C4ORF26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during amelogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.29595543
2protein K11-linked deubiquitination (GO:0035871)4.29078200
3response to pheromone (GO:0019236)4.20364154
4water-soluble vitamin biosynthetic process (GO:0042364)4.17077923
5L-fucose catabolic process (GO:0042355)4.04581472
6fucose catabolic process (GO:0019317)4.04581472
7L-fucose metabolic process (GO:0042354)4.04581472
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84096572
9protein complex biogenesis (GO:0070271)3.80310415
10platelet dense granule organization (GO:0060155)3.79315752
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.73966131
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.68742505
13NADH dehydrogenase complex assembly (GO:0010257)3.68742505
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68742505
15tryptophan catabolic process (GO:0006569)3.60441297
16indole-containing compound catabolic process (GO:0042436)3.60441297
17indolalkylamine catabolic process (GO:0046218)3.60441297
18negative regulation of telomere maintenance (GO:0032205)3.56323050
19DNA deamination (GO:0045006)3.52762240
20mitochondrial respiratory chain complex assembly (GO:0033108)3.49545177
21respiratory chain complex IV assembly (GO:0008535)3.49227558
22indolalkylamine metabolic process (GO:0006586)3.48459213
23kynurenine metabolic process (GO:0070189)3.42913975
24protein-cofactor linkage (GO:0018065)3.40577187
25epithelial cilium movement (GO:0003351)3.39353808
26axoneme assembly (GO:0035082)3.29251016
27piRNA metabolic process (GO:0034587)3.29071678
28preassembly of GPI anchor in ER membrane (GO:0016254)3.29062841
29cellular ketone body metabolic process (GO:0046950)3.28875589
30tryptophan metabolic process (GO:0006568)3.24188321
31regulation of cilium movement (GO:0003352)3.21021358
32nonmotile primary cilium assembly (GO:0035058)3.20896365
33somite development (GO:0061053)3.19300828
34cytochrome complex assembly (GO:0017004)3.18529525
35neural tube formation (GO:0001841)3.13354279
36ubiquinone biosynthetic process (GO:0006744)3.03961020
37ubiquinone metabolic process (GO:0006743)3.02912533
38retinal cone cell development (GO:0046549)3.01868685
39protein polyglutamylation (GO:0018095)2.96970334
40cilium morphogenesis (GO:0060271)2.95295927
41ketone body metabolic process (GO:1902224)2.94291033
42nephron tubule morphogenesis (GO:0072078)2.92644022
43nephron epithelium morphogenesis (GO:0072088)2.92644022
44negative regulation of mast cell activation (GO:0033004)2.92094722
45pyrimidine nucleobase catabolic process (GO:0006208)2.90247368
46regulation of hexokinase activity (GO:1903299)2.89432978
47regulation of glucokinase activity (GO:0033131)2.89432978
48DNA double-strand break processing (GO:0000729)2.84704889
49kidney morphogenesis (GO:0060993)2.82218847
50mannosylation (GO:0097502)2.80652365
51gamma-aminobutyric acid transport (GO:0015812)2.77416091
52neuronal action potential (GO:0019228)2.76433938
53sulfation (GO:0051923)2.75233514
54reflex (GO:0060004)2.74588664
55photoreceptor cell maintenance (GO:0045494)2.70324454
56cellular biogenic amine catabolic process (GO:0042402)2.69954540
57amine catabolic process (GO:0009310)2.69954540
58dopamine transport (GO:0015872)2.69942505
59indole-containing compound metabolic process (GO:0042430)2.69902403
60cilium organization (GO:0044782)2.68003037
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67951007
62detection of light stimulus involved in visual perception (GO:0050908)2.67021979
63detection of light stimulus involved in sensory perception (GO:0050962)2.67021979
64synaptic transmission, cholinergic (GO:0007271)2.65252020
65cilium assembly (GO:0042384)2.62367943
66cilium movement (GO:0003341)2.62094026
67photoreceptor cell development (GO:0042461)2.61741509
68negative regulation of DNA-dependent DNA replication (GO:2000104)2.61431788
69protein localization to cilium (GO:0061512)2.61343857
70positive regulation of oligodendrocyte differentiation (GO:0048714)2.61180882
71nucleobase catabolic process (GO:0046113)2.59342391
72protein K6-linked ubiquitination (GO:0085020)2.59332385
