91848470
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.86848495
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.84655490
11	Fatty acid degradation_Homo sapiens_hsa00071	2.66909238
12	Arginine biosynthesis_Homo sapiens_hsa00220	2.64270344
13	Tyrosine metabolism_Homo sapiens_hsa00350	2.63147459
14	Phenylalanine metabolism_Homo sapiens_hsa00360	2.59647100
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.37819949
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.34924711
17	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.29713462
18	Histidine metabolism_Homo sapiens_hsa00340	2.22296356
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.13328149
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96941593
21	Butanoate metabolism_Homo sapiens_hsa00650	1.84845802
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.80375646
23	Bile secretion_Homo sapiens_hsa04976	1.60553167
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59990546
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.58851856
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.55712482
27	Prion diseases_Homo sapiens_hsa05020	1.54245781
28	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.49394977
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39966573
30	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.39031600
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.38167811
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.31409608
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.23284465
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.22705273
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.20157716
36	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.19393558
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18336506
38	Peroxisome_Homo sapiens_hsa04146	1.14616641
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.09810199
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.04678463
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.01602040
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99584887
43	One carbon pool by folate_Homo sapiens_hsa00670	0.95513361
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.93727403
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.89751948
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88599676
47	Carbon metabolism_Homo sapiens_hsa01200	0.82266923
48	ABC transporters_Homo sapiens_hsa02010	0.76685168
49	Propanoate metabolism_Homo sapiens_hsa00640	0.71845178
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.67748667
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67423947
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.66823118
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.54879428
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.50686434
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.50582068
56	Metabolic pathways_Homo sapiens_hsa01100	0.41108259
57	Pertussis_Homo sapiens_hsa05133	0.38397219
58	Lysine degradation_Homo sapiens_hsa00310	0.37138473
59	Sulfur relay system_Homo sapiens_hsa04122	0.35023439
60	Sulfur metabolism_Homo sapiens_hsa00920	0.34762059
61	Insulin resistance_Homo sapiens_hsa04931	0.28806317
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25842330
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25727584
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24217334
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.23694031
66	Pentose phosphate pathway_Homo sapiens_hsa00030	0.19381727
67	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.19125271
68	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.11004069
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.07058706
70	Amoebiasis_Homo sapiens_hsa05146	0.06552710
71	AMPK signaling pathway_Homo sapiens_hsa04152	0.05781220
72	Mineral absorption_Homo sapiens_hsa04978	0.03089616
73	Fatty acid elongation_Homo sapiens_hsa00062	0.02433318
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.00036637
75	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.2932459
76	FoxO signaling pathway_Homo sapiens_hsa04068	-0.2819855
77	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.2743305
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.2531142
79	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.2474770
80	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2431794
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.2430458
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1872233
83	Circadian rhythm_Homo sapiens_hsa04710	-0.1817066
84	Steroid biosynthesis_Homo sapiens_hsa00100	-0.1755547
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.1643518
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.1553554
87	Nitrogen metabolism_Homo sapiens_hsa00910	-0.1501758
88	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1188219
89	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0941803
90	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0937085
91	Other glycan degradation_Homo sapiens_hsa00511	-0.0900162
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	-0.0731461
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	-0.0694318
94	African trypanosomiasis_Homo sapiens_hsa05143	-0.0677905
95	Galactose metabolism_Homo sapiens_hsa00052	-0.0611712
96	Glutathione metabolism_Homo sapiens_hsa00480	-0.0534380
97	Folate biosynthesis_Homo sapiens_hsa00790	-0.0384470
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	-0.0070306
99	Serotonergic synapse_Homo sapiens_hsa04726	-0.0029870
100	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0011751

C3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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