C3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)9.98949560
2epoxygenase P450 pathway (GO:0019373)9.88056636
3exogenous drug catabolic process (GO:0042738)9.68307542
4complement activation, alternative pathway (GO:0006957)9.31458410
5drug catabolic process (GO:0042737)9.20819548
6glyoxylate metabolic process (GO:0046487)8.32163697
7L-phenylalanine catabolic process (GO:0006559)8.18904877
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)8.18904877
9regulation of fibrinolysis (GO:0051917)8.17597337
10regulation of protein activation cascade (GO:2000257)8.06520567
11ethanol oxidation (GO:0006069)7.75538393
12regulation of complement activation (GO:0030449)7.70135731
13L-phenylalanine metabolic process (GO:0006558)7.43070427
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.43070427
15negative regulation of fibrinolysis (GO:0051918)7.29497367
16protein carboxylation (GO:0018214)6.60913245
17peptidyl-glutamic acid carboxylation (GO:0017187)6.60913245
18urea metabolic process (GO:0019627)6.55255100
19imidazole-containing compound metabolic process (GO:0052803)6.55246553
20drug metabolic process (GO:0017144)6.49070544
21fibrinolysis (GO:0042730)6.28658502
22ethanol metabolic process (GO:0006067)6.20659301
23oxidative demethylation (GO:0070989)6.15724748
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.12415817
25aromatic amino acid family catabolic process (GO:0009074)6.09866060
26serine family amino acid catabolic process (GO:0009071)6.04589322
27blood coagulation, intrinsic pathway (GO:0007597)6.00416337
28nitrogen cycle metabolic process (GO:0071941)5.96817062
29opsonization (GO:0008228)5.84302985
30regulation of triglyceride catabolic process (GO:0010896)5.68518800
31protein activation cascade (GO:0072376)5.68210399
32urea cycle (GO:0000050)5.60224057
33complement activation (GO:0006956)5.56775307
34bile acid biosynthetic process (GO:0006699)5.55926692
35regulation of plasminogen activation (GO:0010755)5.49797843
36negative regulation of cholesterol transport (GO:0032375)5.43206920
37negative regulation of sterol transport (GO:0032372)5.43206920
38complement activation, classical pathway (GO:0006958)5.40076861
39cellular glucuronidation (GO:0052695)5.29061367
40glycine metabolic process (GO:0006544)5.13584962
41phenylpropanoid metabolic process (GO:0009698)5.05002488
42glucuronate metabolic process (GO:0019585)5.02752224
43uronic acid metabolic process (GO:0006063)5.02752224
44tyrosine metabolic process (GO:0006570)5.01765550
45acute-phase response (GO:0006953)4.98181088
46bile acid metabolic process (GO:0008206)4.92793267
47regulation of humoral immune response (GO:0002920)4.91686170
48disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.83176489
49killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.83176489
50glutamate metabolic process (GO:0006536)4.82371246
51S-adenosylmethionine metabolic process (GO:0046500)4.82020856
52negative regulation of protein activation cascade (GO:2000258)4.76767381
53cytolysis (GO:0019835)4.76026913
54negative regulation of hemostasis (GO:1900047)4.68432328
55negative regulation of blood coagulation (GO:0030195)4.68432328
56positive regulation of triglyceride lipase activity (GO:0061365)4.65987706
57positive regulation of lipoprotein lipase activity (GO:0051006)4.65987706
58bile acid and bile salt transport (GO:0015721)4.60092213
59triglyceride homeostasis (GO:0070328)4.55661278
60acylglycerol homeostasis (GO:0055090)4.55661278
61protein-lipid complex remodeling (GO:0034368)4.37549002
62macromolecular complex remodeling (GO:0034367)4.37549002
63plasma lipoprotein particle remodeling (GO:0034369)4.37549002
64alkaloid metabolic process (GO:0009820)4.35438386
65alpha-amino acid catabolic process (GO:1901606)4.27045178
66negative regulation of coagulation (GO:0050819)4.24669659
67tryptophan catabolic process (GO:0006569)4.24053779
68indole-containing compound catabolic process (GO:0042436)4.24053779
69indolalkylamine catabolic process (GO:0046218)4.24053779
70negative regulation of wound healing (GO:0061045)4.21606711
71serine family amino acid metabolic process (GO:0009069)4.12035987
72positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.10986370
73cholesterol efflux (GO:0033344)4.08389936
74high-density lipoprotein particle remodeling (GO:0034375)4.07152935
75phospholipid efflux (GO:0033700)4.05451124
76positive regulation of blood coagulation (GO:0030194)4.03876775
77positive regulation of hemostasis (GO:1900048)4.03876775
78aromatic amino acid family metabolic process (GO:0009072)3.98727357
79cellular ketone body metabolic process (GO:0046950)3.96668226
80negative regulation of complement activation (GO:0045916)3.91139804
81reverse cholesterol transport (GO:0043691)3.77518151
82arginine metabolic process (GO:0006525)3.77320063
83amino-acid betaine metabolic process (GO:0006577)3.71440561
84positive regulation of coagulation (GO:0050820)3.69595096
85acute inflammatory response (GO:0002526)3.68529322
86flavonoid metabolic process (GO:0009812)3.68199726
87serine family amino acid biosynthetic process (GO:0009070)3.66486477
88negative regulation of lipase activity (GO:0060192)3.62593170
89cellular amino acid catabolic process (GO:0009063)3.62460917
90positive regulation of lipid catabolic process (GO:0050996)3.59963684
91tryptophan metabolic process (GO:0006568)3.57989537
92positive regulation of fatty acid biosynthetic process (GO:0045723)3.57888084
93regulation of cholesterol esterification (GO:0010872)3.50979088
94cysteine metabolic process (GO:0006534)3.50144546
95regulation of acute inflammatory response (GO:0002673)3.48733463
96ketone body metabolic process (GO:1902224)3.48088019
97xenobiotic metabolic process (GO:0006805)3.45335466
98aldehyde catabolic process (GO:0046185)3.44516434
99intestinal cholesterol absorption (GO:0030299)3.44436205
100response to mercury ion (GO:0046689)3.44188634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse7.06060334
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.05617133
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.87227948
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.71816972
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.71425082
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.94766156
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.77627807
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.23541940
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.81609874
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44564083
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.12906789
12HTT_18923047_ChIP-ChIP_STHdh_Human2.03501227
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4945723
14HNF4A_19822575_ChIP-Seq_HepG2_Human1.97233863
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.90399209
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84690998
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58543766
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47618234
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36950277
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.34445729
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33543682
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32164001
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19338249
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.15299453
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08492380
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.04608783
27PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04390084
28AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02319709
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98198440
30BCAT_22108803_ChIP-Seq_LS180_Human0.96216371
31RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91568058
32CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91460325
33IRF1_19129219_ChIP-ChIP_H3396_Human0.88258401
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87982844
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87811997
36HNFA_21074721_ChIP-Seq_CACO-2_Human0.86113695
37PHF8_20622853_ChIP-Seq_HELA_Human0.84297345
38CBP_21632823_ChIP-Seq_H3396_Human0.81575075
39AR_20517297_ChIP-Seq_VCAP_Human0.80554615
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80323806
