ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neutrophil activation involved in immune response (GO:0002283)	4.11461568
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.85858085
3	respiratory chain complex IV assembly (GO:0008535)	3.63506059
4	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.54448235
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.50901764
6	cellular ketone body metabolic process (GO:0046950)	3.49090632
7	respiratory electron transport chain (GO:0022904)	3.45340394
8	electron transport chain (GO:0022900)	3.43729361
9	cytochrome complex assembly (GO:0017004)	3.40682824
10	protein prenylation (GO:0018342)	3.40449431
11	prenylation (GO:0097354)	3.40449431
12	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.38366789
13	protein complex biogenesis (GO:0070271)	3.33435066
14	protein neddylation (GO:0045116)	3.24671404
15	nucleobase catabolic process (GO:0046113)	3.23511277
16	platelet dense granule organization (GO:0060155)	3.23390054
17	regulation of hexokinase activity (GO:1903299)	3.16353868
18	regulation of glucokinase activity (GO:0033131)	3.16353868
19	pyrimidine nucleobase catabolic process (GO:0006208)	3.13262567
20	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.11691712
21	protein localization to cilium (GO:0061512)	3.11649546
22	ketone body metabolic process (GO:1902224)	3.11046705
23	neural tube formation (GO:0001841)	3.10814265
24	ATP synthesis coupled proton transport (GO:0015986)	3.07719399
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.07719399
26	axoneme assembly (GO:0035082)	2.97019060
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.91945716
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.91945716
29	NADH dehydrogenase complex assembly (GO:0010257)	2.91945716
30	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91023834
31	anterograde synaptic vesicle transport (GO:0048490)	2.90239188
32	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.86493936
33	tryptophan catabolic process (GO:0006569)	2.81901948
34	indole-containing compound catabolic process (GO:0042436)	2.81901948
35	indolalkylamine catabolic process (GO:0046218)	2.81901948
36	positive regulation of mast cell activation (GO:0033005)	2.80115835
37	epithelial cilium movement (GO:0003351)	2.77234171
38	immunoglobulin mediated immune response (GO:0016064)	2.77150471
39	magnesium ion transport (GO:0015693)	2.73984969
40	neutrophil activation (GO:0042119)	2.72283398
41	xenobiotic catabolic process (GO:0042178)	2.68899955
42	proton transport (GO:0015992)	2.65357354
43	indolalkylamine metabolic process (GO:0006586)	2.63622678
44	sequestering of actin monomers (GO:0042989)	2.63271687
45	negative regulation of membrane potential (GO:0045837)	2.62960651
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.62636987
47	hydrogen ion transmembrane transport (GO:1902600)	2.61990242
48	regulation of cilium movement (GO:0003352)	2.59806336
49	hydrogen transport (GO:0006818)	2.59271497
50	tryptophan metabolic process (GO:0006568)	2.59256793
51	regulation of inflammatory response to antigenic stimulus (GO:0002861)	2.52560373
52	cilium movement (GO:0003341)	2.51486363
53	regulation of hypersensitivity (GO:0002883)	2.48584376
54	granulocyte activation (GO:0036230)	2.47471855
55	regulation of mast cell activation (GO:0033003)	2.46307040
56	T-helper 1 type immune response (GO:0042088)	2.44917114
57	glycosphingolipid biosynthetic process (GO:0006688)	2.43641245
58	negative regulation of mast cell activation (GO:0033004)	2.41896243
59	positive regulation of amino acid transport (GO:0051957)	2.41658865
60	positive regulation of heat generation (GO:0031652)	2.41624497
61	adenosine metabolic process (GO:0046085)	2.40400269
62	cytidine metabolic process (GO:0046087)	2.39333685
63	cytidine catabolic process (GO:0006216)	2.39333685
64	cytidine deamination (GO:0009972)	2.39333685
65	cellular biogenic amine catabolic process (GO:0042402)	2.38314317
66	amine catabolic process (GO:0009310)	2.38314317
67	regulation of heat generation (GO:0031650)	2.37836906
68	histamine secretion (GO:0001821)	2.36944389
69	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.36122407
70	positive regulation of mast cell degranulation (GO:0043306)	2.36122407
71	oligosaccharide catabolic process (GO:0009313)	2.35926164
72	DNA deamination (GO:0045006)	2.35316628
