C4ORF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.07709148
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.78954122
3epithelial cilium movement (GO:0003351)7.49156585
4cilium movement (GO:0003341)7.39733906
5cilium or flagellum-dependent cell motility (GO:0001539)7.05740926
6axoneme assembly (GO:0035082)5.78542651
7motile cilium assembly (GO:0044458)5.30526287
8regulation of cilium movement (GO:0003352)5.29015666
9behavioral response to nicotine (GO:0035095)4.45985585
10intraciliary transport (GO:0042073)4.23722176
11cilium organization (GO:0044782)4.21435591
12cilium assembly (GO:0042384)4.07064218
13cilium morphogenesis (GO:0060271)3.81821604
14fucose catabolic process (GO:0019317)3.62600349
15L-fucose metabolic process (GO:0042354)3.62600349
16L-fucose catabolic process (GO:0042355)3.62600349
17centriole replication (GO:0007099)3.52765645
18protein complex biogenesis (GO:0070271)3.49296367
19response to pheromone (GO:0019236)3.49281329
20ATP synthesis coupled proton transport (GO:0015986)3.48668091
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.48668091
22nonmotile primary cilium assembly (GO:0035058)3.48250745
23protein-cofactor linkage (GO:0018065)3.46868897
24protein localization to cilium (GO:0061512)3.45709148
25water-soluble vitamin biosynthetic process (GO:0042364)3.43321991
26regulation of microtubule-based movement (GO:0060632)3.42851820
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40151476
28left/right axis specification (GO:0070986)3.38274221
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.37105001
30NADH dehydrogenase complex assembly (GO:0010257)3.37105001
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37105001
32cellular ketone body metabolic process (GO:0046950)3.34918044
33protein polyglutamylation (GO:0018095)3.29500605
34mitochondrial respiratory chain complex assembly (GO:0033108)3.23607994
35left/right pattern formation (GO:0060972)3.20779411
36indolalkylamine metabolic process (GO:0006586)3.18603172
37retinal cone cell development (GO:0046549)3.17810777
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15337875
39cellular component assembly involved in morphogenesis (GO:0010927)3.14172674
40ketone body metabolic process (GO:1902224)3.13245934
41photoreceptor cell maintenance (GO:0045494)3.12206851
42DNA deamination (GO:0045006)3.10107575
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09568154
44platelet dense granule organization (GO:0060155)3.06188984
45sperm motility (GO:0030317)3.05898440
46determination of left/right symmetry (GO:0007368)3.04045672
47respiratory chain complex IV assembly (GO:0008535)2.99699480
48smoothened signaling pathway (GO:0007224)2.98955580
49electron transport chain (GO:0022900)2.96566386
50microtubule bundle formation (GO:0001578)2.94416235
51gamma-aminobutyric acid transport (GO:0015812)2.94158886
52chaperone-mediated protein transport (GO:0072321)2.92661787
53respiratory electron transport chain (GO:0022904)2.87799436
54determination of bilateral symmetry (GO:0009855)2.84914698
55detection of light stimulus involved in visual perception (GO:0050908)2.81733513
56detection of light stimulus involved in sensory perception (GO:0050962)2.81733513
57multicellular organism reproduction (GO:0032504)2.80453218
58centriole assembly (GO:0098534)2.79569968
59kidney morphogenesis (GO:0060993)2.76927068
60specification of symmetry (GO:0009799)2.76490897
61nucleoside diphosphate phosphorylation (GO:0006165)2.76321849
62neural tube formation (GO:0001841)2.73335029
63piRNA metabolic process (GO:0034587)2.71994447
64urinary tract smooth muscle contraction (GO:0014848)2.70500545
65indole-containing compound catabolic process (GO:0042436)2.67662853
66indolalkylamine catabolic process (GO:0046218)2.67662853
67tryptophan catabolic process (GO:0006569)2.67662853
68hydrogen ion transmembrane transport (GO:1902600)2.66366357
69proton transport (GO:0015992)2.65821425
70negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64202551
71establishment of protein localization to mitochondrial membrane (GO:0090151)2.62083806
72neuronal action potential (GO:0019228)2.61011977
