C4BPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)9.37036138
2exogenous drug catabolic process (GO:0042738)9.18078963
3drug catabolic process (GO:0042737)8.75423899
4epoxygenase P450 pathway (GO:0019373)8.64044942
5omega-hydroxylase P450 pathway (GO:0097267)8.59002467
6* regulation of protein activation cascade (GO:2000257)8.46786396
7regulation of fibrinolysis (GO:0051917)8.01835445
8* regulation of complement activation (GO:0030449)7.98193225
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.78230646
10L-phenylalanine catabolic process (GO:0006559)7.78230646
11negative regulation of fibrinolysis (GO:0051918)7.68246815
12glyoxylate metabolic process (GO:0046487)7.50416361
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20337120
14L-phenylalanine metabolic process (GO:0006558)7.20337120
15urea metabolic process (GO:0019627)6.88622907
16ethanol oxidation (GO:0006069)6.68958643
17protein carboxylation (GO:0018214)6.57684342
18peptidyl-glutamic acid carboxylation (GO:0017187)6.57684342
19nitrogen cycle metabolic process (GO:0071941)6.27084184
20drug metabolic process (GO:0017144)6.26357336
21blood coagulation, intrinsic pathway (GO:0007597)6.18237501
22fibrinolysis (GO:0042730)6.14163148
23cellular glucuronidation (GO:0052695)5.96138923
24bile acid biosynthetic process (GO:0006699)5.95817584
25urea cycle (GO:0000050)5.88517583
26oxidative demethylation (GO:0070989)5.81769988
27uronic acid metabolic process (GO:0006063)5.66034255
28glucuronate metabolic process (GO:0019585)5.66034255
29aromatic amino acid family catabolic process (GO:0009074)5.65786315
30* protein activation cascade (GO:0072376)5.63340681
31* complement activation (GO:0006956)5.44459020
32ethanol metabolic process (GO:0006067)5.39508713
33serine family amino acid catabolic process (GO:0009071)5.38365745
34regulation of triglyceride catabolic process (GO:0010896)5.33270992
35bile acid metabolic process (GO:0008206)5.29515499
36* complement activation, classical pathway (GO:0006958)5.29308866
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.14519475
38opsonization (GO:0008228)5.06649068
39acute-phase response (GO:0006953)5.05932143
40imidazole-containing compound metabolic process (GO:0052803)5.01638805
41negative regulation of cholesterol transport (GO:0032375)4.98317244
42negative regulation of sterol transport (GO:0032372)4.98317244
43* regulation of humoral immune response (GO:0002920)4.98213131
44phenylpropanoid metabolic process (GO:0009698)4.97684638
45regulation of plasminogen activation (GO:0010755)4.97322666
46bile acid and bile salt transport (GO:0015721)4.74391982
47glycine metabolic process (GO:0006544)4.69957832
48negative regulation of hemostasis (GO:1900047)4.65184789
49negative regulation of blood coagulation (GO:0030195)4.65184789
50cytolysis (GO:0019835)4.59929300
51tyrosine metabolic process (GO:0006570)4.59710428
52disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.54747489
53killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.54747489
54* negative regulation of protein activation cascade (GO:2000258)4.54522638
55S-adenosylmethionine metabolic process (GO:0046500)4.49964237
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.47398295
57positive regulation of triglyceride lipase activity (GO:0061365)4.38380733
58positive regulation of lipoprotein lipase activity (GO:0051006)4.38380733
59acylglycerol homeostasis (GO:0055090)4.35426389
60triglyceride homeostasis (GO:0070328)4.35426389
61negative regulation of coagulation (GO:0050819)4.24303055
62negative regulation of wound healing (GO:0061045)4.23604759
63hormone catabolic process (GO:0042447)4.21349622
64protein-lipid complex remodeling (GO:0034368)4.17913812
65macromolecular complex remodeling (GO:0034367)4.17913812
66plasma lipoprotein particle remodeling (GO:0034369)4.17913812
67glutamate metabolic process (GO:0006536)4.13414307
68amino-acid betaine metabolic process (GO:0006577)4.07873065
69alkaloid metabolic process (GO:0009820)4.04635914
70cholesterol efflux (GO:0033344)4.04372616
71positive regulation of blood coagulation (GO:0030194)4.03378209
72positive regulation of hemostasis (GO:1900048)4.03378209
