ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	5.94582698
2	sequestering of actin monomers (GO:0042989)	4.79764832
3	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.52316213
4	platelet dense granule organization (GO:0060155)	4.36862687
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.29061626
6	epithelial cilium movement (GO:0003351)	4.21191303
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.98324195
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.81434835
9	ATP synthesis coupled proton transport (GO:0015986)	3.81434835
10	respiratory electron transport chain (GO:0022904)	3.61054751
11	cilium movement (GO:0003341)	3.58110157
12	electron transport chain (GO:0022900)	3.56287418
13	positive regulation of mitochondrial fission (GO:0090141)	3.27995369
14	aldehyde catabolic process (GO:0046185)	3.23071084
15	axoneme assembly (GO:0035082)	3.07650594
16	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.03172980
17	axonemal dynein complex assembly (GO:0070286)	3.02971256
18	negative regulation of heart rate (GO:0010459)	2.98177467
19	protein complex biogenesis (GO:0070271)	2.97703991
20	intraciliary transport (GO:0042073)	2.90728359
21	regulation of cilium movement (GO:0003352)	2.84861341
22	negative regulation of appetite (GO:0032099)	2.80918116
23	negative regulation of response to food (GO:0032096)	2.80918116
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.70662125
25	NADH dehydrogenase complex assembly (GO:0010257)	2.70662125
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.70662125
27	low-density lipoprotein particle remodeling (GO:0034374)	2.65450640
28	nonmotile primary cilium assembly (GO:0035058)	2.63912152
29	proton transport (GO:0015992)	2.60251339
30	protein localization to cilium (GO:0061512)	2.59800362
31	hydrogen transport (GO:0006818)	2.59598369
32	pyrimidine nucleobase catabolic process (GO:0006208)	2.59319734
33	cilium morphogenesis (GO:0060271)	2.58619800
34	hydrogen ion transmembrane transport (GO:1902600)	2.56910352
35	GPI anchor metabolic process (GO:0006505)	2.56122269
36	GPI anchor biosynthetic process (GO:0006506)	2.53724305
37	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53200205
38	cilium or flagellum-dependent cell motility (GO:0001539)	2.50409204
39	peroxisome fission (GO:0016559)	2.50068304
40	chaperone-mediated protein transport (GO:0072321)	2.47910478
41	ATP biosynthetic process (GO:0006754)	2.46461124
42	cilium organization (GO:0044782)	2.44519706
43	mannosylation (GO:0097502)	2.43790636
44	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.41005683
45	cilium assembly (GO:0042384)	2.40978982
46	water-soluble vitamin biosynthetic process (GO:0042364)	2.40200447
47	L-ascorbic acid metabolic process (GO:0019852)	2.39499489
48	organelle disassembly (GO:1903008)	2.36071748
49	negative regulation of cation channel activity (GO:2001258)	2.29397347
50	negative regulation of membrane potential (GO:0045837)	2.28913896
51	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.28208044
52	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.26653115
53	glutathione derivative biosynthetic process (GO:1901687)	2.26414828
54	glutathione derivative metabolic process (GO:1901685)	2.26414828
55	cotranslational protein targeting to membrane (GO:0006613)	2.26008069
56	heart process (GO:0003015)	2.25529583
57	heart contraction (GO:0060047)	2.25529583
58	protein localization to endoplasmic reticulum (GO:0070972)	2.25260972
59	retinal ganglion cell axon guidance (GO:0031290)	2.24654342
60	xenobiotic catabolic process (GO:0042178)	2.24216391
61	protein targeting to ER (GO:0045047)	2.24138498
62	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.23689595
63	reverse cholesterol transport (GO:0043691)	2.23322842
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.22910213
65	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.21883034
66	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.21883034
67	cellular response to zinc ion (GO:0071294)	2.21265800
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.20694842
69	adenosine metabolic process (GO:0046085)	2.20123140
70	dopamine transport (GO:0015872)	2.19440098
71	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.18866335
72	nucleobase catabolic process (GO:0046113)	2.18320094
73	vascular smooth muscle contraction (GO:0014829)	2.17738988
