ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of protein activation cascade (GO:2000257)	8.39925376
2	regulation of complement activation (GO:0030449)	8.20224455
3	negative regulation of fibrinolysis (GO:0051918)	8.12551243
4	regulation of fibrinolysis (GO:0051917)	7.77649226
5	complement activation, alternative pathway (GO:0006957)	7.59778116
6	exogenous drug catabolic process (GO:0042738)	7.27423925
7	L-phenylalanine catabolic process (GO:0006559)	7.14993845
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.14993845
9	peptidyl-glutamic acid carboxylation (GO:0017187)	6.88398862
10	protein carboxylation (GO:0018214)	6.88398862
11	L-phenylalanine metabolic process (GO:0006558)	6.64013504
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.64013504
13	epoxygenase P450 pathway (GO:0019373)	6.53141873
14	regulation of apoptotic cell clearance (GO:2000425)	6.42769178
15	drug catabolic process (GO:0042737)	6.36542004
16	omega-hydroxylase P450 pathway (GO:0097267)	6.20989244
17	blood coagulation, intrinsic pathway (GO:0007597)	5.97557634
18	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.73546415
19	very-low-density lipoprotein particle assembly (GO:0034379)	5.56239251
20	intestinal cholesterol absorption (GO:0030299)	5.54528615
21	regulation of plasminogen activation (GO:0010755)	5.43064206
22	plasma lipoprotein particle remodeling (GO:0034369)	5.34392768
23	protein-lipid complex remodeling (GO:0034368)	5.34392768
24	macromolecular complex remodeling (GO:0034367)	5.34392768
25	complement activation, classical pathway (GO:0006958)	5.34247405
26	protein activation cascade (GO:0072376)	5.21825648
27	negative regulation of protein activation cascade (GO:2000258)	5.20372551
28	plasma lipoprotein particle assembly (GO:0034377)	5.12332631
29	fibrinolysis (GO:0042730)	5.09903219
30	low-density lipoprotein particle remodeling (GO:0034374)	5.06266963
31	cholesterol efflux (GO:0033344)	4.97282938
32	regulation of humoral immune response (GO:0002920)	4.90119305
33	negative regulation of sterol transport (GO:0032372)	4.85222613
34	negative regulation of cholesterol transport (GO:0032375)	4.85222613
35	complement activation (GO:0006956)	4.81137697
36	regulation of cholesterol esterification (GO:0010872)	4.80173656
37	high-density lipoprotein particle remodeling (GO:0034375)	4.63502192
38	urea metabolic process (GO:0019627)	4.62516422
39	plasma lipoprotein particle organization (GO:0071827)	4.62365050
40	acute-phase response (GO:0006953)	4.62314552
41	aromatic amino acid family catabolic process (GO:0009074)	4.61350225
42	opsonization (GO:0008228)	4.60365781
43	protein-lipid complex assembly (GO:0065005)	4.58285291
44	positive regulation of lipoprotein lipase activity (GO:0051006)	4.53263022
45	positive regulation of triglyceride lipase activity (GO:0061365)	4.53263022
46	ethanol oxidation (GO:0006069)	4.43318447
47	protein-lipid complex subunit organization (GO:0071825)	4.35913021
48	reverse cholesterol transport (GO:0043691)	4.32500618
49	negative regulation of complement activation (GO:0045916)	4.29177510
50	negative regulation of hemostasis (GO:1900047)	4.28302536
51	negative regulation of blood coagulation (GO:0030195)	4.28302536
52	glutamate metabolic process (GO:0006536)	4.25004686
53	glyoxylate metabolic process (GO:0046487)	4.17852580
54	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.16692619
55	nitrogen cycle metabolic process (GO:0071941)	4.15882290
56	drug metabolic process (GO:0017144)	4.06995264
57	urea cycle (GO:0000050)	4.03139147
58	tyrosine metabolic process (GO:0006570)	4.02365893
59	positive regulation of blood coagulation (GO:0030194)	3.98006863
60	positive regulation of hemostasis (GO:1900048)	3.98006863
61	acylglycerol homeostasis (GO:0055090)	3.97491358
62	triglyceride homeostasis (GO:0070328)	3.97491358
63	bile acid metabolic process (GO:0008206)	3.96891271
64	bile acid biosynthetic process (GO:0006699)	3.95699469
65	plasma lipoprotein particle clearance (GO:0034381)	3.94746356
66	negative regulation of coagulation (GO:0050819)	3.91399746
67	cellular glucuronidation (GO:0052695)	3.90475593
68	phospholipid efflux (GO:0033700)	3.89962353
69	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.86929473
70	cytolysis (GO:0019835)	3.84290912
71	regulation of cholesterol biosynthetic process (GO:0045540)	3.84149103
72	lipoprotein metabolic process (GO:0042157)	3.83989746
