ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.30376516
2	behavioral response to nicotine (GO:0035095)	5.74601515
3	L-fucose metabolic process (GO:0042354)	4.73079143
4	L-fucose catabolic process (GO:0042355)	4.73079143
5	fucose catabolic process (GO:0019317)	4.73079143
6	indole-containing compound catabolic process (GO:0042436)	4.28407836
7	indolalkylamine catabolic process (GO:0046218)	4.28407836
8	tryptophan catabolic process (GO:0006569)	4.28407836
9	kynurenine metabolic process (GO:0070189)	4.24103935
10	indolalkylamine metabolic process (GO:0006586)	4.16498928
11	sulfation (GO:0051923)	3.99166253
12	cellular ketone body metabolic process (GO:0046950)	3.83939082
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.75754610
14	tryptophan metabolic process (GO:0006568)	3.66376594
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47890510
16	indole-containing compound metabolic process (GO:0042430)	3.43871249
17	ketone body metabolic process (GO:1902224)	3.40518208
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.40100754
19	detection of light stimulus involved in visual perception (GO:0050908)	3.40100754
20	primary amino compound metabolic process (GO:1901160)	3.31241956
21	serotonin metabolic process (GO:0042428)	3.28593132
22	neural tube formation (GO:0001841)	3.28089762
23	neuronal action potential (GO:0019228)	3.27008785
24	nephron epithelium morphogenesis (GO:0072088)	3.21197043
25	nephron tubule morphogenesis (GO:0072078)	3.21197043
26	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.18818157
27	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.18818157
28	regulation of translation, ncRNA-mediated (GO:0045974)	3.18818157
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.17043189
30	reflex (GO:0060004)	3.08582194
31	gamma-aminobutyric acid transport (GO:0015812)	3.03769357
32	regulation of hippo signaling (GO:0035330)	3.03549648
33	spinal cord motor neuron differentiation (GO:0021522)	3.01340948
34	signal peptide processing (GO:0006465)	2.98024962
35	cornea development in camera-type eye (GO:0061303)	2.95981826
36	epithelial cilium movement (GO:0003351)	2.92911751
37	kidney morphogenesis (GO:0060993)	2.92549750
38	regulation of action potential (GO:0098900)	2.89859439
39	protein K11-linked deubiquitination (GO:0035871)	2.89439078
40	nonmotile primary cilium assembly (GO:0035058)	2.86395669
41	regulation of gene silencing by RNA (GO:0060966)	2.82278726
42	regulation of posttranscriptional gene silencing (GO:0060147)	2.82278726
43	regulation of gene silencing by miRNA (GO:0060964)	2.82278726
44	oxidative demethylation (GO:0070989)	2.81667923
45	cilium morphogenesis (GO:0060271)	2.78492084
46	regulation of mesoderm development (GO:2000380)	2.76138849
47	negative regulation of mast cell activation (GO:0033004)	2.75963280
48	DNA deamination (GO:0045006)	2.74444303
49	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.74227029
50	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.74227029
51	cilium organization (GO:0044782)	2.72500336
52	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.72418029
53	synaptic transmission, cholinergic (GO:0007271)	2.71389334
54	axoneme assembly (GO:0035082)	2.69592777
55	amine catabolic process (GO:0009310)	2.67121882
56	cellular biogenic amine catabolic process (GO:0042402)	2.67121882
57	NAD biosynthetic process (GO:0009435)	2.66628136
58	negative regulation of telomere maintenance (GO:0032205)	2.65251620
59	protein localization to cilium (GO:0061512)	2.65164139
60	behavioral response to ethanol (GO:0048149)	2.64750449
61	cilium movement (GO:0003341)	2.63441521
62	cilium assembly (GO:0042384)	2.62504010
63	membrane depolarization during action potential (GO:0086010)	2.62448703
64	photoreceptor cell maintenance (GO:0045494)	2.62409036
65	cellular response to ATP (GO:0071318)	2.61255810
66	piRNA metabolic process (GO:0034587)	2.59569171
67	proline transport (GO:0015824)	2.59202006
68	peristalsis (GO:0030432)	2.58099790
69	somite development (GO:0061053)	2.57485054
70	reciprocal DNA recombination (GO:0035825)	2.56182944
71	reciprocal meiotic recombination (GO:0007131)	2.56182944
72	thyroid hormone metabolic process (GO:0042403)	2.56011272
73	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.55889243
74	fucosylation (GO:0036065)	2.55093528
75	renal tubule morphogenesis (GO:0061333)	2.54798969