73	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.33340764
74	negative regulation of acute inflammatory response (GO:0002674)	2.31112242
75	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.30512817
76	centriole replication (GO:0007099)	2.30170935
77	negative regulation of heart rate (GO:0010459)	2.28857058
78	regulation of fever generation (GO:0031620)	2.28551252
79	peroxisome fission (GO:0016559)	2.27877301
80	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	2.27600849
81	ribonucleoprotein complex disassembly (GO:0032988)	2.27476574
82	B cell mediated immunity (GO:0019724)	2.26181306
83	phagosome maturation (GO:0090382)	2.24811998
84	succinate metabolic process (GO:0006105)	2.22225773
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.21116538
86	organelle disassembly (GO:1903008)	2.19408172
87	response to pheromone (GO:0019236)	2.18905171
88	neutrophil mediated immunity (GO:0002446)	2.18665921
89	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.18286926
90	ATP hydrolysis coupled proton transport (GO:0015991)	2.18286926
91	proteasome assembly (GO:0043248)	2.18226674
92	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.17677334
93	intraciliary transport (GO:0042073)	2.17169588
94	ubiquinone biosynthetic process (GO:0006744)	2.16961029
95	regulation of feeding behavior (GO:0060259)	2.16669039
96	microglial cell activation (GO:0001774)	2.16194573
97	dopamine transport (GO:0015872)	2.16158126
98	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.15233454
99	ubiquinone metabolic process (GO:0006743)	2.14953188
100	C-terminal protein lipidation (GO:0006501)	2.13703166

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.17051112
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.88073965
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.86272571
4	* TAF15_26573619_Chip-Seq_HEK293_Human	2.62974803
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.53023138
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47557710
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36635262
8	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.31201060
9	VDR_22108803_ChIP-Seq_LS180_Human	2.30718090
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.26299666
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.25985098
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.23126505
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20196793
14	FUS_26573619_Chip-Seq_HEK293_Human	2.17002628
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15738087
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10605595
17	P300_19829295_ChIP-Seq_ESCs_Human	2.06600003
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05868569
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.03160717
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.96155598
21	* EWS_26573619_Chip-Seq_HEK293_Human	1.94382416
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.94307840
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.88617333
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78826218
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.77741534
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.65313752
27	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65299728
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64548353
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62481976
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62279237
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62258611
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61251128
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60508344
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.53890346
35	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.52991538
36	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52298697
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51926524
38	* VDR_23849224_ChIP-Seq_CD4+_Human	1.50844042
39	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.49515892
40	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45540849
41	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.45222912
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45117260
43	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.43953595
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43863620
