ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of light stimulus involved in sensory perception (GO:0050962)	5.92512610
2	detection of light stimulus involved in visual perception (GO:0050908)	5.92512610
3	tachykinin receptor signaling pathway (GO:0007217)	4.60207661
4	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.53550388
5	indolalkylamine metabolic process (GO:0006586)	4.50589133
6	establishment of protein localization to Golgi (GO:0072600)	4.49462769
7	behavioral response to nicotine (GO:0035095)	4.31305600
8	piRNA metabolic process (GO:0034587)	4.18578712
9	multicellular organism reproduction (GO:0032504)	4.11577376
10	L-fucose catabolic process (GO:0042355)	4.11211267
11	fucose catabolic process (GO:0019317)	4.11211267
12	L-fucose metabolic process (GO:0042354)	4.11211267
13	tryptophan catabolic process (GO:0006569)	4.10408710
14	indole-containing compound catabolic process (GO:0042436)	4.10408710
15	indolalkylamine catabolic process (GO:0046218)	4.10408710
16	protein-chromophore linkage (GO:0018298)	4.08522556
17	cellular ketone body metabolic process (GO:0046950)	4.01226653
18	photoreceptor cell maintenance (GO:0045494)	4.00067943
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.97799075
20	neural tube formation (GO:0001841)	3.90648931
21	protein targeting to Golgi (GO:0000042)	3.83650028
22	behavioral response to ethanol (GO:0048149)	3.77378129
23	cilium or flagellum-dependent cell motility (GO:0001539)	3.76294649
24	DNA methylation involved in gamete generation (GO:0043046)	3.72919400
25	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.61685886
26	tryptophan metabolic process (GO:0006568)	3.61132359
27	rhodopsin mediated signaling pathway (GO:0016056)	3.54961295
28	ketone body metabolic process (GO:1902224)	3.47406087
29	sphingoid metabolic process (GO:0046519)	3.44181225
30	membrane depolarization during action potential (GO:0086010)	3.44040350
31	signal peptide processing (GO:0006465)	3.40430005
32	response to pheromone (GO:0019236)	3.38732033
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.37961790
34	axoneme assembly (GO:0035082)	3.34412538
35	kynurenine metabolic process (GO:0070189)	3.27207046
36	regulation of acrosome reaction (GO:0060046)	3.26878991
37	sperm motility (GO:0030317)	3.22437639
38	DNA integration (GO:0015074)	3.19160034
39	C4-dicarboxylate transport (GO:0015740)	3.14918128
40	central nervous system neuron axonogenesis (GO:0021955)	3.14804878
41	retinal cone cell development (GO:0046549)	3.12094342
42	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.11181593
43	cell wall macromolecule catabolic process (GO:0016998)	3.09552373
44	central nervous system projection neuron axonogenesis (GO:0021952)	3.09180569
45	acrosome reaction (GO:0007340)	3.07064349
46	epithelial cilium movement (GO:0003351)	3.06910382
47	protein prenylation (GO:0018342)	3.05372556
48	prenylation (GO:0097354)	3.05372556
49	indole-containing compound metabolic process (GO:0042430)	3.04788253
50	reflex (GO:0060004)	3.01813406
51	protein localization to Golgi apparatus (GO:0034067)	3.00090300
52	negative regulation of cAMP-mediated signaling (GO:0043951)	2.98784208
53	cellular biogenic amine catabolic process (GO:0042402)	2.97547340
54	amine catabolic process (GO:0009310)	2.97547340
55	left/right axis specification (GO:0070986)	2.97389222
56	negative regulation of mast cell activation (GO:0033004)	2.96614800
57	DNA deamination (GO:0045006)	2.95916730
58	calcium ion import (GO:0070509)	2.95536213
59	cell wall macromolecule metabolic process (GO:0044036)	2.91837469
60	NAD biosynthetic process (GO:0009435)	2.91306230
61	cellular response to sterol (GO:0036315)	2.90464264
62	regulation of cilium movement (GO:0003352)	2.88959473
63	cilium organization (GO:0044782)	2.84102782
64	phasic smooth muscle contraction (GO:0014821)	2.83200831
65	protein K11-linked deubiquitination (GO:0035871)	2.80683568
66	dopamine transport (GO:0015872)	2.78708421
67	sphingosine metabolic process (GO:0006670)	2.77829041
68	cilium assembly (GO:0042384)	2.77635981
69	cAMP catabolic process (GO:0006198)	2.74323495
70	regulation of hippo signaling (GO:0035330)	2.70812162
71	nonmotile primary cilium assembly (GO:0035058)	2.70637357
72	cilium movement (GO:0003341)	2.69885428
73	cyclic nucleotide catabolic process (GO:0009214)	2.68418811