73hydrogen transport (GO:0006818)2.59722112
74primary amino compound metabolic process (GO:1901160)2.58727769
75cytochrome complex assembly (GO:0017004)2.58355742
76lateral ventricle development (GO:0021670)2.58133288
77photoreceptor cell development (GO:0042461)2.56603680
78neurofilament cytoskeleton organization (GO:0060052)2.55746839
79otic vesicle formation (GO:0030916)2.54748690
80tryptophan metabolic process (GO:0006568)2.51885749
81spinal cord motor neuron differentiation (GO:0021522)2.51519091
82ventricular system development (GO:0021591)2.51292134
83protein neddylation (GO:0045116)2.49255905
84inner ear receptor stereocilium organization (GO:0060122)2.48441446
85indole-containing compound metabolic process (GO:0042430)2.48081030
86cornea development in camera-type eye (GO:0061303)2.46935158
87cell projection assembly (GO:0030031)2.45997940
88GTP biosynthetic process (GO:0006183)2.43073781
89behavioral response to ethanol (GO:0048149)2.42908985
90serotonin metabolic process (GO:0042428)2.42398741
91positive regulation of fatty acid transport (GO:2000193)2.40282954
92ubiquinone biosynthetic process (GO:0006744)2.40259561
93lateral sprouting from an epithelium (GO:0060601)2.39595946
94preassembly of GPI anchor in ER membrane (GO:0016254)2.38264502
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36596500
96positive regulation of meiosis (GO:0045836)2.34903410
97mannosylation (GO:0097502)2.34319628
98microtubule-based movement (GO:0007018)2.34242398
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.34139263
100negative regulation of T cell differentiation in thymus (GO:0033085)2.33314410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.29871957
2VDR_22108803_ChIP-Seq_LS180_Human2.98430366
3EZH2_22144423_ChIP-Seq_EOC_Human2.75242288
4GBX2_23144817_ChIP-Seq_PC3_Human2.66929449
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55280784
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46816122
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31886795
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.18350932
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15344690
10FUS_26573619_Chip-Seq_HEK293_Human2.14563878
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08879082
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07255701
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04070146
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04005709
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02143361
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00390792
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93157021
18EWS_26573619_Chip-Seq_HEK293_Human1.92502586
19P300_19829295_ChIP-Seq_ESCs_Human1.90813609
20IGF1R_20145208_ChIP-Seq_DFB_Human1.89236639
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.77949183
22TAF15_26573619_Chip-Seq_HEK293_Human1.76299234
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68505052
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.67697561
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66904740
26ER_23166858_ChIP-Seq_MCF-7_Human1.64454913
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61034478
28BCAT_22108803_ChIP-Seq_LS180_Human1.56083296
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54346325
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.53666248
31* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52665827
32NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50683182
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50283499
34SMAD4_21799915_ChIP-Seq_A2780_Human1.50161842
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49527224
36CBP_20019798_ChIP-Seq_JUKART_Human1.46276724
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46276724
38TP53_22573176_ChIP-Seq_HFKS_Human1.43184100
39STAT3_23295773_ChIP-Seq_U87_Human1.42756964
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42429397
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42277050
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40663284
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.40321969