73	serine family amino acid catabolic process (GO:0009071)	3.80488816
74	regulation of cholesterol homeostasis (GO:2000188)	3.74845929
75	imidazole-containing compound metabolic process (GO:0052803)	3.73553567
76	positive regulation of extracellular matrix organization (GO:1903055)	3.72145107
77	negative regulation of wound healing (GO:0061045)	3.70938684
78	ethanol metabolic process (GO:0006067)	3.66621936
79	glucuronate metabolic process (GO:0019585)	3.65996574
80	uronic acid metabolic process (GO:0006063)	3.65996574
81	intestinal absorption (GO:0050892)	3.64954358
82	positive regulation of coagulation (GO:0050820)	3.63746313
83	bile acid and bile salt transport (GO:0015721)	3.55835616
84	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.54946639
85	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.54946639
86	proline metabolic process (GO:0006560)	3.54388878
87	regulation of triglyceride catabolic process (GO:0010896)	3.52668108
88	response to mercury ion (GO:0046689)	3.48353931
89	negative regulation of lipase activity (GO:0060192)	3.47204670
90	regulation of bile acid biosynthetic process (GO:0070857)	3.41082186
91	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.37809868
92	cholesterol homeostasis (GO:0042632)	3.36474672
93	negative regulation of humoral immune response (GO:0002921)	3.35327055
94	amino-acid betaine metabolic process (GO:0006577)	3.34366389
95	sterol homeostasis (GO:0055092)	3.31705145
96	acute inflammatory response (GO:0002526)	3.30811724
97	drug transmembrane transport (GO:0006855)	3.30370915
98	regulation of acute inflammatory response (GO:0002673)	3.29322033
99	regulation of cholesterol metabolic process (GO:0090181)	3.29175698
100	oxidative demethylation (GO:0070989)	3.25554903

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	9.86275125
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.80481523
3	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.94905572
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.91011339
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.41595628
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.22685933
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.81388425
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.79626033
9	FOXA2_19822575_ChIP-Seq_HepG2_Human	3.51187696
10	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.44179998
11	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.05991987
12	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.58078930
13	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.57869364
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.29070525
15	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.17791212
16	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.14894346
17	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.11752334
18	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.04101872
19	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.91512260
20	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.91185957
21	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.74135093
22	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.72759875
23	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.67034158
24	ZNF263_19887448_ChIP-Seq_K562_Human	1.66654884
25	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.61200034
26	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.52356673
27	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50632192
28	LXR_22292898_ChIP-Seq_THP-1_Human	1.47375732
29	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.45002195
30	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.41292411
31	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.34515985
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.33883492
33	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.33214816
34	GATA4_25053715_ChIP-Seq_YYC3_Human	1.32988154
35	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.32087321
36	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.26660293
37	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.22359871
38	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.19787986
39	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.15331080
40	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.14384564
41	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.13091215
42	GATA6_25053715_ChIP-Seq_YYC3_Human	1.11355059