41GATA1_22025678_ChIP-Seq_K562_Human0.76590112
42LXR_22292898_ChIP-Seq_THP-1_Human0.75503429
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74852872
44KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74838386
45NFYA_21822215_ChIP-Seq_K562_Human0.74306213
46GATA6_21074721_ChIP-Seq_CACO-2_Human0.74218848
47ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71262624
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70723573
49TP53_18474530_ChIP-ChIP_U2OS_Human0.69782192
50RAC3_21632823_ChIP-Seq_H3396_Human0.68484903
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67563802
52PIAS1_25552417_ChIP-Seq_VCAP_Human0.67479299
53CEBPB_22108803_ChIP-Seq_LS180_Human0.67076955
54NFE2_27457419_Chip-Seq_LIVER_Mouse0.66990346
55GATA4_25053715_ChIP-Seq_YYC3_Human0.66946446
56MYC_19829295_ChIP-Seq_ESCs_Human0.65370310
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.65195804
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64457790
59CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64060865
60* SOX2_21211035_ChIP-Seq_LN229_Human0.62989360
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62358128
62SPI1_20517297_ChIP-Seq_HL60_Human0.61186078
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61000033
64ETV1_20927104_ChIP-Seq_GIST48_Human0.60873522
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60683877
66FOXA1_25552417_ChIP-Seq_VCAP_Human0.58887760
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58634960
68TAF2_19829295_ChIP-Seq_ESCs_Human0.58194683
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57765285
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56639674
71P53_21459846_ChIP-Seq_SAOS-2_Human0.56400223
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.55879388
73SMC4_20622854_ChIP-Seq_HELA_Human0.55602815
74POU3F2_20337985_ChIP-ChIP_501MEL_Human0.55599648
75E2F1_20622854_ChIP-Seq_HELA_Human0.55418544
76DNAJC2_21179169_ChIP-ChIP_NT2_Human0.54943615
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.54851789
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.54616057
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54575490
80ERG_20517297_ChIP-Seq_VCAP_Human0.54487212
81CTCF_27219007_Chip-Seq_Bcells_Human0.54383201
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.53685345
83NFYB_21822215_ChIP-Seq_K562_Human0.53659734
84MYC_19915707_ChIP-ChIP_AK7_Human0.53530855
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.53311491
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.53100148
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53075512
88SA1_27219007_Chip-Seq_Bcells_Human0.52469482
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.52447791
90CTCF_20526341_ChIP-Seq_ESCs_Human0.51824599
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.49691614
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.48789319
93POU5F1_16518401_ChIP-PET_MESCs_Mouse0.47791507
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.47229873
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.46922582
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.46780707
97ER_23166858_ChIP-Seq_MCF-7_Human0.46018306
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.46013276
99RBPJ_21746931_ChIP-Seq_IB4_Human0.45422968
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.44789228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.65132397
2MP0008875_abnormal_xenobiotic_pharmacok6.36151902
3MP0005360_urolithiasis6.23287583
4MP0005085_abnormal_gallbladder_physiolo6.20728472
5MP0005365_abnormal_bile_salt5.33053742
6MP0003195_calcinosis5.30504493
7MP0002138_abnormal_hepatobiliary_system4.28447642
8MP0003252_abnormal_bile_duct4.05420580
9MP0001666_abnormal_nutrient_absorption3.06826488
10MP0010329_abnormal_lipoprotein_level2.95689186
11MP0003191_abnormal_cellular_cholesterol2.86579042
12MP0003868_abnormal_feces_composition2.75870490
13MP0009697_abnormal_copulation2.44820163
14MP0005332_abnormal_amino_acid2.41570423
15MP0010368_abnormal_lymphatic_system2.25744816
16MP0003806_abnormal_nucleotide_metabolis2.24690233
17MP0000609_abnormal_liver_physiology1.89413769
18MP0002876_abnormal_thyroid_physiology1.81992400
19MP0002118_abnormal_lipid_homeostasis1.72361401
