ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* regulation of protein activation cascade (GO:2000257)	8.27847421
2	complement activation, alternative pathway (GO:0006957)	8.22203091
3	* regulation of complement activation (GO:0030449)	8.03057058
4	negative regulation of fibrinolysis (GO:0051918)	7.85143424
5	regulation of fibrinolysis (GO:0051917)	7.56440250
6	protein carboxylation (GO:0018214)	6.77454933
7	peptidyl-glutamic acid carboxylation (GO:0017187)	6.77454933
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.29255238
9	L-phenylalanine catabolic process (GO:0006559)	6.29255238
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.89410469
11	L-phenylalanine metabolic process (GO:0006558)	5.89410469
12	blood coagulation, intrinsic pathway (GO:0007597)	5.82128382
13	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.70431509
14	epoxygenase P450 pathway (GO:0019373)	5.57426545
15	exogenous drug catabolic process (GO:0042738)	5.47504599
16	regulation of cholesterol esterification (GO:0010872)	5.38628757
17	negative regulation of sterol transport (GO:0032372)	5.37023033
18	negative regulation of cholesterol transport (GO:0032375)	5.37023033
19	fibrinolysis (GO:0042730)	5.36586032
20	* protein activation cascade (GO:0072376)	5.29415456
21	protein-lipid complex remodeling (GO:0034368)	5.29267602
22	macromolecular complex remodeling (GO:0034367)	5.29267602
23	plasma lipoprotein particle remodeling (GO:0034369)	5.29267602
24	regulation of plasminogen activation (GO:0010755)	5.28431931
25	very-low-density lipoprotein particle assembly (GO:0034379)	5.26291728
26	* regulation of apoptotic cell clearance (GO:2000425)	5.24772297
27	drug catabolic process (GO:0042737)	5.23387867
28	* complement activation, classical pathway (GO:0006958)	5.22854679
29	negative regulation of protein activation cascade (GO:2000258)	5.21507401
30	ethanol oxidation (GO:0006069)	5.17620335
31	omega-hydroxylase P450 pathway (GO:0097267)	5.09252179
32	cholesterol efflux (GO:0033344)	5.08169270
33	* complement activation (GO:0006956)	4.97037030
34	plasma lipoprotein particle assembly (GO:0034377)	4.92106297
35	high-density lipoprotein particle remodeling (GO:0034375)	4.90362344
36	glyoxylate metabolic process (GO:0046487)	4.88749869
37	intestinal cholesterol absorption (GO:0030299)	4.85783465
38	low-density lipoprotein particle remodeling (GO:0034374)	4.81733832
39	acute-phase response (GO:0006953)	4.80645672
40	* regulation of humoral immune response (GO:0002920)	4.79259562
41	phospholipid efflux (GO:0033700)	4.78122970
42	urea metabolic process (GO:0019627)	4.72404836
43	reverse cholesterol transport (GO:0043691)	4.62494947
44	opsonization (GO:0008228)	4.61223226
45	plasma lipoprotein particle organization (GO:0071827)	4.45905652
46	protein-lipid complex assembly (GO:0065005)	4.44648104
47	negative regulation of hemostasis (GO:1900047)	4.41530682
48	negative regulation of blood coagulation (GO:0030195)	4.41530682
49	plasma lipoprotein particle clearance (GO:0034381)	4.38528500
50	positive regulation of lipoprotein lipase activity (GO:0051006)	4.37180481
51	positive regulation of triglyceride lipase activity (GO:0061365)	4.37180481
52	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.28267806
53	nitrogen cycle metabolic process (GO:0071941)	4.27631438
54	negative regulation of complement activation (GO:0045916)	4.26964032
55	ethanol metabolic process (GO:0006067)	4.23411628
56	protein-lipid complex subunit organization (GO:0071825)	4.22819404
57	urea cycle (GO:0000050)	4.21529389
58	aromatic amino acid family catabolic process (GO:0009074)	4.19819142
59	positive regulation of blood coagulation (GO:0030194)	4.09723401
60	positive regulation of hemostasis (GO:1900048)	4.09723401
61	cellular glucuronidation (GO:0052695)	4.02810334
62	negative regulation of coagulation (GO:0050819)	4.02162504
63	triglyceride homeostasis (GO:0070328)	4.02089434
64	acylglycerol homeostasis (GO:0055090)	4.02089434
65	glutamate metabolic process (GO:0006536)	3.96423087
66	negative regulation of wound healing (GO:0061045)	3.93209527
67	negative regulation of lipase activity (GO:0060192)	3.88321565
68	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.85841582
69	serine family amino acid catabolic process (GO:0009071)	3.84645517
70	imidazole-containing compound metabolic process (GO:0052803)	3.80115979
71	regulation of triglyceride catabolic process (GO:0010896)	3.79288610