43	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.09202917
44	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.08913644
45	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.07932655
46	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05060590
47	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.03941295
48	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.03940999
49	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.01673106
50	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.00643106
51	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.00587432
52	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.98937479
53	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.95043705
54	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.94831496
55	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.94458338
56	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93644293
57	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.92669508
58	SMC4_20622854_ChIP-Seq_HELA_Human	0.91035265
59	SOX2_20726797_ChIP-Seq_SW620_Human	0.90934063
60	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.89206984
61	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.88707029
62	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.88675455
63	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.86414102
64	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.86334404
65	RACK7_27058665_Chip-Seq_MCF-7_Human	0.85863962
66	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85515568
67	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.84981022
68	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.84964335
69	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.84524852
70	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.83645122
71	DROSHA_22980978_ChIP-Seq_HELA_Human	0.83486195
72	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.79485224
73	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.79260396
74	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.77394033
75	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.77127013
76	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.76632388
77	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.75846235
78	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.75374592
79	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.74174819
80	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.73993269
81	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.71863632
82	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.71160402
83	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.70461229
84	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.69651581
85	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.69600527
86	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.68920734
87	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.68540786
88	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.68034106
89	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.67932230
90	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.67413740
91	AR_21572438_ChIP-Seq_LNCaP_Human	0.64663693
92	KDM2B_26808549_Chip-Seq_K562_Human	0.64164538
93	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.61933650
94	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.61933650
95	AR_21909140_ChIP-Seq_LNCAP_Human	0.61823346
96	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.61783795
97	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.60103323
98	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.60023985
99	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.59949854
100	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.59421295

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.70910297
2	MP0005360_urolithiasis	5.89598524
3	MP0005365_abnormal_bile_salt	5.71497748
4	MP0005085_abnormal_gallbladder_physiolo	5.22740394
5	MP0008875_abnormal_xenobiotic_pharmacok	4.71582303
6	MP0003195_calcinosis	4.67801343
7	MP0003252_abnormal_bile_duct	3.99442830
8	MP0001666_abnormal_nutrient_absorption	3.70192944
9	MP0010329_abnormal_lipoprotein_level	3.29946290
10	MP0002138_abnormal_hepatobiliary_system	2.87174260
11	MP0003868_abnormal_feces_composition	2.71757746
12	MP0003122_maternal_imprinting	2.49045987
13	MP0010368_abnormal_lymphatic_system	2.36460245
14	MP0005332_abnormal_amino_acid	2.05360428