74	positive regulation of TOR signaling (GO:0032008)	2.15592504
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.15501498
76	membrane budding (GO:0006900)	2.15442952
77	cellular response to leptin stimulus (GO:0044320)	2.14335932
78	presynaptic membrane assembly (GO:0097105)	2.13101661
79	blood coagulation, intrinsic pathway (GO:0007597)	2.12586093
80	behavioral response to nicotine (GO:0035095)	2.12518212
81	ADP metabolic process (GO:0046031)	2.11393147
82	regulation of lipoprotein metabolic process (GO:0050746)	2.10253579
83	artery smooth muscle contraction (GO:0014824)	2.10153466
84	neuronal action potential propagation (GO:0019227)	2.09553404
85	cullin deneddylation (GO:0010388)	2.09187427
86	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.08870927
87	L-phenylalanine catabolic process (GO:0006559)	2.08870927
88	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.08868183
89	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.08868183
90	regulation of mitochondrial fission (GO:0090140)	2.08091274
91	respiratory chain complex IV assembly (GO:0008535)	2.07952404
92	left/right pattern formation (GO:0060972)	2.07700835
93	anterograde synaptic vesicle transport (GO:0048490)	2.07126626
94	regulation of appetite (GO:0032098)	2.06759849
95	nucleoside diphosphate phosphorylation (GO:0006165)	2.06537843
96	glycolipid biosynthetic process (GO:0009247)	2.06302007
97	high-density lipoprotein particle remodeling (GO:0034375)	2.05502141
98	left/right axis specification (GO:0070986)	2.05284304
99	melanosome transport (GO:0032402)	2.04913829
100	neuron fate determination (GO:0048664)	2.04567198

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.63795500
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57391359
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46440587
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33537456
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27239433
6	VDR_22108803_ChIP-Seq_LS180_Human	2.26931650
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.25981300
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.24849102
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22575523
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20137626
11	P300_19829295_ChIP-Seq_ESCs_Human	2.00824210
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88703737
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.86951674
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.84525790
15	EWS_26573619_Chip-Seq_HEK293_Human	1.84153370
16	EZH2_22144423_ChIP-Seq_EOC_Human	1.78941180
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75205170
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73192030
19	FUS_26573619_Chip-Seq_HEK293_Human	1.72682728
20	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.71067038
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.68444678
22	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67727559
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64494363
24	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47103843
25	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.42218304
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41035900
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40711090
28	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39411127
29	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39411127
30	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.38319713
31	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.38319713
32	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38024171
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37766057
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37340650
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.36085248
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35523475
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.35502047
38	AR_25329375_ChIP-Seq_VCAP_Human	1.35475038
39	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.35022051
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34968131
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34949213
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33593249
43	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.30856810
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30284654