76	rhodopsin mediated signaling pathway (GO:0016056)	2.54248793
77	water-soluble vitamin biosynthetic process (GO:0042364)	2.53953714
78	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53002516
79	NADH dehydrogenase complex assembly (GO:0010257)	2.53002516
80	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53002516
81	startle response (GO:0001964)	2.52822152
82	benzene-containing compound metabolic process (GO:0042537)	2.52688436
83	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.52325748
84	cAMP catabolic process (GO:0006198)	2.52203829
85	interkinetic nuclear migration (GO:0022027)	2.52052505
86	multicellular organism reproduction (GO:0032504)	2.50498033
87	protein polyglutamylation (GO:0018095)	2.49526109
88	replication fork processing (GO:0031297)	2.49033336
89	photoreceptor cell development (GO:0042461)	2.48926240
90	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.47755843
91	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47531806
92	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.46742488
93	rRNA catabolic process (GO:0016075)	2.46548229
94	respiratory chain complex IV assembly (GO:0008535)	2.45920764
95	establishment of protein localization to Golgi (GO:0072600)	2.43352816
96	retinal cone cell development (GO:0046549)	2.43127741
97	negative regulation of systemic arterial blood pressure (GO:0003085)	2.42613510
98	positive regulation of action potential (GO:0045760)	2.42154932
99	regulation of hexokinase activity (GO:1903299)	2.41775655
100	regulation of glucokinase activity (GO:0033131)	2.41775655

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.84551562
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.39746312
3	VDR_22108803_ChIP-Seq_LS180_Human	3.25751127
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.12742294
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.89323945
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74846619
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61964063
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34010848
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32093015
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.23386159
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13621084
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12569557
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11466569
14	EWS_26573619_Chip-Seq_HEK293_Human	2.10555255
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.08921907
16	FUS_26573619_Chip-Seq_HEK293_Human	2.08817891
17	P300_19829295_ChIP-Seq_ESCs_Human	2.03595278
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.93962222
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81095255
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79533275
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.75673463
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75186135
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72471973
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68585940
25	STAT3_23295773_ChIP-Seq_U87_Human	1.68163434
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65271722
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63897143
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.63671958
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62364570
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61102084
31	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59336169
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56023455
33	AR_25329375_ChIP-Seq_VCAP_Human	1.55860904
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55561762
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55561762
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.51827412
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49397439
38	TCF4_23295773_ChIP-Seq_U87_Human	1.48728112
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48552384
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45625183
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45291881
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.43354947
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42959302
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42067122
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41001529
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.40334169