15	MP0009840_abnormal_foam_cell	2.00145141
16	MP0000609_abnormal_liver_physiology	1.91161196
17	MP0005670_abnormal_white_adipose	1.89710169
18	MP0003191_abnormal_cellular_cholesterol	1.81891675
19	MP0000566_synostosis	1.79630916
20	MP0002118_abnormal_lipid_homeostasis	1.72071512
21	MP0005408_hypopigmentation	1.65122085
22	MP0001915_intracranial_hemorrhage	1.57352227
23	MP0005058_abnormal_lysosome_morphology	1.56511040
24	MP0002132_abnormal_respiratory_system	1.50605570
25	MP0002089_abnormal_postnatal_growth/wei	1.41267150
26	MP0003172_abnormal_lysosome_physiology	1.29585757
27	MP0001661_extended_life_span	1.29455376
28	MP0005409_darkened_coat_color	1.28462448
29	MP0005451_abnormal_body_composition	1.24914340
30	MP0009780_abnormal_chondrocyte_physiolo	1.17666295
31	MP0002876_abnormal_thyroid_physiology	1.17591239
32	MP0004272_abnormal_basement_membrane	1.14450102
33	MP0003123_paternal_imprinting	1.11369454
34	MP0000598_abnormal_liver_morphology	1.09949325
35	MP0003879_abnormal_hair_cell	1.05413944
36	MP0004019_abnormal_vitamin_homeostasis	1.03574511
37	MP0005257_abnormal_intraocular_pressure	1.00117636
38	MP0005319_abnormal_enzyme/_coenzyme	0.99289523
39	MP0009643_abnormal_urine_homeostasis	0.93789407
40	MP0000604_amyloidosis	0.92734580
41	MP0001764_abnormal_homeostasis	0.90911251
42	MP0006054_spinal_hemorrhage	0.90487851
43	MP0005167_abnormal_blood-brain_barrier	0.90159676
44	MP0005636_abnormal_mineral_homeostasis	0.89506376
45	MP0008438_abnormal_cutaneous_collagen	0.87268365
46	MP0002933_joint_inflammation	0.86305747
47	MP0005023_abnormal_wound_healing	0.86027000
48	MP0003183_abnormal_peptide_metabolism	0.85724462
49	MP0003690_abnormal_glial_cell	0.85592816
50	MP0003656_abnormal_erythrocyte_physiolo	0.85342904
51	MP0003329_amyloid_beta_deposits	0.85088562
52	MP0009642_abnormal_blood_homeostasis	0.83197563
53	MP0000639_abnormal_adrenal_gland	0.83178813
54	MP0009697_abnormal_copulation	0.82200267
55	MP0002971_abnormal_brown_adipose	0.80611841
56	MP0003566_abnormal_cell_adhesion	0.79799839
57	MP0005584_abnormal_enzyme/coenzyme_acti	0.75998392
58	MP0003950_abnormal_plasma_membrane	0.72731901
59	MP0004264_abnormal_extraembryonic_tissu	0.71839151
60	MP0000920_abnormal_myelination	0.70990464
61	MP0001756_abnormal_urination	0.70464765
62	MP0002249_abnormal_larynx_morphology	0.67436978
63	MP0002282_abnormal_trachea_morphology	0.67218612
64	MP0003806_abnormal_nucleotide_metabolis	0.64533487
65	MP0005164_abnormal_response_to	0.64483741
66	MP0002078_abnormal_glucose_homeostasis	0.63895359
67	MP0005464_abnormal_platelet_physiology	0.61406209
68	MP0008469_abnormal_protein_level	0.59875181
69	MP0002909_abnormal_adrenal_gland	0.59614395
70	MP0005220_abnormal_exocrine_pancreas	0.59517705
71	MP0005076_abnormal_cell_differentiation	0.59490811
72	MP0009763_increased_sensitivity_to	0.58437477
73	MP0009384_cardiac_valve_regurgitation	0.57552831
74	MP0002168_other_aberrant_phenotype	0.56976671
75	MP0004782_abnormal_surfactant_physiolog	0.56008293
76	MP0009115_abnormal_fat_cell	0.55532044
77	MP0001270_distended_abdomen	0.54578852
78	MP0004043_abnormal_pH_regulation	0.53813111
79	MP0003632_abnormal_nervous_system	0.52551960
80	MP0004883_abnormal_blood_vessel	0.50877525
81	MP0000678_abnormal_parathyroid_gland	0.50121641
82	MP0005448_abnormal_energy_balance	0.50000923
83	MP0003300_gastrointestinal_ulcer	0.48572429
84	MP0003115_abnormal_respiratory_system	0.48505883
85	MP0000249_abnormal_blood_vessel	0.47532805
86	MP0003878_abnormal_ear_physiology	0.47024595
87	MP0005377_hearing/vestibular/ear_phenot	0.47024595
88	MP0000003_abnormal_adipose_tissue	0.46993596
89	MP0005376_homeostasis/metabolism_phenot	0.45767694
90	MP0008004_abnormal_stomach_pH	0.42995596
91	MP0005083_abnormal_biliary_tract	0.42023213
92	MP0003953_abnormal_hormone_level	0.41509593
93	MP0000858_altered_metastatic_potential	0.41490873
94	MP0002128_abnormal_blood_circulation	0.41394763
95	MP0002896_abnormal_bone_mineralization	0.41200308
96	MP0003075_altered_response_to	0.39662219
97	MP0005395_other_phenotype	0.39369561
98	MP0003638_abnormal_response/metabolism_	0.38172340
99	MP0003011_delayed_dark_adaptation	0.37930929
100	MP0005084_abnormal_gallbladder_morpholo	0.36627788

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Complement deficiency (HP:0004431)	9.22744117
2	Prolonged partial thromboplastin time (HP:0003645)	8.16727290
3	Abnormality of complement system (HP:0005339)	7.27068343
