ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	drug catabolic process (GO:0042737)	6.92373655
2	L-phenylalanine catabolic process (GO:0006559)	6.74133773
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.74133773
4	* regulation of protein activation cascade (GO:2000257)	6.58386482
5	exogenous drug catabolic process (GO:0042738)	6.47809734
6	glyoxylate metabolic process (GO:0046487)	6.39356139
7	complement activation, alternative pathway (GO:0006957)	6.23104863
8	* regulation of complement activation (GO:0030449)	6.21768111
9	regulation of fibrinolysis (GO:0051917)	6.08464460
10	L-phenylalanine metabolic process (GO:0006558)	6.03627771
11	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.03627771
12	aromatic amino acid family catabolic process (GO:0009074)	5.97479189
13	epoxygenase P450 pathway (GO:0019373)	5.89323695
14	negative regulation of fibrinolysis (GO:0051918)	5.70766611
15	oxidative demethylation (GO:0070989)	5.47998796
16	omega-hydroxylase P450 pathway (GO:0097267)	5.44965152
17	urea metabolic process (GO:0019627)	5.29958972
18	indole-containing compound catabolic process (GO:0042436)	5.29341781
19	indolalkylamine catabolic process (GO:0046218)	5.29341781
20	tryptophan catabolic process (GO:0006569)	5.29341781
21	peptidyl-glutamic acid carboxylation (GO:0017187)	5.08571843
22	protein carboxylation (GO:0018214)	5.08571843
23	cellular ketone body metabolic process (GO:0046950)	5.01401570
24	blood coagulation, intrinsic pathway (GO:0007597)	4.84717075
25	nitrogen cycle metabolic process (GO:0071941)	4.75932946
26	drug metabolic process (GO:0017144)	4.75825459
27	* negative regulation of protein activation cascade (GO:2000258)	4.72432798
28	urea cycle (GO:0000050)	4.71837626
29	regulation of triglyceride catabolic process (GO:0010896)	4.71610677
30	serine family amino acid catabolic process (GO:0009071)	4.69958404
31	bile acid biosynthetic process (GO:0006699)	4.69530351
32	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.57192717
33	cellular glucuronidation (GO:0052695)	4.54557163
34	aromatic amino acid family metabolic process (GO:0009072)	4.49791980
35	ketone body metabolic process (GO:1902224)	4.44106987
36	flavonoid metabolic process (GO:0009812)	4.42668607
37	tryptophan metabolic process (GO:0006568)	4.42516649
38	high-density lipoprotein particle remodeling (GO:0034375)	4.30305708
39	kynurenine metabolic process (GO:0070189)	4.30104951
40	fibrinolysis (GO:0042730)	4.27793109
41	phenylpropanoid metabolic process (GO:0009698)	4.27568661
42	uronic acid metabolic process (GO:0006063)	4.27547748
43	glucuronate metabolic process (GO:0019585)	4.27547748
44	tyrosine metabolic process (GO:0006570)	4.27329190
45	bile acid metabolic process (GO:0008206)	4.24103300
46	S-adenosylmethionine metabolic process (GO:0046500)	4.23790134
47	plasma lipoprotein particle remodeling (GO:0034369)	4.21383468
48	protein-lipid complex remodeling (GO:0034368)	4.21383468
49	macromolecular complex remodeling (GO:0034367)	4.21383468
50	indolalkylamine metabolic process (GO:0006586)	4.18872049
51	ethanol oxidation (GO:0006069)	4.11386810
52	triglyceride homeostasis (GO:0070328)	4.10706791
53	acylglycerol homeostasis (GO:0055090)	4.10706791
54	imidazole-containing compound metabolic process (GO:0052803)	4.10672229
55	* negative regulation of complement activation (GO:0045916)	4.08357082
56	negative regulation of cholesterol transport (GO:0032375)	4.03366642
57	negative regulation of sterol transport (GO:0032372)	4.03366642
58	* protein activation cascade (GO:0072376)	4.01016074
59	intestinal cholesterol absorption (GO:0030299)	4.00361961
60	glycine metabolic process (GO:0006544)	3.99426839
61	alkaloid metabolic process (GO:0009820)	3.96976342
62	reverse cholesterol transport (GO:0043691)	3.93510150
63	arginine metabolic process (GO:0006525)	3.85699379
64	bile acid and bile salt transport (GO:0015721)	3.83691977
65	alpha-amino acid catabolic process (GO:1901606)	3.81508555
66	regulation of plasminogen activation (GO:0010755)	3.81226299
67	cholesterol efflux (GO:0033344)	3.78479626
68	* regulation of humoral immune response (GO:0002920)	3.64466012
69	heme transport (GO:0015886)	3.64014397
70	acute-phase response (GO:0006953)	3.59546866
71	* complement activation, classical pathway (GO:0006958)	3.59091073
72	* complement activation (GO:0006956)	3.56118539
