ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	exogenous drug catabolic process (GO:0042738)	5.42712455
2	drug catabolic process (GO:0042737)	5.22313365
3	epoxygenase P450 pathway (GO:0019373)	5.07386051
4	cellular glucuronidation (GO:0052695)	4.57379025
5	uronic acid metabolic process (GO:0006063)	4.51093127
6	glucuronate metabolic process (GO:0019585)	4.51093127
7	cellular ketone body metabolic process (GO:0046950)	4.25658047
8	flavonoid metabolic process (GO:0009812)	4.05021430
9	ketone body metabolic process (GO:1902224)	4.05007994
10	fucose catabolic process (GO:0019317)	4.02042773
11	L-fucose metabolic process (GO:0042354)	4.02042773
12	L-fucose catabolic process (GO:0042355)	4.02042773
13	prostate gland growth (GO:0060736)	3.95368600
14	regulation of triglyceride catabolic process (GO:0010896)	3.94588497
15	arginine metabolic process (GO:0006525)	3.92813214
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.87912547
17	omega-hydroxylase P450 pathway (GO:0097267)	3.85650142
18	drug metabolic process (GO:0017144)	3.85071581
19	intestinal absorption (GO:0050892)	3.76958263
20	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.71438410
21	oxidative demethylation (GO:0070989)	3.60615641
22	bile acid and bile salt transport (GO:0015721)	3.55751665
23	indole-containing compound catabolic process (GO:0042436)	3.55639993
24	indolalkylamine catabolic process (GO:0046218)	3.55639993
25	tryptophan catabolic process (GO:0006569)	3.55639993
26	cilium or flagellum-dependent cell motility (GO:0001539)	3.48811720
27	bile acid metabolic process (GO:0008206)	3.47612932
28	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.46700655
29	piRNA metabolic process (GO:0034587)	3.45867775
30	phenylpropanoid metabolic process (GO:0009698)	3.32163011
31	alkaloid metabolic process (GO:0009820)	3.31900004
32	quinone biosynthetic process (GO:1901663)	3.28245884
33	epithelial cilium movement (GO:0003351)	3.24682554
34	glyoxylate metabolic process (GO:0046487)	3.23109428
35	water-soluble vitamin biosynthetic process (GO:0042364)	3.22537849
36	S-adenosylmethionine metabolic process (GO:0046500)	3.21763688
37	axoneme assembly (GO:0035082)	3.17611961
38	tryptophan metabolic process (GO:0006568)	3.15301434
39	digestion (GO:0007586)	3.15164376
40	preassembly of GPI anchor in ER membrane (GO:0016254)	3.13956403
41	drug transmembrane transport (GO:0006855)	3.12263096
42	xenobiotic catabolic process (GO:0042178)	3.11239856
43	cilium movement (GO:0003341)	3.10687339
44	vitamin transmembrane transport (GO:0035461)	3.10421979
45	aromatic amino acid family catabolic process (GO:0009074)	3.08691314
46	intestinal cholesterol absorption (GO:0030299)	3.06474331
47	indolalkylamine metabolic process (GO:0006586)	3.03774290
48	regulation of acrosome reaction (GO:0060046)	3.02844973
49	bile acid biosynthetic process (GO:0006699)	3.00919654
50	intestinal epithelial cell development (GO:0060576)	2.98696804
51	axonemal dynein complex assembly (GO:0070286)	2.96851958
52	regulation of guanylate cyclase activity (GO:0031282)	2.93905265
53	regulation of hippo signaling (GO:0035330)	2.93743766
54	kynurenine metabolic process (GO:0070189)	2.92788938
55	ethanol oxidation (GO:0006069)	2.91636007
56	mannosylation (GO:0097502)	2.91046914
57	heme transport (GO:0015886)	2.90496712
58	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.89545669
59	amino-acid betaine metabolic process (GO:0006577)	2.86333106
60	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.86171876
61	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.86171876
62	sulfur amino acid catabolic process (GO:0000098)	2.85451011
63	sulfur compound transport (GO:0072348)	2.85343126
64	vitamin biosynthetic process (GO:0009110)	2.84362709
65	fucosylation (GO:0036065)	2.82530380
66	nucleotide transmembrane transport (GO:1901679)	2.82206435
67	arginine catabolic process (GO:0006527)	2.81840548
68	ethanol metabolic process (GO:0006067)	2.81530130
69	behavioral response to nicotine (GO:0035095)	2.81353712
70	response to nitrosative stress (GO:0051409)	2.80221039
71	vitamin transport (GO:0051180)	2.77810020
72	benzene-containing compound metabolic process (GO:0042537)	2.76066154
73	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.74929760
74	quinone metabolic process (GO:1901661)	2.73985911
75	transepithelial transport (GO:0070633)	2.73584923