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57936539
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57936539
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57689695
76regulation of microtubule-based movement (GO:0060632)2.57666964
77phosphatidylinositol acyl-chain remodeling (GO:0036149)2.55905891
78cornea development in camera-type eye (GO:0061303)2.55219811
79regulation of action potential (GO:0098900)2.53406986
80C-terminal protein amino acid modification (GO:0018410)2.50226736
81positive regulation of mitochondrial fission (GO:0090141)2.49912399
82regulation of hippo signaling (GO:0035330)2.49767705
83DNA methylation involved in gamete generation (GO:0043046)2.49309974
84parturition (GO:0007567)2.49072894
85GPI anchor metabolic process (GO:0006505)2.47197183
86behavioral response to ethanol (GO:0048149)2.46616392
87replication fork processing (GO:0031297)2.45322754
88glycerophospholipid catabolic process (GO:0046475)2.45248312
89ATP synthesis coupled proton transport (GO:0015986)2.44914414
90energy coupled proton transport, down electrochemical gradient (GO:0015985)2.44914414
91auditory receptor cell stereocilium organization (GO:0060088)2.43818285
92limb bud formation (GO:0060174)2.43312723
93regulation of neurotransmitter uptake (GO:0051580)2.42527966
94regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41975105
95neuron fate determination (GO:0048664)2.41915702
96regulation of telomere maintenance (GO:0032204)2.41845418
97primary amino compound metabolic process (GO:1901160)2.41417647
98regulation of mesoderm development (GO:2000380)2.40638901
99rhodopsin mediated signaling pathway (GO:0016056)2.40338945
100S-adenosylmethionine metabolic process (GO:0046500)2.40292387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.24449614
2VDR_22108803_ChIP-Seq_LS180_Human3.15318731
3GBX2_23144817_ChIP-Seq_PC3_Human3.13632076
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88141072
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76900418
6EZH2_22144423_ChIP-Seq_EOC_Human2.68512930
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52530252
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36598297
9IGF1R_20145208_ChIP-Seq_DFB_Human2.30068636
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28820124
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.18088815
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11068522
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08500975
14EWS_26573619_Chip-Seq_HEK293_Human2.03745060
15TAF15_26573619_Chip-Seq_HEK293_Human1.97542018
16P300_19829295_ChIP-Seq_ESCs_Human1.97017126
17NOTCH1_21737748_ChIP-Seq_TLL_Human1.96018768
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.92058136
19FUS_26573619_Chip-Seq_HEK293_Human1.89426175
20ER_23166858_ChIP-Seq_MCF-7_Human1.87473352
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86577078
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83088439
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79586236
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77125989
25TP53_22573176_ChIP-Seq_HFKS_Human1.65446877
26BCAT_22108803_ChIP-Seq_LS180_Human1.60180953
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60170234
28IRF1_19129219_ChIP-ChIP_H3396_Human1.59312565
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.57809214
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.54667120
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.54416313
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50810211
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48549434
34REST_21632747_ChIP-Seq_MESCs_Mouse1.47664481
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47337916
36MYC_18940864_ChIP-ChIP_HL60_Human1.46385117
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44623715
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.44623715
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44461508
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42637452
41CBP_20019798_ChIP-Seq_JUKART_Human1.42637452
42AR_25329375_ChIP-Seq_VCAP_Human1.42175701
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.41385050
