C4BPAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.77329072
2multicellular organism reproduction (GO:0032504)8.37916369
3spermatid development (GO:0007286)8.31897442
4binding of sperm to zona pellucida (GO:0007339)8.18871506
5sperm-egg recognition (GO:0035036)7.84772238
6plasma membrane fusion (GO:0045026)7.45308577
7reproduction (GO:0000003)7.01851688
8response to pheromone (GO:0019236)6.83765992
9chromosome condensation (GO:0030261)6.79540649
10axonemal dynein complex assembly (GO:0070286)6.73993020
11cell-cell recognition (GO:0009988)6.62057485
12motile cilium assembly (GO:0044458)6.52724726
13sperm capacitation (GO:0048240)6.44387127
14coenzyme catabolic process (GO:0009109)6.40682614
15microtubule depolymerization (GO:0007019)6.39886558
16regulation of phosphoprotein phosphatase activity (GO:0043666)6.37437583
17DNA packaging (GO:0006323)6.26148977
18calcium ion-dependent exocytosis (GO:0017156)6.17382031
19spermatid nucleus differentiation (GO:0007289)6.00798030
20single strand break repair (GO:0000012)5.70517933
21negative regulation of inclusion body assembly (GO:0090084)5.69877999
22single fertilization (GO:0007338)5.69229581
23rRNA methylation (GO:0031167)5.48560040
24cellular ketone body metabolic process (GO:0046950)5.30701804
25phosphatidylethanolamine biosynthetic process (GO:0006646)5.01859313
26male meiosis (GO:0007140)4.97903811
27spermatogenesis (GO:0007283)4.93246989
28male gamete generation (GO:0048232)4.91412914
29positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.87687972
30epithelial cilium movement (GO:0003351)4.82535332
31cilium or flagellum-dependent cell motility (GO:0001539)4.76307694
32microtubule polymerization or depolymerization (GO:0031109)4.71817851
33germ cell development (GO:0007281)4.69099026
34positive regulation of catecholamine secretion (GO:0033605)4.68359393
35ketone body metabolic process (GO:1902224)4.64863503
36regulation of inclusion body assembly (GO:0090083)4.57808104
37organic cation transport (GO:0015695)4.57311314
38phosphatidylethanolamine metabolic process (GO:0046337)4.56146470
39gamete generation (GO:0007276)4.50114098
40cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.41679986
41protein polyglutamylation (GO:0018095)4.41372685
42rRNA modification (GO:0000154)4.41257284
43sexual reproduction (GO:0019953)4.39139908
44protein-DNA complex disassembly (GO:0032986)4.30705866
45nucleosome disassembly (GO:0006337)4.30705866
46polyamine biosynthetic process (GO:0006596)4.29361114
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.27808259
48detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.22667235
49centriole assembly (GO:0098534)4.18268934
50fertilization (GO:0009566)4.13511692
51protein targeting to Golgi (GO:0000042)4.07414628
52cilium movement (GO:0003341)4.04620632
53negative regulation of Rho protein signal transduction (GO:0035024)4.02379809
54microtubule severing (GO:0051013)3.97897370
55establishment of protein localization to Golgi (GO:0072600)3.91349958
56positive regulation of Rab GTPase activity (GO:0032851)3.82208654
57regulation of Rab GTPase activity (GO:0032313)3.82208654
58response to acidic pH (GO:0010447)3.77025632
59cofactor catabolic process (GO:0051187)3.73740072
60regulation of cilium movement (GO:0003352)3.71432483
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67611696
62multicellular organismal reproductive process (GO:0048609)3.63670057
63retrograde transport, vesicle recycling within Golgi (GO:0000301)3.63458408
64peptidyl-threonine dephosphorylation (GO:0035970)3.57105913
65cellular zinc ion homeostasis (GO:0006882)3.55207940
66regulation of transcription involved in cell fate commitment (GO:0060850)3.43633800
67ventricular system development (GO:0021591)3.40598684
68activation of protein kinase B activity (GO:0032148)3.40078518
69relaxation of smooth muscle (GO:0044557)3.33738912
70centriole replication (GO:0007099)3.25806787
71chromatin silencing (GO:0006342)3.24663034
72cell recognition (GO:0008037)3.22196386
73cGMP-mediated signaling (GO:0019934)3.17590509