73flavonoid metabolic process (GO:0009812)3.88671515
74phospholipid efflux (GO:0033700)3.87681064
75arginine metabolic process (GO:0006525)3.84956252
76intestinal cholesterol absorption (GO:0030299)3.84517045
77alpha-amino acid catabolic process (GO:1901606)3.83930334
78high-density lipoprotein particle remodeling (GO:0034375)3.82304526
79serine family amino acid metabolic process (GO:0009069)3.77626300
80acute inflammatory response (GO:0002526)3.77421269
81indole-containing compound catabolic process (GO:0042436)3.76946909
82indolalkylamine catabolic process (GO:0046218)3.76946909
83tryptophan catabolic process (GO:0006569)3.76946909
84regulation of cholesterol esterification (GO:0010872)3.76839882
85regulation of apoptotic cell clearance (GO:2000425)3.73255805
86positive regulation of coagulation (GO:0050820)3.71889068
87aromatic amino acid family metabolic process (GO:0009072)3.71641334
88negative regulation of lipase activity (GO:0060192)3.67037944
89response to mercury ion (GO:0046689)3.57023267
90* regulation of acute inflammatory response (GO:0002673)3.52153846
91xenobiotic metabolic process (GO:0006805)3.48099347
92reverse cholesterol transport (GO:0043691)3.47153630
93heme transport (GO:0015886)3.46712946
94sodium-independent organic anion transport (GO:0043252)3.45109637
95steroid catabolic process (GO:0006706)3.44845370
96cellular ketone body metabolic process (GO:0046950)3.43545872
97* negative regulation of complement activation (GO:0045916)3.42270026
98positive regulation of fatty acid biosynthetic process (GO:0045723)3.36961720
99serine family amino acid biosynthetic process (GO:0009070)3.34836943
100cysteine metabolic process (GO:0006534)3.34434256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse6.79319845
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.77620764
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.63537970
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.63005295
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.10275988
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.80175337
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.34247878
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.96854283
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85932138
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91174216
11* FOXA2_19822575_ChIP-Seq_HepG2_Human2.17982898
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09679328
13HNF4A_19822575_ChIP-Seq_HepG2_Human2.06141580
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03025023
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0366606
16HTT_18923047_ChIP-ChIP_STHdh_Human1.67233714
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.62509705
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.48409908
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34883190
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.31861925
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31173276
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28693012
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26290333
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25988233
25AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23612359
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22017091
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20898971
28GATA1_22025678_ChIP-Seq_K562_Human1.09043617
29GATA4_25053715_ChIP-Seq_YYC3_Human1.05048739
30* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98834850
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98564653
32NFE2_27457419_Chip-Seq_LIVER_Mouse0.97855225
33* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97540260
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97029364
35PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96975405
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95041524
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94306403
38SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91997759
39CLOCK_20551151_ChIP-Seq_293T_Human0.89666920
40ESR2_21235772_ChIP-Seq_MCF-7_Human0.88957630