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39540337
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39254540
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39184999
47STAT3_23295773_ChIP-Seq_U87_Human1.36804477
48RNF2_27304074_Chip-Seq_NSC_Mouse1.34888062
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33829752
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.33715885
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32407972
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31451878
53* SOX2_19829295_ChIP-Seq_ESCs_Human1.31016858
54* NANOG_19829295_ChIP-Seq_ESCs_Human1.31016858
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30797593
56TCF4_23295773_ChIP-Seq_U87_Human1.29812270
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.29504652
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29252411
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28052073
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26549564
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24524389
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24166927
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.23911566
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23337906
65VDR_23849224_ChIP-Seq_CD4+_Human1.22562536
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21254214
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20947932
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20390808
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20254949
70NCOR_22424771_ChIP-Seq_293T_Human1.19811298
71TCF4_22108803_ChIP-Seq_LS180_Human1.19299319
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.18220283
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17489374
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.17460537
75AR_20517297_ChIP-Seq_VCAP_Human1.16308914
76ELK1_19687146_ChIP-ChIP_HELA_Human1.14640706
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12528464
78HOXB7_26014856_ChIP-Seq_BT474_Human1.12441997
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.11013264
80RUNX2_22187159_ChIP-Seq_PCA_Human1.10350731
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10275125
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10275125
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.09564939
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08050000
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05634613
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.05538448
87ERA_21632823_ChIP-Seq_H3396_Human1.03038706
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02676632
89MYC_19829295_ChIP-Seq_ESCs_Human1.02359733
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00209811
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99893373
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99360138
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.98839610
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98285533
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.97311323
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97231677
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.96871373
98P53_22387025_ChIP-Seq_ESCs_Mouse0.95876311
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.94931284
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.94926467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.15612229
2MP0003195_calcinosis2.82403615
3MP0002102_abnormal_ear_morphology2.74841208
4MP0005551_abnormal_eye_electrophysiolog2.52359331
5MP0000569_abnormal_digit_pigmentation2.43846936
6MP0003880_abnormal_central_pattern2.28898722
7MP0005084_abnormal_gallbladder_morpholo2.23439859
8MP0002837_dystrophic_cardiac_calcinosis2.19958808
9MP0002653_abnormal_ependyma_morphology2.19321153
10MP0006072_abnormal_retinal_apoptosis2.15178761
11MP0008875_abnormal_xenobiotic_pharmacok2.14513807
12MP0006292_abnormal_olfactory_placode2.01280643
13MP0005645_abnormal_hypothalamus_physiol1.97167428
14MP0009046_muscle_twitch1.94782210
15MP0002638_abnormal_pupillary_reflex1.92712743
16MP0003011_delayed_dark_adaptation1.92598497
17MP0001984_abnormal_olfaction1.90717712
18MP0001968_abnormal_touch/_nociception1.87996987