44AR_25329375_ChIP-Seq_VCAP_Human1.39972182
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39934982
46REST_21632747_ChIP-Seq_MESCs_Mouse1.39673447
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39335936
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39192767
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.36762440
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36589996
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.36342980
52NANOG_19829295_ChIP-Seq_ESCs_Human1.34517721
53SOX2_19829295_ChIP-Seq_ESCs_Human1.34517721
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.33721943
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33721943
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32379713
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30839335
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.29585136
59TCF4_22108803_ChIP-Seq_LS180_Human1.28850176
60RNF2_27304074_Chip-Seq_NSC_Mouse1.27836999
61* TCF4_23295773_ChIP-Seq_U87_Human1.27056555
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26494352
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.26376737
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26306199
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24375731
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23950691
67AR_21572438_ChIP-Seq_LNCaP_Human1.20273588
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20181329
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20181329
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20164328
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.19859554
72* RUNX2_22187159_ChIP-Seq_PCA_Human1.16833868
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16476474
74ELK1_19687146_ChIP-ChIP_HELA_Human1.16475054
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15544510
76NCOR_22424771_ChIP-Seq_293T_Human1.14518413
77AR_20517297_ChIP-Seq_VCAP_Human1.12419254
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11630300
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.11171838
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10942996
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10706197
82P53_22387025_ChIP-Seq_ESCs_Mouse1.10306841
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.10237533
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09956739
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.09942025
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.09701703
87ETV1_20927104_ChIP-Seq_GIST48_Human1.08713457
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08363021
89CDX2_22108803_ChIP-Seq_LS180_Human1.07534344
90IRF1_19129219_ChIP-ChIP_H3396_Human1.06988146
91PHF8_20622853_ChIP-Seq_HELA_Human1.05120665
92VDR_23849224_ChIP-Seq_CD4+_Human1.04211524
93MYC_18940864_ChIP-ChIP_HL60_Human1.00663054
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00562801
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.99984182
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98868981
97TBL1_22424771_ChIP-Seq_293T_Human0.98591928
98MYC_19829295_ChIP-Seq_ESCs_Human0.97631601
99RBPJ_21746931_ChIP-Seq_IB4_Human0.96628453
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.96494754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.18860378
2MP0003136_yellow_coat_color3.12257888
3MP0002653_abnormal_ependyma_morphology2.79128982
4MP0002638_abnormal_pupillary_reflex2.70207213
5MP0006072_abnormal_retinal_apoptosis2.52585831
6MP0004133_heterotaxia2.52203313
7MP0003011_delayed_dark_adaptation2.31650717
8MP0008875_abnormal_xenobiotic_pharmacok2.28374743
9MP0005551_abnormal_eye_electrophysiolog2.24520793
10MP0002837_dystrophic_cardiac_calcinosis2.13959570
11MP0001984_abnormal_olfaction2.08608624
12MP0003195_calcinosis2.08062107
13MP0004142_abnormal_muscle_tone2.02582316
14MP0009745_abnormal_behavioral_response1.97232243
15MP0005253_abnormal_eye_physiology1.97207502
16MP0001485_abnormal_pinna_reflex1.93431339
17MP0002938_white_spotting1.91994593
18MP0008877_abnormal_DNA_methylation1.89643927
19MP0004885_abnormal_endolymph1.85397958
20MP0000372_irregular_coat_pigmentation1.81886868