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40334169
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36994284
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35640985
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29708603
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.28981813
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.28743869
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28081030
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25976616
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.25811304
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25391028
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25391028
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25304757
59	TP53_16413492_ChIP-PET_HCT116_Human	1.24862146
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23942640
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23049246
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22402137
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21843971
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21796007
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20956765
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19103828
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17944974
68	DROSHA_22980978_ChIP-Seq_HELA_Human	1.16297632
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15164468
70	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14746802
71	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14746802
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14313688
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14133759
74	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.14008560
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13939599
76	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13228659
77	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.12803598
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10561663
79	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10230344
80	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10202998
81	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10047153
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09684745
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09481549
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09322622
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09160951
86	MYC_18940864_ChIP-ChIP_HL60_Human	1.08028982
87	AHR_22903824_ChIP-Seq_MCF-7_Human	1.08025267
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07876255
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07752263
90	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.07240527
91	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.06044111
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05926748
93	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04441728
94	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03280243
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02856716
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01238702
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01217961
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01084843
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00635737
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99829234

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.43450008
2	MP0003195_calcinosis	3.18119054
3	MP0002102_abnormal_ear_morphology	2.46875334
4	MP0005551_abnormal_eye_electrophysiolog	2.43177757
5	MP0003136_yellow_coat_color	2.42392778
6	MP0003646_muscle_fatigue	2.29031634
7	MP0001968_abnormal_touch/_nociception	2.26690564
8	MP0008877_abnormal_DNA_methylation	2.25482662
9	MP0004043_abnormal_pH_regulation	2.22138127
10	MP0004142_abnormal_muscle_tone	2.18412236
11	MP0009046_muscle_twitch	2.13837057
12	MP0002837_dystrophic_cardiac_calcinosis	2.04675416
13	MP0009745_abnormal_behavioral_response	2.03012814
14	MP0002653_abnormal_ependyma_morphology	1.91937422
15	MP0006292_abnormal_olfactory_placode	1.88867003
16	MP0008872_abnormal_physiological_respon	1.87493531
17	MP0002638_abnormal_pupillary_reflex	1.84037443
18	MP0006072_abnormal_retinal_apoptosis	1.83659052
19	MP0002876_abnormal_thyroid_physiology	1.79746940
20	MP0000427_abnormal_hair_cycle	1.79267252