74positive regulation of glycolytic process (GO:0045821)3.14952331
75protein localization to Golgi apparatus (GO:0034067)3.14681780
76regulation of oxidative stress-induced neuron death (GO:1903203)3.13741451
77cellular biogenic amine biosynthetic process (GO:0042401)3.08766823
78amine biosynthetic process (GO:0009309)3.08029737
79cellular response to pH (GO:0071467)3.07709164
80regulation of ARF GTPase activity (GO:0032312)3.05106243
81histone H3-K9 demethylation (GO:0033169)3.03167303
82male sex determination (GO:0030238)2.97650223
83zinc ion homeostasis (GO:0055069)2.96616074
84mitochondrion degradation (GO:0000422)2.89352859
85histone exchange (GO:0043486)2.88953283
86regulation of oxidative phosphorylation (GO:0002082)2.88173258
87potassium ion export (GO:0071435)2.87362654
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86305854
89nucleus organization (GO:0006997)2.85015056
90Leydig cell differentiation (GO:0033327)2.84921907
91outflow tract septum morphogenesis (GO:0003148)2.83801506
92glycerol ether metabolic process (GO:0006662)2.81817626
93glomerular visceral epithelial cell development (GO:0072015)2.74721646
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.73663551
95detection of chemical stimulus involved in sensory perception (GO:0050907)2.73631821
96regulation of protein kinase C signaling (GO:0090036)2.73610226
97glandular epithelial cell development (GO:0002068)2.72489908
98cell wall macromolecule metabolic process (GO:0044036)2.68976564
99acrosome reaction (GO:0007340)11.7270284
100sperm motility (GO:0030317)10.4362298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.27488904
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.18185187
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.77382193
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74588484
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.65331621
6FUS_26573619_Chip-Seq_HEK293_Human2.63527205
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62122771
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.44152118
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.41956864
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35619685
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.35619685
12ARNT_22903824_ChIP-Seq_MCF-7_Human2.21520519
13ER_23166858_ChIP-Seq_MCF-7_Human2.20644319
14CBP_20019798_ChIP-Seq_JUKART_Human2.18828592
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.18828592
16VDR_22108803_ChIP-Seq_LS180_Human2.11178866
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.06702410
18GBX2_23144817_ChIP-Seq_PC3_Human2.04749560
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.02098819
20ERA_21632823_ChIP-Seq_H3396_Human1.93830388
21IGF1R_20145208_ChIP-Seq_DFB_Human1.90560912
22NANOG_20526341_ChIP-Seq_ESCs_Human1.88419111
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.85001335
24RAC3_21632823_ChIP-Seq_H3396_Human1.81370341
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76775511
26P300_19829295_ChIP-Seq_ESCs_Human1.73326009
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.70137926
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69816466
29AHR_22903824_ChIP-Seq_MCF-7_Human1.67341284
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.67295046
31TP53_18474530_ChIP-ChIP_U2OS_Human1.66752583
32AR_25329375_ChIP-Seq_VCAP_Human1.63915067
33KLF5_20875108_ChIP-Seq_MESCs_Mouse1.63387012
34MYC_19829295_ChIP-Seq_ESCs_Human1.62317048
35AR_21572438_ChIP-Seq_LNCaP_Human1.57846097
36OCT4_20526341_ChIP-Seq_ESCs_Human1.54021467
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.53614362
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51327527
39EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.49308792
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48384541
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46711694
42TBL1_22424771_ChIP-Seq_293T_Human1.45480483
43CTCF_27219007_Chip-Seq_Bcells_Human1.45217155
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41411751
45SMAD4_21799915_ChIP-Seq_A2780_Human1.39111580