74	proline transport (GO:0015824)	2.68007618
75	neuronal action potential propagation (GO:0019227)	2.66570090
76	thyroid hormone metabolic process (GO:0042403)	2.65571933
77	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.65065023
78	cilium morphogenesis (GO:0060271)	2.61840901
79	primary amino compound metabolic process (GO:1901160)	2.61499057
80	aromatic amino acid family catabolic process (GO:0009074)	2.59742802
81	opioid receptor signaling pathway (GO:0038003)	2.58648147
82	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.58578159
83	benzene-containing compound metabolic process (GO:0042537)	2.58227856
84	centriole replication (GO:0007099)	2.55940124
85	protein localization to cilium (GO:0061512)	2.54546369
86	regulation of gonadotropin secretion (GO:0032276)	2.53779068
87	positive regulation of developmental pigmentation (GO:0048087)	2.53625758
88	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.52757609
89	reciprocal meiotic recombination (GO:0007131)	2.52566279
90	reciprocal DNA recombination (GO:0035825)	2.52566279
91	visual perception (GO:0007601)	2.52510683
92	regulation of meiosis I (GO:0060631)	2.52001465
93	sensory perception of light stimulus (GO:0050953)	2.51760055
94	thrombin receptor signaling pathway (GO:0070493)	2.50936058
95	regulation of collateral sprouting (GO:0048670)	2.50537272
96	single strand break repair (GO:0000012)	2.50447074
97	histone H3-K4 trimethylation (GO:0080182)	2.46989691
98	double-strand break repair via homologous recombination (GO:0000724)	2.44756816
99	protein K63-linked deubiquitination (GO:0070536)	2.44238382
100	regulation of telomere maintenance (GO:0032204)	2.44087180

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.40222421
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.11584305
3	VDR_22108803_ChIP-Seq_LS180_Human	2.95716638
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59287836
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57051550
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.55179745
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.51850131
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.50965049
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.50932238
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42908063
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.39861299
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18539398
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.14315715
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.12797824
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06146591
16	P300_19829295_ChIP-Seq_ESCs_Human	2.04276105
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02553595
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.01094877
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.97634387
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.95981289
21	FUS_26573619_Chip-Seq_HEK293_Human	1.94558267
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89387663
23	STAT3_23295773_ChIP-Seq_U87_Human	1.87030576
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85127319
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.84941307
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.84868143
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74904372
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.72938094
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.72938094
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71593612
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.71593612
32	* TCF4_23295773_ChIP-Seq_U87_Human	1.67213658
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.65746180
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.64103904
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.64034920
36	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63720299
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57846610
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55752904
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55559859
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50804750
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50351586
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.50343431
43	EWS_26573619_Chip-Seq_HEK293_Human	1.50132106
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45869567