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88900971
42* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87460152
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86694258
44* HNFA_21074721_ChIP-Seq_CACO-2_Human0.83657700
45EZH2_27294783_Chip-Seq_NPCs_Mouse0.83279282
46SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82616626
47RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81596267
48* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79697262
49CDX2_20551321_ChIP-Seq_CACO-2_Human0.79669165
50* PHF8_20622853_ChIP-Seq_HELA_Human0.79387475
51BCAT_22108803_ChIP-Seq_LS180_Human0.78400493
52FOXA1_25552417_ChIP-Seq_VCAP_Human0.77410684
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76675711
54SOX2_20726797_ChIP-Seq_SW620_Human0.76193016
55CBP_21632823_ChIP-Seq_H3396_Human0.75039297
56TP53_18474530_ChIP-ChIP_U2OS_Human0.74057917
57KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73981065
58RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73191891
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72682684
60PIAS1_25552417_ChIP-Seq_VCAP_Human0.72265909
61* GATA6_21074721_ChIP-Seq_CACO-2_Human0.71671722
62SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71237533
63AR_20517297_ChIP-Seq_VCAP_Human0.69596118
64* NFYA_21822215_ChIP-Seq_K562_Human0.67878308
65CEBPB_22108803_ChIP-Seq_LS180_Human0.67195922
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66705987
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66478957
68SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.66072104
69CRX_20693478_ChIP-Seq_RETINA_Mouse0.64691062
70* TCF4_18268006_ChIP-ChIP_LS174T_Human0.64174744
71OCT4_18555785_Chip-Seq_ESCs_Mouse0.63045193
72* GATA6_25053715_ChIP-Seq_YYC3_Human0.62943134
73FOXO3_23340844_ChIP-Seq_DLD1_Human0.62307367
74OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61308486
75POU3F2_20337985_ChIP-ChIP_501MEL_Human0.61007351
76RUNX1_27457419_Chip-Seq_LIVER_Mouse0.60175589
77* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.59445929
78IRF1_19129219_ChIP-ChIP_H3396_Human0.59328180
79SOX2_21211035_ChIP-Seq_LN229_Human0.59000810
80SMAD1_18555785_Chip-Seq_ESCs_Mouse0.58691010
81* ETV1_20927104_ChIP-Seq_GIST48_Human0.58507631
82ESR1_21235772_ChIP-Seq_MCF-7_Human0.58357474
83ESRRB_18555785_Chip-Seq_ESCs_Mouse0.56932492
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.56845417
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.56623507
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56502541
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56502541
88PU1_27457419_Chip-Seq_LIVER_Mouse0.56132701
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54499382
90CDX2_22108803_ChIP-Seq_LS180_Human0.54282028
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.54071496
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.51451604
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.50604944
94* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.50325915
95KLF4_18555785_Chip-Seq_ESCs_Mouse0.49910393
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48874107
97RAC3_21632823_ChIP-Seq_H3396_Human0.48638871
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.48105191
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.45725953
100ER_23166858_ChIP-Seq_MCF-7_Human0.45699060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.30633188
2MP0005085_abnormal_gallbladder_physiolo6.48835892
3MP0005360_urolithiasis5.93059929
4MP0008875_abnormal_xenobiotic_pharmacok5.85760887
5MP0005365_abnormal_bile_salt5.77423619
6MP0003195_calcinosis4.74888988
7MP0002138_abnormal_hepatobiliary_system4.52275784
8MP0003252_abnormal_bile_duct4.29992654
9MP0001666_abnormal_nutrient_absorption3.30831300
10MP0003868_abnormal_feces_composition3.28831195
11MP0010329_abnormal_lipoprotein_level2.74832120
12MP0003191_abnormal_cellular_cholesterol2.70310074
13MP0009697_abnormal_copulation2.55188782
14MP0005332_abnormal_amino_acid2.42412899
15MP0003806_abnormal_nucleotide_metabolis2.11471295
16MP0010368_abnormal_lymphatic_system1.99104197
17MP0009840_abnormal_foam_cell1.88435935
18MP0000609_abnormal_liver_physiology1.87733091