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30208526
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29829794
47	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29406947
48	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.27166525
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26811209
50	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25270652
51	P53_22387025_ChIP-Seq_ESCs_Mouse	1.25252276
52	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.24090183
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23309551
54	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23279962
55	* AR_20517297_ChIP-Seq_VCAP_Human	1.22813227
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21516135
57	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20992022
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.19402222
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18695117
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.17282855
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16438755
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16438755
63	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15269378
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14067417
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13128111
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.12167308
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11200828
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11078965
69	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.10796595
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10470584
71	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10365366
72	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08578851
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08000930
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.07722834
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07722834
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06426838
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05895692
78	TP53_22573176_ChIP-Seq_HFKS_Human	1.05491811
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04759711
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02854537
81	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.02550449
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01940501
83	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01475361
84	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.00354957
85	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99493034
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98433361
87	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98005041
88	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97881065
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97802885
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96853593
91	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96775552
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.95385341
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.93841720
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.93773172
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.93101862
96	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.92740448
97	NCOR_22424771_ChIP-Seq_293T_Human	0.92508272
98	* CDX2_22108803_ChIP-Seq_LS180_Human	0.91038362
99	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.91026255
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90165551

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	3.18487444
2	MP0003011_delayed_dark_adaptation	2.88524690
3	MP0006054_spinal_hemorrhage	2.79607076
4	MP0003880_abnormal_central_pattern	2.75164122
5	MP0003724_increased_susceptibility_to	2.55437985
6	MP0003195_calcinosis	2.50820219
7	MP0002653_abnormal_ependyma_morphology	2.43768166
8	MP0006072_abnormal_retinal_apoptosis	2.26103855
9	MP0001984_abnormal_olfaction	2.26101255
10	MP0001529_abnormal_vocalization	2.01088479
11	MP0002638_abnormal_pupillary_reflex	1.97689380
12	MP0003787_abnormal_imprinting	1.79814374
13	MP0010386_abnormal_urinary_bladder	1.77973387
14	MP0009379_abnormal_foot_pigmentation	1.77899809
15	MP0002102_abnormal_ear_morphology	1.64707543
16	MP0005253_abnormal_eye_physiology	1.64178894
17	MP0005085_abnormal_gallbladder_physiolo	1.63597498
18	MP0005551_abnormal_eye_electrophysiolog	1.63118597