72	regulation of cholesterol biosynthetic process (GO:0045540)	3.79229329
73	cytolysis (GO:0019835)	3.78448643
74	bile acid metabolic process (GO:0008206)	3.78257616
75	uronic acid metabolic process (GO:0006063)	3.76988340
76	glucuronate metabolic process (GO:0019585)	3.76988340
77	bile acid biosynthetic process (GO:0006699)	3.75527357
78	positive regulation of coagulation (GO:0050820)	3.75510895
79	drug metabolic process (GO:0017144)	3.75028370
80	lipoprotein metabolic process (GO:0042157)	3.62479815
81	acute inflammatory response (GO:0002526)	3.51649866
82	regulation of cholesterol homeostasis (GO:2000188)	3.44068184
83	response to mercury ion (GO:0046689)	3.37175204
84	negative regulation of humoral immune response (GO:0002921)	3.35555755
85	cholesterol transport (GO:0030301)	3.34760708
86	sterol transport (GO:0015918)	3.34760708
87	positive regulation of steroid metabolic process (GO:0045940)	3.33968977
88	regulation of cholesterol metabolic process (GO:0090181)	3.33717881
89	cholesterol homeostasis (GO:0042632)	3.32456874
90	tyrosine metabolic process (GO:0006570)	3.32259444
91	regulation of bile acid biosynthetic process (GO:0070857)	3.31947092
92	phospholipid homeostasis (GO:0055091)	3.29416009
93	positive regulation of extracellular matrix organization (GO:1903055)	3.28486257
94	negative regulation of lipid transport (GO:0032369)	3.27565579
95	sterol homeostasis (GO:0055092)	3.27240565
96	* regulation of acute inflammatory response (GO:0002673)	3.24404495
97	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.23715385
98	proline metabolic process (GO:0006560)	3.19582999
99	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.18379368
100	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.18379368

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	9.29280672
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.70211302
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.80333938
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.74738953
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.34429879
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.24453566
7	* EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.17824178
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.67590402
9	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.16499834
10	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.05253455
11	FOXA2_19822575_ChIP-Seq_HepG2_Human	3.03353296
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.47952558
13	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.22961706
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.18280608
15	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.18172937
16	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.07202215
17	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.97249987
18	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.83556233
19	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.82446071
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.80586044
21	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.67092931
22	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.59604412
23	LXR_22292898_ChIP-Seq_THP-1_Human	1.56465490
24	* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.53510659
25	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.42170928
26	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.40364167
27	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.40155014
28	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.33628325
29	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.31471854
30	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.29785637
31	ZNF263_19887448_ChIP-Seq_K562_Human	1.23541966
32	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.22828081
33	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.22782437
34	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.21436410
35	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.20410497
36	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.20325596
37	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.16319945
38	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.14927842
39	GATA4_25053715_ChIP-Seq_YYC3_Human	1.12239335
40	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.11036462
41	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.10929463
42	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.10284146