46OCT1_27270436_Chip-Seq_PROSTATE_Human1.39015694
47STAT3_23295773_ChIP-Seq_U87_Human1.36514119
48SMC4_20622854_ChIP-Seq_HELA_Human1.35857112
49RUNX2_22187159_ChIP-Seq_PCA_Human1.35088914
50HOXB7_26014856_ChIP-Seq_BT474_Human1.34777891
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31232971
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29748569
53ERG_20517297_ChIP-Seq_VCAP_Human1.29515141
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.29368105
55NANOG_19829295_ChIP-Seq_ESCs_Human1.28177387
56SOX2_19829295_ChIP-Seq_ESCs_Human1.28177387
57CTCF_20526341_ChIP-Seq_ESCs_Human1.28005560
58CJUN_26792858_Chip-Seq_BT549_Human1.26955055
59ZNF274_21170338_ChIP-Seq_K562_Hela1.25001750
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24424987
61NFYB_21822215_ChIP-Seq_K562_Human1.22283871
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.21877630
63PHF8_20622853_ChIP-Seq_HELA_Human1.21525191
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19397252
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17767602
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15018227
67RXR_22108803_ChIP-Seq_LS180_Human1.14604940
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11096941
69E2F1_20622854_ChIP-Seq_HELA_Human1.08724351
70TCF4_22108803_ChIP-Seq_LS180_Human1.08587384
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08354750
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.08336090
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08046693
74RBPJ_21746931_ChIP-Seq_IB4_Human1.06725980
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05422386
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04833592
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04346821
78TP63_22573176_ChIP-Seq_HFKS_Human1.04334914
79ETV1_20927104_ChIP-Seq_GIST48_Human1.03665014
80TAF2_19829295_ChIP-Seq_ESCs_Human1.02528848
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02446847
82TAF15_26573619_Chip-Seq_HEK293_Human1.01024518
83NCOR_22424771_ChIP-Seq_293T_Human1.00904176
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.00620548
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.99965818
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.99363677
87PHF8_20622854_ChIP-Seq_HELA_Human0.98827109
88E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97025543
89BCAT_22108803_ChIP-Seq_LS180_Human0.96967666
90P300_27268052_Chip-Seq_Bcells_Human0.96681073
91DROSHA_22980978_ChIP-Seq_HELA_Human0.96610846
92CBP_21632823_ChIP-Seq_H3396_Human0.96511111
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.95906740
94TCF4_23295773_ChIP-Seq_U87_Human0.95581855
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.95562087
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95058829
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94457826
98NFYA_21822215_ChIP-Seq_K562_Human0.92894663
99CDX2_22108803_ChIP-Seq_LS180_Human0.91878745
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91603942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive3.86777573
2MP0001929_abnormal_gametogenesis3.44329246
3MP0005248_abnormal_Harderian_gland3.19381828
4MP0003315_abnormal_perineum_morphology2.92966574
5MP0002132_abnormal_respiratory_system2.81484022
6MP0001984_abnormal_olfaction2.63923764
7MP0003878_abnormal_ear_physiology2.61614186
8MP0005377_hearing/vestibular/ear_phenot2.61614186
9MP0008004_abnormal_stomach_pH2.56523081
10MP0002160_abnormal_reproductive_system2.18465407
11MP0003718_maternal_effect2.10916972
12MP0002161_abnormal_fertility/fecundity2.08168621
13MP0009697_abnormal_copulation2.03617597
14MP0000678_abnormal_parathyroid_gland2.01073151
15MP0003136_yellow_coat_color2.00379870
16MP0002249_abnormal_larynx_morphology2.00296083
17MP0005410_abnormal_fertilization11.3651890
18MP0003011_delayed_dark_adaptation1.83797121
19MP0001348_abnormal_lacrimal_gland1.78081797
20MP0005670_abnormal_white_adipose1.75543563
21MP0005360_urolithiasis1.63135103
22MP0010368_abnormal_lymphatic_system1.55012635
23MP0002282_abnormal_trachea_morphology1.52574000