19MP0004782_abnormal_surfactant_physiolog1.83015566
20MP0002118_abnormal_lipid_homeostasis1.78838392
21MP0002876_abnormal_thyroid_physiology1.69384978
22MP0001764_abnormal_homeostasis1.52845742
23MP0004019_abnormal_vitamin_homeostasis1.35706157
24MP0001661_extended_life_span1.30663383
25MP0002132_abnormal_respiratory_system1.30464366
26MP0005670_abnormal_white_adipose1.18957849
27MP0005408_hypopigmentation1.18887705
28MP0003656_abnormal_erythrocyte_physiolo1.14559048
29MP0005319_abnormal_enzyme/_coenzyme1.11192876
30MP0000598_abnormal_liver_morphology1.06185592
31MP0009643_abnormal_urine_homeostasis1.04044753
32MP0005584_abnormal_enzyme/coenzyme_acti1.02596007
33MP0009764_decreased_sensitivity_to1.02019465
34MP0009053_abnormal_anal_canal0.99812149
35MP0009763_increased_sensitivity_to0.93184222
36MP0000604_amyloidosis0.91742678
37MP0001915_intracranial_hemorrhage0.90304351
38MP0008469_abnormal_protein_level0.88426682
39MP0009642_abnormal_blood_homeostasis0.86110799
40MP0005376_homeostasis/metabolism_phenot0.84929022
41MP0002971_abnormal_brown_adipose0.82073846
42MP0003690_abnormal_glial_cell0.78079878
43MP0005451_abnormal_body_composition0.76115574
44MP0005395_other_phenotype0.75925454
45MP0003186_abnormal_redox_activity0.75446357
46MP0005636_abnormal_mineral_homeostasis0.72262153
47MP0005187_abnormal_penis_morphology0.70926996
48MP0002282_abnormal_trachea_morphology0.70547231
49MP0002168_other_aberrant_phenotype0.68540882
50MP0005464_abnormal_platelet_physiology0.66014662
51MP0009785_altered_susceptibility_to0.64404717
52MP0005023_abnormal_wound_healing0.63910549
53MP0003638_abnormal_response/metabolism_0.61491228
54MP0008872_abnormal_physiological_respon0.60734684
55MP0003879_abnormal_hair_cell0.60558206
56MP0005164_abnormal_response_to0.60202612
57MP0005058_abnormal_lysosome_morphology0.58864781
58MP0005535_abnormal_body_temperature0.58386091
59MP0008874_decreased_physiological_sensi0.58299442
60MP0005083_abnormal_biliary_tract0.58155109
61MP0004883_abnormal_blood_vessel0.58033488
62MP0002078_abnormal_glucose_homeostasis0.57502724
63MP0001881_abnormal_mammary_gland0.52906165
64MP0005266_abnormal_metabolism0.52900734
65MP0000249_abnormal_blood_vessel0.52749958
66MP0001851_eye_inflammation0.51712040
67MP0005166_decreased_susceptibility_to0.51025891
68MP0005334_abnormal_fat_pad0.50968113
69MP0004130_abnormal_muscle_cell0.50254200
70MP0009765_abnormal_xenobiotic_induced0.47713181
71MP0003011_delayed_dark_adaptation0.45793035
72MP0003075_altered_response_to0.43769130
73MP0002136_abnormal_kidney_physiology0.42969784
74MP0001958_emphysema0.41885502
75MP0002249_abnormal_larynx_morphology0.38280953
76MP0005448_abnormal_energy_balance0.33160371
77MP0002332_abnormal_exercise_endurance0.32430017
78MP0005647_abnormal_sex_gland0.31166552
79MP0009115_abnormal_fat_cell0.30703300
80MP0001845_abnormal_inflammatory_respons0.30459954
81MP0000639_abnormal_adrenal_gland0.29666944
82MP0001756_abnormal_urination0.29665789
83MP0002295_abnormal_pulmonary_circulatio0.28871242
84MP0005397_hematopoietic_system_phenotyp0.28297847
85MP0001545_abnormal_hematopoietic_system0.28297847
86MP0006036_abnormal_mitochondrial_physio0.28255243
87MP0000566_synostosis0.28193524
88MP0003436_decreased_susceptibility_to0.28007015
89MP0005220_abnormal_exocrine_pancreas0.27410828
90MP0003953_abnormal_hormone_level0.26574627
91MP0002128_abnormal_blood_circulation0.25099866
92MP0004272_abnormal_basement_membrane0.24020804
93MP0005167_abnormal_blood-brain_barrier0.23572072
94MP0002419_abnormal_innate_immunity0.23510655
95MP0008873_increased_physiological_sensi0.22984734
96MP0003718_maternal_effect0.22559632
97MP0003705_abnormal_hypodermis_morpholog0.21930206
98MP0005025_abnormal_response_to0.21854031
99MP0000920_abnormal_myelination0.21437267
100MP0002135_abnormal_kidney_morphology0.20637595

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.80713323
2Prolonged partial thromboplastin time (HP:0003645)8.90013949
3Abnormality of complement system (HP:0005339)8.50313305
4Abnormality of aromatic amino acid family metabolism (HP:0004338)7.98593971
5Hypobetalipoproteinemia (HP:0003563)7.50417239