43	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.06862163
44	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.03378779
45	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.03016312
46	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.02382677
47	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.01353732
48	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.00810471
49	DROSHA_22980978_ChIP-Seq_HELA_Human	0.96834439
50	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.96410933
51	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.95663136
52	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.95614483
53	SMC4_20622854_ChIP-Seq_HELA_Human	0.93248949
54	GATA6_25053715_ChIP-Seq_YYC3_Human	0.90579039
55	RACK7_27058665_Chip-Seq_MCF-7_Human	0.89735564
56	SOX2_20726797_ChIP-Seq_SW620_Human	0.88950285
57	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.88817210
58	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.88576914
59	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.88556899
60	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.88156174
61	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.87456249
62	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.86964575
63	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.86163460
64	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85804055
65	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.85357030
66	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85042407
67	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.84493285
68	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.83918467
69	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.83586699
70	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.81191791
71	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.81191791
72	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.80228515
73	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.76661225
74	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.76651412
75	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.75899925
76	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.75673963
77	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.75393322
78	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.75334831
79	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.75194814
80	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.75188816
81	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.74937487
82	KDM2B_26808549_Chip-Seq_K562_Human	0.74876092
83	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.74872098
84	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.74580282
85	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.69784153
86	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.67957280
87	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.67490148
88	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.67384987
89	CTCF_27219007_Chip-Seq_Bcells_Human	0.66541061
90	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.66492947
91	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.66398269
92	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.63927603
93	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.61675934
94	MYC_19915707_ChIP-ChIP_AK7_Human	0.61579226
95	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.59771934
96	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.59543671
97	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.58346657
98	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.57466074
99	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.56595722
100	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.56215399

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.05322737
2	MP0005360_urolithiasis	5.92501760
3	MP0005365_abnormal_bile_salt	5.59128881
4	MP0005085_abnormal_gallbladder_physiolo	5.01759436
5	MP0003195_calcinosis	5.01074887
6	MP0008875_abnormal_xenobiotic_pharmacok	4.42243873
7	MP0001666_abnormal_nutrient_absorption	3.61420480
8	MP0010329_abnormal_lipoprotein_level	3.49106421
9	MP0003252_abnormal_bile_duct	3.32977735
10	MP0009840_abnormal_foam_cell	2.79474119
11	MP0003868_abnormal_feces_composition	2.76486604
12	MP0002138_abnormal_hepatobiliary_system	2.73886837
13	MP0010368_abnormal_lymphatic_system	2.41166448
14	MP0003191_abnormal_cellular_cholesterol	2.36826669