76	L-methionine biosynthetic process (GO:0071265)	2.73409900
77	amino acid salvage (GO:0043102)	2.73409900
78	L-methionine salvage (GO:0071267)	2.73409900
79	DNA methylation involved in gamete generation (GO:0043046)	2.71824081
80	drug transport (GO:0015893)	2.71184147
81	xenobiotic metabolic process (GO:0006805)	2.70946421
82	primary alcohol catabolic process (GO:0034310)	2.70112996
83	positive regulation of fatty acid transport (GO:2000193)	2.67643183
84	positive regulation of icosanoid secretion (GO:0032305)	2.66823918
85	transcytosis (GO:0045056)	2.61860702
86	short-chain fatty acid metabolic process (GO:0046459)	2.58892652
87	glycerol metabolic process (GO:0006071)	2.58504821
88	DNA deamination (GO:0045006)	2.57441842
89	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.57341964
90	auditory receptor cell stereocilium organization (GO:0060088)	2.57319015
91	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.55874050
92	L-phenylalanine catabolic process (GO:0006559)	2.55874050
93	ubiquinone biosynthetic process (GO:0006744)	2.55440336
94	glutathione derivative metabolic process (GO:1901685)	2.53083658
95	glutathione derivative biosynthetic process (GO:1901687)	2.53083658
96	GPI anchor metabolic process (GO:0006505)	2.52549966
97	multicellular organism reproduction (GO:0032504)	2.49658753
98	photoreceptor cell maintenance (GO:0045494)	2.49402793
99	macroautophagy (GO:0016236)	2.48765510
100	urate metabolic process (GO:0046415)	2.48301336

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ESR1_20079471_ChIP-ChIP_T-47D_Human	3.61640656
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34868102
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.19236461
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.16854825
5	VDR_22108803_ChIP-Seq_LS180_Human	2.69335312
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.66826370
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21265316
8	GATA4_25053715_ChIP-Seq_YYC3_Human	2.05025213
9	ER_23166858_ChIP-Seq_MCF-7_Human	1.98949744
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.96295580
11	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.92861349
12	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.86223112
13	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.75028023
14	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.71262971
15	BCAT_22108803_ChIP-Seq_LS180_Human	1.64696675
16	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.62831369
17	AHR_22903824_ChIP-Seq_MCF-7_Human	1.61510652
18	AR_20517297_ChIP-Seq_VCAP_Human	1.60006443
19	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.59755452
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.59312449
21	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.59272533
22	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.59272533
23	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.57605112
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.57372841
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57072346
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55747590
27	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.55588645
28	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.55437771
29	HOXB7_26014856_ChIP-Seq_BT474_Human	1.53469048
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53385329
31	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.53282238
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52622500
33	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.52588189
34	* CDX2_22108803_ChIP-Seq_LS180_Human	1.51989617
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.51560850
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51560850
37	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.50014978
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.49660368
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48741940
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48018264
41	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.47588034
42	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.45037663
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.44744558
44	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.41808828
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41468350
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41040781
47	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.38951668