45	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.43094126
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42140858
47	P53_22387025_ChIP-Seq_ESCs_Mouse	1.41297776
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39879849
49	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36018705
50	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.34667999
51	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33553153
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32644717
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32644717
54	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.31323967
55	* AR_25329375_ChIP-Seq_VCAP_Human	1.30167576
56	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.30142027
57	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.28549533
58	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.28411425
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.27567809
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27567809
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.27414478
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.25900789
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23526148
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.22371191
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22239676
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.21862600
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21849101
68	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.21623206
69	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21056466
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20782376
71	P300_18555785_Chip-Seq_ESCs_Mouse	1.20227942
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19916944
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19916944
74	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.16761742
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16749357
76	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.16325290
77	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15719819
78	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13623511
79	GATA1_22025678_ChIP-Seq_K562_Human	1.13170394
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12961997
81	STAT3_23295773_ChIP-Seq_U87_Human	1.11603310
82	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11301935
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09989632
84	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.09683090
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09672117
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08874334
87	AR_20517297_ChIP-Seq_VCAP_Human	1.07542351
88	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.07474120
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06285293
90	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.05974131
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05461224
92	TCF4_22108803_ChIP-Seq_LS180_Human	1.05446369
93	GATA3_26560356_Chip-Seq_TH2_Human	1.04956137
94	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.04696481
95	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04035348
96	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03514917
97	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.02944906
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02803520
99	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02708058
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02480633

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003724_increased_susceptibility_to	3.09226384
2	MP0008877_abnormal_DNA_methylation	2.55696600
3	MP0003787_abnormal_imprinting	2.45612242
4	MP0000569_abnormal_digit_pigmentation	2.42624146
5	MP0001835_abnormal_antigen_presentation	2.41126694
6	MP0006082_CNS_inflammation	2.28017897
7	MP0002139_abnormal_hepatobiliary_system	2.22981914
8	MP0003195_calcinosis	2.08558205
9	MP0005084_abnormal_gallbladder_morpholo	1.94774026
10	MP0010386_abnormal_urinary_bladder	1.93349739
11	MP0002837_dystrophic_cardiac_calcinosis	1.93142423
12	MP0006036_abnormal_mitochondrial_physio	1.91333583
13	MP0005645_abnormal_hypothalamus_physiol	1.86907896
14	MP0009785_altered_susceptibility_to	1.80418313
15	MP0005671_abnormal_response_to	1.78620902
16	MP0009046_muscle_twitch	1.76289886
17	MP0005379_endocrine/exocrine_gland_phen	1.68230321