19	MP0005084_abnormal_gallbladder_morpholo	1.60854656
20	MP0005365_abnormal_bile_salt	1.59013427
21	MP0002736_abnormal_nociception_after	1.57600167
22	MP0004885_abnormal_endolymph	1.57567713
23	MP0010329_abnormal_lipoprotein_level	1.56877862
24	MP0003136_yellow_coat_color	1.55714769
25	MP0006276_abnormal_autonomic_nervous	1.53276929
26	MP0005167_abnormal_blood-brain_barrier	1.52999405
27	MP0004142_abnormal_muscle_tone	1.52933016
28	MP0003121_genomic_imprinting	1.51380871
29	MP0009780_abnormal_chondrocyte_physiolo	1.48246658
30	MP0003878_abnormal_ear_physiology	1.46236150
31	MP0005377_hearing/vestibular/ear_phenot	1.46236150
32	MP0008875_abnormal_xenobiotic_pharmacok	1.41538979
33	MP0002909_abnormal_adrenal_gland	1.40872125
34	MP0003186_abnormal_redox_activity	1.40498169
35	MP0001968_abnormal_touch/_nociception	1.36309484
36	MP0005360_urolithiasis	1.30215688
37	MP0002822_catalepsy	1.29793462
38	MP0005464_abnormal_platelet_physiology	1.27489037
39	MP0004215_abnormal_myocardial_fiber	1.27278211
40	MP0002876_abnormal_thyroid_physiology	1.26283285
41	MP0002837_dystrophic_cardiac_calcinosis	1.25908150
42	MP0008789_abnormal_olfactory_epithelium	1.24544447
43	MP0004133_heterotaxia	1.22908747
44	MP0001905_abnormal_dopamine_level	1.22372728
45	MP0001486_abnormal_startle_reflex	1.17386006
46	MP0002282_abnormal_trachea_morphology	1.16804244
47	MP0009745_abnormal_behavioral_response	1.11439982
48	MP0008004_abnormal_stomach_pH	1.10983046
49	MP0002938_white_spotting	1.09334823
50	MP0002272_abnormal_nervous_system	1.09239947
51	MP0002132_abnormal_respiratory_system	1.06460791
52	MP0005275_abnormal_skin_tensile	1.06255167
53	MP0001970_abnormal_pain_threshold	1.05442886
54	MP0000343_altered_response_to	1.03739380
55	MP0001485_abnormal_pinna_reflex	1.03686714
56	MP0008872_abnormal_physiological_respon	1.01932925
57	MP0004270_analgesia	0.99811711
58	MP0004043_abnormal_pH_regulation	0.98732140
59	MP0005646_abnormal_pituitary_gland	0.98182955
60	MP0000230_abnormal_systemic_arterial	0.97656148
61	MP0000639_abnormal_adrenal_gland	0.97086054
62	MP0010368_abnormal_lymphatic_system	0.95218549
63	MP0002735_abnormal_chemical_nociception	0.94524757
64	MP0009785_altered_susceptibility_to	0.94105697
65	MP0001756_abnormal_urination	0.93118126
66	MP0002734_abnormal_mechanical_nocicepti	0.93008080
67	MP0005671_abnormal_response_to	0.92295830
68	MP0002572_abnormal_emotion/affect_behav	0.91535014
69	MP0002277_abnormal_respiratory_mucosa	0.91070137
70	MP0004147_increased_porphyrin_level	0.90977147
71	MP0002067_abnormal_sensory_capabilities	0.90583843
72	MP0001879_abnormal_lymphatic_vessel	0.89930418
73	MP0002557_abnormal_social/conspecific_i	0.89304240
74	MP0002090_abnormal_vision	0.89140468
75	MP0005499_abnormal_olfactory_system	0.87508973
76	MP0005394_taste/olfaction_phenotype	0.87508973
77	MP0001986_abnormal_taste_sensitivity	0.87198980
78	MP0001501_abnormal_sleep_pattern	0.84630491
79	MP0002295_abnormal_pulmonary_circulatio	0.84307545
80	MP0006036_abnormal_mitochondrial_physio	0.83909161
81	MP0001542_abnormal_bone_strength	0.83864679
82	MP0009046_muscle_twitch	0.83217848
83	MP0005503_abnormal_tendon_morphology	0.81825085
84	MP0005195_abnormal_posterior_eye	0.78173734
85	MP0004484_altered_response_of	0.78161879
86	MP0004084_abnormal_cardiac_muscle	0.76838850
87	MP0000778_abnormal_nervous_system	0.76382474
88	MP0001764_abnormal_homeostasis	0.76359484
89	MP0000372_irregular_coat_pigmentation	0.75331716
90	MP0000026_abnormal_inner_ear	0.74808172
91	MP0004019_abnormal_vitamin_homeostasis	0.74603528
92	MP0006082_CNS_inflammation	0.74164704
93	MP0005248_abnormal_Harderian_gland	0.73582648
94	MP0003567_abnormal_fetal_cardiomyocyte	0.72227394
95	MP0005332_abnormal_amino_acid	0.72181286
96	MP0003252_abnormal_bile_duct	0.72022085
97	MP0009764_decreased_sensitivity_to	0.71670745
98	MP0004145_abnormal_muscle_electrophysio	0.71628937
99	MP0003638_abnormal_response/metabolism_	0.71537843
100	MP0002733_abnormal_thermal_nociception	0.71067199

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.08557249
2	True hermaphroditism (HP:0010459)	3.84849042
3	Progressive macrocephaly (HP:0004481)	3.71692940
4	Medial flaring of the eyebrow (HP:0010747)	3.70804877
5	3-Methylglutaconic aciduria (HP:0003535)	3.66981921
6	Mitochondrial inheritance (HP:0001427)	3.61973760
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.59229004