48	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.38682983
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.38400744
50	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.36272999
51	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.34956650
52	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.34644258
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.32656159
54	GATA6_25053715_ChIP-Seq_YYC3_Human	1.31956351
55	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.29728434
56	P300_19829295_ChIP-Seq_ESCs_Human	1.29661554
57	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28829237
58	* FOXA1_25552417_ChIP-Seq_VCAP_Human	1.27630842
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26777288
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.25879632
61	NCOR_22424771_ChIP-Seq_293T_Human	1.25159397
62	AR_25329375_ChIP-Seq_VCAP_Human	1.24393224
63	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23039374
64	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20924056
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17312045
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16368719
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15844969
68	* TCF4_23295773_ChIP-Seq_U87_Human	1.14913526
69	STAT3_23295773_ChIP-Seq_U87_Human	1.14651406
70	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.14496866
71	CBP_21632823_ChIP-Seq_H3396_Human	1.14362217
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14323899
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12593102
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.12082333
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10326812
76	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09955360
77	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09872398
78	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.09555926
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.08111113
80	* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07361420
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06912759
82	* SOX2_20726797_ChIP-Seq_SW620_Human	1.06394493
83	* ELF5_23300383_ChIP-Seq_T47D_Human	1.05863935
84	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.05835925
85	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.05835925
86	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05359995
87	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.03969194
88	ERA_21632823_ChIP-Seq_H3396_Human	1.03867910
89	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.03587384
90	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.03455095
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03437995
92	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03425717
93	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02551821
94	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02317464
95	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00412072
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00220081
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99310391
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98955968
99	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.94543877
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94167426

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.07528986
2	MP0005360_urolithiasis	3.96468785
3	MP0005085_abnormal_gallbladder_physiolo	3.96412060
4	MP0005365_abnormal_bile_salt	3.65839770
5	MP0001666_abnormal_nutrient_absorption	3.56542253
6	MP0010234_abnormal_vibrissa_follicle	3.47916245
7	MP0008875_abnormal_xenobiotic_pharmacok	3.26710990
8	MP0002876_abnormal_thyroid_physiology	3.09400376
9	MP0003195_calcinosis	3.08501662
10	MP0004147_increased_porphyrin_level	2.77248201
11	MP0002254_reproductive_system_inflammat	2.58150124
12	MP0000427_abnormal_hair_cycle	2.52394917
13	MP0002138_abnormal_hepatobiliary_system	2.51596158
14	MP0004264_abnormal_extraembryonic_tissu	2.46925244
15	MP0003252_abnormal_bile_duct	2.34989718
16	MP0010329_abnormal_lipoprotein_level	2.30918125
17	MP0003718_maternal_effect	2.25194811
18	MP0004019_abnormal_vitamin_homeostasis	2.24671194
19	MP0004043_abnormal_pH_regulation	2.10146355
20	MP0003806_abnormal_nucleotide_metabolis	2.04394303
21	MP0003183_abnormal_peptide_metabolism	2.01100802
22	MP0010678_abnormal_skin_adnexa	1.95559336
23	MP0005408_hypopigmentation	1.91571927