18	MP0002163_abnormal_gland_morphology	1.64429803
19	MP0002909_abnormal_adrenal_gland	1.63807096
20	MP0001529_abnormal_vocalization	1.62130651
21	MP0003806_abnormal_nucleotide_metabolis	1.53344309
22	MP0002735_abnormal_chemical_nociception	1.50940202
23	MP0006072_abnormal_retinal_apoptosis	1.50097303
24	MP0003303_peritoneal_inflammation	1.49942191
25	MP0002638_abnormal_pupillary_reflex	1.49705849
26	MP0004142_abnormal_muscle_tone	1.45907631
27	MP0008872_abnormal_physiological_respon	1.45099268
28	MP0002822_catalepsy	1.43377348
29	MP0002102_abnormal_ear_morphology	1.40069050
30	MP0003880_abnormal_central_pattern	1.38238547
31	MP0004043_abnormal_pH_regulation	1.35097233
32	MP0002693_abnormal_pancreas_physiology	1.32083118
33	MP0008995_early_reproductive_senescence	1.30919614
34	MP0006035_abnormal_mitochondrial_morpho	1.30219811
35	MP0005367_renal/urinary_system_phenotyp	1.30070786
36	MP0000516_abnormal_urinary_system	1.30070786
37	MP0002148_abnormal_hypersensitivity_rea	1.29094779
38	MP0002277_abnormal_respiratory_mucosa	1.27990685
39	MP0009764_decreased_sensitivity_to	1.27673311
40	MP0005000_abnormal_immune_tolerance	1.26359712
41	MP0009745_abnormal_behavioral_response	1.26253166
42	MP0002090_abnormal_vision	1.25603764
43	MP0001800_abnormal_humoral_immune	1.25522018
44	MP0010234_abnormal_vibrissa_follicle	1.24938088
45	MP0005535_abnormal_body_temperature	1.23576202
46	MP0003121_genomic_imprinting	1.22838666
47	MP0002272_abnormal_nervous_system	1.19367158
48	MP0003656_abnormal_erythrocyte_physiolo	1.16419926
49	MP0005025_abnormal_response_to	1.16028648
50	MP0001970_abnormal_pain_threshold	1.14144893
51	MP0001986_abnormal_taste_sensitivity	1.13995329
52	MP0002419_abnormal_innate_immunity	1.13844042
53	MP0001905_abnormal_dopamine_level	1.13655484
54	MP0005253_abnormal_eye_physiology	1.11814737
55	MP0005075_abnormal_melanosome_morpholog	1.11658586
56	MP0002452_abnormal_antigen_presenting	1.09725531
57	MP0001790_abnormal_immune_system	1.09544767
58	MP0005387_immune_system_phenotype	1.09544767
59	MP0002723_abnormal_immune_serum	1.09169251
60	MP0001440_abnormal_grooming_behavior	1.07423633
61	MP0002733_abnormal_thermal_nociception	1.07021213
62	MP0005464_abnormal_platelet_physiology	1.06256120
63	MP0005266_abnormal_metabolism	1.06182712
64	MP0001501_abnormal_sleep_pattern	1.04011196
65	MP0002876_abnormal_thyroid_physiology	1.03796939
66	MP0008875_abnormal_xenobiotic_pharmacok	1.02951622
67	MP0005646_abnormal_pituitary_gland	1.02416707
68	MP0005636_abnormal_mineral_homeostasis	1.01103955
69	MP0001727_abnormal_embryo_implantation	1.00639228
70	MP0004147_increased_porphyrin_level	0.99103528
71	MP0001984_abnormal_olfaction	0.98148941
72	MP0002064_seizures	0.97881274
73	MP0002332_abnormal_exercise_endurance	0.97869430
74	MP0002928_abnormal_bile_duct	0.97172007
75	MP0005551_abnormal_eye_electrophysiolog	0.96784985
76	MP0003633_abnormal_nervous_system	0.95750837
77	MP0000465_gastrointestinal_hemorrhage	0.95600676
78	MP0001845_abnormal_inflammatory_respons	0.94780575
79	MP0006276_abnormal_autonomic_nervous	0.92275101
80	MP0005310_abnormal_salivary_gland	0.92009515
81	MP0000685_abnormal_immune_system	0.90826316
82	MP0005423_abnormal_somatic_nervous	0.89214421
83	MP0005085_abnormal_gallbladder_physiolo	0.88953866
84	MP0001485_abnormal_pinna_reflex	0.88261762
85	MP0000372_irregular_coat_pigmentation	0.87919484
86	MP0005332_abnormal_amino_acid	0.86504134
87	MP0002420_abnormal_adaptive_immunity	0.86347892
88	MP0001819_abnormal_immune_cell	0.86341938
89	MP0001486_abnormal_startle_reflex	0.86013115
90	MP0003252_abnormal_bile_duct	0.85675067
91	MP0004924_abnormal_behavior	0.84382934
92	MP0005386_behavior/neurological_phenoty	0.84382934
93	MP0002067_abnormal_sensory_capabilities	0.83483961
94	MP0005174_abnormal_tail_pigmentation	0.81919882
95	MP0003718_maternal_effect	0.81374978
96	MP0004270_analgesia	0.80560066
97	MP0001968_abnormal_touch/_nociception	0.79954339
98	MP0004215_abnormal_myocardial_fiber	0.79168515
99	MP0008469_abnormal_protein_level	0.77668190
100	MP0001756_abnormal_urination	0.76762193

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	3.62621979
2	Acute necrotizing encephalopathy (HP:0006965)	3.34457440
3	Progressive macrocephaly (HP:0004481)	3.29118181
4	Polyphagia (HP:0002591)	3.23009486
5	Mitochondrial inheritance (HP:0001427)	3.09826470