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.42550032
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42356589
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42356589
48	AR_25329375_ChIP-Seq_VCAP_Human	1.41463077
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38743792
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37420307
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37011720
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36721662
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35752478
54	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.35022473
55	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34401016
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.33436691
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.29273239
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28725287
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28088168
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26857300
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.26031666
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24780296
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23951333
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23177434
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20207426
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19875439
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19279336
68	DROSHA_22980978_ChIP-Seq_HELA_Human	1.17670199
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16868070
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16758318
71	AHR_22903824_ChIP-Seq_MCF-7_Human	1.15705413
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15035970
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14690776
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14655261
75	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.12796767
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12106121
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11845567
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11654962
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11398912
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11259401
81	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10743769
82	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09458744
83	RXR_22108803_ChIP-Seq_LS180_Human	1.08265756
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07461168
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06254115
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05960786
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05828700
88	KDM2B_26808549_Chip-Seq_REH_Human	1.05747569
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05534235
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02535041
91	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.02145604
92	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01755007
93	NCOR_22424771_ChIP-Seq_293T_Human	1.01686023
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01443453
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00950960
96	AR_20517297_ChIP-Seq_VCAP_Human	0.99797494
97	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99662867
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99390442
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99056469
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.99045737

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.11672450
2	MP0000372_irregular_coat_pigmentation	3.36784658
3	MP0002102_abnormal_ear_morphology	3.25386920
4	MP0005551_abnormal_eye_electrophysiolog	3.20000697
5	MP0008877_abnormal_DNA_methylation	3.16497629
6	MP0003950_abnormal_plasma_membrane	2.90276255
7	MP0002638_abnormal_pupillary_reflex	2.83945209
8	MP0003195_calcinosis	2.81667135
9	MP0003136_yellow_coat_color	2.42960813
10	MP0005670_abnormal_white_adipose	2.40060986
11	MP0008057_abnormal_DNA_replication	2.30908706
12	MP0001501_abnormal_sleep_pattern	2.26605391
13	MP0002876_abnormal_thyroid_physiology	2.14387941
14	MP0001486_abnormal_startle_reflex	2.04078059
15	MP0002837_dystrophic_cardiac_calcinosis	2.03028090
16	MP0003646_muscle_fatigue	2.01818156
17	MP0001968_abnormal_touch/_nociception	2.00192420
18	MP0004147_increased_porphyrin_level	1.99760145
19	MP0005253_abnormal_eye_physiology	1.88895215