8	Acute encephalopathy (HP:0006846)	3.58608572
9	Abnormal respiratory epithelium morphology (HP:0012253)	3.57457575
10	Abnormal respiratory motile cilium morphology (HP:0005938)	3.57457575
11	Pancreatic fibrosis (HP:0100732)	3.51955370
12	Abnormal ciliary motility (HP:0012262)	3.49940936
13	Congenital, generalized hypertrichosis (HP:0004540)	3.46887515
14	Pancreatic cysts (HP:0001737)	3.35174073
15	Abnormal respiratory motile cilium physiology (HP:0012261)	3.24057453
16	Gait imbalance (HP:0002141)	3.14062999
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.10943233
18	Absent/shortened dynein arms (HP:0200106)	3.10943233
19	Congenital primary aphakia (HP:0007707)	3.08228750
20	Abnormality of midbrain morphology (HP:0002418)	2.97597344
21	Molar tooth sign on MRI (HP:0002419)	2.97597344
22	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.96070079
23	Hepatic necrosis (HP:0002605)	2.94913921
24	Increased CSF lactate (HP:0002490)	2.88904396
25	Renal Fanconi syndrome (HP:0001994)	2.86574912
26	Hepatocellular necrosis (HP:0001404)	2.79302698
27	Nephrogenic diabetes insipidus (HP:0009806)	2.76970357
28	Nephronophthisis (HP:0000090)	2.76822645
29	Increased hepatocellular lipid droplets (HP:0006565)	2.74612354
30	Rhinitis (HP:0012384)	2.58918094
31	Type 2 muscle fiber atrophy (HP:0003554)	2.57965300
32	Hyperglycinemia (HP:0002154)	2.55683301
33	Polyphagia (HP:0002591)	2.50475766
34	Hypothermia (HP:0002045)	2.49476330
35	Genital tract atresia (HP:0001827)	2.48031533
36	Vaginal atresia (HP:0000148)	2.47175189
37	Chronic sinusitis (HP:0011109)	2.45302698
38	Methylmalonic acidemia (HP:0002912)	2.43037981
39	Exertional dyspnea (HP:0002875)	2.38341540
40	Lipid accumulation in hepatocytes (HP:0006561)	2.37242508
41	Abnormality of the renal medulla (HP:0100957)	2.35399660
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.33283026
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.33283026
44	Cerebral edema (HP:0002181)	2.29121578
45	Renal cortical cysts (HP:0000803)	2.26879178
46	Optic disc pallor (HP:0000543)	2.26452127
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22605410
48	Abnormality of secondary sexual hair (HP:0009888)	2.20479606
49	Abnormality of the axillary hair (HP:0100134)	2.20479606
50	Supernumerary spleens (HP:0009799)	2.20275323
51	Delayed CNS myelination (HP:0002188)	2.19606398
52	Glycosuria (HP:0003076)	2.16972751
53	Abnormality of urine glucose concentration (HP:0011016)	2.16972751
54	Cystic liver disease (HP:0006706)	2.16084373
55	Generalized aminoaciduria (HP:0002909)	2.13069906
56	Increased intramyocellular lipid droplets (HP:0012240)	2.11416033
57	Abnormality of the renal cortex (HP:0011035)	2.08378017
58	Hypoglycemic coma (HP:0001325)	2.04267192
59	Occipital encephalocele (HP:0002085)	2.03752916
60	Congenital hepatic fibrosis (HP:0002612)	2.02798278
61	Purpura (HP:0000979)	1.99144122
62	Decreased central vision (HP:0007663)	1.98928180
63	Respiratory failure (HP:0002878)	1.98261318
64	Muscle fiber atrophy (HP:0100295)	1.98023974
65	Male pseudohermaphroditism (HP:0000037)	1.97231019
66	Methylmalonic aciduria (HP:0012120)	1.95847461
67	Postaxial hand polydactyly (HP:0001162)	1.95760423
68	Furrowed tongue (HP:0000221)	1.93862616
69	Abolished electroretinogram (ERG) (HP:0000550)	1.87977676
70	Abnormality of renal resorption (HP:0011038)	1.87967989
71	Postaxial foot polydactyly (HP:0001830)	1.87113043
72	Lethargy (HP:0001254)	1.86631713
73	Metaphyseal dysplasia (HP:0100255)	1.86541023
74	Focal motor seizures (HP:0011153)	1.85420450
75	Exercise intolerance (HP:0003546)	1.83271056
76	Hyperphosphaturia (HP:0003109)	1.80359176
77	Abnormal drinking behavior (HP:0030082)	1.76735600
78	Polydipsia (HP:0001959)	1.76735600
79	Lactic acidosis (HP:0003128)	1.76504236
80	Sclerocornea (HP:0000647)	1.76182284
81	Broad foot (HP:0001769)	1.75294200
82	Abnormality of serine family amino acid metabolism (HP:0010894)	1.73051903
83	Abnormality of glycine metabolism (HP:0010895)	1.73051903
84	Neuroendocrine neoplasm (HP:0100634)	1.72611510
85	Hyperglycinuria (HP:0003108)	1.72249942
86	Congenital stationary night blindness (HP:0007642)	1.66988769
87	Thyroid-stimulating hormone excess (HP:0002925)	1.66498917
88	Exercise-induced muscle cramps (HP:0003710)	1.66341967
89	Increased muscle lipid content (HP:0009058)	1.65382585