24	MP0005083_abnormal_biliary_tract	1.88346217
25	MP0002098_abnormal_vibrissa_morphology	1.80336171
26	MP0008872_abnormal_physiological_respon	1.78529278
27	MP0001664_abnormal_digestion	1.75231905
28	MP0000383_abnormal_hair_follicle	1.74358133
29	MP0003868_abnormal_feces_composition	1.72562800
30	MP0000566_synostosis	1.69466994
31	MP0005636_abnormal_mineral_homeostasis	1.68568052
32	MP0001765_abnormal_ion_homeostasis	1.65898279
33	MP0009780_abnormal_chondrocyte_physiolo	1.64572536
34	MP0005379_endocrine/exocrine_gland_phen	1.62717589
35	MP0001346_abnormal_lacrimal_gland	1.60256947
36	MP0005332_abnormal_amino_acid	1.57295065
37	MP0008877_abnormal_DNA_methylation	1.51797842
38	MP0005248_abnormal_Harderian_gland	1.47847895
39	MP0005551_abnormal_eye_electrophysiolog	1.46077225
40	MP0001919_abnormal_reproductive_system	1.45323032
41	MP0004782_abnormal_surfactant_physiolog	1.44778856
42	MP0001764_abnormal_homeostasis	1.43778289
43	MP0002653_abnormal_ependyma_morphology	1.38226353
44	MP0002102_abnormal_ear_morphology	1.36163383
45	MP0009643_abnormal_urine_homeostasis	1.35499929
46	MP0003011_delayed_dark_adaptation	1.34246703
47	MP0005646_abnormal_pituitary_gland	1.22699836
48	MP0002118_abnormal_lipid_homeostasis	1.22682752
49	MP0009840_abnormal_foam_cell	1.19886593
50	MP0002909_abnormal_adrenal_gland	1.19062665
51	MP0001873_stomach_inflammation	1.18298634
52	MP0001881_abnormal_mammary_gland	1.10346651
53	MP0005389_reproductive_system_phenotype	1.09560396
54	MP0005645_abnormal_hypothalamus_physiol	1.04849746
55	MP0005395_other_phenotype	1.04591600
56	MP0001756_abnormal_urination	1.01771839
57	MP0002796_impaired_skin_barrier	1.00220792
58	MP0003638_abnormal_response/metabolism_	0.98128184
59	MP0005319_abnormal_enzyme/_coenzyme	0.94916205
60	MP0005377_hearing/vestibular/ear_phenot	0.93702304
61	MP0003878_abnormal_ear_physiology	0.93702304
62	MP0005253_abnormal_eye_physiology	0.93658256
63	MP0003866_abnormal_defecation	0.93266440
64	MP0005075_abnormal_melanosome_morpholog	0.91204390
65	MP0005174_abnormal_tail_pigmentation	0.90286189
66	MP0000372_irregular_coat_pigmentation	0.84685026
67	MP0001501_abnormal_sleep_pattern	0.84211230
68	MP0001986_abnormal_taste_sensitivity	0.84176469
69	MP0002282_abnormal_trachea_morphology	0.84070099
70	MP0000470_abnormal_stomach_morphology	0.83292738
71	MP0003646_muscle_fatigue	0.82743605
72	MP0000627_abnormal_mammary_gland	0.81010510
73	MP0001944_abnormal_pancreas_morphology	0.80855162
74	MP0006072_abnormal_retinal_apoptosis	0.80122570
75	MP0003953_abnormal_hormone_level	0.79364302
76	MP0000609_abnormal_liver_physiology	0.79265514
77	MP0003936_abnormal_reproductive_system	0.77085938
78	MP0000377_abnormal_hair_follicle	0.76582335
79	MP0000647_abnormal_sebaceous_gland	0.75998204
80	MP0005084_abnormal_gallbladder_morpholo	0.75257138
81	MP0002136_abnormal_kidney_physiology	0.72543319
82	MP0010155_abnormal_intestine_physiology	0.67278180
83	MP0005448_abnormal_energy_balance	0.66421098
84	MP0002277_abnormal_respiratory_mucosa	0.65434671
85	MP0001485_abnormal_pinna_reflex	0.63162074
86	MP0000230_abnormal_systemic_arterial	0.62116480
87	MP0002160_abnormal_reproductive_system	0.61779606
88	MP0002928_abnormal_bile_duct	0.60935607
89	MP0002693_abnormal_pancreas_physiology	0.60055117
90	MP0009642_abnormal_blood_homeostasis	0.58874704
91	MP0001663_abnormal_digestive_system	0.58560199
92	MP0003186_abnormal_redox_activity	0.58438474
93	MP0001324_abnormal_eye_pigmentation	0.58343656
94	MP0005670_abnormal_white_adipose	0.56961904
95	MP0006276_abnormal_autonomic_nervous	0.56566246
96	MP0000467_abnormal_esophagus_morphology	0.55351840
97	MP0002078_abnormal_glucose_homeostasis	0.55023766
98	MP0003879_abnormal_hair_cell	0.53666969
99	MP0005410_abnormal_fertilization	0.53157122
100	MP0001929_abnormal_gametogenesis	0.52872344

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.10801493
2	Concave nail (HP:0001598)	3.69212198
3	Decreased circulating renin level (HP:0003351)	3.63889401
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.48911540
5	Abnormality of the renal cortex (HP:0011035)	3.42565670
6	Absent/shortened dynein arms (HP:0200106)	3.25736801
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.25736801
8	Hyperglycinuria (HP:0003108)	3.15713013
9	Hyperactive renin-angiotensin system (HP:0000841)	3.12800239
10	Abnormality of proline metabolism (HP:0010907)	3.09064750