20	MP0001984_abnormal_olfaction	1.86448033
21	MP0009046_muscle_twitch	1.82451559
22	MP0005174_abnormal_tail_pigmentation	1.81831402
23	MP0001986_abnormal_taste_sensitivity	1.75241159
24	MP0003045_fibrosis	1.73905169
25	MP0009745_abnormal_behavioral_response	1.72631983
26	MP0001485_abnormal_pinna_reflex	1.72078579
27	MP0005645_abnormal_hypothalamus_physiol	1.72002561
28	MP0005646_abnormal_pituitary_gland	1.70672993
29	MP0001764_abnormal_homeostasis	1.70574748
30	MP0008872_abnormal_physiological_respon	1.69820874
31	MP0003718_maternal_effect	1.67853704
32	MP0005410_abnormal_fertilization	1.61905519
33	MP0004142_abnormal_muscle_tone	1.57427488
34	MP0006276_abnormal_autonomic_nervous	1.52860029
35	MP0008875_abnormal_xenobiotic_pharmacok	1.52032372
36	MP0002653_abnormal_ependyma_morphology	1.50165823
37	MP0005360_urolithiasis	1.46212737
38	MP0004742_abnormal_vestibular_system	1.44155457
39	MP0005377_hearing/vestibular/ear_phenot	1.42571565
40	MP0003878_abnormal_ear_physiology	1.42571565
41	MP0000427_abnormal_hair_cycle	1.38204387
42	MP0002090_abnormal_vision	1.36213162
43	MP0005187_abnormal_penis_morphology	1.35523701
44	MP0003787_abnormal_imprinting	1.34592021
45	MP0003698_abnormal_male_reproductive	1.33283418
46	MP0002736_abnormal_nociception_after	1.33139703
47	MP0002735_abnormal_chemical_nociception	1.30908030
48	MP0005171_absent_coat_pigmentation	1.24731237
49	MP0004043_abnormal_pH_regulation	1.23366185
50	MP0002733_abnormal_thermal_nociception	1.23098815
51	MP0005395_other_phenotype	1.21483664
52	MP0002272_abnormal_nervous_system	1.19311806
53	MP0002168_other_aberrant_phenotype	1.19015667
54	MP0001929_abnormal_gametogenesis	1.16059962
55	MP0001529_abnormal_vocalization	1.15074269
56	MP0000383_abnormal_hair_follicle	1.15003225
57	MP0002928_abnormal_bile_duct	1.12941745
58	MP0003252_abnormal_bile_duct	1.12047504
59	MP0000538_abnormal_urinary_bladder	1.11540584
60	MP0003880_abnormal_central_pattern	1.10329860
61	MP0004885_abnormal_endolymph	1.08942910
62	MP0002822_catalepsy	1.08263426
63	MP0001970_abnormal_pain_threshold	1.08099506
64	MP0002572_abnormal_emotion/affect_behav	1.07422036
65	MP0005310_abnormal_salivary_gland	1.05764906
66	MP0001905_abnormal_dopamine_level	1.03080302
67	MP0001502_abnormal_circadian_rhythm	1.02341270
68	MP0002557_abnormal_social/conspecific_i	1.01982682
69	MP0002160_abnormal_reproductive_system	0.98910307
70	MP0003633_abnormal_nervous_system	0.97897889
71	MP0005389_reproductive_system_phenotype	0.97194704
72	MP0006292_abnormal_olfactory_placode	0.96149123
73	MP0002064_seizures	0.95691644
74	MP0006072_abnormal_retinal_apoptosis	0.93864270
75	MP0000371_diluted_coat_color	0.93777775
76	MP0005386_behavior/neurological_phenoty	0.93636900
77	MP0004924_abnormal_behavior	0.93636900
78	MP0002938_white_spotting	0.92202687
79	MP0002229_neurodegeneration	0.92111210
80	MP0005195_abnormal_posterior_eye	0.92089996
81	MP0002095_abnormal_skin_pigmentation	0.88023165
82	MP0000230_abnormal_systemic_arterial	0.86944378
83	MP0004215_abnormal_myocardial_fiber	0.85288095
84	MP0008058_abnormal_DNA_repair	0.84539574
85	MP0002067_abnormal_sensory_capabilities	0.84028311
86	MP0005075_abnormal_melanosome_morpholog	0.82221190
87	MP0005266_abnormal_metabolism	0.80504659
88	MP0003635_abnormal_synaptic_transmissio	0.79330359
89	MP0001963_abnormal_hearing_physiology	0.77308063
90	MP0002210_abnormal_sex_determination	0.75902088
91	MP0002752_abnormal_somatic_nervous	0.75678236
92	MP0003943_abnormal_hepatobiliary_system	0.75468558
93	MP0003631_nervous_system_phenotype	0.74470563
94	MP0000653_abnormal_sex_gland	0.74118764
95	MP0005376_homeostasis/metabolism_phenot	0.74107065
96	MP0002693_abnormal_pancreas_physiology	0.73641318
97	MP0001545_abnormal_hematopoietic_system	0.72556294
98	MP0005397_hematopoietic_system_phenotyp	0.72556294
99	MP0005167_abnormal_blood-brain_barrier	0.71356969
100	MP0008775_abnormal_heart_ventricle	0.70916359

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.04594583
2	Pancreatic cysts (HP:0001737)	4.28829678
3	Chronic hepatic failure (HP:0100626)	4.28202765
4	Abnormal rod and cone electroretinograms (HP:0008323)	4.15111158
5	Abnormality of macular pigmentation (HP:0008002)	3.86413767
6	Molar tooth sign on MRI (HP:0002419)	3.71609065
7	Abnormality of midbrain morphology (HP:0002418)	3.71609065
8	True hermaphroditism (HP:0010459)	3.65647021