21	MP0004133_heterotaxia	1.78462216
22	MP0002736_abnormal_nociception_after	1.77866919
23	MP0002938_white_spotting	1.75998857
24	MP0005646_abnormal_pituitary_gland	1.73642109
25	MP0004145_abnormal_muscle_electrophysio	1.70744273
26	MP0001501_abnormal_sleep_pattern	1.69909932
27	MP0000383_abnormal_hair_follicle	1.67887254
28	MP0005253_abnormal_eye_physiology	1.65898477
29	MP0004885_abnormal_endolymph	1.65150515
30	MP0001485_abnormal_pinna_reflex	1.64485311
31	MP0001986_abnormal_taste_sensitivity	1.63822509
32	MP0000631_abnormal_neuroendocrine_gland	1.62558960
33	MP0002735_abnormal_chemical_nociception	1.61326013
34	MP0002928_abnormal_bile_duct	1.61266459
35	MP0002272_abnormal_nervous_system	1.60424246
36	MP0005645_abnormal_hypothalamus_physiol	1.56945891
37	MP0002064_seizures	1.54013066
38	MP0006276_abnormal_autonomic_nervous	1.53003267
39	MP0008875_abnormal_xenobiotic_pharmacok	1.49668981
40	MP0008961_abnormal_basal_metabolism	1.45530955
41	MP0001486_abnormal_startle_reflex	1.41015260
42	MP0005174_abnormal_tail_pigmentation	1.40967864
43	MP0002572_abnormal_emotion/affect_behav	1.40964666
44	MP0003787_abnormal_imprinting	1.37502945
45	MP0005084_abnormal_gallbladder_morpholo	1.36666504
46	MP0002733_abnormal_thermal_nociception	1.33050802
47	MP0000372_irregular_coat_pigmentation	1.30784014
48	MP0001970_abnormal_pain_threshold	1.25976810
49	MP0010386_abnormal_urinary_bladder	1.23869716
50	MP0004147_increased_porphyrin_level	1.23168253
51	MP0002067_abnormal_sensory_capabilities	1.21672981
52	MP0004742_abnormal_vestibular_system	1.19572452
53	MP0004924_abnormal_behavior	1.18366382
54	MP0005386_behavior/neurological_phenoty	1.18366382
55	MP0002557_abnormal_social/conspecific_i	1.17834289
56	MP0003011_delayed_dark_adaptation	1.17412564
57	MP0003890_abnormal_embryonic-extraembry	1.11896781
58	MP0002138_abnormal_hepatobiliary_system	1.10433308
59	MP0005195_abnormal_posterior_eye	1.10100169
60	MP0002160_abnormal_reproductive_system	1.09396649
61	MP0003635_abnormal_synaptic_transmissio	1.07013867
62	MP0002063_abnormal_learning/memory/cond	1.06649578
63	MP0004215_abnormal_myocardial_fiber	1.06177602
64	MP0003880_abnormal_central_pattern	1.03714728
65	MP0005389_reproductive_system_phenotype	1.03569428
66	MP0001984_abnormal_olfaction	1.00713148
67	MP0004130_abnormal_muscle_cell	1.00349271
68	MP0000230_abnormal_systemic_arterial	0.99247788
69	MP0002277_abnormal_respiratory_mucosa	0.99061476
70	MP0005423_abnormal_somatic_nervous	0.98719522
71	MP0001905_abnormal_dopamine_level	0.93896160
72	MP0003283_abnormal_digestive_organ	0.93512219
73	MP0000026_abnormal_inner_ear	0.92301872
74	MP0002734_abnormal_mechanical_nocicepti	0.91881891
75	MP0002234_abnormal_pharynx_morphology	0.90161770
76	MP0003119_abnormal_digestive_system	0.90053085
77	MP0003252_abnormal_bile_duct	0.88876433
78	MP0000778_abnormal_nervous_system	0.87999571
79	MP0008995_early_reproductive_senescence	0.87974871
80	MP0005085_abnormal_gallbladder_physiolo	0.87691400
81	MP0002163_abnormal_gland_morphology	0.87367925
82	MP0003937_abnormal_limbs/digits/tail_de	0.87251490
83	MP0002752_abnormal_somatic_nervous	0.87208566
84	MP0005410_abnormal_fertilization	0.87114684
85	MP0001324_abnormal_eye_pigmentation	0.84116224
86	MP0002095_abnormal_skin_pigmentation	0.83926124
87	MP0005448_abnormal_energy_balance	0.83856931
88	MP0003137_abnormal_impulse_conducting	0.81911396
89	MP0002693_abnormal_pancreas_physiology	0.80918605
90	MP0003698_abnormal_male_reproductive	0.80866437
91	MP0001440_abnormal_grooming_behavior	0.80696477
92	MP0000538_abnormal_urinary_bladder	0.79106358
93	MP0008775_abnormal_heart_ventricle	0.78191852
94	MP0002184_abnormal_innervation	0.77480870
95	MP0002229_neurodegeneration	0.76286515
96	MP0001919_abnormal_reproductive_system	0.76276868
97	MP0005171_absent_coat_pigmentation	0.75994816
98	MP0001502_abnormal_circadian_rhythm	0.75591065
99	MP0001963_abnormal_hearing_physiology	0.74744398
100	MP0005167_abnormal_blood-brain_barrier	0.74246579

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.86178238
2	True hermaphroditism (HP:0010459)	4.40792864
3	Pancreatic fibrosis (HP:0100732)	4.30049820
4	Abnormality of midbrain morphology (HP:0002418)	4.14046245
5	Molar tooth sign on MRI (HP:0002419)	4.14046245
6	Congenital stationary night blindness (HP:0007642)	3.78150832
7	Nephronophthisis (HP:0000090)	3.75105526