20MP0009840_abnormal_foam_cell1.71001122
21MP0005670_abnormal_white_adipose1.58742846
22MP0001764_abnormal_homeostasis1.55439823
23MP0002132_abnormal_respiratory_system1.39646871
24MP0003656_abnormal_erythrocyte_physiolo1.30025443
25MP0009053_abnormal_anal_canal1.27632620
26MP0001661_extended_life_span1.26640769
27MP0009764_decreased_sensitivity_to1.20302797
28MP0004019_abnormal_vitamin_homeostasis1.17264840
29MP0005319_abnormal_enzyme/_coenzyme1.09513630
30MP0005408_hypopigmentation1.08175850
31MP0000598_abnormal_liver_morphology1.07935245
32MP0002282_abnormal_trachea_morphology1.07527819
33MP0009763_increased_sensitivity_to1.00916636
34MP0008872_abnormal_physiological_respon0.99074669
35MP0005584_abnormal_enzyme/coenzyme_acti0.98612227
36MP0009643_abnormal_urine_homeostasis0.94660557
37MP0002971_abnormal_brown_adipose0.92902123
38MP0005451_abnormal_body_composition0.90178005
39MP0009642_abnormal_blood_homeostasis0.86849873
40MP0008469_abnormal_protein_level0.83108455
41MP0005376_homeostasis/metabolism_phenot0.83082767
42MP0002249_abnormal_larynx_morphology0.82378018
43MP0000604_amyloidosis0.78959559
44MP0005535_abnormal_body_temperature0.77280991
45MP0001915_intracranial_hemorrhage0.77224843
46MP0003879_abnormal_hair_cell0.73191131
47MP0003186_abnormal_redox_activity0.72802798
48MP0005266_abnormal_metabolism0.72085251
49MP0005395_other_phenotype0.71823941
50MP0003690_abnormal_glial_cell0.70650774
51MP0005636_abnormal_mineral_homeostasis0.70064823
52MP0009785_altered_susceptibility_to0.68958347
53MP0002168_other_aberrant_phenotype0.68631294
54MP0005187_abnormal_penis_morphology0.66653794
55MP0008874_decreased_physiological_sensi0.65175377
56MP0004130_abnormal_muscle_cell0.65120715
57MP0005334_abnormal_fat_pad0.63452557
58MP0009765_abnormal_xenobiotic_induced0.63122607
59MP0002078_abnormal_glucose_homeostasis0.61549394
60MP0004782_abnormal_surfactant_physiolog0.61082008
61MP0005464_abnormal_platelet_physiology0.59906292
62MP0005166_decreased_susceptibility_to0.58323262
63MP0003011_delayed_dark_adaptation0.56423805
64MP0003075_altered_response_to0.52751514
65MP0002332_abnormal_exercise_endurance0.52725908
66MP0005023_abnormal_wound_healing0.49994864
67MP0003638_abnormal_response/metabolism_0.48092342
68MP0000467_abnormal_esophagus_morphology0.42942068
69MP0006292_abnormal_olfactory_placode0.41428541
70MP0000249_abnormal_blood_vessel0.41057446
71MP0003705_abnormal_hypodermis_morpholog0.37333285
72MP0005448_abnormal_energy_balance0.37135160
73MP0006036_abnormal_mitochondrial_physio0.36403534
74MP0001986_abnormal_taste_sensitivity0.34735964
75MP0001545_abnormal_hematopoietic_system0.33455885
76MP0005397_hematopoietic_system_phenotyp0.33455885
77MP0004883_abnormal_blood_vessel0.32554214
78MP0002136_abnormal_kidney_physiology0.32006252
79MP0005164_abnormal_response_to0.30786626
80MP0009115_abnormal_fat_cell0.30166495
81MP0000566_synostosis0.29871829
82MP0003953_abnormal_hormone_level0.29383954
83MP0000639_abnormal_adrenal_gland0.29383778
84MP0001845_abnormal_inflammatory_respons0.24968521
85MP0003436_decreased_susceptibility_to0.23854054
86MP0005647_abnormal_sex_gland0.23312011
87MP0005666_abnormal_adipose_tissue0.23193848
88MP0001851_eye_inflammation0.22384595
89MP0005220_abnormal_exocrine_pancreas0.20643535
90MP0002128_abnormal_blood_circulation0.19743196
91MP0005058_abnormal_lysosome_morphology0.19696643
92MP0002970_abnormal_white_adipose0.19031218
93MP0001881_abnormal_mammary_gland0.18968631
94MP0008873_increased_physiological_sensi0.18545917
95MP0003718_maternal_effect0.18235730
96MP0010155_abnormal_intestine_physiology0.18074345
97MP0005083_abnormal_biliary_tract0.17410073
98MP0002295_abnormal_pulmonary_circulatio0.16239890
99MP0003878_abnormal_ear_physiology0.16213888
100MP0005377_hearing/vestibular/ear_phenot0.16213888

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.49132479
2Prolonged partial thromboplastin time (HP:0003645)9.36170645
3Abnormality of aromatic amino acid family metabolism (HP:0004338)9.04780177
4Abnormality of complement system (HP:0005339)8.72051006
5Hypobetalipoproteinemia (HP:0003563)7.47274032