4	Hypobetalipoproteinemia (HP:0003563)	6.80646933
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.60972050
6	Glomerulonephritis (HP:0000099)	6.42633683
7	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.41232524
8	Joint hemorrhage (HP:0005261)	6.40996027
9	Systemic lupus erythematosus (HP:0002725)	6.24222901
10	Conjugated hyperbilirubinemia (HP:0002908)	6.01906964
11	Abnormality of the common coagulation pathway (HP:0010990)	4.87793477
12	Intrahepatic cholestasis (HP:0001406)	4.65979107
13	Xanthomatosis (HP:0000991)	4.55702967
14	Hypolipoproteinemia (HP:0010981)	4.18618832
15	Hyperlipoproteinemia (HP:0010980)	4.01561709
16	Spontaneous abortion (HP:0005268)	3.94648610
17	Nephritis (HP:0000123)	3.92194030
18	Hypercholesterolemia (HP:0003124)	3.88674813
19	Hemorrhage of the eye (HP:0011885)	3.74734122
20	Hypoalphalipoproteinemia (HP:0003233)	3.45719566
21	Recurrent gram-negative bacterial infections (HP:0005420)	3.36205226
22	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.32354181
23	Menorrhagia (HP:0000132)	3.28610277
24	Abnormality of the intrinsic pathway (HP:0010989)	3.27508896
25	Purpura (HP:0000979)	3.25582913
26	Vascular calcification (HP:0004934)	3.23756700
27	Fat malabsorption (HP:0002630)	3.21256010
28	Mitral stenosis (HP:0001718)	3.18922157
29	Epidermoid cyst (HP:0200040)	2.90480973
30	Cardiovascular calcification (HP:0011915)	2.86846417
31	Gingival bleeding (HP:0000225)	2.86829116
32	Hepatocellular carcinoma (HP:0001402)	2.63569778
33	Thrombophlebitis (HP:0004418)	2.56254205
34	Acanthocytosis (HP:0001927)	2.50261247
35	Myocardial infarction (HP:0001658)	2.47297431
36	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.46717612
37	Small epiphyses (HP:0010585)	2.44605552
38	Abnormality of carpal bone ossification (HP:0006257)	2.42794330
39	Abnormality of pyrimidine metabolism (HP:0004353)	2.28424675
40	Rickets (HP:0002748)	2.24325058
41	Skin nodule (HP:0200036)	2.22130191
42	Hypophosphatemic rickets (HP:0004912)	2.19360374
43	Abnormal tarsal ossification (HP:0008369)	2.19159467
44	Osteomalacia (HP:0002749)	2.14924374
45	Arthropathy (HP:0003040)	2.12471602
46	Pulmonary embolism (HP:0002204)	2.09452092
47	Flat acetabular roof (HP:0003180)	2.06793551
48	Protrusio acetabuli (HP:0003179)	2.03998867
49	Deep venous thrombosis (HP:0002625)	10.5174220
50	Cholecystitis (HP:0001082)	1.95741871
51	Abnormal gallbladder physiology (HP:0012438)	1.95741871
52	Abnormality of methionine metabolism (HP:0010901)	1.93091148
53	Abnormality of proline metabolism (HP:0010907)	1.90950831
54	Hydroxyprolinuria (HP:0003080)	1.90950831
55	Facial shape deformation (HP:0011334)	1.90011044
56	Potter facies (HP:0002009)	1.90011044
57	Hyperglycinemia (HP:0002154)	1.89074806
58	Abnormality of glycine metabolism (HP:0010895)	1.88480044
59	Abnormality of serine family amino acid metabolism (HP:0010894)	1.88480044
60	Peritonitis (HP:0002586)	1.88178628
61	Esophageal varix (HP:0002040)	1.87540152
62	Hyperglycinuria (HP:0003108)	1.85936715
63	Hyperammonemia (HP:0001987)	1.85421631
64	Abnormality of the Achilles tendon (HP:0005109)	1.84906700
65	Abnormal ossification of hand bones (HP:0005921)	1.84487026
66	Abnormal hand bone ossification (HP:0010660)	1.82348051
67	Increased serum pyruvate (HP:0003542)	1.80461514
68	Bifid scrotum (HP:0000048)	1.80296368
69	Poikilocytosis (HP:0004447)	1.77971136
70	Broad alveolar ridges (HP:0000187)	1.75435262
71	Abnormal delivery (HP:0001787)	1.74503047
72	Cholelithiasis (HP:0001081)	1.73999913
73	Vaginal fistula (HP:0004320)	1.73006998
74	Enlarged kidneys (HP:0000105)	1.72292685
75	Asymmetry of the thorax (HP:0001555)	1.70537128
76	Abnormality of glycolysis (HP:0004366)	1.67071825
77	Hyperbilirubinemia (HP:0002904)	1.66626599
78	Steatorrhea (HP:0002570)	1.65297088
79	Generalized aminoaciduria (HP:0002909)	1.65293031
80	Elevated alkaline phosphatase (HP:0003155)	1.64928946
81	Amyloidosis (HP:0011034)	1.64849823
82	Epiphyseal dysplasia (HP:0002656)	1.63614632
83	Epistaxis (HP:0000421)	1.61277079
84	Broad palm (HP:0001169)	1.60200899
85	Joint swelling (HP:0001386)	1.60192858
86	Abnormality of alkaline phosphatase activity (HP:0004379)	1.58646921
87	Abnormal gallbladder morphology (HP:0012437)	1.58643709
88	Pancreatic islet-cell hyperplasia (HP:0004510)	1.58603634
89	Abnormal enzyme/coenzyme activity (HP:0012379)	1.57366497
90	Abnormality of the nasal septum (HP:0000419)	1.57236593