6Conjugated hyperbilirubinemia (HP:0002908)7.00666432
7Systemic lupus erythematosus (HP:0002725)6.73783577
8Joint hemorrhage (HP:0005261)6.34355650
9Glomerulonephritis (HP:0000099)6.10359402
10Hyperlipoproteinemia (HP:0010980)5.46757524
11Intrahepatic cholestasis (HP:0001406)5.42436915
12Abnormality of the common coagulation pathway (HP:0010990)5.09821592
13Recurrent gram-negative bacterial infections (HP:0005420)5.02779371
14Spontaneous abortion (HP:0005268)4.73070863
15Abnormality of pyrimidine metabolism (HP:0004353)4.72952069
16Xanthomatosis (HP:0000991)4.64935194
17Nephritis (HP:0000123)4.42331476
18Hypolipoproteinemia (HP:0010981)4.36447377
19Abnormality of the intrinsic pathway (HP:0010989)4.19481462
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.80247976
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.36239574
22Hypoalphalipoproteinemia (HP:0003233)3.34803664
23Fat malabsorption (HP:0002630)3.31392890
24Gingival bleeding (HP:0000225)3.22936612
25Abnormality of methionine metabolism (HP:0010901)3.20923065
26Hyperammonemia (HP:0001987)3.05739554
27Hyperglycinemia (HP:0002154)2.86013671
28Hypercholesterolemia (HP:0003124)2.84328023
29Abnormality of nucleobase metabolism (HP:0010932)2.74492194
30Thrombophlebitis (HP:0004418)2.74173907
31Epidermoid cyst (HP:0200040)2.73304794
32Osteomalacia (HP:0002749)2.66847392
33Mitral stenosis (HP:0001718)2.66099461
34Hepatocellular carcinoma (HP:0001402)2.65592044
35Generalized aminoaciduria (HP:0002909)2.63162320
36Purpura (HP:0000979)2.59501179
37Vascular calcification (HP:0004934)2.59181953
38Delayed CNS myelination (HP:0002188)2.55777803
39Hyperbilirubinemia (HP:0002904)2.52409134
40Hemorrhage of the eye (HP:0011885)2.50979006
41Fair hair (HP:0002286)2.47858369
42Pulmonary embolism (HP:0002204)2.46977009
43Abnormality of serine family amino acid metabolism (HP:0010894)2.45346959
44Abnormality of glycine metabolism (HP:0010895)2.45346959
45Rickets (HP:0002748)2.45163808
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45104518
47Menorrhagia (HP:0000132)2.40511177
48Steatorrhea (HP:0002570)2.40471068
49Reduced antithrombin III activity (HP:0001976)2.40123331
50Abnormality of serum amino acid levels (HP:0003112)2.35581136
51Cardiovascular calcification (HP:0011915)2.28468451
52Neonatal hypoglycemia (HP:0001998)2.24588459
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.22090719
54Cholelithiasis (HP:0001081)2.11422776
55Joint swelling (HP:0001386)2.09864474
56Hyperglycinuria (HP:0003108)2.07188116
57Complement deficiency (HP:0004431)10.5847876
58Deep venous thrombosis (HP:0002625)10.0266555
59Metabolic acidosis (HP:0001942)1.99852930
60Elevated alkaline phosphatase (HP:0003155)1.99470455
61Arthropathy (HP:0003040)1.97701659
62Abnormal gallbladder morphology (HP:0012437)1.97435306
63Abnormality of iron homeostasis (HP:0011031)1.95243134
64Myocardial infarction (HP:0001658)1.94961357
65Increased serum ferritin (HP:0003281)1.93905876
66Cholecystitis (HP:0001082)1.90138059
67Abnormal gallbladder physiology (HP:0012438)1.90138059
68Ketosis (HP:0001946)1.88685353
69Abnormal enzyme/coenzyme activity (HP:0012379)1.88564063
70Gout (HP:0001997)1.87436068
71Abnormality of alkaline phosphatase activity (HP:0004379)1.84072889
72Abnormality of purine metabolism (HP:0004352)1.83531419
73Epistaxis (HP:0000421)1.83489798
74Interstitial pulmonary disease (HP:0006530)1.81689223
75Abnormality of transition element cation homeostasis (HP:0011030)1.81423440
76Generalized hypopigmentation of hair (HP:0011358)1.79011419
77Irritability (HP:0000737)1.78336898
78Abnormality of the Achilles tendon (HP:0005109)1.77096903
79Gangrene (HP:0100758)1.76081720
80Abnormality of vitamin metabolism (HP:0100508)1.73310284
81Skin nodule (HP:0200036)1.72654806
82Hyperphosphaturia (HP:0003109)1.71817773
83Cerebral palsy (HP:0100021)1.65636169
84Alkalosis (HP:0001948)1.62001566
85Abnormal delivery (HP:0001787)1.59604569
86Hypophosphatemic rickets (HP:0004912)1.57348850
87Abnormality of urine glucose concentration (HP:0011016)1.56419844
88Glycosuria (HP:0003076)1.56419844
89Blue irides (HP:0000635)1.56121878