6	Abnormal mitochondria in muscle tissue (HP:0008316)	2.99153211
7	Increased CSF lactate (HP:0002490)	2.85832373
8	Hepatic necrosis (HP:0002605)	2.85463533
9	Pancreatic cysts (HP:0001737)	2.79611531
10	Hepatocellular necrosis (HP:0001404)	2.72436460
11	Hypothermia (HP:0002045)	2.69890485
12	Autoimmune thrombocytopenia (HP:0001973)	2.69040823
13	Acute encephalopathy (HP:0006846)	2.67907657
14	Febrile seizures (HP:0002373)	2.63896568
15	Methylmalonic acidemia (HP:0002912)	2.55815158
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.55693345
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.55693345
18	Pancreatic fibrosis (HP:0100732)	2.45666117
19	Medial flaring of the eyebrow (HP:0010747)	2.43476784
20	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.41671224
21	Increased hepatocellular lipid droplets (HP:0006565)	2.40530620
22	True hermaphroditism (HP:0010459)	2.39515647
23	Renal cortical cysts (HP:0000803)	2.37941450
24	Ketoacidosis (HP:0001993)	2.30894152
25	Abnormal respiratory motile cilium physiology (HP:0012261)	2.30346264
26	Abnormality of midbrain morphology (HP:0002418)	2.29968658
27	Molar tooth sign on MRI (HP:0002419)	2.29968658
28	Hyperventilation (HP:0002883)	2.29764095
29	Abnormal ciliary motility (HP:0012262)	2.29234541
30	Stomatitis (HP:0010280)	2.29068331
31	Recurrent abscess formation (HP:0002722)	2.24726581
32	Abnormality of vitamin B metabolism (HP:0004340)	2.23809136
33	Increased IgM level (HP:0003496)	2.18468086
34	Lipid accumulation in hepatocytes (HP:0006561)	2.17873853
35	Neuroendocrine neoplasm (HP:0100634)	2.16868533
36	Glycosuria (HP:0003076)	2.10771426
37	Abnormality of urine glucose concentration (HP:0011016)	2.10771426
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.10008503
39	Abnormal respiratory epithelium morphology (HP:0012253)	2.10008503
40	Limb dystonia (HP:0002451)	2.09762719
41	Cerebral edema (HP:0002181)	2.09402716
42	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.08918906
43	Rhinitis (HP:0012384)	2.07707681
44	Recurrent bacterial skin infections (HP:0005406)	2.07133196
45	Abnormality of the renal cortex (HP:0011035)	2.06533888
46	Abolished electroretinogram (ERG) (HP:0000550)	2.04251420
47	Gait imbalance (HP:0002141)	2.03733246
48	Atonic seizures (HP:0010819)	2.00681756
49	Respiratory failure (HP:0002878)	1.99664242
50	Recurrent gram-negative bacterial infections (HP:0005420)	1.99539608
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98302369
52	Absent/shortened dynein arms (HP:0200106)	1.98302369
53	Methylmalonic aciduria (HP:0012120)	1.97486281
54	Autoimmune hemolytic anemia (HP:0001890)	1.95236094
55	Exertional dyspnea (HP:0002875)	1.94065127
56	Retrobulbar optic neuritis (HP:0100654)	1.93312904
57	Optic neuritis (HP:0100653)	1.93312904
58	Renal Fanconi syndrome (HP:0001994)	1.92953553
59	Hypoglycemic coma (HP:0001325)	1.92820882
60	Mutism (HP:0002300)	1.92261895
61	Nephronophthisis (HP:0000090)	1.91430419
62	Amyotrophic lateral sclerosis (HP:0007354)	1.90001505
63	Abnormal eating behavior (HP:0100738)	1.89911108
64	Congenital primary aphakia (HP:0007707)	1.89550317
65	Ketosis (HP:0001946)	1.89334273
66	Nephrogenic diabetes insipidus (HP:0009806)	1.89114651
67	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.88430281
68	Dialeptic seizures (HP:0011146)	1.88420894
69	Pheochromocytoma (HP:0002666)	1.87795437
70	Lactic acidosis (HP:0003128)	1.84014079
71	Epileptic encephalopathy (HP:0200134)	1.83282786
72	Bronchiectasis (HP:0002110)	1.82443201
73	Congenital, generalized hypertrichosis (HP:0004540)	1.82031489
74	Congenital stationary night blindness (HP:0007642)	1.79625973
75	Stomach cancer (HP:0012126)	1.78582425
76	Hemiparesis (HP:0001269)	1.75326246
77	Optic disc pallor (HP:0000543)	1.73460147
78	CNS demyelination (HP:0007305)	1.72555687
79	Petechiae (HP:0000967)	1.71949028
80	Focal seizures (HP:0007359)	1.71666233
81	Abnormality of renal resorption (HP:0011038)	1.71028312
82	Focal motor seizures (HP:0011153)	1.70873074
83	Generalized aminoaciduria (HP:0002909)	1.70121633
84	Absent speech (HP:0001344)	1.70020849
85	Abnormal hair whorl (HP:0010721)	1.67919709
86	Abnormality of alanine metabolism (HP:0010916)	1.66912693
87	Hyperalaninemia (HP:0003348)	1.66912693
88	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.66912693
89	Intestinal atresia (HP:0011100)	1.65877808