21MP0001968_abnormal_touch/_nociception1.79524026
22MP0002272_abnormal_nervous_system1.77550452
23MP0004043_abnormal_pH_regulation1.71273832
24MP0002876_abnormal_thyroid_physiology1.70866419
25MP0009046_muscle_twitch1.70584951
26MP0005645_abnormal_hypothalamus_physiol1.68182810
27MP0002277_abnormal_respiratory_mucosa1.64366515
28MP0005646_abnormal_pituitary_gland1.52767594
29MP0008872_abnormal_physiological_respon1.52627023
30MP0001486_abnormal_startle_reflex1.51615865
31MP0005084_abnormal_gallbladder_morpholo1.51607636
32MP0001529_abnormal_vocalization1.51209396
33MP0000631_abnormal_neuroendocrine_gland1.50032874
34MP0003878_abnormal_ear_physiology1.49921482
35MP0005377_hearing/vestibular/ear_phenot1.49921482
36MP0004742_abnormal_vestibular_system1.47424238
37MP0002735_abnormal_chemical_nociception1.45613238
38MP0001970_abnormal_pain_threshold1.37429187
39MP0002160_abnormal_reproductive_system1.37341532
40MP0002572_abnormal_emotion/affect_behav1.36566498
41MP0002064_seizures1.33403922
42MP0005379_endocrine/exocrine_gland_phen1.30844513
43MP0000569_abnormal_digit_pigmentation1.29865286
44MP0003283_abnormal_digestive_organ1.29589629
45MP0006276_abnormal_autonomic_nervous1.28905142
46MP0002734_abnormal_mechanical_nocicepti1.28900830
47MP0001905_abnormal_dopamine_level1.28648299
48MP0001986_abnormal_taste_sensitivity1.28569039
49MP0003880_abnormal_central_pattern1.25852429
50MP0004147_increased_porphyrin_level1.23700921
51MP0002733_abnormal_thermal_nociception1.22573203
52MP0002928_abnormal_bile_duct1.22565007
53MP0002163_abnormal_gland_morphology1.19671978
54MP0005410_abnormal_fertilization1.19638120
55MP0005389_reproductive_system_phenotype1.19438135
56MP0001501_abnormal_sleep_pattern1.18928515
57MP0002557_abnormal_social/conspecific_i1.18360771
58MP0003646_muscle_fatigue1.17690910
59MP0000383_abnormal_hair_follicle1.17196542
60MP0002736_abnormal_nociception_after1.15766872
61MP0010386_abnormal_urinary_bladder1.10174381
62MP0006292_abnormal_olfactory_placode1.08891864
63MP0005195_abnormal_posterior_eye1.08433312
64MP0005075_abnormal_melanosome_morpholog1.08425484
65MP0004019_abnormal_vitamin_homeostasis1.07230898
66MP0000026_abnormal_inner_ear1.06968360
67MP0003787_abnormal_imprinting1.05961571
68MP0002909_abnormal_adrenal_gland1.05226775
69MP0005085_abnormal_gallbladder_physiolo1.02133360
70MP0000427_abnormal_hair_cycle1.02113086
71MP0002067_abnormal_sensory_capabilities1.01669910
72MP0003698_abnormal_male_reproductive1.01011269
73MP0000566_synostosis1.00947984
74MP0003718_maternal_effect1.00777978
75MP0002282_abnormal_trachea_morphology1.00460156
76MP0002184_abnormal_innervation0.95421493
77MP0004215_abnormal_myocardial_fiber0.94452024
78MP0002752_abnormal_somatic_nervous0.94449571
79MP0008995_early_reproductive_senescence0.93960072
80MP0005174_abnormal_tail_pigmentation0.93498053
81MP0001929_abnormal_gametogenesis0.91021710
82MP0009780_abnormal_chondrocyte_physiolo0.90819226
83MP0002063_abnormal_learning/memory/cond0.90642478
84MP0003635_abnormal_synaptic_transmissio0.90499444
85MP0001919_abnormal_reproductive_system0.90095141
86MP0004924_abnormal_behavior0.89992158
87MP0005386_behavior/neurological_phenoty0.89992158
88MP0002234_abnormal_pharynx_morphology0.89015624
89MP0003937_abnormal_limbs/digits/tail_de0.88400321
90MP0008789_abnormal_olfactory_epithelium0.88370112
91MP0002751_abnormal_autonomic_nervous0.85330604
92MP0001324_abnormal_eye_pigmentation0.85276270
93MP0001963_abnormal_hearing_physiology0.84289115
94MP0002229_neurodegeneration0.82743472
95MP0002210_abnormal_sex_determination0.82173437
96MP0001944_abnormal_pancreas_morphology0.82141483
97MP0005332_abnormal_amino_acid0.81729682
98MP0005391_vision/eye_phenotype0.79552566
99MP0002095_abnormal_skin_pigmentation0.79084563
100MP0005636_abnormal_mineral_homeostasis0.78806778

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.31781330
2Absent/shortened dynein arms (HP:0200106)6.31781330
3Abnormal respiratory epithelium morphology (HP:0012253)6.08711650
4Abnormal respiratory motile cilium morphology (HP:0005938)6.08711650
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.90564015