15	MP0005332_abnormal_amino_acid	2.14800950
16	MP0000609_abnormal_liver_physiology	1.93834411
17	MP0002118_abnormal_lipid_homeostasis	1.88916360
18	MP0003122_maternal_imprinting	1.81721990
19	MP0005670_abnormal_white_adipose	1.75663312
20	MP0005058_abnormal_lysosome_morphology	1.61114324
21	MP0000566_synostosis	1.59997669
22	MP0003690_abnormal_glial_cell	1.47823056
23	MP0001915_intracranial_hemorrhage	1.47276824
24	MP0001661_extended_life_span	1.45545605
25	MP0000604_amyloidosis	1.43878775
26	MP0004019_abnormal_vitamin_homeostasis	1.43254076
27	MP0002876_abnormal_thyroid_physiology	1.38822453
28	MP0005451_abnormal_body_composition	1.37454089
29	MP0005408_hypopigmentation	1.33808671
30	MP0003879_abnormal_hair_cell	1.21763887
31	MP0002971_abnormal_brown_adipose	1.20890809
32	MP0002132_abnormal_respiratory_system	1.19210545
33	MP0005409_darkened_coat_color	1.14012867
34	MP0002089_abnormal_postnatal_growth/wei	1.13529526
35	MP0003329_amyloid_beta_deposits	1.13059851
36	MP0009780_abnormal_chondrocyte_physiolo	1.09851908
37	MP0005167_abnormal_blood-brain_barrier	1.08567265
38	MP0000598_abnormal_liver_morphology	1.06317484
39	MP0009643_abnormal_urine_homeostasis	1.06160215
40	MP0003172_abnormal_lysosome_physiology	1.06116216
41	MP0004272_abnormal_basement_membrane	1.04138554
42	MP0002909_abnormal_adrenal_gland	1.02930760
43	MP0005319_abnormal_enzyme/_coenzyme	1.02553692
44	MP0000639_abnormal_adrenal_gland	1.00906500
45	MP0001764_abnormal_homeostasis	0.99358216
46	MP0005636_abnormal_mineral_homeostasis	0.95761022
47	MP0005023_abnormal_wound_healing	0.95690425
48	MP0005584_abnormal_enzyme/coenzyme_acti	0.92350659
49	MP0009697_abnormal_copulation	0.90719458
50	MP0008438_abnormal_cutaneous_collagen	0.89005936
51	MP0003011_delayed_dark_adaptation	0.88496824
52	MP0009642_abnormal_blood_homeostasis	0.87458946
53	MP0000920_abnormal_myelination	0.86519489
54	MP0000678_abnormal_parathyroid_gland	0.83961704
55	MP0003566_abnormal_cell_adhesion	0.80862615
56	MP0003656_abnormal_erythrocyte_physiolo	0.79044640
57	MP0002249_abnormal_larynx_morphology	0.78502817
58	MP0002933_joint_inflammation	0.76295226
59	MP0003075_altered_response_to	0.74193422
60	MP0005164_abnormal_response_to	0.72698529
61	MP0002168_other_aberrant_phenotype	0.72630227
62	MP0000249_abnormal_blood_vessel	0.71802871
63	MP0002078_abnormal_glucose_homeostasis	0.71516973
64	MP0005464_abnormal_platelet_physiology	0.70630706
65	MP0009115_abnormal_fat_cell	0.68440700
66	MP0009763_increased_sensitivity_to	0.67040225
67	MP0008469_abnormal_protein_level	0.65801944
68	MP0004883_abnormal_blood_vessel	0.65452456
69	MP0003806_abnormal_nucleotide_metabolis	0.64950868
70	MP0005257_abnormal_intraocular_pressure	0.64836513
71	MP0005448_abnormal_energy_balance	0.64009760
72	MP0003705_abnormal_hypodermis_morpholog	0.63836102
73	MP0003183_abnormal_peptide_metabolism	0.63226771
74	MP0003123_paternal_imprinting	0.62959987
75	MP0003632_abnormal_nervous_system	0.62530946
76	MP0001756_abnormal_urination	0.60341207
77	MP0002282_abnormal_trachea_morphology	0.58300455
78	MP0005334_abnormal_fat_pad	0.56743401
79	MP0004264_abnormal_extraembryonic_tissu	0.55901901
80	MP0005666_abnormal_adipose_tissue	0.55741051
81	MP0005376_homeostasis/metabolism_phenot	0.55273902
82	MP0000003_abnormal_adipose_tissue	0.53907384
83	MP0005076_abnormal_cell_differentiation	0.51370520
84	MP0005395_other_phenotype	0.50399017
85	MP0003953_abnormal_hormone_level	0.50263337
86	MP0004782_abnormal_surfactant_physiolog	0.49029675
87	MP0003633_abnormal_nervous_system	0.48918584
88	MP0005166_decreased_susceptibility_to	0.47739056
89	MP0005375_adipose_tissue_phenotype	0.47335884
90	MP0005377_hearing/vestibular/ear_phenot	0.46838046
91	MP0003878_abnormal_ear_physiology	0.46838046
92	MP0002896_abnormal_bone_mineralization	0.46646304
93	MP0002136_abnormal_kidney_physiology	0.46266508
94	MP0003638_abnormal_response/metabolism_	0.44667278
95	MP0009384_cardiac_valve_regurgitation	0.44207516
96	MP0003631_nervous_system_phenotype	0.43667474
97	MP0003300_gastrointestinal_ulcer	0.42642922
98	MP0002970_abnormal_white_adipose	0.42481951
99	MP0005220_abnormal_exocrine_pancreas	0.41855274
100	MP0003950_abnormal_plasma_membrane	0.41028725

Predicted human phenotypes

Rank	Gene Set	Z-score
1	* Complement deficiency (HP:0004431)	9.44468021
2	Prolonged partial thromboplastin time (HP:0003645)	8.00008942
3	* Abnormality of complement system (HP:0005339)	7.49061733