19MP0002876_abnormal_thyroid_physiology1.85509289
20MP0003136_yellow_coat_color1.84165023
21MP0008872_abnormal_physiological_respon1.83906173
22MP0004043_abnormal_pH_regulation1.79829048
23MP0004133_heterotaxia1.79292566
24MP0005253_abnormal_eye_physiology1.76123454
25MP0002938_white_spotting1.74016238
26MP0004142_abnormal_muscle_tone1.72869027
27MP0004885_abnormal_endolymph1.72544384
28MP0001529_abnormal_vocalization1.69232531
29MP0009745_abnormal_behavioral_response1.68098181
30MP0002272_abnormal_nervous_system1.62491821
31MP0000372_irregular_coat_pigmentation1.57939350
32MP0005646_abnormal_pituitary_gland1.57621645
33MP0004147_increased_porphyrin_level1.55972856
34MP0005174_abnormal_tail_pigmentation1.55173468
35MP0003787_abnormal_imprinting1.54495914
36MP0000383_abnormal_hair_follicle1.53750090
37MP0006276_abnormal_autonomic_nervous1.53122686
38MP0002736_abnormal_nociception_after1.51589386
39MP0001486_abnormal_startle_reflex1.51119403
40MP0000631_abnormal_neuroendocrine_gland1.50926984
41MP0001485_abnormal_pinna_reflex1.50878145
42MP0001986_abnormal_taste_sensitivity1.47982521
43MP0002234_abnormal_pharynx_morphology1.47077937
44MP0003646_muscle_fatigue1.45421821
45MP0002572_abnormal_emotion/affect_behav1.39594654
46MP0001501_abnormal_sleep_pattern1.37705789
47MP0000427_abnormal_hair_cycle1.35607457
48MP0002928_abnormal_bile_duct1.34129481
49MP0003283_abnormal_digestive_organ1.33756030
50MP0002138_abnormal_hepatobiliary_system1.33056884
51MP0004742_abnormal_vestibular_system1.24996328
52MP0002064_seizures1.24262766
53MP0002557_abnormal_social/conspecific_i1.21385410
54MP0002751_abnormal_autonomic_nervous1.18763364
55MP0001905_abnormal_dopamine_level1.17016896
56MP0005075_abnormal_melanosome_morpholog1.14199979
57MP0001970_abnormal_pain_threshold1.13876344
58MP0005195_abnormal_posterior_eye1.12678868
59MP0002067_abnormal_sensory_capabilities1.09684340
60MP0000026_abnormal_inner_ear1.08539078
61MP0003122_maternal_imprinting1.07653846
62MP0005389_reproductive_system_phenotype1.03839546
63MP0002733_abnormal_thermal_nociception1.02769187
64MP0000778_abnormal_nervous_system1.02682800
65MP0003878_abnormal_ear_physiology1.02078818
66MP0005377_hearing/vestibular/ear_phenot1.02078818
67MP0002735_abnormal_chemical_nociception1.01838071
68MP0008995_early_reproductive_senescence1.01341088
69MP0002095_abnormal_skin_pigmentation1.00900215
70MP0002160_abnormal_reproductive_system0.98196310
71MP0008789_abnormal_olfactory_epithelium0.98062736
72MP0002752_abnormal_somatic_nervous0.96546432
73MP0008775_abnormal_heart_ventricle0.96446458
74MP0005386_behavior/neurological_phenoty0.96407463
75MP0004924_abnormal_behavior0.96407463
76MP0002063_abnormal_learning/memory/cond0.93283961
77MP0000647_abnormal_sebaceous_gland0.92335757
78MP0003121_genomic_imprinting0.91715984
79MP0003635_abnormal_synaptic_transmissio0.90957031
80MP0001502_abnormal_circadian_rhythm0.90941922
81MP0002184_abnormal_innervation0.90627605
82MP0003137_abnormal_impulse_conducting0.89285665
83MP0008058_abnormal_DNA_repair0.88366245
84MP0004215_abnormal_myocardial_fiber0.88105942
85MP0001919_abnormal_reproductive_system0.87823742
86MP0001293_anophthalmia0.85277724
87MP0003718_maternal_effect0.84572341
88MP0002282_abnormal_trachea_morphology0.84128106
89MP0003698_abnormal_male_reproductive0.83195708
90MP0002229_neurodegeneration0.83135768
91MP0004145_abnormal_muscle_electrophysio0.82575700
92MP0002734_abnormal_mechanical_nocicepti0.82240710
93MP0001324_abnormal_eye_pigmentation0.81731389
94MP0001764_abnormal_homeostasis0.81319409
95MP0010678_abnormal_skin_adnexa0.80538436
96MP0000230_abnormal_systemic_arterial0.80222053
97MP0010386_abnormal_urinary_bladder0.79931363
98MP0005085_abnormal_gallbladder_physiolo0.78969984
99MP0003890_abnormal_embryonic-extraembry0.78264059
100MP0005083_abnormal_biliary_tract0.77445533

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.44000138
2Molar tooth sign on MRI (HP:0002419)4.22939128
3Abnormality of midbrain morphology (HP:0002418)4.22939128
4Pancreatic fibrosis (HP:0100732)4.17693265
5True hermaphroditism (HP:0010459)3.99129042
6Congenital stationary night blindness (HP:0007642)3.93735120