6Abnormal ciliary motility (HP:0012262)5.89932152
7Abnormal respiratory motile cilium physiology (HP:0012261)5.65696269
8Rhinitis (HP:0012384)4.75188616
9Pancreatic cysts (HP:0001737)4.68874203
10Pancreatic fibrosis (HP:0100732)4.66046734
11Abnormality of midbrain morphology (HP:0002418)4.46087383
12Molar tooth sign on MRI (HP:0002419)4.46087383
13True hermaphroditism (HP:0010459)4.45232158
14Nephronophthisis (HP:0000090)3.82767059
15Medial flaring of the eyebrow (HP:0010747)3.82143311
16Bronchiectasis (HP:0002110)3.62499004
17Chronic bronchitis (HP:0004469)3.40037227
18Cystic liver disease (HP:0006706)3.17522591
19Abnormality of the renal medulla (HP:0100957)3.17468930
20Abnormality of the renal cortex (HP:0011035)3.12083664
21Gait imbalance (HP:0002141)2.99527010
22Congenital primary aphakia (HP:0007707)2.89437663
23Occipital encephalocele (HP:0002085)2.86935729
24Congenital stationary night blindness (HP:0007642)2.83829834
25Tubular atrophy (HP:0000092)2.79106437
26Chronic hepatic failure (HP:0100626)2.78989359
27Type II lissencephaly (HP:0007260)2.66003904
28Nephrogenic diabetes insipidus (HP:0009806)2.62790315
29Hypothermia (HP:0002045)2.61920085
30Tubulointerstitial nephritis (HP:0001970)2.60250228
31Abnormal rod and cone electroretinograms (HP:0008323)2.60146828
32Polydipsia (HP:0001959)2.54531582
33Abnormal drinking behavior (HP:0030082)2.54531582
34Mitochondrial inheritance (HP:0001427)2.50364734
35Congenital hepatic fibrosis (HP:0002612)2.49418717
36Sclerocornea (HP:0000647)2.49266365
37Abnormal biliary tract physiology (HP:0012439)2.47090503
38Bile duct proliferation (HP:0001408)2.47090503
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.46576292
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43317908
41Genital tract atresia (HP:0001827)2.43196791
42Postaxial foot polydactyly (HP:0001830)2.41188938
43Anencephaly (HP:0002323)2.40252961
44Increased CSF lactate (HP:0002490)2.38772868
45Increased hepatocellular lipid droplets (HP:0006565)2.38694063
463-Methylglutaconic aciduria (HP:0003535)2.37196767
47Acute necrotizing encephalopathy (HP:0006965)2.34862020
48Vaginal atresia (HP:0000148)2.32042458
49Lipid accumulation in hepatocytes (HP:0006561)2.28645853
50Hepatocellular necrosis (HP:0001404)2.24249075
51Male pseudohermaphroditism (HP:0000037)2.23417966
52Renal cortical cysts (HP:0000803)2.22345178
53Postaxial hand polydactyly (HP:0001162)2.20664830
54Infertility (HP:0000789)2.20058248
55Hepatic necrosis (HP:0002605)2.18788752
56Furrowed tongue (HP:0000221)2.17975644
57Renal Fanconi syndrome (HP:0001994)2.16791494
58Decreased circulating renin level (HP:0003351)2.16106999
59Progressive macrocephaly (HP:0004481)2.14521575
60Abolished electroretinogram (ERG) (HP:0000550)2.12457590
61Large for gestational age (HP:0001520)2.08196049
62Acute encephalopathy (HP:0006846)2.05394253
63Nasal polyposis (HP:0100582)2.05300590
64Abnormal mitochondria in muscle tissue (HP:0008316)1.98991029
65Oculomotor apraxia (HP:0000657)1.98682700
66Congenital, generalized hypertrichosis (HP:0004540)1.95128440
67Tubulointerstitial abnormality (HP:0001969)1.93334811
68Hyperventilation (HP:0002883)1.91614736
69Poor coordination (HP:0002370)1.90920787
70Polyuria (HP:0000103)1.90333128
71Chronic sinusitis (HP:0011109)1.90147533
72Cerebellar dysplasia (HP:0007033)1.89280248
73Decreased central vision (HP:0007663)1.85595589
74Preaxial hand polydactyly (HP:0001177)1.85438602
75Methylmalonic acidemia (HP:0002912)1.84198696
76Bony spicule pigmentary retinopathy (HP:0007737)1.84129947
77Recurrent sinusitis (HP:0011108)1.77880994
78Attenuation of retinal blood vessels (HP:0007843)1.74283064
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.74173912
80Hyperglycinemia (HP:0002154)1.69543385
81Bronchitis (HP:0012387)1.67743379
82Hemiparesis (HP:0001269)1.66962840
83Abnormality of macular pigmentation (HP:0008002)1.66920529
84Optic disc pallor (HP:0000543)1.66909792
85Retinitis pigmentosa (HP:0000510)1.66608958
86Supernumerary spleens (HP:0009799)1.66496456
87Asplenia (HP:0001746)1.63431328
88Lissencephaly (HP:0001339)1.63404906
89Abnormal number of erythroid precursors (HP:0012131)1.63109864