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.64806261
91	Decreased muscle mass (HP:0003199)	1.63608259
92	Left ventricular hypertrophy (HP:0001712)	1.63608035
93	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.62908463
94	Febrile seizures (HP:0002373)	1.62779510
95	Aplasia/Hypoplasia of the lens (HP:0008063)	1.62612672
96	Delayed gross motor development (HP:0002194)	1.62301537
97	Anencephaly (HP:0002323)	1.61299796
98	Hyperinsulinemic hypoglycemia (HP:0000825)	1.61226146
99	Leukodystrophy (HP:0002415)	1.61079881
100	Menorrhagia (HP:0000132)	1.60560558

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.00510349
2	BCR	2.84334504
3	BMPR1B	2.72883254
4	STK16	2.32507527
5	BCKDK	2.13286187
6	WNK3	2.05805655
7	TRIM28	1.94403386
8	TNIK	1.91453192
9	ERBB3	1.78395793
10	TXK	1.76811370
11	PLK2	1.75003460
12	MAPK13	1.73065102
13	LIMK1	1.72932317
14	ADRBK2	1.65682024
15	GRK1	1.64423249
16	MYLK	1.64349249
17	MAP3K12	1.62423656
18	FRK	1.51418505
19	PINK1	1.50493137
20	MST4	1.48269510
21	FLT3	1.47135025
22	CSNK1G2	1.43134142
23	EPHA4	1.39978384
24	CAMKK2	1.39454666
25	EPHA3	1.28905265
26	MARK1	1.25419830
27	ACVR1B	1.21751303
28	DYRK2	1.20525262
29	MAPKAPK3	1.17501156
30	MAP3K4	1.17462152
31	MAPK15	1.17309693
32	CASK	1.16306147
33	TAOK3	1.15891550
34	DYRK3	1.15235646
35	INSRR	1.13595200
36	CSNK1G3	1.13575298
37	TESK1	1.11343200
38	TIE1	1.10814217
39	EPHB2	1.09076500
40	NUAK1	1.05511056
41	MAP2K7	1.02788344
42	KIT	1.01244145
43	CDK19	1.00637677
44	PAK3	0.99336730
45	GRK7	0.98844007
46	TGFBR1	0.94964010
47	NTRK2	0.93054314
48	WNK4	0.90503144
49	MINK1	0.89783595
50	GRK5	0.89557618
51	ADRBK1	0.88242675
52	PRKCE	0.85935809
53	CSNK1G1	0.85141111
54	MUSK	0.83396563
55	CSNK1A1L	0.82991911
56	VRK1	0.82123274
57	VRK2	0.81291548
58	RPS6KA4	0.79377542
59	FER	0.75939188
60	DYRK1B	0.73302950
61	PRKCG	0.69888491
62	TLK1	0.68505413
63	PIK3CA	0.68470611
64	CAMK2A	0.64692055
65	OXSR1	0.64445017
66	PASK	0.64064983
67	ZAK	0.60925148
68	PTK2B	0.60576072
69	TEC	0.60271439
70	PIK3CG	0.60181952
71	STK24	0.58573571
72	BMPR2	0.57747529
73	CDK8	0.57293123
74	LYN	0.56583304
75	STK39	0.55709252
76	CSF1R	0.55188340
77	PRKG1	0.55078228
78	SYK	0.54959198
79	PHKG1	0.54329574
80	PHKG2	0.54329574
81	TESK2	0.53959231
82	FES	0.53443748
83	SIK3	0.53427449
84	OBSCN	0.53372639
85	PRKACA	0.52021954
86	PKN1	0.51936063
87	MOS	0.49905859
88	ARAF	0.49792414
89	CAMKK1	0.49704896
90	KDR	0.47632731
91	MATK	0.46475085
92	DAPK2	0.46252635
93	TGFBR2	0.46005147
94	IGF1R	0.45952492
95	ILK	0.45904335
96	FGFR1	0.45895645
97	DDR2	0.45804685
98	UHMK1	0.45770844
99	ITK	0.42762145
100	ERBB2	0.41494178

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.05768315
2	Protein export_Homo sapiens_hsa03060	3.79995277
3	Parkinsons disease_Homo sapiens_hsa05012	3.30678080
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.49196145
5	Alzheimers disease_Homo sapiens_hsa05010	2.19111317
6	Huntingtons disease_Homo sapiens_hsa05016	2.04243574
7	Ribosome_Homo sapiens_hsa03010	2.01717880
8	Fatty acid elongation_Homo sapiens_hsa00062	1.92287038
9	Propanoate metabolism_Homo sapiens_hsa00640	1.90308603
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85508231
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77076195
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75624615
13	Asthma_Homo sapiens_hsa05310	1.73545864
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.66529624
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.64113976
16	Peroxisome_Homo sapiens_hsa04146	1.61783001
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.59555634
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56879423
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.55469554
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.51754431
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.49994512
22	Butanoate metabolism_Homo sapiens_hsa00650	1.47300752
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39028218
24	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.37270221
25	Phototransduction_Homo sapiens_hsa04744	1.36642299
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.36146136
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34992646
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.30578852
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30536249
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.30193908