8	Genetic anticipation (HP:0003743)	3.43087218
9	Hyperventilation (HP:0002883)	3.32562261
10	Abnormality of the renal medulla (HP:0100957)	3.27398978
11	Abnormality of the renal cortex (HP:0011035)	3.25694908
12	Cystic liver disease (HP:0006706)	3.16142355
13	Attenuation of retinal blood vessels (HP:0007843)	3.14872595
14	Progressive cerebellar ataxia (HP:0002073)	3.10076307
15	Abnormality of alanine metabolism (HP:0010916)	3.02796503
16	Hyperalaninemia (HP:0003348)	3.02796503
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.02796503
18	Type II lissencephaly (HP:0007260)	3.00377442
19	Chronic hepatic failure (HP:0100626)	3.00087372
20	Abolished electroretinogram (ERG) (HP:0000550)	2.92316641
21	Medial flaring of the eyebrow (HP:0010747)	2.90044606
22	Tubular atrophy (HP:0000092)	2.85301548
23	Inability to walk (HP:0002540)	2.75852725
24	Furrowed tongue (HP:0000221)	2.75620323
25	Protruding tongue (HP:0010808)	2.73893797
26	Clumsiness (HP:0002312)	2.71422990
27	Large for gestational age (HP:0001520)	2.70780638
28	Pendular nystagmus (HP:0012043)	2.68941268
29	Congenital, generalized hypertrichosis (HP:0004540)	2.66401261
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.65598672
31	Gaze-evoked nystagmus (HP:0000640)	2.64680188
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.55341959
33	Absent/shortened dynein arms (HP:0200106)	2.55341959
34	Sclerocornea (HP:0000647)	2.52607025
35	Cerebellar dysplasia (HP:0007033)	2.49103918
36	Increased corneal curvature (HP:0100692)	2.46312787
37	Keratoconus (HP:0000563)	2.46312787
38	Patellar aplasia (HP:0006443)	2.42809700
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.42359307
40	Polydipsia (HP:0001959)	2.42131944
41	Abnormal drinking behavior (HP:0030082)	2.42131944
42	Decreased circulating renin level (HP:0003351)	2.41650983
43	Concave nail (HP:0001598)	2.37083054
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.37022941
45	Febrile seizures (HP:0002373)	2.35967384
46	Progressive inability to walk (HP:0002505)	2.34347184
47	Aplasia/Hypoplasia of the patella (HP:0006498)	2.33573926
48	Congenital hepatic fibrosis (HP:0002612)	2.31526769
49	Male pseudohermaphroditism (HP:0000037)	2.30312931
50	Gait imbalance (HP:0002141)	2.27717114
51	Birth length less than 3rd percentile (HP:0003561)	2.24807984
52	Anencephaly (HP:0002323)	2.22792720
53	Fair hair (HP:0002286)	2.22395716
54	Decreased central vision (HP:0007663)	2.17886445
55	Congenital primary aphakia (HP:0007707)	2.17781018
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.16610779
57	Lissencephaly (HP:0001339)	2.16527353
58	Bony spicule pigmentary retinopathy (HP:0007737)	2.15357779
59	Broad-based gait (HP:0002136)	2.11714629
60	Renal cortical cysts (HP:0000803)	2.10111972
61	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.08608639
62	Abnormal respiratory epithelium morphology (HP:0012253)	2.06112113
63	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06112113
64	Abnormality of the renal collecting system (HP:0004742)	2.05500414
65	Congenital sensorineural hearing impairment (HP:0008527)	2.04057254
66	Abnormality of the pons (HP:0007361)	2.01287103
67	Abnormal ciliary motility (HP:0012262)	2.00879734
68	Duplicated collecting system (HP:0000081)	2.00369778
69	Nephrogenic diabetes insipidus (HP:0009806)	1.99357065
70	Genital tract atresia (HP:0001827)	1.97677337
71	Hypoplasia of the pons (HP:0012110)	1.96597969
72	Hemiparesis (HP:0001269)	1.94898494
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93335277
74	Severe muscular hypotonia (HP:0006829)	1.92728230
75	Vaginal atresia (HP:0000148)	1.92341671
76	Stomach cancer (HP:0012126)	1.90791586
77	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90541399
78	Chorioretinal atrophy (HP:0000533)	1.89094434
79	Optic nerve hypoplasia (HP:0000609)	1.86866748
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.86835788
81	Hypothermia (HP:0002045)	1.86760095
82	Polyuria (HP:0000103)	1.85524487
83	Postaxial foot polydactyly (HP:0001830)	1.85324877
84	Abnormal biliary tract physiology (HP:0012439)	1.81392508
85	Bile duct proliferation (HP:0001408)	1.81392508
86	Widely spaced teeth (HP:0000687)	1.76581031
87	Generalized hypopigmentation of hair (HP:0011358)	1.76205462
88	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75068607
89	Focal motor seizures (HP:0011153)	1.74514649