7Nephronophthisis (HP:0000090)3.90569790
8Type II lissencephaly (HP:0007260)3.48103006
9Abnormality of the renal cortex (HP:0011035)3.36835705
10Abnormality of the renal medulla (HP:0100957)3.34926488
11Medial flaring of the eyebrow (HP:0010747)3.31292876
12Chronic hepatic failure (HP:0100626)2.91242140
13Renal cortical cysts (HP:0000803)2.84856979
14Gait imbalance (HP:0002141)2.79877495
15Tubular atrophy (HP:0000092)2.78014077
16Hyperventilation (HP:0002883)2.73704431
17Attenuation of retinal blood vessels (HP:0007843)2.67721916
18Cystic liver disease (HP:0006706)2.66320099
19Abolished electroretinogram (ERG) (HP:0000550)2.64387724
20Congenital primary aphakia (HP:0007707)2.62732806
21Polydipsia (HP:0001959)2.59290948
22Abnormal drinking behavior (HP:0030082)2.59290948
23Sclerocornea (HP:0000647)2.56394746
24Hepatocellular necrosis (HP:0001404)2.56070508
25Methylmalonic acidemia (HP:0002912)2.55445530
26Abnormal rod and cone electroretinograms (HP:0008323)2.51681000
27Mitochondrial inheritance (HP:0001427)2.46621239
28Acute necrotizing encephalopathy (HP:0006965)2.43572942
29Nephrogenic diabetes insipidus (HP:0009806)2.43206084
30Bile duct proliferation (HP:0001408)2.40485218
31Abnormal biliary tract physiology (HP:0012439)2.40485218
32Lissencephaly (HP:0001339)2.39353454
33Pendular nystagmus (HP:0012043)2.38486168
34Hepatic necrosis (HP:0002605)2.37625443
35Increased CSF lactate (HP:0002490)2.37206546
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33326751
37Inability to walk (HP:0002540)2.29141658
383-Methylglutaconic aciduria (HP:0003535)2.26689478
39Genital tract atresia (HP:0001827)2.23855104
40Hypothermia (HP:0002045)2.22736833
41Large for gestational age (HP:0001520)2.22576442
42Aplasia/hypoplasia of the uterus (HP:0008684)2.22357113
43Methylmalonic aciduria (HP:0012120)2.21482230
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.20885027
45Progressive macrocephaly (HP:0004481)2.20628670
46Increased corneal curvature (HP:0100692)2.20444508
47Keratoconus (HP:0000563)2.20444508
48Progressive cerebellar ataxia (HP:0002073)2.20116463
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19953890
50Optic nerve hypoplasia (HP:0000609)2.19221331
51Cerebellar dysplasia (HP:0007033)2.19200223
52Acute encephalopathy (HP:0006846)2.18072602
53Anencephaly (HP:0002323)2.17976543
54Hyperglycinemia (HP:0002154)2.16975694
55Congenital hepatic fibrosis (HP:0002612)2.15335846
56Congenital, generalized hypertrichosis (HP:0004540)2.14055390
57Oligodactyly (hands) (HP:0001180)2.13942177
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.13753427
59Absent/shortened dynein arms (HP:0200106)2.13753427
60Pachygyria (HP:0001302)2.13524549
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12826531
62Furrowed tongue (HP:0000221)2.11878928
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.10840325
64Abnormal mitochondria in muscle tissue (HP:0008316)2.10653265
65Vaginal atresia (HP:0000148)2.10296808
66Decreased central vision (HP:0007663)2.09618980
67Abnormality of alanine metabolism (HP:0010916)2.03450489
68Hyperalaninemia (HP:0003348)2.03450489
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03450489
70Abnormal respiratory motile cilium morphology (HP:0005938)2.02729711
71Abnormal respiratory epithelium morphology (HP:0012253)2.02729711
72Gaze-evoked nystagmus (HP:0000640)1.99522280
73Polyuria (HP:0000103)1.97341939
74Male pseudohermaphroditism (HP:0000037)1.96188610
75Optic disc pallor (HP:0000543)1.95778686
76Severe muscular hypotonia (HP:0006829)1.95571959
77Progressive inability to walk (HP:0002505)1.95551591
78Anophthalmia (HP:0000528)1.95110177
79Retinal dysplasia (HP:0007973)1.94873851
80Postaxial foot polydactyly (HP:0001830)1.94775692
81Abnormality of the pons (HP:0007361)1.94726646
82Bilateral microphthalmos (HP:0007633)1.93022926
83Constricted visual fields (HP:0001133)1.91506914
84Decreased circulating renin level (HP:0003351)1.90521939
85Hypoplasia of the pons (HP:0012110)1.88748160
86Lipid accumulation in hepatocytes (HP:0006561)1.87573708
87Patellar aplasia (HP:0006443)1.84227398
88Congenital sensorineural hearing impairment (HP:0008527)1.83599996