24MP0002210_abnormal_sex_determination1.50129411
25MP0010030_abnormal_orbit_morphology1.48947888
26MP0001661_extended_life_span1.38986456
27MP0006072_abnormal_retinal_apoptosis1.38581664
28MP0001145_abnormal_male_reproductive1.34369911
29MP0003879_abnormal_hair_cell1.33977203
30MP0010386_abnormal_urinary_bladder1.33914867
31MP0005253_abnormal_eye_physiology1.33001861
32MP0001905_abnormal_dopamine_level1.29074462
33MP0001968_abnormal_touch/_nociception1.24981525
34MP0000534_abnormal_ureter_morphology1.24531162
35MP0005423_abnormal_somatic_nervous1.21104390
36MP0001486_abnormal_startle_reflex1.20586524
37MP0003806_abnormal_nucleotide_metabolis1.19686195
38MP0000653_abnormal_sex_gland1.19509029
39MP0003646_muscle_fatigue1.19378180
40MP0001485_abnormal_pinna_reflex1.19340666
41MP0005379_endocrine/exocrine_gland_phen1.13650300
42MP0002127_abnormal_cardiovascular_syste1.13519235
43MP0001188_hyperpigmentation1.13235419
44MP0005395_other_phenotype1.10055413
45MP0009780_abnormal_chondrocyte_physiolo1.09756487
46MP0004085_abnormal_heartbeat1.09040989
47MP0001501_abnormal_sleep_pattern1.08253302
48MP0004084_abnormal_cardiac_muscle1.07414565
49MP0005647_abnormal_sex_gland1.06460240
50MP0010234_abnormal_vibrissa_follicle1.06423656
51MP0004036_abnormal_muscle_relaxation1.01787549
52MP0005551_abnormal_eye_electrophysiolog1.01608515
53MP0001664_abnormal_digestion0.99560347
54MP0002234_abnormal_pharynx_morphology0.94046157
55MP0004742_abnormal_vestibular_system0.93595571
56MP0003632_abnormal_nervous_system0.93151266
57MP0005389_reproductive_system_phenotype0.92447959
58MP0000749_muscle_degeneration0.88319870
59MP0008995_early_reproductive_senescence0.86791376
60MP0004510_myositis0.86548292
61MP0005595_abnormal_vascular_smooth0.86138414
62MP0001765_abnormal_ion_homeostasis0.84347886
63MP0005187_abnormal_penis_morphology0.80551164
64MP0000230_abnormal_systemic_arterial0.80522920
65MP0003045_fibrosis0.79349832
66MP0000026_abnormal_inner_ear0.76708503
67MP0002229_neurodegeneration0.75447706
68MP0003631_nervous_system_phenotype0.73751929
69MP0008775_abnormal_heart_ventricle0.73732104
70MP0000613_abnormal_salivary_gland0.72389600
71MP0003880_abnormal_central_pattern0.72092056
72MP0001963_abnormal_hearing_physiology0.71777654
73MP0004484_altered_response_of0.71675458
74MP0006036_abnormal_mitochondrial_physio0.70014385
75MP0002067_abnormal_sensory_capabilities0.67606619
76MP0003936_abnormal_reproductive_system0.67434046
77MP0005332_abnormal_amino_acid0.66028396
78MP0000538_abnormal_urinary_bladder0.65844146
79MP0002108_abnormal_muscle_morphology0.65229364
80MP0002272_abnormal_nervous_system0.61653629
81MP0002269_muscular_atrophy0.59304199
82MP0002233_abnormal_nose_morphology0.58332152
83MP0001270_distended_abdomen0.58106742
84MP0003633_abnormal_nervous_system0.56751197
85MP0005623_abnormal_meninges_morphology0.56319429
86MP0005391_vision/eye_phenotype0.55769171
87MP0003195_calcinosis0.55695661
88MP0004215_abnormal_myocardial_fiber0.54461802
89MP0002837_dystrophic_cardiac_calcinosis0.53500709
90MP0000470_abnormal_stomach_morphology0.52630402
91MP0009115_abnormal_fat_cell0.52628527
92MP0002138_abnormal_hepatobiliary_system0.52037124
93MP0005083_abnormal_biliary_tract0.51402827
94MP0009046_muscle_twitch0.51203073
95MP0000427_abnormal_hair_cycle0.50841384
96MP0005636_abnormal_mineral_homeostasis0.50199760
97MP0000955_abnormal_spinal_cord0.48189449
98MP0008961_abnormal_basal_metabolism0.47689253
99MP0003283_abnormal_digestive_organ0.47448784
100MP0001849_ear_inflammation0.47348727

Predicted human phenotypes

RankGene SetZ-score
1Resting tremor (HP:0002322)6.33470369
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.13890595
3Absent/shortened dynein arms (HP:0200106)6.13890595
4Severe visual impairment (HP:0001141)5.53319721
5Abnormal ciliary motility (HP:0012262)5.33617233
6Abnormal respiratory motile cilium physiology (HP:0012261)5.26147811
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.02726507
8Abnormal respiratory motile cilium morphology (HP:0005938)4.59787928
9Abnormal respiratory epithelium morphology (HP:0012253)4.59787928