11	Hydroxyprolinuria (HP:0003080)	3.09064750
12	Type II lissencephaly (HP:0007260)	3.02576298
13	Molar tooth sign on MRI (HP:0002419)	3.00930924
14	Abnormality of midbrain morphology (HP:0002418)	3.00930924
15	Pancreatic cysts (HP:0001737)	2.99588987
16	Fat malabsorption (HP:0002630)	2.94220044
17	Abnormality of urine glucose concentration (HP:0011016)	2.89408276
18	Glycosuria (HP:0003076)	2.89408276
19	Abnormality of renin-angiotensin system (HP:0000847)	2.85546406
20	Tubular atrophy (HP:0000092)	2.82304116
21	Intrahepatic cholestasis (HP:0001406)	2.80995223
22	Abnormality of glycine metabolism (HP:0010895)	2.79727215
23	Abnormality of serine family amino acid metabolism (HP:0010894)	2.79727215
24	Abnormal respiratory epithelium morphology (HP:0012253)	2.69112653
25	Abnormal respiratory motile cilium morphology (HP:0005938)	2.69112653
26	Chronic hepatic failure (HP:0100626)	2.68622988
27	Alkalosis (HP:0001948)	2.63053118
28	Congenital stationary night blindness (HP:0007642)	2.59395575
29	Hypobetalipoproteinemia (HP:0003563)	2.56013997
30	Abnormal ciliary motility (HP:0012262)	2.55508947
31	Pancreatic fibrosis (HP:0100732)	2.48063415
32	Conjugated hyperbilirubinemia (HP:0002908)	2.46598027
33	Steatorrhea (HP:0002570)	2.46410450
34	Nephronophthisis (HP:0000090)	2.45153357
35	Abnormality of the renal medulla (HP:0100957)	2.45094223
36	Congenital sensorineural hearing impairment (HP:0008527)	2.44625609
37	Pigmentary retinal degeneration (HP:0001146)	2.44300669
38	Renal cortical cysts (HP:0000803)	2.43939165
39	Metabolic alkalosis (HP:0200114)	2.43798200
40	Ketosis (HP:0001946)	2.43431411
41	Delayed CNS myelination (HP:0002188)	2.41212513
42	Bile duct proliferation (HP:0001408)	2.39710491
43	Abnormal biliary tract physiology (HP:0012439)	2.39710491
44	Hyperammonemia (HP:0001987)	2.35914137
45	Attenuation of retinal blood vessels (HP:0007843)	2.31815946
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.30293201
47	Abolished electroretinogram (ERG) (HP:0000550)	2.29959008
48	Stomach cancer (HP:0012126)	2.29744885
49	Abnormality of vitamin B metabolism (HP:0004340)	2.27295337
50	True hermaphroditism (HP:0010459)	2.27172145
51	Hyperaldosteronism (HP:0000859)	2.26609724
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.26386799
53	Decreased central vision (HP:0007663)	2.25715371
54	Abnormal respiratory motile cilium physiology (HP:0012261)	2.24537320
55	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.23826605
56	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.23105228
57	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.22529204
58	Abnormal drinking behavior (HP:0030082)	2.20834981
59	Polydipsia (HP:0001959)	2.20834981
60	Tubulointerstitial nephritis (HP:0001970)	2.16609178
61	Abnormality of vitamin metabolism (HP:0100508)	2.11318084
62	Proximal tubulopathy (HP:0000114)	2.07833702
63	Abnormality of alanine metabolism (HP:0010916)	2.05565961
64	Hyperalaninemia (HP:0003348)	2.05565961
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05565961
66	Medial flaring of the eyebrow (HP:0010747)	2.04356602
67	Cerebellar dysplasia (HP:0007033)	2.04158944
68	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.01574756
69	Lethargy (HP:0001254)	2.00837994
70	Metabolic acidosis (HP:0001942)	2.00678022
71	Generalized aminoaciduria (HP:0002909)	2.00567505
72	Abnormality of renal excretion (HP:0011036)	2.00506396
73	Hyperglycinemia (HP:0002154)	2.00070116
74	Amelogenesis imperfecta (HP:0000705)	1.99920825
75	Ketoacidosis (HP:0001993)	1.99778191
76	Prolonged partial thromboplastin time (HP:0003645)	1.99607515
77	Azoospermia (HP:0000027)	1.97010927
78	Large for gestational age (HP:0001520)	1.96547038
79	Flat capital femoral epiphysis (HP:0003370)	1.93775197
80	Chronic bronchitis (HP:0004469)	1.91647785
81	Hyperphosphaturia (HP:0003109)	1.91265476
82	Cystic liver disease (HP:0006706)	1.90900421
83	Rhinitis (HP:0012384)	1.90421512
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.89574286
85	Hepatic necrosis (HP:0002605)	1.87565896
86	Tongue fasciculations (HP:0001308)	1.82891210
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82464063
88	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.81374169
89	Oligomenorrhea (HP:0000876)	1.80406313
90	Abnormality of chloride homeostasis (HP:0011422)	1.77429294
91	Polyuria (HP:0000103)	1.77044337