90Anophthalmia (HP:0000528)1.61948505
91Aplasia/hypoplasia of the uterus (HP:0008684)1.58740815
92Narrow forehead (HP:0000341)1.57937495
93Methylmalonic aciduria (HP:0012120)1.57708036
94Abnormality of renal resorption (HP:0011038)1.57461290
95Limb dystonia (HP:0002451)1.56801140
96Aganglionic megacolon (HP:0002251)1.55698435
97Increased serum lactate (HP:0002151)1.55551177
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.53497346
99Abnormality of alanine metabolism (HP:0010916)1.53497346
100Hyperalaninemia (HP:0003348)1.53497346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.45934927
2MAPK153.60347749
3BMPR1B3.57591699
4ADRBK23.02339434
5WNK32.82137909
6WNK42.43651310
7MAP4K22.35854835
8GRK12.25648067
9ZAK2.24362140
10TLK12.20810865
11PINK12.16746700
12CASK2.12387880
13STK392.07316044
14MST42.00783499
15NUAK11.89564278
16INSRR1.89463586
17TAOK31.82826538
18MAP3K41.82264056
19PNCK1.76830549
20OXSR11.52730236
21STK161.49694303
22MAPK131.49335291
23MUSK1.46703781
24TGFBR11.41226493
25MARK11.38789581
26VRK11.36002780
27CDK81.33425974
28DYRK21.28522537
29PRKCG1.24093526
30MAP2K61.20186308
31PLK41.15952212
32PRKCE1.13315418
33NME11.11672464
34PHKG11.11141531
35PHKG21.11141531
36TNIK1.09863655
37EPHA31.09181775
38PAK31.06982330
39ADRBK11.04390688
40TXK1.00393911
41MKNK21.00266989
42PTK2B0.98162537
43ACVR1B0.91657124
44NTRK30.91435078
45MAP2K70.87554175
46FGFR20.84104921
47TRIM280.80518566
48PASK0.79689531
49CSNK1G20.78267813
50BRSK20.78232228
51PRKCI0.76890658
52STK38L0.76650883
53PKN10.75920979
54DAPK20.72484559
55BCR0.72312194
56CSNK1G10.71100384
57TIE10.66689184
58CSNK1G30.66055284
59CAMK2A0.64504157
60MAPKAPK30.62935057
61PLK20.61922415
62STK30.60200052
63WEE10.60181226
64PLK30.58328376
65PRKACA0.55584734
66EIF2AK30.52472107
67MINK10.51003153
68CAMKK20.50893211
69VRK20.49673110
70BCKDK0.49610857
71PRKCQ0.49488821
72GRK70.47472011
73ERBB30.46018952
74MAPKAPK50.45563212
75PIK3CA0.44063105
76RPS6KA50.42867818
77PRKCA0.42236367
78CSNK1A10.41605518
79PDK20.41069080
80CSNK1A1L0.41033439
81CHEK20.40018482
82PRKCZ0.39678170
83AKT30.39521298
84TEC0.38133580
85PRKG10.35698069
86CDK30.34681997
87STK110.33600222
88DYRK1A0.32139150
89EPHA40.31912396
90NLK0.31889695
91CAMK10.30902131
92PRKACB0.29912939
93MKNK10.28567880
94OBSCN0.28304161
95CSNK1D0.28155435
96MAP3K120.27176293
97PLK10.26943151
98CDK90.26731768
99PRKCH0.24306896
100ERBB20.24254633

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.51903612
2Parkinsons disease_Homo sapiens_hsa050122.69024848
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50659099
4Huntingtons disease_Homo sapiens_hsa050162.46977335
5Phototransduction_Homo sapiens_hsa047442.36421964
6Protein export_Homo sapiens_hsa030602.33267689
7Butanoate metabolism_Homo sapiens_hsa006502.16688257
8Linoleic acid metabolism_Homo sapiens_hsa005912.16551124
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12104403
10Nitrogen metabolism_Homo sapiens_hsa009102.05498885
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03540667
12Nicotine addiction_Homo sapiens_hsa050332.00825903
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.99045540
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.91923881
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86884846
16RNA polymerase_Homo sapiens_hsa030201.86873913
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80761362
18Alzheimers disease_Homo sapiens_hsa050101.80640068
19Selenocompound metabolism_Homo sapiens_hsa004501.79643990
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75872119
21Cardiac muscle contraction_Homo sapiens_hsa042601.75633498
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72669970
23Basal transcription factors_Homo sapiens_hsa030221.69944083
24Caffeine metabolism_Homo sapiens_hsa002321.69048283
25Tryptophan metabolism_Homo sapiens_hsa003801.66819689
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66189498
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56364258
28Chemical carcinogenesis_Homo sapiens_hsa052041.53062469
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50115209