90Abnormal biliary tract physiology (HP:0012439)1.54958609
91Bile duct proliferation (HP:0001408)1.54958609
92Amyloidosis (HP:0011034)1.54920949
93Atrioventricular block (HP:0001678)1.53589102
94Bifid scrotum (HP:0000048)1.50475163
95Poikilocytosis (HP:0004447)1.49323993
96Enlarged kidneys (HP:0000105)1.49020854
97Increased mean platelet volume (HP:0011877)1.48949908
98Pancreatitis (HP:0001733)1.48876880
99Increased serum pyruvate (HP:0003542)1.46754732
100Hydroxyprolinuria (HP:0003080)1.42882454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.59319622
2ERN14.41408163
3PDK23.23230037
4EPHA33.00900172
5RIPK13.00588035
6MST1R2.99189904
7PIK3CG2.92646655
8TYK22.66885212
9FGFR32.60258749
10TRIB32.21927542
11PIK3CA2.18532191
12TGFBR21.84991288
13PRKACG1.80896165
14EPHB11.75102153
15SIK11.71923969
16JAK11.67224462
17NLK1.65121456
18PDPK11.60983508
19PRKAA21.60289801
20TAOK31.60175649
21NEK91.59108427
22BCKDK1.54700584
23FER1.49580107
24LATS11.47740654
25MAPK111.45134123
26ZAP701.44522563
27MET1.30044521
28IGF1R1.29219162
29MAP3K31.27071002
30MAP2K41.26674725
31PRPF4B1.21891841
32TIE11.18393414
33NTRK31.13614073
34MAP3K61.11378616
35TBK11.10870352
36ICK1.08435415
37PDK11.05736965
38JAK21.03991664
39AKT31.03683744
40PKN21.03599560
41MAP3K21.00711605
42MAP3K11.00118234
43CAMKK20.99457050
44RET0.97303516
45CDK60.97100853
46ERBB20.89658456
47ABL20.89534634
48BRSK20.87861592
49PRKCG0.80469137
50PRKCZ0.75815546
51MYLK0.73090707
52PRKG10.72810654
53TNK20.71930075
54MAPK120.67732027
55PRKACA0.65415573
56MAPKAPK30.61811139
57IRAK10.61807709
58KDR0.61254223
59GSK3A0.60736145
60MAPK70.60271980
61PDGFRB0.59340449
62CSF1R0.58921676
63MAP3K120.56118088
64STK380.55569165
65PRKAA10.54217269
66SGK30.52505571
67PRKCA0.50047008
68SGK10.50044525
69PRKACB0.50009992
70SGK20.49120336
71NEK60.48731075
72DAPK20.48376247
73MAP2K30.48080336
74ERBB40.47708371
75BLK0.47520541
76PINK10.47099502
77SGK4940.46487398
78SGK2230.46487398
79SRC0.45441280
80LRRK20.45013669
81INSRR0.44811782
82RPS6KA30.44505021
83MAPK40.44481791
84PDGFRA0.43494028
85CSNK1D0.43017592
86CSNK1E0.42145658
87PTK60.41523433
88MAP2K60.41100122
89STK38L0.41081565
90CAMKK10.41038110
91PRKCB0.40935657
92MAP3K130.38262014
93MAPK30.37927825
94EPHA20.37734724
95MAP3K70.36798103
96RPS6KB10.34356331
97MAP3K50.32781247
98EPHA40.32740092
99TRPM70.32520000
100PRKD10.32501205

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.40872655
2* Complement and coagulation cascades_Homo sapiens_hsa046104.22678002
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.20522219
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.86446763
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.45422089
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41127132
7Retinol metabolism_Homo sapiens_hsa008303.32521903
8Chemical carcinogenesis_Homo sapiens_hsa052042.80379645
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.79320991
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.63074765
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61873464
12Arginine biosynthesis_Homo sapiens_hsa002202.57773101
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.56063484
14Phenylalanine metabolism_Homo sapiens_hsa003602.51283943
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.44584551
16Fatty acid degradation_Homo sapiens_hsa000712.43409313
17Tyrosine metabolism_Homo sapiens_hsa003502.33772294
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06335361
19Histidine metabolism_Homo sapiens_hsa003402.05241459
20Linoleic acid metabolism_Homo sapiens_hsa005911.93468703
21Tryptophan metabolism_Homo sapiens_hsa003801.80588733
22Bile secretion_Homo sapiens_hsa049761.78042903
23Butanoate metabolism_Homo sapiens_hsa006501.77377875
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.73608389
25Staphylococcus aureus infection_Homo sapiens_hsa051501.66773818
26Starch and sucrose metabolism_Homo sapiens_hsa005001.59325189
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48226912
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44663155
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41983386
30Prion diseases_Homo sapiens_hsa050201.40122716