90	Lethargy (HP:0001254)	1.65301184
91	Leukodystrophy (HP:0002415)	1.63487474
92	Abnormality of lateral ventricle (HP:0030047)	1.62438236
93	Muscular hypotonia of the trunk (HP:0008936)	1.62143386
94	Increased serum lactate (HP:0002151)	1.62132323
95	Tinnitus (HP:0000360)	1.62093128
96	Large for gestational age (HP:0001520)	1.61105363
97	Abnormality of vitamin metabolism (HP:0100508)	1.59378685
98	Epidermoid cyst (HP:0200040)	1.57552229
99	X-linked dominant inheritance (HP:0001423)	1.57519907
100	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.56232420

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	3.81719747
2	MAP3K12	3.78241571
3	FRK	3.72911706
4	TRIM28	2.69595799
5	BMPR2	2.48571171
6	ERBB3	2.30575184
7	PINK1	2.26549814
8	STK16	2.16123220
9	BCR	1.89169127
10	MAPK13	1.86896113
11	CASK	1.83892693
12	ADRBK2	1.80125509
13	TLK1	1.69947564
14	TAOK3	1.69190100
15	ACVR1B	1.65785969
16	RIPK4	1.64373304
17	MAP4K2	1.63094243
18	CAMKK2	1.55017261
19	MAP2K7	1.54589317
20	TXK	1.54181143
21	MAP3K4	1.47563794
22	MARK1	1.47255469
23	MAP2K4	1.43380761
24	OXSR1	1.41260688
25	BLK	1.31344290
26	GRK1	1.23050340
27	EIF2AK3	1.20468186
28	WNK3	1.20216190
29	CSNK1G2	1.18647169
30	NTRK3	1.17147431
31	TAOK1	1.16721403
32	GRK7	1.11287802
33	TEC	1.10122232
34	CDK19	1.09348114
35	MAP3K2	1.08861544
36	MAP3K5	1.06826188
37	STK24	1.05959087
38	PLK2	1.04913661
39	MAP3K14	1.03241769
40	CSNK1G3	1.01907486
41	DAPK2	0.91143870
42	EPHA3	0.90126664
43	SYK	0.89152936
44	MAP3K6	0.88576956
45	PIK3CA	0.86835462
46	SIK3	0.85043157
47	CSNK1A1L	0.82940306
48	CSNK1G1	0.82933368
49	PAK3	0.82548086
50	BMPR1B	0.82210408
51	LYN	0.78255115
52	PLK4	0.77564223
53	EIF2AK1	0.75960822
54	NME1	0.75239573
55	YES1	0.74593875
56	IKBKB	0.72555766
57	MINK1	0.70188851
58	PRKCE	0.67472604
59	PHKG2	0.65205727
60	PHKG1	0.65205727
61	NEK1	0.62413541
62	ZAK	0.61535922
63	MAP2K6	0.61278332
64	CSF1R	0.60862644
65	MAP3K11	0.60844952
66	PRKG1	0.60438396
67	BTK	0.60411818
68	PRKCG	0.59766050
69	PKN1	0.57756803
70	ADRBK1	0.57230385
71	CLK1	0.56854127
72	TYK2	0.55576298
73	PIK3CG	0.55195036
74	DYRK2	0.53883183
75	JAK2	0.53401300
76	IKBKE	0.52333030
77	CAMK2A	0.51814594
78	HCK	0.51234406
79	TNIK	0.49641306
80	PRKCQ	0.48215161
81	NUAK1	0.47630058
82	GRK6	0.47116068
83	MAPKAPK5	0.46223975
84	ABL1	0.45300860
85	TRPM7	0.43390785
86	PRKACA	0.43307154
87	VRK1	0.43196948
88	MATK	0.43134936
89	FGFR2	0.42718730
90	IRAK1	0.39892079
91	EGFR	0.39288580
92	CSK	0.38422619
93	MARK3	0.38365946
94	PRKACG	0.35756641
95	RPS6KA5	0.35483902
96	FER	0.35156661
97	CCNB1	0.34256763
98	LCK	0.33733580
99	PRKCB	0.33379651
100	STK3	0.32606930

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.62023329
2	Type I diabetes mellitus_Homo sapiens_hsa04940	2.96636019
3	Asthma_Homo sapiens_hsa05310	2.92808340
4	Parkinsons disease_Homo sapiens_hsa05012	2.88288480
5	Protein export_Homo sapiens_hsa03060	2.86060214
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.54233106
7	Allograft rejection_Homo sapiens_hsa05330	2.47869597
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46651715
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.40113479
10	Collecting duct acid secretion_Homo sapiens_hsa04966	2.32955811
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.21250189
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18057704
13	Rheumatoid arthritis_Homo sapiens_hsa05323	2.07320712
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96538449
15	Alzheimers disease_Homo sapiens_hsa05010	1.93763144
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88585349
17	Huntingtons disease_Homo sapiens_hsa05016	1.71504618
18	Caffeine metabolism_Homo sapiens_hsa00232	1.61622079
19	Butanoate metabolism_Homo sapiens_hsa00650	1.59684617
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.55337207
21	Nicotine addiction_Homo sapiens_hsa05033	1.52674223
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.40898090
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40634451
24	Legionellosis_Homo sapiens_hsa05134	1.34416065
25	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.32210127
26	Homologous recombination_Homo sapiens_hsa03440	1.25724680
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.25210812
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.22514642
29	Sulfur metabolism_Homo sapiens_hsa00920	1.16548927