10Infertility (HP:0000789)4.38675983
11Postural instability (HP:0002172)4.24327012
12Attenuation of retinal blood vessels (HP:0007843)3.97241518
13Bony spicule pigmentary retinopathy (HP:0007737)3.93439442
14Tubulointerstitial nephritis (HP:0001970)3.92905736
15Abnormal rod and cone electroretinograms (HP:0008323)3.71458758
16Sex reversal (HP:0012245)3.63257974
17Abnormal sex determination (HP:0012244)3.63257974
18Sensory axonal neuropathy (HP:0003390)3.57541238
19Nasal polyposis (HP:0100582)3.53029048
20Abnormal pancreas size (HP:0012094)3.42217891
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.24039476
22Congenital sensorineural hearing impairment (HP:0008527)3.15822188
23Hypoplasia of the uterus (HP:0000013)3.13431655
24Azoospermia (HP:0000027)3.10348354
25Abnormality of macular pigmentation (HP:0008002)3.07372663
26Abnormality of the columella (HP:0009929)2.97772513
27Cerebellar dysplasia (HP:0007033)2.91476109
28Rhinitis (HP:0012384)2.89814209
29Abnormality of the nasal mucosa (HP:0000433)2.87303588
30Reduced antithrombin III activity (HP:0001976)2.84275078
31Asymmetric septal hypertrophy (HP:0001670)2.79341502
32Recurrent corneal erosions (HP:0000495)2.79055816
33Male pseudohermaphroditism (HP:0000037)2.76544089
34Hypoplastic ischia (HP:0003175)2.72643206
35Polydipsia (HP:0001959)2.66291130
36Abnormal drinking behavior (HP:0030082)2.66291130
37Bell-shaped thorax (HP:0001591)2.57058671
38Aplasia/hypoplasia of the uterus (HP:0008684)2.56131002
39Chronic hepatic failure (HP:0100626)2.55724127
40Male infertility (HP:0003251)2.54496266
41Abnormal spermatogenesis (HP:0008669)2.53631726
42Abnormality of the ischium (HP:0003174)2.48956948
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43343898
44Type II lissencephaly (HP:0007260)2.42173159
45Potter facies (HP:0002009)2.41516830
46Facial shape deformation (HP:0011334)2.41516830
47Abnormal urine output (HP:0012590)2.40318840
48Aplasia/Hypoplasia of the earlobes (HP:0009906)2.39955375
49Hyperkalemia (HP:0002153)2.35513810
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32452463
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32452463
52Colitis (HP:0002583)2.31081385
53Atonic seizures (HP:0010819)2.31079404
54Occipital encephalocele (HP:0002085)2.30081294
55Bronchiectasis (HP:0002110)2.29691670
56Renal dysplasia (HP:0000110)2.25225975
57Gonadal dysgenesis (HP:0000133)2.22359150
58Ventricular fibrillation (HP:0001663)2.20110177
59Polyuria (HP:0000103)2.19575144
60Inability to walk (HP:0002540)2.19101621
61Abnormality of renal excretion (HP:0011036)2.18725656
62Retinal dysplasia (HP:0007973)2.17253351
63Focal segmental glomerulosclerosis (HP:0000097)2.13038234
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.11034346
65Absent epiphyses (HP:0010577)2.11034346
66Median cleft lip (HP:0000161)2.10759007
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09768315
68Optic nerve hypoplasia (HP:0000609)2.06672294
69Thoracolumbar scoliosis (HP:0002944)2.04765359
70Flattened epiphyses (HP:0003071)2.03807389
71Progressive cerebellar ataxia (HP:0002073)2.01020238
72Abnormality of dental color (HP:0011073)2.00887175
73Unilateral renal agenesis (HP:0000122)1.97633362
74Thoracic kyphosis (HP:0002942)1.97025289
75Cone-rod dystrophy (HP:0000548)1.96840696
76Pancreatic fibrosis (HP:0100732)1.94057679
77Enlarged epiphyses (HP:0010580)1.92157803
78High pitched voice (HP:0001620)1.90097610
79Pili torti (HP:0003777)1.88035666
80Germ cell neoplasia (HP:0100728)1.87868020
81Chronic bronchitis (HP:0004469)1.87866694
82Retinal atrophy (HP:0001105)1.86485820
83Atrial fibrillation (HP:0005110)1.86261200
84Stage 5 chronic kidney disease (HP:0003774)1.85212738
85Abnormality of potassium homeostasis (HP:0011042)1.84854529
86Tetany (HP:0001281)1.83433397
87Hyperthyroidism (HP:0000836)1.83230596
88Glomerulosclerosis (HP:0000096)1.83158600
89Bulbous nose (HP:0000414)1.81423898
90Tubulointerstitial abnormality (HP:0001969)1.80527903
91Pancreatic cysts (HP:0001737)1.80495770
92Abnormality of the intrinsic pathway (HP:0010989)1.80464715