31PPAR signaling pathway_Homo sapiens_hsa033201.38455480
32Vitamin B6 metabolism_Homo sapiens_hsa007501.33640077
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.29897177
34Peroxisome_Homo sapiens_hsa041461.25126538
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.23861732
36beta-Alanine metabolism_Homo sapiens_hsa004101.19799927
37Arachidonic acid metabolism_Homo sapiens_hsa005901.19750361
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10745761
39Biosynthesis of amino acids_Homo sapiens_hsa012301.08868534
40Pyruvate metabolism_Homo sapiens_hsa006201.01855654
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01782232
42ABC transporters_Homo sapiens_hsa020100.91726114
43Arginine and proline metabolism_Homo sapiens_hsa003300.89931625
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89915691
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83528857
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83429552
47Propanoate metabolism_Homo sapiens_hsa006400.82566790
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82354961
49Carbon metabolism_Homo sapiens_hsa012000.79535482
50Fat digestion and absorption_Homo sapiens_hsa049750.77355240
51One carbon pool by folate_Homo sapiens_hsa006700.69639897
52Fatty acid metabolism_Homo sapiens_hsa012120.69420709
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69375124
54Sulfur metabolism_Homo sapiens_hsa009200.55103911
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54410601
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.52118269
57* Pertussis_Homo sapiens_hsa051330.41957769
58Lysine degradation_Homo sapiens_hsa003100.41349106
59Metabolic pathways_Homo sapiens_hsa011000.39871102
60Sulfur relay system_Homo sapiens_hsa041220.37695065
61Fatty acid biosynthesis_Homo sapiens_hsa000610.30660480
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28708351
63Glycerolipid metabolism_Homo sapiens_hsa005610.28599305
64Insulin resistance_Homo sapiens_hsa049310.26874338
65Systemic lupus erythematosus_Homo sapiens_hsa053220.20366883
66Fructose and mannose metabolism_Homo sapiens_hsa000510.20091934
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.19362336
68Pentose phosphate pathway_Homo sapiens_hsa000300.18761419
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17553678
70Glucagon signaling pathway_Homo sapiens_hsa049220.15294737
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.12445985
72Fatty acid elongation_Homo sapiens_hsa000620.09936539
73Galactose metabolism_Homo sapiens_hsa000520.09801255
74Vitamin digestion and absorption_Homo sapiens_hsa049770.08315777
75Other glycan degradation_Homo sapiens_hsa005110.07922245
76Mineral absorption_Homo sapiens_hsa049780.05846107
77Amoebiasis_Homo sapiens_hsa051460.04660015
78Steroid biosynthesis_Homo sapiens_hsa001000.04531512
79Selenocompound metabolism_Homo sapiens_hsa004500.04209389
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03492295
81Renin-angiotensin system_Homo sapiens_hsa046140.01755405
82Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2261411
83N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2158936
84Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2107749
85Ether lipid metabolism_Homo sapiens_hsa00565-0.2098771
86Phagosome_Homo sapiens_hsa04145-0.2051694
87Lysosome_Homo sapiens_hsa04142-0.1920957
88Insulin signaling pathway_Homo sapiens_hsa04910-0.1603433
89Sphingolipid metabolism_Homo sapiens_hsa00600-0.1596861
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1567252
91Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1502607
92Circadian rhythm_Homo sapiens_hsa04710-0.1391611
93African trypanosomiasis_Homo sapiens_hsa05143-0.0934378
94Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0929137
95Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0395035
96Nitrogen metabolism_Homo sapiens_hsa00910-0.0390542
97Folate biosynthesis_Homo sapiens_hsa00790-0.0135488
98Glutathione metabolism_Homo sapiens_hsa00480-0.0135236
99Serotonergic synapse_Homo sapiens_hsa04726-0.0102871
100AMPK signaling pathway_Homo sapiens_hsa04152-0.0072311

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