30	Leishmaniasis_Homo sapiens_hsa05140	1.15668606
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15610637
32	Phototransduction_Homo sapiens_hsa04744	1.11080296
33	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.05463584
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05061044
35	Fatty acid elongation_Homo sapiens_hsa00062	1.03849591
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00060310
37	Phagosome_Homo sapiens_hsa04145	0.99171889
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98405912
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97897955
40	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96486357
41	Tuberculosis_Homo sapiens_hsa05152	0.96165930
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96053349
43	GABAergic synapse_Homo sapiens_hsa04727	0.94160839
44	Regulation of autophagy_Homo sapiens_hsa04140	0.93927646
45	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.91727674
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.91449956
47	Propanoate metabolism_Homo sapiens_hsa00640	0.91108271
48	Peroxisome_Homo sapiens_hsa04146	0.87709457
49	African trypanosomiasis_Homo sapiens_hsa05143	0.87013614
50	Proteasome_Homo sapiens_hsa03050	0.86609196
51	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86436559
52	Folate biosynthesis_Homo sapiens_hsa00790	0.85142155
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.84769536
54	Serotonergic synapse_Homo sapiens_hsa04726	0.84534167
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81604437
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81412379
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79235605
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78738983
59	Olfactory transduction_Homo sapiens_hsa04740	0.73658426
60	Type II diabetes mellitus_Homo sapiens_hsa04930	0.73473822
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73402432
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73247311
63	Morphine addiction_Homo sapiens_hsa05032	0.73234316
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72277878
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.71816340
66	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.70551858
67	Circadian entrainment_Homo sapiens_hsa04713	0.68604523
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66865315
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61659513
70	Viral myocarditis_Homo sapiens_hsa05416	0.61121515
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.59999598
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.57159712
73	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.55504391
74	Taste transduction_Homo sapiens_hsa04742	0.54836274
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53718094
76	Retinol metabolism_Homo sapiens_hsa00830	0.53637268
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.50460892
78	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50331590
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49785957
80	Vibrio cholerae infection_Homo sapiens_hsa05110	0.49655407
81	Salmonella infection_Homo sapiens_hsa05132	0.45624270
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.44801871
83	RNA polymerase_Homo sapiens_hsa03020	0.44745761
84	Insulin secretion_Homo sapiens_hsa04911	0.44621125
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.44406091
86	Mismatch repair_Homo sapiens_hsa03430	0.44131803
87	Influenza A_Homo sapiens_hsa05164	0.43447030
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42460452
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42165325
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.41684445
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40308849
92	Metabolic pathways_Homo sapiens_hsa01100	0.39600655
93	Pertussis_Homo sapiens_hsa05133	0.37150863
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36175453
95	Basal transcription factors_Homo sapiens_hsa03022	0.34948004
96	RNA degradation_Homo sapiens_hsa03018	0.32261381
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31832421
98	Measles_Homo sapiens_hsa05162	0.31301161
99	Herpes simplex infection_Homo sapiens_hsa05168	0.30245340
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30221749

C4ORF33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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