6Conjugated hyperbilirubinemia (HP:0002908)6.72243302
7Systemic lupus erythematosus (HP:0002725)6.72185339
8Joint hemorrhage (HP:0005261)6.59523357
9Hyperlipoproteinemia (HP:0010980)6.33675753
10Glomerulonephritis (HP:0000099)5.44706177
11Recurrent gram-negative bacterial infections (HP:0005420)5.38148741
12Xanthomatosis (HP:0000991)4.99567922
13Intrahepatic cholestasis (HP:0001406)4.94207404
14Abnormality of pyrimidine metabolism (HP:0004353)4.87673192
15Abnormality of the intrinsic pathway (HP:0010989)4.50933490
16Spontaneous abortion (HP:0005268)4.48053269
17Hypolipoproteinemia (HP:0010981)4.42113050
18Abnormality of the common coagulation pathway (HP:0010990)4.30438421
19Nephritis (HP:0000123)4.03811256
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.90612237
21Hypoalphalipoproteinemia (HP:0003233)3.84901704
22Abnormality of methionine metabolism (HP:0010901)3.72169390
23Neonatal hypoglycemia (HP:0001998)3.37501592
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.24930886
25Hyperglycinemia (HP:0002154)3.22610982
26Delayed CNS myelination (HP:0002188)3.16262613
27Fair hair (HP:0002286)3.10794623
28Hyperammonemia (HP:0001987)2.99186630
29Gingival bleeding (HP:0000225)2.96112735
30Fat malabsorption (HP:0002630)2.81204776
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.81137953
32Abnormality of glycine metabolism (HP:0010895)2.79432721
33Abnormality of serine family amino acid metabolism (HP:0010894)2.79432721
34Hypercholesterolemia (HP:0003124)2.78921982
35Thrombophlebitis (HP:0004418)2.73032031
36Generalized aminoaciduria (HP:0002909)2.67557730
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.66621762
38Abnormality of nucleobase metabolism (HP:0010932)2.64478821
39Mitral stenosis (HP:0001718)2.60770075
40Epidermoid cyst (HP:0200040)2.60747302
41Hemorrhage of the eye (HP:0011885)2.58734725
42Hyperbilirubinemia (HP:0002904)2.55397798
43Purpura (HP:0000979)2.48531734
44Abnormality of serum amino acid levels (HP:0003112)2.47122513
45Osteomalacia (HP:0002749)2.45304999
46Hepatocellular carcinoma (HP:0001402)2.40470192
47Vascular calcification (HP:0004934)2.39414390
48Pulmonary embolism (HP:0002204)2.36428197
49Menorrhagia (HP:0000132)2.34383735
50Rickets (HP:0002748)2.23224999
51Hyperglycinuria (HP:0003108)2.21550862
52Generalized hypopigmentation of hair (HP:0011358)2.21438668
53Ketosis (HP:0001946)2.14516089
54Cholelithiasis (HP:0001081)2.13148450
55Cardiovascular calcification (HP:0011915)2.11907744
56Steatorrhea (HP:0002570)2.11820275
57Metabolic acidosis (HP:0001942)2.06585437
58Cholecystitis (HP:0001082)2.04145835
59Abnormal gallbladder physiology (HP:0012438)2.04145835
60Complement deficiency (HP:0004431)10.8304848
61Abnormality of monocarboxylic acid metabolism (HP:0010996)10.3046717
62Abnormal gallbladder morphology (HP:0012437)1.97622295
63Abnormality of iron homeostasis (HP:0011031)1.97183089
64Blue irides (HP:0000635)1.95608151
65Increased serum ferritin (HP:0003281)1.89625728
66Elevated alkaline phosphatase (HP:0003155)1.88872592
67Reduced antithrombin III activity (HP:0001976)1.88767313
68Myocardial infarction (HP:0001658)1.87391067
69Joint swelling (HP:0001386)1.87012087
70Hyperphosphaturia (HP:0003109)1.84304278
71Epistaxis (HP:0000421)1.82076304
72Arthropathy (HP:0003040)1.80746643
73Gangrene (HP:0100758)1.79996570
74Increased mean platelet volume (HP:0011877)1.79627663
75Abnormal enzyme/coenzyme activity (HP:0012379)1.76410172
76Abnormality of transition element cation homeostasis (HP:0011030)1.76272232
77Abnormality of alkaline phosphatase activity (HP:0004379)1.72458906
78Cerebral palsy (HP:0100021)1.72293945
79Irritability (HP:0000737)1.71517180
80Atrioventricular block (HP:0001678)1.70711272
81Hypochromic microcytic anemia (HP:0004840)1.66191008
82Abnormality of vitamin metabolism (HP:0100508)1.66085279
83Gout (HP:0001997)1.64490390
84Abnormal platelet volume (HP:0011876)1.63471169
85Abnormality of purine metabolism (HP:0004352)1.62181401
86Reticulocytosis (HP:0001923)1.60396200
87Abnormality of the Achilles tendon (HP:0005109)1.60216569
88Skin nodule (HP:0200036)1.59535232
89Hypophosphatemic rickets (HP:0004912)1.57281904