89Intestinal atresia (HP:0011100)1.83584365
90Concave nail (HP:0001598)1.81981731
91Postaxial hand polydactyly (HP:0001162)1.81254446
92Disproportionate short-trunk short stature (HP:0003521)1.81218899
93Aplasia/Hypoplasia of the patella (HP:0006498)1.78561292
94Short tibia (HP:0005736)1.77193902
95Hyperglycinuria (HP:0003108)1.76740541
96Occipital encephalocele (HP:0002085)1.75210472
97Abnormality of glycine metabolism (HP:0010895)1.75136028
98Abnormality of serine family amino acid metabolism (HP:0010894)1.75136028
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.74034318
100Hypoplasia of the uterus (HP:0000013)1.73509549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.83163110
2MAP4K23.63488702
3BMPR1B3.32270410
4WNK33.09557263
5ADRBK23.06030918
6ZAK2.74370805
7PINK12.67365926
8NUAK12.27582462
9WNK42.23498161
10GRK12.20762536
11TAOK32.12447708
12MAPK132.11187995
13CASK2.01145900
14MAP3K41.93968635
15TLK11.91526837
16INSRR1.83698000
17ACVR1B1.71265858
18BCKDK1.59895199
19TNIK1.42509122
20STK391.40481643
21OXSR11.39523259
22TXK1.38370898
23MAP2K71.32667735
24DYRK21.31904914
25PHKG11.25069158
26PHKG21.25069158
27TGFBR11.21777140
28DAPK21.20188803
29MKNK21.18429682
30MARK11.14769512
31CAMKK21.08511823
32VRK11.06330361
33NME11.06242008
34ADRBK11.06184860
35CSNK1G31.04677972
36TRIM281.03951332
37CSNK1G21.02643681
38PAK31.02471519
39ERBB31.02273021
40CSNK1G10.97782036
41PRKCE0.96681674
42PIK3CA0.94657569
43NTRK30.93707764
44PLK20.93694171
45NTRK20.92051045
46PRKCG0.88790591
47CSNK1A1L0.88339548
48EPHA30.86586778
49MAPK150.84187242
50MAPKAPK30.83818844
51VRK20.83061836
52STK160.82248426
53PNCK0.79668775
54BCR0.74794258
55PKN10.72137085
56STK38L0.70040724
57MST40.67633033
58PLK30.65305952
59PRKCI0.63961976
60PRKCQ0.63207821
61TEC0.62451103
62EIF2AK30.61917144
63FGFR20.60186028
64RPS6KA50.59700080
65PLK40.58741168
66MUSK0.58643877
67CAMK2A0.56132082
68MAP2K60.56019917
69PRKD30.55235906
70IKBKB0.55233342
71PTK2B0.54957564
72BRSK20.54819221
73MKNK10.54528829
74CSNK1A10.53552657
75IRAK10.52096148
76TAF10.49463260
77MAPKAPK50.48595817
78CHUK0.48244441
79TIE10.46485633
80LIMK10.45476588
81PRKCZ0.45257605
82CAMK10.43877041
83FER0.43225835
84PRKACA0.42558323
85SIK20.41881264
86STK110.41466971
87KIT0.41366433
88FLT30.37631911
89STK30.36509618
90EIF2AK20.33477006
91CSNK1D0.33047441
92EPHA40.32053275
93MINK10.31940443
94MAP2K40.29934639
95PAK60.29632628
96ITK0.29166912
97CHEK20.27939859
98PRKCA0.27410082
99PLK10.27255824
100CDK80.26669063

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.72670977
2Phototransduction_Homo sapiens_hsa047442.71801339
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67998389
4Linoleic acid metabolism_Homo sapiens_hsa005912.67143597
5Oxidative phosphorylation_Homo sapiens_hsa001902.59911504
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51744405
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32777693
8Selenocompound metabolism_Homo sapiens_hsa004502.27871071
9Protein export_Homo sapiens_hsa030602.24728264
10Butanoate metabolism_Homo sapiens_hsa006502.18865722
11Nitrogen metabolism_Homo sapiens_hsa009102.16697650
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12157163
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11280137
14Parkinsons disease_Homo sapiens_hsa050122.00834972
15Nicotine addiction_Homo sapiens_hsa050332.00028921
16Caffeine metabolism_Homo sapiens_hsa002321.95719404
17Ether lipid metabolism_Homo sapiens_hsa005651.93933709
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89943509
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.83290357
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81663321
21RNA polymerase_Homo sapiens_hsa030201.68259467
22Propanoate metabolism_Homo sapiens_hsa006401.64545472
23Tryptophan metabolism_Homo sapiens_hsa003801.62783147
24Basal transcription factors_Homo sapiens_hsa030221.56399808
25Homologous recombination_Homo sapiens_hsa034401.53098403
26Fanconi anemia pathway_Homo sapiens_hsa034601.52101305
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43700181
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32996931
29Huntingtons disease_Homo sapiens_hsa050161.31867204