91	Delayed CNS myelination (HP:0002188)	1.56959369
92	Biconcave vertebral bodies (HP:0004586)	1.56423026
93	Gout (HP:0001997)	1.54892261
94	Abnormality of nucleobase metabolism (HP:0010932)	1.53574401
95	Cerebral aneurysm (HP:0004944)	1.52721727
96	Neonatal death (HP:0003811)	1.51472903
97	Flared iliac wings (HP:0002869)	1.51129969
98	Pigmentary retinal degeneration (HP:0001146)	1.50813107
99	Hypoglycemic coma (HP:0001325)	1.50771069
100	Back pain (HP:0003418)	1.49824042

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	7.00839286
2	FGFR3	4.37916020
3	ERN1	3.43164369
4	ICK	3.32644662
5	RIPK1	3.19989434
6	WNK4	2.76592114
7	TRIB3	2.75195619
8	CDK12	2.53763418
9	PDGFRA	2.39859496
10	SIK1	2.35411627
11	PIK3CA	2.03624005
12	TYRO3	1.91725464
13	AKT3	1.80719640
14	FGFR2	1.79674327
15	EPHA3	1.71959594
16	PKN2	1.65088843
17	DDR2	1.58439643
18	LATS2	1.54525333
19	RET	1.52693174
20	FGFR1	1.48944351
21	MST1R	1.48826078
22	ERBB2	1.41314878
23	WNK1	1.30512399
24	TGFBR2	1.30004436
25	PRKAA2	1.29657203
26	TYK2	1.26703743
27	MAPK11	1.22514899
28	EPHA2	1.21670616
29	MET	1.21380287
30	NTRK3	1.19230589
31	EEF2K	1.18484679
32	PDPK1	1.15555649
33	DYRK1B	1.12516203
34	MAP3K2	1.11975681
35	LATS1	1.10321797
36	JAK1	1.02538213
37	CDC42BPA	1.00250347
38	SIK2	0.99241826
39	EPHB1	0.92332866
40	SGK223	0.87650578
41	SGK494	0.87650578
42	LMTK2	0.87112425
43	MAP3K3	0.83342475
44	MAPKAPK3	0.82949775
45	IRAK3	0.82721623
46	MAP3K7	0.81717381
47	MTOR	0.80140424
48	SGK1	0.79352258
49	FER	0.79067209
50	PDK1	0.75535697
51	MAP2K6	0.75507183
52	NEK9	0.73956945
53	PTK2	0.73188587
54	PRKACG	0.71057240
55	SGK3	0.70892236
56	SMG1	0.68690619
57	PDGFRB	0.68109395
58	NLK	0.65201880
59	PRKAA1	0.64585265
60	NTRK1	0.63141456
61	PTK6	0.61126270
62	MAP3K1	0.60910034
63	MARK2	0.59472098
64	EIF2AK1	0.55642186
65	CDK7	0.51050853
66	EPHA4	0.49775423
67	CSNK1E	0.48436187
68	FGR	0.48379527
69	SGK2	0.47941378
70	IGF1R	0.47449239
71	SRC	0.46334213
72	MAP3K6	0.45402745
73	RPS6KB1	0.44809875
74	STK39	0.44184515
75	CSF1R	0.43947399
76	CAMK4	0.43561757
77	STK38	0.42032820
78	NTRK2	0.39836677
79	JAK2	0.39728915
80	MAPK3	0.37671066
81	NEK6	0.37409109
82	RPS6KA3	0.36340718
83	PRKCZ	0.33131647
84	MATK	0.32388177
85	MAPK10	0.31436238
86	KSR2	0.31173263
87	PRKG1	0.30180465
88	ZAP70	0.29780867
89	CAMK1D	0.28824000
90	GSK3A	0.28771549
91	MAPK1	0.26446617
92	MAPKAPK2	0.26290613
93	CDK6	0.25004647
94	CSNK1D	0.24294313
95	MAPK15	0.23859403
96	BRSK1	0.22976833
97	MELK	0.21883924
98	NME1	0.21747453
99	ERBB4	0.21575257
100	BRD4	0.19922433

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	5.15841845
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.84262452
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.97386414
4	Caffeine metabolism_Homo sapiens_hsa00232	2.88108562
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.87072085
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.76164627
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.71897303
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.57711368
9	Retinol metabolism_Homo sapiens_hsa00830	2.56185794
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.32737472
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.27585138
12	Chemical carcinogenesis_Homo sapiens_hsa05204	2.24803325
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.21061447
14	Fatty acid degradation_Homo sapiens_hsa00071	2.20062135
15	Histidine metabolism_Homo sapiens_hsa00340	2.15736198
16	Tyrosine metabolism_Homo sapiens_hsa00350	2.15521522
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.03386247
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.02584055
19	Bile secretion_Homo sapiens_hsa04976	1.95428801
20	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.93279509
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.84438840
22	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.75875656
23	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.74548682
24	Fat digestion and absorption_Homo sapiens_hsa04975	1.66420461
25	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.62896073
26	Butanoate metabolism_Homo sapiens_hsa00650	1.58217819
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.56430450
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.52072039
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.49781171
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.49286190