90Pancreatitis (HP:0001733)1.56054136
91Glycosuria (HP:0003076)1.55366120
92Abnormality of urine glucose concentration (HP:0011016)1.55366120
93Poikilocytosis (HP:0004447)1.55123751
94Impaired platelet aggregation (HP:0003540)1.54731996
95Abnormal platelet function (HP:0011869)1.54731996
96Enlarged kidneys (HP:0000105)1.52945270
97Bifid scrotum (HP:0000048)1.50543542
98Lethargy (HP:0001254)1.49855689
99Bile duct proliferation (HP:0001408)1.48939051
100Abnormal biliary tract physiology (HP:0012439)1.48939051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.46178641
2FGFR43.98018737
3SIK13.58724522
4TRIB33.56804259
5PIK3CG3.53070678
6BCKDK3.13878958
7TYK22.86733455
8RIPK12.39382021
9PIK3CA2.31027266
10PRKACG2.27076804
11NTRK32.16254126
12EPHA32.02197170
13PRKAA21.96288766
14TAOK31.87957173
15MAP2K41.76616639
16PRPF4B1.75734440
17TNK21.62879134
18MAPK111.61353552
19JAK11.48964513
20KDR1.48931322
21MAP3K31.47328463
22PRKCG1.38499151
23IGF1R1.34405613
24FGFR31.32455901
25TIE11.27357324
26ERBB21.24602097
27PDPK11.23269874
28BLK1.17196448
29NLK1.16718193
30CSF1R1.12604846
31NEK91.08000544
32ABL21.07184527
33JAK21.06203270
34EPHB11.03462850
35MAP3K131.00413813
36TBK10.99964646
37PRKG10.99217398
38FER0.97346695
39PRKCZ0.96932798
40PKN20.96396598
41CAMKK20.94625127
42MAPK70.93841014
43MAPK120.92567080
44PRKACA0.91755746
45PDK20.91615718
46DAPK20.88443491
47FRK0.86532336
48PDK10.85996172
49MST1R0.85848911
50MAP3K10.81697202
51EPHA40.80571752
52PRKAA10.80487183
53INSRR0.73333041
54AKT30.73251203
55MAP3K110.72380012
56MAPK40.71165822
57TAOK20.70497336
58CAMKK10.70492346
59KIT0.66178222
60RET0.64096465
61DYRK1B0.61124743
62IKBKE0.61062217
63TGFBR20.60664403
64MYLK0.59729887
65RPS6KA30.57325778
66PRKCA0.56414916
67PRKACB0.55204343
68CDK60.55143107
69PRKCB0.54686239
70CSNK1D0.52651270
71PINK10.50944916
72ARAF0.50430834
73ZAP700.49307470
74MAP4K10.46636951
75SRC0.46507083
76SGK2230.45980099
77SGK4940.45980099
78SGK10.43481006
79CSNK1E0.43321888
80MAP3K60.42261647
81MET0.42084137
82SGK20.41984995
83GSK3A0.40235783
84CSNK2A10.39051996
85SGK30.38618454
86MAPK30.37977168
87CAMK2G0.37755916
88MAPKAPK50.37051329
89DYRK1A0.36434287
90WNK30.34864308
91MAP3K20.34784709
92ICK0.33944375
93MAP3K70.32214320
94TXK0.31129959
95CSNK2A20.30319053
96CDK40.29938053
97MTOR0.29778998
98GRK10.29742243
99CSNK1A10.28184003
100MAP2K20.27848359

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.63681034
2Caffeine metabolism_Homo sapiens_hsa002324.59346574
3Complement and coagulation cascades_Homo sapiens_hsa046104.10369301
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.63653773
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.46540719
6Retinol metabolism_Homo sapiens_hsa008303.41598063
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08897819
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.91848470
9Chemical carcinogenesis_Homo sapiens_hsa052042.86848495
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.84655490
11Fatty acid degradation_Homo sapiens_hsa000712.66909238
12Arginine biosynthesis_Homo sapiens_hsa002202.64270344
13Tyrosine metabolism_Homo sapiens_hsa003502.63147459
14Phenylalanine metabolism_Homo sapiens_hsa003602.59647100
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.37819949
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34924711
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.29713462
18Histidine metabolism_Homo sapiens_hsa003402.22296356
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13328149
20Linoleic acid metabolism_Homo sapiens_hsa005911.96941593
21Butanoate metabolism_Homo sapiens_hsa006501.84845802
22Tryptophan metabolism_Homo sapiens_hsa003801.80375646
23Bile secretion_Homo sapiens_hsa049761.60553167
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59990546
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58851856
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55712482
27Prion diseases_Homo sapiens_hsa050201.54245781
28Staphylococcus aureus infection_Homo sapiens_hsa051501.49394977
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39966573
30Starch and sucrose metabolism_Homo sapiens_hsa005001.39031600