90	Dialeptic seizures (HP:0011146)	1.73241777
91	Hypoplastic ischia (HP:0003175)	1.72970444
92	Oligodactyly (hands) (HP:0001180)	1.70962742
93	Partial agenesis of the corpus callosum (HP:0001338)	1.69762447
94	Small hand (HP:0200055)	1.69324209
95	Poor coordination (HP:0002370)	1.68789808
96	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.68414706
97	Preaxial hand polydactyly (HP:0001177)	1.66208349
98	Tachypnea (HP:0002789)	1.65556868
99	Dandy-Walker malformation (HP:0001305)	1.64700090
100	Bilateral microphthalmos (HP:0007633)	1.63344499

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.00268974
2	BMPR1B	3.74798397
3	ADRBK2	3.51607941
4	ACVR1B	3.48136794
5	TAOK3	2.62242848
6	ZAK	2.45992510
7	GRK1	2.42269713
8	WNK3	2.37727437
9	WNK4	2.29098742
10	INSRR	2.25518073
11	PNCK	2.03077120
12	TLK1	1.97351558
13	MAP4K2	1.93626048
14	MAPK13	1.91018240
15	PINK1	1.73623340
16	TGFBR1	1.71249905
17	MAP3K4	1.62803355
18	CASK	1.61420444
19	NUAK1	1.60486989
20	MAPK15	1.47804069
21	MKNK2	1.46566706
22	AKT3	1.45702944
23	ADRBK1	1.43928563
24	OXSR1	1.39825170
25	TNIK	1.34230061
26	DAPK2	1.33152855
27	TXK	1.27024340
28	MARK1	1.11942445
29	STK39	1.06566229
30	NTRK3	1.04386517
31	PIK3CA	1.00172207
32	BRSK2	0.92510302
33	PAK3	0.92252004
34	PRKCG	0.91094227
35	WEE1	0.90866906
36	STK38L	0.89802645
37	PTK2B	0.88673052
38	PRKCE	0.85097920
39	FGFR2	0.84544706
40	CAMKK2	0.80332082
41	MAPKAPK5	0.78692238
42	TIE1	0.77103244
43	DYRK2	0.75681926
44	MAP2K7	0.74752952
45	OBSCN	0.73653696
46	VRK1	0.73023519
47	PHKG2	0.72338599
48	PHKG1	0.72338599
49	TRPM7	0.72015641
50	MAPKAPK3	0.69372518
51	MKNK1	0.68998324
52	PIK3CG	0.67569940
53	MUSK	0.67436145
54	MAP2K6	0.66185215
55	PKN1	0.64911697
56	TEC	0.64110218
57	NLK	0.63218122
58	STK3	0.60707663
59	CHUK	0.56163173
60	RPS6KA5	0.55467570
61	KIT	0.54937110
62	IKBKB	0.54467166
63	CAMK2A	0.53055699
64	SGK2	0.52714341
65	NTRK2	0.50168260
66	NEK2	0.49148845
67	PLK2	0.48764336
68	IRAK1	0.47825539
69	STK11	0.46590781
70	MAP2K1	0.46339311
71	TRIM28	0.46234086
72	MAP2K4	0.45890932
73	TAF1	0.44916529
74	CAMK1	0.43506793
75	PRKAA2	0.43472207
76	RPS6KA6	0.43256945
77	GRK7	0.43244688
78	PRKCQ	0.43051381
79	PRKACA	0.42976515
80	PLK4	0.42884903
81	FLT3	0.39268660
82	PRKAA1	0.39156241
83	WNK1	0.36756601
84	CHEK2	0.35640838
85	SGK494	0.33995053
86	SGK223	0.33995053
87	CAMK1D	0.33828551
88	PRKG1	0.33792308
89	CSNK1G1	0.32868124
90	MELK	0.32336392
91	CAMK1G	0.30180483
92	CSNK1G2	0.29884228
93	MAP3K7	0.29143319
94	CSNK1A1	0.29122074
95	ITK	0.28956209
96	PRKCA	0.28930694
97	PRKCH	0.28571362
98	SIK2	0.28541656
99	CSNK1D	0.26914353
100	CDK19	0.26830366

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	2.97364592
2	Phototransduction_Homo sapiens_hsa04744	2.82257012
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.70871873
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.66974310
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.58221813
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.55782413
7	Butanoate metabolism_Homo sapiens_hsa00650	2.50962673
8	Nicotine addiction_Homo sapiens_hsa05033	2.40616815
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.20611578
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.17523604
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.08568157
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.05427165
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.02455650
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98895864
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82132815
16	Homologous recombination_Homo sapiens_hsa03440	1.79728545
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.78841175
18	Taste transduction_Homo sapiens_hsa04742	1.77224928
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59335365
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.58501226
21	Morphine addiction_Homo sapiens_hsa05032	1.56060731
22	ABC transporters_Homo sapiens_hsa02010	1.54579453
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.54542693
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47253905
25	Olfactory transduction_Homo sapiens_hsa04740	1.46557467
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42365896
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38067409
28	Basal transcription factors_Homo sapiens_hsa03022	1.36714130
29	Circadian entrainment_Homo sapiens_hsa04713	1.34119849