9	Central scotoma (HP:0000603)	3.61461484
10	Pancreatic fibrosis (HP:0100732)	3.61231503
11	Abnormality of the renal cortex (HP:0011035)	3.55910423
12	Attenuation of retinal blood vessels (HP:0007843)	3.32244939
13	Severe visual impairment (HP:0001141)	3.27057369
14	Gaze-evoked nystagmus (HP:0000640)	3.21907520
15	Abnormality of the renal medulla (HP:0100957)	3.11217263
16	Nephronophthisis (HP:0000090)	3.06263276
17	Cystic liver disease (HP:0006706)	3.01030359
18	Focal seizures (HP:0007359)	2.98847153
19	Focal motor seizures (HP:0011153)	2.97484027
20	Medial flaring of the eyebrow (HP:0010747)	2.95145193
21	Genetic anticipation (HP:0003743)	2.93254174
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.91465866
23	Hypoplasia of the fovea (HP:0007750)	2.82397695
24	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.82397695
25	Progressive cerebellar ataxia (HP:0002073)	2.80461861
26	Volvulus (HP:0002580)	2.77435014
27	Tubular atrophy (HP:0000092)	2.65167144
28	Pendular nystagmus (HP:0012043)	2.57653586
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.56231135
30	Optic nerve hypoplasia (HP:0000609)	2.54759670
31	Sclerocornea (HP:0000647)	2.53005671
32	Hyperventilation (HP:0002883)	2.51452271
33	Decreased central vision (HP:0007663)	2.51290496
34	Renal cortical cysts (HP:0000803)	2.49273435
35	Abnormality of the labia minora (HP:0012880)	2.49137533
36	Scotoma (HP:0000575)	2.48181083
37	Congenital primary aphakia (HP:0007707)	2.47686590
38	Gait imbalance (HP:0002141)	2.46717519
39	Absent speech (HP:0001344)	2.45258753
40	Abnormality of the fovea (HP:0000493)	2.44736161
41	Abnormal biliary tract physiology (HP:0012439)	2.42768264
42	Bile duct proliferation (HP:0001408)	2.42768264
43	Aplasia/Hypoplasia of the macula (HP:0008059)	2.41651801
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.38223851
45	Constricted visual fields (HP:0001133)	2.37257629
46	Febrile seizures (HP:0002373)	2.35331405
47	Tubulointerstitial nephritis (HP:0001970)	2.32357067
48	Abolished electroretinogram (ERG) (HP:0000550)	2.28129096
49	Dialeptic seizures (HP:0011146)	2.27481682
50	Keratoconus (HP:0000563)	2.22723060
51	Increased corneal curvature (HP:0100692)	2.22723060
52	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.21126064
53	Polydipsia (HP:0001959)	2.20969112
54	Abnormal drinking behavior (HP:0030082)	2.20969112
55	Absent/shortened dynein arms (HP:0200106)	2.20505816
56	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20505816
57	Albinism (HP:0001022)	2.18781527
58	Supernumerary spleens (HP:0009799)	2.17976895
59	Hypothermia (HP:0002045)	2.14070420
60	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.11496229
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10804195
62	Stomach cancer (HP:0012126)	2.10378910
63	Nephrogenic diabetes insipidus (HP:0009806)	2.10342375
64	Cerebellar dysplasia (HP:0007033)	2.09274874
65	Occipital encephalocele (HP:0002085)	2.08839828
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.08838654
67	Poor coordination (HP:0002370)	2.06362109
68	Thyroid-stimulating hormone excess (HP:0002925)	2.03618594
69	Congenital hepatic fibrosis (HP:0002612)	2.02183131
70	Broad-based gait (HP:0002136)	2.01059682
71	Anencephaly (HP:0002323)	2.00373037
72	Chromsome breakage (HP:0040012)	1.99580881
73	Tubulointerstitial abnormality (HP:0001969)	1.96263986
74	Genital tract atresia (HP:0001827)	1.94034685
75	Large for gestational age (HP:0001520)	1.93778430
76	Vaginal atresia (HP:0000148)	1.93727277
77	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.92224039
78	Generalized hypopigmentation of hair (HP:0011358)	1.91133704
79	Furrowed tongue (HP:0000221)	1.90651203
80	Inability to walk (HP:0002540)	1.88129053
81	Retinitis pigmentosa (HP:0000510)	1.85516303
82	Abnormal ciliary motility (HP:0012262)	1.84150666
83	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.83312403
84	Protruding tongue (HP:0010808)	1.82961710
85	Macular degeneration (HP:0000608)	1.82245254
86	Widely spaced teeth (HP:0000687)	1.81537168
87	Polyuria (HP:0000103)	1.81299723
88	Decreased circulating renin level (HP:0003351)	1.81270727
89	Astigmatism (HP:0000483)	1.80452498
90	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79741101
91	Highly arched eyebrow (HP:0002553)	1.79269791
92	Bilateral sensorineural hearing impairment (HP:0008619)	1.77551946