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.38167811
32PPAR signaling pathway_Homo sapiens_hsa033201.31409608
33Arachidonic acid metabolism_Homo sapiens_hsa005901.23284465
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.22705273
35beta-Alanine metabolism_Homo sapiens_hsa004101.20157716
36Biosynthesis of amino acids_Homo sapiens_hsa012301.19393558
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18336506
38Peroxisome_Homo sapiens_hsa041461.14616641
39Vitamin B6 metabolism_Homo sapiens_hsa007501.09810199
40Pyruvate metabolism_Homo sapiens_hsa006201.04678463
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01602040
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99584887
43One carbon pool by folate_Homo sapiens_hsa006700.95513361
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93727403
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89751948
46Arginine and proline metabolism_Homo sapiens_hsa003300.88599676
47Carbon metabolism_Homo sapiens_hsa012000.82266923
48ABC transporters_Homo sapiens_hsa020100.76685168
49Propanoate metabolism_Homo sapiens_hsa006400.71845178
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67748667
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67423947
52Fat digestion and absorption_Homo sapiens_hsa049750.66823118
53Fatty acid metabolism_Homo sapiens_hsa012120.54879428
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50686434
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.50582068
56Metabolic pathways_Homo sapiens_hsa011000.41108259
57Pertussis_Homo sapiens_hsa051330.38397219
58Lysine degradation_Homo sapiens_hsa003100.37138473
59Sulfur relay system_Homo sapiens_hsa041220.35023439
60Sulfur metabolism_Homo sapiens_hsa009200.34762059
61Insulin resistance_Homo sapiens_hsa049310.28806317
62Glycerolipid metabolism_Homo sapiens_hsa005610.25842330
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25727584
64Systemic lupus erythematosus_Homo sapiens_hsa053220.24217334
65Glucagon signaling pathway_Homo sapiens_hsa049220.23694031
66Pentose phosphate pathway_Homo sapiens_hsa000300.19381727
67Fructose and mannose metabolism_Homo sapiens_hsa000510.19125271
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.11004069
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07058706
70Amoebiasis_Homo sapiens_hsa051460.06552710
71AMPK signaling pathway_Homo sapiens_hsa041520.05781220
72Mineral absorption_Homo sapiens_hsa049780.03089616
73Fatty acid elongation_Homo sapiens_hsa000620.02433318
74Selenocompound metabolism_Homo sapiens_hsa004500.00036637
75Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2932459
76FoxO signaling pathway_Homo sapiens_hsa04068-0.2819855
77Sphingolipid metabolism_Homo sapiens_hsa00600-0.2743305
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2531142
79Type II diabetes mellitus_Homo sapiens_hsa04930-0.2474770
80Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2431794
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2430458
82Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1872233
83Circadian rhythm_Homo sapiens_hsa04710-0.1817066
84Steroid biosynthesis_Homo sapiens_hsa00100-0.1755547
85Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1643518
86Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1553554
87Nitrogen metabolism_Homo sapiens_hsa00910-0.1501758
88Insulin signaling pathway_Homo sapiens_hsa04910-0.1188219
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0941803
90Renin-angiotensin system_Homo sapiens_hsa04614-0.0937085
91Other glycan degradation_Homo sapiens_hsa00511-0.0900162
92Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0731461
93Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0694318
94African trypanosomiasis_Homo sapiens_hsa05143-0.0677905
95Galactose metabolism_Homo sapiens_hsa00052-0.0611712
96Glutathione metabolism_Homo sapiens_hsa00480-0.0534380
97Folate biosynthesis_Homo sapiens_hsa00790-0.0384470
98Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0070306
99Serotonergic synapse_Homo sapiens_hsa04726-0.0029870
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0011751

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