30Peroxisome_Homo sapiens_hsa041461.24096658
31Arachidonic acid metabolism_Homo sapiens_hsa005901.21347139
32RNA degradation_Homo sapiens_hsa030181.21338031
33Alzheimers disease_Homo sapiens_hsa050101.19550537
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16050474
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15513304
36Taste transduction_Homo sapiens_hsa047421.08956290
37Morphine addiction_Homo sapiens_hsa050321.08035686
38Collecting duct acid secretion_Homo sapiens_hsa049661.07724076
39Regulation of autophagy_Homo sapiens_hsa041401.06237614
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05318925
41Proteasome_Homo sapiens_hsa030501.04550481
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.03834560
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.03678065
44Chemical carcinogenesis_Homo sapiens_hsa052041.03463921
45Cardiac muscle contraction_Homo sapiens_hsa042601.03440113
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.02228651
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01730754
48Olfactory transduction_Homo sapiens_hsa047400.96588779
49ABC transporters_Homo sapiens_hsa020100.95877355
50One carbon pool by folate_Homo sapiens_hsa006700.94628065
51GABAergic synapse_Homo sapiens_hsa047270.86991953
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83796654
53Serotonergic synapse_Homo sapiens_hsa047260.83118352
54Steroid biosynthesis_Homo sapiens_hsa001000.78410967
55Non-homologous end-joining_Homo sapiens_hsa034500.78349049
56Insulin secretion_Homo sapiens_hsa049110.77580268
57Fat digestion and absorption_Homo sapiens_hsa049750.77128157
58Retinol metabolism_Homo sapiens_hsa008300.76184637
59Sulfur metabolism_Homo sapiens_hsa009200.76169691
60Sulfur relay system_Homo sapiens_hsa041220.75371261
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73677358
62Ovarian steroidogenesis_Homo sapiens_hsa049130.72253159
63Metabolic pathways_Homo sapiens_hsa011000.71644591
64Purine metabolism_Homo sapiens_hsa002300.71297269
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69929969
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68909061
67beta-Alanine metabolism_Homo sapiens_hsa004100.68530130
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68416232
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67599383
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66983128
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65909617
72Circadian entrainment_Homo sapiens_hsa047130.65886736
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65527672
74Glycerolipid metabolism_Homo sapiens_hsa005610.64502346
75Glutamatergic synapse_Homo sapiens_hsa047240.62919012
76Histidine metabolism_Homo sapiens_hsa003400.62233808
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59898813
78Vitamin digestion and absorption_Homo sapiens_hsa049770.58474136
79Mineral absorption_Homo sapiens_hsa049780.57884779
80Salivary secretion_Homo sapiens_hsa049700.55415334
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.54437080
82Calcium signaling pathway_Homo sapiens_hsa040200.54295682
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53665870
84Asthma_Homo sapiens_hsa053100.52421097
85Pyrimidine metabolism_Homo sapiens_hsa002400.49768193
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48332497
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.48247451
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47415662
89Fatty acid elongation_Homo sapiens_hsa000620.46962273
90Type I diabetes mellitus_Homo sapiens_hsa049400.46626767
91Dopaminergic synapse_Homo sapiens_hsa047280.45604694
92Circadian rhythm_Homo sapiens_hsa047100.44974353
93Cocaine addiction_Homo sapiens_hsa050300.44157481
94Ribosome_Homo sapiens_hsa030100.42203971
95Fatty acid degradation_Homo sapiens_hsa000710.41931621
96Hedgehog signaling pathway_Homo sapiens_hsa043400.38671769
97Primary immunodeficiency_Homo sapiens_hsa053400.36761877
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.35162227
99Fatty acid metabolism_Homo sapiens_hsa012120.33134610
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32257799

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