93	Type II lissencephaly (HP:0007260)	1.77331487
94	Male pseudohermaphroditism (HP:0000037)	1.76937148
95	Intestinal atresia (HP:0011100)	1.76736092
96	Amelogenesis imperfecta (HP:0000705)	1.76354607
97	Hypoplastic labia majora (HP:0000059)	1.74792515
98	Partial agenesis of the corpus callosum (HP:0001338)	1.74710107
99	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.73330989
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.72205114

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.43887694
2	ADRBK2	3.45773849
3	TAOK3	2.80848945
4	MAP4K2	2.34088580
5	PINK1	2.20315081
6	GRK1	2.09021659
7	STK38L	2.00938195
8	TNK2	1.99013171
9	BMPR1B	1.97039236
10	ZAK	1.95511357
11	WNK3	1.91367445
12	NUAK1	1.89829429
13	MAPK13	1.84222190
14	TEC	1.59582163
15	ACVR1B	1.58607275
16	PAK3	1.53824989
17	CASK	1.51807802
18	GRK7	1.42861484
19	PIK3CG	1.41974982
20	INSRR	1.40139530
21	LATS1	1.38634511
22	PTK2B	1.31061973
23	TNIK	1.27991674
24	OXSR1	1.27447144
25	STK39	1.20903051
26	ADRBK1	1.18489977
27	PRKCE	1.14253183
28	PIK3CA	1.11637539
29	PLK2	1.08182825
30	MAP3K4	1.06996198
31	ITK	1.06844454
32	EIF2AK3	1.04747550
33	TXK	1.02661939
34	MARK3	1.00378600
35	MAP3K7	0.99151102
36	CAMK1G	0.96228738
37	AKT3	0.91607291
38	NLK	0.88403766
39	CDK3	0.87610352
40	BRD4	0.83633225
41	STK16	0.83250415
42	KIT	0.80832593
43	BRSK2	0.80481411
44	FER	0.78296939
45	PRKCG	0.76747438
46	MKNK2	0.75256739
47	NTRK3	0.74716417
48	FGFR2	0.74183084
49	PNCK	0.74070312
50	PKN1	0.73270548
51	CAMK1	0.71194806
52	PRKAA2	0.68688158
53	SIK2	0.68502089
54	PRKCQ	0.67256102
55	WNK4	0.63690171
56	CAMK1D	0.63215351
57	STK38	0.61893771
58	MARK1	0.60870561
59	TRIM28	0.58241280
60	DAPK2	0.57483537
61	CSNK1A1L	0.57028010
62	STK3	0.56749932
63	BTK	0.55105557
64	BCKDK	0.53582503
65	EPHA4	0.53191104
66	PRKD3	0.50087491
67	PRKAA1	0.49980657
68	ERBB3	0.49118542
69	TLK1	0.48573249
70	CAMK2A	0.48339791
71	CAMK4	0.47464573
72	TRPM7	0.46874746
73	IKBKB	0.46276223
74	GRK5	0.44659406
75	PRKACA	0.44329392
76	WEE1	0.43597414
77	ERBB2	0.43264216
78	PDK2	0.42039094
79	SIK3	0.41814053
80	KDR	0.40435818
81	ATR	0.40429982
82	VRK1	0.40389766
83	RPS6KA5	0.39616906
84	PRKCB	0.37620662
85	PRKG1	0.37295884
86	CSNK1D	0.36891529
87	PRKACB	0.36598602
88	MKNK1	0.36495043
89	MAP2K6	0.35938011
90	NME1	0.35038482
91	TGFBR2	0.34242235
92	IRAK1	0.33810436
93	SYK	0.33321532
94	PLK4	0.32777439
95	CDC7	0.32705325
96	MELK	0.32404462
97	CSNK1A1	0.32015390
98	MAPK11	0.31855497
99	SGK2	0.30054749
100	LYN	0.29391832

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.30840793
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.14451878
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.98534587
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.74629978
5	Butanoate metabolism_Homo sapiens_hsa00650	2.68629738
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.65378333
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.50321928
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15897998
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.09303178
10	Olfactory transduction_Homo sapiens_hsa04740	2.09134693
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.07600904
12	ABC transporters_Homo sapiens_hsa02010	2.00641540
13	Taste transduction_Homo sapiens_hsa04742	1.94655023
14	Caffeine metabolism_Homo sapiens_hsa00232	1.90902882
15	Nicotine addiction_Homo sapiens_hsa05033	1.85147909
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.84223022
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80853925
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.72596507
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.71154654
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.70673659
21	Morphine addiction_Homo sapiens_hsa05032	1.68735198
22	Homologous recombination_Homo sapiens_hsa03440	1.65201518
23	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.61505259
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.60630737
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.57836562
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52286325
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51229542
28	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.50206071
29	Serotonergic synapse_Homo sapiens_hsa04726	1.46080823
30	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.45978245