31	ABC transporters_Homo sapiens_hsa02010	1.49158461
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.44379085
33	Prion diseases_Homo sapiens_hsa05020	1.42940118
34	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.42113429
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35567907
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.31793218
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.23721641
38	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20360099
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.19035637
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12565014
41	Other glycan degradation_Homo sapiens_hsa00511	1.08676642
42	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.08202950
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07153491
44	Peroxisome_Homo sapiens_hsa04146	0.98318629
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98199667
46	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.97310007
47	Steroid biosynthesis_Homo sapiens_hsa00100	0.88295076
48	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86721388
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85038044
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84743586
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83879823
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.82456713
53	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.81433459
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.80157560
55	Propanoate metabolism_Homo sapiens_hsa00640	0.77457326
56	Carbon metabolism_Homo sapiens_hsa01200	0.75401762
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73539204
58	Lysine degradation_Homo sapiens_hsa00310	0.69197733
59	Pertussis_Homo sapiens_hsa05133	0.67436374
60	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.66661827
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63092926
62	One carbon pool by folate_Homo sapiens_hsa00670	0.62470321
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.58342004
64	Insulin resistance_Homo sapiens_hsa04931	0.50971538
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.44991560
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43453514
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41833681
68	Galactose metabolism_Homo sapiens_hsa00052	0.38754664
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.38289665
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.36454239
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.33326057
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29561402
73	Metabolic pathways_Homo sapiens_hsa01100	0.29014676
74	Mineral absorption_Homo sapiens_hsa04978	0.26693990
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.24459098
76	AMPK signaling pathway_Homo sapiens_hsa04152	0.20513174
77	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.18918354
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.15066929
79	Amoebiasis_Homo sapiens_hsa05146	0.13321659
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.11803975
81	Fatty acid elongation_Homo sapiens_hsa00062	0.11639077
82	Insulin signaling pathway_Homo sapiens_hsa04910	0.11009169
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.11006686
84	Protein digestion and absorption_Homo sapiens_hsa04974	0.09293902
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.08938511
86	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.08525546
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.05348322
88	Sulfur relay system_Homo sapiens_hsa04122	0.05329124
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.04221382
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.03870573
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.03388239
92	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.03250285
93	Glutathione metabolism_Homo sapiens_hsa00480	0.00591209
94	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	-0.1083080
95	Choline metabolism in cancer_Homo sapiens_hsa05231	-0.1045971
96	HIF-1 signaling pathway_Homo sapiens_hsa04066	-0.0782737
97	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	-0.0723381
98	African trypanosomiasis_Homo sapiens_hsa05143	-0.0637910
99	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.0232369
100	Circadian rhythm_Homo sapiens_hsa04710	-0.0071446

C4B_2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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