30Collecting duct acid secretion_Homo sapiens_hsa049661.47139813
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40488762
32Ribosome_Homo sapiens_hsa030101.38786506
33Homologous recombination_Homo sapiens_hsa034401.37484428
34Regulation of autophagy_Homo sapiens_hsa041401.31945684
35Peroxisome_Homo sapiens_hsa041461.30443200
36Histidine metabolism_Homo sapiens_hsa003401.28270376
37Propanoate metabolism_Homo sapiens_hsa006401.25504929
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23052467
39RNA degradation_Homo sapiens_hsa030181.23044119
40Olfactory transduction_Homo sapiens_hsa047401.22156678
41Proteasome_Homo sapiens_hsa030501.21232802
42Taste transduction_Homo sapiens_hsa047421.20878919
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.18340336
44Sulfur metabolism_Homo sapiens_hsa009201.18312827
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16182059
46Ether lipid metabolism_Homo sapiens_hsa005651.13058368
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.03749579
48beta-Alanine metabolism_Homo sapiens_hsa004101.02168859
49Fanconi anemia pathway_Homo sapiens_hsa034601.01555797
50One carbon pool by folate_Homo sapiens_hsa006700.99882504
51Retinol metabolism_Homo sapiens_hsa008300.99720655
52GABAergic synapse_Homo sapiens_hsa047270.96325606
53Arachidonic acid metabolism_Homo sapiens_hsa005900.92287185
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90356794
55Morphine addiction_Homo sapiens_hsa050320.88979114
56Serotonergic synapse_Homo sapiens_hsa047260.86848276
57ABC transporters_Homo sapiens_hsa020100.84350998
58Insulin secretion_Homo sapiens_hsa049110.82617766
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81726942
60Metabolic pathways_Homo sapiens_hsa011000.79975905
61Glutamatergic synapse_Homo sapiens_hsa047240.78554326
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77565174
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73166520
64Purine metabolism_Homo sapiens_hsa002300.72842571
65Tyrosine metabolism_Homo sapiens_hsa003500.67691761
66Circadian entrainment_Homo sapiens_hsa047130.66878362
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65848151
68Fatty acid degradation_Homo sapiens_hsa000710.65342177
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64217195
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63752180
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61928981
72Steroid biosynthesis_Homo sapiens_hsa001000.58682087
73Hedgehog signaling pathway_Homo sapiens_hsa043400.57263880
74Glutathione metabolism_Homo sapiens_hsa004800.56310444
75Fatty acid biosynthesis_Homo sapiens_hsa000610.55765863
76Folate biosynthesis_Homo sapiens_hsa007900.55679389
77Cocaine addiction_Homo sapiens_hsa050300.54703556
78Dorso-ventral axis formation_Homo sapiens_hsa043200.54145023
79Calcium signaling pathway_Homo sapiens_hsa040200.54077468
80Mineral absorption_Homo sapiens_hsa049780.52920751
81Pyrimidine metabolism_Homo sapiens_hsa002400.48926034
82Synaptic vesicle cycle_Homo sapiens_hsa047210.48195950
83Phenylalanine metabolism_Homo sapiens_hsa003600.45711870
84Salivary secretion_Homo sapiens_hsa049700.45531450
85Dopaminergic synapse_Homo sapiens_hsa047280.44633635
86Circadian rhythm_Homo sapiens_hsa047100.43273772
87Amphetamine addiction_Homo sapiens_hsa050310.42489368
88Basal cell carcinoma_Homo sapiens_hsa052170.40732804
89Ovarian steroidogenesis_Homo sapiens_hsa049130.40583601
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40232096
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40022960
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39119951
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.37789184
94Nucleotide excision repair_Homo sapiens_hsa034200.36878533
95Fat digestion and absorption_Homo sapiens_hsa049750.32091549
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31589500
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30822643
98Glycerolipid metabolism_Homo sapiens_hsa005610.30077775
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.27253388
100TGF-beta signaling pathway_Homo sapiens_hsa043500.26111769

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