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33748146
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.30679999
33	Glycerolipid metabolism_Homo sapiens_hsa00561	1.29256876
34	Retinol metabolism_Homo sapiens_hsa00830	1.28054940
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.27687806
36	Propanoate metabolism_Homo sapiens_hsa00640	1.25927679
37	Circadian entrainment_Homo sapiens_hsa04713	1.22894875
38	One carbon pool by folate_Homo sapiens_hsa00670	1.22818963
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.20174070
40	Sphingolipid metabolism_Homo sapiens_hsa00600	1.18527134
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.12905299
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.11003366
43	Peroxisome_Homo sapiens_hsa04146	1.09435832
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.06001349
45	GABAergic synapse_Homo sapiens_hsa04727	1.05347679
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.04230717
47	Lysine degradation_Homo sapiens_hsa00310	1.03142921
48	Salivary secretion_Homo sapiens_hsa04970	1.02972874
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01984345
50	Non-homologous end-joining_Homo sapiens_hsa03450	1.01662897
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00747210
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95218981
53	Histidine metabolism_Homo sapiens_hsa00340	0.94713793
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.91441127
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.84401758
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82088534
57	Basal transcription factors_Homo sapiens_hsa03022	0.80093988
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.79942684
59	Insulin secretion_Homo sapiens_hsa04911	0.78571196
60	Fatty acid degradation_Homo sapiens_hsa00071	0.77325473
61	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75160164
62	Cholinergic synapse_Homo sapiens_hsa04725	0.73190790
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72376852
64	Renin secretion_Homo sapiens_hsa04924	0.67875853
65	Regulation of autophagy_Homo sapiens_hsa04140	0.67759304
66	RNA polymerase_Homo sapiens_hsa03020	0.63429631
67	Purine metabolism_Homo sapiens_hsa00230	0.62733951
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62618607
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.60886651
70	Mineral absorption_Homo sapiens_hsa04978	0.58295912
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.58284700
72	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.57640157
73	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.57272703
74	Circadian rhythm_Homo sapiens_hsa04710	0.56072699
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.54271478
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54166682
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54138487
78	Platelet activation_Homo sapiens_hsa04611	0.53206017
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.46886930
80	Pancreatic secretion_Homo sapiens_hsa04972	0.45550254
81	Metabolic pathways_Homo sapiens_hsa01100	0.44427046
82	Glutathione metabolism_Homo sapiens_hsa00480	0.43636571
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42956063
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42470261
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.35588388
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.35223313
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34267807
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.33003719
89	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.32643371
90	Long-term depression_Homo sapiens_hsa04730	0.32081852
91	Complement and coagulation cascades_Homo sapiens_hsa04610	0.31979883
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29266103
93	RNA degradation_Homo sapiens_hsa03018	0.26806222
94	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.25751626
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.25328039
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.22099270
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.21960733
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.21480935
99	Gastric acid secretion_Homo sapiens_hsa04971	0.20293191
100	Huntingtons disease_Homo sapiens_hsa05016	0.19648914

C4ORF17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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