93Generalized aminoaciduria (HP:0002909)1.77403175
94Abnormality of the frontal sinuses (HP:0002687)1.76312150
95Calf muscle hypertrophy (HP:0008981)1.75875729
96Muscle hypertrophy of the lower extremities (HP:0008968)1.74767410
97Buphthalmos (HP:0000557)1.74365159
98Self-mutilation (HP:0000742)1.74190096
99Hyponatremia (HP:0002902)1.74063778
100True hermaphroditism (HP:0010459)1.71857190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK18.64430034
2PLK44.42940891
3MARK33.62222967
4PDK23.31863194
5MST1R3.03254714
6MAP4K22.73665354
7STK38L2.62765508
8STK382.60849443
9DDR22.59934563
10LATS12.55767643
11INSRR2.38504890
12FRK2.38353229
13MYLK2.30284283
14TESK12.27201374
15TLK12.02780449
16BRD41.98831915
17NEK21.95242593
18ZAK1.85471748
19BMPR1B1.83156299
20LATS21.79792229
21MAPK151.76423982
22NEK61.47485344
23TNIK1.36976777
24PTK2B1.29970967
25WNK11.27517948
26OBSCN1.26174383
27PLK21.25288426
28PDPK11.21873792
29CDK31.16883719
30RPS6KA51.15071635
31MET1.13043096
32MAP3K91.03742977
33PRKG20.98807592
34MAP2K70.98248276
35CDK120.98039243
36WNK40.96910290
37PDK10.94871069
38PRKD30.92708556
39PIK3CG0.82607754
40SGK4940.82022227
41SGK2230.82022227
42PNCK0.81143735
43STK390.81067700
44MST40.70971251
45MAP3K10.70320400
46PRKCQ0.68979464
47AKT30.65210502
48DYRK30.62752591
49ROCK10.61985730
50ACVR1B0.54754671
51CDK70.54249821
52KSR20.50053179
53PRKAA20.49286588
54MUSK0.44221993
55MAP3K20.42594085
56PRKG10.42249587
57FGFR20.40619452
58CAMK1G0.40599105
59CSNK1A1L0.39284041
60TGFBR10.38957150
61ADRBK20.38819943
62STK30.36872385
63MTOR0.36665911
64CAMK10.34978065
65NME20.34486338
66PBK0.33523199
67TIE10.31416365
68AKT20.30751279
69EGFR0.30511189
70PAK20.29776460
71RPS6KA10.26299437
72NTRK30.24531468
73ARAF0.23553760
74CDK80.23452863
75MELK0.23339334
76MAPK10.22517301
77CDC42BPA0.22119052
78RPS6KB10.21977432
79PRKCG0.21945410
80MAPK120.21111629
81NTRK20.20945245
82MAP3K80.20798229
83TRPM70.20421914
84MAPKAPK30.20095132
85CDK50.19493801
86SGK20.18359777
87CDK140.18086180
88EEF2K0.17980870
89CAMK2D0.17760587
90CCNB10.17523560
91EPHA20.15347072
92PAK10.15214913
93PLK10.14908112
94GRK10.14612553
95MOS0.14535412
96GSK3B0.14465187
97DYRK1B0.14176692
98BRSK20.14026987
99ATM0.13945367
100CDK10.13307340

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.57047190
2Olfactory transduction_Homo sapiens_hsa047404.21476561
3Butanoate metabolism_Homo sapiens_hsa006503.66383073
4Fatty acid biosynthesis_Homo sapiens_hsa000613.44415937
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.99606203
6Gap junction_Homo sapiens_hsa045402.57596962
7Nitrogen metabolism_Homo sapiens_hsa009102.49022573
8Hedgehog signaling pathway_Homo sapiens_hsa043402.44903066
9Arginine biosynthesis_Homo sapiens_hsa002202.34360691
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.18332574
11Propanoate metabolism_Homo sapiens_hsa006402.01456019
12Phenylalanine metabolism_Homo sapiens_hsa003602.00982042
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74275314
14Taste transduction_Homo sapiens_hsa047421.70612855
15beta-Alanine metabolism_Homo sapiens_hsa004101.54423633
16Fatty acid degradation_Homo sapiens_hsa000711.46633096
17Dorso-ventral axis formation_Homo sapiens_hsa043201.41383975
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.37268358
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.28134072
20Chemical carcinogenesis_Homo sapiens_hsa052041.21757125
21Phagosome_Homo sapiens_hsa041451.18999049
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18732721
23Tryptophan metabolism_Homo sapiens_hsa003801.17417422
24Arginine and proline metabolism_Homo sapiens_hsa003301.16233418
25Fatty acid metabolism_Homo sapiens_hsa012121.15739218
26Renin secretion_Homo sapiens_hsa049241.15495452
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14883894
28Circadian rhythm_Homo sapiens_hsa047101.14742438
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11150764
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.10569925
31Pyruvate metabolism_Homo sapiens_hsa006201.10315400