73	amino-acid betaine metabolic process (GO:0006577)	3.53815450
74	drug transmembrane transport (GO:0006855)	3.50002297
75	amine catabolic process (GO:0009310)	3.46069149
76	cellular biogenic amine catabolic process (GO:0042402)	3.46069149
77	cytolysis (GO:0019835)	3.44692475
78	benzene-containing compound metabolic process (GO:0042537)	3.43233870
79	negative regulation of hemostasis (GO:1900047)	3.41441405
80	negative regulation of blood coagulation (GO:0030195)	3.41441405
81	cellular amino acid catabolic process (GO:0009063)	3.38404039
82	serine family amino acid metabolic process (GO:0009069)	3.38018248
83	negative regulation of lipase activity (GO:0060192)	3.35915352
84	L-methionine salvage (GO:0071267)	3.33874699
85	L-methionine biosynthetic process (GO:0071265)	3.33874699
86	amino acid salvage (GO:0043102)	3.33874699
87	cysteine metabolic process (GO:0006534)	3.31146783
88	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.28993848
89	very-low-density lipoprotein particle assembly (GO:0034379)	3.26159967
90	regulation of cholesterol esterification (GO:0010872)	3.26030699
91	ethanol metabolic process (GO:0006067)	3.25394953
92	xenobiotic catabolic process (GO:0042178)	3.24412826
93	sodium-independent organic anion transport (GO:0043252)	3.21532770
94	phospholipid efflux (GO:0033700)	3.19640138
95	plasma lipoprotein particle organization (GO:0071827)	3.14485998
96	homocysteine metabolic process (GO:0050667)	3.10663140
97	peptidyl-glutamic acid modification (GO:0018200)	3.09253278
98	negative regulation of coagulation (GO:0050819)	3.08252767
99	regulation of lipoprotein particle clearance (GO:0010984)	3.07631465
100	low-density lipoprotein particle remodeling (GO:0034374)	3.05602725

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.57770073
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.35435813
3	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.84773225
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.81935123
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.80330369
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.78570981
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.73272326
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57047861
9	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.47322460
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44528192
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40023575
12	VDR_22108803_ChIP-Seq_LS180_Human	2.37372320
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32347049
14	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.28962750
15	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.25090387
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22275729
17	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.97574936
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.92271884
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90358809
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90013220
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.88138575
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86807113
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.75888718
24	STAT3_23295773_ChIP-Seq_U87_Human	1.75406465
25	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.68954035
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68478145
27	P300_19829295_ChIP-Seq_ESCs_Human	1.67816097
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.66456572
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66073730
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.65510266
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62972178
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.62890227
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62222771
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59735564
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.59230364
36	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.58061644
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.57424045
38	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.57130148
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56590991
40	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.53875409
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.52942080
42	FUS_26573619_Chip-Seq_HEK293_Human	1.52075335
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48800683