30	Serotonergic synapse_Homo sapiens_hsa04726	1.31822256
31	Caffeine metabolism_Homo sapiens_hsa00232	1.28996777
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28297337
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.25341299
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21139089
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.20158190
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.19816307
37	Insulin secretion_Homo sapiens_hsa04911	1.16873559
38	GABAergic synapse_Homo sapiens_hsa04727	1.15258480
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.11881580
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07059367
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06501200
42	Parkinsons disease_Homo sapiens_hsa05012	1.04933279
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04630394
44	Histidine metabolism_Homo sapiens_hsa00340	1.02748864
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02741178
46	Calcium signaling pathway_Homo sapiens_hsa04020	1.01607682
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01002573
48	Protein export_Homo sapiens_hsa03060	0.96599973
49	Asthma_Homo sapiens_hsa05310	0.96515525
50	RNA polymerase_Homo sapiens_hsa03020	0.95152111
51	Salivary secretion_Homo sapiens_hsa04970	0.93750467
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.92163892
53	Propanoate metabolism_Homo sapiens_hsa00640	0.92118631
54	Retinol metabolism_Homo sapiens_hsa00830	0.90729673
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88348419
56	Peroxisome_Homo sapiens_hsa04146	0.84003559
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.83880287
58	Huntingtons disease_Homo sapiens_hsa05016	0.80099958
59	RNA degradation_Homo sapiens_hsa03018	0.77773918
60	One carbon pool by folate_Homo sapiens_hsa00670	0.77767236
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.77739035
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75056293
63	Alzheimers disease_Homo sapiens_hsa05010	0.71947650
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69519552
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69028786
66	Regulation of autophagy_Homo sapiens_hsa04140	0.68222818
67	Circadian rhythm_Homo sapiens_hsa04710	0.67923903
68	Cocaine addiction_Homo sapiens_hsa05030	0.64600535
69	Long-term depression_Homo sapiens_hsa04730	0.63643613
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63549469
71	Cholinergic synapse_Homo sapiens_hsa04725	0.63264818
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.61665791
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59610000
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.59152196
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58096635
76	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.57852491
77	Mineral absorption_Homo sapiens_hsa04978	0.56794983
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.53516946
79	Gastric acid secretion_Homo sapiens_hsa04971	0.52341537
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.51750285
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50524735
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49334851
83	Amphetamine addiction_Homo sapiens_hsa05031	0.49257952
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49219042
85	Type I diabetes mellitus_Homo sapiens_hsa04940	0.47871367
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.47469256
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41171098
88	Renin secretion_Homo sapiens_hsa04924	0.40714494
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.39663636
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36727208
91	Sulfur metabolism_Homo sapiens_hsa00920	0.36658861
92	Metabolic pathways_Homo sapiens_hsa01100	0.36581898
93	Purine metabolism_Homo sapiens_hsa00230	0.36195407
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35763395
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.34744314
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32766737
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32360797
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.32173037
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.32095107
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30600428

C4ORF36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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