32Selenocompound metabolism_Homo sapiens_hsa004501.10018182
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07999139
34Oocyte meiosis_Homo sapiens_hsa041141.07817828
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05178797
36Salivary secretion_Homo sapiens_hsa049701.05037790
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03793753
38Tyrosine metabolism_Homo sapiens_hsa003501.03477568
39Purine metabolism_Homo sapiens_hsa002301.02446955
40Insulin secretion_Homo sapiens_hsa049111.01908192
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01003444
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96309171
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.93811278
44PPAR signaling pathway_Homo sapiens_hsa033200.93282293
45Calcium signaling pathway_Homo sapiens_hsa040200.90175604
46Regulation of autophagy_Homo sapiens_hsa041400.89059772
47Glutathione metabolism_Homo sapiens_hsa004800.85545603
48Apoptosis_Homo sapiens_hsa042100.84375387
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84235858
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82193710
51Alcoholism_Homo sapiens_hsa050340.82031288
52Gastric acid secretion_Homo sapiens_hsa049710.81880046
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81275360
54Systemic lupus erythematosus_Homo sapiens_hsa053220.80146537
55Retinol metabolism_Homo sapiens_hsa008300.79234521
56Circadian entrainment_Homo sapiens_hsa047130.77636062
57Basal transcription factors_Homo sapiens_hsa030220.77389584
58ABC transporters_Homo sapiens_hsa020100.73551884
59Type II diabetes mellitus_Homo sapiens_hsa049300.72738734
60Bile secretion_Homo sapiens_hsa049760.68518804
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67524878
62RNA transport_Homo sapiens_hsa030130.67457412
63Oxytocin signaling pathway_Homo sapiens_hsa049210.64277790
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62947147
65Glucagon signaling pathway_Homo sapiens_hsa049220.61650417
66Sulfur relay system_Homo sapiens_hsa041220.59216158
67Histidine metabolism_Homo sapiens_hsa003400.58952837
68Phototransduction_Homo sapiens_hsa047440.57101522
69cAMP signaling pathway_Homo sapiens_hsa040240.56219170
70Estrogen signaling pathway_Homo sapiens_hsa049150.54667870
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54616137
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52063437
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51944530
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49250220
75Renin-angiotensin system_Homo sapiens_hsa046140.47871777
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47010002
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46539119
78Peroxisome_Homo sapiens_hsa041460.45642745
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43903866
80Type I diabetes mellitus_Homo sapiens_hsa049400.43541772
81Mineral absorption_Homo sapiens_hsa049780.41003615
82mRNA surveillance pathway_Homo sapiens_hsa030150.38106601
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37963040
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.37122255
85Morphine addiction_Homo sapiens_hsa050320.36441329
86Protein digestion and absorption_Homo sapiens_hsa049740.35871981
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35190394
88Metabolic pathways_Homo sapiens_hsa011000.35080125
89Sphingolipid metabolism_Homo sapiens_hsa006000.34761522
90Antigen processing and presentation_Homo sapiens_hsa046120.33713284
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33621768
92Glutamatergic synapse_Homo sapiens_hsa047240.30186886
93Tight junction_Homo sapiens_hsa045300.30151783
94Fanconi anemia pathway_Homo sapiens_hsa034600.29557307
95Cardiac muscle contraction_Homo sapiens_hsa042600.28977523
96GABAergic synapse_Homo sapiens_hsa047270.28193805
97Complement and coagulation cascades_Homo sapiens_hsa046100.26268283
98Glycerolipid metabolism_Homo sapiens_hsa005610.25175582
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23508732
100Autoimmune thyroid disease_Homo sapiens_hsa053200.22369103

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