44	TCF4_23295773_ChIP-Seq_U87_Human	1.47472267
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46921495
46	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.38970805
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.38884756
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38884756
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37406194
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.36816615
51	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36652299
52	EWS_26573619_Chip-Seq_HEK293_Human	1.32139301
53	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.32107533
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28714913
55	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.28123742
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27936079
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27633385
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27633385
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25995660
60	AR_20517297_ChIP-Seq_VCAP_Human	1.23022708
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22298504
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.21031193
63	* HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.20990072
64	AR_25329375_ChIP-Seq_VCAP_Human	1.20930434
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20665936
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16932028
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16722941
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15885180
69	TP53_16413492_ChIP-PET_HCT116_Human	1.15126801
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14653609
71	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14561812
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14373049
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.13890672
74	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.13745022
75	AR_21572438_ChIP-Seq_LNCaP_Human	1.12596796
76	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.12483480
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12127435
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11836412
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10794686
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09165897
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09156565
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08193230
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08193230
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06977929
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05938016
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05700531
87	ETV1_20927104_ChIP-Seq_GIST48_Human	1.05678800
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05534253
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05436663
90	TP53_22573176_ChIP-Seq_HFKS_Human	1.04802770
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04322352
92	AHR_22903824_ChIP-Seq_MCF-7_Human	1.03516279
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03369074
94	PHF8_20622853_ChIP-Seq_HELA_Human	1.03219096
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02409420
96	* TCF4_18268006_ChIP-ChIP_LS174T_Human	1.01619967
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.01447549
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99934297
99	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99436697
100	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98367074

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.68677618
2	MP0003195_calcinosis	6.24632217
3	MP0005085_abnormal_gallbladder_physiolo	5.98532610
4	MP0005360_urolithiasis	5.07466241
5	MP0008875_abnormal_xenobiotic_pharmacok	4.99365602
6	MP0005365_abnormal_bile_salt	4.85698659
7	MP0002138_abnormal_hepatobiliary_system	3.78872650
8	MP0003252_abnormal_bile_duct	3.67672007
9	MP0003868_abnormal_feces_composition	2.93766889
10	MP0010329_abnormal_lipoprotein_level	2.88791419
11	MP0002876_abnormal_thyroid_physiology	2.77743832
12	MP0001666_abnormal_nutrient_absorption	2.72825780
13	MP0009697_abnormal_copulation	2.54295590
14	MP0005332_abnormal_amino_acid	2.36823272
15	MP0001764_abnormal_homeostasis	1.97260697
16	MP0005083_abnormal_biliary_tract	1.77506149
17	MP0005551_abnormal_eye_electrophysiolog	1.75952635
18	MP0000569_abnormal_digit_pigmentation	1.75710200