92	Abnormality of serum amino acid levels (HP:0003112)	1.76811007
93	Abnormality of pyrimidine metabolism (HP:0004353)	1.76784174
94	Cerebral palsy (HP:0100021)	1.74915315
95	Fair hair (HP:0002286)	1.74511529
96	Abnormal urine output (HP:0012590)	1.74474039
97	Breast carcinoma (HP:0003002)	1.73227103
98	Widely patent fontanelles and sutures (HP:0004492)	1.70739201
99	Severe muscular hypotonia (HP:0006829)	1.70270764
100	Dicarboxylic aciduria (HP:0003215)	1.70155796

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.14452469
2	ACVR1B	3.80589737
3	EPHA2	3.42684089
4	BMPR1B	3.25875713
5	TAOK3	2.82467449
6	MAPKAPK3	2.75168742
7	PINK1	2.74104617
8	ADRBK2	2.41149840
9	PIK3CA	2.37266888
10	MST4	2.36900719
11	STK39	2.32771332
12	GRK1	2.29892674
13	TLK1	2.22969863
14	MUSK	2.21037598
15	WNK4	2.19399414
16	MST1R	2.16272457
17	WNK3	2.02855288
18	OXSR1	2.00503819
19	ZAK	1.88870765
20	NUAK1	1.82142174
21	FER	1.77829371
22	LMTK2	1.72012722
23	MET	1.56461132
24	MAP4K2	1.51555165
25	MAP3K12	1.46036037
26	PRKCI	1.41124209
27	STK38L	1.35242770
28	EPHA3	1.20045787
29	IRAK1	1.19204093
30	DAPK2	1.13947526
31	MAP2K6	1.12269900
32	TXK	1.08815944
33	TRIM28	1.03726280
34	BCKDK	1.01541531
35	NEK6	0.98965454
36	CDK8	0.94169168
37	MAP2K2	0.93332342
38	MAPK15	0.91953918
39	CASK	0.91912094
40	INSRR	0.91730457
41	MAPK13	0.90436982
42	TGFBR1	0.89650177
43	GRK6	0.89011426
44	BRSK2	0.88883322
45	PRKCE	0.87498658
46	ERBB3	0.86711502
47	LATS1	0.84996468
48	BCR	0.84489388
49	PRKAA2	0.83425963
50	MAP2K1	0.82982295
51	ADRBK1	0.82365836
52	RPS6KB2	0.80911486
53	EIF2AK3	0.80780810
54	MAP3K4	0.79730179
55	PDK2	0.72501973
56	PRKG2	0.72094833
57	LIMK1	0.71746554
58	CHUK	0.69641503
59	PTK2B	0.69508527
60	CAMK2D	0.66864073
61	MAPKAPK5	0.66771997
62	TESK2	0.66048763
63	STK3	0.64343334
64	ERBB2	0.62892606
65	IKBKB	0.57358812
66	EIF2AK1	0.56347479
67	FGFR2	0.55738262
68	TNIK	0.54702967
69	TIE1	0.54124535
70	CSNK1A1	0.52986074
71	PHKG1	0.52114090
72	PHKG2	0.52114090
73	DYRK2	0.51416787
74	PRKCA	0.48888547
75	PAK3	0.48668394
76	IGF1R	0.47201653
77	MAP2K7	0.44657832
78	PRKCZ	0.44553060
79	PRKCQ	0.42587759
80	NME1	0.40365005
81	PRKACA	0.37405619
82	KIT	0.35029243
83	TESK1	0.33937658
84	MAP3K9	0.33523286
85	PRKAA1	0.31681108
86	EPHB2	0.29823050
87	MATK	0.29771881
88	CAMK2A	0.29322509
89	ABL2	0.28393828
90	RPS6KA5	0.27758556
91	PTK6	0.26131545
92	PRKACG	0.25276524
93	PLK1	0.24685691
94	SCYL2	0.24187798
95	MAP2K4	0.23986824
96	CSNK1D	0.23332951
97	PRKCG	0.23324120
98	CSNK1E	0.23211469
99	PRKG1	0.22081129
100	CSNK1G3	0.20887837

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.84712515
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.08339754
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.92668286
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.74996965
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.71091564
6	Chemical carcinogenesis_Homo sapiens_hsa05204	2.60286252
7	Fat digestion and absorption_Homo sapiens_hsa04975	2.51771646
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.41055101
9	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.39580719
10	Retinol metabolism_Homo sapiens_hsa00830	2.39536129
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.39302939
12	Sulfur metabolism_Homo sapiens_hsa00920	2.37697120
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.26463575
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.20974951
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.20861863
16	Nitrogen metabolism_Homo sapiens_hsa00910	2.19301017
17	Butanoate metabolism_Homo sapiens_hsa00650	2.07139874
18	Tryptophan metabolism_Homo sapiens_hsa00380	2.04030521
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.96807917
20	Histidine metabolism_Homo sapiens_hsa00340	1.90884476
21	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.90102330
22	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.86100412
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84896502
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81572066
25	Arginine biosynthesis_Homo sapiens_hsa00220	1.75210947
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69023224
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68117821
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.62186319
29	Fatty acid degradation_Homo sapiens_hsa00071	1.61871873
30	Peroxisome_Homo sapiens_hsa04146	1.51397356