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	7.08393151
5	Joint hemorrhage (HP:0005261)	6.69424197
6	Hypobetalipoproteinemia (HP:0003563)	6.54389722
7	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.25361711
8	* Systemic lupus erythematosus (HP:0002725)	5.66576632
9	* Glomerulonephritis (HP:0000099)	5.50147333
10	Xanthomatosis (HP:0000991)	5.32095457
11	Abnormality of the common coagulation pathway (HP:0010990)	5.24311740
12	Conjugated hyperbilirubinemia (HP:0002908)	4.89527101
13	Spontaneous abortion (HP:0005268)	4.52719320
14	Hypolipoproteinemia (HP:0010981)	4.18915091
15	Hyperlipoproteinemia (HP:0010980)	4.13953389
16	Intrahepatic cholestasis (HP:0001406)	4.05639059
17	Recurrent gram-negative bacterial infections (HP:0005420)	3.98193497
18	Hypercholesterolemia (HP:0003124)	3.88644121
19	Hemorrhage of the eye (HP:0011885)	3.85146803
20	* Nephritis (HP:0000123)	3.74560734
21	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.44131895
22	Menorrhagia (HP:0000132)	3.34856391
23	Mitral stenosis (HP:0001718)	3.32271572
24	Abnormality of the intrinsic pathway (HP:0010989)	3.31242499
25	Hypoalphalipoproteinemia (HP:0003233)	3.26230660
26	Gingival bleeding (HP:0000225)	3.24722973
27	Fat malabsorption (HP:0002630)	3.06976276
28	Vascular calcification (HP:0004934)	3.05779603
29	Epidermoid cyst (HP:0200040)	3.02625268
30	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.80422385
31	Cardiovascular calcification (HP:0011915)	2.73945436
32	Abnormality of pyrimidine metabolism (HP:0004353)	2.64760132
33	Myocardial infarction (HP:0001658)	2.63488638
34	Hepatocellular carcinoma (HP:0001402)	2.47822869
35	Rickets (HP:0002748)	2.46980070
36	Skin nodule (HP:0200036)	2.37886103
37	* Thrombophlebitis (HP:0004418)	2.26084636
38	Acanthocytosis (HP:0001927)	2.21962605
39	Abnormality of carpal bone ossification (HP:0006257)	2.18627211
40	* Purpura (HP:0000979)	2.16815374
41	Osteomalacia (HP:0002749)	2.15048336
42	Facial shape deformation (HP:0011334)	2.11310064
43	Potter facies (HP:0002009)	2.11310064
44	Amyloidosis (HP:0011034)	2.07633424
45	Hyperammonemia (HP:0001987)	2.06983249
46	Hypophosphatemic rickets (HP:0004912)	2.06210037
47	Abnormal tarsal ossification (HP:0008369)	2.01788179
48	Steatorrhea (HP:0002570)	2.00414685
49	Deep venous thrombosis (HP:0002625)	10.3230278
50	Hydroxyprolinuria (HP:0003080)	1.99429380
51	Abnormality of proline metabolism (HP:0010907)	1.99429380
52	Arthropathy (HP:0003040)	1.98562874
53	Protrusio acetabuli (HP:0003179)	1.97453204
54	Abnormality of serine family amino acid metabolism (HP:0010894)	1.97058199
55	Abnormality of glycine metabolism (HP:0010895)	1.97058199
56	Abnormality of methionine metabolism (HP:0010901)	1.96096137
57	Hyperglycinemia (HP:0002154)	1.90475583
58	Delayed CNS myelination (HP:0002188)	1.89184838
59	Abnormal delivery (HP:0001787)	1.88898012
60	Abnormality of the Achilles tendon (HP:0005109)	1.88211536
61	Flat acetabular roof (HP:0003180)	1.86497774
62	Joint swelling (HP:0001386)	1.86096425
63	Epistaxis (HP:0000421)	1.83928947
64	Hyperglycinuria (HP:0003108)	1.83381459
65	Bifid scrotum (HP:0000048)	1.81965807
66	Abnormality of nucleobase metabolism (HP:0010932)	1.81165323
67	Esophageal varix (HP:0002040)	1.73926595
68	Small epiphyses (HP:0010585)	1.73872716
69	Enlarged kidneys (HP:0000105)	1.72600892
70	Abnormal ossification of hand bones (HP:0005921)	1.69943176
71	Poikilocytosis (HP:0004447)	1.69334508
72	Generalized aminoaciduria (HP:0002909)	1.68294252
73	Abnormal hand bone ossification (HP:0010660)	1.66985496
74	Asymmetry of the thorax (HP:0001555)	1.66212878
75	Gout (HP:0001997)	1.65811726
76	Peritonitis (HP:0002586)	1.64531425
77	* Pulmonary embolism (HP:0002204)	1.61676865
78	Neurofibrillary tangles (HP:0002185)	1.59516501
79	Urinary glycosaminoglycan excretion (HP:0003541)	1.59096291
80	Mucopolysacchariduria (HP:0008155)	1.59096291
81	Alacrima (HP:0000522)	1.58205904
82	Abnormal gallbladder physiology (HP:0012438)	1.56632334
83	Cholecystitis (HP:0001082)	1.56632334
84	Cerebral aneurysm (HP:0004944)	1.55732743
85	Increased serum ferritin (HP:0003281)	1.54604505
86	Widely patent fontanelles and sutures (HP:0004492)	1.54553091
87	Hyperbilirubinemia (HP:0002904)	1.53812509
88	Bronchomalacia (HP:0002780)	1.51332541
89	Hypertriglyceridemia (HP:0002155)	1.50645713
90	Back pain (HP:0003418)	1.49818171
91	Elevated alkaline phosphatase (HP:0003155)	1.48902240