19	MP0002118_abnormal_lipid_homeostasis	1.55424385
20	MP0000609_abnormal_liver_physiology	1.50425553
21	MP0008872_abnormal_physiological_respon	1.40627123
22	MP0005408_hypopigmentation	1.30691873
23	MP0003950_abnormal_plasma_membrane	1.29556305
24	MP0005670_abnormal_white_adipose	1.28863466
25	MP0003806_abnormal_nucleotide_metabolis	1.25699380
26	MP0003646_muscle_fatigue	1.22811989
27	MP0008057_abnormal_DNA_replication	1.22683282
28	MP0005645_abnormal_hypothalamus_physiol	1.20070146
29	MP0005395_other_phenotype	1.14107794
30	MP0004043_abnormal_pH_regulation	1.13144778
31	MP0001661_extended_life_span	1.12260412
32	MP0001501_abnormal_sleep_pattern	1.10704559
33	MP0004019_abnormal_vitamin_homeostasis	1.10168749
34	MP0002168_other_aberrant_phenotype	1.07206514
35	MP0005319_abnormal_enzyme/_coenzyme	1.04343490
36	MP0003718_maternal_effect	1.04119421
37	MP0005646_abnormal_pituitary_gland	1.01890431
38	MP0003879_abnormal_hair_cell	1.01806734
39	MP0009643_abnormal_urine_homeostasis	0.96962462
40	MP0005167_abnormal_blood-brain_barrier	0.95251190
41	MP0005266_abnormal_metabolism	0.91516278
42	MP0009840_abnormal_foam_cell	0.91143717
43	MP0005376_homeostasis/metabolism_phenot	0.90611663
44	MP0000598_abnormal_liver_morphology	0.89745375
45	MP0005410_abnormal_fertilization	0.89272997
46	MP0009046_muscle_twitch	0.88109552
47	MP0005584_abnormal_enzyme/coenzyme_acti	0.86078795
48	MP0009642_abnormal_blood_homeostasis	0.82712482
49	MP0000427_abnormal_hair_cycle	0.82515615
50	MP0005636_abnormal_mineral_homeostasis	0.79429422
51	MP0005253_abnormal_eye_physiology	0.78756010
52	MP0002928_abnormal_bile_duct	0.78294132
53	MP0003656_abnormal_erythrocyte_physiolo	0.77577222
54	MP0010368_abnormal_lymphatic_system	0.76532045
55	MP0004142_abnormal_muscle_tone	0.76261287
56	MP0001986_abnormal_taste_sensitivity	0.75470998
57	MP0002078_abnormal_glucose_homeostasis	0.75468133
58	MP0002971_abnormal_brown_adipose	0.74938327
59	MP0004147_increased_porphyrin_level	0.74438261
60	MP0002938_white_spotting	0.74371606
61	MP0005220_abnormal_exocrine_pancreas	0.72111872
62	MP0005448_abnormal_energy_balance	0.71260264
63	MP0009764_decreased_sensitivity_to	0.71104269
64	MP0005187_abnormal_penis_morphology	0.69687296
65	MP0005647_abnormal_sex_gland	0.69394251
66	MP0001968_abnormal_touch/_nociception	0.65415708
67	MP0002837_dystrophic_cardiac_calcinosis	0.65088982
68	MP0009745_abnormal_behavioral_response	0.63682803
69	MP0006292_abnormal_olfactory_placode	0.63032749
70	MP0002102_abnormal_ear_morphology	0.62926616
71	MP0003953_abnormal_hormone_level	0.62288438
72	MP0010386_abnormal_urinary_bladder	0.61910885
73	MP0000371_diluted_coat_color	0.60593075
74	MP0002132_abnormal_respiratory_system	0.60381963
75	MP0008775_abnormal_heart_ventricle	0.60364752
76	MP0005334_abnormal_fat_pad	0.58090856
77	MP0001324_abnormal_eye_pigmentation	0.56923594
78	MP0000372_irregular_coat_pigmentation	0.56042601
79	MP0003122_maternal_imprinting	0.55657995
80	MP0000383_abnormal_hair_follicle	0.54861656
81	MP0003011_delayed_dark_adaptation	0.54549768
82	MP0004130_abnormal_muscle_cell	0.54467300
83	MP0003186_abnormal_redox_activity	0.54387497
84	MP0005195_abnormal_posterior_eye	0.52910233
85	MP0003638_abnormal_response/metabolism_	0.51530880
86	MP0005084_abnormal_gallbladder_morpholo	0.50799681
87	MP0001756_abnormal_urination	0.50365443
88	MP0003698_abnormal_male_reproductive	0.50156977
89	MP0002160_abnormal_reproductive_system	0.49444052
90	MP0002736_abnormal_nociception_after	0.49128152
91	MP0002090_abnormal_vision	0.49120223
92	MP0009115_abnormal_fat_cell	0.48921885
93	MP0008058_abnormal_DNA_repair	0.47953526
94	MP0003633_abnormal_nervous_system	0.47668071
95	MP0006054_spinal_hemorrhage	0.46991338
96	MP0000013_abnormal_adipose_tissue	0.46592863
97	MP0003045_fibrosis	0.46053107
98	MP0005386_behavior/neurological_phenoty	0.45070099
99	MP0004924_abnormal_behavior	0.45070099
100	MP0002638_abnormal_pupillary_reflex	0.44957845

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	7.48129942
2	Deep venous thrombosis (HP:0002625)	7.08890820
3	Hypobetalipoproteinemia (HP:0003563)	6.69120985
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.56808324
5	Complement deficiency (HP:0004431)	6.19356379
6	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.88472035
7	Conjugated hyperbilirubinemia (HP:0002908)	4.59072370
8	Joint hemorrhage (HP:0005261)	4.58847977