31	Proteasome_Homo sapiens_hsa03050	1.23552348
32	Allograft rejection_Homo sapiens_hsa05330	1.23528857
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.21155422
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.19558519
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.19391994
36	Fatty acid degradation_Homo sapiens_hsa00071	1.18705075
37	Complement and coagulation cascades_Homo sapiens_hsa04610	1.18320999
38	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.17884027
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.17338341
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15193274
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.13724475
42	Regulation of autophagy_Homo sapiens_hsa04140	1.12340294
43	Retinol metabolism_Homo sapiens_hsa00830	1.06963014
44	Glutathione metabolism_Homo sapiens_hsa00480	1.06738789
45	Type I diabetes mellitus_Homo sapiens_hsa04940	1.06228479
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05945910
47	Graft-versus-host disease_Homo sapiens_hsa05332	1.02450039
48	Nicotine addiction_Homo sapiens_hsa05033	1.01406697
49	Histidine metabolism_Homo sapiens_hsa00340	0.97116093
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95683808
51	Mineral absorption_Homo sapiens_hsa04978	0.94544610
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93904137
53	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89168804
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.87629521
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.86070581
56	GABAergic synapse_Homo sapiens_hsa04727	0.85748706
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84542759
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83739423
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82897547
60	Sulfur metabolism_Homo sapiens_hsa00920	0.81986855
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81930704
62	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.81405569
63	Caffeine metabolism_Homo sapiens_hsa00232	0.79025444
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.78171953
65	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.76345735
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.75801602
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.75750621
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73697570
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73492315
70	Serotonergic synapse_Homo sapiens_hsa04726	0.72734825
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71792031
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70281525
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68486803
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.67430908
75	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67192124
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.65133544
77	Metabolic pathways_Homo sapiens_hsa01100	0.64285440
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63546756
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63172561
80	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.63109098
81	Phagosome_Homo sapiens_hsa04145	0.62606827
82	Morphine addiction_Homo sapiens_hsa05032	0.60164313
83	Circadian entrainment_Homo sapiens_hsa04713	0.59299158
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58235917
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.58177687
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57742785
87	Pertussis_Homo sapiens_hsa05133	0.56184467
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53327986
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51486144
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50446608
91	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.45863251
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.43783667
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.41136199
94	Cocaine addiction_Homo sapiens_hsa05030	0.39144527
95	Circadian rhythm_Homo sapiens_hsa04710	0.37383442
96	Antigen processing and presentation_Homo sapiens_hsa04612	0.37066159
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.35482767
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.34823323
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34075693
100	Amphetamine addiction_Homo sapiens_hsa05031	0.33952811

C4ORF3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »