ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of developmental pigmentation (GO:0048087)	5.59550496
2	regulation of pigment cell differentiation (GO:0050932)	5.55602123
3	interkinetic nuclear migration (GO:0022027)	4.89309766
4	monoubiquitinated protein deubiquitination (GO:0035520)	4.75901810
5	tryptophan catabolic process (GO:0006569)	4.75406907
6	indole-containing compound catabolic process (GO:0042436)	4.75406907
7	indolalkylamine catabolic process (GO:0046218)	4.75406907
8	kynurenine metabolic process (GO:0070189)	4.69279881
9	snRNA transcription (GO:0009301)	4.52155084
10	regulation of hippo signaling (GO:0035330)	4.40974566
11	indolalkylamine metabolic process (GO:0006586)	4.37794322
12	protein K48-linked deubiquitination (GO:0071108)	4.29379524
13	signal peptide processing (GO:0006465)	4.28913001
14	regulation of establishment of cell polarity (GO:2000114)	4.21690804
15	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.00803696
16	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.00803696
17	regulation of translation, ncRNA-mediated (GO:0045974)	4.00803696
18	tryptophan metabolic process (GO:0006568)	3.96217735
19	cilium or flagellum-dependent cell motility (GO:0001539)	3.90383306
20	cellular response to ethanol (GO:0071361)	3.89919530
21	establishment of protein localization to Golgi (GO:0072600)	3.85077583
22	phospholipid translocation (GO:0045332)	3.82828521
23	lipid translocation (GO:0034204)	3.82828521
24	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.79346449
25	regulation of posttranscriptional gene silencing (GO:0060147)	3.78668230
26	regulation of gene silencing by miRNA (GO:0060964)	3.78668230
27	regulation of gene silencing by RNA (GO:0060966)	3.78668230
28	negative regulation of sodium ion transport (GO:0010766)	3.75874605
29	neural tube formation (GO:0001841)	3.68206595
30	pericardium development (GO:0060039)	3.64829120
31	flavonoid metabolic process (GO:0009812)	3.61903968
32	cytoplasmic mRNA processing body assembly (GO:0033962)	3.52110782
33	endosome to melanosome transport (GO:0035646)	3.50068558
34	endosome to pigment granule transport (GO:0043485)	3.50068558
35	behavioral response to nicotine (GO:0035095)	3.46152145
36	oxidative demethylation (GO:0070989)	3.41345554
37	glucocorticoid receptor signaling pathway (GO:0042921)	3.36477265
38	indole-containing compound metabolic process (GO:0042430)	3.34762532
39	negative regulation of protein localization to cell surface (GO:2000009)	3.31764363
40	NAD biosynthetic process (GO:0009435)	3.27290724
41	protein K63-linked deubiquitination (GO:0070536)	3.22166509
42	serotonin metabolic process (GO:0042428)	3.20338683
43	regulation of sarcomere organization (GO:0060297)	3.19205232
44	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.18880439
45	negative regulation of systemic arterial blood pressure (GO:0003085)	3.13646703
46	sulfation (GO:0051923)	3.11279275
47	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.07574884
48	protein K11-linked deubiquitination (GO:0035871)	3.04240607
49	L-fucose catabolic process (GO:0042355)	3.04063173
50	fucose catabolic process (GO:0019317)	3.04063173
51	L-fucose metabolic process (GO:0042354)	3.04063173
52	response to pheromone (GO:0019236)	3.03376991
53	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.02434753
54	striated muscle atrophy (GO:0014891)	3.01127105
55	cardiovascular system development (GO:0072358)	2.99732049
56	reflex (GO:0060004)	2.94828949
57	detection of light stimulus involved in sensory perception (GO:0050962)	2.93911533
58	detection of light stimulus involved in visual perception (GO:0050908)	2.93911533
59	nucleus localization (GO:0051647)	2.92647895
60	protein targeting to vacuole (GO:0006623)	2.91655398
61	protein targeting to lysosome (GO:0006622)	2.91655398
62	establishment of protein localization to vacuole (GO:0072666)	2.91655398
63	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.90989083
64	primary amino compound metabolic process (GO:1901160)	2.89385770
65	cellular response to sterol (GO:0036315)	2.83944355
66	regulation of developmental pigmentation (GO:0048070)	2.83417508
67	cellular ketone body metabolic process (GO:0046950)	2.79703975
68	thyroid hormone metabolic process (GO:0042403)	2.77619061
69	gamma-aminobutyric acid transport (GO:0015812)	2.76777503
70	corticosteroid receptor signaling pathway (GO:0031958)	2.76441544
71	endocardial cushion development (GO:0003197)	2.76375533
72	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.71860822
73	photoreceptor cell maintenance (GO:0045494)	2.70420236
74	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.69643561
75	positive regulation of CREB transcription factor activity (GO:0032793)	2.69530020
76	sphingoid metabolic process (GO:0046519)	2.69293507
77	skeletal muscle adaptation (GO:0043501)	2.68066505
78	histone-serine phosphorylation (GO:0035404)	2.64742549
79	negative regulation of keratinocyte proliferation (GO:0010839)	2.62873945
80	histone H3-K9 methylation (GO:0051567)	2.61346176
81	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.60342015
82	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.57902347
83	appendage development (GO:0048736)	2.57092140
84	limb development (GO:0060173)	2.57092140
85	benzene-containing compound metabolic process (GO:0042537)	2.53835990
86	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.51791234
87	microtubule anchoring (GO:0034453)	2.50865404
88	spinal cord motor neuron differentiation (GO:0021522)	2.50617267
89	amine catabolic process (GO:0009310)	2.49831851
90	cellular biogenic amine catabolic process (GO:0042402)	2.49831851
91	histone H3-K4 trimethylation (GO:0080182)	2.49830410
92	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.49566410
93	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.48722069
94	negative regulation of mast cell activation (GO:0033004)	2.48112459
95	central nervous system neuron axonogenesis (GO:0021955)	2.47684826
96	membrane depolarization during action potential (GO:0086010)	2.46542268
97	muscle atrophy (GO:0014889)	2.45554387
98	ketone body metabolic process (GO:1902224)	2.44753941
99	cAMP catabolic process (GO:0006198)	2.44061236
100	peptidyl-lysine methylation (GO:0018022)	2.42362001

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.32368128
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.00450408
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.76560021
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.70168250
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.57266312
6	VDR_22108803_ChIP-Seq_LS180_Human	2.53318422
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.44880453
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41322791
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.30949369
10	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.29964014
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.22758572
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.22353625
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.16607673
14	AR_21572438_ChIP-Seq_LNCaP_Human	2.06825989
15	STAT3_23295773_ChIP-Seq_U87_Human	2.06619820
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.02021417
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.00152263
18	TP53_16413492_ChIP-PET_HCT116_Human	1.98635728
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.92478524
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90610976
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.86949066
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86455459
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85373196
24	* P300_19829295_ChIP-Seq_ESCs_Human	1.83495828
25	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.80404064
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.78111529
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76015224
28	TCF4_23295773_ChIP-Seq_U87_Human	1.75572312
29	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.72727317
30	FUS_26573619_Chip-Seq_HEK293_Human	1.71378533
31	* EWS_26573619_Chip-Seq_HEK293_Human	1.70450838
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.68325817
33	AHR_22903824_ChIP-Seq_MCF-7_Human	1.68094523
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.61972558
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61972558
36	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.61402697
37	* ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.60636916
38	DROSHA_22980978_ChIP-Seq_HELA_Human	1.60582052
39	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.59281964
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58567381
41	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.57098960
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52675366
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50076525
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48884841
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.48623357
46	AR_25329375_ChIP-Seq_VCAP_Human	1.48377863
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.48262396
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45851919
49	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.41619779
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.41592230
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41592230
52	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.40914172
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31947055
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31570241
55	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30306347
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.27145131
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26196072
58	RXR_22108803_ChIP-Seq_LS180_Human	1.26149659
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25575218
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24201258
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24068862
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22612174
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21159561
64	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20748237
65	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.19837254
66	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.18036459
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17752949
68	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.16522925
69	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.16419534
70	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15867354
71	KDM2B_26808549_Chip-Seq_REH_Human	1.15032982
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14962080
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14678346
74	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.13102581
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12579823
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12540576
77	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.11965350
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10487412
79	CJUN_26792858_Chip-Seq_BT549_Human	1.10041591
80	AR_19668381_ChIP-Seq_PC3_Human	1.08974923
81	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.08103632
82	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.08103632
83	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07844967
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06209486
85	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06139614
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06064932
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05766620
88	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.04338240
89	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03569029
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.03154089
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02917519
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02480601
93	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00918772
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00369886
95	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.99971577
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99562211
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98498470
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98254010
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97241482
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97241482

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.72429826
2	MP0008057_abnormal_DNA_replication	5.03399186
3	MP0003646_muscle_fatigue	4.08253417
4	MP0003195_calcinosis	3.84914222
5	MP0004043_abnormal_pH_regulation	3.00076663
6	MP0003890_abnormal_embryonic-extraembry	2.62229638
7	MP0003045_fibrosis	2.59906616
8	MP0009046_muscle_twitch	2.59769009
9	MP0001501_abnormal_sleep_pattern	2.43658388
10	MP0004130_abnormal_muscle_cell	2.42109002
11	MP0008961_abnormal_basal_metabolism	2.37276801
12	MP0000383_abnormal_hair_follicle	2.33888928
13	MP0000427_abnormal_hair_cycle	2.32832638
14	MP0003136_yellow_coat_color	2.25381783
15	MP0002837_dystrophic_cardiac_calcinosis	2.09596279
16	MP0005670_abnormal_white_adipose	2.03370890
17	MP0005551_abnormal_eye_electrophysiolog	1.99420371
18	MP0004145_abnormal_muscle_electrophysio	1.71293190
19	MP0005171_absent_coat_pigmentation	1.62257785
20	MP0001968_abnormal_touch/_nociception	1.61770100
21	MP0002168_other_aberrant_phenotype	1.61489096
22	MP0005174_abnormal_tail_pigmentation	1.57599429
23	MP0003950_abnormal_plasma_membrane	1.55921771
24	MP0009745_abnormal_behavioral_response	1.51440255
25	MP0005266_abnormal_metabolism	1.47309822
26	MP0004142_abnormal_muscle_tone	1.45735443
27	MP0002138_abnormal_hepatobiliary_system	1.40140510
28	MP0001485_abnormal_pinna_reflex	1.38658322
29	MP0002009_preneoplasia	1.36613672
30	MP0005386_behavior/neurological_phenoty	1.35858510
31	MP0004924_abnormal_behavior	1.35858510
32	MP0002928_abnormal_bile_duct	1.34718888
33	MP0002735_abnormal_chemical_nociception	1.31456510
34	MP0003252_abnormal_bile_duct	1.29258313
35	MP0010386_abnormal_urinary_bladder	1.27975854
36	MP0005310_abnormal_salivary_gland	1.27802907
37	MP0002876_abnormal_thyroid_physiology	1.26878998
38	MP0005646_abnormal_pituitary_gland	1.26303559
39	MP0001486_abnormal_startle_reflex	1.26282770
40	MP0002064_seizures	1.25629296
41	MP0000538_abnormal_urinary_bladder	1.23853807
42	MP0002736_abnormal_nociception_after	1.23133839
43	MP0005253_abnormal_eye_physiology	1.20087072
44	MP0010678_abnormal_skin_adnexa	1.19759913
45	MP0009115_abnormal_fat_cell	1.18762092
46	MP0008872_abnormal_physiological_respon	1.18214117
47	MP0002653_abnormal_ependyma_morphology	1.16288941
48	MP0005645_abnormal_hypothalamus_physiol	1.15486222
49	MP0004215_abnormal_myocardial_fiber	1.12879903
50	MP0002067_abnormal_sensory_capabilities	1.12566653
51	MP0008877_abnormal_DNA_methylation	1.12224549
52	MP0005167_abnormal_blood-brain_barrier	1.10636056
53	MP0002272_abnormal_nervous_system	1.10593034
54	MP0002572_abnormal_emotion/affect_behav	1.08826214
55	MP0002638_abnormal_pupillary_reflex	1.06584267
56	MP0002332_abnormal_exercise_endurance	1.05147521
57	MP0005085_abnormal_gallbladder_physiolo	1.03381881
58	MP0006276_abnormal_autonomic_nervous	0.99950556
59	MP0002938_white_spotting	0.99890833
60	MP0000230_abnormal_systemic_arterial	0.99648401
61	MP0004381_abnormal_hair_follicle	0.97755025
62	MP0005448_abnormal_energy_balance	0.97271311
63	MP0003937_abnormal_limbs/digits/tail_de	0.96442242
64	MP0005187_abnormal_penis_morphology	0.95965932
65	MP0000371_diluted_coat_color	0.95807771
66	MP0005395_other_phenotype	0.95771291
67	MP0003879_abnormal_hair_cell	0.93124822
68	MP0000631_abnormal_neuroendocrine_gland	0.92228325
69	MP0003635_abnormal_synaptic_transmissio	0.91401689
70	MP0002095_abnormal_skin_pigmentation	0.88388539
71	MP0002557_abnormal_social/conspecific_i	0.88229075
72	MP0000470_abnormal_stomach_morphology	0.87704409
73	MP0003137_abnormal_impulse_conducting	0.87340179
74	MP0001970_abnormal_pain_threshold	0.87286589
75	MP0002063_abnormal_learning/memory/cond	0.86412878
76	MP0003119_abnormal_digestive_system	0.84657597
77	MP0003632_abnormal_nervous_system	0.84576547
78	MP0004147_increased_porphyrin_level	0.81511979
79	MP0003633_abnormal_nervous_system	0.81474643
80	MP0004084_abnormal_cardiac_muscle	0.81106191
81	MP0002102_abnormal_ear_morphology	0.81094592
82	MP0003943_abnormal_hepatobiliary_system	0.78268554
83	MP0003878_abnormal_ear_physiology	0.76992452
84	MP0005377_hearing/vestibular/ear_phenot	0.76992452
85	MP0003631_nervous_system_phenotype	0.76694752
86	MP0003787_abnormal_imprinting	0.76509257
87	MP0002733_abnormal_thermal_nociception	0.75969900
88	MP0006054_spinal_hemorrhage	0.72260349
89	MP0001879_abnormal_lymphatic_vessel	0.72182209
90	MP0002229_neurodegeneration	0.71494185
91	MP0002160_abnormal_reproductive_system	0.71069058
92	MP0005195_abnormal_posterior_eye	0.69708366
93	MP0010329_abnormal_lipoprotein_level	0.68862541
94	MP0003959_abnormal_lean_body	0.68588474
95	MP0004085_abnormal_heartbeat	0.68090185
96	MP0000778_abnormal_nervous_system	0.63922176
97	MP0001324_abnormal_eye_pigmentation	0.63824019
98	MP0008775_abnormal_heart_ventricle	0.62799721
99	MP0005647_abnormal_sex_gland	0.61497654
100	MP0001984_abnormal_olfaction	0.60842643

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	6.16839145
2	Hyperventilation (HP:0002883)	4.82175345
3	Progressive cerebellar ataxia (HP:0002073)	4.40538860
4	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	4.35122806
5	Pancreatic cysts (HP:0001737)	4.25044050
6	Protruding tongue (HP:0010808)	4.13486971
7	Gaze-evoked nystagmus (HP:0000640)	4.03638327
8	Clumsiness (HP:0002312)	3.95927897
9	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.73493678
10	Pancreatic fibrosis (HP:0100732)	3.53191498
11	True hermaphroditism (HP:0010459)	3.37161608
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.34134234
13	Chronic hepatic failure (HP:0100626)	3.28416383
14	Birth length less than 3rd percentile (HP:0003561)	3.21892959
15	Fair hair (HP:0002286)	3.18692309
16	Dysmetric saccades (HP:0000641)	3.10195516
17	Abnormality of the renal cortex (HP:0011035)	3.01921010
18	Cystic liver disease (HP:0006706)	2.96158644
19	Molar tooth sign on MRI (HP:0002419)	2.94513343
20	Abnormality of midbrain morphology (HP:0002418)	2.94513343
21	Increased cerebral lipofuscin (HP:0011813)	2.83503559
22	Attenuation of retinal blood vessels (HP:0007843)	2.82130410
23	Patellar aplasia (HP:0006443)	2.80684035
24	Febrile seizures (HP:0002373)	2.78531142
25	Congenital stationary night blindness (HP:0007642)	2.78474363
26	Abnormality of the renal medulla (HP:0100957)	2.78132965
27	Nephronophthisis (HP:0000090)	2.75507953
28	Hypoplastic ischia (HP:0003175)	2.61277673
29	Hypoplastic labia majora (HP:0000059)	2.59179859
30	Tubular atrophy (HP:0000092)	2.59130681
31	Abnormality of the ischium (HP:0003174)	2.54338162
32	Aplasia/Hypoplasia of the patella (HP:0006498)	2.52437717
33	Generalized hypopigmentation of hair (HP:0011358)	2.52353404
34	Decreased circulating renin level (HP:0003351)	2.52197803
35	Hyperalaninemia (HP:0003348)	2.51802410
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51802410
37	Abnormality of alanine metabolism (HP:0010916)	2.51802410
38	Abnormality of the labia majora (HP:0012881)	2.46009645
39	Broad-based gait (HP:0002136)	2.45240741
40	Preaxial foot polydactyly (HP:0001841)	2.43443707
41	Widely spaced teeth (HP:0000687)	2.41721360
42	Large for gestational age (HP:0001520)	2.40239253
43	Inability to walk (HP:0002540)	2.38181951
44	Furrowed tongue (HP:0000221)	2.36551264
45	Progressive inability to walk (HP:0002505)	2.34620675
46	Absent speech (HP:0001344)	2.33740083
47	Dialeptic seizures (HP:0011146)	2.27072304
48	Congenital sensorineural hearing impairment (HP:0008527)	2.22954396
49	Absent radius (HP:0003974)	2.15332793
50	Bony spicule pigmentary retinopathy (HP:0007737)	2.15235476
51	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.14836455
52	Urinary bladder sphincter dysfunction (HP:0002839)	2.14132988
53	Medial flaring of the eyebrow (HP:0010747)	2.10639520
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09377910
55	Cerebellar dysplasia (HP:0007033)	2.08920408
56	Congenital hepatic fibrosis (HP:0002612)	2.06727916
57	Aplasia involving forearm bones (HP:0009822)	2.06255047
58	Absent forearm bone (HP:0003953)	2.06255047
59	Central scotoma (HP:0000603)	2.04942348
60	Amelogenesis imperfecta (HP:0000705)	2.02629112
61	Abnormality of binocular vision (HP:0011514)	2.01977076
62	Diplopia (HP:0000651)	2.01977076
63	Tracheomalacia (HP:0002779)	2.01043536
64	Absent/shortened dynein arms (HP:0200106)	1.99785361
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99785361
66	Bronchomalacia (HP:0002780)	1.98162838
67	Absence seizures (HP:0002121)	1.97912496
68	Duplicated collecting system (HP:0000081)	1.96232928
69	Hyperkalemia (HP:0002153)	1.95068692
70	Focal seizures (HP:0007359)	1.94707531
71	Abnormality of the renal collecting system (HP:0004742)	1.94316088
72	Stomach cancer (HP:0012126)	1.93207990
73	Impaired smooth pursuit (HP:0007772)	1.92813837
74	Clubbing of toes (HP:0100760)	1.89265886
75	Short foot (HP:0001773)	1.89217118
76	Poor coordination (HP:0002370)	1.86489464
77	Truncal obesity (HP:0001956)	1.85931149
78	Abnormality of the nasal septum (HP:0000419)	1.83684729
79	Polydipsia (HP:0001959)	1.83061465
80	Abnormal drinking behavior (HP:0030082)	1.83061465
81	Chromsome breakage (HP:0040012)	1.81620686
82	Abolished electroretinogram (ERG) (HP:0000550)	1.81452137
83	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.81390717
84	Abnormality of the fingertips (HP:0001211)	1.80774390
85	Hypoplastic iliac wings (HP:0002866)	1.80651241
86	Chorioretinal atrophy (HP:0000533)	1.79315609
87	Gait imbalance (HP:0002141)	1.78873268
88	Highly arched eyebrow (HP:0002553)	1.78498460
89	Congenital primary aphakia (HP:0007707)	1.76669893
90	Bulbous nose (HP:0000414)	1.76600277
91	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75024371
92	Macroglossia (HP:0000158)	1.74969792
93	Short chin (HP:0000331)	1.74931463
94	Anencephaly (HP:0002323)	1.73290813
95	Hypoplasia of the pons (HP:0012110)	1.72723419
96	Tented upper lip vermilion (HP:0010804)	1.71533758
97	Type II lissencephaly (HP:0007260)	1.71310438
98	Small hand (HP:0200055)	1.70590189
99	Facial diplegia (HP:0001349)	1.70360915
100	Genital tract atresia (HP:0001827)	1.70025753

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.70119417
2	BMPR1B	3.62658866
3	AKT3	2.36079750
4	LATS1	2.06339537
5	FRK	10.2753564
6	MKNK2	1.87319293
7	ADRBK2	1.84944718
8	INSRR	1.79657623
9	STK38L	1.75804906
10	CDK12	1.66069593
11	TGFBR1	1.63298663
12	CAMK1D	1.60031253
13	CAMK1G	1.55952611
14	ADRBK1	1.31684890
15	TAOK3	1.31051849
16	MELK	1.29436781
17	GRK1	1.23354307
18	CASK	1.22173441
19	PIK3CG	1.20606607
20	BRD4	1.20071982
21	TRPM7	1.17125352
22	MAPK13	1.12489322
23	OXSR1	1.10176418
24	NLK	1.09101593
25	ZAK	1.07145562
26	NTRK3	1.05492531
27	PIK3CA	1.04840101
28	SGK2	1.03256169
29	PRKAA2	1.00460481
30	STK39	0.99910855
31	CAMKK2	0.98810437
32	MAP3K7	0.98644779
33	MAP3K4	0.97722373
34	WNK3	0.96114149
35	STK38	0.93885162
36	BRSK2	0.87724266
37	WNK4	0.86427627
38	STK3	0.82759258
39	PNCK	0.81363171
40	NUAK1	0.80795085
41	DAPK2	0.80572347
42	TEC	0.77959471
43	PTK2B	0.75747689
44	CHUK	0.74945675
45	OBSCN	0.69902562
46	WNK1	0.69811893
47	TNIK	0.64387527
48	SIK2	0.60140265
49	MKNK1	0.59723240
50	CAMK1	0.59498020
51	SGK223	0.57951476
52	SGK494	0.57951476
53	NEK2	0.57155832
54	CAMK4	0.57012488
55	STK11	0.55263108
56	PRKAA1	0.54942728
57	MAP2K1	0.54054491
58	FER	0.53396348
59	PAK3	0.53090282
60	PRKCE	0.50794460
61	ERBB2	0.49258977
62	TLK1	0.47903108
63	MAPK11	0.47105467
64	TNK2	0.46793185
65	PINK1	0.46045866
66	SGK3	0.45112666
67	RPS6KA6	0.44061265
68	PDGFRB	0.40947589
69	MAPKAPK3	0.40685260
70	BLK	0.40142339
71	FGFR2	0.39222962
72	IRAK1	0.39197154
73	PRKCG	0.39086032
74	SGK1	0.38528210
75	MARK1	0.36861489
76	CAMK2A	0.36651512
77	MET	0.35747125
78	CAMKK1	0.35159422
79	TXK	0.34984551
80	CSNK1D	0.34734443
81	PKN1	0.34082931
82	PRKCH	0.34049373
83	IKBKB	0.32917387
84	KIT	0.32887963
85	MTOR	0.32597753
86	ITK	0.31757556
87	EEF2K	0.31559167
88	CSNK1A1L	0.31523134
89	MARK2	0.31478401
90	CDC42BPA	0.30173985
91	RPS6KA3	0.29023669
92	MAP3K2	0.28955520
93	MAPK7	0.28160100
94	GSK3B	0.28093733
95	TIE1	0.27859945
96	MAPK8	0.27420418
97	CDK3	0.27009027
98	CHEK2	0.26325053
99	MAPK1	0.24435065
100	AKT1	0.24002004

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ABC transporters_Homo sapiens_hsa02010	2.50538513
2	Nicotine addiction_Homo sapiens_hsa05033	2.48040258
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.13750522
4	Phototransduction_Homo sapiens_hsa04744	2.13102650
5	Butanoate metabolism_Homo sapiens_hsa00650	2.02810989
6	Tryptophan metabolism_Homo sapiens_hsa00380	1.98846327
7	Taste transduction_Homo sapiens_hsa04742	1.98209884
8	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88504821
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87503409
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.86928126
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.86221351
12	Lysine degradation_Homo sapiens_hsa00310	1.84692462
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75170176
14	Morphine addiction_Homo sapiens_hsa05032	1.66439273
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61056028
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49590672
17	Histidine metabolism_Homo sapiens_hsa00340	1.49456180
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.49144251
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.42877791
20	Circadian entrainment_Homo sapiens_hsa04713	1.40121254
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39404079
22	Homologous recombination_Homo sapiens_hsa03440	1.35951577
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.35115816
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.35018865
25	Glycerolipid metabolism_Homo sapiens_hsa00561	1.30509182
26	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.30089494
27	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.27535357
28	Serotonergic synapse_Homo sapiens_hsa04726	1.26689198
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26540790
30	Olfactory transduction_Homo sapiens_hsa04740	1.19460523
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.17703859
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16238135
33	GABAergic synapse_Homo sapiens_hsa04727	1.15292283
34	Salivary secretion_Homo sapiens_hsa04970	1.12220621
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12002819
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10876886
37	Type II diabetes mellitus_Homo sapiens_hsa04930	1.06310212
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06079293
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03786197
40	Circadian rhythm_Homo sapiens_hsa04710	1.03428513
41	Insulin secretion_Homo sapiens_hsa04911	1.00990848
42	Cholinergic synapse_Homo sapiens_hsa04725	1.00229148
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.99638674
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98207104
45	Long-term depression_Homo sapiens_hsa04730	0.95236908
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.95226785
47	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.91838239
48	Gastric acid secretion_Homo sapiens_hsa04971	0.84349262
49	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.83384635
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80432958
51	FoxO signaling pathway_Homo sapiens_hsa04068	0.80192543
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80180309
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.79671688
54	Caffeine metabolism_Homo sapiens_hsa00232	0.78026181
55	Retinol metabolism_Homo sapiens_hsa00830	0.77859670
56	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76606886
57	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75549887
58	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.73650507
59	Renin secretion_Homo sapiens_hsa04924	0.71111987
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70896521
61	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.69292635
62	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.68659718
63	Platelet activation_Homo sapiens_hsa04611	0.67462491
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.66325117
65	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.66220061
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62392604
67	Pancreatic secretion_Homo sapiens_hsa04972	0.61873313
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.60288222
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60126651
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57944501
71	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.57706395
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.57494265
73	Choline metabolism in cancer_Homo sapiens_hsa05231	0.56868697
74	Bile secretion_Homo sapiens_hsa04976	0.56512651
75	Graft-versus-host disease_Homo sapiens_hsa05332	0.56251743
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55255308
77	Melanoma_Homo sapiens_hsa05218	0.55076500
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.54268234
79	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.53337139
80	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.52829184
81	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52154602
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51664768
83	MAPK signaling pathway_Homo sapiens_hsa04010	0.51403638
84	Insulin resistance_Homo sapiens_hsa04931	0.50230522
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49761366
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48797061
87	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.48784515
88	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.48701502
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48656632
90	Estrogen signaling pathway_Homo sapiens_hsa04915	0.48114252
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46636687
92	Ras signaling pathway_Homo sapiens_hsa04014	0.46299478
93	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.46219075
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43930953
95	Asthma_Homo sapiens_hsa05310	0.43008881
96	MicroRNAs in cancer_Homo sapiens_hsa05206	0.42525606
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.41238656
98	Propanoate metabolism_Homo sapiens_hsa00640	0.39646682
99	Cocaine addiction_Homo sapiens_hsa05030	0.38581855
100	Prolactin signaling pathway_Homo sapiens_hsa04917	0.38453967

C4ORF32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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