92	Pigmentary retinal degeneration (HP:0001146)	1.48474243
93	Increased serum pyruvate (HP:0003542)	1.47254772
94	Abnormality of iron homeostasis (HP:0011031)	1.46368981
95	Hypophosphatemia (HP:0002148)	1.45513648
96	Abnormality of purine metabolism (HP:0004352)	1.42851035
97	Neonatal onset (HP:0003623)	1.42600066
98	Hypoglycemic coma (HP:0001325)	1.41774913
99	Abnormal enzyme/coenzyme activity (HP:0012379)	1.41662677
100	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.41407908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	5.98017356
2	ERN1	4.03009583
3	RIPK1	3.63137613
4	FGFR3	3.63133864
5	TRIB3	3.28315619
6	ICK	3.09565163
7	SIK1	2.91235932
8	PDGFRA	2.34455113
9	EPHA3	2.03898266
10	AKT3	1.98798284
11	WNK4	1.83004233
12	CDK12	1.81153366
13	MST1R	1.76556486
14	PIK3CA	1.74604827
15	PKN2	1.64301009
16	DDR2	1.61852306
17	TYRO3	1.61203407
18	FGFR2	1.56279209
19	RET	1.51341406
20	PRKAA2	1.50704447
21	NTRK3	1.44885700
22	EPHB1	1.33874681
23	TYK2	1.30982821
24	PDPK1	1.28987451
25	TGFBR2	1.25313724
26	EEF2K	1.24394014
27	ERBB2	1.23077800
28	MET	1.20013873
29	JAK1	1.14944887
30	EPHA2	1.13685841
31	MAP3K2	1.10628777
32	MAPK11	1.07914703
33	FGFR1	1.07867493
34	MAP3K3	1.05161186
35	SGK494	1.04782848
36	SGK223	1.04782848
37	DYRK1B	1.00924327
38	CDC42BPA	0.97795343
39	WNK1	0.96622434
40	FER	0.95848726
41	PDK1	0.86979694
42	MTOR	0.86966735
43	LATS1	0.86503656
44	MAP3K7	0.86434517
45	NTRK1	0.86340762
46	SGK3	0.84290934
47	NEK9	0.81600329
48	NLK	0.81256642
49	MAP3K6	0.80679732
50	MAP3K1	0.80522838
51	SMG1	0.80432057
52	PDGFRB	0.80343893
53	MARK2	0.79786919
54	PRKACG	0.78957593
55	PTK6	0.76556575
56	LATS2	0.76494011
57	MAPKAPK3	0.74462537
58	SGK2	0.73695676
59	PRKAA1	0.70828776
60	PTK2	0.69956870
61	SGK1	0.69347995
62	SIK2	0.62011956
63	LMTK2	0.59463092
64	MAP2K6	0.57440627
65	PRPF4B	0.56065909
66	IGF1R	0.54950675
67	EPHA4	0.53132494
68	CSF1R	0.52577842
69	JAK2	0.52232145
70	STK38	0.51876930
71	NEK6	0.50533399
72	KSR2	0.49868868
73	ZAP70	0.49476827
74	SRC	0.47689805
75	IRAK3	0.47569037
76	CAMK1D	0.47207275
77	PRKCZ	0.46501542
78	MAPK12	0.42605783
79	RPS6KB1	0.42040185
80	MAPK3	0.41914129
81	NTRK2	0.41156959
82	GSK3A	0.40979871
83	MAPK15	0.37366679
84	RPS6KA3	0.35346993
85	CDK6	0.34679974
86	CSNK1E	0.34181953
87	PRKG1	0.34027500
88	MELK	0.33073169
89	MAPK10	0.32703783
90	HIPK2	0.32033418
91	PRKD1	0.31923841
92	MAP2K4	0.31827264
93	CAMK4	0.30957193
94	CDK7	0.29116038
95	FGR	0.28458166
96	MAPK1	0.28180255
97	TBK1	0.27360808
98	MYLK	0.27220748
99	MAP3K5	0.27047937
100	MAPK4	0.24217902

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Complement and coagulation cascades_Homo sapiens_hsa04610	5.16313988
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.08259783
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.07407335
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.93409209
5	Caffeine metabolism_Homo sapiens_hsa00232	2.81145205
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.78687502
7	Retinol metabolism_Homo sapiens_hsa00830	2.70118365
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.69686944
9	Phenylalanine metabolism_Homo sapiens_hsa00360	2.51975861
10	Fatty acid degradation_Homo sapiens_hsa00071	2.51065371
11	Histidine metabolism_Homo sapiens_hsa00340	2.39670665
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.39625100
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.36136373
14	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.25144269
15	Chemical carcinogenesis_Homo sapiens_hsa05204	2.23985053
16	Tyrosine metabolism_Homo sapiens_hsa00350	2.23598421
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.22929384
18	* Staphylococcus aureus infection_Homo sapiens_hsa05150	2.00189026
19	Bile secretion_Homo sapiens_hsa04976	1.95267983
20	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.94506862
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.92381193
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.73662528
23	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.73339371
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.68002157
25	Prion diseases_Homo sapiens_hsa05020	1.61384117
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.58801282
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.57614618
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.54965009
29	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.54153140
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.53517449
31	Butanoate metabolism_Homo sapiens_hsa00650	1.51990297
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.48400053
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.47878871
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.23244281
35	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.21791097
36	ABC transporters_Homo sapiens_hsa02010	1.19402313
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18736022
38	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.15752654
39	Arginine and proline metabolism_Homo sapiens_hsa00330	1.15611024
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.09424101
41	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.07695680
42	Peroxisome_Homo sapiens_hsa04146	1.07360644
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.01906450
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.90556935
45	Other glycan degradation_Homo sapiens_hsa00511	0.88952224
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83438844
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.81607708
48	Propanoate metabolism_Homo sapiens_hsa00640	0.80246305
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78660524
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78403559
51	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.77616671
52	Carbon metabolism_Homo sapiens_hsa01200	0.76688216
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76043522
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75836891
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.74753959
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69143255
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.65190201
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61192691
59	Lysine degradation_Homo sapiens_hsa00310	0.61173514
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60650996
61	* Pertussis_Homo sapiens_hsa05133	0.60421408
62	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.56303496
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53467952
64	Insulin resistance_Homo sapiens_hsa04931	0.51602536
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.50452960
66	One carbon pool by folate_Homo sapiens_hsa00670	0.45863887
67	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.41349922
68	Renin-angiotensin system_Homo sapiens_hsa04614	0.40938291
69	Galactose metabolism_Homo sapiens_hsa00052	0.40107718
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.33063658
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.31420914
72	Metabolic pathways_Homo sapiens_hsa01100	0.27613447
73	Sulfur relay system_Homo sapiens_hsa04122	0.27010004
74	Mineral absorption_Homo sapiens_hsa04978	0.26070668
75	AMPK signaling pathway_Homo sapiens_hsa04152	0.25951409
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23084436
77	Sulfur metabolism_Homo sapiens_hsa00920	0.21321307
78	Amoebiasis_Homo sapiens_hsa05146	0.19816732
79	Fatty acid elongation_Homo sapiens_hsa00062	0.17838584
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.13440405
81	Pentose phosphate pathway_Homo sapiens_hsa00030	0.12958121
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.12756019
83	Insulin signaling pathway_Homo sapiens_hsa04910	0.12549782
84	Protein digestion and absorption_Homo sapiens_hsa04974	0.10549738
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.10022597
86	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.08181091
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.06877235
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.06037743
89	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.04355056
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.02085124
91	Circadian rhythm_Homo sapiens_hsa04710	0.01210026
92	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.01051834
93	Focal adhesion_Homo sapiens_hsa04510	-0.0770764
94	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.0767605
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	-0.0759707
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	-0.0658845
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0647401
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	-0.0519305
99	* Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.0189249
100	Glutathione metabolism_Homo sapiens_hsa00480	-0.0052866

C4A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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