31	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.46517388
32	Mineral absorption_Homo sapiens_hsa04978	1.42031202
33	ABC transporters_Homo sapiens_hsa02010	1.38885009
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37275728
35	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.31701050
36	Bile secretion_Homo sapiens_hsa04976	1.30905120
37	Propanoate metabolism_Homo sapiens_hsa00640	1.29416615
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22314859
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.19865893
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.15636771
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10242353
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.07997786
43	PPAR signaling pathway_Homo sapiens_hsa03320	1.06941248
44	Phototransduction_Homo sapiens_hsa04744	1.06429347
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.03625151
46	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03211123
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.98965525
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98925175
49	Pancreatic secretion_Homo sapiens_hsa04972	0.97331141
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.96148284
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94451309
52	Phenylalanine metabolism_Homo sapiens_hsa00360	0.94273338
53	Sulfur relay system_Homo sapiens_hsa04122	0.91016771
54	Glutathione metabolism_Homo sapiens_hsa00480	0.88092675
55	Protein export_Homo sapiens_hsa03060	0.86420434
56	Complement and coagulation cascades_Homo sapiens_hsa04610	0.85268170
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.80796599
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.80243403
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80137401
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.77294159
61	Fatty acid elongation_Homo sapiens_hsa00062	0.74346320
62	Metabolic pathways_Homo sapiens_hsa01100	0.73548222
63	Renin-angiotensin system_Homo sapiens_hsa04614	0.72730146
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69776340
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68658198
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.66916123
67	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.63910871
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62836171
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59704322
70	Protein digestion and absorption_Homo sapiens_hsa04974	0.59133618
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.58370558
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.47755042
73	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.39483060
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38908184
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.37676042
76	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.36198103
77	Circadian rhythm_Homo sapiens_hsa04710	0.35461641
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.34555804
79	One carbon pool by folate_Homo sapiens_hsa00670	0.33425199
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33330627
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33319372
82	Parkinsons disease_Homo sapiens_hsa05012	0.32134418
83	Huntingtons disease_Homo sapiens_hsa05016	0.30496243
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30043454
85	Folate biosynthesis_Homo sapiens_hsa00790	0.27017410
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26623000
87	Basal transcription factors_Homo sapiens_hsa03022	0.25077701
88	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.23945626
89	Serotonergic synapse_Homo sapiens_hsa04726	0.22373016
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.21629937
91	Taste transduction_Homo sapiens_hsa04742	0.21586384
92	Regulation of autophagy_Homo sapiens_hsa04140	0.21143780
93	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.19162936
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.16048438
95	Proteasome_Homo sapiens_hsa03050	0.14733308
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.13200058
97	Tight junction_Homo sapiens_hsa04530	0.11877677
98	Galactose metabolism_Homo sapiens_hsa00052	0.10592006
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.09664484
100	Homologous recombination_Homo sapiens_hsa03440	0.09348371

C4ORF19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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