9	Abnormality of complement system (HP:0005339)	4.45708479
10	Fair hair (HP:0002286)	4.17011322
11	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.99531755
12	Abnormality of pyrimidine metabolism (HP:0004353)	3.96133581
13	Hyperlipoproteinemia (HP:0010980)	3.85114214
14	Abnormality of the common coagulation pathway (HP:0010990)	3.66447596
15	Glomerulonephritis (HP:0000099)	3.62024109
16	Hypolipoproteinemia (HP:0010981)	3.61059221
17	Intrahepatic cholestasis (HP:0001406)	3.58669356
18	Spontaneous abortion (HP:0005268)	3.54446632
19	Xanthomatosis (HP:0000991)	3.47880643
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.27624949
21	Abnormality of alanine metabolism (HP:0010916)	3.27624949
22	Hyperalaninemia (HP:0003348)	3.27624949
23	Abnormality of the intrinsic pathway (HP:0010989)	3.14953642
24	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.10478792
25	Systemic lupus erythematosus (HP:0002725)	3.04033837
26	Hyperventilation (HP:0002883)	3.02966740
27	Generalized hypopigmentation of hair (HP:0011358)	3.00485940
28	Hyperglycinemia (HP:0002154)	2.95905558
29	Epidermoid cyst (HP:0200040)	2.94620728
30	Cerebellar dysplasia (HP:0007033)	2.87996116
31	Abnormality of serum amino acid levels (HP:0003112)	2.79787147
32	Hyperammonemia (HP:0001987)	2.76884513
33	Ketosis (HP:0001946)	2.76319657
34	Abnormality of glycine metabolism (HP:0010895)	2.71233782
35	Abnormality of serine family amino acid metabolism (HP:0010894)	2.71233782
36	Hyperglycinuria (HP:0003108)	2.70029892
37	Alkalosis (HP:0001948)	2.64173615
38	Abnormality of the renal cortex (HP:0011035)	2.58711390
39	Bile duct proliferation (HP:0001408)	2.58345193
40	Abnormal biliary tract physiology (HP:0012439)	2.58345193
41	Generalized aminoaciduria (HP:0002909)	2.57374135
42	Retinal atrophy (HP:0001105)	2.56714635
43	Reduced antithrombin III activity (HP:0001976)	2.56624420
44	Nephritis (HP:0000123)	2.54772219
45	Ketoacidosis (HP:0001993)	2.51514963
46	Arthropathy (HP:0003040)	2.51471378
47	Vascular calcification (HP:0004934)	2.47088500
48	Abnormality of methionine metabolism (HP:0010901)	2.46845193
49	Pancreatic cysts (HP:0001737)	2.46279918
50	Renal cortical cysts (HP:0000803)	2.42785452
51	Submucous cleft hard palate (HP:0000176)	2.42424614
52	Enlarged kidneys (HP:0000105)	2.39854001
53	Chronic hepatic failure (HP:0100626)	2.22661355
54	Hypothermia (HP:0002045)	2.19977410
55	Fat malabsorption (HP:0002630)	2.19884143
56	Attenuation of retinal blood vessels (HP:0007843)	2.19358667
57	Gaze-evoked nystagmus (HP:0000640)	2.17644206
58	Hypoalphalipoproteinemia (HP:0003233)	2.17079209
59	Blue irides (HP:0000635)	2.13512655
60	Abnormality of the nasal septum (HP:0000419)	2.13476121
61	Delayed CNS myelination (HP:0002188)	2.10791886
62	Congenital stationary night blindness (HP:0007642)	2.10401140
63	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.06701013
64	Metabolic acidosis (HP:0001942)	2.06313353
65	Abnormality of proline metabolism (HP:0010907)	2.05180038
66	Hydroxyprolinuria (HP:0003080)	2.05180038
67	Cardiovascular calcification (HP:0011915)	2.04906499
68	Gingival bleeding (HP:0000225)	2.03059184
69	Recurrent gram-negative bacterial infections (HP:0005420)	2.01849963
70	Menorrhagia (HP:0000132)	2.01454641
71	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.98132872
72	Proximal tubulopathy (HP:0000114)	1.97610329
73	True hermaphroditism (HP:0010459)	1.96849757
74	Pancreatic fibrosis (HP:0100732)	1.96168170
75	Genetic anticipation (HP:0003743)	1.92747547
76	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90728714
77	Mitral stenosis (HP:0001718)	1.89740343
78	Type II lissencephaly (HP:0007260)	1.88094022
79	Lethargy (HP:0001254)	1.88058625
80	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.87774166
81	Hypercholesterolemia (HP:0003124)	1.87366237
82	Abnormality of nucleobase metabolism (HP:0010932)	1.85591703
83	Cerebral edema (HP:0002181)	1.82829250
84	Facial shape deformation (HP:0011334)	1.82648621
85	Potter facies (HP:0002009)	1.82648621
86	Hepatocellular carcinoma (HP:0001402)	1.77882943
87	Abolished electroretinogram (ERG) (HP:0000550)	1.76725337
88	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.75492039
89	Decreased central vision (HP:0007663)	1.71953718
90	Molar tooth sign on MRI (HP:0002419)	1.71057219
91	Abnormality of midbrain morphology (HP:0002418)	1.71057219
92	Glycosuria (HP:0003076)	1.68860310
93	Abnormality of urine glucose concentration (HP:0011016)	1.68860310
94	Opisthotonus (HP:0002179)	1.68439420
95	Osteomalacia (HP:0002749)	1.68215848
96	Increased corneal curvature (HP:0100692)	1.66185681
97	Keratoconus (HP:0000563)	1.66185681
98	Inability to walk (HP:0002540)	1.65646525
99	Tubular atrophy (HP:0000092)	1.64082891
100	Cystic liver disease (HP:0006706)	1.61822542

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.48694769
2	PDK2	4.54923711
3	ACVR1B	3.42492624
4	WNK4	2.96491242
5	BMPR1B	2.79337371
6	STK39	2.43564103
7	ADRBK2	2.36373800
8	INSRR	2.33803309
9	MAP4K2	2.20828218
10	ZAK	2.08364044
11	OXSR1	2.05422206
12	AKT3	1.93950789
13	PIK3CG	1.81947358
14	WNK3	1.63253034
15	TAOK3	1.62933699
16	STK38L	1.44373576
17	MST1R	1.43148922
18	GRK1	1.43048299
19	BRSK2	1.32256101
20	NUAK1	1.27237605
21	TLK1	1.21278836
22	PRKAA2	1.21176301
23	MAPK13	1.17746464
24	LATS1	1.17695910
25	CAMKK2	1.13781327
26	PINK1	1.12902276
27	PIK3CA	1.12327360
28	CASK	1.04571759
29	FER	1.03092171
30	PBK	1.01374783
31	ADRBK1	0.95547657
32	MAPKAPK3	0.94952587
33	MAP3K4	0.91876766
34	PRKCG	0.90377009
35	NTRK3	0.89925743
36	FGFR3	0.89884624
37	MAPK11	0.88920598
38	MAP2K6	0.82377370
39	PRKCE	0.79539633
40	MKNK2	0.78199002
41	MET	0.76977723
42	NEK6	0.76544807
43	EIF2AK3	0.75438151
44	PRKAA1	0.70285284
45	NEK1	0.70164634
46	NLK	0.70028097
47	TXK	0.61024311
48	STK3	0.60043122
49	MAP3K7	0.59541261
50	PRKACG	0.59502987
51	EPHA3	0.57535207
52	CSNK1G1	0.56203124
53	PAK3	0.55674991
54	MAPKAPK5	0.55509347
55	ERBB3	0.54259361
56	FGFR2	0.53740906
57	BCKDK	0.52480016
58	DAPK2	0.52227720
59	IRAK1	0.52041636
60	BCR	0.51153537
61	PRKACA	0.50950853
62	ERBB2	0.49982734
63	CSNK1A1L	0.49928327
64	CSNK1D	0.49267769
65	PDK1	0.46713931
66	PRKACB	0.45433943
67	MUSK	0.43037034
68	TEC	0.43034031
69	SIK2	0.42922175
70	MKNK1	0.41649097
71	TGFBR1	0.40883380
72	MARK1	0.40648447
73	FGFR4	0.40377668
74	STK38	0.39882621
75	IGF1R	0.39736223
76	MAP2K1	0.39632165
77	NEK2	0.38954572
78	SGK2	0.36450698
79	PRKCA	0.35549721
80	TNK2	0.35367052
81	CAMK1G	0.34584562
82	STK11	0.34292679
83	FLT3	0.34096100
84	SGK1	0.33869028
85	IKBKB	0.33794462
86	CAMK1D	0.33207725
87	BRD4	0.33127231
88	PRKG1	0.32631715
89	TRIM28	0.32127315
90	PDPK1	0.31703594
91	OBSCN	0.31600039
92	EPHA4	0.31349649
93	NME1	0.30864244
94	MELK	0.30753469
95	ATR	0.30221169
96	CSNK1E	0.30191940
97	CHUK	0.30031867
98	CAMK2A	0.30013001
99	PRKCB	0.29807069
100	MAP2K7	0.29704124

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Complement and coagulation cascades_Homo sapiens_hsa04610	3.67828820
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.60717927
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.20479202
4	Caffeine metabolism_Homo sapiens_hsa00232	3.14639578
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.12534078
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.11792588
7	Retinol metabolism_Homo sapiens_hsa00830	2.93929927
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.67577333
9	Butanoate metabolism_Homo sapiens_hsa00650	2.64585296
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.63978689
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.62436001
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.53127138
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.48115948
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.30365549
15	Tryptophan metabolism_Homo sapiens_hsa00380	2.25621366
16	Fatty acid degradation_Homo sapiens_hsa00071	2.24754908
17	Linoleic acid metabolism_Homo sapiens_hsa00591	2.12209497
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04633877
19	Histidine metabolism_Homo sapiens_hsa00340	1.99217061
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98745010
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.91347066
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.87537738
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.86163249
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.79816518
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.77190938
26	Tyrosine metabolism_Homo sapiens_hsa00350	1.71521014
27	ABC transporters_Homo sapiens_hsa02010	1.64771118
28	Bile secretion_Homo sapiens_hsa04976	1.57374203
29	Peroxisome_Homo sapiens_hsa04146	1.52319451
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.48384704
31	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.44037471
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.42312491
33	Propanoate metabolism_Homo sapiens_hsa00640	1.41939924
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.33050496
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30119904
36	PPAR signaling pathway_Homo sapiens_hsa03320	1.29205183
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29107830
38	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.27876657
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19573477
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.14061239
41	One carbon pool by folate_Homo sapiens_hsa00670	1.12074684
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09799893
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.07552294
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04195236
45	Fatty acid metabolism_Homo sapiens_hsa01212	1.02287104
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95237170
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.94831730
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.90943000
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.90136863
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88899707
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.88318129
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.78812987
53	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.78613791
54	Lysine degradation_Homo sapiens_hsa00310	0.75819197
55	Sulfur metabolism_Homo sapiens_hsa00920	0.73426870
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69461752
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.68211068
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59812753
59	Metabolic pathways_Homo sapiens_hsa01100	0.58832956
60	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54945473
61	Sulfur relay system_Homo sapiens_hsa04122	0.54777889
62	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.50404890
63	Phototransduction_Homo sapiens_hsa04744	0.50035042
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.45252382
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.42371694
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.40848449
67	Carbon metabolism_Homo sapiens_hsa01200	0.40778440
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38327597
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.37417571
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35223515
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.33105187
72	Homologous recombination_Homo sapiens_hsa03440	0.28904005
73	Circadian rhythm_Homo sapiens_hsa04710	0.27725320
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27550209
75	Mineral absorption_Homo sapiens_hsa04978	0.27494628
76	Serotonergic synapse_Homo sapiens_hsa04726	0.27368411
77	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.23019896
78	Insulin resistance_Homo sapiens_hsa04931	0.22936097
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.22660414
80	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.22414172
81	Fanconi anemia pathway_Homo sapiens_hsa03460	0.21950641
82	Nicotine addiction_Homo sapiens_hsa05033	0.18644319
83	Prion diseases_Homo sapiens_hsa05020	0.18539801
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.15883581
85	Taste transduction_Homo sapiens_hsa04742	0.15612896
86	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.13755545
87	Morphine addiction_Homo sapiens_hsa05032	0.12768138
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.11298382
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.10034337
90	Fatty acid elongation_Homo sapiens_hsa00062	0.09934493
91	Glutathione metabolism_Homo sapiens_hsa00480	0.09412360
92	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.09205360
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.07995868
94	Renin-angiotensin system_Homo sapiens_hsa04614	0.07111443
95	GABAergic synapse_Homo sapiens_hsa04727	0.06264424
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.06043508
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.05618582
98	Purine metabolism_Homo sapiens_hsa00230	0.03970835
99	Olfactory transduction_Homo sapiens_hsa04740	0.03491390
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.02616177

C4BPB

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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